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REM sleep behavior disorders

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https://www.readbyqxmd.com/read/29784561/parkinson-s-disease-phenotype-is-influenced-by-the-severity-of-the-mutations-in-the-gba-gene
#1
Avner Thaler, Noa Bregman, Tanya Gurevich, Tamara Shiner, Yonatan Dror, Ofir Zmira, Ziv Gan-Or, Anat Bar-Shira, Mali Gana-Weisz, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the glucocerebrosidase (GBA) gene are divided into mild and severe (mGBA, sGBA) based on their contribution to the phenotype of Gaucher disease (GD) among homozygotes. We conducted a longitudinal analysis of Parkinson's disease (PD) patients carrying mutations in the GBA gene to better characterize genotype-phenotype correlations. METHODS: Patients underwent a comprehensive assessment of medical, neurological, cognitive and non-motor functions...
May 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29784534/presynaptic-dopaminergic-neuroimaging-in-rem-sleep-behavior-disorder-a-systematic-review-and-meta-analysis
#2
REVIEW
Matteo Bauckneht, Andrea Chincarini, Fabrizio De Carli, Michele Terzaghi, Silvia Morbelli, Flavio Nobili, Dario Arnaldi
The presence of polysomnography-confirmed REM sleep behavior disorder (RBD) is the stronger risk factor for having prodromal Parkinson disease (PD), followed by abnormal presynaptic dopaminergic radionuclide neuroimaging. Aim of the review is to conduct a meta-analysis of literature data regarding presynaptic dopaminergic neuroimaging in RBD. A literature search was conducted, resulting in 16 papers that met the inclusion criteria. Clinical and neuroimaging data were extracted. The studies are heterogeneous, especially for neuroimaging methodology...
April 22, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29779682/predicting-alpha-synuclein-pathology-by-rem-sleep-behavior-disorder-diagnosis
#3
David R Shprecher, Charles H Adler, Nan Zhang, Joseph G Hentz, Geidy E Serrano, Brittany N Dugger, Holly A Shill, Rodolfo Savica, John N Caviness, Marwan N Sabbagh, Christine M Belden, Erika Driver-Dunckley, Shyamal H Mehta, Lucia I Sue, Kathryn J Davis, Edward Zamrini, Thomas G Beach
Inability to accurately diagnose Lewy type alpha-synucleinopathy (LTS) pre-mortem has been a major obstacle to clinical care and research. Probable REM sleep behavior disorder (PRBD) diagnosed with support of instruments such as the Mayo Sleep Questionnaire (MSQ) may provide a cost effective means of predicting LTS. Since 2007, 602 subjects in the Arizona Study of Aging and Neurodegenerative Disorders had clinician assessment for PRBD (298 with, 304 without support of the MSQ), completed cognitive and movement examinations, and had neuropathological assessment...
May 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29773203/validation-of-semiautomatic-scoring-of-rem-sleep-without-atonia-in-patients-with-rbd
#4
D Guttowski, G Mayer, W H Oertel, K Kesper, T Rosenberg
OBJECTIVE/BACKGROUND: To evaluate REM sleep without atonia (RSWA) in REM sleep behavior disorder (RBD) several automatic algorithms have been developed. We aimed to validate our algorithm (Mayer et al., 2008) in order to assess the following: (1). capability of the algorithm to differentiate between RBD, night terror (NT), somnambulism (SW), Restless legs syndrome (RLS), and obstructive sleep apnea (OSA), (2). the cut-off values for short (SMI) and long muscle activity (LMI), (3). which muscles qualify best for differential diagnosis, and (4)...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29753639/nrem-parasomnias-a-treatment-approach-based-upon-a-retrospective-case-series-of-512-patients
#5
Panagis Drakatos, Lucy Marples, Rexford Muza, Sean Higgins, Nadia Gildeh, Raluca Macavei, Eptehal M Dongol, Alexander Nesbitt, Ivana Rosenzweig, Elaine Lyons, Grainne d'Ancona, Joerg Steier, Adrian J Williams, Brian D Kent, Guy Leschziner
BACKGROUND: Non-REM parasomnias are not uncommon conditions in the general population. Current treatment options are based on small case series and reports. In this study, we aimed to present the clinical experience from a large cohort of patients. PATIENTS: Five hundred and twelve patients with Non-REM parasomnia or parasomnia overlap disorder (POD), who had undergone a video polysomnography and were exposed to treatment, were retrospectively identified. Treatment outcome was assessed based on patients' reports, and treatment approach on a locally accepted hierarchy of interventions...
