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https://www.readbyqxmd.com/read/29220783/a-study-to-compare-the-differences-between-genders-in-psychiatric-comorbidities-in-individuals-with-psychoses
#1
Praveen Das, Priya Sreedaran, Ashok Mv
BACKGROUND: Psychiatric comorbidities worsen the outcome and increase severity of suffering in psychotic disorders. Gender differences have also been found to impact the severity and outcome in psychoses. In this background, this study attempted to compare psychiatric comorbidity between genders. AIMS AND OBJECTIVES: The aim was to compare psychiatric co-morbidity between men and women with psychotic disorders. METHODOLOGY: A descriptive cross sectional study design was used...
November 29, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29220746/testing-bidirectional-relationships-between-alcohol-use-and-depressive-symptoms-what-is-the-role-of-the-serotonin-transporter-gene
#2
Roy Otten, Carmen S van der Zwaluw, Rutger C Engels
Alcohol abuse often co-exists with a major depressive disorder. In order to understand the development of this comorbidity, it is important to concentrate on the preceding process. It has been suggested that the link between alcohol use and depressive symptoms is a result of an interaction with genetic factors. The aim of this study was to longitudinally examine the effect of the 5-HTTLPR genotype on the association between depressive symptoms and alcohol use in a Dutch community sample. Following a stepwise approach, bivariate correlations, longitudinal regression analyses, and latent growth curve analyses were separately conducted for 316 males and 321 females...
August 13, 2017: Alcohol
https://www.readbyqxmd.com/read/29220684/predictors-of-remission-from-ptsd-symptoms-after-sexual-and-non-sexual-trauma-in-the-community-a-mediated-survival-analytic-approach
#3
Mario Müller, Vladeta Ajdacic-Gross, Stephanie Rodgers, Birgit Kleim, Erich Seifritz, Stefan Vetter, Stephan T Egger, Wulf Rössler, Enrique Castelao, Martin Preisig, Caroline Vandeleur
Epidemiological data on the chronicity of posttraumatic stress disorder (PTSD) symptoms in relation to trauma type and underlying pathways are rare. The current study explored how PTSD symptoms change over time across different trauma types and examined mediators of their persistence. A trauma-exposed community sample, whereof approximately one quarter met diagnostic criteria for PTSD, provided retrospective data on the duration of PTSD symptoms. Those who remitted and those who had not at the time of assessment were compared regarding worst trauma, symptom severity, comorbidity, demographic and treatment-seeking variables...
December 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29220680/adherence-to-physical-activity-recommendations-and-physical-and-mental-health-risk-in-people-with-severe-mental-illness-in-uganda
#4
Davy Vancampfort, Michel Probst, David Basangwa, Marc De Hert, Inez Myin-Germeys, Ruud van Winkel, Philip B Ward, Simon Rosenbaum, James Mugisha
This study investigated cardio-metabolic risk factors among patients with severe mental illness who do or do not meet the recommendations of 150min per week of physical activity. A secondary aim was to assess whether those that do meet the recommendations report lower levels of mental health symptoms. 107 (60♀) Ugandan in- and outpatients (mean age=34.4 ± 9.7 years) with severe mental illness (depression=7, bipolar disorder=55, schizophrenia=45) completed the Physical Activity Vital Sign (PAVS) method and Brief Symptoms Inventory -18...
November 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29220570/neuromicrobiology-how-microbes-influence-the-brain
#5
Cesar de la Fuente-Nunez, Beatriz Torres Meneguetti, Octávio Luiz Franco, Timothy K Lu
We review here recent discoveries in the exciting new field of neuromicrobiology. This field encompasses the interactions between the microbiome and the central nervous system. The microbiome has a tremendous impact on human health. In particular, the gut microbiota may play a key role in many essential processes in health and disease via the activity of the gut-brain axis, possibly contributing to autism spectrum disorders, Alzheimer's disease, Parkinson's disease, depression, and anxiety disorder. Gut microbes may also be involved in nociception, complex host behaviors, and brain development...
December 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#6
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29218451/the-trajectory-from-mood-to-obesity
#7
REVIEW
Judith Wurtman, Richard Wurtman
PURPOSE OF REVIEW: To describe and explain the relationships between mood disturbances and the development of obesity. RECENT FINDINGS: That depression, anxiety, PTSD, or severe stresses can promote obesity as a side-effect of the drugs used to treat them, or through "carbohydrate craving" to enhance brain serotonin synthesis and alleviate dysphoria by consuming foods that are rich in both carbohydrates and fats. That seasonal affective disorder and severe PMS can independently cause patients to overconsume foods rich in both carbohydrates and fats...
