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Yukitoshi Sakao, Mitsushige Sugimoto, Hitomi Ichikawa, Shu Sahara, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Yoshihide Fujigaki, Ken Sugimoto, Takahisa Furuta, Tadashi Sakao, Hideo Yasuda
BACKGROUND: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy and Helicobacter pylori status. METHODS: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by gastroduodenoscopy and for H...
2016: American Journal of Nephrology
Vishal Sharma, Arvind Ahuja
An 18-year-old woman presented with recurrent episodes of diarrhea associated with epigastric discomfort and bloating. Examination of the stool revealed trophozoites of the species Giardia lamblia. She underwent gastroduodenoscopy, which revealed numerous nodules in the duodenum (Panel A). Multiple..
July 21, 2016: New England Journal of Medicine
Ujjwal Sonika, Pooja Goswami, Bhaskar Thakur, Rajni Yadav, Prasenjit Das, Vineet Ahuja, Anoop Saraya
BACKGROUND AND AIMS: Intestinal permeability (IP) has been shown to be increased in acute pancreatitis (AP) and is considered to be responsible for development of septic complications. However, the mechanism of increase in IP is not well studied. We studied whether alteration in tight junction proteins (TJP) has any role in altered IP in patients with AP. MATERIALS AND METHODS: This is a prospective study conducted at a tertiary care referral center. Twenty consecutive moderate and severe AP patients fulfilling the study criteria were included along with 20 controls that underwent gastroduodenoscopy for dyspepsia...
July 25, 2016: Journal of Clinical Gastroenterology
Jean-Philippe Drouin-Chartier, André J Tremblay, Valéry Lemelin, Marie-Claude Lépine, Benoît Lamarche, Patrick Couture
AIM: The objective of the present study was to gain further insight into intestinal cholesterol homeostasis in dyslipidemic men with insulin resistance (IR) by examining the impact of treatment with ezetimibe on the expression of key genes involved in cholesterol synthesis and LDL receptor (R)-mediated uptake of lipoproteins. METHODS: Twenty-five men with dyslipidemia and IR were recruited to participate in this double-blinded, randomized, cross-over, placebo-controlled trial...
July 27, 2016: Diabetes, Obesity & Metabolism
Dinesh Zirpe, Majid Wani, Priyanka Tiwari, Palaniswamy Kalipatti Ramaswamy, Reddy Prasanna Kumar
Lipomas of the gastrointestinal tract are rare. Duodenal lipomas are incidental and mostly asymptomatic. Tumours may produce symptoms of abdominal pain and discomfort or cause bleeding due to ulceration or intestinal obstruction due to intussusception. We describe a 45-year-old man presenting in emergency with 3 days history of melena with normal gastroduodenoscopy and contrast enhanced computed tomography revealing multiple polypoid lesion in duodenum and proximal jejunum suggestive of lipoma. Due to ongoing bleed, he underwent laparotomy with duodenectomy and uneventful postoperative recovery...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
M Sharman, B Bacci, K Simpson, C Mansfield
Intracellular colonisation may serve as a protected niche where Helicobacter spp. organisms evade effective treatment. In dogs, non-Helicobacter pylori-helicobacters are frequently intracellular. Confocal endomicroscopy allows in vivo gastrointestinal imaging and has aided real-time identification of Helicobacter pylori and other intracellular and mucosally associated bacteria. The objectives of this study were: (1) to determine the utility of confocal endomicroscopy to identify non-Helicobacter pylori-helicobacters compared with other diagnostic modalities, and (2) to assess its ability to identify intracellular organisms...
July 2016: Veterinary Journal
Keitaro Takahashi, Takahiro Ito, Tomonobu Sato, Mitsuru Goto, Toru Kawamoto, Akihiro Fujinaga, Nobuyuki Yanagawa, Yoshinori Saito, Minoru Nakao, Hideo Hasegawa, Mikihiro Fujiya
Corynosoma is a parasite that can normally be found in the intestinal tract of fish-eating mammals, particularly in seals and birds. The present case proposed that Corynosoma could attain full maturity in the human intestine. A 70-year-old female complained of abdominal pain. A computed tomography (CT) scan revealed a swelling of the intraperitoneal lymph nodes with no responsible lesion. Video capsule endoscopy and double-balloon endoscopy detected several ulcerations and one parasite in the ileum, which was tightly attached at the bottom of the ulcerations...
