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https://www.readbyqxmd.com/read/19007502/a-novel-method-for-the-determination-of-guanfacine-in-urine-by-gas-chromatography-mass-spectrometry
#1
Carrie Haglock, Carl Wolf, Alphonse Poklis
Guanfacine (Tenex), an antihypertensive available since 1975, has recently been indicated for the treatment of attention deficit hyperactivity disorder in children (Intuniv). Because of this new usage, a gas chromatography-mass spectrometry method was developed and validated for the determination of guanfacine in urine. Guanfacine and 100 ng of protriptyline (internal standard) were extracted from 1.0 mL urine with 0.5 mL of saturated carbonate/bicarbonate buffer and 2 mL of ethyl acetate. The solvent extract was evaporated and derivatized with heptaflurobutyric anhydride in n-butyl chloride...
October 2008: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/16222911/nonstimulant-therapies-for-attention-deficit-hyperactivity-disorder-adhd-in-children-and-adults
#2
REVIEW
James G Waxmonsky
While stimulant medications are the primary pharmacological treatment for ADHD across the lifespan, a subset of patients with ADHD do not experience significant symptom relief from stimulants or can not tolerate effective stimulant doses. Psychosocial therapies, particularly behavioral modification techniques, should be considered for children with ADHD and oppositional behaviors, while Cognitive Behavioral Therapy (CBT) may be a helpful adjunct for adolescents and adults with ADHD. Among the nonstimulant medications, atomoxetine (Strattera) is the only the FDA approved option...
2005: Essential Psychopharmacology
https://www.readbyqxmd.com/read/10789379/phthalates-in-paper-and-board-packaging-and-their-migration-into-tenax-and-sugar
#3
B Aurela, H Kulmala, L Söderhjelm
Packaging samples for many kinds of foodstuffs were received from manufacturers together with basic information about the materials used in their production. Half of the 29 samples studied contained phthalates in amounts exceeding 5 mg/kg. Two types of paper bag intended for sugar and exceptionally high phthalate contents although they were flexo printed. The maximum contents of di-isobutylphthalate (DIBP) and dibutylphthalate (DBP) were 450 and 200 mg/kg, respectively. The phthalates found originated from adhesives used in the joints of the packaging...
December 1999: Food Additives and Contaminants
https://www.readbyqxmd.com/read/7860456/an-open-trial-of-guanfacine-in-the-treatment-of-attention-deficit-hyperactivity-disorder
#4
R D Hunt, A F Arnsten, M D Asbell
OBJECTIVE: Medications such as clonidine have been shown to facilitate calming, to enhance frustration tolerance, and to reduce aggression in hyperactive children. The use of guanfacine (Tenex), an alpha 2 noradrenergic agonist similar to clonidine, was studied as an alternative because of its longer excretion half-life, decreased sedative side effects, and more selective binding profile. METHOD: Thirteen psychiatric outpatients diagnosed with ADHD were rated at baseline and while taking guanfacine to determine its efficacy as a treatment for ADHD...
January 1995: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/2665757/in-vitro-cardiac-effects-and-antiarrhythmic-properties-of-guanfacine
#5
G Scholtysik, P Brugger
Guanfacine (Estulic, Tenex), a centrally acting antihypertensive, was investigated for its effects on the heart using isolated cardiac preparations and in patients for antiarrhythmic properties. The tachycardic effects of sympathetic nerve stimulation in spontaneously beating atria were concentration-dependently suppressed by guanfacine. A 50% inhibition was observed in atria from Syrian hamsters, guinea-pigs and rabbits with 1, 5.4 and 20 nmol/l, respectively. In guinea-pig atria the concentration-response curve of guanfacine was shifted to the right in a parallel manner by rauwolscine (pA2 8...
April 1989: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/730814/determination-of-trace-organic-impurities-in-water-using-thermal-desorption-from-xad-resin
#6
J P Ryan, J S Fritz
A small water sample (20 to 250 ml) is passed through a small tube containing XAD-4 resin; this effectively retains the organic impurities present in the water. This tube is connected to the permanent apparatus and the sorbed organics are thermally transferred to a small Tenex pre-column while the water vapor is vented. The pre-column is closed off, preheated to 275--280 degrees C, and then a valve is opened to plug-inject the vaporized sample into a gas chromatography. The procedure works well for a variety of model organic compounds added to the water and can be used for the analysis of actual water samples...
October 10, 1978: Journal of Chromatographic Science
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