keyword
https://read.qxmd.com/read/38513314/second-order-scattering-sensor-based-on-the-zn-0-97-la-0-03-o-compound-for-selective-and-stable-detection-of-glycated-albumin
#1
JOURNAL ARTICLE
José Jonathan Soares Dos Santos, Ramon Raudel Peña Garcia, Adriano Santana Soares, Elias Gabriel de Amorim Silva, Jorge Luiz Neves, Thaís Meira Menezes
Here, we presented a second-order scattering sensor based on the Zn0.97 La0.03 O compound (LaZnO) for selective and stable detection of glycated albumin (GA, glycemic long-term biomarker). The LaZnO sample was obtained through the co-precipitation method and then characterized using microscopic and spectroscopic techniques. Furthermore, the selectivity, molecular interference, temporal stability, and pH effects of the LaZnO SOS signal in the absence and presence of GA were investigated. The results indicate the stability of the SOS signal over more than 60 days...
March 19, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38499796/evaluation-study-of-single-anastomosis-duodenal-ileal-bypass-with-sleeve-gastrectomy-in-the-treatment-of-chinese-obese-patients-based-on-efficacy-and-nutrition
#2
JOURNAL ARTICLE
Lifu Hu, Lun Wang, Shixing Li, Yang Liu, Zheng Zhang, Minghao Xiao, Zhenhua Zhang, Zhiqiang Wei, Liang Cui, Tao Jiang
To evaluate the efficacy and nutrition of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in Chinese obese patients in the first postoperative year. Clinical data of 66 obese patients who underwent SADI-S surgery at China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were retrospectively collected. The weight, body mass index (BMI), percentage of excess weight loss (%EWL), and percentage of total weight loss (%TWL) were recorded at 3, 6, and 12 months after surgery...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38484635/plasma-levels-and-dietary-intake-of-minerals-in-patients-with-type-2-diabetes-and-chronic-kidney-disease-a-case-control-study
#3
JOURNAL ARTICLE
Mudili Sivaprasad, Tattari Shalini, Manisha Sahay, Rakesh Sahay, Manavalan Satyanarayanan, G Bhanuprakash Reddy
BACKGROUND AND AIM: Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease (CKD) worldwide. Altered mineral levels leading to adverse outcomes are widely reported in diabetes but limited in DKD, in the Indian scenario, hence this study was taken up to address this issue. METHODS: A hospital-based case-control study was taken up with 54 healthy controls (C) and 140 subjects with type 2 diabetes wherein 74 subjects with diabetes and CKD formed the DKD group, and 66 subjects with diabetes but no CKD formed the diabetic no-chronic kidney disease (DNCKD) group...
March 4, 2024: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/38459117/mixture-effects-of-trace-element-levels-on-cardiovascular-diseases-and-type-2-diabetes-risk-in-adults-using-g-computation-analysis
#4
JOURNAL ARTICLE
Borhan Mansouri, Ayoob Rezaei, Kiomars Sharafi, Nammamali Azadi, Meghdad Pirsaheb, Maryam Rezaei, Samaneh Nakhaee
There is an increasing concern about the health effects of exposure to a mixture of pollutants. This study aimed to evaluate the associations between serum levels of heavy/essential metals ([Arsenic (As), Cadmium (Cd), Mercury (Hg), Lead (Pb), Nickel (Ni), Chromium (Cr), Copper (Cu), Iron (Fe), and Zinc (Zn)]) and the risk of developing cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2D). Data were collected from 450 participants (150 with CVDs, 150 with T2D, and 150 healthy subjects) randomly selected from the Ravansar Non-Communicable Disease (RaNCD) cohort in Western Iran, covering the years 2018-2023...
March 8, 2024: Scientific Reports
https://read.qxmd.com/read/38418147/zinc-alpha-2-glycoprotein-acylated-ghrelin-and-zinc-levels-in-prediabetics
#5
JOURNAL ARTICLE
Eda Merve Kurtuluş, Denizhan Kariş, Alev Meltem Ercan, Dildar Konukoğlu
BACKGROUND/AIM: Prediabetic stages of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) exhibit differences in the sites of insulin resistance. Serum Zinc α-2 glycoprotein (ZAG), acylated ghrelin (AG), and zinc (Zn) levels can affect IFG, IGT, and diabetic glucose tolerance (DGT) differently. This study examined the importance of ZAG, AG, and serum Zn levels in prediabetic individuals with IFG, IGT, and DGT, compared to those with normal glucose levels. PATIENTS AND METHODS: The study was conducted at İstanbul University Cerrahpaşa-Cerrahpaşa Faculty of Medicine...
