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Zn and diabete

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https://www.readbyqxmd.com/read/28928060/rosemary-rosmarinus-officinalis-essential-oil-components-exhibit-anti-hyperglycemic-anti-hyperlipidemic-and-antioxidant-effects-in-experimental-diabetes
#1
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
INTRODUCTION: The present study aims to investigate the protective effects of Rosemary (Rosmarinus officinalis L.) essential oils (ROEO) against alloxan-induced diabetes and oxidative stress in rats. METHODS: The animals were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy+ROEO (H+ROEO) and Diabetic+ROEO (D+ROEO). RESULTS: The use of GC/MS technique has allowed us to identify fifteen compounds in ROEO. We have found that alloxan administration induced hyperglycaemia, lipid metabolic parameters deregulation as well as liver and kidney dysfunctions...
September 14, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28916379/carboxymethyl-fenugreek-galactomannan-gellan-gum-calcium-silicate-composite-beads-for-glimepiride-delivery
#2
Hriday Bera, Srilatha Mothe, Sabyasachi Maiti, Sridhar Vanga
Novel carboxymethyl fenugreek galactomannan (CFG)-gellan gum (GG)-calcium silicate (CS) composite beads were developed for controlled glimepiride (GLI) delivery. CFG having degree of carboxymethylation of 0.71 was synthesized and characterized by FTIR, DSC and XRD analyses. Subsequently, GLI-loaded hybrids were accomplished by ionotropic gelation technique employing Ca(+2)/Zn(+2)/Al(+3) ions as cross-linkers. All the formulations demonstrated excellent drug encapsulation efficiency (DEE, 48-97%) and sustained drug release behaviour (Q8h, 62-94%)...
September 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28884459/the-study-on-the-correlation-between-six-kinds-of-mineral-elements-and-diabetes
#3
Zhuo Li, Changcong Wang, Lu Li, Mengyun Shao, Linbo Wang, Xin Lv, Chunshi Gao, Huikun Niu, Bo Li
The study aimed to explore the relationship of six kinds of mineral elements and diabetes among adults in northeast China. A cross-sectional survey was conducted in Jilin Province, northeast China. A total of 366 males and 204 females aged 18 ~ 77 years from Jingyu town, Dongliao town, and Changling town were included using a multistage stratified random cluster sampling design. Data was obtained from face to face interview, physical examination, and laboratory measurement. We defined the normal people (3...
September 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28861360/metalloproteinases-as-mediators-of-inflammation-and-the-eyes-molecular-genetic-underpinnings-governing-ocular-pathophysiology
#4
REVIEW
Mahavir Singh, Suresh C Tyagi
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases (TIMPs) towards maintaining overall homeostasis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28765513/high-glucose-induced-ros-activates-trpm2-to-trigger-lysosomal-membrane-permeabilization-and-zn-2-mediated-mitochondrial-fission
#5
Nada Abuarab, Tim S Munsey, Lin-Hua Jiang, Jing Li, Asipu Sivaprasadarao
Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress-induced mitochondrial fragmentation. We found that chemical inhibitors, RNAi silencing, and genetic knockout of TRPM2 channels abolished the ability of high glucose to cause mitochondrial fission in endothelial cells, a cell type that is particularly vulnerable to diabetic stress. Similar to high glucose, increasing ROS in endothelial cells by applying H2O2 induced mitochondrial fission...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28753206/trpm2-mediated-rise-in-mitochondrial-zn-2-promotes-palmitate-induced-mitochondrial-fission-and-pancreatic-%C3%AE-cell-death-in-rodents
#6
Fangfang Li, Tim S Munsey, Asipu Sivaprasadarao
Rise in plasma free fatty acids (FFAs) represents a major risk factor for obesity-induced type 2 diabetes. Saturated FFAs cause a progressive decline in insulin secretion by promoting pancreatic β-cell death through increased production of reactive oxygen species (ROS). Recent studies have demonstrated that palmitate (a C16-FFA)-induced rise in ROS causes β-cell death by triggering mitochondrial fragmentation, but the underlying mechanisms are unclear. Using the INS1-832/13 β-cell line, here we demonstrate that palmitate generates the ROS required for mitochondrial fission by activating NOX (NADPH oxidase)-2...
July 28, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28693571/characterization-of-erythrose-reductase-from-yarrowia-lipolytica-and-its-influence-on-erythritol-synthesis
#7
Tomasz Janek, Adam Dobrowolski, Anna Biegalska, Aleksandra M Mirończuk
BACKGROUND: Erythritol is a natural sweetener that is used in the food industry. It is produced as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not change the insulin level in the blood, and therefore it can be safely used by diabetics. Previously, it has been shown that erythrose reductase (ER), which catalyzes the final step, plays a crucial role in erythritol synthesis. ER reduces erythrose to erythritol with NAD(P)H as a cofactor. Despite many studies on erythritol synthesis by Yarrowia lipolytica, the enzymes involved in this metabolic pathway have ever been described...
