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REM sleep behavior disorders

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https://www.readbyqxmd.com/read/28012950/a-dose-effect-of-mutations-in-the-gba-gene-on-parkinson-s-disease-phenotype
#1
Avner Thaler, Tanya Gurevich, Anat Bar Shira, Mali Gana Weisz, Elissa Ash, Tamara Shiner, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS: We assessed motor, cognitive, olfactory and autonomic functions as well as demographic data and medical history in a cohort of Ashkenazi Jewish PD patients who were screened for seven common mutations in the GBA gene...
December 16, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28007355/isolated-rapid-eye-movement-sleep-without-atonia-in-amyotrophic-lateral-sclerosis
#2
Monica Puligheddu, Patrizia Congiu, Debora Aricò, Francesco Rundo, Giuseppe Borghero, Francesco Marrosu, Maria Livia Fantini, Raffaele Ferri
OBJECTIVE: The aim of this study was to quantitatively analyze, with the most recent and advanced tools, the presence of periodic leg movements during sleep (PLMS) and/or rapid eye movement (REM) sleep without atonia (RSWA), in a group of patients with amyotrophic lateral sclerosis (ALS), and to assess their eventual correlation with the clinical severity of the disease. METHODS: Twenty-nine ALS patients were enrolled (mean age 63.6 years) along with 28 age-matched "normal" controls (mean age 63...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27957531/noradrenaline-from-locus-coeruleus-neurons-acts-on-pedunculo-pontine-neurons-to-prevent-rem-sleep-and-induces-its-loss-associated-effects-in-rats
#3
Mudasir Ahmad Khanday, Bindu I Somarajan, Rachna Mehta, Birendra Nath Mallick
Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS regulation and function in health and diseases remained to be confirmed in vivo. Using tyrosine hydroxylase (TH)-siRNA and virus-coated TH-shRNA in normal freely moving rats, we downregulated NA synthesis in locus coeruleus (LC) REM-OFF neurons in vivo...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27923426/periodic-limb-movements-during-sleep-mimicking-rem-sleep-behavior-disorder
#4
Carles Gaig, Alex Iranzo, Montserrat Pujo, Hernando Perez, Joan Santamaria
STUDY OBJECTIVE: To describe a group of patients referredbecause of abnormal sleep behaviors that were suggestive ofREM sleep behavior disorder (RBD) in whom videopolysomnographyruled out RBD and showed the reportedbehaviors associated with vigorous periodic limb movementsduring sleep (PLMS). METHODS: Clinical history and video-polysomnography reviewof patients identified during routine visits in a sleepcenter. RESULTS: Patients were fifteen men and two women with a median age of 66 (range 48-77) years...
November 28, 2016: Sleep
https://www.readbyqxmd.com/read/27923423/comparison-between-automatic-and-visual-scorings-of-rem-sleep-without-atonia-for-the-diagnosis-of-rem-sleep-behavior-disorder-in-parkinson-disease
#5
Michela Figorilli, Raffaele Ferri, Maurizio Zibetti, Patricia Beudin, Monica Puligheddu, Leonardo Lopiano, Alessandro Cicolin, Frank Durif, Ana Marques, Maria Livia Fantini
STUDY OBJECTIVES: To compare three different methods, two visual and one automatic, for the quantification of rapid eye movement (REM) sleep without atonia (RSWA) in the diagnosis of REM sleep behavior disorder (RBD) in Parkinson's disease (PD) patients. METHODS: Sixty-two consecutive patients with idiopathic PD underwent videopolysomnographic recording and showed more than 5 minutes of REM sleep. The electromyogram (EMG) during REM sleep was analyzed by means of two visual methods (Montréal and SINBAR) and one automatic analysis (REM Atonia Index or RAI)...