2024: In Vivo
https://read.qxmd.com/read/38397536/an-in-silico-in-vitro-and-in-vivo-study-on-the-influence-of-an-eggplant-fruit-solanum-anguivi-lam-diet-on-metabolic-dysfunction-in-the-sucrose-induced-diabetic-like-fruit-fly-drosophila-melanogaster
#6
JOURNAL ARTICLE
Esther Nwanna, Roseline Ojo, Nusrat Shafiq, Awais Ali, Emmanuel Okello, Ganiyu Oboh
Introduction: Africa faces immense food and health insecurity challenges, a problem partly attributed to food loss and waste during postharvest handling and distribution. In the context of research to meet the sustainable development goals, this project specifically addressed the postharvest loss of the ripe indigenous eggplant ( Solanum anguivi lam) fruit called "Igba Yinrin" by Yoruba in South-West Nigeria, which is usually discarded in farms. The study was carried out on ripe and unripe fruits to better understand their value by comparing their effects in diabetes treatment...
February 12, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38390362/colorimetric-sensing-of-hydrogen-peroxide-using-capped-morus-nigra-sawdust-deposited-zinc-oxide-nanoparticles-via-trigonella-foenum-extract
#7
JOURNAL ARTICLE
Umar Nishan, Tabassum Zahra, Amir Badshah, Nawshad Muhammad, Saifullah Afridi, Mohibullah Shah, Naeem Khan, Muhammad Asad, Riaz Ullah, Essam A Ali, Ke Chen
Hydrogen peroxide (H2 O2 ) is one of the main byproducts of most enzymatic reactions, and its detection is very important in disease conditions. Due to its essential role in healthcare, the food industry, and environmental research, accurate H2 O2 determination is a prerequisite. In the present work, Morus nigra sawdust deposited zinc oxide (ZnO) nanoparticles (NPs) were synthesized by the use of Trigonella foenum extract via a hydrothermal process. The synthesized platform was characterized by various techniques, including UV-Vis, FTIR, XRD, SEM, EDX, etc...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38374189/grain-iron-and-zinc-content-is-independent-of-anthocyanin-accumulation-in-pigmented-rice-genotypes-of-northeast-region-of-india
#8
JOURNAL ARTICLE
Smrita Gogoi, Sanjay Singh, B P Mallikarjuna Swamy, Priyanka Das, Debojit Sarma, Ramendra Nath Sarma, Sumita Acharjee, Sharmila Dutta Deka
The traditional rice genotypes of Assam are considered to have biological value due to the presence of several bioactive compounds like flavonoids, polyphenols, and anthocyanins, which have antioxidant, anti-cancer, anti-diabetic, and anti-aging properties. The pigmented genotypes are considered to have high iron (Fe) content. However, the effect of Fe and Zinc (Zn) accumulation on anthocyanin content is yet to be studied in pigmented rice of Assam. We studied the Fe, Zn, and anthocyanin content in grains of 204 traditional rice of Assam, which are traditionally preferred for their nutraceutical properties...
February 19, 2024: Scientific Reports
https://read.qxmd.com/read/38367088/ethnobotanical-ecological-and-health-risk-assessment-of-some-selected-wild-medicinal-plants-collected-along-mafic-and-ultra-mafic-rocks-of-northwest-pakistan
#9
JOURNAL ARTICLE
Irfan Ullah, Muhammad Adnan, Javed Nawab, Sardar Khan
The current study investigated wild plant resources and health risk assessment along with northern Pakistan's mafic and ultramafic regions. Ethnobotanical data was collected through field visits and semi-structured questionnaire surveys conducted from local inhabitants and healers. Six potentially toxic elements (PTEs) such as lead (Pb), cadmium (Cd), nickel (Ni), chromium (Cr), manganese (Mn), and zinc (Zn) were extracted with acids and analyzed using atomic absorption spectrophotometer (AAS, Perkin Elmer-7000) in nine selected wild medicinal plants...
February 17, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38327957/revisiting-the-era-of-intestinal-tuberculosis-a-case-presenting-as-small-bowel-obstruction-with-classical-imaging-and-histopathological-appearances
#10
Kajal Hatgoankar, Anand Hatgaonkar, Pratibha Dawande
The incidence of tuberculosis (TB) worldwide is still significantly high, with India contributing a high global TB burden. This case study features a 49-year-old male who had complaints of pain and abdominal distention for one and a half months. An erect abdominal radiograph showed features suggesting small bowel obstruction. Contrast-enhanced computed tomography (CT) of the abdomen was done. It showed multiple strictures involving the distal jejunum and ileum, causing small bowel obstruction. There was mesenteric and retroperitoneal lymphadenopathy with central necrosis and ascites...
