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https://www.readbyqxmd.com/read/29923427/renoprotective-effects-of-canagliflozin-a-sodium-glucose-cotransporter-2-inhibitor-in-type-2-diabetes-patients-with-chronic-kidney-disease-a-randomized-open-label-prospective-trial
#1
Hiroyuki Takashima, Yoshinori Yoshida, Chinami Nagura, Tetsuya Furukawa, Ritsukou Tei, Takashi Maruyama, Noriaki Maruyama, Masanori Abe
BACKGROUND: To evaluate the renoprotective effects of canagliflozin, we assessed the albuminuria-lowering effect in Japanese type 2 diabetes patients with chronic kidney disease (CKD). METHODS: In this prospective, open-label, parallel-group study, type 2 diabetes patients with CKD were randomized to receive either oral canagliflozin (100 mg/day) or usual care (control group) for 52 weeks. Endpoints included changes in urinary albumin-to-creatinine ratio (UACR), other urinary biomarkers, laboratory parameters, and adverse events...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29909935/ckd-and-sedentary-time-results-from-the-canadian-health-measures-survey
#2
Tamara Glavinovic, Thomas Ferguson, Paul Komenda, Claudio Rigatto, Todd A Duhamel, Navdeep Tangri, Clara Bohm
RATIONALE & OBJECTIVE: Sedentary behavior and low physical activity are associated with incident diabetes, cardiovascular disease, and early mortality. Previous studies have examined associations between chronic kidney disease (CKD) and physical activity, but little is known about the role of sedentary time. STUDY DESIGN: Cross-sectional national survey. SETTING & PARTICIPANTS: A nationally representative sample of adults (n=8,444) participating in the Canadian Health Measures Survey's (CHMS) activity monitoring component (2007-2013)...
June 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29906428/effects-of-coffee-intake-on-incident-chronic-kidney-disease-community-based-prospective-cohort-study
#3
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29903699/a-putative-role-of-apolipoprotein-l1-polymorphism-in-renal-parenchymal-scarring-following-febrile-urinary-tract-infection-in-nigerian-under-five-children-proposal-for-a-case-control-association-study
#4
Emmanuel Ademola Anigilaje
BACKGROUND: Although urinary tract infection (UTI) resolves with prompt treatment in a majority of children, some children, especially those aged less than 5 years, also develop renal parenchymal scarring (RPS). RPS causes high blood pressure that may lead to severe chronic kidney disease and end-stage renal disease (ESRD). Although the risk of UTI is higher in white children than in black children, it is unknown whether RPS is more common in white children than in black children as data are scarce in this regard...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29899374/role-and-prognostic-value-of-individual-ambulatory-blood-pressure-components-in-chronic-kidney-disease
#5
Fabio Angeli, Giorgio Gentile, Monica Trapasso, Paolo Verdecchia, Gianpaolo Reboldi
Hypertension is a key risk factor for chronic kidney disease (CKD), but can also be a detrimental consequence of established CKD. Unsurprisingly, the majority of subjects with abnormal creatinine in the general population are also hypertensive, with a huge toll on national health care systems worldwide due to a staggering increase in the risk of cardiovascular complications and end-stage renal disease requiring renal replacement therapy. In this setting, a comprehensive and careful assessment of the whole 24-h blood pressure (BP) profile could be of paramount importance in ensuring a timely diagnosis of hypertension and an optimal therapeutic control...
June 13, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29898785/effectiveness-of-self-management-support-interventions-for-people-with-comorbid-diabetes-and-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#6
Edward Zimbudzi, Clement Lo, Marie L Misso, Sanjeeva Ranasinha, Peter G Kerr, Helena J Teede, Sophia Zoungas
BACKGROUND: Self-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of these interventions remains unclear. We investigated the effectiveness of current self-management support interventions and their specific components and elements in improving patient outcomes. METHODS: Electronic databases were systematically searched from January 1, 1994, to December 19, 2017...
