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https://www.readbyqxmd.com/read/29757061/exercise-induced-laryngeal-obstruction-in-athletes-contributory-factors-and-treatment-implications
#1
Liv-Jorunn Kolnes, Trine Stensrud
Otherwise healthy adolescent athletes presenting with respiratory symptoms consistent with exercise-induced laryngeal obstruction (EILO) are frequently encountered in clinical practice. The symptoms are often incorrectly considered to result from exercise-induced asthma, and may be wrongly treated as such. Given the potential implications for health and performance if EILO is left untreated, a more comprehensive understanding of contributory mechanisms is essential in order to create appropriate treatment procedures...
May 14, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29730423/exercise-ventilatory-irregularity-can-be-quantified-by-approximate-entropy-to-detect-breathing-pattern-disorder
#2
Taranpal Bansal, Gulam S Haji, Harry B Rossiter, Mike I Polkey, James H Hull
BACKGROUND: Breathing pattern disorder (BPD) is a prevalent cause of exertional dyspnea and yet there is currently no reliable objective measure for its diagnosis. We propose that statistical analysis of ventilatory irregularity, quantified by approximate entropy (ApEn), could be used to detect BPD when applied to cardiopulmonary exercise test (CPET) data. We hypothesized that ApEn of ventilatory variables (tidal volume (VT ), breathing frequency (Bf ), minute ventilation (VE )) would be greater, i...
May 3, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29680425/prevalence-and-characteristics-of-sleep-disordered-breathing-in-familial-dysautonomia
#3
Kanwaljit Singh, Jose-Alberto Palma, Horacio Kaufmann, Nataliya Tkachenko, Lucy Norcliffe-Kaufmann, Christy Spalink, Mikhail Kazachkov, Sanjeev V Kothare
OBJECTIVE: Familial dysautonomia (FD) is an autosomal recessive disorder characterized by impaired development of sensory and afferent autonomic nerves. Untreated sleep-disordered breathing (SDB) has been reported to increase the risk of sudden unexpected death in FD. We aimed to describe the prevalence and characteristics of SDB in FD. PATIENTS/METHODS: Seventy-five patients with FD (20 adults and 55 children) underwent in-lab polysomnography, including peripheral capillary oxygen saturation (SpO2 ) and end-tidal capnography (EtCO2 ) measurements...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29597138/rapid-eye-movement-sleep-behavior-disorder-or-epileptic-seizure-during-sleep-a-video-analysis-of-motor-events
#4
Vi-Huong Nguyen-Michel, Ovidio Solano, Smaranda Leu-Semenescu, Aurélie Pierre-Justin, Ana Gales, Vincent Navarro, Michel Baulac, Claude Adam, Sophie Dupont, Isabelle Arnulf
PURPOSE: To compare the motor semiology of sleep behavior disorder (RBD) during rapid eye movement (REM) with epileptic seizures in non-REM and REM sleep. METHODS: We analyzed the types and frequency of motor events from videos of patients with RBD (n = 15, mean age 64.8 years, 179 motor episodes) and patients with epilepsy (n = 15, mean age 34.4 years, 87 sleep-related epileptic seizures including 34 during REM sleep). RESULTS: Patients with sleep-related epileptic seizures more often woke up abruptly (28% vs...
March 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29590325/real-time-monitoring-using-a-breathalyzer-based-ehealth-system-can-identify-lapse-relapse-patterns-in-alcohol-use-disorder-patients
#5
Markku D Hämäläinen, Andreas Zetterström, Maria Winkvist, Marcus Söderquist, Elin Karlberg, Patrik Öhagen, Karl Andersson, Fred Nyberg
Aim: We introduce a new remote real-time breathalyzer-based method for monitoring and early identification of lapse/relapse patterns for alcohol use disorder (AUD) patients using a composite measure of sobriety, the Addiction Monitoring Index (AMI). Methods: We constructed AMI from (a) obtained test results and (b) the pattern of ignored tests using data from the first 30 patients starting in the treatment arms of two on-going clinical trials. The patients performed 2-4 scheduled breath alcohol content (BrAC)-tests per day presented as blood alcohol content (BAC) data...
