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chronic kidney disease, blood pressure

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https://www.readbyqxmd.com/read/29457529/n-terminal-pro-b-type-natriuretic-peptide-associated-with-2-year-mortality-from-both-cardiovascular-and-non-cardiovascular-origins-in-prevalent-chronic-hemodialysis-patients
#1
Chihiro Kawagoe, Yuji Sato, Tatsunori Toida, Hideto Nakagawa, Yasuhiro Yamashita, Akihiro Fukuda, Shuji Iwatsubo, Shouichi Fujimoto
N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) was a predictive marker of cardiovascular disease (CVD)-related death in chronic dialysis patients. NT-proBNP was also correlated with markers of inflammation, malnutrition and protein-energy wasting. We hypothesized whether NT-proBNP was also associated with non-CVD death in chronic dialysis patients. A prospective observational study for incidence of death in chronic dialysis patients was conducted. Prevalent chronic dialysis patients (n = 1310) were enrolled and followed for 24 months...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29455212/fetal-risks-and-maternal-renal-complications-in-pregnancy-with-preexisting-chronic-glomerulonephritis
#2
Yuehong Li, Wei Wang, Yujuan Wang, Qi Chen
BACKGROUND Analysis the maternal and fetal risk predictors in pregnancy in conjunction with chronic glomerulonephritis (CGN) patients are helpful to understand the influence of kidney diseases on pregnancy and the effects of pregnancy on kidney diseases. The aim of this study was to determine the predictors of adverse maternal and fetal outcomes in CGN patients. MATERIAL AND METHODS Maternal and fetal outcomes in 64 pregnancies of CGN patients were retrospectively analyzed. We randomly selected 100 low-risk-pregnancy women without chronic kidney disease (CKD) at the same time as the control group...
February 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29450967/carotid-atherosclerosis-and-the-association-between-nocturnal-blood-pressure-dipping-and-cardiovascular-events
#3
Praew Kotruchin, Satoshi Hoshide, Kazuomi Kario
The impact of a nondipping blood pressure (BP) pattern, defined as (awake systolic BP - sleep systolic BP)/awake systolic BP < 0.1, on cardiovascular events in populations with different degrees of carotid atherosclerosis is uncertain. The authors hypothesized that a nondipping BP pattern would show differential predictive power for cardiovascular events, including total cardiovascular death, sudden death, nonfatal cardiovascular events, and nonfatal stroke, between populations with and without carotid atherosclerosis...
February 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29440118/the-enigma-of-blood-pressure-measurement-in-children-with-chronic-kidney-disease
#4
EDITORIAL
Bonita Falkner
No abstract text is available yet for this article.
February 13, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29436384/increasing-mortality-in-adults-with-diabetes-and-low-estimated-glomerular-filtration-rate-in-the-absence-of-albuminuria
#5
Holly Kramer, Robert E Boucher, David Leehey, Linda Fried, Guo Wei, Tom Greene, Sylvia E Rosas, Richard Cooper, Guichan Cao, Srinivasan Beddhu
OBJECTIVE: Improved blood pressure control and use of renin-angiotensin-aldosterone system blockers has altered the clinical presentation or phenotype of chronic kidney disease (CKD) in U.S. adults with diabetes. These changes may influence mortality. RESEARCH DESIGN AND METHODS: Data from the National Health and Nutrition Examination Surveys (NHANES) 1988-2006 were used to examine mortality trends in adults with diabetes, defined as physician diagnosis, fasting glucose ≥126 mg/dL, hemoglobin A 1c >6...
