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REM sleep behavior disorders

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https://www.readbyqxmd.com/read/28513079/rem-sleep-behavior-disorder-in-parkinson-s-disease-and-other-synucleinopathies
#1
REVIEW
Erik K St Louis, Angelica R Boeve, Bradley F Boeve
Rapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography. Rapid eye movement sleep behavior disorder may be idiopathic or symptomatic and in both settings is highly associated with synucleinopathy neurodegeneration, especially Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure...
May 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28482056/rem-sleep-eeg-instability-in-rem-sleep-behavior-disorder-and-clonazepam-effects
#2
Raffaele Ferri, Francesco Rundo, Alessandro Silvani, Marco Zucconi, Oliviero Bruni, Luigi Ferini-Strambi, Giuseppe Plazzi, Mauro Manconi
Study Objectives: We aimed to analyze quantitatively REM sleep EEG in controls, drug-naïve idiopathic REM sleep behavior disorder patients (iRBD), and iRBD patients treated with clonazepam. Methods: Twenty-nine drug-naïve iRBD patients (mean age 68.2 years), 14 iRBD patients under chronic clonazepam therapy (mean age 66.3 years) and 21 controls (mean age 66.8 years) were recruited. Power spectra were obtained from sleep EEG (central derivation), using a 2-second sliding window, with 1-second steps...
May 6, 2017: Sleep
https://www.readbyqxmd.com/read/28468843/skin-nerve-phosphorylated-%C3%AE-synuclein-deposits-in-idiopathic-rem-sleep-behavior-disorder
#3
Elena Antelmi, Vincenzo Donadio, Alex Incensi, Giuseppe Plazzi, Rocco Liguori
OBJECTIVE: To test if phosphorylated α-synuclein (p-α-syn) deposits can be detected by means of skin biopsy in patients with idiopathic REM sleep behavior disorder (iRBD) as a potential early histopathologic marker of impending synucleinopathy. METHODS: Proximal (cervical) and distal (legs) samples of skin biopsy were obtained from 12 patients with polysomnographically confirmed iRBD and 55 sex- and age-matched healthy controls (HC). P-α-syn deposits were assessed with a monoclonal antibody against p-α-syn at serine 129, disclosed by an immunofluorescence method...
May 3, 2017: Neurology
https://www.readbyqxmd.com/read/28466429/sleep-disturbances-in-the-prodromal-stage-of-parkinson-disease
#4
REVIEW
Ahmed Al-Qassabi, Seyed-Mohammad Fereshtehnejad, Ronald B Postuma
Decades of research on neurodegenerative diseases such as Parkinson's disease (PD) have shifted our focus from clinical symptomatic stages to one step earlier, the prodromal stage. There is convincing evidence showing that sleep disorders such as excessive daytime somnolence, insomnia, obstructive sleep apnea, and particularly REM sleep behavior disorder (RBD) are potential prodromal features starting years and decades before conversion to PD. This review aims to provide an overview on various sleep disorders as prodromal features of PD...
June 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28455701/chronic-rem-sleep-restriction-in-juvenile-male-rats-induces-anxiety-like-behavior-and-alters-monoamine-systems-in-the-amygdala-and-hippocampus
#5
Janaína da Silva Rocha-Lopes, Ricardo Borges Machado, Deborah Suchecki
Adolescence is marked by major physiological changes, including those in the sleep-wake cycle, such as phase delay, which may result in reduced sleep hours. Sleep restriction and/or deprivation in adult rats activate stress response and seem to be a risk factor for triggering emotional disorders. In the present study, we sought to evaluate the behavioral and neurobiological consequences of prolonged REM sleep restriction in juvenile male rats. Immediately after weaning, on postnatal day 21, three males from each litter were submitted to REM sleep deprivation and the other three animals were maintained in their home-cages...
