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Zn and diabete

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https://www.readbyqxmd.com/read/29137144/impact-of-labile-zinc-on-heart-function-from-physiology-to-pathophysiology
#1
REVIEW
Belma Turan, Erkan Tuncay
Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn(2+). Although Zn(2+) concentration is in the nM range in cardiomyocytes at rest and increases dramatically under stimulation, very little is known about precise mechanisms controlling the intracellular distribution of Zn(2+) and its variations during cardiac function. Recent studies are focused on molecular and cellular aspects of labile Zn(2+) and its homeostasis in mammalian cells and growing evidence clarified the molecular mechanisms underlying Zn(2+)-diverse functions in the heart, leading to the discovery of novel physiological functions of labile Zn(2+) in parallel to the discovery of subcellular localization of Zn(2+)-transporters in cardiomyocytes...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29102937/beneficial-effect-of-bis-hinokitiolato-zn-complex-on-high-fat-diet-induced-lipid-accumulation-in-mouse-liver-and-kidney
#2
Yuki Naito, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Akiko Takenouchi, Hiroyuki Yasui
BACKGROUND/AIM: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato)Zn, [Zn(hkt)2] on lipid metabolism in the liver and kidney, histopathologically. MATERIALS AND METHODS: We used a high-fat diet (HFD)-fed C57BL/6J mouse model and administered a diet containing 10-20 mg Zn/kg body weight (BW) or 20 mg pioglitazone/kg BW as the positive control...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29079702/metallothionein-preserves-akt2-activity-and-cardiac-function-via-inhibiting-trb3-in-diabetic-hearts
#3
Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild type (WT) male FVB mice, which was accompanied by attenuation of Akt downstream glucose metabolic signal; All these signal changes were not observed in metallothionein cardiac-specific transgenic (MT-TG) hearts. Furthermore, insulin-induced glucose metabolic signals were attenuated only in WT diabetic hearts...
October 27, 2017: Diabetes
https://www.readbyqxmd.com/read/29073545/in-vitro-structure-specific-zn-ii-induced-adipogenesis-and-structure-function-bioreactivity-correlations
#4
E Halevas, O Tsave, M Yavropoulou, J G Yovos, A Hatzidimitriou, V Psycharis, A Salifoglou
The advent of Zn(II) metallodrugs in metabolic syndrome pathologies generates a strong challenge toward synthetic endeavors targeting well-defined, atoxic and biologically active binary/ternary species of Zn(II). Proper formulation of that metal ion's coordination sphere sets the stage for construction of appropriately configured Schiff ligands based on tromethamine and variably modified vanillin core components. The arising Schiff ligands react with Zn(II) in a defined stoichiometry, thereby delivering new binary Zn(II)-L species with defined physicochemical properties...
September 6, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29058176/demonstration-of-subcellular-migration-of-ck2%C3%AE-localization-from-nucleus-to-sarco-endo-plasmic-reticulum-in-mammalian-cardiomyocytes-under-hyperglycemia
#5
Ceylan Verda Bitirim, Erkan Tuncay, Belma Turan
The cellular control of glucose uptake and glycogen metabolism in mammalian tissues is in part mediated through the regulation of protein-serine/threonine kinases including CK2. Although it participates to several cellular signaling processes, however, its subcellular localization is not well-defined while some documents mentioned its localization change under pathological conditions. The activation/phosphorylation of some proteins including Zn(2+)-transporter ZIP7 in cardiomyocytes is controlled with CK2α, thereby, inducing changes in the level of intracellular free Zn(2+) ([Zn(2+)] i )...
October 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29029608/association-of-trace-metal-elements-with-lipid-profiles-in-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#6
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients. METHODS: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis...
October 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29021094/socio-demographic-lifestyle-and-dietary-determinants-of-essential-and-possibly-essential-trace-element-levels-in-adipose-tissue-from-an-adult-cohort
#7
Celia Rodríguez-Pérez, Petra Vrhovnik, Beatriz González-Alzaga, Mariana F Fernández, Piedad Martin-Olmedo, Nicolás Olea, Željka Fiket, Goran Kniewald, Juan P Arrebola
There is increasing evidence linking levels of trace elements (TEs) in adipose tissue with certain chronic conditions (e.g., diabetes or obesity). The objectives of this study were to assess concentrations of a selection of nine essential and possibly-essential TEs in adipose tissue samples from an adult cohort and to explore their socio-demographic, dietary, and lifestyle determinants. Adipose tissue samples were intraoperatively collected from 226 volunteers recruited in two public hospitals from Granada province...