July 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28687933/cellular-zinc-homeostasis-modulates-polarization-of-thp-1-derived-macrophages
#8
Laura Dierichs, Veronika Kloubert, Lothar Rink
PURPOSE: Polarization of macrophages by environmental stimuli leads to the characteristic of different phenotypes that exhibit distinct functions, ranging in a continuous spectrum from pro-inflammatory M1 up to immunoregulatory and wound-healing M2 macrophages. Diseases like cancer, allergic asthma or diabetes are associated with an M1/M2 imbalance. Owing to the importance of the essential trace element zinc for the immune system and its involvement in signal transduction as a second messenger, we investigated the impact of zinc on M1 and M2 polarization of macrophages in vitro...
July 7, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28672144/zn-ii-pramlintide-stability-binding-sites-and-unexpected-aggregation
#9
D Łoboda, M Rowińska-Żyrek
Pramlintide is an antidiabetic drug which mimics amylin - a small peptide co-secreted from pancreatic β-cells together with insulin, one of the hallmarks of type 2 diabetes. In the course of the disease, amylin misfolds into small oligomers or to an aggregated β-sheet amyloid fiber. The misfolding mechanism is not yet quite understood, but it is clear that zinc ions play an important role in the process. This work sheds new light on the role of zinc and pramlintide in the course of the disease, giving a detailed description of the Zn(II)-pramlintide complex, in which the metal ion binds to the imidazole of His18 and the amine group of Lys1, imposing a bend in the peptide between these residues...
September 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28629083/effects-on-insulin-adsorption-due-to-zinc-and-strontium-substitution-in-hydroxyapatite
#10
Luisa A Scudeller, Elena Mavropoulos, Marcelo N Tanaka, Andrea M Costa, Carolina A C Braga, Elvis O López, Alexandre Mello, Alexandre M Rossi
Insulin-loaded calcium phosphate nanoparticles have been proposed as a potential drug delivery system for the oral treatment of diabetes and to stimulate bone cell proliferation and bone mineralization. The kinetics of insulin incorporation onto hydroxyapatite (HA) and Sr (SrHA)- and Zn (ZnHA)-substituted hydroxyapatite nanoparticles was investigated using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, zeta potential measurements and circular dichroism (CD) spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28618722/antioxidants-status-in-type-2-diabetic-patients-in-morocco
#11
Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi
BACKGROUND/AIM: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. MATERIALS AND METHODS: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28595785/comparative-study-of-cardio-protective-effects-of-zinc-oxide-nanoparticles-and-zinc-sulfate-in-streptozotocin-induced-diabetic-rats
#12
Siamak Asri-Rezaei, Bahram Dalir-Naghadeh, Ali Nazarizadeh, Zahra Noori-Sabzikar
The cardio-protective effects of zinc oxide nanoparticles (Zn NPs) against diabetes-induced cardiopathy were evaluated and compared with zinc sulfate (ZnSO4). A total of 120 Wistar rats were randomly categorized as healthy and diabetic groups. Then, the 2 groups were classified in 5 subgroups. The animals received oral supplementations containing different Zn NP (ie, doses of 1, 3, and 10mg/kg) and ZnSO4 (30mg/kg) concentrations over 8 weeks. Blood and cardiac tissue samples were collected in the different time intervals and subjected to biochemical and histopathological analysis...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28592518/zinc-supplementation-does-not-alter-indicators-of-insulin-secretion-and-sensitivity-in-black-and-white-female-adolescents
#13
RANDOMIZED CONTROLLED TRIAL
Andrea J Lobene, Joseph M Kindler, Nathan T Jenkins, Norman K Pollock, Emma M Laing, Arthur Grider, Richard D Lewis
Background: Zinc is a micronutrient involved in the production of, and peripheral sensitivity to, pancreatic β cell-derived insulin. To our knowledge, the effect of zinc supplementation on insulin outcomes, and potential risk of diabetes, in otherwise healthy children in the United States has not been investigated.Objective: The objective of this study was to determine the influence of zinc supplementation on insulin outcomes in black and white girls in the early stages of adolescence. A secondary objective was to determine relations between baseline zinc concentrations and insulin outcomes...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28584737/study-of-lipid-peroxidation-nitric-oxide-end-product-and-trace-element-status-in-type-2-diabetes-mellitus-with-and-without-complications
#14
Sanjukta Mishra, Bana Bihari Mishra
BACKGROUND: Oxidative stress has become a real entity in etiopathogenesis of Type 2 diabetes mellitus (DM). It may result from steady flux of free radicals and lipid peroxides in vivo. Malondialdehyde (MDA) is a stable end product of lipid peroxidation. Accumulative evidences suggest that hyperglycemia in Type 2 DM can produce major changes in nitric oxide (NO) production as well as in its action. Alteration in metabolism of trace elements is also observed in DM. OBJECTIVE: To evaluate oxidative stress, status of NO, and trace elements zinc (Zn) and magnesium (Mg) in type 2 DM and to correlate these parameters with disease process...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28566847/evaluation-of-micronutrient-zinc-magnesium-and-copper-levels-in-serum-and-glycemic-status-after-nonsurgical-periodontal-therapy-in-type-2-diabetic-patients-with-chronic-periodontitis
#15
Gopalakrishnan Sundaram, T Ramakrishnan, Harinath Parthasarathy, Joyson Moses, T Lalitha
AIMS AND OBJECTIVES: To find out the effect of nonsurgical periodontal therapy on serum zinc (Zn), magnesium (Mg), and copper (Cu) concentration and glycemic status in type 2 diabetes with chronic periodontitis (CP). MATERIALS AND METHODS: One hundred and twenty patients were included in this study, which was further divided into three groups. Group 1 consisted of forty patients with CP, Group 2 consisted of forty patients of CP with controlled diabetes, and Group 3 consisted of forty patients of CP with uncontrolled diabetes...
