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Zn and diabete

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https://www.readbyqxmd.com/read/29773198/serum-concentrations-of-trace-elements-and-their-relationships-with-paraoxonase-1-in-morbidly-obese-women
#1
Fedra Luciano-Mateo, Noemí Cabré, Martí Nadal, Anabel García-Heredia, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Jordi Camps, Jorge Joven, José Luis Domingo
The metabolic alterations associated with obesity include mineral dysregulation. Essential trace elements are nutrients with a relevant function in a large number of cellular processes and multiple roles in the correct functioning of metabolic enzymes. Paraoxonase-1 (PON1) is an antioxidant and anti-inflammatory enzyme that is compromised in obesity. In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29763559/long-acting-release-microspheres-containing-novel-glp-1-analog-as-an-antidiabetic-system
#2
Sida Ruan, Yuanyuan Gu, Bo Liu, Huashan Gao, Xiongwei Hu, Haiping Hao, Liang Jin, Ting Cai
Glucagon-like peptide 1 (GLP-1) has recently received significant attention as an efficacious way to treat diabetes mellitus. However, the short half-life of the peptide limits its clinical application in diabetes. In our previous study, a novel GLP-1 analog (PGLP-1) with a longer half-life was synthesized and evaluated. Herein, we prepared the PGLP-1-loaded poly(D,L-lactide-co- glycolide) microspheres to achieve long-term effects on blood glucose control. The incorporation of zinc ion into the formulation can effectively decrease the initial burst release, and a uniform drug distribution was obtained, in contrast to native PGLP-1 encapsulated microspheres...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29736225/molecular-changes-in-obese-and-depressive-patients-are-similar-to-neurodegenerative-disorders
#3
Laleh Habibi, Abbas Tafakhori, Rasoul Hadiani, Maryam Maserat-Mashhadi, Zeinab Kafrash, Shahla Torabi, Mohammad Azhdarzadeh, Seyed Mohammad Akrami, Morteza Mahmoudi, Rasoul Dinarvand
Background: Neurodegenerative disorders (NDs) are categorized as multifactorial conditions with different molecular and environmental causes. Disturbance of important signaling pathways, such as energy metabolism and inflammation induced by environmental agents, is involved in the pathophysiology of NDs. It has been proposed that changes in the lifestyle and nutrition (metabolism) during mid-life could trigger and accumulate cellular and molecular damages resulting in NDs during aging. Methods: In order to test the hypothesis, we investigated the expression level of two energy metabolism-related [forkhead box O1 (FOXO1) and forkhead box O3 (FOXO3A)] and two pro-inflammatory cytokines [interleukin 1β (IL-1β) and IL-6] genes, using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR)...
October 7, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29726717/anti-oxidant-anti-inflammatory-and-anti-apoptotic-effects-of-zinc-supplementation-in-experimental-induced-diabetic-rat-testes
#4
Neven M Aziz, Maha Yehia Kamel, Manar Mohamed, Sabreen Ahmed
AIM: One of the major obstacles that male diabetics may confront is sub-infertility and infertility. Thus the present study aims at investigating the role of co-administration of metformin and zinc (Zn) on the testes of streptozotocin (STZ)-induced diabetic rat. MATERIALS AND METHODS: Male albino rats were randomly divided into four groups: Control group; Diabetic non treated group; Diabetic + Metformin group, in which diabetic rats were treated by metformin 250 mg/kg orally once daily for 4 weeks; Diabetic + Metformin+ Zn group, in which diabetic rats treated for 4 weeks by metformin in combination with Zn 10mg/kg, orally once daily...
May 4, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29716402/-significance-of-the-examination-of-the-metal-element-content-of-herbal-extracts-in-adjuvant-therapy
#5
Klára Szentmihályi
The consumption of herbal teas is becoming more and more popular nowadays both as luxury foods and a complementary part of medical therapy. Beside the organic agents of medicinal plants, the presence of inorganic ions is also relevant in exerting the favorable pharmacological effect. The author briefly summarizes the importance of some essential metal ions and their quantitative values in teas applied in the adjuvant therapy of diabetes and used as diuretics. The common feature of teas used in diabetes is that they contain a measurable amount of chromium and the concentration of most essential elements (such as K, Mg, Mn and Zn) is significant, which can be considered as a mineral source for some metal ions...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29681164/effect-of-diet-with-carbohydrate-but-without-daily-energy-restriction-on-serum-glucose-lactate-and-selected-mineral-and-lipid-levels-in-streptozotocin-induced-experimental-diabetic-rats
#6
Osman Sinan Ozsezen, Ismail Meral
OBJECTIVE: Type I diabetes is a disease characterised by an extreme reduction in serum insulin levels. Diet and exercise have gained considerable attention in the treatment of diabetes. Therefore, this study was carried out to investigate the effect of diet with carbohydrate but without daily energy restriction on various metabolites (glucose, triglycerides, cholesterol, lactate), some electrolytes (Ca, Mg, Na, K, P, Cl) and essential metals (Mn, Co, Cu, Se, Zn, Fe) in the blood of rats with streptozotocin-induced diabetes...