April 28, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28453473/prodromal-dementia-with-lewy-bodies-and-prodromal-alzheimer-s-disease-a-comparison-of-the-cognitive-and-clinical-profiles
#6
Dilman Sadiq, Tim Whitfield, Lean Lee, Tim Stevens, Sergi Costafreda, Zuzana Walker
BACKGROUND: Dementia must be diagnosed accurately and early in the disease course to allow pathology-specific treatments to be effective. Dementia with Lewy bodies (DLB) is often misdiagnosed as Alzheimer's disease (AD), especially at the prodromal stage. OBJECTIVE: To compare the clinical and neuropsychological profiles of Mild Cognitive Impairment (MCI) patients who, at follow-up, progressed to AD (retrospectively AD-MCI) or DLB (retrospectively DLB-MCI) or remained MCI...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28449901/diagnostic-rem-sleep-muscle-activity-thresholds-in-patients-with-idiopathic-rem-sleep-behavior-disorder-with-and-without-obstructive-sleep-apnea
#7
Stuart J McCarter, Erik K St Louis, David J Sandness, Ethan J Duwell, Paul C Timm, Bradley F Boeve, Michael H Silber
OBJECTIVES: We aimed to determine whether visual and automated rapid eye movement (REM) sleep without atonia (RSWA) methods could accurately diagnose patients with idiopathic REM sleep behavior disorder (iRBD) and comorbid obstructive sleep apnea (OSA). METHODS: In iRBD patients (n = 15) and matched controls (n = 30) with and without OSA, we visually analyzed RSWA phasic burst durations, phasic, tonic, and "any" muscle activity by 3-s mini-epochs, phasic activity by 30-s (AASM rules) epochs, and automated REM atonia index (RAI)...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28429825/validation-of-the-mds-research-criteria-for-prodromal-parkinson-s-disease-longitudinal-assessment-in-a-rem-sleep-behavior-disorder-rbd-cohort
#8
Seyed-Mohammad Fereshtehnejad, Jacques Y Montplaisir, Amelie Pelletier, Jean-François Gagnon, Daniela Berg, Ronald B Postuma
BACKGROUND: Recently, the International Parkinson and Movement Disorder Society introduced the prodromal criteria for PD. Objectives Our study aimed to examine diagnostic accuracy of the criteria as well as the independence of prodromal markers to predict conversion to PD or dementia with Lewy bodies. METHODS: This prospective cohort study was performed on 121 individuals with rapid eye movement sleep behavior disorder who were followed annually for 1 to 12 years...
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28409245/snca-3-utr-genetic-variants-in-patients-with-parkinson-s-disease-and-rem-sleep-behavior-disorder
#9
M Toffoli, E Dreussi, E Cecchin, M Valente, N Sanvilli, M Montico, S Gagno, M Garziera, M Polano, M Savarese, G Calandra-Buonaura, F Placidi, M Terzaghi, G Toffoli, G L Gigli
REM sleep behavior disorder (RBD) is an early marker of Parkinson's disease (PD); however, it is still unclear which patients with RBD will eventually develop PD. Single nucleotide polymorphisms (SNPs) in the 3'untranslated region (3'UTR) of alpha-synuclein (SNCA) have been associated with PD, but at present, no data is available about RBD. The 3'UTR hosts regulatory regions involved in gene expression control, such as microRNA binding sites. The aim of this study was to determine RBD specific genetic features associated to an increased risk of progression to PD, by sequencing of the SNCA-3'UTR in patients with "idiopathic" RBD (iRBD) and in patients with PD...
April 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28389588/probable-rem-sleep-behavior-disorder-and-risk-of-stroke-a-prospective-study
#10
Chaoran Ma, Milena Pavlova, Yesong Liu, Ying Liu, Chunmei Huangfu, Shouling Wu, Xiang Gao
OBJECTIVE: To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort. METHODS: The study included 12,003 participants (mean age 54.0 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury at baseline (2012). We determined pRBD using a validated REM sleep behavior disorder (RBD) questionnaire in 2012. Incident stroke cases were confirmed by review of medical records...
