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https://www.readbyqxmd.com/read/28820902/from-hospitalization-records-to-surveillance-the-use-of-local-patient-profiles-to-characterize-cholera-in-vellore-india
#1
Melissa S Cruz, Tania M AlarconFalconi, Meghan A Hartwick, Aishwarya Venkat, Hanna Y Ehrlich, Shalini Anandan, Honorine D Ward, Balaji Veeraraghavan, Elena N Naumova
Despite availability of high quality medical records, health care systems often do not have the resources or tools to utilize these data efficiently. Yet, hospital-based, laboratory-confirmed records may pave the way for building reliable surveillance systems capable of monitoring temporal trends of emerging infections. In this communication, we present a new tool to compress and visualize medical records with a local population profile (LPP) approach, which transforms information into statistically comparable patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28820899/two-disjunct-pleistocene-populations-and-anisotropic-postglacial-expansion-shaped-the-current-genetic-structure-of-the-relict-plant-amborella-trichopoda
#2
Rémi Tournebize, Stéphanie Manel, Yves Vigouroux, François Munoz, Alexandre de Kochko, Valérie Poncet
Past climate fluctuations shaped the population dynamics of organisms in space and time, and have impacted their present intra-specific genetic structure. Demo-genetic modelling allows inferring the way past demographic and migration dynamics have determined this structure. Amborella trichopoda is an emblematic relict plant endemic to New Caledonia, widely distributed in the understory of non-ultramafic rainforests. We assessed the influence of the last glacial climates on the demographic history and the paleo-distribution of 12 Amborella populations covering the whole current distribution...
2017: PloS One
https://www.readbyqxmd.com/read/28820772/the-individual-experience-of-aging-patients-and-the-current-service-provision-in-the-context-of-italian-forensic-psychiatry-a-case-study
#3
Claudio Di Lorito, Luca Castelletti, Giuseppa Tripi, Maria Gloria Gandellini, Tom Dening, Birgit Völlm
INTRODUCTION: After the recent development of residential units for the execution of security measures managed by the National Health Service and the closing down of forensic psychiatric hospitals, no study has been conducted to investigate the individual experience of aging patients and to assess whether the new service is adequately meeting their needs. We aimed to explore the experience of the service of a sample of patients aged 50 years and above living in one of the Italian residential units for the execution of security measures...
July 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28820750/the-new-realization-about-cribriform-prostate-cancer
#4
Kenneth A Iczkowski, Gladell P Paner, Theodorus Van der Kwast
Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reached these conclusions concordantly. Not only does this justify removal of all cribriform cancer from Gleason grade 3, it shows that cribriform cancer has pathologic, outcome, and molecular features distinct from noncribriform Gleason grade 4...
August 17, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28820706/high-prevalence-of-treponema-pallidum-infection-in-brazilian-prisoners
#5
Maisa Estopa Correa, Julio Croda, Ana Rita Coimbra Motta de Castro, Sandra Maria do Valle Leone de Oliveira, Maurício Antonio Pompilio, Ronaldo Omizolo de Souza, Júlio Henrique Ferreira de Sá Queiroz, Kesia Esther da Silva, Albert L Ko, Simone Simionatto
The number of new syphilis cases in Brazil has risen alarmingly in recent years. However, there is limited data regarding syphilis prevalence in the Brazilian prison population. To facilitate the development of effective interventions, a cross-sectional study was undertaken to determine the prevalence of Treponema pallidum infection, active syphilis, and associated risk factors among Brazilian prisoners. We administered a questionnaire to a population-based sample of prisoners from 12 prisons in Central-West Brazil and collected sera for syphilis testing, from January to December 2013...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820683/malaria-in-the-guangxi-zhuang-autonomous-region-in-china-a-twelve-year-surveillance-data-study
#6
Kangming Lin, Haiyan Wei, Weikang Jiang, Jun Li, Weiwei Zhang, Shujiao Wei, Yichao Yang, Yaming Huang, Xiangyang Feng, Hong Tu, Jun Feng
The incidence of an indigenous malaria, defined as malaria acquired by a local mosquito transmission, declined from 2004 to 2015 in the Guangxi Zhuang Autonomous Region. However, imported malaria, defined as malaria acquired from other endemic regions outside of China, has been increasing in the region, as in the rest of the country, particularly the disease caused by Plasmodium falciparum. A retrospective study was conducted to explore malaria-endemic characteristics in Guangxi during the 2004-2015 timeframe; a total of 2,726 confirmed malaria cases were reported, and the majority (90...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820557/papillary-muscle-rupture-in-an-adolescent-with-no-coronary-lesions
#7
Tatjana Lejko Zupanc, Mateja Logar