October 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28965568/association-of-reduced-zinc-status-with-poor-glycemic-control-in-individuals-with-type-2-diabetes-mellitus
#8
Verônica da Silva Bandeira, Liliane Viana Pires, Leila Leiko Hashimoto, Luciane Luca de Alencar, Kaluce Gonçalves Sousa Almondes, Simão Augusto Lottenberg, Silvia Maria Franciscato Cozzolino
This study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry method. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were determined...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28965566/differential-cytolocation-and-functional-assays-of-the-two-major-human-slc30a8-znt8-isoforms
#9
Sandra Carvalho, Jorge Molina-López, Douglas Parsons, Christopher Corpe, Wolfgang Maret, Christer Hogstrand
The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D). Although the molecular details remain unknown, the mutation is thought to alter the kinetics of zinc transport into insulin granules in pancreatic β-cells. Nevertheless, analysis of ZnT8 sequences from several animals shows that the amino acid at position 325 is poorly conserved. Apart from this particular SNP, human ZnT8 also has two isoforms (splice variants) that differ in length regarding a 49 amino acid N-terminal extension...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28928060/rosemary-rosmarinus-officinalis-essential-oil-components-exhibit-anti-hyperglycemic-anti-hyperlipidemic-and-antioxidant-effects-in-experimental-diabetes
#10
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
INTRODUCTION: The present study aims to investigate the protective effects of Rosemary (Rosmarinus officinalis L.) essential oils (ROEO) against alloxan-induced diabetes and oxidative stress in rats. METHODS: The animals were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy+ROEO (H+ROEO) and Diabetic+ROEO (D+ROEO). RESULTS: The use of GC/MS technique has allowed us to identify fifteen compounds in ROEO. We have found that alloxan administration induced hyperglycaemia, lipid metabolic parameters deregulation as well as liver and kidney dysfunctions...
September 14, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28916379/carboxymethyl-fenugreek-galactomannan-gellan-gum-calcium-silicate-composite-beads-for-glimepiride-delivery
#11
Hriday Bera, Srilatha Mothe, Sabyasachi Maiti, Sridhar Vanga
Novel carboxymethyl fenugreek galactomannan (CFG)-gellan gum (GG)-calcium silicate (CS) composite beads were developed for controlled glimepiride (GLI) delivery. CFG having degree of carboxymethylation of 0.71 was synthesized and characterized by FTIR, DSC and XRD analyses. Subsequently, GLI-loaded hybrids were accomplished by ionotropic gelation technique employing Ca(+2)/Zn(+2)/Al(+3) ions as cross-linkers. All the formulations demonstrated excellent drug encapsulation efficiency (DEE, 48-97%) and sustained drug release behaviour (Q8h, 62-94%)...
September 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28884459/the-study-on-the-correlation-between-six-kinds-of-mineral-elements-and-diabetes
#12
Zhuo Li, Changcong Wang, Lu Li, Mengyun Shao, Linbo Wang, Xin Lv, Chunshi Gao, Huikun Niu, Bo Li
The study aimed to explore the relationship of six kinds of mineral elements and diabetes among adults in northeast China. A cross-sectional survey was conducted in Jilin Province, northeast China. A total of 366 males and 204 females aged 18 ~ 77 years from Jingyu town, Dongliao town, and Changling town were included using a multistage stratified random cluster sampling design. Data was obtained from face to face interview, physical examination, and laboratory measurement. We defined the normal people (3...
