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Anna Schneider, Edda Hofstätter, Johannes Brandner, Angelika Moder, Silke Häusler, Martin Wald
BACKGROUND: Using near-infrared spectroscopy (NIRS) mixed tissue saturation can be calculated by measuring the oxygen saturation of oxygenated and deoxygenated erythrocytes in the tissue. Quality of the calculated value is not only dependent on the exposure of the measured values in the calculation, but also on external factors such as artifacts. Main object of this study was to determine whether and how the measurement quality of different devices varies in their long-term use in premature infants...
March 14, 2018: Klinische Pädiatrie
Antonio G Cabrera, Kathleen K Kibler, R Blaine Easley, Michelle Goldsworthy, Lara S Shekerdemian, Dean B Andropoulos, Jeffrey Heinle, Erin A Gottlieb, Eric Vu, Ken M Brady
BACKGROUND: Elevated arterial blood pressure (ABP) is common after superior bidirectional cavo-pulmonary anastomosis (BCPA). The effects of elevated ABP after BCPA on cerebrovascular hemodynamics are unknown. We sought to determine the relationship between elevated ABP and cerebrovascular autoregulation after BCPA. METHODS: Prospective, observational study on infants with single-ventricle physiology after BCPA surgery. Continuous recordings of mean ABP, mean cavo-pulmonary pressure (PAP), near-infrared spectroscopy measures of cerebral oximetry (rSO2), and relative cerebral blood volume index (BVI) were obtained from admission to extubation...
March 14, 2018: Pediatric Research
May W Chen, Michael Reyes, Ewa Kulikowicz, Laura Martin, David J Hackam, Raymond C Koehler, Jennifer K Lee
BACKGROUND: Abdominal near-infrared spectroscopy (aNIRS) may detect gastrointestinal hypoxia before necrotizing enterocolitis develops. We sought to validate aNIRS during splanchnic hypoxia and hypoperfusion in neonatal piglets. METHODS: Anesthetized piglets underwent systemic hypoxia or 3-h superior mesenteric artery (SMA) ligation with aNIRS monitoring. RESULTS: During progressive hypoxia, gastrointestinal tissue oxyhemoglobin saturation measured by aNIRS decreased linearly with oxyhemoglobin saturation measured directly in the portal vein...
March 14, 2018: Pediatric Research
Narin N Carmel-Neiderman, Idan Goren, Yishay Wasserstrum, Tal Frenkel Rutenberg, Irina Barbarova, Avigal Rapoport, Dor Lotan, Erez Ramaty, Naama Peltz-Sinvani, Adi Brom, Michael Kogan, Yulia Panina, Maya Rosman, Carmel Friedrich, Irina Gringauz, Amir Dagan, Iris Kliers, Tomer Ziv-Baran, Gad Segal
BACKGROUND: Accurate pulse oximetry reading at hospital admission is of utmost importance, mainly for patients presenting with hypoxemia. Nevertheless, there is no accepted or evidence-based protocol for such structured measuring. OBJECTIVES: To devise and assess a structured protocol intended to increase the accuracy of pulse oximetry measurement at hospital admission. METHODS: The authors performed a prospective comparison of protocol-based pulse-oximetry measurement with non-protocol based readings in consecutive patients at hospital admission...
March 2018: Israel Medical Association Journal: IMAJ
Ali Hariri, Junxin Wang, Yeji Kim, Anamik Jhunjhunwala, Daniel L Chao, Jesse V Jokerst
Chorioretinal imaging has a crucial role for the patients with chorioretinal vascular diseases, such as neovascular age-related macular degeneration. Imaging oxygen gradients in the eye could better diagnose and treat ocular diseases. Here, we describe the use of photoacoustic ocular imaging (PAOI) in measuring chorioretinal oxygen saturation (CR  -  sO2) gradients in New Zealand white rabbits (n  =  5) with ocular ischemia. We observed good correlation (R2  =  0.98) between pulse oximetry and PAOI as a function of different oxygen percentages in inhaled air...
March 2018: Journal of Biomedical Optics
Masatsugu Niwayama
We quantitatively investigated the measurement sensitivity of spatially resolved spectroscopy (SRS) across six tissue models: cerebral tissue, a small animal brain, the forehead of a fetus, an adult brain, forearm muscle, and thigh muscle. The optical path length in the voxel of the model was analyzed using Monte Carlo simulations. It was found that the measurement sensitivity can be represented as the product of the change in the absorption coefficient and the difference in optical path length in two states with different source-detector distances...