March 24, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29549772/can-subjective-sleep-problems-detect-latent-sleep-disorders-among-commercial-drivers
#6
Michael K Lemke, Yorghos Apostolopoulos, Adam Hege, Sharon Newnam, Sevil Sönmez
INTRODUCTION: Long-haul truck drivers experience poor sleep health and heightened accident rates, and undiagnosed sleep disorders contribute to these negative outcomes. Subjective sleep disorder screening tools may aid in detecting drivers' sleep disorders. This study sought to evaluate the value of subjective screening methods for detecting latent sleep disorders and identifying truck drivers at-risk for poor sleep health and safety-relevant performance. MATERIALS AND METHODS: Using cross-sectional data from 260 long-haul truck drivers, we: 1) used factor analysis to identify possible latent sleep disorders; 2) explored the construct validity of extracted sleep disorder factors by determining their associations with established sleep disorder risk factors and symptoms; and 3) explored the predictive validity of resulting sleep disorder factors by determining their associations with sleep health and safety-relevant performance...
March 14, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29515212/positive-airway-pressure-therapy-for-sleep-disordered-breathing-confers-short-term-benefits-to-patients-with-spinal-cord-injury-despite-widely-ranging-patterns-of-use
#7
Jeanette P Brown, Kristy A Bauman, Armando Kurili, Gianna M Rodriguez, Anthony E Chiodo, Robert G Sitrin, Helena M Schotland
STUDY DESIGN: Prospective, cohort study. OBJECTIVES: To evaluate the effectiveness of bi-level positive airway pressure (PAP) therapy and the patterns of use for sleep-disordered breathing (SDB) in individuals with spinal cord injury (SCI). SETTING: Academic tertiary care center, USA. METHODS: Overall, 91 adults with C1-T6 SCI for ≥3 months were recruited and 74 remained in the study to be evaluated for SDB and follow-up...
March 7, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29511898/relationship-between-abdominal-symptoms-and-fructose-ingestion-in-children-with-chronic-abdominal-pain
#8
Veronika Hammer, Katharina Hammer, Nima Memaran, Wolf-Dietrich Huber, Karin Hammer, Johann Hammer
BACKGROUND: Limited valid data are available regarding the association of fructose-induced symptoms, fructose malabsorption, and clinical symptoms. AIM: To develop a questionnaire for valid symptom assessment before and during a carbohydrate breath test and to correlate symptoms with fructose breath test results in children/adolescents with functional abdominal pain. METHODS: A Likert-type questionnaire assessing symptoms considered relevant for hydrogen breath test in children was developed and underwent initial validation...
May 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29487248/association-of-pediatric-obstructive-sleep-apnea-with-poor-academic-performance-a-school-based-study-from-india
#9
Abhishek Goyal, Abhijit P Pakhare, Girish C Bhatt, Bharat Choudhary, Rajesh Patil
Background: Pediatric obstructive sleep apnea (OSA) is a highly prevalent but often neglected disorder. There is paucity of reports on the prevalence of pediatric OSA from India. This study was done to estimate the prevalence of OSA in school children aged 5-10 years and its association with academic performance. Methodology: This school-based cross-sectional epidemiological study was conducted from July 2015 to November 2015. A questionnaire seeking information on sociodemographic variables, school performance, sleeping pattern, and a validated 22-item pediatrics sleep-related breathing disorder (SRBD) scale was distributed to 1820 pupils in three primary schools...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29484287/long-term-non-invasive-ventilation-in-infants-a-systematic-review-and-meta-analysis
#10
Prabhjot K Bedi, Maria Luisa Castro-Codesal, Robin Featherstone, Mohammed M AlBalawi, Bashar Alkhaledi, Anita L Kozyrskyj, Carlos Flores-Mir, Joanna E MacLean
