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Zn and diabete

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https://www.readbyqxmd.com/read/28302075/renal-effects-of-metallothionein-induction-by-zinc-in-vitro-and-in-vivo
#1
Moritz Schanz, Lea Schaaf, Juergen Dippon, Dagmar Biegger, Peter Fritz, Mark Dominik Alscher, Martin Kimmel
BACKGROUND: Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative protective role in diabetes and hypoxia. Our goal was to further investigate the behavior of MTT under the influence of Zn and hypoxia in vitro and in vivo. METHODS: MTT expression was measured in vitro in cell cultures of proximal tubular cells (LCC-PK1) by immune-histochemistry and real-time PCR after incubation with increasing concentrations of Zn under hypoxic and non-hypoxic conditions...
March 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28281224/the-effects-of-supplementary-cr3-chromium-iii-propionate-complex-on-the-mineral-status-in-healthy-female-rats
#2
Halina Staniek, Zbigniew Krejpcio
More and more people use food supplements for various reasons, e.g. to prevent mineral deficiency and diseases (e.g. osteoporosis, diabetes, anaemia). Supplements containing Cr(III) are purchased primarily for weight loss and antidiabetic effects. The aim of this study was to evaluate the effects of supplementary Cr3 {chromium(III) propionate complex, [Cr3O(O2CCH2CH3)6(H2O)3]NO3)} on the mineral status in female Wistar rats. The study was carried out on 30 female Wistar rats, divided into five groups (six animals in each): a control group and test groups fed Cr3 supplemented diets with 100, 200, 500 and 1000 mg Cr · kg(-1) diet (equivalent to 10, 20, 50 and 100 mg Cr ·kg(-1) body mass (b...
March 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28276155/dissecting-copper-homeostasis-in-diabetes-mellitus
#3
REVIEW
Jennifer Lowe, Rosilane Taveira-da-Silva, Elaine Hilário-Souza
Diabetes Mellitus (DM) is characterized by elevated blood glucose levels (hyperglycemia). It can occur due to impaired secretion or action of the hormone insulin, which is produced by pancreatic beta-cells to promote the entry of glucose into the cells. It is known that hyperglycemia has an important role in the production of reactive oxygen species in all types of DM and that an imbalance of transition metal as Cu and Fe plays a pivotal role in stimulating the oxidative stress. Different levels of some transition metals, as Cu, Fe, Mn, and Zn has been reported comparing diabetic animal models with the control group...
March 9, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28258359/concentration-of-zinc-copper-iron-calcium-and-magnesium-in-the-serum-tissues-and-urine-of-streptozotocin-induced-mild-diabetic-rat-model
#4
Tahiry Gómez, Leticia Bequer, Angel Mollineda, José L Molina, Alain Álvarez, Mayrelis Lavastida, Sonia Clapés
The present study aimed to investigate, in the streptozotocin-induced mild diabetic rat model, the zinc (Zn), copper (Cu), iron (Fe), calcium (Ca), and magnesium (Mg) concentration in serum, liver, and kidney tissues, and urine samples from adult Wistar rats treated neonatally with streptozotocin (STZ). Diabetes was induced by subcutaneous administration of streptozotocin (100 mg/Kg) in female Wistar rats of 2 days old (STZ, n = 10). Control group (CG, n = 10) received only sodium-citrate buffer. The mineral concentrations were measured by atomic absorption spectrophotometry...
