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https://www.readbyqxmd.com/read/27860499/premixed-insulin-analogue-compared-with-basal-plus-regimen-for-inpatient-glycemic-control
#1
Abraham Edgar Gracia-Ramos, María Del Pilar Cruz-Domínguez, Eduardo Osiris Madrigal-Santillán, José Antonio Morales-González, Eduardo Madrigal-Bujaidar, José Leopoldo Aguilar-Faisal
BACKGROUND: No previous studies have investigated the use of a premixed insulin analogue in a hospital setting. OBJECTIVE: To compare the efficacy and safety of treatment with premixed insulin analogue (insulin lispro mix 75/25, LM75/25) with the basal-plus regimen with insulin glargine in hospitalized patients with type 2 diabetes (T2D). MATERIALS AND METHODS: A randomized clinical trial in hospitalized patients with T2D and glucose >140 mg/dL on admission was performed...
November 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27852883/wound-closure-in-smoking-peripheral-arterial-disease-patients-with-treatment-refractory-ulcerations-a-12-month-follow-up-case-series
#2
Jonathan Smedley, Georgina M Michael, Yeabsera G Tamire
Despite ongoing smoking cessation efforts and optimized perfusion, failed wound closure in the presence of peripheral arterial disease (PAD) and diabetes are common. A clinical effectiveness review was conducted in actively smoking diabetic patients diagnosed with PAD, treated with serial applications of a viable intact cryopreserved human placental membrane (vCPM) (Grafix, Osiris Therapeutics Inc, Columbia, MD) for recalcitrant lower extremity ulcerations (n = 6). More than half of the patients were not candidates for revascularization...
November 15, 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27790789/simeprevir-plus-sofosbuvir-for-eight-or-12-weeks-in-treatment-na%C3%A3-ve-and-treatment-experienced-hepatitis-c-virus-genotype-4-patients-with-or-without-cirrhosis
#3
M El Raziky, M Gamil, M K Ashour, E A Sameea, W Doss, Y Hamada, G Van Dooren, R DeMasi, S Keim, I Lonjon-Domanec, R Hammad, M S Hashim, M Hassany, I Waked
The OSIRIS study investigated efficacy and safety of simeprevir plus sofosbuvir for eight or 12 weeks in hepatitis C virus (HCV) genotype 4-infected patients with METAVIR F0-F4 fibrosis. Sixty-three patients (33 treatment-naïve and 30 peg-interferon/ribavirin (Peg-IFN/RBV)-experienced) enrolled in a partly randomized, open-label, multicentre, phase IIa study. Patients with F0-F3 fibrosis were randomized (1:1) into two groups (A1 and A2), stratified according to treatment experience and METAVIR score, to receive either eight weeks (Group A1, n=20) or 12 weeks (Group A2, n=20) of treatment...
October 27, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27766221/preliminary-safety-assessment-of-new-azinesulfonamide-analogs-of-aripiprazole-using-prokaryotic-models
#4
Beata Powroźnik, Karolina Słoczyńska, Krzysztof Marciniec, Paweł Zajdel, Elżbieta Pękala
Purpose: Determination of the mutagenic potential of new biologically active compounds is of great concern for preliminary toxicity testing and drug development. Methods: The mutagenic and antimutagenic effects of some quinoline- and isoquinolinesulfonamide analogs of aripiprazole (1-8), which display potent antidepressant, anxiolytic, and antipsychotic properties, were evaluated using the Vibrio harveyi assay and OSIRIS Property Explorer software. Additionally, the Ames test was used as the reference. Results: In silico prediction showed that compounds 5 (N-(3-(4-(2,3- dichlorophenyl)piperazin-1-yl)propyl)quinoline-7-sulfonamide) and 6 (N-(4-(4-(2,3- Dichlorophenyl)piperazin-1-yl)butyl)quinoline-7-sulfonamide) trigger a mutagenic structural alert...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27681807/viable-intact-cryopreserved-human-placental-membrane-for-a-non-surgical-approach-to-closure-in-complex-wounds
#5
K Suzuki, G Michael, Y Tamire
OBJECTIVE: Advances in wound treatment have yielded successful approaches to complex wound closure through plastic surgery or other staged surgical methods. However, not all patients or wounds are candidates for such increasingly rigorous levels of interventions. The exploration of non-surgical treatment options that promote anatomical and functional tissue replacement on an outpatient basis without donor site morbidity is necessary to maximise opportunities for patient mobility and rehabilitation...