March 2018: Journal of Biomedical Optics
Carmelo Panetta, Sunil Rao
OBJECTIVES: Study a novel method using manual pressure on a hemostatic pad and hemoband for ulnar compression as a potential alternative for radial sheath removal. BACKGROUND: The standard for transradial access site (TRA) sheath removal requires an inflatable pressure band over the radial artery and recently a band over the ulnar artery to reduce complications. We present a novel technique using a SoftSeal®-STF hemostatic pad over the radial artery combined with a hemoband over the ulnar artery after sheath removal...
March 9, 2018: Catheterization and Cardiovascular Interventions
Marek Kawecki, Jarosław Pasek, Grzegorz Cieślar, Aleksander Sieroń, Grzegorz Knefel, Mariusz Nowak, Justyna Glik
BACKGROUND: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults. OBJECTIVES: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot. MATERIAL AND METHODS: The study included 94 patients, 30 females (32%) and 64 males (68%), aged 33-76 years, with diabetes lasting 1.5-32 years, who underwent HBOT due to diabetic foot...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Andrew C Faust, Emily Guy, Nidhu Baby, Anthony Ortegon
BACKGROUND: Methemoglobinemia is a well-recognized adverse drug reaction related to the use of certain local anesthetic agents. The mainstay of treatment for methemoglobinemia is i.v. methylene blue, along with provision of supplemental oxygen; however, methylene blue is listed as a category X teratogen. This poses an issue should methemoglobinemia develop during pregnancy. CASE REPORT: A 35-year-old, 20-week and 5-day gravid female was transferred from an outpatient oral surgeon's office for hypoxia...
March 5, 2018: Journal of Emergency Medicine
John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L Perry, Joel D Stitzel, Ashley A Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, Zeljko Vujaskovic
Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals are lacking. We hypothesized that post-exposure treatment with the lipophilic mitochondrial superoxide dismutase mimetic, MnTnHex-2-PyP5+ (hexyl), would reduce radiation-induced pneumonitis and fibrosis in the lungs of nonhuman primates...
March 7, 2018: Antioxidants (Basel, Switzerland)
Gloria Pelizzo, Anna Guddo, Aurora Puglisi, Annalisa De Silvestri, Calogero Comparato, Mario Valenza, Emanuele Bordonaro, Valeria Calcaterra
The reliability of wearable photoplethysmography (PPG) sensors to measure heart rate (HR) in hospitalized patients has only been demonstrated in adults. We evaluated the accuracy of HR monitoring with a personal fitness tracker (PFT) in children undergoing surgery. HR monitoring was performed using a wrist-worn PFT (Fitbit Charge HR) in 30 children (8.21 ± 3.09 years) undergoing laparoscopy ( n = 8) or open surgery ( n = 22). HR values were analyzed preoperatively and during surgery. The accuracy of HR recordings was compared with measurements recorded during continuous electrocardiographic (cECG) monitoring; HRs derived from continuous monitoring with pulse oximetry (SpO2R) were used as a positive control...
March 8, 2018: Children
Catherine M Ivy, Julia M York, Sabine L Lague, Beverly A Chua, Luis Alza, Kevin G McCracken, William K Milsom, Graham R Scott
Hypoxia at high altitudes constrains O2 supply to support metabolism, thermoregulation in the cold, and exercise. High-altitude natives that somehow overcome this challenge-who live, reproduce, and sometimes perform impressive feats of exercise at high altitudes-are a powerful group in which to study the evolution of physiological systems underlying hypoxia resistance. Here, we sought to determine whether a common pulse oximetry system for rodents (MouseOx Plus) can be used reliably in studies of high-altitude birds by examining the hypoxia responses of the Andean goose...
May 2018: Physiological and Biochemical Zoology: PBZ
Bushra Jalil, Valentina Hartwig, Ovidio Salvetti, Luca Potì, Luna Gargani, Tatiana Barskova, Marco Matucci Cerinic, A L'Abbate
BACKGROUND AND OBJECTIVE: Patients affected by systemic sclerosis (SSc) develop functional and structural microcirculatory dysfunction, which progressively evolves towards systemic tissue fibrosis (sclerosis). Disease initially affects distal extremities, which become preferential sites of diagnostic scrutiny. This pilot investigation tested the hypothesis that peripheral microcirculatory dysfunction in SSc could be non-invasively assessed by 2D Near Infrared Spectroscopic (NIRS) imaging of the hand associated with Vascular Occlusion Testing (VOT)...
March 2018: Computer Methods and Programs in Biomedicine
Athanasios G Kaditis, Frederic Dallaire, Jean-Paul Praud
No abstract text is available yet for this article.