Background: The use of long-term non-invasive ventilation (NIV) to treat sleep and breathing disorders in children has increased substantially in the last decade; however, less data exist about its use in infants. Given that infants have distinct sleep and breathing patterns when compared to older children, the outcomes of infants on long-term NIV may differ as well. The aim of this study is to systematically review the use and outcomes of long-term NIV in infants. Methods: Ovid Medline, Ovid Embase, CINAHL (via EbscoHOST), PubMed, and Wiley Cochrane Library were systematically searched from January 1990 to July 2017...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29474534/cdkl5-protein-substitution-therapy-rescues-neurological-phenotypes-of-a-mouse-model-of-cdkl5-disorder
#11
Stefania Trazzi, Marianna De Franceschi, Claudia Fuchs, Stefano Bastianini, Rocchina Viggiano, Leonardo Lupori, Raffaele Mazziotti, Giorgio Medici, Viviana Lo Martire, Elisa Ren, Roberto Rimondini, Giovanna Zoccoli, Renata Bartesaghi, Tommaso Pizzorusso, Elisabetta Ciani
Cyclin-dependent kinase like-5 (CDKL5) disorder is a rare neurodevelopmental disease caused by mutations in the CDKL5 gene. The consequent misexpression of the CDKL5 protein in the nervous system leads to a severe phenotype characterized by intellectual disability, motor impairment, visual deficits and early-onset epilepsy. No therapy is available for CDKL5 disorder. It has been reported that a protein transduction domain (TAT) is able to deliver macromolecules into cells and even into the brain when fused to a given protein...
May 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29468173/effect-of-desipramine-on-patients-with-breathing-disorders-in-rett-syndrome
#12
Josette Mancini, Jean-Christophe Dubus, Elisabeth Jouve, Jean-Christophe Roux, Patricia Franco, Emmanuelle Lagrue, Pierre Castelnau, Claude Cances, Yves Chaix, Christelle Rougeot-Jung, Catherine Cornu, Vincent Desportes, Louis Vallée, Nadia Bahi-Buisson, Romain Truillet, Laurence Attolini, Laurent Villard, Olivier Blin, Joëlle Micallef
Objective: Rett Syndrome (RTT) is a severe neurodevelopmental condition with breathing disorders, affecting around one in 10,000 female births. Desipramine, a noradrenaline reuptake inhibitor, reduced the number of apneas in Mecp2-deficient mice, a model of RTT. We planned a phase 2 trial to test its efficacy and its safety on breathing patterns in 36 girls with RTT. Methods: The trial was a 6-month, multicenter, randomized, double-blind, placebo-controlled study registered with ClinicalTrials...
February 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29467674/an-improved-dynamic-model-for-the-respiratory-response-to-exercise
#13
Leidy Y Serna, Miguel A Mañanas, Alher M Hernández, Roberto A Rabinovich
Respiratory system modeling has been extensively studied in steady-state conditions to simulate sleep disorders, to predict its behavior under ventilatory diseases or stimuli and to simulate its interaction with mechanical ventilation. Nevertheless, the studies focused on the instantaneous response are limited, which restricts its application in clinical practice. The aim of this study is double: firstly, to analyze both dynamic and static responses of two known respiratory models under exercise stimuli by using an incremental exercise stimulus sequence (to analyze the model responses when step inputs are applied) and experimental data (to assess prediction capability of each model)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29410749/surgical-treatment-of-a-pattern-i-obstructive-sleep-apnea-syndrome-individual-clinical-case-report
#14
Christiane Cavalcante Feitoza, Matheus Corrêa da-Silva, Yasmim Lima Nascimento, Elaine Sobral Leite, Corintho Viana Pereira, Lucas Gomes Patrocínio
Obstructive Sleep Apnea Syndrome (OSA) is a multifactorial disease that highly alters a persons quality of life. It is characterized by the repeated interruption of breathing during sleep, due to an obstruction or the collapse of the upper airways. Since it is a multifactorial etiological disorder, it requires a thorough diagnosis and treatment with an interdisciplinary team, which comprises several professionals such as a surgical dentist, phonoaudiologist, otorhinolaryngologist, sleep doctor, neurologist and physiotherapist...
