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REM sleep behavior disorders

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https://www.readbyqxmd.com/read/28329332/excessive-daytime-sleepiness-predicts-neurodegeneration-in-idiopathic-rem-sleep-behavior-disorder
#1
Junying Zhou, Jihui Zhang, Siu Ping Lam, Joey Wy Chan, Vincent Mok, Anne Chan, Shirley Xin Li, Yaping Liu, Xiangdong Tang, Wing Ho Yung, Yun Kwok Wing
Study Objectives: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). Methods: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥ 14 were defined as having EDS. Demographic, clinical and polysomnographic data were compared between iRBD patients with and without EDS...
March 16, 2017: Sleep
https://www.readbyqxmd.com/read/28329117/muscle-activity-during-sleep-in-human-subjects-rats-and-mice-towards-translational-models-of-rem-sleep-without-atonia
#2
Alessandro Silvani, Raffaele Ferri, Viviana Lo Martire, Stefano Bastianini, Chiara Berteotti, Agnese Salvadè, Giuseppe Plazzi, Marco Zucconi, Luigi Ferini-Strambi, Claudio L Bassetti, Mauro Manconi, Giovanna Zoccoli
Study Objectives: rapid-eye-movement (REM) sleep without atonia (RSWA) is a marker of REM sleep behavior disorder (RBD) and is common in narcolepsy. Available techniques for electromyogram (EMG) analysis are species-specific, limiting translational research on RSWA. We developed an automated technique based on distributions of normalized EMG values (DNE) to overcome this limitation. With DNE, we tested whether the control of neck and tibialis anterior (TA) muscles during sleep in wild-type rats and mice validly models the control of submentalis (chin) and TA muscles in healthy humans...
February 22, 2017: Sleep
https://www.readbyqxmd.com/read/28328536/neurotransmission-systems-in-parkinson-s-disease
#3
Hossein Sanjari Moghaddam, Ameneh Zare-Shahabadi, Farzaneh Rahmani, Nima Rezaei
Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein particles, known as Lewy bodies. The second most common neurodegenerative disorder, PD is widely known because of the typical motor manifestations of active tremor, rigidity, and postural instability, while several prodromal non-motor symptoms including REM sleep behavior disorders, depression, autonomic disturbances, and cognitive decline are being more extensively recognized. Motor symptoms most commonly arise from synucleinopathy of nigrostriatal pathway...
March 22, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28326036/associations-between-early-markers-of-parkinson-s-disease-and-sarcopenia
#4
Michael Drey, Sandra E Hasmann, Jan-Peter Krenovsky, Markus A Hobert, Stefanie Straub, Morad Elshehabi, Anna-Katharina von Thaler, Andreas J Fallgatter, Gerhard W Eschweiler, Ulrike Suenkel, Daniela Berg, Walter Maetzler
Introduction: Sarcopenia and Parkinson's disease (PD) are both common age-related syndromes, and there is preliminary evidence that the probability of the co-occurrence of these syndromes within one individual is higher than expected. However, it is unclear to date whether one of the syndromes induces the other, or whether there may be common underlying causes. This pilot study thus aimed at investigating the association of the features of increased risk for PD with early stage sarcopenia (ESS). Method: Two hundred and fifty-five community-dwelling individuals were recruited from the Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration (TREND) study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28322726/rem-sleep-behavior-disorder-a-review-of-the-literature-and-update-on-current-concepts
#5
REVIEW
Carlos L Rodriguez, Nattapong Jaimchariyatam, Kumar Budur
No abstract text is available yet for this article.
March 16, 2017: Chest
https://www.readbyqxmd.com/read/28315757/chronic-social-stress-leads-to-altered-sleep-homeostasis-in-mice
#6
Nadja Olini, Iru Rothfuchs, Damiano Azzinnari, Christopher R Pryce, Salome Kurth, Reto Huber
Disturbed sleep and altered sleep homeostasis are core features of many psychiatric disorders such as depression. Chronic uncontrollable stress is considered an important factor in the development of depression, but little is known on how chronic stress affects sleep regulation and sleep homeostasis. We therefore examined the effects of chronic social stress (CSS) on sleep regulation in mice. Adult male C57BL/6 mice were implanted for electrocortical recordings (ECoG) and underwent either a 10-day CSS protocol or control handling (CON)...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28303851/tonic-electromyogram-density-in-multiple-system-atrophy-with-predominant-parkinsonism-and-parkinson-s-disease
#7
Yi Wang, Yun Shen, Kang-Ping Xiong, Pei-Cheng He, Cheng-Jie Mao, Jie Li, Fu-Yu Wang, Ya-Li Wang, Jun-Ying Huang, Chun-Feng Liu
BACKGROUND: Both Parkinson's disease (PD) and multiple system atrophy (MSA) have associated sleep disorders related to the underlying neurodegenerative pathology. Clinically, MSA with predominant parkinsonism (MSA-P) resembles PD in the manifestation of prominent parkinsonism. Whether the amount of rapid eye movement (REM) sleep without atonia could be a potential marker for differentiating MSA-P from PD has not been thoroughly investigated. This study aimed to examine whether sleep parameters could provide a method for differentiating MSA-P from PD...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28288482/a-multicenter-comparative-study-of-impulse-control-disorder-in-latin-american-patients-with-parkinson-disease
#8
Carolina Candelaria Ramírez Gómez, Marcos Serrano Dueñas, Oscar Bernal, Natalia Araoz, Michel Sáenz Farret, Victoria Aldinio, Verónica Montilla, Federico Micheli
