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https://www.readbyqxmd.com/read/29021218/transcriptomic-analysis-of-octanoic-acid-response-in-drosophila-sechellia%C3%A2-using-rna-sequencing
#1
Stephen M Lanno, Sara M Gregory, Serena J Shimshak, Maximilian K Alverson, Kenneth Chiu, Arden L Feil, Morgan G Findley, Taylor E Forman, Julia T Gordon, Josephine Ho, Joanna L Krupp, Ivy Lam, Josh Lane, Samuel C Linde, Ashley E Morse, Serena Rusk, Robie Ryan, Avva Saniee, Ruchi B Sheth, Jennifer J Siranosian, Lalitpatr Sirichantaropart, Sonya R Sternlieb, Christina M Zaccardi, Joseph D Coolon
The dietary specialist fruit fly Drosophila sechellia has evolved to specialize on the toxic fruit of its host plant Morinda citrifolia Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 (Osi6), Osi7, and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia While genes in this major effect locus are beginning to be revealed, prior work has shown at least five regions of the genome contribute to OA resistance...
October 12, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28970106/assessment-of-predictivity-of-volatile-organic-compounds-carcinogenicity-and-mutagenicity-by-freeware-in-silico-models
#2
Lília Ribeiro Guerra, Alessandra Mendonça Teles de Souza, Juliana Alves Côrtes, Viviane de Oliveira Freitas Lione, Helena Carla Castro, Gutemberg Gomes Alves
The application of in silico methods is increasing on toxicological risk prediction for human and environmental health. This work aimed to evaluate the performance of three in silico freeware models (OSIRIS v.2.0, LAZAR, and Toxtree) on the prediction of carcinogenicity and mutagenicity of thirty-eight volatile organic compounds (VOC) related to chemical risk assessment for occupational exposure. Theoretical data were compared with assessments available in international databases. Confusion matrices and ROC curves were used to evaluate the sensitivity, specificity, and accuracy of each model...
September 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28966254/genotoxic-evaluation-of-duloxetine-ii-the-effect-on-the-number-of-sister-chromatid-exchanges-the-mitotic-index-and-the-proliferation-kinetics-in-mouse-bone-marrow
#3
Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Osiris Madrigal-Santillán, José A Morales-González, Andrea Torres-Gómez, José Melesio Cristóbal-Luna
Duloxetine is an antidepressant which has showed valuable results, particularly in patients with major depression. This type of drugs is known to require genotoxic studies as part of their preclinical safety evaluation. In the case of duloxetine, however, there have been controversial results. Therefore, we considered it worthwhile to extend studies on the matter in an attempt to reach a conclusion. The present assay was made in mouse bone marrow to evaluate the capacity of the drug to induce sister chromatid exchanges (SCE), as well as to modify the proliferation kinetics and the mitotic index...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28894629/isolation-characterization-and-in-silico-docking-studies-of-synergistic-estrogen-receptor-a-anticancer-polyphenols-from-syzygium-alternifolium-wt-walp
#4
Pulicherla Yugandhar, Konidala Kranthi Kumar, Pabbaraju Neeraja, Nataru Savithramma
AIM: This study aims to isolate, characterize, and in silico evaluate of anticancer polyphenols from different parts of Syzygium alternifolium. MATERIALS AND METHODS: The polyphenols were isolated by standard protocol and characterized using Fourier-transform infrared (FT-IR), High performance liquid chromatography - Photodiode array detector coupled with Electrospray ionization - mass spectrometry (MS/MS). The compounds were elucidated based on retention time and molecular ions (m/z) either by [M+H](+)/[M-H](-) with the comparison of standard phenols as well as ReSpect software tool...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28887014/osiris9a-is-a-major-component-of-silk-fiber-in-lepidopteran-insects
#5
Chun Liu, Wenbo Hu, Tingcai Cheng, Zhangchuan Peng, Kazuei Mita, Qingyou Xia
In a previous high-throughput proteomics study, it was found that the silkworm cocoon contains hundreds of complex proteins, many of which have unknown functions, in addition to fibroins, sericins, and some protease inhibitors. Osiris was one of the proteins with no known function. In this study, we identified the Osiris gene family members and constructed a phylogenetic tree based on the sequences from different species. Our results indicate that the Osiris9 gene subfamily contains six members; it is specifically expressed in lepidopteran insects and has evolved by gene duplication...
