keyword
MENU ▼
Read by QxMD icon Read
search

Zn and diabete

keyword
https://www.readbyqxmd.com/read/29322001/evaluation-of-the-antidiabetic-property-of-aqueous-leaves-extract-of%C3%A2-zanthoxylum-armatum-dc-using-in%C3%A2-vivo-and-in%C3%A2-vitro-approaches
#1
Carey Vana Rynjah, Ningthoujam Neelima Devi, Nasheman Khongthaw, Donkupar Syiem, Suktilang Majaw
The present study was designed to evaluate the antidiabetic potential of the aqueous leaves extract of Zanthoxylum armatum DC. leaves using in vivo and in vitro approaches. For in vivo studies, blood glucose level was monitored at different intervals after administration of varying doses of the extract for its hypoglycemic (100-6000 mg/kg b.w.) and antihyperglycemic (250 mg/kg b.w.) effect in normoglycemic and diabetic mice. In vitro enzymatic inhibition activity was tested against α-amylase, α- and β-glucosidase and lipase...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319901/gomisin-a-modulates-aging-progress-via-mitochondrial-biogenesis-in-human-diploid-fibroblast-cells
#2
Jeong-Seok Kim, Seon-Hwa Jeong, Sin-Hee Han, Ho-Keun Yi
Gomisin A from the fruit of Schisandra chinensis has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative stress. However, the potential benefit of gomisin A is still not well understood, especially in aging progression. Therefore, the aim of this study was to clarify whether the promotion of mitochondrial biogenesis and autophagy of gomisin A affects anti-aging progression, and its mechanism. Intermediate (PD32) Human diploid fibroblast (HDF) cells were brought to stress-induced premature senescence (SIPS) using hydrogen peroxide (H2 O2 )...
January 10, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29215553/anti-diabetic-effect-of-organo-chalcogen-sulfur-and-selenium-zinc-complexes-with-hydroxy-pyrone-derivatives-on-leptin-deficient-type-2-diabetes-model-ob-ob-mice
#3
Takayuki Nishiguchi, Yutaka Yoshikawa, Hiroyuki Yasui
Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Zn complexes elicit strong anti-diabetic effects. In this study, we treated leptin-deficient ob/ob mice with organo-chalcogen Zn complexes, and evaluated the resulting anti-diabetic effects in a mouse model of diabetes arising from pathogenic mechanisms different from those in KKAy mice...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29169989/adamts18-deficiency-leads-to-visceral-adiposity-and-associated-metabolic-syndrome-in-mice
#4
Rui Zhu, Mengting Cheng, Tiantian Lu, Ning Yang, Shuai Ye, Yi-Hsuan Pan, Tao Hong, Suying Dang, Wei Zhang
Visceral adiposity is of greater risk than obesity in subcutaneous adipose tissue for diabetes and cardiovascular disease. Its pathogenesis remains unclear, but it is associated with extracellular matrix (ECM) remodeling. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are a family of secreted Zn-dependent metalloproteinases that play crucial roles in development and various diseases owing to their ECM remodeling activity. ADAMTS18 is an "orphan ADAMTS" whose function and substrate remain unclear...
November 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137144/impact-of-labile-zinc-on-heart-function-from-physiology-to-pathophysiology
#5
REVIEW
Belma Turan, Erkan Tuncay
Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn(2+). Although Zn(2+) concentration is in the nM range in cardiomyocytes at rest and increases dramatically under stimulation, very little is known about precise mechanisms controlling the intracellular distribution of Zn(2+) and its variations during cardiac function. Recent studies are focused on molecular and cellular aspects of labile Zn(2+) and its homeostasis in mammalian cells and growing evidence clarified the molecular mechanisms underlying Zn(2+)-diverse functions in the heart, leading to the discovery of novel physiological functions of labile Zn(2+) in parallel to the discovery of subcellular localization of Zn(2+)-transporters in cardiomyocytes...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29102937/beneficial-effect-of-bis-hinokitiolato-zn-complex-on-high-fat-diet-induced-lipid-accumulation-in-mouse-liver-and-kidney
#6
Yuki Naito, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Akiko Takenouchi, Hiroyuki Yasui
BACKGROUND/AIM: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato)Zn, [Zn(hkt)2] on lipid metabolism in the liver and kidney, histopathologically. MATERIALS AND METHODS: We used a high-fat diet (HFD)-fed C57BL/6J mouse model and administered a diet containing 10-20 mg Zn/kg body weight (BW) or 20 mg pioglitazone/kg BW as the positive control...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29079702/metallothionein-preserves-akt2-activity-and-cardiac-function-via-inhibiting-trb3-in-diabetic-hearts
#7
Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild type (WT) male FVB mice, which was accompanied by attenuation of Akt downstream glucose metabolic signal; All these signal changes were not observed in metallothionein cardiac-specific transgenic (MT-TG) hearts. Furthermore, insulin-induced glucose metabolic signals were attenuated only in WT diabetic hearts...