May 9, 2017: Neurology
https://www.readbyqxmd.com/read/28387681/prevalence-of-prodromal-parkinson-s-disease-as-defined-by-mds-research-criteria-among-elderly-patients-undergoing-colonoscopy
#11
Skorvanek Matej, Ladomirjakova Zuzana, Han Vladimir, Lesko Norbert, Feketeova Eva, Jarcuskova Dominika, Repkova Barbora, Spisak Peter, Urbancikova Zuzana, Vargova Adriana, Gombosova Laura, Zakuciova Maria, Veseliny Eduard, Trebuna Frantisek, Mechirova Eva, Gdovinova Zuzana
BACKGROUND: Gastrointestinal symptoms are a well-recognized and common premotor feature of Parkinson's disease (PD). Moreover, multiple studies have assessed the value of colonic α-synuclein as a potential marker of prodromal PD. Recently, the International Parkinson and Movement Disorders Society (MDS) defined research criteria for prodromal PD. OBJECTIVE: The aim of our study was to test the MDS research criteria in patients undergoing diagnostic colonoscopies as potential candidates for inclusion in prospective trials evaluating colonic biopsies as a potential biomarker of prodromal PD...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28375912/disorders-of-taste-and-smell
#12
Ronald DeVere
PURPOSE OF REVIEW: This article aims to educate clinical neurologists on the importance of taste and smell disorders in clinical neurology. These disorders commonly occur in head trauma, multiple sclerosis, seizure disorders, and neurodegenerative diseases such as idiopathic Parkinson disease and dementia, mild cognitive impairment, and Alzheimer disease, just to name a few. This article covers the basic anatomy of smell and taste, notes the important points of taking a proper history, and discusses smell and taste testing, which are inexpensive, minimally time-consuming procedures...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28367113/transcriptome-analysis-reveals-altered-expression-of-memory-and-neurotransmission-associated-genes-in-the-rem-sleep-deprived-rat-brain
#13
Santosh C Narwade, Birendra N Mallick, Deepti D Deobagkar
Sleep disorders are associated with cognitive impairment. Selective rapid eye movement sleep (REMS) deprivation (REMSD) alters several physiological processes and behaviors. By employing NGS platform we carried out transcriptomic analysis in brain samples of control rats and those exposed to REMSD. The expression of genes involved in chromatin assembly, methylation, learning, memory, regulation of synaptic transmission, neuronal plasticity and neurohypophysial hormone synthesis were altered. Increased transcription of BMP4, DBH and ATP1B2 genes after REMSD supports our earlier findings and hypothesis...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28366329/sodium-oxybate-for-idiopathic-rem-sleep-behavior-disorder-a-report-on-two-patients
#14
Keivan Kaveh Moghadam, Fabio Pizza, Alberto Primavera, Raffaele Ferri, Giuseppe Plazzi
BACKGROUND: REM-sleep behavior disorder (RBD) therapy is based on small to medium-sized case series, as no large controlled clinical trials have been performed. The most used and widely recognized effective drugs are clonazepam and melatonin, with anecdotal reports on the potential benefit of other drug classes. METHODS: We report on two patients suffering from idiopathic RBD presenting with almost nightly complex and violent episodes, refractory to conventional drugs...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28364501/comparison-between-automatic-and-visual-scorings-of-rem-sleep-without-atonia-for-the-diagnosis-of-rem-sleep-behavior-disorder-in-parkinson-disease
#15
Michela Figorilli, Raffaele Ferri, Maurizio Zibetti, Patricia Beudin, Monica Puligheddu, Leonardo Lopiano, Alessandro Cicolin, Frank Durif, Ana Marques, Maria Livia Fantini
Study Objectives: To compare three different methods, two visual and one automatic, for the quantification of rapid eye movement (REM) sleep without atonia (RSWA) in the diagnosis of REM sleep behavior disorder (RBD) in Parkinson's disease (PD) patients. Methods: Sixty-two consecutive patients with idiopathic PD underwent video-polysomnographic recording and showed more than 5 minutes of REM sleep. The electromyogram during REM sleep was analyzed by means of two visual methods (Montréal and SINBAR) and one automatic analysis (REM Atonia Index or RAI)...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364496/pareidolias-in-rem-sleep-behavior-disorder-a-possible-predictive-marker-of-lewy-body-diseases