January 2024: Curēus
https://read.qxmd.com/read/38258780/the-effect-of-selenium-zinc-and-their-combined-supplementation-on-cardiometabolic-biomarkers-comparing-their-effects-in-the-energy-restriction-and-high-fat-diet-methods-in-obese-rats
#11
JOURNAL ARTICLE
Motahareh Hasani, Vahid Monfared, Elahe Aleebrahim-Dehkordi, Ali Jafari, Fahimeh Agh, Maryam Khazdouz, Farhad Vahid, Mohammadreza Vafa
INTRODUCTION: The fat distribution in the body determines the risk of cardiometabolic problems such as heart disease and diabetes. Some dietary supplements, such as selenium and zinc, possess lipolytic and anti-angiogenic functions, which may be a useful strategy in reducing the risk of cardiometabolic complications. This study evaluated the effect of zinc (Zn), selenium (Se), and their combined supplementation on cardiometabolic risk factors in male Wistar rats in two nutritional models, including caloric restriction (CR) and high-fat diet (HFD)...
January 22, 2024: Current Molecular Medicine
https://read.qxmd.com/read/38201287/is-environmental-cadmium-exposure-causally-related-to-diabetes-and-obesity
#12
REVIEW
Soisungwan Satarug
Cadmium (Cd) is a pervasive toxic metal, present in most food types, cigarette smoke, and air. Most cells in the body will assimilate Cd, as its charge and ionic radius are similar to the essential metals, iron, zinc, and calcium (Fe, Zn, and Ca). Cd preferentially accumulates in the proximal tubular epithelium of the kidney, and is excreted in urine when these cells die. Thus, excretion of Cd reflects renal accumulation (body burden) and the current toxicity of Cd. The kidney is the only organ other than liver that produces and releases glucose into the circulation...
December 30, 2023: Cells
https://read.qxmd.com/read/38192249/effect-of-different-nutrients-on-blood-glucose-inflammatory-response-and-oxidative-stress-in-gestational-diabetes-mellitus-a-network-meta-analysis
#13
REVIEW
Lingling Yu, Yuan Zhu, Lan Geng, Yueming Xu, Mei Zhao
We searched PubMed, Web of Science, Embase, The Cochrane Library, China Biomedical Literature Database and other databases from inception to June 2023. The included studies were randomised controlled trials (RCT). The studies were screened by four authors, divided into two independent pairs. A total of eighteen studies were included, including 1362 patients, involving twelve intervention measures. The different nutrients had a significant effect on improving blood glucose, reducing inflammation levels and reducing oxidative stress compared with placebo (P < 0...
January 9, 2024: British Journal of Nutrition
https://read.qxmd.com/read/38184650/a-role-and-mechanism-for-redox-sensing-by-senp1-in-%C3%AE-cell-responses-to-high-fat-feeding
#14
JOURNAL ARTICLE
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia P Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick E MacDonald
Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans without diabetes and mice fed a high-fat diet for 2 days, insulin exocytosis and secretion are enhanced without increased Ca2+ influx. RNA-seq of sorted β-cells suggests altered metabolic pathways early following high fat diet, where we find increased basal oxygen consumption and proton leak, but a more reduced cytosolic redox state...
January 6, 2024: Nature Communications
https://read.qxmd.com/read/38139275/dysregulated-mirna-375-il-17-tgf-%C3%AE-and-microminerals-are-associated-with-calpain-10-snp-19-in-diabetic-patients-correlation-with-diabetic-nephropathy-stages
#15
JOURNAL ARTICLE
Ghada M Ezzat, Nashwa Mostafa A Azoz, Randa A El Zohne, HebatAllah Abdellatif, Tahia H Saleem, Wafaa Abdelaziz Emam, Amena Rezk Mohammed, Shimaa Ali Mohamed, Asmaa A Muhammed, Nessren M Abd El-Rady, Marwa Hamdy, Hoda S Sherkawy, Marwa A Sabet, Salwa Seif Eldin, Marwa A Dahpy
Zinc (Zn) and copper (Cu) have been shown to have the potential to improve glucose metabolism through interactions with cytokines and signaling events with multiple genes. miRNA-375 and the Calpin-10 gene are potential genetic biomarkers for the early prediction of diabetic nephropathy (DN). 128 healthy controls and 129 type 2 diabetic (T2DM) participants were matched for age and sex. Three subgroups were identified from the T2DM group: 39 patients had microalbuminuria, 41 had macroalbuminuria, and 49 patients had renal problems...