October 27, 2017: Diabetes
https://www.readbyqxmd.com/read/29073545/in-vitro-structure-specific-zn-ii-induced-adipogenesis-and-structure-function-bioreactivity-correlations
#8
E Halevas, O Tsave, M Yavropoulou, J G Yovos, A Hatzidimitriou, V Psycharis, A Salifoglou
The advent of Zn(II) metallodrugs in metabolic syndrome pathologies generates a strong challenge toward synthetic endeavors targeting well-defined, atoxic and biologically active binary/ternary species of Zn(II). Proper formulation of that metal ion's coordination sphere sets the stage for construction of appropriately configured Schiff ligands based on tromethamine and variably modified vanillin core components. The arising Schiff ligands react with Zn(II) in a defined stoichiometry, thereby delivering new binary Zn(II)-L species with defined physicochemical properties...
September 6, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29058176/demonstration-of-subcellular-migration-of-ck2%C3%AE-localization-from-nucleus-to-sarco-endo-plasmic-reticulum-in-mammalian-cardiomyocytes-under-hyperglycemia
#9
Ceylan Verda Bitirim, Erkan Tuncay, Belma Turan
The cellular control of glucose uptake and glycogen metabolism in mammalian tissues is in part mediated through the regulation of protein-serine/threonine kinases including CK2. Although it participates to several cellular signaling processes, however, its subcellular localization is not well-defined while some documents mentioned its localization change under pathological conditions. The activation/phosphorylation of some proteins including Zn(2+)-transporter ZIP7 in cardiomyocytes is controlled with CK2α, thereby, inducing changes in the level of intracellular free Zn(2+) ([Zn(2+)] i )...
October 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29029608/association-of-trace-metal-elements-with-lipid-profiles-in-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#10
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients. METHODS: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis...
October 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29021094/socio-demographic-lifestyle-and-dietary-determinants-of-essential-and-possibly-essential-trace-element-levels-in-adipose-tissue-from-an-adult-cohort
#11
Celia Rodríguez-Pérez, Petra Vrhovnik, Beatriz González-Alzaga, Mariana F Fernández, Piedad Martin-Olmedo, Nicolás Olea, Željka Fiket, Goran Kniewald, Juan P Arrebola
There is increasing evidence linking levels of trace elements (TEs) in adipose tissue with certain chronic conditions (e.g., diabetes or obesity). The objectives of this study were to assess concentrations of a selection of nine essential and possibly-essential TEs in adipose tissue samples from an adult cohort and to explore their socio-demographic, dietary, and lifestyle determinants. Adipose tissue samples were intraoperatively collected from 226 volunteers recruited in two public hospitals from Granada province...
October 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28965568/association-of-reduced-zinc-status-with-poor-glycemic-control-in-individuals-with-type-2-diabetes-mellitus
#12
Verônica da Silva Bandeira, Liliane Viana Pires, Leila Leiko Hashimoto, Luciane Luca de Alencar, Kaluce Gonçalves Sousa Almondes, Simão Augusto Lottenberg, Silvia Maria Franciscato Cozzolino
This study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry method. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were determined...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28965566/differential-cytolocation-and-functional-assays-of-the-two-major-human-slc30a8-znt8-isoforms
#13
Sandra Carvalho, Jorge Molina-López, Douglas Parsons, Christopher Corpe, Wolfgang Maret, Christer Hogstrand
The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D). Although the molecular details remain unknown, the mutation is thought to alter the kinetics of zinc transport into insulin granules in pancreatic β-cells. Nevertheless, analysis of ZnT8 sequences from several animals shows that the amino acid at position 325 is poorly conserved. Apart from this particular SNP, human ZnT8 also has two isoforms (splice variants) that differ in length regarding a 49 amino acid N-terminal extension...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28928060/rosemary-rosmarinus-officinalis-essential-oil-components-exhibit-anti-hyperglycemic-anti-hyperlipidemic-and-antioxidant-effects-in-experimental-diabetes
#14
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
INTRODUCTION: The present study aims to investigate the protective effects of Rosemary (Rosmarinus officinalis L.) essential oils (ROEO) against alloxan-induced diabetes and oxidative stress in rats. METHODS: The animals were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy+ROEO (H+ROEO) and Diabetic+ROEO (D+ROEO). RESULTS: The use of GC/MS technique has allowed us to identify fifteen compounds in ROEO. We have found that alloxan administration induced hyperglycaemia, lipid metabolic parameters deregulation as well as liver and kidney dysfunctions...