September 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28861360/metalloproteinases-as-mediators-of-inflammation-and-the-eyes-molecular-genetic-underpinnings-governing-ocular-pathophysiology
#13
REVIEW
Mahavir Singh, Suresh C Tyagi
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases (TIMPs) towards maintaining overall homeostasis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28765513/high-glucose-induced-ros-activates-trpm2-to-trigger-lysosomal-membrane-permeabilization-and-zn-2-mediated-mitochondrial-fission
#14
Nada Abuarab, Tim S Munsey, Lin-Hua Jiang, Jing Li, Asipu Sivaprasadarao
Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress-induced mitochondrial fragmentation. We found that chemical inhibitors, RNAi silencing, and genetic knockout of TRPM2 channels abolished the ability of high glucose to cause mitochondrial fission in endothelial cells, a cell type that is particularly vulnerable to diabetic stress. Similar to high glucose, increasing ROS in endothelial cells by applying H2O2 induced mitochondrial fission...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28753206/trpm2-mediated-rise-in-mitochondrial-zn-2-promotes-palmitate-induced-mitochondrial-fission-and-pancreatic-%C3%AE-cell-death-in-rodents
#15
Fangfang Li, Tim S Munsey, Asipu Sivaprasadarao
Rise in plasma free fatty acids (FFAs) represents a major risk factor for obesity-induced type 2 diabetes. Saturated FFAs cause a progressive decline in insulin secretion by promoting pancreatic β-cell death through increased production of reactive oxygen species (ROS). Recent studies have demonstrated that palmitate (a C16-FFA)-induced rise in ROS causes β-cell death by triggering mitochondrial fragmentation, but the underlying mechanisms are unclear. Using the INS1-832/13 β-cell line, here we demonstrate that palmitate generates the ROS required for mitochondrial fission by activating NOX (NADPH oxidase)-2...
December 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28693571/characterization-of-erythrose-reductase-from-yarrowia-lipolytica-and-its-influence-on-erythritol-synthesis
#16
Tomasz Janek, Adam Dobrowolski, Anna Biegalska, Aleksandra M Mirończuk
BACKGROUND: Erythritol is a natural sweetener that is used in the food industry. It is produced as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not change the insulin level in the blood, and therefore it can be safely used by diabetics. Previously, it has been shown that erythrose reductase (ER), which catalyzes the final step, plays a crucial role in erythritol synthesis. ER reduces erythrose to erythritol with NAD(P)H as a cofactor. Despite many studies on erythritol synthesis by Yarrowia lipolytica, the enzymes involved in this metabolic pathway have ever been described...
July 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28687933/cellular-zinc-homeostasis-modulates-polarization-of-thp-1-derived-macrophages
#17
Laura Dierichs, Veronika Kloubert, Lothar Rink
PURPOSE: Polarization of macrophages by environmental stimuli leads to the characteristic of different phenotypes that exhibit distinct functions, ranging in a continuous spectrum from pro-inflammatory M1 up to immunoregulatory and wound-healing M2 macrophages. Diseases like cancer, allergic asthma or diabetes are associated with an M1/M2 imbalance. Owing to the importance of the essential trace element zinc for the immune system and its involvement in signal transduction as a second messenger, we investigated the impact of zinc on M1 and M2 polarization of macrophages in vitro...
July 7, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28672144/zn-ii-pramlintide-stability-binding-sites-and-unexpected-aggregation
#18
D Łoboda, M Rowińska-Żyrek
Pramlintide is an antidiabetic drug which mimics amylin - a small peptide co-secreted from pancreatic β-cells together with insulin, one of the hallmarks of type 2 diabetes. In the course of the disease, amylin misfolds into small oligomers or to an aggregated β-sheet amyloid fiber. The misfolding mechanism is not yet quite understood, but it is clear that zinc ions play an important role in the process. This work sheds new light on the role of zinc and pramlintide in the course of the disease, giving a detailed description of the Zn(II)-pramlintide complex, in which the metal ion binds to the imidazole of His18 and the amine group of Lys1, imposing a bend in the peptide between these residues...
September 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28629083/effects-on-insulin-adsorption-due-to-zinc-and-strontium-substitution-in-hydroxyapatite
#19
Luisa A Scudeller, Elena Mavropoulos, Marcelo N Tanaka, Andrea M Costa, Carolina A C Braga, Elvis O López, Alexandre Mello, Alexandre M Rossi
Insulin-loaded calcium phosphate nanoparticles have been proposed as a potential drug delivery system for the oral treatment of diabetes and to stimulate bone cell proliferation and bone mineralization. The kinetics of insulin incorporation onto hydroxyapatite (HA) and Sr (SrHA)- and Zn (ZnHA)-substituted hydroxyapatite nanoparticles was investigated using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, zeta potential measurements and circular dichroism (CD) spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28618722/antioxidants-status-in-type-2-diabetic-patients-in-morocco
#20
Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi
BACKGROUND/AIM: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. MATERIALS AND METHODS: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se)...
June 12, 2017: Turkish Journal of Medical Sciences
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