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https://www.readbyqxmd.com/read/29627177/the-evolutionary-saga-of-circumcision-from-a-religious-perspective
#1
REVIEW
Venkatachalam Raveenthiran
Circumcision is the oldest surgical operation known to mankind. It probably originated as a less radical form of genital mutilation inflicted on prisoners of war. Over time it was adopted by the Egyptian priesthood and nobility, perhaps inspired by the mythology of Osiris. In turn, circumcision became part of the Jewish and Muslim religious cultures. In contrast, ancient Greeks valued an intact prepuce, as evident from the nude figures of Renaissance art. In the 19th century, circumcision was touted as a treatment for excessive masturbation, seizures, epilepsy, and paraplegia...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29619883/clinical-outcomes-with-a-diffractive-trifocal-intraocular-lens
#2
Jorge L Alió, Ana B Plaza-Puche, Jorge L Alió Del Barrio, Pedro Amat-Peral, Vicente Ortuño, Pilar Yébana, Olena Al-Shymali, Alfredo Vega-Estrada
PURPOSE: To evaluate clinical and visual outcomes, quality of near vision, and intraocular optical quality of patients bilaterally implanted with a trifocal PanOptix intraocular lens. METHODS: In this prospective consecutive case-series study, 52 eyes of 26 bilateral patients (mean age, 60.2 ± 7.4 years) were implanted with the AcrySof IQ Panoptix intraocular lens. Visual acuity, defocus curve, contrast sensitivity (Pelli-Robson test), near activity visual questionnaire, and internal aberrations with Osiris were evaluated...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29609141/exploring-the-novel-heterocyclic-derivatives-as-lead-molecules-for-design-and-development-of-potent-anticancer-agents
#3
Iqbal Azad, Malik Nasibullah, Tahmeena Khan, Firoj Hassan, Yusuf Akhter
This paper deals with in silico evaluation of newly proposed heterocyclic derivatives in search of potential anticancer activity. Best possible drug candidates have been proposed using a rational approach employing a pipeline of computational techniques namely MetaPrint2D prediction, molinspiration, cheminformatics, Osiris Data warrior, AutoDock and iGEMDOCK. Lazar toxicity prediction, AdmetSAR predictions, and targeted docking studies were also performed. 27 heterocyclic derivatives were selected for bioactivity prediction and drug likeness score on the basis of Lipinski's rule, Viber rule, Ghose filter, leadlikeness and Pan Assay Interference Compounds (PAINS) rule...
March 9, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29554638/a-study-of-particulate-emissions-during-23-major-industrial-fires-implications-for-human-health
#4
Simon D Griffiths, Philip Chappell, Jane A Entwistle, Frank J Kelly, Michael E Deary
Public exposure to significantly elevated levels of particulate matter (PM) as a result of major fires at industrial sites is a worldwide problem. Our paper describes how the United Kingdom developed its Air Quality in Major Incidents (AQinMI) service to provide fire emission plume concentration data for use by managers at the time of the incident and to allow an informed public health response. It is one of the first civilian services of its type anywhere in the world. Based on the involvement of several of the authors in the AQinMI service, we describe the service's function, detail the nature of fires covered by the service, and report for the first time on the concentration ranges of PM to which populations may be exposed in major incident fires...
March 16, 2018: Environment International
https://www.readbyqxmd.com/read/29548969/tracheal-expression-of-osiris-gene-family-in-drosophila
#5
Aaron Scholl, Yuyang Yang, Patrick McBride, Kelly Irwin, Lan Jiang
The Drosophila trachea is a premier genetic system to investigate the fundamental mechanisms of tubular organ formation. Development of the trachea consists of the well understood early branch specification and migration processes, and the less clear later branch maturation process including the apical membrane expansion, cytoskeleton rearrangement, luminal matrix clearance, and air-filling. We identified seven members of the Osiris (Osi) gene family with obvious tracheal expression in trachea. In addition, HA-tagged Osi proteins are highly concentrated in vesicle-like structures at and near the apical membrane...
March 13, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29527265/morphological-and-biochemical-effects-of-weekend-alcohol-consumption-in-rats-role-of-concentration-and-gender
#6
José A Morales-González, María de Lourdes Sernas-Morales, Ángel Morales-González, Laura Ligía González-López, Eduardo Osiris Madrigal-Santillán, Nancy Vargas-Mendoza, Tomás Alejandro Fregoso-Aguilar, Liliana Anguiano-Robledo, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Germán Chamorro-Cevallos
AIM: To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats. METHODS: Wistar rats weighing 170-200 g were divided into groups as follows: (1) Control groups; and (2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations: (1) Group of males or females with a consumption of a solution of alcohol at 40%; and (2) group of males or females with a consumption of a solution of alcohol at 5%...