A 21-year-old man with Wolff-Parkinson-White syndrome presented to the authors' hospital with ventricular fibrillation. Coronary angiography failed to demonstrate coronary stenosis, but temporary mechanical circulatory support resolved the ventricular fibrillation and the patient was extubated eight days later. On the next day, however, he had to be re-intubated with symptoms of congestive heart failure. Echocardiography revealed new severe mitral regurgitation and a mobile mass, while emergency surgery revealed a posteromedial papillary muscle rupture (PMR)...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28820551/fungal-endocarditis-due-to-aspergillus-oryzae-the-first-case-reported-in-the-literature
#8
Andrea Mazza, Nicola Luciani, Marco Luciani, Federico Cammertoni, Alessia Giaquinto, Natalia Pavone, Piergiorgio Bruno, Massimo Massetti
Infective endocarditis (IE) is a severe disease with high mortality and morbidity. Prosthetic valve endocarditis is a life-threatening complication which can occur in less than 10% of patients with valve prosthesis. A fungal etiology of IE is rare and accounts for only 2-4% of all case of endocarditis, but is associated with a higher mortality and morbidity. Herein is reported the first case of fungal endocarditis of aortic valve prosthesis due to Aspergillus oryzae in a 67-year-old caucasian man who nine years previously underwent mitral and aortic valve replacement with mechanical prostheses, and tricuspid annuloplasty for acute IE due to Enterococcus spp...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28820533/actinomycetes-still-a-source-of-novel-antibiotics
#9
REVIEW
Olga Genilloud
Covering: 2006 to 2017Actinomycetes have been, for decades, one of the most important sources for the discovery of new antibiotics with an important number of drugs and analogs successfully introduced in the market and still used today in clinical practice. The intensive antibacterial discovery effort that generated the large number of highly potent broad-spectrum antibiotics, has seen a dramatic decline in the large pharma industry in the last two decades resulting in a lack of new classes of antibiotics with novel mechanisms of action reaching the clinic...
August 18, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28820405/antiphospholipid-syndrome-and-monocytes-new-aspects
#10
A Blbulyan, A Martirosyan, M Petrek, Z Navratilova, G Manukyan
After discovery of antiphospholipid syndrome (APS) our understanding of molecular mechanisms of living matter has become more sophisticated and on this way monocytes has become crucial player, particularly in pathogenesis of APS. Thrombotic and non-thrombotic complications of APS could be explained by monocytes' activation too. But mechanisms underlying their activation are poorly investigated. So we aimed to determine transcriptional activity of monocytes after exposing them to low concentrations of lipopolysaccharide (LPS) and LPS+ATP using comparative of RT-PCR...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28820346/attitudes-and-potential-barriers-towards-hepatitis-c-treatment-in-patients-with-and-without-hiv-coinfection
#11
P R Allyn, S M O'Malley, J Ferguson, C H Tseng, K W Chew, D Bhattacharya
This study aimed to assess attitudes and potential barriers towards treatment in patients with hepatitis C virus (HCV) infection, comparing those with and without HIV coinfection. A cross-sectional survey of 82 HCV-infected adults with and without HIV was conducted in greater Los Angeles between November 2013 and July 2015. Overall, there were 53 (64.6%) with HIV coinfection, 20 (25.0%) with self-reported cirrhosis, and 22 (26.8%) with a history of prior HCV treatment. Of all, 93.2% wanted HCV treatment, but 45...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28820339/emergence-of-visceral-leishmaniasis-in-sri-lanka-a-newly-established-health-threat
#12
H V Y D Siriwardana, P Karunanayake, L Goonerathne, N D Karunaweera
BACKGROUND: Sri Lanka is a new focus of human cutaneous leishmaniasis caused by a genetic variant of usually visceralizing parasite Leishmania donovani. Over 3000 cases have been reported to our institution alone, during the past two decades. Recent emergence of visceral leishmaniasis is of concern. METHODS: Patients suspected of having visceral leishmaniasis (n = 120) fulfilling at least two of six criteria (fever > 2 weeks, weight loss, tiredness affecting daily functions, splenomegaly, hepatomegaly and anemia) were studied using clinic-epidemiological, immunological and haematological parameters...
August 18, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28820298/surveillance-for-hemorrhagic-septicemia-in-buffalo-bubalus-bubalis-as-an-aid-to-range-expansion-of-the-javan-rhinoceros-rhinoceros-sondaicus-in-ujung-kulon-national-park-indonesia
#13
Kurnia Oktavia Khairani, Daryl Nydam, M Julia Felippe, Pat McDonough, Jason Barry, Rois Mahmud, M Haryono, Robin W Radcliffe
The Javan rhinoceros (Rhinoceros sondaicus) of Ujung Kulon National Park (UKNP) is the crown jewel of Indonesia's rich natural history. The park lies on a peninsula surrounded by coastline and agriculture-dominated landscapes. The invasion of water buffalo (Bubalus bubalis) into the park carries a substantial health risk to the Javan rhinoceros and threatens plans to establish a new population outside of its only current range in UKNP. Hemorrhagic septicemia (HS), known locally as septicemia epizootica and caused by Pasteurella multocida B:2, could thwart Indonesia's efforts to expand the range of the Javan rhinoceros...
