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https://www.readbyqxmd.com/read/28437461/comparison-of-risk-factors-and-outcomes-of-gestational-hypertension-and-pre-eclampsia
#1
Minxue Shen, Graeme N Smith, Marc Rodger, Ruth Rennicks White, Mark C Walker, Shi Wu Wen
BACKGROUND: It remains an enigma whether gestational hypertension (GH) and pre-eclampsia (PE) are distinct entities or different spectrum of the same disease. We aimed to compare the risk factors and outcomes between GH and PE. METHOD: A total of 7,633 pregnant women recruited between 12 and 20 weeks of gestation in the Ottawa and Kingston Birth Cohort from 2002 to 2009 were included in the analysis. Cox proportional hazards model was used to identify and compare the risk factors for GH and PE by treating gestational age at delivery as the survival time...
2017: PloS One
https://www.readbyqxmd.com/read/28434207/maternal-rates-of-lipolysis-and-glucose-production-in-late-pregnancy-are-independently-related-to-fetal-weight
#2
Barbro Diderholm, Kathryn Beardsall, Peter Murgatroyd, Christoph Lees, Jan Gustafsson, David Dunger
OBJECTIVE: Associations between maternal glucose levels and increased fetal growth are well established and independent relationships with maternal weight, weight gain and insulin resistance are also observed. The relative roles of lipolysis and glucose production in the determination of these observations remain unclear. DESIGN: We examined, through detailed physiological studies, the relationship between maternal late gestational energy substrate production (glucose and glycerol), maternal weight and weight gain, and estimated fetal size in the third trimester...
April 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28433733/factors-influencing-repeated-teenage-pregnancy-a-review-and-meta-analysis
#3
REVIEW
Joemer C Maravilla, Kim S Betts, Camila Couto E Cruz, Rosa Alati
OBJECTIVE: Existing evidence of predictors of repeated teenage pregnancy (RTP) has not been rigorously assessed. This systematic review provides a comprehensive evaluation of protective and risk factors associated with RTP through a meta-analytical consensus. DATA SOURCES: Pubmed, EMBASE, CINAHL, ProQuest, PsychINFO, ScienceDirect, Scopus and Web of Science databases, from 1997 to 2015; and reference list of other relevant research papers and related reviews. STUDY ELIGIBILITY CRITERIA: Eligibility criteria included 1) epidemiological studies which analysed factors associated with repeated pregnancy or birth among adolescents under 20 years of age who were nulliparous or experienced at least one pregnancy; 2) experimental studies with an observational component adjusted for the intervention...
April 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28432626/temporal-trends-of-lipophilic-persistent-organic-pollutants-in-serum-from-danish-nulliparous-pregnant-women-2011-2013
#4
Christian Bjerregaard-Olesen, Manhai Long, Mandana Ghisari, Bodil H Bech, Ellen A Nohr, Niels Uldbjerg, Tine B Henriksen, Jørn Olsen, Eva C Bonefeld-Jørgensen
The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28429514/maternal-metabolic-adaptations-to-pregnancy-among-young-women-in-cebu-philippines
#5
Ruby L Fried, Nanette L Mayol, Thom W McDade, Christopher W Kuzawa
OBJECTIVES: Evidence that fetal development has long-term impacts on health has increased interest in maternal-fetal nutrient exchange. Although maternal metabolism is known to change during gestation to accommodate fetal nutrient demands, little is known about these modifications outside of a Western, clinical context. This study characterizes maternal metabolic adaptations to pregnancy, and their associations with offspring birth weight (BW), among women living in the Philippines. METHODS: Fasting glucose, triglycerides, insulin, leptin, and adiponectin were assessed in 808 participants in the Cebu Longitudinal Health and Nutrition Survey (Metropolitan Cebu, Philippines)...
April 21, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28426453/indications-for-mode-of-delivery-in-pregnant-women-with-inflammatory-bowel-disease
#6
Kristin E Burke, Miriam J Haviland, Michele R Hacker, Scott A Shainker, Adam S Cheifetz
BACKGROUND: Reasons for the increased incidence of cesarean delivery among women with inflammatory bowel disease remain unclear. We assessed cesarean delivery incidence and factors influencing mode of delivery in women with inflammatory bowel disease. METHODS: We performed a 10-year retrospective cohort study of nulliparous women who delivered a singleton infant at our institution. We compared the risk of each mode of delivery in women with Crohn's disease and ulcerative colitis with women without inflammatory bowel disease...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28425307/epidural-fentanyl-does-not-affect-cervical-dilation-and-progress-of-first-stage-of-vaginal-delivery-a-randomized-double-blind-study
#7
Chryssoula Staikou, Theodoros Kalampokas, Emmanouil Kalampokas, Sophia Vassiloglou, Anteia Paraskeva
OBJECTIVE: Local anesthetics combined with opioids are commonly used in labor epidural analgesic schemes. We investigated if the addition of fentanyl to epidural ropivacaine can affect cervical dilation and progress of vaginal delivery. METHODS: Sixty-two nulliparous parturients were randomized to receive epidurally 8ml ropivacaine 0.2% combined with fentanyl 20μg (F/R-group, n = 31) or with normal saline 0.4ml (R-group, n = 31), every hour. Rescue doses of 5ml ropivacaine 0...
