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Methylphenidate

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https://www.readbyqxmd.com/read/29777288/time-shifting-effects-of-methylphenidate-on-daily-rhythms-in-the-diurnal-rodent-arvicanthis-ansorgei
#1
Jorge Mendoza, Hester C van Diepen, Rob Rodrigues Pereira, Johanna H Meijer
People suffering of attention-deficit/hyperactivity disorder (ADHD) and treated with the psychostimulant methylphenidate (MPH) show sleep-wake cycle and daily rhythm alterations despite the beneficial effects of MPH on behavioral symptoms (i.e., hyperactivity, attention). In nocturnal rodents (i.e., mice), chronic exposure to MPH alters the neural activity of the circadian clock in the suprachiasmatic nucleus (SCN), behavioral rhythms, and the sleep-wake cycle. Here, we studied the effects of MPH on daily rhythms of behavior and body temperature of the diurnal rodent Arvicanthis ansorgei...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29768038/use-and-characteristics-of-antipsychotic-methylphenidate-combination-therapy-in-children-and-adolescents-with-a-diagnosis-of-attention-deficit-hyperactivity-disorder
#2
Oliver Scholle, Tobias Banaschewski, Dirk Enders, Edeltraut Garbe, Oliver Riedel
OBJECTIVE: Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) frequently have comorbidities that are potential indications for antipsychotics (APs). Some studies have suggested that the combined use of methylphenidate (MPH) and APs is increasing in this population group. Longitudinal analyses and in-depth investigations on the substance level are lacking. This study aimed to estimate the cumulative proportion of concomitant AP/MPH use in children and adolescents with ADHD over a follow-up of up to 9 years and to describe patient characteristics stratified by specific AP drug...
May 16, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29768018/psychostimulants-influence-on-body-mass-index-and-height-in-a-pediatric-population-with-attention-deficit-hyperactivity-disorder
#3
Yvette E Lentferink, Ewoudt M W van de Garde, Catherijne A J Knibbe, Marja M J van der Vorst
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is often treated with psychostimulants. Psychostimulants' adverse effects on body mass index standard deviation score (BMI-sds) and height in children/adolescents with ADHD have been reported. However, literature is inconsistent, and it is unclear whether the observed effects are dosage- and/or BMI-dependent. Therefore, the aim of this retrospective observational study is to evaluate the influence of psychostimulants on BMI-sds and height-sds in a pediatric cohort with ADHD from an outpatient clinic, and to study the correlation between psychostimulant dosage and BMI-sds and height-sds change...
May 16, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29765401/mixed-effects-modeling-of-neurofeedback-self-regulation-performance-moderators-for-learning-in-children-with-adhd
#4
Agnieszka Zuberer, Franziska Minder, Daniel Brandeis, Renate Drechsler
Introduction: Neurofeedback (NF) has gained increasing popularity as a training method for children and adults with attention deficit hyperactivity disorder (ADHD). However, it is unclear to what extent children learn to regulate their brain activity and in what way NF learning may be affected by subject- and treatment-related factors. Methods: In total, 48 subjects with ADHD (age 8.5-16.5 years; 16 subjects on methylphenidate (MPH)) underwent 15 double training sessions of NF in either a clinical or a school setting...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29765219/estimated-prevalence-and-incidence-of-diagnosed-adhd-and-health-care-utilization-in-adults-in-sweden-a-longitudinal-population-based-register-study
#5
Maria Polyzoi, Ewa Ahnemark, Emma Medin, Ylva Ginsberg
Background: Although the worldwide prevalence of attention-deficit/hyperactivity disorder (ADHD) in adults is estimated to be between 2% and 5%, it is considered to be underdiagnosed. This register study explored the prevalence of diagnosed ADHD and incidence of newly diagnosed ADHD in Swedish adults over time, and assessed comorbidities and pharmacologic treatment. Methods: National Patient Register data were used to estimate the overall prevalence of adults (≥18 years) with a registered ADHD diagnosis from 2006 to 2011, and the incidence of newly registered diagnoses from 2007 to 2011...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29756534/neurostimulant-prescribing-patterns-in-children-admitted-to-the-icu-after-traumatic-brain-injury
#6
Amanda Marie Morrison, Amy Houtrow, James Zullo, Patrick M Kochanek, Carol Vetterly, Ericka L Fink
Neurostimulant medications are commonly prescribed following traumatic brain injury (TBI) in adults; little is known about their use in children with TBI. Our objective was to analyze neurostimulant prescribing practices from 2005 to 2015 in children admitted to the intensive care unit (ICU) with TBI. We hypothesized that neurostimulant prescriptions have increased over time and are associated with older age and injury severity. A retrospective cohort study of patients aged 1 month to 18 years with an ICD-9-CM discharge diagnosis code for TBI admitted to the ICU between 2005 and 2015 in 37 pediatric hospitals included in the Pediatric Health Information System was conducted...