March 6, 2018: Pediatric Pulmonology
Rossiana I Bojinova, Daniel F Schorderet, Christophe Valmaggia, Cengiz Türksever, Andreas Schoetzau, Margarita G Todorova
PURPOSE: Primary objective-to investigate the effect of retinal vessel oxygen saturation (SO2 ) on macular oedema (ME) in retinitis pigmentosa (RP) patients. Secondary objective-to link the presence of ME to metabolic (oxygen saturation of retinal vessels, SO2 ), functional (multifocal electroretinography, mfERG) and structural (Spectral Domain Optical Coherent Tomography, SD-OCT) alterations in RP. DESIGN: Prospective, cross-sectional, non-interventional study...
March 6, 2018: Eye
S Keisin Wang, Linden A Green, Ashley R Gutwein, Natalie A Drucker, Clifford M Babbey, Alok K Gupta, Andres Fajardo, Raghu L Motaganahalli, Michael G Wilson, Michael P Murphy
OBJECTIVE: Ethnic minorities (nonwhites) with critical limb ischemia (CLI) have historically performed worse compared with whites with regard to major amputation risk reduction and amputation-free survival (AFS) after peripheral vascular intervention. This post hoc analysis was completed to determine whether this precedent also extended to treatment of CLI without a suitable revascularization option with intramuscular injections of concentrated bone marrow aspirate (cBMA). METHODS: The treatment arm of the randomized, double-blind, multicenter MarrowStim PAD Kit for the Treatment of Critical Limb Ischemia in Subjects with Severe Peripheral Arterial Disease (MOBILE) trial was stratified by ethnicity and evaluated for demographics, comorbidities, and outcomes...
March 1, 2018: Journal of Vascular Surgery
Michael Furian, Sara E Hartmann, Tsogyal D Latshang, Deborah Flueck, Christian Murer, Philipp M Scheiwiller, Batyr Osmonov, Silvia Ulrich, Malcolm Kohler, Marc J Poulin, Konrad E Bloch
BACKGROUND: Effects of hypobaric hypoxia at altitude on exercise performance of lowlanders with chronic obstructive pulmonary disease (COPD) have not been studied in detail. OBJECTIVES: To quantify changes in exercise performance and associated physiologic responses in lowlanders with COPD travelling to moderate altitude. METHODS: A total of 31 COPD patients with a median age (quartiles) of 66 years (59; 69) and FEV1 of 56% predicted (49; 69) living below 800 m performed a constant-load bicycle exercise to exhaustion at 60% of the maximal work rate at 490 m (Zurich) and at an identical work rate at 2,590 m (Davos) in randomized order...
March 2, 2018: Respiration; International Review of Thoracic Diseases
Raúl Hidalgo Carvajal, Marcelino Sánchez Casado, Javier de Miguel-Díez, Encarnación López Gabaldón
INTRODUCTION AND OBJECTIVE: The effectiveness of home non-invasive mechanical ventilation (NIMV) is assessed by determining blood gas values in wakefulness, the evolution of their symptoms, and the monitoring of ventilation at night. The aim of our study is to evaluate whether defined values reached with outpatient monitoring by oximetry is related to the clinical, arterial gases and survival of a sample of patients with home NIMV. MATERIAL AND METHOD: Retrospective observational cohort study of a series of patients receiving home NIMV treatment for different causes...
February 28, 2018: Medicina Clínica
Maria N Plana, Javier Zamora, Gautham Suresh, Luis Fernandez-Pineda, Shakila Thangaratinam, Andrew K Ewer
BACKGROUND: Health outcomes are improved when newborn babies with critical congenital heart defects (CCHDs) are detected before acute cardiovascular collapse. The main screening tests used to identify these babies include prenatal ultrasonography and postnatal clinical examination; however, even though both of these methods are available, a significant proportion of babies are still missed. Routine pulse oximetry has been reported as an additional screening test that can potentially improve detection of CCHD...
March 1, 2018: Cochrane Database of Systematic Reviews
Angela Tedesco, Valentina Lavermicocca, Marilina Notarnicola, Luca De Francesco, Anna Rita Dellomonaco
The process of medical-healthcare technological revolution represents an advantage for the patient and for the care provider, in terms of costs and distances reduction. The telehomecare approach could be useful for monitoring the swallowing disorder in neurodegenerative diseases, preventing complications. In this study the applicability of telemedicine techniques for the monitoring of swallowing function, in patients affected by Huntington's disease (HD), was evaluated through the acquisition and analysis of the sound of swallowing...
February 2018: Recenti Progressi in Medicina
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