April 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28425156/universal-versus-selective-ultrasonography-to-screen-for-large-for-gestational-age-infants-and-associated-morbidity
#8
Ulla Sovio, Alexandros A Moraitis, Hilary S Wong, Gordon C S Smith
OBJECTIVE: To compare the diagnostic effectiveness of selective versus universal ultrasonography as a screening test for large for gestational age (LGA) infants, and to determine whether previously described ultrasonic markers of excessive fetal growth could identify which suspected LGA fetuses were at increased risk of neonatal morbidity. METHODS: We analysed data from a prospective cohort study of nulliparous women, the Pregnancy Outcome Prediction study. All women had clinically indicated scans as per routine care...
April 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28425003/validation-of-the-persian-version-of-the-daily-spiritual-experiences-scale-dses-in-pregnant-women-a-proper-tool-to-assess-spirituality-related-to-mental-health
#9
Mohsen Saffari, Hossein Amini, Zarindokht Sheykh-Oliya, Amir H Pakpour, Harold G Koenig
Assessing spirituality in healthy pregnant women may lead to supportive interventions that will improve their care. A psychometrically valid measure such as the Daily Spiritual Experiences Scale (DSES) may be helpful in this regard. The current study sought to adapt a Persian version of DSES for use in pregnancy. A total of 377 pregnant women were recruited from three general hospitals located in Tehran, Iran. Administered scales were the DSES, Duke University Religion Index, Santa Clara Strength of Religious Faith scale, and Depression Anxiety Stress Scale, as well as demographic measures...
April 19, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28423605/pregnancy-at-early-age-is-associated-with-a-reduction-of-progesterone-responsive-cells-and-epithelial-wnt-signaling-in-human-breast-tissue
#10
Simone Muenst, Robert Mechera, Silvio Däster, Salvatore Piscuoglio, Charlotte K Y Ng, Fabienne Meier-Abt, Walter P Weber, Savas D Soysal
BACKGROUND: Pregnancy at early age is the most significant modifiable factor which consistently decreases lifetime breast cancer risk. However, the underlying mechanisms haven't been conclusively identified. Studies in mice suggest a reduction in progesterone-receptor (PR) sensitive epithelial cells as well as a downregulation of the Wnt signaling pathway as being one of the main mechanisms for the protective effect of early pregnancy. The aim of our study was to validate these findings in humans...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421655/reduction-of-preterm-birth-rates-starts-at-preconception
#11
M A Oudijk
Obesity, in the absence of other chronic disease, is associated with preterm birth (PTB) according to the article by Kim et al. Perhaps their most interesting finding is that obesity is positively associated in nulliparous women with extremely PTB rates (birth at < 28 weeks of gestation), both spontaneous and indicated. This extreme PTB group specifically contributes to neonatal morbidity and mortality. This article is protected by copyright. All rights reserved.
April 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28417155/pelvic-floor-symptoms-and-quality-of-life-changes-during-first-pregnancy-a-prospective-cohort-study
#12
Rebecca G Rogers, Cara Ninivaggio, Kelly Gallagher, A Noelle Borders, Clifford Qualls, Lawrence M Leeman
INTRODUCTION AND HYPOTHESIS: We describe pelvic floor function in nulliparous pregnant women. MATERIALS AND METHODS: Nulliparous midwifery patients completed the Incontinence Severity Index (ISI), Pelvic Floor Impact Questionnaire (PFIQ-7), Wexner Fecal Incontinence Scale (W), and answered questions about sexual activity and perineal pain at baseline during the first (T1), second (T2), or third trimester (T3) and repeated in late T3. They also underwent a Pelvic Organ Prolapse Quantification (POP-Q) exam at their baseline visit...
April 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28412085/in-vivo-evidence-of-significant-levator-ani-muscle-stretch-on-mr-images-of-a-live-childbirth
#13
Nikhil Sindhwani, Christian Bamberg, Nele Famaey, Geertje Callewaert, Joachim W Dudenhausen, Ulf Teichgräber, Jan Deprest
OBJECTIVE: Vaginal childbirth is believed to be a significant risk factor for the development of pelvic floor dysfunction later in life. Previous studies have explored the use of medical imaging and simulations of childbirth to determine the stretch in the levator ani muscle. Bamberg et al, 2012, have recorded MR images of a live childbirth of a 24 year old woman giving birth vaginally for the second time, using a 1.0 Tesla open high-field scanner. Our objective was to determine the stretch ratios in the levator muscle using these MR images of live childbirth...