May 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29756071/improving-the-quality-of-physical-health-monitoring-in-camhs-for-children-and-adolescents-prescribed-medication-for-adhd
#7
Cristal Oxley, Omer S Moghraby, Rani Samuel, Dan W Joyce
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterised by a persistent, pervasive pattern of inattention, impulsivity and hyperactivity. Stimulant medication such as methylphenidate has an established evidence base in the treatment of children and adolescents with ADHD. However, it is also associated with a risk of side effects which may include decreased appetite, increased blood pressure and possible reduced growth. Monitoring physical health in children and adolescents prescribed medication for ADHD is a key clinical responsibility and includes a number of parameters as outlined in the National Institute for Health and Care Excellence Guidelines...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29751051/neurocognitive-effects-of-methylphenidate-in-adults-with-attention-deficit-hyperactivity-disorder-a-meta-analysis
#8
REVIEW
Michelle A Pievsky, Robert E McGrath
PIEVSKY, M. A., and R. E. McGrath. Neurocognitive effects of methylphenidate in adults with attention-deficit/hyperactivity disorder: A meta-analysis…NEUROSCI BIOBEHAV REV 81(1) XXX-XXX, 2017.- This meta-analysis summarized 21 double-blind randomized controlled trials with a mean study duration of 18 days comparing the neurocognitive functioning of adults with attention-deficit/hyperactivity disorder (ADHD) on methylphenidate vs placebo. Effect sizes were weighted using a random-effects model. Scores on neurocognitive measures and tests of driving ability were on average higher on methylphenidate than on placebo, g = ...
May 8, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29750737/inter-and-intraindividual-variation-of-methylphenidate-concentrations-in-serum-and-saliva-of-patients-with-attention-deficit-hyperactivity-disorder
#9
Joshua Preiskorn, Sophie Studer, Reinhold Rauh, Richard Lukačin, Christoph Geffert, Christian Fleischhaker, Hans-Willi Clement, Eberhard Schulz, Monica Biscaldi
BackgroundTherapeutic drug monitoring (TDM) is becoming increasingly important in psychiatric therapy; especially in children. However, for several reasons, it cannot yet be implemented as a daily routine in clinical or outpatient settings. To evaluate new, non-invasive procedures; blood and saliva (oral fluid) samples were collected from patients with attention-deficit/hyperactivity disorder (ADHD) who were also being administered methylphenidate (MPH). The study's main purposes were to correlate MPH concentrations in serum and saliva between subjects; and to analyze intraindividual variation of serum concentration...