OBJECTIVES: Impulse control disorder (ICD) is a common adverse effect in patients with Parkinson disease who receive dopamine agonists; however, other factors are involved in its manifestations. To study the frequency and factors involved in the development of this adverse effect in a Latin American population, we conducted a cross-sectional multicenter study. METHODS: Two hundred fifty-five patients in 3 Latin American centers were evaluated by examination and application of scales (Unified Parkinson's Disease Rating Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale, Hoehn and Yahr, Clinical Impression of Severity Index for Parkinson's Disease)...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28268523/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#9
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261151/the-treatment-of-sleep-disorders-in-parkinson-s-disease-from-research-to-clinical-practice
#10
REVIEW
Giuseppe Loddo, Giovanna Calandra-Buonaura, Luisa Sambati, Giulia Giannini, Annagrazia Cecere, Pietro Cortelli, Federica Provini
Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's disease (PD), usually increasing in frequency over the course of the disease and disability progression. SDs include nocturnal and diurnal manifestations such as insomnia, REM sleep behavior disorder, and excessive daytime sleepiness. The causes of SDs in PD are numerous, including the neurodegeneration process itself, which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28246970/rem-theta-activity-enhances-inhibitory-control-in-typically-developing-children-but-not-children-with-adhd-symptoms
#11
Amanda Cremone, Claudia I Lugo-Candelas, Elizabeth A Harvey, Jennifer M McDermott, Rebecca M C Spencer
Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits in children with ADHD is unknown. Children with ADHD (n = 18; M age = 6.70 years) and typically developing controls (n = 15; M age = 6.73 years) completed a Go/No-Go task to measure inhibitory control and sustained attention before and after polysomnography-monitored overnight sleep...
February 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28244984/schizophrenia-like-phenotypes-in-mice-with-nmda-receptor-ablation-in-intralaminar-thalamic-nucleus-cells-and-gene-therapy-based-reversal-in-adults
#12
K Yasuda, Y Hayashi, T Yoshida, M Kashiwagi, N Nakagawa, T Michikawa, M Tanaka, R Ando, A Huang, T Hosoya, T J McHugh, M Kuwahara, S Itohara
In understanding the mechanism of schizophrenia pathogenesis, a significant finding is that drug abuse of phencyclidine or its analog ketamine causes symptoms similar to schizophrenia. Such drug effects are triggered even by administration at post-adolescent stages. Both drugs are N-methyl-d-aspartate receptor (NMDAR) antagonists, leading to a major hypothesis that glutamate hypofunction underlies schizophrenia pathogenesis. The precise region that depends on NMDAR function, however, is unclear. Here, we developed a mouse strain in which NMDARs in the intralaminar thalamic nuclei (ILN) were selectively disrupted...
February 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28231463/neural-circuitry-of-wakefulness-and-sleep
#13
REVIEW
Thomas E Scammell, Elda Arrigoni, Jonathan O Lipton
Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28228742/sleep-dependent-consolidation-of-rewarded-behavior-is-diminished-in-children-with-attention-deficit-hyperactivity-disorder-and-a-comorbid-disorder-of-social-behavior
#14
Christian D Wiesner, Ina Molzow, Alexander Prehn-Kristensen, Lioba Baving
Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation of behavior learned by probabilistic reward and whether ADHD patients with a comorbid disorder of social behavior show deficits in this memory domain, too. A group of 17 ADHD patients with comorbid disorders of social behavior aged 8-12 years and healthy controls matched for age, IQ, and handedness took part in the experiment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28226697/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#15
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Farzaneh Rahmani, Atefeh Pooyan, Mina Ansari, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#16
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28215267/a-community-based-study-of-risk-factors-for-probable-rapid-eye-movement-sleep-behavior-disorder
#17
Jian-Fang Ma, Yuan Qiao, Xiang Gao, Liang Liang, Xiao-Li Liu, Dun-Hui Li, Hui-Dong Tang, Sheng-Di Chen
OBJECTIVES: To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai. METHODS: Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215261/rem-sleep-behavior-disorder-causing-subdural-hematoma
#18
Oscar Ramos-Campoy, Carles Gaig, Monica Villas, Alex Iranzo, Joan Santamaria
No abstract text is available yet for this article.
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28201721/diagnostic-value-of-isolated-mentalis-versus-mentalis-plus-upper-limb-electromyography-in-idiopathic-rem-sleep-behavior-disorder-patients-eventually-developing-a-neurodegenerative-syndrome
#19
Ana Fernández-Arcos, Alex Iranzo, Mónica Serradell, Carles Gaig, Marc Guaita, Manel Salamero, Joan Santamaria
No abstract text is available yet for this article.
February 13, 2017: Sleep
https://www.readbyqxmd.com/read/28163603/rem-sleep-behavior-disorder-rbd-update-on-diagnosis-and-treatment
#20
Birgit Högl, Ambra Stefani
BACKGROUND: REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated. OBJECTIVE: In this review article, the current knowledge regarding RBD diagnosis and treatment is presented. METHODS: A selective literature search was carried out. RESULTS AND DISCUSSION: Although several RBD screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography...
2017: Somnologie: Schlafforschung und Schlafmedizin, Somnology: Sleep Research and Sleep Medicine
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