January 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28527712/insulin-fibrillation-the-influence-and-coordination-of-zn-2
#16
Christian Grundahl Frankær, Pernille Sønderby, Maria Blanner Bang, Ramona Valentina Mateiu, Minna Groenning, Jens Bukrinski, Pernille Harris
Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer's disease, diabetes mellitus type 2, or Parkinson's disease. The influence of metal ions on the fibrillation process and whether it is implemented in the amyloid fibrils has been debated for some years. We have therefore investigated the influence and binding geometry of zinc in fibrillated insulin using extended X-ray absorption fine-structure and X-ray absorption near-edge structure spectroscopy...
May 18, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28492302/metal-organic-framework-templated-catalysts-dual-sensitization-of-pdo-zno-composite-on-hollow-sno2-nanotubes-for-selective-acetone-sensors
#17
Won-Tae Koo, Ji-Soo Jang, Seon-Jin Choi, Hee-Jin Cho, Il-Doo Kim
Metal-organic framework (MOF)-derived synergistic catalysts were easily functionalized on hollow SnO2 nanotubes (NTs) via electrospinning and subsequent calcination. Nanoscale Pd NPs (∼2 nm) loaded Zn-based zeolite imidazole framework (Pd@ZIF-8, ∼80 nm) was used as a new catalyst-loading platform for the effective functionalization of a PdO@ZnO complex catalyst onto the thin wall of one-dimensional metal oxide NTs. The well-dispersed nanoscale PdO catalysts (3-4 nm) and multiheterojunctions (PdO/ZnO and ZnO/SnO2) on hollow structures are essential for the development of high-performance gas sensors...
May 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28473060/zinc-supplementation-reduces-rankl-opg-ratio-and-prevents-bone-architecture-alterations-in-ovariectomized-and-type-1-diabetic-rats
#18
Elaine C S Ferreira, Raul H Bortolin, Francisco P Freire-Neto, Karla S C Souza, João F Bezerra, Marcela A G Ururahy, Ana M O Ramos, Silvia T Himelfarb, Bento J Abreu, Thiago V N Didone, Lucia F C Pedrosa, Aldo C Medeiros, Sonia Q Doi, José Brandão-Neto, Rosário D C Hirata, Luciana A Rezende, Maria G Almeida, Mario H Hirata, Adriana A Rezende
Type 1 diabetes mellitus (T1DM) and estrogen deficiency are associated with several alterations in bone turnover. Zinc (Zn) is required for growth, development, and overall health. Zinc has been used in complementary therapy against bone loss in several diseases. We hypothesized that Zn supplementation represents a potential therapy against severe bone loss induced by the combined effect of estrogen deficiency and T1DM. We evaluated the protective effect of Zn against bone alterations in a chronic model of these disorders...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28409409/hypoglycemic-and-hypolipidemic-effects-of-leucine-zinc-and-chromium-alone-and-in-combination-in-rats-with-type-2-diabetes
#19
Hassan Sadri, Negar Nowroozi Larki, Saeed Kolahian
For the increasing development of diabetes, dietary habits and using appropriate supplements can play important roles in the treatment or reduction of risk for this disease. The objective of this study was to investigate the effects of leucine (Leu), zinc (Zn), and chromium (Cr) supplementation, alone or in combination, in rats with type 2 diabetes (T2D). Seventy-seven adult male Wistar rats were randomly assigned in 11 groups, using nutritional supplements and insulin (INS) or glibenclamide (GLC). Supplementing Leu significantly reduced blood glucose, triglycerides (TG), nonesterified fatty acids (NEFA), low-density lipoprotein (LDL), and increased high-density lipoprotein (HDL) concentrations compared to vehicle-treated T2D animals, and those improvements were associated with reduced area under the 2-h blood glucose response curve (AUC)...
April 13, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28401081/zinc-in-pancreatic-islet-biology-insulin-sensitivity-and-diabetes
#20
REVIEW
Wolfgang Maret
About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes...
March 2017: Preventive Nutrition and Food Science
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