October 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27667093/validation-of-osteoporosis-risk-assessment-tools-in-middle-aged-thai-women
#6
S Indhavivadhana, M Rattanachaiyanont, S Angsuwathana, K Techatraisak, P Tanmahasamut, P Leerasiri
OBJECTIVES: To validate osteoporosis risk assessment tools in middle-aged Thai women. METHODS: A total of 1038 women who had bone mineral density (BMD) measurements using dual-energy X-ray absorptiometry were reviewed. Clinical data were used to validate the diagnostic test performance of various osteoporosis risk assessment tools, including ABONE, FRAX(®), ORAI, OSIRIS, SCORE, SOFSURF, and OSTA. The following parameters were evaluated: sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy; those with 95% confidence interval (CI) of the receiver operator characteristics area under the curve (ROC-AUC) > 0...
September 24, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27589856/an-obstetric-sphincter-injury-risk-identification-system-osiris-is-this-a-clinically-useful-tool
#7
Sara S Webb, Karla Hemming, Madhi Y Khalfaoui, Tine Brink Henriksen, Sara Kindberg, Stine Stensgaard, Christine Kettle, Khaled M K Ismail
INTRODUCTION AND HYPOTHESIS: To establish the contribution of maternal, fetal and intrapartum factors to the risk of incidence of obstetric anal sphincter injuries (OASIS) and assess the feasibility of an OASIS risk prediction model based on variables available to clinicians prior to birth. METHODS: This was a population-based, retrospective cohort study using single-site data from the birth database of Aarhus University Hospital, Denmark. The participants were all women who had a singleton vaginal birth during the period 1989 to 2006...
September 2, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27556322/profile-of-heart-donors-from-the-human-valve-bank-of-the-santa-casa-de-miseric%C3%A3-rdia-de-curitiba
#8
Renata Maria Ferreira, Marise Teresinha Brenner Affonso da Costa, Osiris Canciglieri Junior, Ângelo Márcio Oliveira Sant'Anna
INTRODUCTION: Human heart valves are used as replacement valves and have satisfactory functional results compared with conventional prostheses. OBJECTIVE: Characterize the profile of effective heart donors from the human valve bank of the santa casa de misericórdia de curitiba and analyze the association between the profile variables. METHODS: It consists of a retrospective and quantitative study of electronic medical records from heart donors for heart valves...
April 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27494993/computational-strategies-to-explore-antimalarial-thiazine-alkaloid-lead-compounds-based-on-an-australian-marine-sponge-plakortis-lita
#9
Lilly Aswathy, Radhakrishnan S Jisha, Vijay H Masand, Jayant M Gajbhiye, Indira G Shibi
In this work, an attempt was made to propose new leads based on the natural scaffold Thiaplakortone-A active against malaria. The 2D QSAR studies suggested that three descriptors correlate with the anti-malarial activity with an R(2) value of 0.814. Robustness, reliability and predictive power of the model were tested by internal validation, external validation, Y-scrambling and Applicability domain analysis. HQSAR studies were carried out as an additional tool to find the sub-structural fingerprints. The CoMFA and CoMSIA models gave Q(2) values of 0...
August 5, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27428963/ligand-and-structure-based-approaches-for-the-identification-of-peptide-deformylase-inhibitors-as-antibacterial-drugs
#10
Jian Gao, Li Liang, Yasheng Zhu, Shengzhi Qiu, Tao Wang, Ling Zhang
Peptide deformylase (PDF) is a metalloprotease catalyzing the removal of a formyl group from newly synthesized proteins, which makes it an important antibacterial drug target. Given the importance of PDF inhibitors like actinonin in antibacterial drug discovery, several reported potent PDF inhibitors were used to develop pharmacophore models using the Galahad module of Sybyl 7.1 software. Generated pharmacophore models were composed of two donor atom centers, four acceptor atom centers and two hydrophobic groups...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27413345/synthesis-characterization-and-in-silico-biological-activity-of-some-2-n-n-dimethyl-guanidinyl-4-6-diaryl-pyrimidines
#11
Rajasekhar Komarla Kumarachari, Sivakumar Peta, Abdrrahman Shemsu Surur, Yenus Tadesse Mekonnen
INTRODUCTION: As pyrimidine is a basic nucleus in DNA and RNA, it has been found to be associated with diverse biological activities. Pyrimidine derivatives were reported to possess anticonvulsant, antimicrobial, anti-inflammatory, antitumor, and antihistaminic. Recently, our team reported the anti-inflammatory and antimicrobial evaluation of some pyrimidines. OBJECTIVE: To synthesize, predict and evaluate biological activity of some 2-(N,N-dimethyl guanidinyl)-4,6-diaryl pyrimidines...
