Jack R T Darby, Dimitra Flouri, Steven K S Cho, Georgia K Williams, Stacey L Holman, Ashley S Meakin, Michael D Wiese, Anna L David, Christopher K Macgowan, Mike Seed, Andrew Melbourne, Janna L Morrison
Increasing placental perfusion (PP) could improve outcomes of growth-restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)-5 inhibitors, which induce vasodilatation of vascular beds. We used a combination of clinically relevant magnetic resonance imaging (MRI) techniques to characterize the impact that tadalafil infusion has on maternal, placental and fetal circulations. At 116-117 days' gestational age (dGA; term, 150 days), pregnant ewes (n = 6) underwent fetal catheterization surgery...
April 12, 2024: Experimental Physiology