March 3, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28250273/anti-hyperglycemic-effect-of-long-term-bis-hinokitiolato-zinc-complex-zn-hkt-2-ingestion-on-insulin-resistance-and-pancreatic-islet-cells-protection-in-type-2-diabetic-kk-a-y-mice
#5
Yuki Naito, Yutaka Yoshikawa, Michiko Shintani, Shingo Kamoshida, Naemi Kajiwara, Hiroyuki Yasui
Zinc (Zn) is a trace element with anti-diabetes mellitus (anti-DM) effects. Zn complexes exhibit stronger insulin-like activity than Zn ions. Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) was recently reported to be a potent anti-DM candidate. We examined the effects of [Zn(hkt)2] on insulin resistance and pancreatic islet cells through in vivo long-term ingestion studies. In an in vivo study, we performed 4-month long-term [Zn(hkt)2] administration experiments in KK-A(y) mice as a type 2 DM animal model. Ingestion of [Zn(hkt)2] resulted in lower blood glucose levels compared with the non-treated KK-A(y) mice (control group)...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28245884/attenuation-of-oxidative-stress-and-cardioprotective-effects-of-zinc-supplementation-in-experimental-diabetic-rats
#6
Susmita Barman, Krishnapura Srinivasan
Oxidative stress plays a major role in the pathogenesis of diabetes mellitus, which further exacerbates damage of cardiac, hepatic and other tissues. We have recently reported that Zn supplementation beneficially modulates hyperglycaemia and hypoinsulinaemia, with attendant reduction of associated metabolic abnormalities in diabetic rats. The present study assessed the potential of Zn supplementation in modulating oxidative stress and cardioprotective effects in diabetic rats. Diabetes was induced in Wistar rats with streptozotocin, and groups of diabetic rats were treated with 5- and 10-fold dietary Zn interventions (0·19 and 0·38 g Zn/kg diet) for 6 weeks...
March 1, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/27908424/first-comprehensive-study-on-total-contents-and-hot-water-extractable-fraction-of-selected-elements-in-19-medicinal-plants-from-various-locations-in-nyamira-county-kenya
#7
Volker Nischwitz, Richard Mogwasi, Salim Zor, Zachary Getenga, David K Kariuki, Klaus Günther
A large number of medicinal plants is traditionally known in Kenya and used for treatment of various diseases, for example diabetes, where metals are supposed to be involved in pathogenesis and therapy. Therefore, detailed investigation of the concentration of a large number of metals in medicinal plants is required for improved understanding and optimisation of the therapeutic role of metals and also to exclude potentially toxic effects. Our study focused on the determination of 30 selected elements in 19 medicinal plant species each collected from 3 sampling locations in Nyamira County, Kenya...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908401/the-variation-of-macro-and-micro-minerals-of-tissues-in-diabetic-and-non-diabetic-rats
#8
Tennille D Presley, A'ja V Duncan, Anne B Jeffers, Sayo O Fakayode
This study determined the levels of Ca, Mg, Fe, Zn, Cu, and Na in various tissues samples (liver, brain, kidney, intestines, muscle and hair) of diabetic and non-diabetic rats by flame atomic absorption spectroscopy, in order to assess the role of element levels during T2DM. The ratios of Ca/Mg, Zn/Cu, Ca/Zn, and Mg/Zn in diabetic and non-diabetic rat tissues were also calculated. The determined element levels were further subjected to a student-t test statistical analysis and multiple-linear-regression in order to evaluate similarities, differences, and an inter-element association in tissues of diabetic and non-diabetic rats...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27899481/hznt8-slc30a8-transgenic-mice-that-overexpress-the-r325w-polymorph-have-reduced-islet-zn2-and-proinsulin-levels-increased-glucose-tolerance-after-a-high-fat-diet-and-altered-levels-of-pancreatic-zinc-binding-proteins
#9
Li Li, Shi Bai, Christian T Sheline
Zinc (Zn(2+)) is involved in both type 1 diabetes (T1DM) and type 2 diabetes (T2DM). The wild-type (WT) form of the β-cell-specific Zn(2+) transporter, ZNT8, is linked to T2DM susceptibility. ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM. We measured Zn(2+), insulin, and proinsulin stainings and performed intraperitoneal glucose tolerance testing in transgenic mice overexpressing hZnT8 WT or hZnT8 R325W fed a normal or high-fat diet...
