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Skin hyperpigmentation

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https://www.readbyqxmd.com/read/29469763/unusually-extensive-scalp-ulcerations-manifested-in-pemphigus-erythematosus
#1
Neha Chandan, Eden P Lake, Lawrence S Chan
Senear-Usher Syndrome, or pemphigus erythematosus, is an autoimmune skin blistering disorder with an overlapping clinical presentation of pemphigus foliaceus and lupus erythematosus. Lesions typically involve the scalp, face, and upper chest or back. This case study focuses on a patient who presentedwith progressive scalp ulcers, hyperpigmentation, and eroded plaques with overlying hemorrhagic crust. Pemphigus erythematosus was diagnosedwith direct immunofluorescence, demonstrating immunoglobulin G and complement deposition both intercellularly and at the dermoepidermal junction...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29464168/treatment-strategies-for-hypopigmentation-in-the-context-of-burn-hypertrophic-scars
#2
Bonnie C Carney, Jacqueline P McKesey, Dean S Rosenthal, Jeffrey W Shupp
Dyspigmentation in burn scars can contribute to the development of psychosocial complications after injury and can be detrimental to social reintegration and quality of life for burn survivors. Although treatments for skin lightening to treat hyperpigmentation have been well reviewed in the literature, skin-darkening strategies to treat hypopigmentation have not. The following potential treatment options in the context of burn hypertrophic scar will be discussed: use of the melanocyte-keratinocyte transplantation procedure, use of ectopic synthetic analogues of alpha-melanocyte stimulating hormone to initiate melanogenesis, and use of FK506 to induce melanogenesis...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29460390/safety-assessment-biological-effects-and-mechanisms-of-myrica-rubra-fruit-extract-for-anti-melanogenesis-anti-oxidation-and-free-radical-scavenging-abilities-on-melanoma-cells
#3
Lih-Jeng Juang, Xiang-Yu Gao, Shou-Ting Mai, Cheng-Hung Lee, Ming-Chung Lee, Chao-Ling Yao
OBJECTIVE: Currently, the cosmetic and medical industries are paying considerable attention to solve or prevent skin damage or diseases, such as hyperpigmentation and oxidation and free radical damage. In this study, the effective compounds in Myrica rubra fruit were extracted and studied the biological effects of these M. rubra fruit extracts. METHODS: In this study, we extracted M. rubra fruit using solutions with various ratios of water to ethanol (100:0, 50:50, 5:95) and studied the anti-melanogenesis, anti-oxidation and radical scavenging effects of these M...
February 20, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29452029/intense-pulsed-light-is-effective-in-treating-postburn-hyperpigmentation-and-telangiectasia-in-chinese-patients
#4
Na Li, Juntao Han, Dahai Hu, Jing Cheng, Hongtao Wang, Yunchuan Wang, Xuekang Yang, Jiaqi Liu, Ting Li, Wenli Zhao
Intense pulsed light (IPL) has been used to treat postinflammatory hyperpigmentation and telangiectasia in Fitzpatrick type I -II skin. However, its therapeutic effects after superficial second-degree burns in Asian populations with Fitzpatrick type III-IV skin are uncertain. Thirty-five Han Chinese patients with facial or hand hyperpigmentation and telangiectasia due to second-degree fire burns received treatment with IPL. Each patient underwent 2-6 treatments over 3-5 weeks. The laser wavelength was 560-615 nm...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29445569/glutathione-for-skin-lightening-a-regnant-myth-or-evidence-based-verity
#5
Sidharth Sonthalia, Abhijeet K Jha, Aimilios Lallas, Geraldine Jain, Deepak Jakhar
The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a "wonder" drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#6
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29438574/protective-effects-of-an-extract-of-the-freshwater-microalga-scenedesmus-rubescens-on-uv-irradiated-skin-cells
#7
Remo Campiche, Petra Sandau, Elke Kurth, Marco Massironi, Dominik Imfeld, Rolf Schuetz
BACKGROUND: Skin aging results from intrinsic but also extrinsic factors of which UV-irradiation is a main cause. It is hence of interest to have means to protect skin from UV -irradiation induced damage. We selected an extract of the freshwater microalga Scenedesmus rubescens and assessed its potential to protect skin from photoaging caused by UV-irradiation. METHODS: Skin cells in-vitro and ex-vivo were analyzed for markers of UV-irradiation induced photodamage such as decreased viability, decreased collagen content, hyperpigmentation, and sunburn cells...