August 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28820271/cam-deformities-and-limited-hip-range-of-motion-are-associated-with-early-osteoarthritic-changes-in-adolescent-athletes-a-prospective-matched-cohort-study
#14
Cody C Wyles, Germán A Norambuena, Benjamin M Howe, Dirk R Larson, Bruce A Levy, Brandon J Yuan, Robert T Trousdale, Rafael J Sierra
BACKGROUND: The natural history of femoroacetabular impingement (FAI) remains incompletely understood. In particular, there is limited documentation of joint damage in adolescent patients with limited range of motion (LROM) of the hip, which is commonly associated with FAI. PURPOSE: To evaluate changes in magnetic resonance imaging (MRI), radiographs, and clinical examinations over 5 years in a group of athletes from a wide variety of sports with asymptomatic LROM of the hip compared with matched controls...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28820183/technique-of-retinal-gene-therapy-delivery-of-viral-vector-into-the-subretinal-space
#15
K Xue, M Groppe, A P Salvetti, R E MacLaren
PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene therapy technique involved pre-operative planning with optical coherence tomography (OCT) and autofluorescence (AF) imaging, 23 G pars plana vitrectomy, internal limiting membrane staining with Membrane Blue Dual (DORC BV, Zuidland, Netherlands), a two-step subretinal injection using a 41 G Teflon tipped cannula (DORC) first with normal saline to create a parafoveal bleb followed by slow infusion of viral vector via the same self-sealing retinotomy...
August 18, 2017: Eye
https://www.readbyqxmd.com/read/28820158/systematic-analysis-of-ocular-trauma-by-a-new-proposed-ocular-trauma-classification
#16
Bhartendu Shukla, Rupesh Agrawal, Dhananjay Shukla, Sophia Seen
PURPOSE: The current classification of ocular trauma does not incorporate adnexal trauma, injuries that are attributable to a nonmechanical cause and destructive globe injuries. This study proposes a new classification system of ocular trauma which is broader-based to allow for the classification of a wider range of ocular injuries not covered by the current classification. METHODS: A clinic-based cross-sectional study to validate the proposed classification. We analyzed 535 cases of ocular injury from January 1, 2012 to February 28, 2012 over a 4-year period in an eye hospital in central India using our proposed classification system and compared it with conventional classification...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820068/known-triterpenes-and-their-derivatives-as-scaffolds-for-the-development-of-new-therapeutic-agents-for-cancer
#17
Gregorio Peron, Giovanni Marzaro, Stefano Dall'Acqua
Plants produce several bioactive secondary metabolites whose are used as therapeutic agents to treat various diseases, among them cancer. Triterpenes are a category of secondary metabolites that exert inhibitory activity against multiple intracellular and extracellular targets in euchariotic cells. These targets are proteins involved in apoptosis, cell development and differentiation, angiogenesis, metastasis and inflammatory processes. The inhibition of their functions leads to decreased cellular growth, differentiation and migration, resulting in antitumor activity, as shown by the numerous published experimental results...
August 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28819988/behavior-change-following-hiv-diagnosis-findings-from-a-cohort-of-los-angeles-msm
#18
Pamina M Gorbach, Marjan Javanbakht, Robert K Bolan
The effect of an HIV diagnosis on subsequent behavior of men who have sex with men (MSM) remains unclear. From 2009 to 2012 the NIDA funded Metromates Study enrolled and followed for one year MSM seeking testing for HIV in Los Angeles, assessing those with new HIV diagnoses for acute/recent HIV infection. Behavioral data were collected via Computer-Assisted Self-Interview from 321 men of whom 125 were classified as recently HIV infected, 91 as not recently HIV infected, and 105 as HIV-negative. Differences over time between those with recent HIV infection, not recent HIV infection, and no HIV were evaluated using bivariate and multivariable analyses for repeat measures to assess associations between HIV group, behaviors and condomless receptive (CRAI), intersertive (CIAI), or any condomless anal intercourse (CAI)...
August 18, 2017: AIDS Care
https://www.readbyqxmd.com/read/28819951/metformin-a-new-old-drug
#19
Marta Patrycja Wróbel, Bogdan Marek, Dariusz Kajdaniuk, Dominika Rokicka, Aleksandra Szymborska-Kajanek, Krzysztof Strojek
For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. It is then combined with a sulfony-lurea, an incretin, flozin, or insulin, irrespective of the number of insulin injections per day. Besides its properties used in the treatment of diabetes, metformin has been treated for some time as a drug of a so-called pleiotropic activity, as each year brings new reports about its favourable effect in different conditions...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819950/successful-eus-guided-ethanol-ablation-of-insulinoma-four-year-follow-up-case-report-and-literature-review
#20
Krzysztof Dąbkowski, Paula Gajewska, Kamila Walter, Magdalena Londzin-Olesik, Andrzej Białek, Elżbieta Andrysiak-Mammos, Beata Kos-Kudła, Teresa Starzyńska
INTRODUCTION: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholic ablation, along with a literature review including 28 other previously described cases. The effectiveness, safety of the therapy, and technical procedure-related issues are summarised...
2017: Endokrynologia Polska
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