April 10, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29747690/a53t-%C3%AE-synuclein-overexpression-in-murine-locus-coeruleus-induces-parkinson-s-disease-like-pathology-in-neurons-and-glia
#6
Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke, Wolfgang Hermann Oertel
Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson's disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavior disorder. This study was designed to establish the first locus coeruleus α-synucleinopathy mouse model, which should provide sufficient information about the time-course of noradrenergic neurodegeneration, replicate cardinal histopathological features of the human Parkinson's disease neuropathology and finally lead to robust histological markers, which are sufficient to assess the pathological changes in a quantitative and qualitative way...
May 10, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29740055/cardiac-sympathetic-activity-differentiates-idiopathic-and-symptomatic-rapid-eye-movement-sleep-behaviour-disorder
#7
Lucie Barateau, Isabelle Jaussent, Régis Lopez, Elisa Evangelista, Sofiene Chenini, Meriem Benkiran, Denis Mariano-Goulart, Yves Dauvilliers
The pathophysiology of rapid eye movement sleep behavior disorder (RBD) associated with narcolepsy type 1 (NT1) is still poorly understood, potentially distinct from idiopathic RBD (iRBD), but may share affected common pathways. We investigated whether MIBG cardiac uptake differs between iRBD and NT1 comorbid with RBD. Thirty-four patients with NT1-RBD and 15 patients with iRBD underwent MIBG cardiac scintigraphy. MIBG uptake was measured by calculating the early and delayed heart to mediastinum (H/M) ratios...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735555/genetic-activation-inactivation-and-deletion-reveal-a-limited-and-nuanced-role-for-somatostatin-containing-basal-forebrain-neurons-in-behavioral-state-control
#8
Christelle Anaclet, Roberto De Luca, Anne Venner, Olga Malyshevskaya, Michael Lazarus, Elda Arrigoni, Patrick M Fuller
Recent studies have identified an especially important role for basal forebrain GABAergic (BFVGAT ) neurons in the regulation of behavioral waking and fast cortical rhythms associated with cognition. However, BFVGAT neurons comprise several neurochemically and anatomically distinct sub-populations, including parvalbumin- and somatostatin-containing BFVGAT neurons (BFParv and BFSOM ), and it was recently reported that optogenetic activation of BFSOM neurons increases the probability of a wakefulness to non-rapid-eye movement (NREM) sleep transition when stimulated during the animal's rest period...
May 7, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29734991/violent-parasomnia-with-recurrent-biting-and-surgical-interventions-case-report-and-differential-diagnosis
#9
Nilam Danish, Imran S Khawaja, Carlos H Schenck
A case is reported of recurrent, injurious self-biting during sleep, requiring surgical interventions, in a 55-year-old obese man with a 20-year history of violent complex parasomnia, with greatly increased frequency and severity of episodes induced by work stress during the preceding 3 years. After clinical evaluation and overnight, hospital-based video-polysomnography, the cause of the chronic injurious parasomnia was deemed to be a non-rapid eye movement (NREM) sleep parasomnia comorbid with severe obstructive sleep apnea...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29734988/change-in-cognition-and-other-non-motor-symptoms-with-obstructive-sleep-apnea-treatment-in-parkinson-disease
#10
Marta Kaminska, Victoria P Mery, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, Priti Gros, R John Kimoff
STUDY OBJECTIVES: Parkinson disease (PD) non-motor symptoms are associated with sleep disorders and impair quality of life. Our objective was to assess the effect of obstructive sleep apnea (OSA) treatment using continuous positive airway pressure (CPAP) on PD non-motor symptoms. METHODS: In this prospective observational study, 67 patients with idiopathic PD underwent polysomnography. Those with moderate-severe OSA were offered CPAP therapy. Subjects were divided into those without OSA (OSA-), and those with OSA (OSA+)...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29724601/longstanding-disease-free-survival-in-idiopathic-rem-sleep-behavior-disorder-is-neurodegeneration-inevitable
#11
Chun Yao, Seyed-Mohammad Fereshtehnejad, Benjamin K Dawson, Amelie Pelletier, Ziv Gan-Or, Jean-François Gagnon, Jacques Y Montplaisir, Ronald B Postuma
INTRODUCTION: Studies estimate that >80% of patients with idiopathic REM sleep behavior disorder (iRBD) eventually develop parkinsonism or dementia. However, a small group remains disease-free for long periods, raising the question of whether they truly have prodromal disease. METHODS: We selected subjects with iRBD who were diagnosed at least 10 years previously, and were still disease free (longstanding iRBD) (n = 11). We compared them to 'early converters' (n = 27) defined as those who phenoconverted to parkinsonism or dementia within 4 years after diagnosis, and to age- and sex-matched healthy controls (n = 68)...