April 21, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29629481/trace-elements-in-saliva-as-markers-of-type-2-diabetes-mellitus
#7
Luis Marín Martínez, Diana Molino Pagán, Pía López Jornet
To analyze Mg, Ca, and Zn levels in saliva, comparing patients with type 2 diabetes mellitus and a control group of healthy subjects. This transversal, observational, clinical study included a total sample of 147 patients, 74 with type 2 diabetes mellitus and a control group of 73 healthy subjects. Socio-demographic, anthropometric, diabetological, and metabolic variables were registered. Trace elements in non-stimulated basal saliva were measured using inductively coupled plasma mass spectrometry (ICP-MS): Mg, Ca, and Zn...
April 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29618936/trace-elements-and-oxidative-stress-in-children-with-type-1-diabetes-mellitus
#8
Ashgan Abdalla Alghobashy, Usama M Alkholy, Mohamed A Talat, Nermin Abdalmonem, Ahmed Zaki, Ihab A Ahmed, Randa H Mohamed
Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D. Methods: A case-control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29546305/the-inflammatory-potential-of-the-diet-at-midlife-is-associated-with-later-healthy-aging-in-french-adults
#9
Karen E Assmann, Moufidath Adjibade, Nitin Shivappa, James R Hébert, Michael D Wirth, Mathilde Touvier, Tasnime Akbaraly, Serge Hercberg, Pilar Galan, Chantal Julia, Emmanuelle Kesse-Guyot
Background: While low-grade chronic inflammation has been suggested as a major modulator of healthy aging (HA), no study has yet investigated the link between the inflammatory potential of the diet and multidimensional concepts of HA. Objective: We aimed to evaluate the association between the inflammatory potential of the diet at midlife, as measured by the Dietary Inflammatory Index (DII), and HA assessed 13 y later. Methods: We analyzed data from 2796 participants in the French Supplémentation en Vitamines et Minéraux Antioxydants (SU...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29485914/streptozotocin-induced-autophagy-reduces-intracellular-insulin-in-insulinoma-ins-1e-cells
#10
Yeong-Min Yoo, Yung Chul Park
Streptozotocin (STZ), a glucose analog, induces diabetes in experimental animals by inducing preferential cytotoxicity in pancreatic beta cells. We investigated whether STZ reduced the production of intracellular insulin through autophagy in insulinoma INS-1E cells. Typically, 2 mM STZ treatment for 24 h significantly decreased cell survival. STZ treatment led to significant decrease in phospho-AMP-activated protein kinase (p-AMPK) level; reduction in levels of phospho-protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme 1α (IRE1α); significant reduction in levels of p85α, p110, phospho-serine and threonine kinase/protein kinase B (p-Akt/PKB) (Ser473), phospho-extracellular-regulated kinase (p-ERK), and phospho-mammalian target of rapamycin (p-mTOR); increase in levels of Cu/Zn-superoxide dismutase (SOD), Mn-SOD, and catalase; decrease in B-cell lymphoma 2 (Bcl-2) expression; increase in Bcl-2-associated X protein (Bax) expression; increase in levels of microtubule-associated protein 1 light chain 3 (LC3) and Beclin 1; and reduction in production of intracellular insulin...
March 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29421993/zinc-supplementation-does-not-influence-serum-levels-of-vegf-bdnf-and-ngf-in-diabetic-retinopathy-patients-a-randomized-controlled-clinical-trial
#11
Sorayya Kheirouri, Siamak Naghizadeh, Mohammad Alizadeh
OBJECTIVES: This study was aimed to evaluate the effects of zinc (Zn) supplementation on serum levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with diabetic retinopathy (DR). METHODS: In this randomized clinical trial, 50 patients with DR were allocated into the Zn (n = 25) and placebo (n = 25) groups to receive 30 mg Zn gluconate or maltose dextrin per day, respectively, for three months...
February 8, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29413101/the-beneficial-effects-of-zn-on-akt-mediated-insulin-and-cell-survival-signaling-pathways-in-diabetes
#12
REVIEW
Weixia Sun, Jiaxing Yang, Wanning Wang, Jie Hou, Yanli Cheng, Yaowen Fu, Zhonggao Xu, Lu Cai
Zinc is one of the essential trace elements and participates in numerous physiological processes. Abnormalities in zinc homeostasis often result in the pathogenesis of various chronic metabolic disorders, such as diabetes and its complications. Zinc has insulin-mimetic and anti-diabetic effects and deficiency has been shown to aggravate diabetes-induced oxidative stress and tissue injury in diabetic rodent models and human subjects with diabetes. Akt signaling pathway plays a central role in insulin-stimulated glucose metabolism and cell survival...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29322001/evaluation-of-the-antidiabetic-property-of-aqueous-leaves-extract-of-zanthoxylum-armatum-dc-using-in-vivo-and-in-vitro-approaches
#13
Carey Vana Rynjah, Ningthoujam Neelima Devi, Nasheman Khongthaw, Donkupar Syiem, Suktilang Majaw
The present study was designed to evaluate the antidiabetic potential of the aqueous leaves extract of Zanthoxylum armatum DC. leaves using in vivo and in vitro approaches. For in vivo studies, blood glucose level was monitored at different intervals after administration of varying doses of the extract for its hypoglycemic (100-6000 mg/kg b.w.) and antihyperglycemic (250 mg/kg b.w.) effect in normoglycemic and diabetic mice. In vitro enzymatic inhibition activity was tested against α-amylase, α- and β-glucosidase and lipase...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319901/gomisin-a-modulates-aging-progress-via-mitochondrial-biogenesis-in-human-diploid-fibroblast-cells
#14
Jeong-Seok Kim, Seon-Hwa Jeong, Sin-Hee Han, Ho-Keun Yi
Gomisin A from the fruit of Schisandra chinensis has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative stress. However, the potential benefit of gomisin A is still not well understood, especially in aging progression. Therefore, the aim of this study was to clarify whether the promotion of mitochondrial biogenesis and autophagy of gomisin A affects anti-aging progression, and its mechanism. Intermediate (PD32) human diploid fibroblast (HDF) cells were brought to stress-induced premature senescence (SIPS) using hydrogen peroxide...
