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https://www.readbyqxmd.com/read/28110494/a-systematic-review-of-cognitive-effects-of-exercise-in-depression
#1
N Brondino, M Rocchetti, L Fusar-Poli, E Codrons, L Correale, M Vandoni, C Barbui, P Politi
OBJECTIVE: The aim of the present systematic review and meta-analysis was to evaluate the impact of physical exercise on cognitive symptoms in depressed adult patients. METHODS: Systematic literature search was performed in Web of Science™ and CINAHL from inception to August 2016. Two reviewers independently selected randomized trials evaluating the effect of exercise on cognitive functions in patients with a validated diagnosis of depression. Outcome measures included global cognition and different cognitive domains (speed of processing, attention/vigilance, working memory, verbal and visual memory, and reasoning)...
January 22, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28110442/correlates-of-health-related-quality-of-life-in-young-old-and-old-old-community-dwelling-older-adults
#2
Élvio R Quintal Gouveia, Bruna R Gouveia, Andreas Ihle, Matthias Kliegel, José A Maia, Sergi Bermudez I Badia, Duarte L Freitas
PURPOSE: This study aimed (1) to examine the role of potential correlates of HRQoL in a large representative sample of older adults, and (2) to investigate whether the relationships between HRQoL and potential factors differ as a function of HRQoL component (physical vs. mental) and/or age cohort (young-old vs. old-old). METHODS: This cross-sectional study included 802 older adults aged 60-79 years old. HRQoL was assessed using the SF-36 questionnaire. Functional fitness was assessed using the Senior Fitness Test...
January 21, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28110433/a-comprehensive-analysis-of-cardiac-valve-plane-displacement-in-healthy-adults-age-stratified-normal-values-by-cardiac-magnetic-resonance
#3
Marco M Ochs, Thomas Fritz, Florian André, Johannes Riffel, Derliz Mereles, Matthias Müller-Hennessen, Evangelos Giannitsis, Hugo A Katus, Matthias G Friedrich, Sebastian J Buss
Cardiac valve plane displacement (CVPD) reflects longitudinal LV function. The purpose of the present study was to determine regional heterogeneity of CVPD in healthy adults to provide normal values by cardiac magnetic resonance (CMR). We measured the anterior aortic plane systolic excursion (AAPSE); the anterior, anterolateral, inferolateral, inferior, and inferoseptal mitral annular plane systolic excursion (MAPSE); and the lateral tricuspid annulus plane systolic excursion (TAPSE). Systolic excursion was measured as the distance from peak end-diastolic to peak end-sysstolic annular position (peak-to-peak) in cine images acquired in 2-, 3- and 4-chamber views...
January 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28110410/neurophysiological-assessment-of-brain-dysfunction-in-critically-ill-patients-an-update
#4
REVIEW
Eric Azabou, Catherine Fischer, Jean Michel Guerit, Djillali Annane, François Mauguiere, Fréderic Lofaso, Tarek Sharshar
The aim of this review was to provide up-to-date information about the usefulness of clinical neurophysiology testing in the management of critically ill patients. Evoked potentials (EPs) and electroencephalogram (EEG) are non-invasive clinical neurophysiology tools that allow an objective assessment of the central nervous system's function at the bedside in intensive care unit (ICU). These tests are quite useful in diagnosing cerebral complications, and establishing the vital and functional prognosis in ICU...
January 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28110366/atomoxetine-treatment-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-adhd-a-comprehensive-meta-analysis-of-outcomes-on-parent-rated-core-symptomatology
#5
REVIEW
Jessica L Gayleard, Matthew P Mychailyszyn
Attention-Deficit/Hyperactivity Disorder (ADHD) impacts a significant number of children and adolescents and often leads to deleterious functional impairment. Psychostimulant medication has historically been the first line of pharmacological intervention, though recent years have seen greater attention paid to non-stimulant alternatives. The objective of the present study was to conduct the most comprehensive meta-analysis to date evaluating the efficacy of atomoxetine in reducing core symptomatology of ADHD according to parent report...