June 2016: Clinical Journal of Gastroenterology
Kanefumi Yamashita, Shinsuke Takeno, Satoshi Nimura, Yoshikazu Sugiyama, Takayuki Sueta, Kenji Maki, Yoshiyuki Kayashima, Hironari Shiwaku, Daisuke Kato, Tatsuya Hashimoto, Takamitsu Sasaki, Yuichi Yamashita
INTRODUCTION: We present a very rare case of gastric metastasis mimicking primary gastric cancer in a patient who had undergone surgery for salivary duct carcinoma. PRESENTATION OF CASE: A 67-year-old man had been diagnosed as having right parotid cancer and had undergone a right parotidectomy and lymph node dissection. The histological diagnosis was salivary duct carcinoma. One year after the surgery, a positron emission tomography-computed tomography scan using fluorodeoxyglucose (FDG) revealed an abnormal uptake of FDG in the left cervical, mediastinal, paraaortic, and cardiac lymph nodes; stomach; and pancreas...
2016: International Journal of Surgery Case Reports
Xin-Yi Mao, Shun-Fu Xu, Qing Liu, Jian-Xia Jiang, Hai-Han Zhang, Huai-Ming Sang, Guo-Xin Zhang
BACKGROUND/AIMS: Gastric intestinal metaplasia (IM) is an important risk factor for intestinal-type gastric carcinoma, and successful treatment critically depends on its timely detection. In order to guide appropriate endoscopic surveillance, objective knowledge on the anatomical predilection of intestinal metaplasia development is urgently needed. MATERIALS AND METHODS: A total of 78,335 cases who underwent gastroduodenoscopy from 2008 to 2013 in Jiangsu and Anhui provinces in China, were studied...
March 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Ryuichi Yamamoto, Shingo Kato, Toshinori Maru, Riki Ninomiya, Fumiaki Ozawa, Yoshifumi Beck, Keiko Abe, Jun-Ichi Tamaru, Sumiko Nagoshi, Koji Yakabi
We herein describe a case of somatostatinoma coexisting with a gastrointestinal stromal tumor (GIST) in the duodenum of an 81-year-old woman with Von Recklinghausen's disease (VRD) and common bile duct stone who presented with diarrhea of three months in duration. Gastroduodenoscopy revealed an ulcer on the second part of the duodenum. A 2.1-cm enhancing tumor was observed to extend from the ulcer on an abdominal computed tomography scan. Subtotal stomach-preserving pancreaticoduodenectomy revealed a somatostatinoma on the papilla of the vater and duodenal GIST...
2016: Internal Medicine
Marye J Boers-Sonderen, Sasja F Mulder, Iris D Nagtegaal, Lauranne A A P Derikx, Geert J A Wanten, Peter F A Mulders, Winette T A van der Graaf, Frank Hoentjen, Carla M L van Herpen
BACKGROUND: Diarrhea is a frequently occurring adverse event during treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR TKIs) and is mostly accompanied by abdominal cramps, flatulence and pyrosis. These complaints impair quality of life and lead to dose reductions and treatment interruptions. It is hypothesized that the diarrhea might be due to ischemia in bowel mucosa or inflammation, but the exact underlying pathophysiological mechanism of the diarrhea is still unknown...
2016: Acta Oncologica
Shuji Komori, Masahiko Kawai, Toyoo Nitta, Yusuke Murase, Keita Matsumoto, Chika Shinoda, Masashi Kuno, Yuki Sasaguri, Masahiro Fukada, Yoshimi Asano, Shigeru Kiyama, Chihiro Tanaka, Yasuko Nagao, Narutoshi Nagao, Katsuyuki Kunieda
BACKGROUND: Carcinoma and adenoma of the duodenum, including the papilla of Vater, are problematic diseases in patients with familial adenomatous polyposis (FAP). CASE PRESENTATION: A 36-year-old man underwent a periodic medical examination for early colon cancer originating from FAP for which laparoscopic-assisted subtotal colectomy with a J-shaped ileal pouch-rectal anastomosis was performed 3 years earlier. A tumor was detected at the papilla of Vater along with elevation of total bilirubin and hepatobiliary enzymes...
2016: World Journal of Surgical Oncology
Gee Young Yun, Woo Sub Kim, Hye Jin Kim, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong
The incidence of gastric band erosion has decreased to 1%. Gastric band erosion can manifest with various clinical symptoms, although some patients remain asymptomatic. We present a case of a mostly asymptomatic patient who was diagnosed with gastric band erosion during a routine health check-up. A 32-year-old man without any underlying diseases except for non-alcoholic fatty liver underwent laparoscopic adjustable gastric band surgery in 2010. He had no significant complications postoperatively. He underwent routine health check-ups with near-normal gastroduodenoscopic findings through 2014...