February 7, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29436195/impact-of-ambulatory-blood-pressure-on-early-cardiac-and-renal-dysfunction-in-hypertensive-patients-without-clinically-apparent-target-organ-damage
#6
Darae Kim, Chi Young Shim, Geu Ru Hong, Sungha Park, In Jeong Cho, Hyuk Jae Chang, Jong Won Ha, Namsik Chung
PURPOSE: Impaired left ventricular (LV) global longitudinal strain (GLS) and the presence of microalbuminuria indicate early cardiac and renal dysfunction. We aimed to determine the relationships among 24-h ambulatory blood pressure (BP) variables, LV GLS, and urine albumin creatinine ratio (UACR) in hypertensive patients. MATERIALS AND METHODS: A total of 130 hypertensive patients (mean age 53 years; 59 men) underwent 24-h ambulatory BP monitoring, measurements of peripheral and central BPs, and transthoracic echocardiography...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29425281/at1-receptor-antagonism-improves-structural-functional-and-biomechanical-properties-in-resistance-arteries-in-a-rodent-chronic-kidney-disease-model
#7
K J Quek, O Z Ameer, J K Phillips
Background: The renin-angiotensin system, in particular Angiotensin II (AngII), plays a significant role in the pathogenesis of hypertension in chronic kidney disease (CKD). Effects of chronic AT1 receptor antagonism were investigated in a genetic hypertensive rat model of CKD, the Lewis polycystic kidney (LPK) rat. Methods: Mixed-sex LPK and Lewis control rats (total n=31) were split between treated (valsartan 60mg/kg/day p.o. from 4-18 weeks) and vehicle groups...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29425235/evidence-of-chronic-kidney-disease-in-veterans-with-incident-diabetes-mellitus
#8
Justin Gatwood, Marie Chisholm-Burns, Robert Davis, Fridtjof Thomas, Praveen Potukuchi, Adriana Hung, Csaba P Kovesdy
While chronic kidney disease (CKD) is regularly evaluated among patients with diabetes, kidney function may be significantly impaired before diabetes is diagnosed. Moreover, disparities in the severity of CKD in such a population are likely. This study evaluated the extent of CKD in a national cohort of 36,764 US veterans first diagnosed with diabetes between 2003 and 2013 and prior to initiating oral antidiabetic therapy. Evidence of CKD (any stage) at the time of diabetes diagnosis was determined using eGFR and urine-albumin-creatinine ratios, the odds of which were assessed using logistic regression controlling for patient characteristics...
2018: PloS One
https://www.readbyqxmd.com/read/29424469/effect-of-intensive-blood-pressure-control-in-patients-with-type-2-diabetes-mellitus-over-9-years-of-follow-up-a-subgroup-analysis-of-high-risk-accordion-trial-participants
#9
Leo F Buckley, Dave L Dixon, George F Wohlford, Dayanjan S Wijesinghe, William L Baker, Benjamin W Van Tassell
Although guidelines recommend strict blood pressure (BP) control in patients with type 2 diabetes mellitus (T2DM) and elevated cardiovascular risk, the long-term effects of this approach are unknown. We investigated the effect of intensive BP control on clinical outcomes in patients with T2DM over 9 years of follow-up. We included ACCORD BP participants in the standard glucose control arm who had established cardiovascular disease, chronic kidney disease, age ≥75 years or 10-year coronary heart risk ≥15%...
February 9, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29423914/hypertension-new-perspective-on-its-definition-and-clinical-management-by-bedtime-therapy-substantially-reduces-cardiovascular-disease-risk
#10
REVIEW
Ramón C Hermida, Diana E Ayala, José R Fernández, Artemio Mojón, Michael H Smolensky
Diagnosis of hypertension - elevated blood pressure (BP) associated with increased cardiovascular disease (CVD) risk - and its management for decades have been based primarily on single time-of-day office BP measurements (OBPM) assumed representative of systolic (SBP) and diastolic BP (DBP) during the entire 24h span. Around-the-clock ambulatory blood pressure monitoring (ABPM), however, reveals BP undergoes 24h patterning characterized in normotensives and uncomplicated hypertensives by striking morning-time rise, two daytime peaks - one ~2-3h after awakening and the other early evening, small mid-afternoon nadir, and 10-20% decline (BP dipping) of the asleep BP mean relative to the wake-time BP mean...