July 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27304881/characterization-of-five-novel-brevibacillus-bacteriophages-and-genomic-comparison-of-brevibacillus-phages
#12
Jordan A Berg, Bryan D Merrill, Justin T Crockett, Kyle P Esplin, Marlee R Evans, Karli E Heaton, Jared A Hilton, Jonathan R Hyde, Morgan S McBride, Jordan T Schouten, Austin R Simister, Trever L Thurgood, Andrew T Ward, Donald P Breakwell, Sandra Hope, Julianne H Grose
Brevibacillus laterosporus is a spore-forming bacterium that causes a secondary infection in beehives following European Foulbrood disease. To better understand the contributions of Brevibacillus bacteriophages to the evolution of their hosts, five novel phages (Jenst, Osiris, Powder, SecTim467, and Sundance) were isolated and characterized. When compared with the five Brevibacillus phages currently in NCBI, these phages were assigned to clusters based on whole genome and proteome synteny. Powder and Osiris, both myoviruses, were assigned to the previously described Jimmer-like cluster...
2016: PloS One
https://www.readbyqxmd.com/read/27247412/heme-dynamics-and-trafficking-factors-revealed-by-genetically-encoded-fluorescent-heme-sensors
#13
David A Hanna, Raven M Harvey, Osiris Martinez-Guzman, Xiaojing Yuan, Bindu Chandrasekharan, Gheevarghese Raju, F Wayne Outten, Iqbal Hamza, Amit R Reddi
Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and heme signaling are ultimately reliant on the ability to mobilize labile heme (LH). However, the properties of LH pools, including concentration, oxidation state, distribution, speciation, and dynamics, are poorly understood. Herein, we elucidate the nature and dynamics of LH using genetically encoded ratiometric fluorescent heme sensors in the unicellular eukaryote Saccharomyces cerevisiae We find that the subcellular distribution of LH is heterogeneous; the cytosol maintains LH at ∼20-40 nM, whereas the mitochondria and nucleus maintain it at concentrations below 2...
July 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27207023/risk-management-model-of-winter-navigation-operations
#14
Osiris A Valdez Banda, Floris Goerlandt, Vladimir Kuzmin, Pentti Kujala, Jakub Montewka
The wintertime maritime traffic operations in the Gulf of Finland are managed through the Finnish-Swedish Winter Navigation System. This establishes the requirements and limitations for the vessels navigating when ice covers this area. During winter navigation in the Gulf of Finland, the largest risk stems from accidental ship collisions which may also trigger oil spills. In this article, a model for managing the risk of winter navigation operations is presented. The model analyses the probability of oil spills derived from collisions involving oil tanker vessels and other vessel types...