September 5, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28776297/physiological-mechanisms-of-a-wetland-plant-echinodorus-osiris-rataj-to-cadmium-detoxification
#6
Peng Zhang, He Huang, Wanru Liu, Chaolan Zhang
Physiological responses of Echinodorus osiris Rataj plant under cadmium (Cd) stress (5 and 15 mg L(-1)) were studied by researching the change of non-enzymatic antioxidants and the exudation of root organic acids. There was a significant increase of ascorbic acid, glutathione, and non-protein thiols in the plant, and the increment was much obvious in roots than that in leaves with increased Cd stress. The accumulation of Cd was associated with mitochondrial structural damages in roots, while the organelle structure, such as chloroplast, in leaves remains intact...
August 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28746736/defensive-repertoire-of-drosophila-larvae-in-response-to-toxic-fungi
#7
Monika Trienens, Ken Kraaijeveld, Bregje Wertheim
Chemical warfare including insecticidal secondary metabolites is a well-known strategy for environmental microbes to monopolize a food source. Insects in turn have evolved behavioural and physiological defences to eradicate or neutralize the harmful microorganisms. We studied the defensive repertoire of insects in this interference competition by combining behavioural and developmental assays with whole-transcriptome time-series analysis. Confrontation with the toxic filamentous fungus Aspergillus nidulans severely reduced the survival of Drosophila melanogaster larvae...
July 26, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28480389/evaluation-of-the-anti-inflammatory-capacity-of-beta-sitosterol-in-rodent-assays
#8
Rogelio Paniagua-Pérez, Gabriela Flores-Mondragón, Celia Reyes-Legorreta, Brígida Herrera-López, Isabel Cervantes-Hernández, Osiris Madrigal-Santillán, José Antonio Morales-González, Isela Álvarez-González, Eduardo Madrigal-Bujaidar
BACKGROUND: Beta-sitosterol (BS) is a compound discovered to be present in numerous plants. A number of interesting biomedical properties have been attributed to BS, including immuno-modulating and anti-inflammatory activities. Therefore, the aim of this report was to evaluate its anti-inflammatory capacity by applying various rodent experimental tests. METHODS: To carry out the objective of the study we applied the methods indicated here. Two of the adopted methods were based on the passive reverse Arthus reaction: the rat paw edema test and the rat pleurisy assay...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28374912/a-computational-approach-to-identify-a-potential-alternative-drug-with-its-positive-impact-toward-pmp22
#9
Ashish Kumar Agrahari, George Priya Doss C
Mutations in the Peripheral Myelin Protein 22 (PMP22) leads to Charcot Marie Tooth type 1A (CMT1A, a subtype of CMT1) disease which is the most common inherited neuropathy of peripheral nervous system. In the present study, we used series of in silico prediction methods to screen and identify the most deleterious non-synonymous SNPs (nsSNPs) in PMP22 gene. Out of 48 nsSNPs, five nsSNPs (L16P, L19P, T23R, W28R, and L147R) associated with PMP22 were predicted to be highly deleterious and destabilizing the protein...