December 7, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/29217995/the-alteration-of-irisin-brain-derived-neurotrophic-factor-axis-parallels-severity-of-distress-disorder-in-bronchial-asthma-patients
#8
Magdolna E Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria E Varga, Ildiko Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, Csaba Papp, Rudolf Gesztelyi, Judit Zsuga
Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29217840/the-role-of-anxious-distress-in-immune-dysregulation-in-patients-with-major-depressive-disorder
#9
Roxanne Gaspersz, Femke Lamers, Gayle Wittenberg, Aartjan T F Beekman, Albert M van Hemert, Robert A Schoevers, Brenda W J H Penninx
Although depression with anxious distress appears to be a clinically relevant subtype of major depressive disorder (MDD), whether it involves specific pathophysiology remains unclear. Inflammation has been implicated, but not comprehensively studied. We examined within a large MDD sample whether anxious distress and related anxiety features are associated with differential basal inflammation and innate cytokine production capacity. Data are from 1078 MDD patients from the Netherlands Study of Depression and Anxiety...
December 8, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29217834/gender-specific-alteration-of-energy-balance-and-circadian-locomotor-activity-in-the-crtc1-knockout-mouse-model-of-depression
#10
Clara Rossetti, Daniel Sciarra, Jean-Marie Petit, Chin B Eap, Olivier Halfon, Pierre J Magistretti, Benjamin Boutrel, Jean-René Cardinaux
Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy balance regulation. Crtc1 -/- mice rapidly develop a depressive-like and obese phenotype in early adulthood, and are therefore a relevant animal model to explore possible common mechanisms underlying mood disorders and obesity. Here, the obese phenotype of male and female Crtc1 -/- mice was further characterized by investigating CRTC1's role in the homeostatic and hedonic regulation of food intake, as well as its influence on daily locomotor activity...
December 8, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29217725/atrial-fibrillation-in-patients-with-severe-mental-disorders-and-the-risk-of-stroke-fatal-thromboembolic-events-and-bleeding-a-nationwide-cohort-study
#11
Mette Søgaard, Flemming Skjøth, Jette Nordstrøm Kjældgaard, Torben Bjerregaard Larsen, Søren Pihlkjær Hjortshøj, Sam Riahi
OBJECTIVES: Outcomes of atrial fibrillation (AF) in patients with severe mental disorders are largely unknown. We compared rates of stroke, fatal thromboembolic events and bleeding in patients with AF with and without mental disorders. DESIGN: Nationwide registry-based cohort study. SETTING: Denmark (population 5.6 million), 2000-2015. PARTICIPANTS: Patients with AF with schizophrenia (n=534), severe depression (n=400) or bipolar disease (n=569) matched 1:5 on age, sex and calendar time to patients with AF without mental disorders...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29217452/specific-agreement-on-ordinal-and-multiple-nominal-outcomes-can-be-calculated-for-more-than-two-raters
#12
Henrica C W de Vet, Margriet G Mullender, Iris Eekhout
OBJECTIVE: The concept of specific agreement has been proposed for dichotomous outcomes for two and more raters. We aim to extend this concept for variables with more than two ordinal or nominal categories and more than two raters. STUDY DESIGN AND SETTING: We used two data sets: 4 plastic surgeons classifying photographs after breast reconstruction on a 5 point ordinal scale; and 6 raters classifying psychiatric patients into 5 diagnostic categories. For m raters, all (i...
December 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29217258/predictive-brain-networks-for-major-depression-in-a-semi-multimodal-fusion-hierarchical-feature-reduction-framework
#13
Jie Yang, Yingying Yin, Zuping Zhang, Jun Long, Jian Dong, Yuqun Zhang, Zhi Xu, Lei Li, Jie Liu, Yonggui Yuan
Major depressive disorder (MDD) is characterized by dysregulation of distributed structural and functional networks. It is now recognized that structural and functional networks are related at multiple temporal scales. The recent emergence of multimodal fusion methods has made it possible to comprehensively and systematically investigate brain networks and thereby provide essential information for influencing disease diagnosis and prognosis. However, such investigations are hampered by the inconsistent dimensionality features between structural and functional networks...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29217173/7-fluoro-1-3-diphenylisoquinoline-reverses-motor-and-non-motor-symptoms-induced-by-mptp-in-mice-role-of-striatal-neuroinflammation
#14
Tuane Bazanella Sampaio, Marcel Henrique Marcondes Sari, Ana Paula Pesarico, Anderson Carboni Mantovani, Gilson Zeni, Cristina Wayne Nogueira
Parkinson's disease (PD) is a dopaminergic neurodegenerative disorder, which presents motor and non-motor symptoms.7-Fluoro-1,3-diphenylisoquinoline (FDPI) is an isoquinoline compound with antioxidant and antidepressant properties. This study investigated whether FDPI reverses motor and non-motor symptoms in an acute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It was also assessed the anti-inflammatory mechanisms in FDPI pharmacological action. C57Bl/6 male adult mice received four MPTP (20mg/kg, intraperitoneal) or saline (vehicle) injections to induce an acute PD model...