February 9, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29412703/a-new-low-nephron-ckd-model-with-hypertension-progressive-decline-of-renal-function-and-enhanced-inflammation-in-c57bl-6-mice
#11
Jin Wei, Jie Zhang, Lei Wang, Byeong Cha, Shan Jiang, Ruisheng Liu
Chronic kidney disease (CKD) is a major health issue in the United States. The typical five-sixths nephrectomy (typical 5/6 NX) is a widely used experimental CKD model. However, the typical 5/6 NX model is hypertensive in rats, but strain dependent in mice. In particular, C57BL/6 mice with the typical 5/6 NX exhibits normal blood pressure and well-preserved renal function. The goal of the present study is to create a new hypertensive CKD model in C57BL/6 mice. We first characterized the vascular architecture originated from each renal artery branch by confocal laser scanning microscopy with fluorescent lectin...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29412122/sodium-glucose-cotransporter-2-inhibitors-nephroprotective-impact-on-diabetic-kidney-disease
#12
Konstantinos Stavropoulos, Konstantinos Imprialos, Nikiforos Stavropoulos, Sofia Bouloukou, Georgios Kerpiniotis, Kyriakos Dimitriadis, Constantinos Tsioufis, Michael Doumas
BACKGROUND: Diabetic nephropathy is a crucial microvascular complication of diabetes mellitus that is associated with elevated cardiovascular risk. SGLT-2 inhibitors are a new class of hypoglycemic drugs that positively affect several risk factors of cardiorenal damage. OBJECTIVES: To review and critically discuss available data on the association of SGLT-2 inhibitors treatment with kidney function, progress of diabetic kidney disease, and renal related outcomes, as well to unveil potential mechanisms of action that mediate such effects...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29410236/gut-microbiota-and-probiotics-intervention-a-potential-therapeutic-target-for-management-of-cardiometabolic-disorders-and-chronic-kidney-disease
#13
REVIEW
Marinaldo Pacífico Cavalcanti Neto, Jailane de Souza Aquino, Larissa de Fátima Romão da Silva, Ruanniere de Oliveira Silva, Keyth Sulamitta de Lima Guimarães, Yohana de Oliveira, Evandro Leite de Souza, Marciane Magnani, Hubert Vidal, José Luiz de Brito Alves
The gut microbiota plays an important role in host metabolism and its dysregulation have been related to cardiometabolic disorders (CMD), such as type 2 diabetes mellitus (T2D), dyslipidemia and arterial hypertension, as well as to chronic kidney diseases (CKD). The implication of the gut microbiota on systemic disorders has been associated with changes in its composition (dysbiosis) as a result of the oxidative unbalance in the body. This alteration may be the result of the adoption of unhealthy lifestyle behavior, including lack of physical activity and fat- or sugar-rich diets, which are largely associated with increased incidence of CMD and CKD...
February 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29399021/25-hydroxyvitamin-d-levels-was-not-associated-with-blood-pressure-and-arterial-stiffness-in-patients-with-chronic-kidney-disease
#14
Kyung Mi Park, Hak Hoon Jun, Jinkun Bae, Yu Bum Choi, Dong Ho Yang, Hye Yun Jeong, Mi Jung Lee, So-Young Lee
Background: We investigated the effect of vitamin D deficiency on cardiovascular risk profiles in an Asian population with chronic kidney disease (CKD). Methods: A total of 210 participants (62 non-dialysis CKD patients and 148 hemodialysis [HD] patients) were enrolled between December 2009 and February 2010. Vitamin D deficiency was determined using the serum 25-hydroxyvitamin D [25(OH)D] concentration. Blood pressure and arterial stiffness were measured. Subjects were divided into groups according to 25(OH)D concentration based on a cut-off of 13...
December 2017: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/29398310/ethnic-disparities-in-outcomes-of-patients-with-complicated-type-b-aortic-dissection
#15
Halim Yammine, Jocelyn K Ballast, William E Anderson, John R Frederick, Charles S Briggs, Timothy Roush, Jeko M Madjarov, Tzvi Nussbaum, Joshua A Sibille, Frank R Arko
OBJECTIVE: The objective of this study was to evaluate the difference in outcomes after endovascular intervention in patients with complicated type B aortic dissection (TBAD) based on ethnicity and blood pressure control. METHODS: Between 2012 and 2016, there were 126 patients who underwent endovascular procedures for complicated TBAD at a single-institution quaternary referral center. Patients self-identified as African American (n = 53), white (n = 70), and Asian (n = 3)...