May 2016: Clinical Endoscopy
Yuichiro Watanabe, Hiroyuki Baba, Jun Sobajima, Minoru Fukuchi, Youichi Kumagai, Keiichiro Ishibashi, Erito Mochiki, Hideki Ishikawa, Hideyuki Ishida
INTRODUCTION: Reports on pancreas-preserving total duodenectomy (PPTD) for duodenal polyposis (DP) in familial adenomatous polyposis (FAP) patients are rare. We herein report a case of PPTD performed by minilaparotomy for DP in an FAP patient. CASE: A 27-year-old female FAP patient was diagnosed with Spigelman classification (SC) stage Ⅳ DP on gastroduodenoscopy. She underwent PPTD through a 7 cm upper abdominal incision. All polyps were confirmed as adenomas histopathologically...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Sun Ju Chung, Juyeon Kim, Hyo Jeong Lee, Ho-Sung Ryu, Kiju Kim, Jeong Hoon Lee, Kee Wook Jung, Mi Jung Kim, Mi-Jung Kim, Young Jin Kim, Sung-Cheol Yun, Joo-Yong Lee, Seung-Mo Hong, Seung-Jae Myung
BACKGROUND: Gastric and colonic alpha-synuclein immunoreactivity has been reported in patients with Parkinson's disease (PD). However, enteric alpha-synuclein also has been reported in healthy individuals. OBJECTIVES: We aimed to investigate the utility of alpha-synuclein immunoreactivity from gastric and colonic mucosal tissues obtained by routine endoscopy to detect PD, and to correlate the pathological burden of alpha-synuclein with motor and nonmotor features of PD...
February 2016: Movement Disorders: Official Journal of the Movement Disorder Society
M E Grasman, A M Pettersson, A Catsburg, A G Koek, A A van Bodegraven, P H M Savelkoul
Mucosal biopsy samples from individuals not suspected of having Whipple's disease were tested for the presence of Tropheryma whipplei. A sensitive and specific real-time PCR assay targeting a sequence present seven times in the T. whipplei genome was used. T. whipplei DNA was detected in 2.0 and 3.8% of the patients undergoing gastroduodenoscopy and colonoscopy, respectively, who were tested.
December 2015: Journal of Clinical Microbiology
Yoshiaki Isono, Youichirou Baba, Tomonori Saito, Hiroaki Kumazawa, Hiroki Tanaka, Shimpei Matsusaki, Tomohiro Sase, Hiroshi Okano, Katsumi Mukai
A 73-year-old man with a history of tarry stools was admitted to our hospital. Gastroduodenoscopy on admission revealed an ulcer with an exposed vessel at the duodenal bulb. During endoscopic clipping for prevention of re-bleeding, a large amount of bleeding from the vessel was observed. Hemostasis was achieved after the procedure. However, 7 days later, the patient passed a large amount of tarry stools and experienced hypovolemic shock. Endoscopic re-examination revealed a pulsatile aneurysmal vessel at the base of the duodenal ulcer...
October 2015: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Mikihiro Fujiya, Aki Sakatani, Tatsuya Dokoshi, Kazuyuki Tanaka, Katsuyoshi Ando, Nobuhiro Ueno, Takuma Gotoh, Shin Kashima, Motoya Tominaga, Yuhei Inaba, Takahiro Ito, Kentaro Moriichi, Hiroki Tanabe, Katsuya Ikuta, Takaaki Ohtake, Kinnichi Yokota, Jiro Watari, Yusuke Saitoh, Yutaka Kohgo
The clinical importance of Crohn's disease (CD)-specific lesions in the upper gastrointestinal tract (upper GIT) has not been sufficiently established. The aim of this case-control study is to investigate the characteristic findings of CD in the upper GIT. In 2740 patients who underwent gastroduodenoscopy at Asahikawa Medical University between April 2011 and December 2012, 81 CD patients, 81 gender- and age-matched non-IBD patients, and 66 ulcerative colitis (UC) patients were investigated in the present study...
September 2015: Medicine (Baltimore)
Jinru Xue, Haixin Yu, Jidong Yan, Na Ren, Yi Yang, Xueju Wang, Yan Wang
A 55-year-old Chinese male was admitted to the hospital for epigastralgia and dysphagia with a two month history, and hematemesis and melena with a two-day history. Two lesions were found in the esophagus and stomach by esophago--gastroduodenoscopy and computed tomography. The patient underwent subtotal esophagectomy and gastrectomy, esophagogastric anastomosis above the aortic arch, and thoracic-abdominal two-field lymph node dissection. Pathological and immumohistochemical studies showed that both lesions had the same form of poorly differentiated carcinoma with dense lymphoid stroma, which was diagnosed as lymphoepithelioma-like carcinoma (LELC)...
2015: International Journal of Clinical and Experimental Medicine
Knut E A Lundin, Cisca Wijmenga
Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap between these diseases has been revealed and further insights into the pathophysiology of coeliac disease and autoimmunity have been gained. However, genetic screening is not sensitive and specific enough to accurately predict disease development. The current method to diagnose individuals with coeliac disease is serological testing for the presence of autoantibodies whilst the patient is on a regular, gluten-containing diet, followed by gastroduodenoscopy with duodenal biopsy...
September 2015: Nature Reviews. Gastroenterology & Hepatology
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