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29386443/-electromyography-analysis-of-rapid-eye-movement-sleep-behavior-disorder
#15
Natsuko Nakano, Fumiya Kinoshita, Hiroki Takada, Meiho Nakayama
Polysomnography (PSG), which records physiological phenomena including brain waves, breathing status, and muscle tonus, is useful for the diagnosis of sleep disorders as a gold standard. However, measurement and analysis are complex for several specific sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD). Usually, brain waves during REM sleep indicate an awakening pattern under relaxed conditions of skeletal and antigravity muscles. However, these muscles are activated during REM sleep when patients suffer from RBD...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29338120/the-association-between-different-features-of-sleep-disordered-breathing-and-blood-pressure-a-cross-sectional-study
#16
Shayan Khoshkish, Mathias Hohl, Benedikt Linz, Michael Arzt, Felix Mahfoud, Mathias Baumert, Jakob Schöpe, Michael Böhm, Dominik Linz
Sleep disordered breathing (SDB) is highly prevalent in patients with high blood pressure (BP). Severity of SDB can be evaluated by the number of apneas and hypopneas per hour (AHI) or by measures of hypoxia. The objective of this study was to assess the association between different measures of SDB and BP. In 134 consecutive patients, polygraphy was performed to determine the AHI. Pulse oximetry was used to determine hypoxemic burden (time below 90% oxygen saturation [T90] and hypoxia load [HL], representing the integrated area above the curve of desaturation)...
March 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29318372/severe-obstructive-sleep-disorders-in-prader-willi-syndrome-patients-in-southern-italy
#17
Angelo Canora, Adriana Franzese, Enza Mozzillo, Valentina Fattorusso, Marialuisa Bocchino, Alessandro Sanduzzi
Sleep-related disordered breathing (SDB) is very common in paediatric patients affected by Prader-Willi Syndrome (PWS). However, data addressing SBD patterns and their management are lacking. The aim of the present study was to analyse SDB features in 14 PWS patients (age range, 8 months-17 years). Polygraphic registration (PG) during a 12-h nocturnal sleep was performed in all patients. Obstructive and central apnoea indices and oxygen saturation (SpO2 ) were recorded along with demographic and clinical data...
January 9, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273025/exhaled-breath-condensate-metabolome-clusters-for-endotype-discovery-in-asthma
#18
Anirban Sinha, Koundinya Desiraju, Kunal Aggarwal, Rintu Kutum, Siddhartha Roy, Rakesh Lodha, S K Kabra, Balaram Ghosh, Tavpritesh Sethi, Anurag Agrawal
BACKGROUND: Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath condensate (EBC) is a relatively unexplored matrix which reflects the signatures of respiratory epithelium, but is difficult to normalize for dilution. METHODS: Here we explored whether internally normalized global NMR spectrum patterns, combined with machine learning, could be useful for diagnostics or endotype discovery...
December 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29208477/impact-of-opioid-therapy-on-sleep-and-respiratory-patterns-in-adults-with-advanced-cancer-receiving-palliative-care
#19
Phillip Good, Ross Pinkerton, Simon Bowler, Justin Craig, Janet Hardy
CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life, but the impact of opioid-related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnea, and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnography...
March 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29179024/effects-of-brief-mindfulness-and-loving-kindness-meditation-inductions-on-emotional-and-behavioral-responses-to-social-rejection-among-individuals-with-high-borderline-personality-traits
#20
Shian-Ling Keng, Hui Han Tan
Borderline personality disorder (BPD) is characterized by an enduring pattern of instability across affective, behavioral, cognitive, and interpersonal domains. Individuals with BPD are known to be particularly vulnerable to experiences of social rejection, but little work has examined strategies that may moderate their reactivity to social rejection. Using a laboratory experimental approach, this study investigated the effects of brief mindfulness and loving-kindness meditation (LKM) inductions on emotional and behavioral responses to social rejection in a sample of adults with high BPD traits...
January 2018: Behaviour Research and Therapy
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