July 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27196447/comparisons-of-different-screening-tools-for-identifying-fracture-osteoporosis-risk-among-community-dwelling-older-people
#15
Sy-Jou Chen, Yi-Ju Chen, Chui-Hsuan Cheng, Hei-Fen Hwang, Chih-Yi Chen, Mau-Roung Lin
A prospective study was conducted to compare criterion, predictive, and construct validities of 9 fracture/osteoporosis assessment tools, including calcaneal quantitative ultrasonography (QUS), Age Bulk One or Never Estrogens (ABONE), body weight criterion (BWC), Fracture Risk Assessment Tool (FRAX), Garvan fracture risk calculator (GARVAN), Osteoporosis Risk Assessment Instrument (ORAI), Osteoporosis Index of Risk (OSIRIS), Osteoporosis Self-Assessment Tool for Asians (OSTA), and Simple Calculated Osteoporosis Risk Estimation (SCORE), among older men and women in Taiwan...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27188857/inflammatory-cytokine-levels-disease-activity-and-function-of-patients-with-rheumatoid-arthritis-treated-with-combined-conventional-disease-modifying-antirheumatic-drugs-or-biologics
#16
Manathip Osiri, Jongkonnee Wongpiyabovorn, Youwanuch Sattayasomboon, Niramol Thammacharoenrach
The objective of this study was to compare the effects of treatment by combined conventional disease-modifying antirheumatic drugs (cDMARDs) or biologics on cytokines, disease activity, and function in rheumatoid arthritis (RA). Sera from a cohort of 81 patients with long-standing RA treated with combined cDMARDs or biologics were measured for 12 cytokines. Comparisons of serum cytokine concentrations with treatment types (combination 2, 3 cDMARDs or biologics), serologic status (positivity for RF and anti-cyclic citrullinated peptide antibody (anti-CCP Ab)), DAS28-ESR, and function were performed...
July 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27141229/3-d-structural-interactions-and-quantitative-structural-toxicity-studies-of-tyrosine-derivatives-intended-for-safe-potent-inflammation-treatment
#17
Ayarivan Puratchikody, Dharmaraj Sriram, Appavoo Umamaheswari, Navabshan Irfan
BACKGROUND: Drugs that inhibit cyclooxygenase-2 (COX-2) while sparing cyclooxygenase-1 (COX-1) represent a new attractive therapeutic development and offer new perspective for further use of COX-2 inhibitors. Intention of this work is to develop safer, selective COX-2 inhibitors that do not produce harmful effects. RESULTS: A series of 55 tyrosine derivatives were designed for evaluation as selective COX-2 inhibitors and investigated by in silico for their anti-inflammatory activities using C-Docker...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27140186/synthesis-anticlotting-and-antiplatelet-effects-of-1-2-3-triazoles-derivatives
#18
Laura de Andrade Moura, Ana Carolina Marqui de Almeida, Andreza Vieira da Silva, Vivian Rodrigues de Souza, Vitor Francisco Ferreira, Michel Vieira Menezes, Carlos Roland Kaiser, Sabrina Baptista Ferreira, André Lopes Fuly
BACKGROUND: Cardiovascular diseases, such as thrombosis and stroke, represent the major cause of disability and death worldwide; and dysfunctions in platelet aggregation and blood coagulation processes are involved. The regular antithrombotic drugs have unsatisfactory results and may produce side effects. Therefore, alternative therapies have been extensively investigated. OBJECTIVE: The anticoagulant and antiplatelet aggregation potential of a series of six synthetic 1,2,3-triazole derivatives were investigated through in vitro models...
May 2, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27134887/virtual-screening-of-phytochemicals-to-novel-target-hat-rtt109-in-pneumocystis-jirovecii-using-bioinformatics-tools
#19
Ramya Sugumar, Abhinand Ponneri Adithavarman, Anusha Dakshinamoorthi, Darling Chellathai David, Padmavathi Kannan Ragunath
INTRODUCTION: Pneumocystis jirovecii is a fungus that causes Pneumocystis pneumonia in HIV and other immunosuppressed patients. Treatment of Pneumocystis pneumonia with the currently available antifungals is challenging and associated with considerable adverse effects. There is a need to develop drugs against novel targets with minimal human toxicities. Histone Acetyl Transferase (HAT) Rtt109 is a potential therapeutic target in Pneumocystis jirovecii species. HAT is linked to transcription and is required to acetylate conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form e-N-acetyl lysine...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27127610/seasonal-phenotype-specific-transcriptional-reprogramming-during-metamorphosis-in-the-european-map-butterfly-araschnia-levana
#20
Andreas Vilcinskas, Heiko Vogel
The European map butterfly (Araschnia levana) is a classic example of seasonal polyphenism because the spring and summer imagoes display two distinct morphological phenotypes. The light regime and temperature during larval and prepupal development determine whether or not the pupae commit to diapause and overwintering and thus whether spring or summer imagoes emerge. We used suppression subtractive hybridization to experimentally screen for genes that are differentially expressed in prepupae committed either to accelerated metamorphosis and egg production or diapause and overwintering...
April 20, 2016: Ecology and Evolution
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