November 28, 2016: Sleep
https://www.readbyqxmd.com/read/27905363/-sleep-disorders-in-the-early-stage-of-parkinson-s-disease-in-untreated-patients
#6
N A Amosova, I G Smolentseva, P M Guseinova, O A Maslyuk, E L Gavrilov
Disorders of sleep and wakefulness occur in about 60-98% of patients with Parkinson's disease (PD). The majority of research on the scale and nature of the disorders was performed in patients treated with antiparkinsonian drugs, and, therefore, the true picture of sleep disorders was interfering with side effects of therapy. The spectrum of these disorders in PD patients is broad and includes insomnia, parasomnia and hypersomnia. The main symptoms of insomnia are difficulty in maintaining sleep, associated with nocturia, rapid eye movement (REM) sleep behavior disorder (RBD), night cramps, akinesia and tremor...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27898200/transcranial-sonography-in-idiopathic-rem-sleep-behavior-disorder-and-multiple-system-atrophy
#7
Xudong Li, Shuang Xue, Shuhong Jia, Zhi Zhou, Yanan Qiao, Chunlei Hou, Kun Wei, Wenjing Zheng, Pei Rong, Jinsong Jiao
AIMS: We investigated preclinical abnormalities revealed by transcranial sonography (TCS) in patients with idiopathic REM sleep behavior disorder (iRBD) compared with those revealed in patients with multiple system atrophy (MSA) or Parkinson's disease (PD) and in normal controls. METHODS: Twenty-two patients with iRBD, 21 patients with MSA, 22 patients with PD and 21 normal controls were included in this study. All participants underwent one night of video-polysomnography (PSG) monitoring, and the sleep parameters were analyzed using Polysmith software and by visual analysis...
November 29, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27894921/alterations-of-awake-eeg-in-idiopathic-rem-sleep-behavior-disorder-without-cognitive-impairment
#8
Young Rong Bang, Hong Jun Jeon, Soyoung Youn, In-Young Yoon
The aim of this study was to find electroencephalographic (EEG) changes in subjects with drug-naïve idiopathic rapid eye movement sleep behavior disorder (iRBD) who had no cognitive impairment. A total of 57 iRBD patients confirmed by polysomnography (PSG) and 33 sex and age-matched healthy controls were included and their waking EEG was recorded from five cortical regions for 15min. Power spectral analyses by fast Fourier transforms were performed on EEG data. In PSG data, the iRBD patients showed sleep disturbances of short total sleep time, decreased sleep efficiency, increased sleep latency and frequent awakening compared to controls...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27886007/sleep-wake-profile-in-dementia-with-lewy-bodies-alzheimer-s-disease-and-normal-aging
#9
Annachiara Cagnin, Federica Fragiacomo, Giulia Camporese, Matteo Turco, Cinzia Bussè, Mario Ermani, Sara Montagnese
BACKGROUND: Alterations of the sleep-wake cycle are common features of neurodegenerative dementia. OBJECTIVES: To study differences in sleep-wake profiles in dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and healthy controls. METHODS: 30 DLB and 32 AD patients, and 33 healthy elderly participants were studied. Patients were evaluated for global cognitive impairment, extrapyramidal signs, fluctuations of attention, and behavioral disorders...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27880010/abnormal-baseline-brain-activity-in-parkinson-s-disease-with-and-without-rem-sleep-behavior-disorder-a-resting-state-functional-mri-study
#10
Dan Li, Peiyu Huang, Yufeng Zang, Yuting Lou, Zhidong Cen, Quanquan Gu, Min Xuan, Fei Xie, Zhiyuan Ouyang, Bo Wang, Minming Zhang, Wei Luo
PURPOSE: To investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PD patients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD. MATERIALS AND METHODS: Eighteen PD patients with RBD, 16 patients without RBD, and 19 age- and gender-matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3...
November 23, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#11
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27855738/sexsomnia-a-specialized-non-rem-parasomnia
#12
Anne-Laure Dubessy, Smaranda Leu-Semenescu, Valérie Attali, Jean-Baptiste Maranci, Isabelle Arnulf
OBJECTIVE: To describe patients with sexsomnia and to contrast their clinical and sleep measures with those of healthy controls and sleepwalkers. METHODS: Subjects referred for sexsomnia and for sleepwalking/night terror were interviewed, completed the Paris Arousal Disorder Severity Scale (PADSS) and were monitored one to two nights with video-polysomnography. RESULTS: Seventeen patients (70.6% male, aged 17 to 76 years) had sexsomnia, with amnestic fondling of the bed partner (n=11), complete sexual intercourse (n=8), masturbation (n=8) and spontaneous orgasm (n=1)...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27855735/pareidolias-in-rem-sleep-behavior-disorder-a-possible-predictive-marker-of-lewy-body-diseases
#13
Taeko Sasai-Sakuma, Yoshiyuki Nishio, Kayoko Yokoi, Etsuro Mori, Yuichi Inoue
STUDY OBJECTIVES: To investigate conditions and clinical significance of pareidolias in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: This cross-sectional study examined 202 patients with idiopathic rapid eye movement sleep behavior disorder (66.8±8.0 yr, 58 female) and 46 healthy control subjects (64.7±5.8 yr, 14 female). They underwent the Pareidolia test, a newly developed instrument for evoking pareidolias, video-polysomnography, olfactory tests, and Addenbrooke's cognitive examination - revised...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27853964/brain-pathway-differences-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#14
Mina Ansari, Farzaneh Rahmani, Mahsa Dolatshahi, Atefe Pooyan, Mohammad Hadi Aarabi
PURPOSE: REM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder. METHODS: Diffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD...