May 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29744873/methylphenidate-for-attention-deficit-hyperactivity-disorder-adhd-in-children-and-adolescents-assessment-of-adverse-events-in-non-randomised-studies
#10
REVIEW
Ole Jakob Storebø, Nadia Pedersen, Erica Ramstad, Maja Lærke Kielsholm, Signe Sofie Nielsen, Helle B Krogh, Carlos R Moreira-Maia, Frederik L Magnusson, Mathilde Holmskov, Trine Gerner, Maria Skoog, Susanne Rosendal, Camilla Groth, Donna Gillies, Kirsten Buch Rasmussen, Dorothy Gauci, Morris Zwi, Richard Kirubakaran, Sasja J Håkonsen, Lise Aagaard, Erik Simonsen, Christian Gluud
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. The psychostimulant methylphenidate is the most frequently used medication to treat it. Several studies have investigated the benefits of methylphenidate, showing possible favourable effects on ADHD symptoms, but the true magnitude of the effect is unknown. Concerning adverse events associated with the treatment, our systematic review of randomised clinical trials (RCTs) demonstrated no increase in serious adverse events, but a high proportion of participants suffered a range of non-serious adverse events...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29739137/methylphenidate-induced-lip-and-tongue-biting
#11
Cem Gokcen, Mehmet Karadag, Ihsan Aksoy
Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD and they have various side effects. Herein, we report a case who bit off the tip of her tongue with Osmotic Release Oral System methylphenidate (OROS MPH) 36 mg/day, bit the tip of her lower lip with immediate release (IR) MPH 10 mg/day and lateral part of her tongue with IR MPH 20 mg/day...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29738277/methylphenidate-mediated-motor-control-network-enhancement-in-patients-with-traumatic-brain-injury
#12
Charlie L Dorer, Anne E Manktelow, Judith Allanson, Barbara J Sahakian, John D Pickard, Andrew Bateman, David K Menon, Emmanuel A Stamatakis
PRIMARY OBJECTIVE: To investigate functional improvement late (>6 months) after traumatic brain injury (TBI). To this end, we conducted a double-blind, placebo-controlled experimental medicine study to test the hypothesis that a widely used cognitive enhancer would benefit patients with TBI. RESEARCH DESIGN: We focused on motor control function using a sequential finger opposition fMRI paradigm in both patients and age-matched controls. METHODS AND PROCEDURES: Patients' fMRI and DTI scans were obtained after randomised administration of methylphenidate or placebo...
May 8, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29736089/hair-loss-due-to-methylphenidate-use-a-case-study
#13
Öznur Bilaç, Meryem Özlem Kütük, Cemal Bilaç
No abstract text is available yet for this article.
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29733106/how-do-stimulant-treatments-for-adhd-work-evidence-for-mediation-by-improved-cognition
#14
Larry W Hawk, Whitney D Fosco, Craig R Colder, James G Waxmonsky, William E Pelham, Keri S Rosch
BACKGROUND: Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). Despite their well-documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning. METHODS: Children with ADHD (n = 82; 9-12 years old) participated in a week-long summer research camp, consisting of cognitive testing, classroom periods, and recreational activities...
May 7, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29727467/pharmacological-interventions-for-apathy-in-alzheimer-s-disease
#15
REVIEW
Myuri T Ruthirakuhan, Nathan Herrmann, Eleenor H Abraham, Sarah Chan, Krista L Lanctôt
BACKGROUND: Despite the high prevalence of apathy in Alzheimer's disease (AD), and its harmful effects, there are currently no therapies proven to treat this symptom. Recently, a number of pharmacological therapies have been investigated as potential treatments for apathy in AD. OBJECTIVES: Objective 1: To assess the safety and efficacy of pharmacotherapies for the treatment of apathy in Alzheimer's disease (AD).Objective 2: To assess the effect on apathy of pharmacotherapies investigated for other primary outcomes in the treatment of AD...