January 10, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29215553/anti-diabetic-effect-of-organo-chalcogen-sulfur-and-selenium-zinc-complexes-with-hydroxy-pyrone-derivatives-on-leptin-deficient-type-2-diabetes-model-ob-ob-mice
#15
Takayuki Nishiguchi, Yutaka Yoshikawa, Hiroyuki Yasui
Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Zn complexes elicit strong anti-diabetic effects. In this study, we treated leptin-deficient ob/ob mice with organo-chalcogen Zn complexes, and evaluated the resulting anti-diabetic effects in a mouse model of diabetes arising from pathogenic mechanisms different from those in KKAy mice...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29169989/a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-18-deficiency-leads-to-visceral-adiposity-and-associated-metabolic-syndrome-in-mice
#16
Rui Zhu, Mengting Cheng, Tiantian Lu, Ning Yang, Shuai Ye, Yi-Hsuan Pan, Tao Hong, Suying Dang, Wei Zhang
Visceral adiposity is of greater risk than obesity in s.c. adipose tissue for diabetes and cardiovascular disease. Its pathogenesis remains unclear, but it is associated with extracellular matrix (ECM) remodeling. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are a family of secreted zinc-dependent metalloproteinases that play crucial roles in development and various diseases because of their ECM remodeling activity. ADAMTS18 is an orphan ADAMTS whose function and substrate remain unclear...
February 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29137144/impact-of-labile-zinc-on-heart-function-from-physiology-to-pathophysiology
#17
REVIEW
Belma Turan, Erkan Tuncay
Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn2+ . Although Zn2+ concentration is in the nM range in cardiomyocytes at rest and increases dramatically under stimulation, very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function. Recent studies are focused on molecular and cellular aspects of labile Zn2+ and its homeostasis in mammalian cells and growing evidence clarified the molecular mechanisms underlying Zn2+ -diverse functions in the heart, leading to the discovery of novel physiological functions of labile Zn2+ in parallel to the discovery of subcellular localization of Zn2+ -transporters in cardiomyocytes...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29102937/beneficial-effect-of-bis-hinokitiolato-zn-complex-on-high-fat-diet-induced-lipid-accumulation-in-mouse-liver-and-kidney
#18
Yuki Naito, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Akiko Takenouchi, Hiroyuki Yasui
BACKGROUND/AIM: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato)Zn, [Zn(hkt)2 ] on lipid metabolism in the liver and kidney, histopathologically. MATERIALS AND METHODS: We used a high-fat diet (HFD)-fed C57BL/6J mouse model and administered a diet containing 10-20 mg Zn/kg body weight (BW) or 20 mg pioglitazone/kg BW as the positive control...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29079702/metallothionein-preserves-akt2-activity-and-cardiac-function-via-inhibiting-trb3-in-diabetic-hearts
#19
Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild-type (WT) male FVB mice, which was accompanied by attenuation of Akt downstream glucose metabolic signal. All of these signal changes were not observed in metallothionein cardiac-specific transgenic (MT-TG) hearts. Furthermore, insulin-induced glucose metabolic signals were attenuated only in WT diabetic hearts...
March 2018: Diabetes
https://www.readbyqxmd.com/read/29073545/in-vitro-structure-specific-zn-ii-induced-adipogenesis-and-structure-function-bioreactivity-correlations
#20
E Halevas, O Tsave, M Yavropoulou, J G Yovos, A Hatzidimitriou, V Psycharis, A Salifoglou
The advent of Zn(II) metallodrugs in metabolic syndrome pathologies generates a strong challenge toward synthetic endeavors targeting well-defined, atoxic and biologically active binary/ternary species of Zn(II). Proper formulation of that metal ion's coordination sphere sets the stage for construction of appropriately configured Schiff ligands based on tromethamine and variably modified vanillin core components. The arising Schiff ligands react with Zn(II) in a defined stoichiometry, thereby delivering new binary Zn(II)-L species with defined physicochemical properties...
December 2017: Journal of Inorganic Biochemistry
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