February 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29517554/effectiveness-and-drug-survival-of-anti-tumor-necrosis-factor-%C3%AE-therapies-in-patients-with-spondyloarthritis-analysis-from-the-thai-rheumatic-disease-prior-authorization-registry
#7
Praveena Chiowchanwisawakit, Wanruchada Katchamart, Manathip Osiri, Pongthorn Narongroeknawin, Parawee Chevaisrakul, Tasanee Kitumnuaypong, Boonjing Siripaitoon, Worawit Louthrenoo
OBJECTIVE: This study aimed to evaluate the long-term effectiveness and safety of the first anti-tumor necrosis factor α therapy (TNFi) and to identify the associated factors of drug discontinuation in patients with spondyloarthritis. METHODS: This was a retrospective cohort study. Patients with spondyloarthritis who were prescribed the first TNFi between December 2009 and October 2014 in the Rheumatic Disease Prior Authorization registry were enrolled. Baseline clinical data were retrieved...
March 7, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29491627/identification-of-inhibitors-against-metastasis-protein-survivin-in-silico-discovery-using-virtual-screening-and-molecular-docking-studies
#8
Swechha Mishra, Sangeeta Singh
Background: In experimental therapy of cancer, survivin is considered to be one of the well-established targets. Studies have found that it is overexpression in most of the human tumors, but it is rarely found in normal tissues. It is having varied structural and functional role. It controls cell division and cellular stress response and also regulates metastasis and migration of cancerous cells. It has also been recognized as a biomarker which makes it unconventional drug target. In spite of being one of the centrally active components in metastasis and invasion, their clinical use is minimal...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29468005/assessment-of-trained-hand-hygiene-observers-using-parallel-observations
#9
Humberto Guanche Garcell, Ariadna Villanueva Arias, Isme Borroto Garcés, Alexis Cardoso Gil, Pedro Rivero Companioni, Katiana Figueredo Arias, Osiris I Escobar More, Norgely Rivero Rodríguez, Francisco Gutierrez García
Objectives: To validate hand hygiene (HH) observers following training and determine the concordance between the observers and the Kappa index. Methods: This study was conducted during June 2017. HH observers from 15 hospital units received eight-hours training including a two-hour workshop conducted by the infection control practitioner and hospital epidemiologist. After its completion, parallel observations were conducted by trained nurses from each respective unit for a maximum of 20 minutes per session at any time or day...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467856/smoking-and-female-sex-as-key-risk-factors-associated-with-severe-arthralgia-in-acute-and-chronic-phases-of-chikungunya-virus-infection
#10
Ivan Delgado-Enciso, Brenda Paz-Michel, Valery Melnikov, Jose Guzman-Esquivel, Francisco Espinoza-Gomez, Alejandro D Soriano-Hernandez, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Gabriel Ceja-Espiritu, Bertha A Olmedo-Buenrostro, Hector R Galvan-Salazar, Osiris G Delgado-Enciso, Josuel Delgado-Enciso, Uriel A Lopez-Lemus, Daniel A Montes-Galindo
Arthralgia is a potentially incapacitating condition and a persistent symptom in chronic or acute episodes of Chikungunya fever caused by infection with the Chikungunya virus (CHIKV). To the best of our knowledge, there are no reports on risk factors associated with the intensity of arthralgias in typical acute episodes of the disease. Although a number of studies have reported on risk factors associated with the development of the chronic stage of the disease, smoking habits have not been analyzed. Smoking is an interesting factor to consider since it is the main environmental risk factor for the development of rheumatoid arthritis (RA), a similar disease to CHIKV in many aspects...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29357311/d-amino-acids-in-molecular-evolution-in-space-absolute-asymmetric-photolysis-and-synthesis-of-amino-acids-by-circularly-polarized-light
#11
REVIEW
Haruna Sugahara, Cornelia Meinert, Laurent Nahon, Nykola C Jones, Søren V Hoffmann, Kenji Hamase, Yoshinori Takano, Uwe J Meierhenrich
Living organisms on the Earth almost exclusively use l-amino acids for the molecular architecture of proteins. The biological occurrence of d-amino acids is rare, although their functions in various organisms are being gradually understood. A possible explanation for the origin of biomolecular homochirality is the delivery of enantioenriched molecules via extraterrestrial bodies, such as asteroids and comets on early Earth. For the asymmetric formation of amino acids and their precursor molecules in interstellar environments, the interaction with circularly polarized photons is considered to have played a potential role in causing chiral asymmetry...
January 31, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29322640/conserved-roles-of-osiris-genes-in-insect-development-polymorphism-and-protection
#12
C R Smith, C Morandin, M Noureddine, S Pant
Much of the variation among insects is derived from the different ways that chitin has been moulded to form rigid structures, both internal and external. In this study, we identify a highly conserved expression pattern in an insect-only gene family, the Osiris genes, that is essential for development, but also plays a significant role in phenotypic plasticity and in immunity/toxicity responses. The majority of Osiris genes exist in a highly syntenic cluster, and the cluster itself appears to have arisen very early in the evolution of insects...
