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Methylphenidate

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https://www.readbyqxmd.com/read/28925314/effect-of-methylphenidate-on-visual-responses-in-the-superior-colliculus-in-the-anaesthetised-rat-role-of-cortical-activation
#1
L Hetherington, E J Dommett, A C Turner, T B Riley, J X Haensel, P G Overton
The mechanism of action of psychostimulant drugs in the treatment of Attention Deficit Hyperactivity Disorder is still largely unknown, although recent evidence suggests one possibility is that the drugs affect the superior colliculus (SC). We have previously demonstrated that systemically administered d-amphetamine attenuates/abolishes visual responses to wholefield light flashes in the superficial layers of the SC in anaesthetised rats, and the present study sought to extend this work to methylphenidate (MPH)...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28922707/accidental-intra-arterial-injection-of-methylphenidate-into-the-radial-artery
#2
Michael Pannett, Katherine Goodall, Sherab Bhutia
No abstract text is available yet for this article.
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28920083/differential-alterations-of-intracellular-ca-2-dynamics-induced-by-cocaine-and-methylphenidate-in-thalamocortical-ventrobasal-neurons
#3
José L Rozas, Belén Goitia, Verónica Bisagno, Francisco J Urbano
The ventrobasal (VB) thalamus relay nucleus processes information from rodents' whiskers, projecting to somatosensory cortex. Cocaine and methylphenidate (MPH) have been described to differentially alter intrinsic properties of, and spontaneous GABAergic input to, VB neurons. Here we studied using bis-fura 2 ratiometric fluorescence the effects of cocaine and MPH on intracellular [Ca(2+)] dynamics at the soma and dendrites of VB neurons. Cocaine increased baseline fluorescence in VB somatic and dendritic compartments...
July 2017: Translational Brain Rhythmicity
https://www.readbyqxmd.com/read/28914218/-apathetic-geriatric-patient-benefits-from-methylphenidate
#4
A Ter Keurst, J H A M Tuerlings, E A Bertholet, H W Wijnen
Two independent, home-dwelling geriatric patients presented with apathy at a general practice in the Netherlands and were seen by an elderly care physician after (non-)medical interventions had failed. Both patients were treated with low-dose methylphenidate. During treatment, apathy symptoms decreased and the patients became more active. Apathy is a frequent symptom of several neuropsychiatric diseases, depression and somatic conditions. Its incidence varies from 1.3% in healthy elderly people to more than 50% in the elderly with depression or dementia...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28900353/brain-doping-stimulants-use-and-misuse-among-a-sample-of-italian-college-students
#5
REVIEW
S Majori, D Gazzani, S Pilati, J Paiano, A Sannino, S Ferrari, E Checchin
INTRODUCTION: The non-medical use of prescription stimulants (NMUPS) has become the subject of great interest for its diffusion among university students, who abuse these substances to cope with the increasing load of academic stress. NMUPS has been widely investigated in the U.S. due to its increasing trend; this behavior, however, has also been reported in Europe. The aim of this cross-sectional study was to examine stimulants misuse in a Northern Italian geographic area, identifying possible developments of the phenomenon in Italy...
June 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28899641/attention-deficit-hyperactivity-disorder-medication-use-in-adolescents-the-patient-s-perspective
#6
Richelle C Kosse, Marcel L Bouvy, Daphne Philbert, Tjalling W de Vries, Ellen S Koster
PURPOSE: The purpose of the study was to gain more insight into the attitudes of adolescents using medication for attention-deficit/hyperactivity disorder (ADHD). METHODS: A cross-sectional study among adolescents (aged 12-18 years) who filled at least two prescriptions for ADHD medication in the preceding year was conducted. Adolescents were invited to fill in an online questionnaire containing questions on sociodemographics, health status, illness perceptions, medication adherence, and medication beliefs...
September 9, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28893054/effect-of-methylphenidate-on-orthodontic-tooth-movement-and-histological-features-of-bone-tissue-in-rats-an-experimental-study
#7
Hossein Aghili, Soghra Yassaei, Shokouh Taghipour Zahir, Rahele Arjmandi
INTRODUCTION: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. AIM: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. MATERIALS AND METHODS: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28885263/the-use-of-methylphenidate-to-relieve-fatigue
#8
Rocío Rojí, Carlos Centeno
PURPOSE OF REVIEW: To review recent evidence on the efficacy and safety of methylphenidate as a symptomatic treatment of patients with cancer-related fatigue (CRF). RECENT FINDINGS: Five clinical trials published since 2011 were identified. Two of these concluded that methylphenidate is more efficacious than placebo in providing relief from CRF, but the remaining three showed no difference in favour of methylphenidate. The studies were heterogeneous as per the dosage, scales used for evaluating fatigue and the target group studied...