April 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28410971/the-association-between-parity-and-inflammation-among-mexican-american-women-of-reproductive-age-varies-by-acculturation-level-results-of-the-national-health-and-nutrition-examination-survey-1999-2006
#14
Natalya Rosenberg, Martha L Daviglus, Holli A DeVon, Chang Gi Park, Kamal Eldeirawi
INTRODUCTION: Parity and acculturation are linked with cardiometabolic risk. Their joint association with cardiometabolic health among Mexican-American women is less established, even though immigrant Mexican-American women have the highest fertility rate in the United States. We examined the modifying role of acculturation on the association of parity with a cardiometabolic risk biomarker, C-reactive protein (CRP). METHODS: Participants (n = 1,002) were women of Mexican background, ages 16 to 39 years, in the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2006...
April 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28403959/impact-of-the-french-3rd-and-4th-generation-pill-scare-in-women-seeking-termination-of-pregnancy
#15
O Caillot, M Aubry, S Duros, L Boyer, C Van Valenberg, J Levêque, V Lavoué
INTRODUCTION: The aim of this study was to evaluate changes in the contraceptive profile of women seeking termination of pregnancy following the debate on 3rd and 4th generation pills in France in 2012. MATERIALS AND METHODS: Single-center case-control study comparing the attitude to contraception before (between 02/15/2012 and 07/16/2012) and after the debate (between 02/25/2013 and 06/24/2013). RESULTS: A total of 291 patients consulted before and 601 after the debate...
January 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403891/foley-catheter-for-cervical-priming-in-induction-of-labour-at-university-obstetrics-unit-colombo-sri-lanka-a-clinical-audit-with-a-patient-satisfaction-survey
#16
M Patabendige, A Jayawardane
BACKGROUND: Intracervical insertion of a Foley catheter (FC) has shown to be a safe, effective and relatively feasible mechanical method of cervical priming in induction of labour (IOL). We evaluated indications, effectiveness, patient acceptability and outcomes of FC use in IOL adhering to the ward protocol in our unit. METHODS: A clinical audit with a patient satisfaction survey conducted between July and September 2013 in University Obstetric Unit, Colombo, Sri Lanka...
April 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28403411/comparison-of-bioreactance-and-echocardiographic-non-invasive-cardiac-output-monitoring-and-myocardial-function-assessment-in-primagravida-women
#17
A Doherty, A El-Khuffash, C Monteith, L McSweeney, C Breatnach, E Kent, E Tully, F Malone, P Thornton
Background.: Non-invasive cardiac output monitoring (NICOM) using bioreactance (BRT) in pregnancy is gaining interest but lacks validation. We compared simultaneous cardiac output (CO) measurements obtained using the NICOM ® (BRT-CO) and echocardiography (echo-CO), and assessed the relationship between maternal characteristics and myocardial performance. Methods.: Paired stroke volume (SV) and CO readings were obtained using NICOM ® and echocardiography, in a group of healthy nulliparous women throughout a 15 min period...
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28401024/inhibition-of-stat3-signaling-blocks-obesity-induced-mammary-hyperplasia-in-a-mouse-model
#18
Jeong Won Park, Li Zhao, Mark C Willingham, Sheue-Yann Cheng
Compelling epidemiologic evidence indicates that obesity is a risk factor for human cancers, including breast. However, molecular mechanisms by which obesity could contribute to the development of breast cancer remain unclear. To understand the impact of obesity on breast cancer development, we used a mutant mouse that expresses a mutated thyroid hormone receptor β (denoted as PV) with haplodeficiency of the Pten gene (Thrb(PV/PV)Pten(+/-) mice). We previously showed that adult nulliparous female Thrb(PV/PV)Pten(+/-) mice developed extensive mammary hyperplasia and breast tumors...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28399853/the-anti-cancer-effects-of-tualang-honey-in-modulating-breast-carcinogenesis-an-experimental-animal-study
#19
Sarfraz Ahmed, Nor Hayati Othman
BACKGROUND: Honey has been shown to have anti-cancer effects, but the mechanism behind these effects is not fully understood. We investigated the role of Malaysian jungle Tualang honey (TH) in modulating the hematological parameters, estrogen, estrogen receptors (ER1) and pro and anti-apoptotic proteins expression in induced breast cancer in rats. METHODS: Fifty nulliparous female Sprague-Dawley rats were used and grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3 and 4 received daily doses of 0...
April 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28398665/both-a-frameshift-and-a-missense-mutation-of-the-stra6-gene-observed-in-an-infant-with-the-matthew-wood-syndrome
#20
Samantha Sadowski, Nicolas Chassaing, Zuzanna Gaj, Ewa Czichos, Jan Wilczynski, Dorota Nowakowska
BACKGROUND: The Matthew-Wood syndrome is associated with mutations of the STRA6 gene. It combines a pulmonary agenesis/hypoplasia; microphthalmia/anophthalmia; congenital cardiac, digestive, and urogenital malformations; and diaphragmatic defects. CASE: A 23-year-old nulliparous woman was referred to our center after a fetal ultrasound examination at 26 weeks of pregnancy revealed an abnormal head shape, a heart malformation, multiple cysts in both kidneys, and dilated ureters...
March 1, 2017: Birth Defects Res
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