April 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29289165/the-oxford-space-environment-goniometer-a-new-experimental-setup-for-making-directional-emissivity-measurements-under-a-simulated-space-environment
#13
T J Warren, N E Bowles, K Donaldson Hanna, I R Thomas
Measurements of the light scattering behaviour of the regoliths of airless bodies via remote sensing techniques in the Solar System, across wavelengths from the visible to the far infrared, are essential in understanding their surface properties. A key parameter is knowledge of the angular behaviour of scattered light, usually represented mathematically by a phase function. The phase function is believed to be dependent on many factors including the following: surface composition, surface roughness across all length scales, and the wavelength of radiation...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29275037/open-surgical-implantation-of-a-viable-intact-cryopreserved-human-placental-membrane-for-the-treatment-of-recalcitrant-plantar-fasciitis-case-report-with-greater-than-2-year-follow-up-duration
#14
Xingbo P Sun, Amy G Wilson, Georgina M Michael
Plantar fasciitis is one of the most common conditions encountered by a podiatric physician. Although most individuals respond well to traditional conservative and surgical remedies, a portion of patients will exhaust all available treatment options and will experience ongoing pain that can ultimately affect their quality of life. There has been an increase in scientific and clinical research surrounding the medical use of human placental membranes (HPMs) and many of these point-of-care allografts are now commercially available...
December 20, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29273194/evaluation-of-clinical-and-radiographic-indices-as-predictors-of-osteoporotic-fractures-a-10-year-longitudinal-study
#15
Grethe B Jonasson, Valter Sundh, Magnus Hakeberg, Margareta Ahlqwist, Lauren Lissner, Dominique Hange
OBJECTIVES: The aim of the study was to evaluate 2 radiographic and 3 clinical indices as predictors of future osteoporotic fractures. STUDY DESIGN: In a prospective, longitudinal study with a 10-year fracture follow-up, the 2 radiographic indices mandibular cortical erosion (normal, mild/moderate erosion, and severe erosion of the inferior cortex) and cortex thickness were assessed using panoramic radiographs of 411 women, age 62 to 78 years. The clinical indices were the fracture assessment tool FRAX, the osteoporosis index of risk (OSIRIS), and the osteoporosis self-assessment tool (OST)...
November 21, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#16
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29225432/molecular-docking-based-screening-of-a-simulated-hif-1-protein-model-for-potential-inhibitors
#17
Mundla Sri Latha, Madhu Sudhana Saddala
Hypoxia inducible factor-1(HIF-1) is a bHLH-family transcription factor that control genes involved in glucolysis, angiogenesis, migration, as well as invasion factors that are important for tumor progression and metastasis. HIF-1, a hetero dimer of HIF-1α and HIF-1β, binds to the hypoxia responsive genes, such as vascular endothelial growth factor (VEGF). It is one the molecular target for angiogenesis. A series of Chalcone - like compounds described that preferentially inhibit HIF-1 dimer, which can interact with amino acids within the active site of the protein...
2017: Bioinformation
https://www.readbyqxmd.com/read/29140470/database-resources-of-the-national-center-for-biotechnology-information
#18
(no author information available yet)
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. The Entrez system provides search and retrieval operations for most of these data from 39 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets...
January 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29133211/beta-lactam-resistance-among-enterobacteriaceae-in-cambodia-the-four-year-itch
#19
REVIEW
Yannick Caron, Rattanak Chheang, Nop Puthea, Meng Soda, Sébastien Boyer, Arnaud Tarantola, Alexandra Kerléguer
Although antibiotics are too often used inappropriately in Cambodia, published data on antimicrobial resistance in this country are scarce. Epidemic dissemination and the transfer of resistance genes to other bacterial species put the population at risk. The aim of this study was to evaluate the frequency and characteristics of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) isolated in consecutive samples tested at Institut Pasteur du Cambodge over a 4-year period (2012-2015)...
January 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29021218/transcriptomic-analysis-of-octanoic-acid-response-in-drosophila-sechellia-using-rna-sequencing
#20
Stephen M Lanno, Sara M Gregory, Serena J Shimshak, Maximilian K Alverson, Kenneth Chiu, Arden L Feil, Morgan G Findley, Taylor E Forman, Julia T Gordon, Josephine Ho, Joanna L Krupp, Ivy Lam, Josh Lane, Samuel C Linde, Ashley E Morse, Serena Rusk, Robie Ryan, Avva Saniee, Ruchi B Sheth, Jennifer J Siranosian, Lalitpatr Sirichantaropart, Sonya R Sternlieb, Christina M Zaccardi, Joseph D Coolon
The dietary specialist fruit fly Drosophila sechellia has evolved to specialize on the toxic fruit of its host plant Morinda citrifolia Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 ( Osi6 ), Osi7 , and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia While genes in this major effect locus are beginning to be revealed, prior work has shown at least five regions of the genome contribute to OA resistance...
December 4, 2017: G3: Genes—Genomes—Genetics
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