February 1, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29397598/-the-clinical-significance-of-microcirculation-and-oxygen-metabolism-evaluation-in-acute-kidney-injury-assessment-in-patients-with-septic-shock-after-resuscitation
#16
C Yu, D W Liu, X T Wang, H W He, P Pan, Z Q Xing
Objective: To evaluate the value of microcirculation and oxygen metabolism evaluation (MicrOME) in acute kidney injury(AKI) evaluation in patients with septic shock after resuscitation. Methods: Consecutive patients with septic shock after resuscitation and mechanical ventilation were enrolled from October 2016 to February 2017 in ICU at Peking Union Medical College Hospital.Patients were divided into 3 groups based on 10 min transcutaneous oxygen challenge test transcutaneous partial pressure of oxygen(PtcO(2))and venoarterial pressure of carbon dioxide difference (Pv-aCO(2)) /arteriovenous O(2) content difference (Ca-vO(2)) by blood gas analysis, i...
February 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29396103/antihypertensive-therapy-in-nondiabetic-chronic-kidney-disease-a-review-and-update
#17
REVIEW
Paul J Der Mesropian, Gulvahid Shaikh, Emmanuelle Cordero Torres, Anum Bilal, Roy O Mathew
Hypertension is an important contributor to progression of nondiabetic chronic kidney disease (CKD). Compelling observational evidence indicates that the divergence of blood pressure (BP) away from an ideal range in either direction is associated with a progressive rise in the risk of mortality and cardiovascular and renal disease progression. To date, various clinical trials and meta-analyses examining strict versus less intensive BP control in nondiabetic CKD have not conclusively demonstrated a renal advantage of one BP-lowering approach over another, except in certain subgroups such as proteinuric patients where evidence is circumstantial...
January 30, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29395334/metabolic-syndrome-but-not-obesity-measures-are-risk-factors-for-accelerated-age-related-glomerular-filtration-rate-decline-in-the-general-population
#18
Vidar T N Stefansson, Jørgen Schei, Marit D Solbu, Trond G Jenssen, Toralf Melsom, Bjørn O Eriksen
Rapid age-related glomerular filtration rate (GFR) decline increases the risk of end-stage renal disease, and a low GFR increases the risk of mortality and cardiovascular disease. High body mass index and the metabolic syndrome are well-known risk factors for patients with advanced chronic kidney disease, but their role in accelerating age-related GFR decline independent of cardiovascular disease, hypertension and diabetes is not adequately understood. We studied body mass index, waist circumference, waist-hip ratio and metabolic syndrome as risk factors for accelerated GFR decline in 1261 middle-aged people representative of the general population without diabetes, cardiovascular disease or kidney disease...
January 22, 2018: Kidney International
https://www.readbyqxmd.com/read/29395256/membrane-attack-complex-mac-deposition-in-lupus-nephritis-is-associated-with-hypertension-and-poor-clinical-response-to-treatment
#19
Shudan Wang, Ming Wu, Luis Chiriboga, Briana Zeck, H Michael Belmont
OBJECTIVE: To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment. METHODS: Immunohistochemistry was performed using unconjugated, murine anti-human complement C9 on kidney biopsies from 30 SLE patients who fulfilled 4 ACR or SLICC criteria. Clinical parameters were assessed at time of biopsy, 6 and 12 months. RESULTS: 30 renal biopsies were obtained from patients with Class II (2), III (5), IV (8), V (5), III+V (8) and IV+V (2)...
January 6, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29394983/important-decision-for-an-oral-physician-to-make-in-high-risk-chronic-kidney-disease-patients-it-is-not-only-to-recordthe-associated-resistant-hypertension-but-whether-to-use-manual-sphygmomanometer-or-automated-blood-pressure-device
#20
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