May 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29719440/pharmacologic-interventions-for-fatigue-in-cancer-and-transplantation-a-meta-analysis
#16
REVIEW
D Tomlinson, P D Robinson, S Oberoi, D Cataudella, N Culos-Reed, H Davis, N Duong, F Gibson, M Götte, P Hinds, S L Nijhof, P van der Torre, S Cabral, L L Dupuis, L Sung
Background: Our objective was to determine whether, compared with control interventions, pharmacologic interventions reduce the severity of fatigue in patients with cancer or recipients of hematopoietic stem-cell transplantation (hsct). Methods: For a systematic review, we searched medline, embase, the Cochrane Central Register of Controlled Trials, cinahl, and Psychinfo for randomized trials of systemic pharmacologic interventions for the management of fatigue in patients with cancer or recipients of hsct...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29716850/methylphenidate-induced-hepatotoxicity-in-rats-and-its-reduction-by-buspirone
#17
Nausheen Alam, Rahila Ikram
Methylphenidate is commonly use for the treatment of attention deficit hyperactivity disorder (ADHD), but its long term use was found to produce hepatic necrosis in mice. Purpose of this study was to investigate that co-administration of buspirone (drug which attenuates methylphenidate induced sensitization) may attenuate methylphenidate-induced hepatotoxic effects and to determine the effect of challenge dose of haloperidol (D2 antagonist that blocks the effects of methylphenidate in case of intoxication) on SGPT and SGOT levels in methylphenidate treated rats...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29708762/improvements-in-irritability-with-open-label-methylphenidate-treatment-in-youth-with-comorbid-attention-deficit-hyperactivity-disorder-and-disruptive-mood-dysregulation-disorder
#18
Drew E Winters, Sadaaki Fukui, Ellen Leibenluft, Leslie A Hulvershorn
OBJECTIVE: The purpose of this open-label study was to examine the effects of long-acting methylphenidate (MPH) treatment on irritability and related emotional symptoms associated with disruptive mood dysregulation disorder (DMDD) in youth with comorbid attention-deficit/hyperactivity disorder (ADHD). METHODS: The sample included 22 medication-free male and female subjects (ages 9-15) who met criteria for both DMDD and ADHD. Participants underwent a 4-week trial of long-acting MPH treatment (Concerta® ), with weekly dosing increases until a therapeutic dose was reached...
April 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29704983/intermittent-stimulation-in-the-nucleus-basalis-of-meynert-improves-sustained-attention-in-rhesus-monkeys
#19
Ruifeng Liu, Jonathan Crawford, Patrick M Callahan, Alvin V Terry, Christos Constantinidis, David T Blake
Sustained attention is essential in important behaviors in daily life. Many neuropsychiatric disorders are characterized by a compromised ability to sustain attention, making this cognitive domain an important therapeutic target. In this study, we tested a novel method of improving sustained attention. Monkeys were engaged in a continuous performance task (CPT) while the nucleus basalis of Meynert (NB), the main source of cholinergic innervation of the neocortex, was stimulated. Intermittent NB stimulation improved the animals' performance by increasing the hit rate and decreasing the false alarm rate...
April 26, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29703446/adding-methylphenidate-to-prism-adaptation-improves-outcome-in-neglect-patients-a-randomized-clinical-trial
#20
Jacques Luauté, Laurent Villeneuve, Adeline Roux, Stuart Nash, Jean-Yves Bar, Eric Chabanat, François Cotton, Sophie Ciancia, Pierre-Olivier Sancho, Patrick Hovantruc, François Quelard, Thierry Sarraf, Yann Cojan, Fadila Hadj-Bouziane, Alessandro Farné, Audrey Janoly-Dumenil, Dominique Boisson, Sophie Jacquin-Courtois, Gilles Rode, Yves Rossetti
Spatial neglect is one of the main predictors of poor functional recovery after stroke. Many therapeutic interventions have been developed to alleviate this condition, but to date the evidence of their effectiveness is still scarce. OBJECTIVE: The purpose of this study was to test whether combining prism adaptation (PA) and methylphenidate (MP) could enhance the recovery of neglect patients at a functional level. METHODS: RITAPRISM is a multicentre, randomized, double-blind, placebo-controlled study comparing PA plus placebo (control) versus PA plus MP...
April 4, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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