June 13, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29897288/intermittent-hypoxia-exacerbates-increased-blood-pressure-in-rats-with-chronic-kidney-disease
#7
Jennifer L Riggs, Carolyn E Pace, Heather H Ward, Laura V Gonzalez Bosc, Lynnette Rios, Adleaeda Barrera, Nancy L Kanagy
Kidney injury and sleep apnea (SA) are independent risk factors for hypertension. Exposing rats to intermittent hypoxia (IH) to simulate SA increases blood pressure while adenine feeding causes persistent kidney damage to model chronic kidney disease (CKD). We hypothesized that exposing CKD rats to IH would exacerbate the development of hypertension and renal failure. Male Sprague-Dawley rats were fed a 0.2% adenine or control diet until blood urea nitrogen (BUN) was &gt; 120 mg/dL in adenine fed rats (14 {plus minus} 4 days)...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29896409/urinary-neutrophil-gelatinase-associated-lipocalin-is-excellent-predictor-of-acute-kidney-injury-in-septic-elderly-patients
#8
Erica Pires da Rocha, Lais Gabriela Yokota, Beatriz Motta Sampaio, Karina Zanchetta Cardoso Eid, Dayana Bitencourt Dias, Fernanda Moreira de Freitas, Andre Luis Balbi, Daniela Ponce
Elderly is the main age group affected by acute kidney injury (AKI). There are no studies that investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic elderly population. This study aimed to evaluate the efficacy of uNGAL as predictor of AKI diagnosis and prognosis in elderly septic patients admitted to ICUs. We prospectively studied elderly patients with sepsis admitted to ICUs from October 2014 to November 2015. Assessment of renal function was performed daily by serum creatinine and urine output...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29893643/regional-cerebral-blood-flow-in-children-and-young-adults-with-chronic-kidney-disease
#9
Hua-Shan Liu, Erum A Hartung, Abbas F Jawad, Jeffrey B Ware, Nina Laney, Allison M Port, Ruben C Gur, Stephen R Hooper, Jerilynn Radcliffe, Susan L Furth, John A Detre
Purpose To investigate the pathophysiologic effects of chronic kidney disease (CKD) on brain function in children with CKD by correlating cerebral blood flow (CBF) with clinical and behavioral indexes. Materials and Methods In this prospective study, 73 pediatric patients with CKD (mean age, 15.80 years ± 3.63; range, 9-25 years) and 57 control subjects (mean age, 15.65 years ± 3.76; range, 9-25 years) were recruited. CBF measurements were acquired with an MRI arterial spin labeling scheme. Neurocognitive measurements were performed with traditional and computerized neurocognitive batteries...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29893616/prevalence-and-risk-factors-for-periodontitis-among-patients-with-metabolic-syndrome
#10
Ho Seok Koo, Soo Min Hong
BACKGROUND: The incidence of periodontitis is higher when metabolic syndrome (MS) is present. However, only few Korean studies have compared the risk factors for MS and periodontitis. Therefore, this study aimed to investigate the prevalence and risk factors for periodontitis relative to the presence of MS. METHODS: The data collected from 13,196 respondents of the 2010-2015 Korea National Health and Nutrition Examination Survey in South Korea, which include periodontitis and MS parameters, were analyzed after propensity score matching of sex and age...
June 12, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29892833/treatment-of-hypertension-in-chronic-kidney-disease
#11
REVIEW
Rigas G Kalaitzidis, Moses S Elisaf
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is recognized as a worldwide epidemic. Hypertension commonly coexists with CKD and its prevalence is progressively increasing as kidney function declines. RECENT FINDINGS: For patients with established CKD and/or diabetes with albuminuria, the updated hypertension guidelines have recommended a blood pressure (BP) goal < 130/80 mmHg. Blood pressure level above 130/80 mmHg in CKD patients requires lifestyle modifications and multiple antihypertensive medications...
June 11, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29892340/declining-trends-of-diabetic-nephropathy-retinopathy-and-neuropathy-with-improving-diabetes-care-indicators-in-japanese-patients-with-type-2-and-type-1-diabetes-jddm-46
#12
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29889157/do-patients-actually-do-what-we-ask-patient-fidelity-and-persistence-to-the-targets-and-self-management-for-the-control-of-blood-pressure-in-stroke-and-at-risk-groups-blood-pressure-self-management-intervention
#13
Claire L Schwartz, Ashkon Seyed-Safi, Sayeed Haque, Emma P Bray, Shelia Greenfield, F D Richard Hobbs, Paul Little, Jonathan Mant, Bryan Williams, Richard J Mcmanus
OBJECTIVE: Self-management of hypertension can reduce and control blood pressure (BP) compared with clinic monitoring. However, self-management relies on patients following an algorithm, which may be variably adhered to. This study reports fidelity of high-risk patients to the self-management algorithm set by the TASMIN-SR trial. METHODS: Patients with hypertension, above target clinic BP and one or more of stroke, diabetes, coronary heart disease or chronic kidney disease, were invited to self-monitor following an individualized self-titration algorithm...