September 6, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28885224/impaired-reproduction-after-exposure-to-adhd-drugs-systematic-review-of-animal-studies
#9
Pia Brandt Danborg, Anders Lykkemark Simonsen, Peter C Gøtzsche
BACKGROUND: Few studies have reported on long-term harms caused by ADHD drugs but they are known to impair growth. OBJECTIVE: To assess whether ADHD drugs impair reproduction in mammals. METHODS: Systematic review of reproduction in studies of animals treated with ADHD drugs. DATA SOURCES: PubMed, Biosis and EMBASE. RESULTS: We included 17 studies. The studies were generally of poor quality or poorly reported...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28871191/pharmacogenetics-of-methylphenidate-in-childhood-attention-deficit-hyperactivity-disorder-long-term-effects
#10
Clara I Gomez-Sanchez, Juan J Carballo, Rosa Riveiro-Alvarez, Victor Soto-Insuga, Maria Rodrigo, Ignacio Mahillo-Fernandez, Francisco Abad-Santos, Rafael Dal-Ré, Carmen Ayuso
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in which a significant proportion of patients do not respond to treatment. The objective of this study was to examine the role of genetic risk variants in the response to treatment with methylphenidate (MPH). The effectiveness of MPH was evaluated based on variations in the CGI-S and CGAS scales over a 12-month treatment period using linear mixed effects models. A total of 208 ADHD patients and 34 polymorphisms were included in the analysis...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868642/assessing-risk-of-bias-in-randomized-controlled-trials-of-methylphenidate-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-adhd
#11
Raíssa Rodrigues-Tartari, Walter Swardfager, Giovanni A Salum, Luís A Rohde, Hugo Cogo-Moreira
To test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled "Methylphenidate for children and adolescents with attention deficit hyperactivity disorder...
September 4, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28866005/discrete-memory-impairments-in-largely-pure-chronic-users-of-mdma
#12
Michael D Wunderli, Matthias Vonmoos, Marina Fürst, Katrin Schädelin, Thomas Kraemer, Markus R Baumgartner, Erich Seifritz, Boris B Quednow
Chronic use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") has repeatedly been associated with deficits in working memory, declarative memory, and executive functions. However, previous findings regarding working memory and executive function are inconclusive yet, as in most studies concomitant stimulant use, which is known to affect these functions, was not adequately controlled for. Therefore, we compared the cognitive performance of 26 stimulant-free and largely pure (primary) MDMA users, 25 stimulant-using polydrug MDMA users, and 56 MDMA/stimulant-naïve controls by applying a comprehensive neuropsychological test battery...
August 30, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28864865/the-effect-of-single-dose-methylphenidate-on-the-rate-of-error-driven-learning-in-healthy-males-a-randomized-controlled-trial
#13
Jonathon R Howlett, He Huang, Cédric M Hysek, Martin P Paulus
RATIONALE AND OBJECTIVES: Norepinephrine mediates the adjustment of error-driven learning to match the rate of change of the environment, while phasic dopamine signals prediction errors. We tested the hypothesis that pharmacologic manipulation may modulate this process. METHODS: We administered a single dose of methylphenidate, a norepinephrine/dopamine reuptake inhibitor, or placebo in double-blind randomized fashion to 20 healthy human males, who then performed a probabilistic learning task...