February 2017: Diabetes
https://www.readbyqxmd.com/read/27895622/serum-zn-cu-ratio-is-associated-with-renal-function-glycemic-control-and-metabolic-parameters-in-japanese-patients-with-and-without-type-2-diabetes-a-cross-sectional-study
#10
Hidetaka Hamasaki, Yu Kawashima, Hidekatsu Yanai
BACKGROUND: Zinc (Zn) and copper (Cu) may play a pivotal role in the pathogenesis of diabetes and diabetic complications by mediating oxidative stress. Both Zn deficiency and excess of Cu are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to investigate the relationships between serum Zn/Cu ratio and glycemic status, renal function, and metabolic parameters in patients with and without type 2 diabetes. METHODS: We conducted a cross-sectional study on 355 subjects (149 type 2 diabetic and 206 non-diabetic) in whom serum Zn and Cu levels were measured at the same time...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27890939/the-metal-face-of-protein-tyrosine-phosphatase-1b
#11
REVIEW
Elisa Bellomo, Kshetrimayum Birla Singh, Alberto Massarotti, Christer Hogstrand, Wolfgang Maret
A new paradigm in metallobiochemistry describes the activation of inactive metalloenzymes by metal ion removal. Protein tyrosine phosphatases (PTPs) do not seem to require a metal ion for enzymatic activity. However, both metal cations and metal anions modulate their enzymatic activity. One binding site is the phosphate binding site at the catalytic cysteine residue. Oxyanions with structural similarity to phosphate, such as vanadate, inhibit the enzyme with nanomolar to micromolar affinities. In addition, zinc ions (Zn(2+)) inhibit with picomolar to nanomolar affinities...
November 15, 2016: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/27882813/dietary-zinc-modifies-diabetic-induced-renal-pathology-in-rats
#12
Wael M Elsaed, Hazem Abdelhamid Mohamed
This study was conducted to investigate how far dietary zinc (Zn) modifies the histomorphological alterations induced by diabetes in rat kidneys. The animals were divided into negative control group (10 rats). Diabetes was induced in thirty animals by streptozotocin. After confirming diabetes, the animals were divided into three groups (n = 10). Group II served as the positive control group (fed on standard diet), group III was fed on Zn deficient diet, and group IV was fed on Zn supplemented diet. Caspase-3 immune staining was used to estimate the caspase activity...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27881232/serum-copper-zinc-and-iron-levels-and-markers-of-carbohydrate-metabolism-in-postmenopausal-women-with-prediabetes-and-type-2-diabetes-mellitus
#13
Margarita G Skalnaya, Anatoly V Skalny, Alexey A Tinkov
The objective of the present study was to evaluate serum level of copper, zinc, iron and metabolic parameters in postmenopausal women with diabetes. A total of 413 postmenopausal women were enrolled in the current study. Women were divided into 4 groups with equal age and body mass index according to glycated hemoglobin (HbA1c) levels (≤5.5; 5.5-6.0; 6.0-6.5; >6.5%). Serum Fe, Cu, and Zn levels were assessed using inductively-coupled plasma mass-spectrometry. Blood HbA1c, serum glucose, insulin, C-reactive protein (CRP), ferritin, and ceruloplasmin (Cp) were assessed using commercial kits...