April 4, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28330089/discovery-of-potential-alk-inhibitors-by-virtual-screening-approach
#10
Anish Kumar, V Shanthi, K Ramanathan
Crizotinib is an anticancer drug used for the treatment of non-small cell lung cancer. Evidences available suggest that there is a development of an acquired resistance against crizotinib action due to the emergence of several mutations in the ALK gene. It is therefore necessary to develop potent anti-cancer drugs for the treatment of crizotinib resistance non-small cell lung cancer types. In the present study, a novel class of lead molecule was identified using virtual screening, molecular docking and molecular dynamic approach...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28316240/heme-gazing-illuminating-eukaryotic-heme-trafficking-dynamics-and-signaling-with-fluorescent-heme-sensors
#11
David A Hanna, Osiris Martinez-Guzman, Amit R Reddi
Heme (iron protoporphyrin IX) is an essential protein prosthetic group and signaling molecule required for most life on Earth. All heme-dependent processes require the dynamic and rapid mobilization of heme from sites of synthesis or uptake to hemoproteins present in virtually every subcellular compartment. The cytotoxicity and hydrophobicity of heme necessitate that heme mobilization be carefully controlled to mitigate the deleterious effects of this essential toxin. Indeed, a number of disorders, including certain cancers, cardiovascular diseases, and aging and age-related neurodegenerative diseases, are tied to defects in heme homeostasis...
April 4, 2017: Biochemistry
https://www.readbyqxmd.com/read/28254074/development-of-antibacterial-conjugates-using-sulfamethoxazole-with-monocyclic-terpenes-a-systematic-medicinal-chemistry-based-computational-approach
#12
Shasank S Swain, Sudhir K Paidesetty, Rabindra N Padhy
BACKGROUND AND OBJECTIVE: To develop 6 conjugate agents of the moribund antibiotic sulfamethoxazole (SMZ) joined to 6 individual monoterpenes, followed by protocols of medicinal chemistry as potent antibacterials, against multidrug resistant (MDR) human gruesome pathogenic bacteria. METHODS: Antibacterial activities of the proposed conjugates were ascertained by the 'prediction of activity spectra of substances' (PASS) program. Drug-likeness parameters and toxicity profiles of conjugates were standardized with the Lipinski rule of five, using cheminformatic tools, Molsoft, molinspiration, OSIRIS and ProTox...
March 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28128814/-periocular-foreign-body-two-clinical-cases-with-different-management-short-title-periocular-foreign-body
#13
María Sandra Salazar-Ramos, Juan Carlos Serna-Ojeda, Osiris Olvera-Morales, José Luis Tovilla-Canales
BACKGROUND: In many cases, the presence of periocular foreign bodies continues to be a diagnostic challenge and a dilemma regarding their management in most cases. The key lies in the type of material of the foreign body and its location in the orbit to determine its management. CLINICAL CASES: We present two cases of periocular foreign body; a description of the clinical presentation and their treatment are given in each case. A review and discussion of treatment is also included...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28035709/genetic-basis-of-octanoic-acid-resistance-in-drosophila-sechellia-functional-analysis-of-a-fine-mapped-region
#14
J M Andrade López, S M Lanno, J M Auerbach, E C Moskowitz, L A Sligar, P J Wittkopp, J D Coolon
Drosophila sechellia is a species of fruit fly endemic to the Seychelles islands. Unlike its generalist sister species, D. sechellia has evolved to be a specialist on the host plant Morinda citrifolia. This specialization is interesting because the plant's fruit contains secondary defence compounds, primarily octanoic acid (OA), that are lethal to most other Drosophilids. Although ecological and behavioural adaptations to this toxic fruit are known, the genetic basis for evolutionary changes in OA resistance is not...
February 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28009761/adherence-to-and-acceptance-of-once-daily-tacrolimus-after-kidney-and-liver-transplant-results-from-osiris-a-french-observational-study-erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Transplantation
https://www.readbyqxmd.com/read/27860499/premixed-insulin-analogue-compared-with-basal-plus-regimen-for-inpatient-glycemic-control
#16
Abraham Edgar Gracia-Ramos, María Del Pilar Cruz-Domínguez, Eduardo Osiris Madrigal-Santillán, José Antonio Morales-González, Eduardo Madrigal-Bujaidar, José Leopoldo Aguilar-Faisal
BACKGROUND: No previous studies have investigated the use of a premixed insulin analogue in a hospital setting. OBJECTIVE: To compare the efficacy and safety of treatment with premixed insulin analogue (insulin lispro mix 75/25, LM75/25) with the basal-plus regimen with insulin glargine in hospitalized patients with type 2 diabetes (T2D). MATERIALS AND METHODS: A randomized clinical trial in hospitalized patients with T2D and glucose >140 mg/dL on admission was performed...