November 16, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27852786/electrophysiological-evidence-for-alternative-motor-networks-in-rem-sleep-behavior-disorder
#15
Marc Hackius, Esther Werth, Oguzkan Sürücü, Christian R Baumann, Lukas L Imbach
: Patients with Parkinson's disease (PD) and REM sleep behavior disorder (RBD) show mostly unimpaired motor behavior during REM sleep, which contrasts strongly to coexistent nocturnal bradykinesia. The reason for this sudden amelioration of motor control in REM sleep is unknown, however. We set out to determine whether movements during REM sleep are processed by different motor networks than movements in the waking state. We recorded local field potentials in the subthalamic nucleus (STN) and scalp EEG (modified 10/20 montage) during sleep in humans with PD and RBD...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27810712/sleep-architecture-parameters-as-a-putative-biomarker-of-suicidal-ideation-in-treatment-resistant-depression
#16
Rebecca A Bernert, David A Luckenbaugh, Wallace C Duncan, Naomi G Iwata, Elizabeth D Ballard, Carlos A Zarate
BACKGROUND: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD). METHODS: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27810184/caring-burden-of-rem-sleep-behavior-disorder-spouses-health-and-marital-relationship
#17
S P Lam, C C Y Wong, S X Li, J H Zhang, J W Chan, J Y Zhou, Y P Liu, M W M Yu, Y K Wing
OBJECTIVES: Idiopathic REM sleep behavior disorder (iRBD) is noxious due to the high prevalence of sleep-related injuries to patients and their bed-partners. In this study, we aimed to investigate the impact of patients' RBD symptoms on their spouses, in terms of the quality of sleep, and physical, mental and marital aspects. METHOD: A cross-sectional study comparing spouses of iRBD patients to the spouses of the age-and-sex-matched OSAS patients. RESULTS: 40 iRBD patients and their spouses (patients' age 66...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27807183/efficacy-of-sodium-oxybate-on-rem-sleep-behavior-disorder-in-a-patient-with-narcolepsy-type-1
#18
Geert Mayer
No abstract text is available yet for this article.
December 13, 2016: Neurology
https://www.readbyqxmd.com/read/27793660/reduced-expression-of-%C3%AE-5gabaa-receptors-elicits-autism-like-alterations-in-eeg-patterns-and-sleep-wake-behavior
#19
Lia Mesbah-Oskui, Antonello Penna, Beverley A Orser, Richard L Horner
A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5(-/-)) exhibit autism-like behaviors and both enhanced and impaired learning and memory, depending on the behavioral task. The aim of this study was to examine the electroencephalogram (EEG) activity and sleep-wake behaviors in Gabra5(-/-) mice and wild-type mice. In addition, since some individuals with ASD can exhibit elevated innate immune response, mice were treated with lipopolysaccharide (LPS; 125mg/kg intraperitoneal injection) or vehicle and EEG and sleep-wake patterns were assessed...
October 26, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27773979/self-reported-sleep-in-older-african-americans-and-white-americans
#20
Arlener D Turner, Andrew S Lim, Sue E Leurgans, David A Bennett, Aron S Buchman, Lisa L Barnes
OBJECTIVE: Assess the relationship of self-reported sleep quality and possible sleep disorders with disability in a racially diverse sample of community-dwelling older adults. METHODS: Participants included 943 non-demented older African Americans (n=452) and Whites (n=491) from two cohort studies, the Minority Aging Research Study (MARS) and the Rush Memory and Aging Project (MAP). Participants completed a 32-item questionnaire assessing sleep quality and the possible presence of three sleep disorders (sleep apnea, restless leg syndrome [RLS] and REM behavior disorder [RBD])...
October 20, 2016: Ethnicity & Disease
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