June 7, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29888950/comparison-of-amlodipine-versus-other-calcium-channel-blockers-on-blood-pressure-variability-in-hypertensive-patients-in-china-a-retrospective-propensity-score-matched-analysis
#14
Lin Zhang, JinKui Yang, LanTing Li, DongDong Liu, XiaoPing Xie, Peng Dong, Yong Lin
AIM: Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-established, long-acting calcium channel blocker (CCB). However, few data are available for amlodipine on blood pressure variability (BPV) in China in a real-world setting. This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV...
June 11, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29888547/efficacy-and-safety-of-dapagliflozin-in-patients-with-type-2-diabetes-and-moderate-renal-impairment-chronic-kidney-disease-stage-3a-the-derive-study
#15
Paola Fioretto, Stefano Del Prato, John B Buse, Ronald Goldenberg, Francesco Giorgino, Daniel Reyner, Anna Maria Langkilde, C David Sjӧstrӧm, Peter Sartipy
AIMS: Dapagliflozin is a selective inhibitor of sodium glucose co-transporter 2 (SGLT2). This study assessed the efficacy and safety of dapagliflozin 10 mg versus placebo in patients with type 2 diabetes (T2D) and moderate renal impairment (estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73m2 ; chronic kidney disease [CKD] stage 3A). MATERIALS AND METHODS: In this double-blind, parallel group, Phase 3 study (NCT02413398, clinicaltrials.gov) patients with inadequately controlled T2D (HbA1c 7...
June 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29888444/the-impact-of-advanced-nurse-practitioners-on-patient-outcomes-in-chronic-kidney-disease-a-systematic-review
#16
Geraldine McCrory, Declan Patton, Zena Moore, Tom O'Connor, Linda Nugent
BACKGROUND: Management of individuals with chronic kidney disease (CKD) requires a collaborative approach. Nurses have diversified their skills to take on roles which have been traditionally physician-led. The impact of such roles, mainly that of the advanced nurse practitioner (ANP), has not been previously assessed using a systematic approach. OBJECTIVES: The aim of this systematic review (SR) was to determine the impact of the addition of an ANP on patient outcomes in adults with CKD...
June 11, 2018: Journal of Renal Care
https://www.readbyqxmd.com/read/29882800/dietary-salt-restriction-in-chronic-kidney-disease-a-meta-analysis-of-randomized-clinical-trials
#17
REVIEW
Carlo Garofalo, Silvio Borrelli, Michele Provenzano, Toni De Stefano, Carlo Vita, Paolo Chiodini, Roberto Minutolo, Luca De Nicola, Giuseppe Conte
BACKGROUND: A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the effects of low versus high salt intake in adult patients with non-dialysis CKD on change in BP, proteinuria and albuminuria...
June 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29875952/agreement-between-home-and-ambulatory-blood-pressure-measurement-in-non-dialysed-chronic-kidney-disease-patients-in-cameroon
#18
Audrey Manto, Anastase Dzudie, Marie Patrice Halle, Léopold Ndemnge Aminde, Martin Hongieh Abanda, Gloria Ashuntantang, Kathleen Ngu Blackett
Introduction: home blood pressure measurement (HBPM) is not entirely capable of replacing ambulatory blood pressure (BP) measurement (ABPM), but is superior to office blood pressure measurement (OBPM). Although availability, cost, energy and lack of training are potential limitations for a wide use of HBPM in Sub-Saharan Africa (SSA), the method may add value for assessing efficacy and compliance in specific populations. We assessed the agreement between HBPM and ABPM in chronic kidney disease (CKD) patients in Douala, Cameroon...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29872964/the-interplay-between-bone-and-vessels-in-pediatric-ckd-lessons-from-a-single-center-study
#19
Evgenia Preka, Bruno Ranchin, Anke Doyon, Melody Vierge, Tiphanie Ginhoux, Behrouz Kassai, Justine Bacchetta
OBJECTIVE: Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. METHODS: This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia...
June 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29872963/waist-to-height-ratio-body-mass-index-and-cardiovascular-risk-profile-in-children-with-chronic-kidney-disease
#20
Kristen Sgambat, Jennifer Roem, Mark Mitsnefes, Anthony A Portale, Susan Furth, Bradley Warady, Asha Moudgil
BACKGROUND: Cardiovascular (CV) risk is high in children with chronic kidney disease (CKD), and further compounded in those who are overweight. Children with CKD have a unique body habitus not accurately assessed by body mass index (BMI). Waist-to-height ratio (WHr), a better predictor of CV risk in populations with short stature, has not been investigated in children with CKD. METHODS: Analysis of 1723 visits of 593 participants enrolled in the Chronic Kidney Disease in Children (CKiD) study was conducted...
June 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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