December 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38125730/combined-exposure-to-multiple-essential-elements-and-cadmium-at-early-pregnancy-on-gestational-diabetes-mellitus-a-prospective-cohort-study
#16
JOURNAL ARTICLE
Guifang Deng, Hengying Chen, Yao Liu, Yingyu Zhou, Xiaoping Lin, Yuanhuan Wei, Ruifang Sun, Zheqing Zhang, Zhenhe Huang
BACKGROUND: Minerals and trace elements were involved in the pathogenesis and progression of diabetes. However, the association of mixed exposure to essential elements and toxic elements with gestational diabetes mellitus (GDM) is poorly understood. OBJECTIVE: This study aims to examine the associations between serum calcium (Ca), iron (Fe), zinc (Zn), copper (Cu), magnesium (Mg), and cadmium (Cd) concentrations in early pregnancy and GDM risk in Chinese pregnant women...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/38116651/association-between-dietary-antioxidants-intake-and-the-risk-of-type-2-diabetes-mellitus-in-a-prospective-cohort-study-tehran-lipid-and-glucose-study
#17
JOURNAL ARTICLE
M Golmohamadi, S Hosseinpour-Niazi, P Hadaegh, P Mirmiran, F Azizi, F Hadaegh
The present prospective cohort study aimed to determine whether dietary antioxidants were associated with incident type 2 diabetes mellitus (T2DM). Another objective was to find out whether such associations could be modified by the body mass index (BMI) status. A total of 2188 Tehranian adults aged 21-84 years, free of T2DM with the validated Food Frequency Questionnaire was entered in the study. Multivariable Cox proportional hazards models adjusting for confounders were used to assess the association between dietary antioxidants and incident T2DM in total population, as well as in subjects with various BMI statuses...
December 20, 2023: British Journal of Nutrition
https://read.qxmd.com/read/38065251/effect-of-angiotensin-converting-enzyme-inhibitor-and-angiotensin-receptor-blocker-on-oxidative-stress-and-metabolism-of-elements-in-kidney-of-stz-induced-diabetic-rats
#18
JOURNAL ARTICLE
Nural Pastacı Özsobacı, Metehan Karataş, Matem Tuncdemir, Dervis Özcelik
In diabetes, increased oxidative stress and impaired trace element metabolism play an important role in the pathogenesis of diabetic nephropathy. The objective of this research was to examine the outcomes of blocking the renin-angiotensin system, using either the angiotensin-converting enzyme inhibitor (ACEI), perindopril, or the angiotensin II type 1 (AT1) receptor blocker, irbesartan, on oxidative stress and trace element levels such as Zn, Mg, Cu, and Fe in the kidneys of diabetic rats that had been induced with streptozotocin...
December 6, 2023: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38045569/zn-fe-primary-battery-enabled-controlled-hydrogen-release-in-stomach-for-improving-insulin-resistance-in-obesity-associated-type-2-diabetes
#19
JOURNAL ARTICLE
Boyan Liu, Peixun Lv, Xiaoyi Zhang, Chao Xia, Xinru Liu, Jingyu Liu, Junli Xue, Qianjun He, Shucun Qin
Chronic systemic inflammation in obesity-associated type 2 diabetes (T2D) is a key inducing factor of insulin resistance (IR). Hydrogen molecule (H2 ) has been proved to be a safe and effective anti-inflammatory agent, but conventional H2 administration methods cannot provide a high dosage and a long duration of H2 treatment in IR-related tissues and thus lead to limited therapeutic efficacies. We here propose a new strategy of controlled H2 release to match the time window of gastric emptying for maximizing the bioavailability and therapeutic outcome of H2 ...
March 2024: Bioactive Materials
https://read.qxmd.com/read/38029632/three-state-dynamics-of-zinc-ii-complexes-yielding-significant-antidiabetic-targets
#20
JOURNAL ARTICLE
Nousheen Parvaiz, Asma Abro, Syed Sikander Azam
Protein Tyrosine Phosphatase 1B (PTP1B), being negative regulator of insulin signaling pathways is considered as potential medicinal target. Selective and targeted inhibitors for PTP1B can impact the therapeutic options available to cure chronic illness such as diabetes. Significant research evidence including computational studies on the role of Zn2+ in binding and inhibiting the catalytic pocket have been reported along with experimental exploration of zinc(II) complexes as potent inhibitors of the enzyme...
November 2, 2023: Journal of Molecular Graphics & Modelling
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