April 4, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29686598/sleep-related-problems-as-a-nonmotor-symptom-of-dentatorubropallidoluysian-atrophy
#12
Hyeyun Kim, Ji Young Yun, Kyoung-Gyu Choi, Heasoo Koo, Hyun Jeong Han
Dentatorubropallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expansion of a cytosine-adenine-guanine (CAG) repeat encoding a polyglutamine tract in the atrophin-1 protein. Unlike other CAG repeat diseases, sleep related problems have not been reported in patients with DRPLA. There was a 65-year-old man and his family with DRPLA. They suffered from seizure, gait disturbance, and cognitive decline. The patients commonly showed dream enacting sleep disorder, insomnia. The results from overnight polysomnography showed rapid eye movement (REM) without atonia in patients with DRPLA...
April 23, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29679174/sleep-abnormalities-in-multiplesystem-atrophy
#13
REVIEW
Valérie Cochen De Cock
PURPOSE OF REVIEW: The purpose of this review was to explore the different sleep disorders associated with MSA, their mechanisms, and their treatments. RECENT FINDINGS: Stridor is a red flag for the diagnosis of MSA. Recent findings show that its presence in early stage of the disease is associated with a reduction in life expectancy. Its management should be fast and adapted. Its treatment with continuous positive airway pressure or tracheostomy is efficacious...
April 20, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29675716/disturbances-of-sleep-and-alertness-in-parkinson-s-disease
#14
REVIEW
Aleksandar Videnovic
PURPOSE OF REVIEW: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29669910/the-clinical-relevance-of-cognitive-impairment-in-rem-sleep-behavior-disorder
#15
EDITORIAL
Dario Arnaldi, Flavio Nobili
No abstract text is available yet for this article.
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29669906/cortical-and-subcortical-gray-matter-bases-of-cognitive-deficits-in-rem-sleep-behavior-disorder
#16
Shady Rahayel, Ronald B Postuma, Jacques Montplaisir, Daphné Génier Marchand, Frédérique Escudier, Malo Gaubert, Pierre-Alexandre Bourgouin, Julie Carrier, Oury Monchi, Sven Joubert, Frédéric Blanc, Jean-François Gagnon
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#17
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29664048/effect-of-rapid-eye-movement-sleep-behavior-disorder-on-obstructive-sleep-apnea-severity-and-cognition-of-parkinson-s-disease-patients
#18
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29644271/venlafaxine-induced-rem-sleep-behavioral-disorder-presenting-as-two-fractures
#19
R Ryan Williams, Gustavo Sandigo
Rapid eye movement (REM) sleep behavioral disorder is characterized by the absence of muscular atonia during REM sleep. In this disorder, patients can violently act out their dreams, placing them at risk for traumatic fractures during these episodes. REM sleep behavioral disorder (RBD) can be a sign of future neurodegenerative disease and has also been found to be a side effect of certain psychiatric medications. We present a case of venlafaxine-induced RBD in a 55 year old female who presented with a 13 year history of intermittent parasomnia and dream enactment in addition to a recent history of two fractures requiring intervention...
October 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29618627/baseline-symptoms-and-basal-forebrain-volume-predict-future-psychosis-in-early-parkinson-disease
#20
Matthew J Barrett, Jamie C Blair, Scott A Sperling, Mark E Smolkin, T Jason Druzgal
OBJECTIVE: Determining baseline predictors of future psychosis in Parkinson disease (PD) may identify those at risk for more rapidly progressive disease, i.e., a more malignant PD subtype. METHODS: This cohort study evaluated 423 patients with newly diagnosed PD collected as part of the Parkinson's Progression Markers Initiative. Psychotic symptoms were assessed with the Movement Disorders Society-Unified Parkinson Disease Rating Scale item 1.2, which assesses hallucinations and psychosis over the past week...
May 1, 2018: Neurology
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