December 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29216892/opiate-agonist-treatment-to-improve-health-of-individuals-with-opioid-use-disorder-in-lebanon
#15
Ali Ghaddar, Zeinab Abbas, Ramzi Haddad
BACKGROUND: Opioid agonist therapy has been widely used to reduce harms among individuals with opioid use disorder but its effectiveness has not been evaluated in the Middle East North African (MENA) region. This study aims to evaluate the effectiveness of a program using opioid agonist therapy in combination with psychosocial support on improving psychological and social well-being, reducing arrest, and reducing risky behavior in individuals with opioid use disorder in Lebanon. METHODS: A one-group pre-test post-test design study was performed at SKOUN Lebanese Addiction Centre between January 2013 and December 2014...
December 8, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/29216871/mental-health-literacy-among-pediatric-hospital-staff-in-the-united-arab-emirates
#16
Nabeel Al-Yateem, Rachel Rossiter, Walter Robb, Alaa Ahmad, Mahmoud Saleh Elhalik, Sumaya Albloshi, Shameran Slewa-Younan
BACKGROUND: In the United Arab Emirates (UAE) 35% of the population are aged 0-24 years. A significant proportion of these young people are living with chronic conditions (e.g., asthma, type 1 diabetes, cardiac conditions, and genetically-transmitted conditions such as thalassemia and cystic fibrosis). This group has increased vulnerability to developmental delays and mental health problems, and is increasingly coming to the attention of service providers in mainstream schools, primary healthcare centers, and pediatric hospitals...
December 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29216784/evaluation-of-peripheral-serotonin-content-and-%C3%AE-2-adrenergic-receptor-function-as-potential-markers-for-life-long-recurrent-depressive-disorder-by-using-methodological-improvements
#17
Boris Aleksovski, Antoni Novotni, Viktorija Vujović, Vladimir Rendevski, Nensi Manusheva, Violeta Neceva, Ana Filipce, Aleksandar Risteski, Vasko Aleksovski, Icko Gjorgoski
OBJECTIVE: We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD). METHODS: 26 drug-free patients with life-long RDD and 31 healthy controls were included in the study. Several methodological improvements in blood collection and platelet isolation were implemented following the present standards in Haematology and Light transmission aggregometry...
December 7, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29216557/subcortical-volumetric-differences-between-clinical-stages-of-young-people-with-affective-and-psychotic-disorders
#18
Peta S Eggins, Sean N Hatton, Daniel F Hermens, Ian B Hickie, Jim Lagopoulos
The aim of this study was to investigate differences in subcortical and hippocampal volumes between healthy controls, young people at an early stage of affective and psychotic disorders and those in more advanced stages, to identify markers associated with functional outcomes and illness severity. Young people presenting to youth mental health services with admixtures of depressive, manic and psychotic symptoms (n = 141), and healthy counterparts (n = 49), aged 18-25 were recruited. Participants underwent magnetic resonance imaging, clinical assessments and were rated as to their current clinical stage...
November 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29216484/beliefs-about-the-causes-of-and-treatments-for-depression-and-bipolar-disorder-among-south-koreans
#19
Subin Park, Hyesue Jang, Adrian Furnham, Mina Jeon, Se Jin Park
Public beliefs about psychiatric disorders are important for understanding help-seeking behaviours. We investigated factors that affect South Koreans' beliefs about the causes and treatment of depression and bipolar disorder. We recruited 654 participants aged 15-54 years using an online panel survey. Participants completed two questionnaires: 34 possible causes of and 33 possible treatments for depression and bipolar disorder. For both disorders, the questionnaires about causes revealed four factors: social-environmental, God/fate, heath/lifestyle, and biological; the questionnaires about treatments revealed five factors: self-help/stress management, physical treatment/health management, seeking mental health services, religious help, and resting...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29216442/lycopene-depresses-glutamate-release-through-inhibition-of-voltage-dependent-ca-sup-2-sup-entry-and-protein-kinase-c-in-rat-cerebrocortical-nerve-terminals
#20
Cheng-Wei Lu, Chi-Feng Hung, Wei-Horng Jean, Tzu-Yu Lin, Shu-Kuei Huang, Su Jane Wang
Lycopene is a natural dietary carotenoid which was reported to exhibit neuroprotective profile. Considering that excitotoxicity and cell death induced by glutamate are involved in many brain disorders, the effect of lycopene on glutamate release in rat cerebrocortical nerve terminals and the possible mechanism involved in such effect was investigated. We observed here that lycopene inhibited 4-aminopyridine (4-AP)-evoked glutamate release and intrasynaptosomal Ca <sup>2+<sup> concentration elevation...
December 7, 2017: Canadian Journal of Physiology and Pharmacology
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