January 21, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28110230/identification-of-the-autotrophic-denitrifying-community-in-nitrate-removal-reactors-by-dna-stable-isotope-probing
#6
Wei Xing, Jinlong Li, Yuan Cong, Wei Gao, Zhongjun Jia, Desheng Li
Autotrophic denitrification has attracted increasing attention for wastewater with insufficient organic carbon sources. Nevertheless, in situ identification of autotrophic denitrifying communities in reactors remains challenging. Here, a process combining micro-electrolysis and autotrophic denitrification with high nitrate removal efficiency was presented. Two batch reactors were fed organic-free nitrate influent, with H(13)CO3(-) and H(12)CO3(-) as inorganic carbon sources. DNA-based stable-isotope probing (DNA-SIP) was used to obtain molecular evidence for autotrophic denitrifying communities...
January 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28110184/structural-analysis-of-binding-functionality-of-folic-acid-peg-dendrimers-against-folate-receptor
#7
Diana Sampogna-Mireles, Ingrid D Araya-Durán, Valeria Márquez-Miranda, Jesús A Valencia-Gallegos, Fernando D González-Nilo
Dendrimers functionalized with folic acid (FA) are drug delivery systems that can selectively target cancer cells with folate receptors (FR-α) overexpression. Incorporation of polyethylene glycol (PEG) can enhance dendrimers solubility and pharmacokinetics, but ligand-receptor binding must not be affected. In this work we characterized, at atomic level, the binding functionality of conventional site-specific dendrimers conjugated with FA with PEG 750 or PEG 3350 as a linker. After Molecular Dynamics simulation, we observed that both PEG's did not interfere over ligand-receptor binding functionality...
January 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28110149/treatment-of-model-and-galvanic-waste-solutions-of-copper-ii-ions-using-a-lignin-inorganic-oxide-hybrid-as-an-effective-sorbent
#8
Filip Ciesielczyk, Przemysław Bartczak, Łukasz Klapiszewski, Teofil Jesionowski
A study was made concerning the removal of copper(II) ions from model and galvanic waste solutions using a new sorption material consisting of lignin in combination with an inorganic oxide system. Specific physicochemical properties of the material resulted from combining the activity of the functional groups present in the structure of lignin with the high surface area of the synthesized oxide system (585m(2)/g). Analysis of the porous structure parameters, particle size and morphology, elemental composition and characteristic functional groups confirmed the effective synthesis of the new type of sorbent...
January 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28110145/virusseeker-a-computational-pipeline-for-virus-discovery-and-virome-composition-analysis
#9
Guoyan Zhao, Guang Wu, Efrem S Lim, Lindsay Droit, Siddharth Krishnamurthy, Dan H Barouch, Herbert W Virgin, David Wang
The advent of Next Generation Sequencing (NGS) has vastly increased our ability to discover novel viruses and to systematically define the spectrum of viruses present in a given specimen. Such studies have led to the discovery of novel viral pathogens as well as broader associations of the virome with diverse diseases including inflammatory bowel disease, severe acute malnutrition and HIV/AIDS. Critical to the success of these efforts are robust bioinformatic pipelines for rapid classification of microbial sequences...
January 18, 2017: Virology
https://www.readbyqxmd.com/read/28110118/supporting-fingerprint-identification-assessments-using-a-skin-stretch-model-a-preliminary-study
#10
Rebecca Lee, Bruce Comber, Joshua Abraham, Michael Wagner, Chris Lennard, Xanthe Spindler, Claude Roux
To support fingerprint expert opinion, this research proposes an approach that combines subjective human analysis (as currently applied by fingerprint practitioners) with a statistical test of the result. This approach relies on the hypothesis that there are limits to the distortion caused by skin stretch. Such limits can be modelled by applying a multivariate normal probability density function to the distances and angle formed by a marked ridge characteristic and the two closest neighbouring minutiae. This study presents a model tested on 5 donors in total...