September 1, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28861338/increased-default-mode-variability-is-related-to-reduced-task-performance-and-is-evident-in-adults-with-adhd
#14
Athanasia M Mowinckel, Dag Alnæs, Mads L Pedersen, Sigurd Ziegler, Mats Fredriksen, Tobias Kaufmann, Edmund Sonuga-Barke, Tor Endestad, Lars T Westlye, Guido Biele
Insufficient suppression and connectivity of the default mode network (DMN) is a potential mediator of cognitive dysfunctions across various disorders, including attention deficit/hyperactivity disorder (ADHD). However, it remains unclear if alterations in sustained DMN suppression, variability and connectivity during prolonged cognitive engagement are implicated in adult ADHD pathophysiology, and to which degree methylphenidate (MPH) remediates any DMN abnormalities. This randomized, double-blinded, placebo-controlled, cross-over clinical trial of MPH (clinicaltrials...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28856464/dosage-of-methylphenidate-and-traumatic-brain-injury-in-adhd-a-population-based-study-in-taiwan
#15
Yin-To Liao, Yao-Hsu Yang, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Tsu-Nai Wang, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
Preventive effect of stimulants on the risk of brain injuries had been reported. The aim of this study is to determine the extent to which methylphenidate (MPH) prescription moderates the risk of traumatic brain injuries (TBI) in individuals with attention-deficit/hyperactivity disorder (ADHD). Individuals with a recent diagnosis of ADHD between January 1997 and December 2013 (n = 163,618) were identified from Taiwan's National Health Insurance Research Database. A total of 124,438 adolescents and children with ADHD and without prior TBI diagnoses were included and evaluated for subsequent TBI...
August 30, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28855123/biotransformation-of-ritalinic-acid-by-laccase-in-the-presence-of-mediator-tempo
#16
Aza Kobakhidze, Vladimir Elisashvili, Philippe F-X Corvini, Monika Čvančarová
Methylphenidate is widely used as a medication for the treatment of attention deficit hyperactivity disorder (ADHD) in children. Less than 1% of methylphenidate is excreted unchanged in urine, while 80% of an oral dose is excreted as ritalinic acid (which is reportedly poorly degradable). This study aims to investigate the biotransformation of ritalinic acid by free and immobilized enzymes. The influence of various laccase mediators on biotransformation efficiency has been tested. Formation of the main transformation products has been monitored and their potential structures suggested...
August 27, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28855122/bacterial-isolates-degrading-ritalinic-acid-human-metabolite-of-neuro-enhancer-methylphenidate
#17
Marta Woźniak-Karczewska, Monika Čvančarová, Łukasz Chrzanowski, Philippe F-X Corvini, Danuta Cichocka
The consumption of nootropic drugs has increased tremendously in the last decade, though the studies on their environmental fate are still scarce. Nootropics are bioactive compounds designed to alter human's physiology therefore the adverse effects towards wildlife can be expected. In order to understand their environmental impact, the knowledge on their transformation pathways is necessary. Methylphenidate belongs to the most prescribed neuro-enhancers and is among the most favored smart drugs used in non-medical situations...
August 27, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28837827/pharmacotherapy-of-emotional-dysregulation-in-adults-with-adhd-a-systematic-review-and-meta-analysis
#18
REVIEW
Francesca Lenzi, Samuele Cortese, Joseph Harris, Gabriele Masi
Emotional dysregulation (ED) is a dysfunction in modifying an emotional state in an adaptive and goal oriented way, with excitability, ease anger, and mood lability. It is present in up to 70% of adults with ADHD, regardless of other comorbidities, and substantially worsens the psychosocial outcomes of the disorder. Besides fronto-parietal circuits mediating top-down control, brain regions involved in bottom-up processes (e.g., amygdala, orbitofrontal cortex, and ventral striatum) are implicated in ED. We performed a systematic review/meta-analysis of double-blind randomized controlled trials of ADHD medications to assess their effects on ED in adults with ADHD...
August 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28836895/correlations-between-clinical-trial-outcomes-based-on-symptoms-functional-impairments-and-quality-of-life-in-children-and-adolescents-with-adhd
#19
David R Coghill, Alain Joseph, Vanja Sikirica, Mark Kosinski, Caleb Bliss, Michael Huss
OBJECTIVE: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. METHOD: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference)...
August 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28817309/weight-height-and-body-mass-index-in-patients-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate
#20
Azucena Díez-Suárez, María Vallejo-Valdivielso, Juan J Marín-Méndez, Pilar de Castro-Manglano, César A Soutullo
OBJECTIVE: To describe the methylphenidate (MPH) effects on weight, height, and body mass index (BMI) in a Spanish sample diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHODS: Patients (6-18 years) diagnosed with ADHD treated at our Unit with MPH in the last 10 years were included in an observational longitudinal study. Weight, height, and BMI Z scores were measured at baseline and at last follow-up. RESULTS: Three hundred forty-two patients (mean [standard deviation] age: 10...
August 17, 2017: Journal of Child and Adolescent Psychopharmacology
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