#16
Taeko Sasai-Sakuma, Yoshiyuki Nishio, Kayoko Yokoi, Etsuro Mori, Yuichi Inoue
Study Objectives: To investigate conditions and clinical significance of pareidolias in patients with idiopathic rapid eyemovent (REM) sleep behavior disorder (iRBD). Methods: This cross-sectional study examined 202 patients with iRBD (66.8 ± 8.0 yr, 58 female) and 46 healthy control subjects (64.7 ± 5.8 years, 14 females). They underwent the Pareidolia test, a newly developed instrument for evoking pareidolias, video polysomnography, olfactory tests, and Addenbrooke's cognitive examination-revised...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364495/sexsomnia-a-specialized-non-rem-parasomnia
#17
Anne-Laure Dubessy, Smaranda Leu-Semenescu, Valérie Attali, Jean-Baptiste Maranci, Isabelle Arnulf
Introduction: To describe patients with sexsomnia and to contrast their clinical and sleep measures with those of healthy controls and sleepwalkers. Aims and Methods: Subjects referred for sexsomnia and for sleepwalking/night terror were interviewed, completed the Paris Arousal Disorder Severity Scale (PADSS), and were monitored 1-2 nights with video-polysomnography. Results: Seventeen patients (70.6% male, aged 17-76 years) had sexsomnia, with amnestic fondling of the bed partner (n = 11), complete sexual intercourse (n = 8), masturbation (n = 8), and spontaneous orgasm (n = 1)...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364455/cntnap2-knockout-rats-and-mice-exhibit-epileptiform-activity-and-abnormal-sleep-wake-physiology
#18
Alexia M Thomas, Michael D Schwartz, Michael D Saxe, Thomas S Kilduff
Study Objectives: Although recent innovations have enabled modification of the rat genome, it is unclear whether enhanced utility of rodents as human disease models will result. We compared electroencephalogram (EEG) and behavioral phenotypes of rats and mice with homozygous deletion of Cntnap2, a gene associated with cortical dysplasia-focal epilepsy (CDFE) and autism spectrum disorders (ASD). Methods: Male contactin-associated protein-like 2 (Cntnap2) knockout (KO) and wild-type (WT) rats and male Cntnap2 KO and WT mice were implanted with telemeters to record EEG, electromyogram, body temperature, and locomotor activity...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364450/detecting-the-cognitive-prodrome-of-dementia-with-lewy-bodies-a-prospective-study-of-rem-sleep-behavior-disorder
#19
Daphné Génier Marchand, Jacques Montplaisir, Ronald B Postuma, Shady Rahayel, Jean-François Gagnon
Study Objectives: Long-term studies in REM sleep behavior disorder (RBD) have shown a high rate of conversion into synucleinopathies. We aimed to prospectively follow-up a large cohort of RBD patients to identify cognitive markers for early detection of prodromal dementia. Methods: Seventy-six idiopathic RBD patients underwent polysomnography and a complete neuropsychological and neurological assessment and were then followed for a mean of 3.6 years. Cognitive characteristics at baseline were compared between patients who remained disease-free and those who developed a synucleinopathy, and between those who developed dementia first and those who developed parkinsonism first...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364416/periodic-limb-movements-during-sleep-mimicking-rem-sleep-behavior-disorder-a-new-form-of-periodic-limb-movement-disorder
#20
Carles Gaig, Alex Iranzo, Montserrat Pujol, Hernando Perez, Joan Santamaria
Study Objectives: To describe a group of patients referred because of abnormal sleep behaviors that were suggestive of rapid eye movement (REM) sleep behavior disorder (RBD) in whom video-polysomnography ruled out RBD and showed the reported behaviors associated with vigorous periodic limb movements during sleep (PLMS). Aims and Methods: Clinical history and video-polysomnography review of patients identified during routine visits in a sleep center. Results: Patients were 15 men and 2 women with a median age of 66 (range: 48-77) years...
March 1, 2017: Sleep
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