September 14, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28916379/carboxymethyl-fenugreek-galactomannan-gellan-gum-calcium-silicate-composite-beads-for-glimepiride-delivery
#15
Hriday Bera, Srilatha Mothe, Sabyasachi Maiti, Sridhar Vanga
Novel carboxymethyl fenugreek galactomannan (CFG)-gellan gum (GG)-calcium silicate (CS) composite beads were developed for controlled glimepiride (GLI) delivery. CFG having degree of carboxymethylation of 0.71 was synthesized and characterized by FTIR, DSC and XRD analyses. Subsequently, GLI-loaded hybrids were accomplished by ionotropic gelation technique employing Ca(+2)/Zn(+2)/Al(+3) ions as cross-linkers. All the formulations demonstrated excellent drug encapsulation efficiency (DEE, 48-97%) and sustained drug release behaviour (Q8h, 62-94%)...
September 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28884459/the-study-on-the-correlation-between-six-kinds-of-mineral-elements-and-diabetes
#16
Zhuo Li, Changcong Wang, Lu Li, Mengyun Shao, Linbo Wang, Xin Lv, Chunshi Gao, Huikun Niu, Bo Li
The study aimed to explore the relationship of six kinds of mineral elements and diabetes among adults in northeast China. A cross-sectional survey was conducted in Jilin Province, northeast China. A total of 366 males and 204 females aged 18 ~ 77 years from Jingyu town, Dongliao town, and Changling town were included using a multistage stratified random cluster sampling design. Data was obtained from face to face interview, physical examination, and laboratory measurement. We defined the normal people (3...
September 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28861360/metalloproteinases-as-mediators-of-inflammation-and-the-eyes-molecular-genetic-underpinnings-governing-ocular-pathophysiology
#17
REVIEW
Mahavir Singh, Suresh C Tyagi
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases (TIMPs) towards maintaining overall homeostasis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28765513/high-glucose-induced-ros-activates-trpm2-to-trigger-lysosomal-membrane-permeabilization-and-zn-2-mediated-mitochondrial-fission
#18
Nada Abuarab, Tim S Munsey, Lin-Hua Jiang, Jing Li, Asipu Sivaprasadarao
Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress-induced mitochondrial fragmentation. We found that chemical inhibitors, RNAi silencing, and genetic knockout of TRPM2 channels abolished the ability of high glucose to cause mitochondrial fission in endothelial cells, a cell type that is particularly vulnerable to diabetic stress. Similar to high glucose, increasing ROS in endothelial cells by applying H2O2 induced mitochondrial fission...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28753206/trpm2-mediated-rise-in-mitochondrial-zn-2-promotes-palmitate-induced-mitochondrial-fission-and-pancreatic-%C3%AE-cell-death-in-rodents
#19
Fangfang Li, Tim S Munsey, Asipu Sivaprasadarao
Rise in plasma free fatty acids (FFAs) represents a major risk factor for obesity-induced type 2 diabetes. Saturated FFAs cause a progressive decline in insulin secretion by promoting pancreatic β-cell death through increased production of reactive oxygen species (ROS). Recent studies have demonstrated that palmitate (a C16-FFA)-induced rise in ROS causes β-cell death by triggering mitochondrial fragmentation, but the underlying mechanisms are unclear. Using the INS1-832/13 β-cell line, here we demonstrate that palmitate generates the ROS required for mitochondrial fission by activating NOX (NADPH oxidase)-2...
December 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28693571/characterization-of-erythrose-reductase-from-yarrowia-lipolytica-and-its-influence-on-erythritol-synthesis
#20
Tomasz Janek, Adam Dobrowolski, Anna Biegalska, Aleksandra M Mirończuk
BACKGROUND: Erythritol is a natural sweetener that is used in the food industry. It is produced as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not change the insulin level in the blood, and therefore it can be safely used by diabetics. Previously, it has been shown that erythrose reductase (ER), which catalyzes the final step, plays a crucial role in erythritol synthesis. ER reduces erythrose to erythritol with NAD(P)H as a cofactor. Despite many studies on erythritol synthesis by Yarrowia lipolytica, the enzymes involved in this metabolic pathway have ever been described...
July 11, 2017: Microbial Cell Factories
keyword
keyword
48328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"