January 5, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28110100/transport-of-outer-membrane-lipids-in-mycobacteria
#11
REVIEW
Megan H Touchette, Jessica C Seeliger
The complex organization of the mycobacterial cell wall poses unique challenges for the study of its assembly. Although mycobacteria are classified evolutionarily as Gram-positive bacteria, their cell wall architecture more closely resembles that of Gram-negative organisms. They possess not only an inner cytoplasmic membrane, but also a bilayer outer membrane that encloses an aqueous periplasm and includes diverse lipids that are required for the survival and virulence of pathogenic species. Questions surrounding how mycobacterial outer membrane lipids are transported from where they are made in the cytoplasm to where they function at the cell exterior are thus similar, and similarly compelling, to those that have driven the study of Gram-negative outer membrane transport pathways...
January 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28110070/mesoscale-porosity-at-the-dentin-enamel-junction-could-affect-the-biomechanical-properties-of-teeth
#12
Elsa Vennat, Wenlong Wang, Rachel Genthial, Bertrand David, Elisabeth Dursun, Aurélien Gourrier
: In this paper, the 3D-morphology of the porosity in dentin is investigated within the first 350 μm from the dentin-enamel junction (DEJ) by fluorescence confocal laser scanning microscopy (CLSM). We found that the porous microstructure exhibits a much more complex geometry than classically described, which may impact our fundamental understanding of the mechanical behavior of teeth and could have practical consequences for dental surgery. Our 3D observations reveal numerous fine branches stemming from the tubules which may play a role in cellular communication or mechanosensing during the early stages of dentinogenesis...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28110034/transcriptome-profiles-of-the-clam-meretrix-petechialis-hepatopancreas-in-response-to-vibrio-infection
#13
Fengjuan Jiang, Xin Yue, Hongxia Wang, Baozhong Liu
Microbial diseases have received much attention due to their enormous destruction of aquaculture, and Vibrio parahaemolyticus is one of the main pathogens that cause bacterial disease in the clam Meretrix petechialis. To better understand the molecular mechanisms of the immune response to Vibrio in M. petechialis, RNA-Seq was applied to explore global expression changes of hepatopancreas from this clam after Vibrio challenge. There were 199,318,966 clean reads obtained by Illumina sequencing, which were further assembled into 214,577 transcripts, and then 147,255 unigenes with an N50 of 1393 bp were identified...
January 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28110033/purification-characterization-and-functional-analysis-of-the-immune-molecule-lectin-from-the-haemolymph-of-blue-swimmer-crab-portunus-pelagicus-and-their-antibiofilm-properties
#14
Sangily Jayanthi, Ramachandran Ishwarya, Mahalingam Anjugam, Arokiadhas Iswarya, Sivashanmugam Karthikeyan, Baskaralingam Vaseeharan
The present study reveals purification and characterization of immune molecule lectin from the haemolymph of blue swimmer crab Portunus pelagicus (Pp-Lec). The Pp-Lec was purified by affinity chromatography with mannose coupled sepharose CL-4B column and it exhibits single band with a molecular weight of 155 kDa in SDS-PAGE. The surface morphology of purified Pp-Lec displays the homogeneous nature of protein. A distinct peak with a retention time of 3.3 min was appeared in high performance liquid chromatography (HPLC) and X-ray diffraction (XRD) analysis expresses a single peak at 31...
January 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28109940/proteome-response-of-fish-under-multiple-stress-exposure-effects-of-pesticide-mixtures-and-temperature-increase
#15
Allison Gandar, Pascal Laffaille, Nathalie Marty-Gasset, Didier Viala, Caroline Molette, Séverine Jean
Aquatic systems can be subjected to multiple stressors, including pollutant cocktails and elevated temperature. Evaluating the combined effects of these stressors on organisms is a great challenge in environmental sciences. To the best of our knowledge, this is the first study to assess the molecular stress response of an aquatic fish species subjected to individual and combined pesticide mixtures and increased temperatures. For that, goldfish (Carassius auratus) were acclimated to two different temperatures (22 and 32°C) for 15 days...