November 16, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27803448/dual-effect-of-curcumin-zinc-complex-in-controlling-diabetes-mellitus-in-experimentally-induced-diabetic-rats
#14
Khalil Al-Ali, Hala Salah Abdel Fatah, Yaser Abdel-Moemen El-Badry
Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27795982/profile-of-trace-elements-in-selected-medicinal-plants-used-for-the-treatment-of-diabetes-in-eritrea
#15
Mussie Sium, Patrick Kareru, Joseph Keriko, Berhane Girmay, Ghebrehiwet Medhanie, Semere Debretsion
This study was designed to investigate the profile of certain trace elements having therapeutic properties related to diabetes mellitus. The investigated plants were Aloe camperi, Meriandra dianthera, Lepidium sativum, Brassica nigra, and Nigella sativa. These plants are traditionally used in the management of diabetes in Eritrea. The elemental analysis was conducted using inductively coupled plasma optical emission spectrometry (ICP-OES) and flame atomic absorption spectroscopy (FAAS) techniques. The accuracy of the methods was verified using in-house reference materials (CRMs) and no significant differences were observed between the measured and certified values...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27761143/altered-concentrations-of-copper-zinc-and-iron-are-associated-with-increased-levels-of-glycated-hemoglobin-in-patients-with-type-2-diabetes-mellitus-and-their-first-degree-relatives
#16
Somayeh Atari-Hajipirloo, Neda Valizadeh, Mohammad-Hassan Khadem-Ansari, Yousef Rasmi, Fatemeh Kheradmand
BACKGROUND: The altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. OBJECTIVES: The aim of the present study was to compare the concentrations of essential trace elements, copper (Cu), zinc (Zn), and iron (Fe) in the serum of patients who have type 2 diabetes mellitus (T2DM) with those of their non-diabetic first-degree relatives (FDR) and control subjects. The association between glycated hemoglobin (HbA1c) and levels of metals was also evaluated...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27752920/serum-trace-elements-and-electrolytes-are-associated-with-fasting-plasma-glucose-and-hba1c-in-postmenopausal-women-with-type-2-diabetes-mellitus
#17
Margarita G Skalnaya, Anatoly V Skalny, Vasily V Yurasov, Vasily A Demidov, Andrei R Grabeklis, Ivan V Radysh, Alexey A Tinkov
The primary aim of the research was to assess the level of trace elements and electrolytes in serum of postmenopausal diabetic women. Sixty-four postmenopausal women with type 2 diabetes mellitus (DM2) and 64 age- and body mass index-matched controls were examined. Serum trace elements were assessed using inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS). Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) levels were evaluated using Randox kits. The obtained data demonstrate that DM2 patients were characterized by 42 and 34 % higher FPG and HbA1c levels, respectively (p < 0...
October 18, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27744600/resveratrol-attenuates-copper-and-zinc-homeostasis-and-ameliorates-oxidative-stress-in-type-2-diabetic-rats
#18
Soheila Asadi, Mohammad Nabi Moradi, Nejat Khyripour, Mohammad Taghi Goodarzi, Marzieh Mahmoodi
Diabetes is a common metabolic disorder characterized by elevated blood glucose level. Trace element homeostasis causes disturbances in diabetes due to hyperglycemia. Superoxide dismutase (SOD), an antioxidant enzyme, contains zinc and copper ions as its cofactors. Defects in SOD level and activity have been observed in diabetes. Resveratrol (RSV) has displayed hypoglycemic effects and is proven to improve oxidative stress. The aim of the present study was to examine the possible effects of RSV on blood glucose level, serum copper and zinc levels, SOD, and a number of other oxidative markers in type 2 diabetic rats...
October 15, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27665301/does-zinc-really-metal-with-diabetes-the-epidemiologic-evidence
#19
Manuel Ruz, Fernando Carrasco, Andrés Sánchez, Alvaro Perez, Pamela Rojas
Zinc (Zn) is important in a number of processes related to insulin secretion and insulin activity in peripheral tissues, making this element an interesting potential co-adjuvant in the treatment of patients with type 2 diabetes (T2D). This issue has been matter of interest in recent years. The available evidence is analyzed in this review. Information from epidemiologic studies evaluating the relationship between Zn and T2D is inconsistent. Furthermore, few studies examined the association between Zn status and insulin action and/or glucose homeostasis...
November 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27609014/investigation-of-lipid-peroxidation-and-antiapoptotic-effects-of-zinc-aganist-liver-damage-in-diabetic-rats
#20
M Tunçdemir, S P Ertürküner, D Özçelik
Several mechanisms for the pathogenesis of diabetic complications have been proposed, one of which is abnormal zinc (Zn) homeostasis. Zn is necessary for proper liver function since it has important antioxidant, anti-inflammatory, and antiapoptotic properties. We aimed to investigate whether or not Zn has morphologically protective effect on diabetes-induced liver damage in rats. In addition, we have investigated the role of Zn supplementation on apoptosis, lipid peroxidation levels, and the distribution of metallothionein (MT) in diabetic liver tissue...
September 7, 2016: Human & Experimental Toxicology
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