November 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27852883/wound-closure-in-smoking-peripheral-arterial-disease-patients-with-treatment-refractory-ulcerations-a-12-month-follow-up-case-series
#17
Jonathan Smedley, Georgina M Michael, Yeabsera G Tamire
Despite ongoing smoking cessation efforts and optimized perfusion, failed wound closure in the presence of peripheral arterial disease (PAD) and diabetes are common. A clinical effectiveness review was conducted in actively smoking diabetic patients diagnosed with PAD, treated with serial applications of a viable intact cryopreserved human placental membrane (vCPM) (Grafix, Osiris Therapeutics Inc, Columbia, MD) for recalcitrant lower extremity ulcerations (n = 6). More than half of the patients were not candidates for revascularization...
December 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27790789/simeprevir-plus-sofosbuvir-for-eight-or-12-weeks-in-treatment-na%C3%A3-ve-and-treatment-experienced-hepatitis-c-virus-genotype-4-patients-with-or-without-cirrhosis
#18
M El Raziky, M Gamil, M K Ashour, E A Sameea, W Doss, Y Hamada, G Van Dooren, R DeMasi, S Keim, I Lonjon-Domanec, R Hammad, M S Hashim, M Hassany, I Waked
The OSIRIS study investigated efficacy and safety of simeprevir plus sofosbuvir for eight or 12 weeks in hepatitis C virus (HCV) genotype 4-infected patients with METAVIR F0-F4 fibrosis. Sixty-three patients (33 treatment-naïve and 30 peg-interferon/ribavirin (Peg-IFN/RBV)-experienced) enrolled in a partly randomized, open-label, multicentre, phase IIa study. Patients with F0-F3 fibrosis were randomized (1:1) into two groups (A1 and A2), stratified according to treatment experience and METAVIR score, to receive either eight weeks (Group A1, n=20) or 12 weeks (Group A2, n=20) of treatment...
February 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27766221/preliminary-safety-assessment-of-new-azinesulfonamide-analogs-of-aripiprazole-using-prokaryotic-models
#19
Beata Powroźnik, Karolina Słoczyńska, Krzysztof Marciniec, Paweł Zajdel, Elżbieta Pękala
Purpose: Determination of the mutagenic potential of new biologically active compounds is of great concern for preliminary toxicity testing and drug development. Methods: The mutagenic and antimutagenic effects of some quinoline- and isoquinolinesulfonamide analogs of aripiprazole (1-8), which display potent antidepressant, anxiolytic, and antipsychotic properties, were evaluated using the Vibrio harveyi assay and OSIRIS Property Explorer software. Additionally, the Ames test was used as the reference. Results: In silico prediction showed that compounds 5 (N-(3-(4-(2,3- dichlorophenyl)piperazin-1-yl)propyl)quinoline-7-sulfonamide) and 6 (N-(4-(4-(2,3- Dichlorophenyl)piperazin-1-yl)butyl)quinoline-7-sulfonamide) trigger a mutagenic structural alert...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27681807/viable-intact-cryopreserved-human-placental-membrane-for-a-non-surgical-approach-to-closure-in-complex-wounds
#20
K Suzuki, G Michael, Y Tamire
OBJECTIVE: Advances in wound treatment have yielded successful approaches to complex wound closure through plastic surgery or other staged surgical methods. However, not all patients or wounds are candidates for such increasingly rigorous levels of interventions. The exploration of non-surgical treatment options that promote anatomical and functional tissue replacement on an outpatient basis without donor site morbidity is necessary to maximise opportunities for patient mobility and rehabilitation...
October 2016: Journal of Wound Care
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