January 15, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28109936/precision-phenotyping-in-heart-failure-and-pattern-clustering-of-ultrasound-data-for-the-assessment-of-diastolic-dysfunction
#16
Alaa Mabrouk Salem Omar, Sukrit Narula, Mohamed Ahmed Abdel Rahman, Gianni Pedrizzetti, Hala Raslan, Osama Rifaie, Jagat Narula, Partho P Sengupta
OBJECTIVES: The aim of this study was to investigate whether cluster analysis of left atrial and left ventricular (LV) mechanical deformation parameters provide sufficient information for Doppler-independent assessment of LV diastolic function. BACKGROUND: Medical imaging produces substantial phenotyping data, and superior computational analyses could allow automated classification of repetitive patterns into patient groups with similar behavior. METHODS: The authors performed a cluster analysis and developed a model of LV diastolic function from an initial exploratory cohort of 130 patients that was subsequently tested in a prospective cohort of 44 patients undergoing cardiac catheterization...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109901/study-of-ciprofloxacin-adsorption-and-regeneration-of-activated-carbon-prepared-from-enteromorpha-prolifera-impregnated-with-h3po4-and-sodium-benzenesulfonate
#17
Man Wang, Gang Li, Lihui Huang, Jing Xue, Quan Liu, Nan Bao, Ji Huang
Activated carbons were derived from Enteromorpha prolifera immersed in H3PO4 solution or the H3PO4 solution mixed with sodium benzenesulfonate (SBS), producing AC and AC-SBS. NaOH solution was employed in regeneration of ciprofloxacin (CIP)-loaded AC and AC-SBS to obtain RAC and RAC-SBS. The properties of the original and regenerated activated carbons were characterized by thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), N2 adsorption/desorption isotherms and Fourier transform infrared spectroscopy (FTIR)...
January 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28109881/production-of-aba-responses-requires-both-the-nuclear-and-cytoplasmic-functional-involvement-of-pyr1
#18
EunJoo Park, Tae-Houn Kim
Abscisic acid (ABA) enhances stress tolerant responses in plants against unfavorable environmental conditions. In Arabidopsis, ABA promotes interactions between PYR/PYL/RCARs and PP2C, thereby allowing SnRK2s to phosphorylate downstream components required for the regulation of gene expression or for gating ion channels. Because PYR1 is known to localize to nucleus and cytoplasm it is a question whether nuclear or cytoplasmic PYR1 confer different functions to the ABA signaling pathway, as has been previously shown for regulatory proteins...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109861/preoperative-rtms-language-mapping-in-speech-eloquent-brain-lesions-resected-under-general-anesthesia-a-pair-matched-cohort-study
#19
Philipp Hendrix, Sebastian Senger, Andreas Simgen, Christoph J Griessenauer, Joachim Oertel
OBJECTIVE: The value of preoperative rTMS language mapping for function preservation in surgery of speech eloquent lesions under general anesthesia remains to be determined. METHODS: The authors prospectively enrolled 20 consecutive right-handed patients with a malignant, left-sided perisylvian language eloquent brain tumor. All patients were subjected to surgical resection under general anesthesia guided by preoperative rTMS language mapping (rTMS group, 2014 - 2016)...
January 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28109855/heterologous-expression-and-characterization-of-plant-taxadiene-5%C3%AE-hydroxylase-cyp725a4-in-escherichia-coli
#20
John Edward Rouck, Bradley Walters Biggs, Amogh Kambalyal, William R Arnold, Marjan De Mey, Parayil Kumaran Ajikumar, Aditi Das
Taxadiene-5α-Hydroxylase (CYP725A4) is a membrane-bound plant cytochrome P450 that catalyzes the oxidation of taxadiene to taxadiene-5α-ol. This oxidation is a key step in the production of the valuable cancer therapeutic and natural plant product, taxol. In this work, we report the bacterial expression and purification of six different constructs of CYP725A4. All six of these constructs are N-terminally modified and three of them are fused to cytochrome P450 reductase to form a chimera construct. The construct with the highest yield of CYP725A4 protein was then selected for substrate binding and kinetic analysis...
January 18, 2017: Protein Expression and Purification
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