February 13, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29434427/picosecond-laser-treatment-for-tattoos-and-benign-cutaneous-pigmented-lesions-secondary-publication
#8
REVIEW
Kenichiro Kasai
Background and aims: The selective removal of tattoos and benign cutaneous pigmented lesions with laser energy evolved rapidly with the development of the nanosecond-domain Q-switched laser (ns-laser). Recently, however, a series of picosecond-domain lasers (ps-lasers) with pulsewidths less than 1 ns has become commercially available, enabling more efficient and faster removal of pigmented lesions in the field of dermatologic laser surgery. Rationale behind the ps-laser: The efficacy of the ns-laser depended on the theory of selective photothermolysis, whereby an extremely short pulse width was delivered less than the thermal relaxation time (TRT) of a target...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29431372/pigmentation-disorders-diagnosis-and-management
#9
Scott Plensdorf, Maria Livieratos, Nabil Dada
Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Appropriate dermatologic history, skin examination, and skin biopsy, when appropriate, can help exclude melanoma and its precursors. In addition to addressing the underlying condition, hyperpigmentation is treated with topical agents, chemical peels, cryotherapy, light or laser therapy, or a combination of these methods...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29431228/efficacy-of-mas063dp-lotion-vs-0-02-triamcinolone-acetonide-lotion-in-improving-post-ablative-fractional-co-2-laser-resurfacing-wound-healing-a-split-face-triple-blinded-randomized-controlled-trial
#10
Suparuj Lueangarun, Therdpong Tempark
Proven as effective acne scar treatment, ablative fractional carbon dioxide (AFCO 2 ) laser requires post-laser wound healing care. MAS063DP is a multicomponent nonsteroidal anti-inflammatory moisturizer for effective post-laser treatment. This study compares the efficacy of MAS063DP and 0.02% triamcinolone acetonide (TA) lotion for post-laser wound healing and complications. A split-face, triple-blinded, clinical study was performed in 16 patients, aged 20-50 years, receiving AFCO 2 on both sides of the face, with MAS063DP on one side and 0...
February 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29430989/nk1r-5-ht1ar-interaction-is-related-to-the-regulation-of-melanogenesis
#11
Huali Wu, Yucheng Zhao, Qiaoling Huang, Minxuan Cai, Qi Pan, Mengsi Fu, Xiaohong An, Zhenjiang Xia, Meng Liu, Yu Jin, Ling He, Jing Shang
Substance P (SP) is a candidate mediator along the brain-skin axis and can mimic the effects of stress to regulate melanogenesis. Previously, we and others have found that the regulation of SP for pigmentary function was mediated by neurokinin 1 receptor (NK1R). Emerging evidence has accumulated that psychologic stress can induce dysfunction in the cutaneous serotonin 5-hydroxytryptamine (5-HT)-5-HT1A/1B receptor system, thereby resulting in skin hypopigmentation. Moreover, NK1R and 5-HTR (except 5-HT3) belong to GPCR...
February 7, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29427586/inhibition-of-human-tyrosinase-requires-molecular-motifs-distinctively-different-from-mushroom-tyrosinase
#12
Tobias Mann, Wolfram Gerwat, Jan Batzer, Kerstin Eggers, Cathrin Scherner, Horst Wenck, Franz Stäb, Vincent J Hearing, Klaus-Heinrich Röhm, Ludger Kolbe
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target to inhibit hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibitory concentration (IC50) in the millimolar range, while kojic acid showed a weak efficacy (IC50 > 400 μM)...
February 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29417559/imatinib-induced-diffuse-hyperpigmentation-of-the-oral-mucosa-the-skin-and-the-nails-in-a-patient-affected-by-chronic-myeloid-leukemia-report-of-a-case-and-review-of-the-literature
#13
REVIEW
Francesca Di Tullio, Victor D Mandel, Rosa Scotti, Claudia Padalino, Giovanni Pellacani
BACKGROUND: Imatinib mesylate is a tyrosine-kinase inhibitor used as the first-line treatment in chronic myeloid leukemia patients, but it is also indicated for other hematological diseases and solid tumors. Imatinib treatment is often associated with hypopigmentation, but only a few cases of hyperpigmentation are described in literature. METHODS: We are reporting the first case of imatinib-related hyperpigmentation involving the oral mucosa, skin, and nails in a patient affected by chronic myeloid leukemia and treated with imatinib since 2002...
February 8, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29404955/comparative-study-of-glyceryl-behenate-or-polyoxyethylene-40-stearate-based-lipid-carriers-for-trans-resveratrol-delivery-development-characterization-and-evaluation-of-the-in-vitro-tyrosinase-inhibition
#14
Naiara Fachinetti, Roberta Balansin Rigon, Josimar O Eloy, Mariana Rillo Sato, Karen Cristina Dos Santos, Marlus Chorilli
Trans-resveratrol (RSV) is a natural compound with several properties, such as the ability to inhibit the tyrosinase enzyme, with potential application as a skin-lightning agent and for the treatment of skin disorders associated with hyperpigmentation and melanogenesis. However, the drug faces several drawbacks which altogether limit its therapeutic application. Thus, drug loading into nanocarriers emerge as an alternative to circumvent these problems. Herein, nanostructured lipid carriers (NLCs) have been employed for RSV encapsulation, with comparison of two different lipids, glyceryl behenate (more hydrophobic), and polyoxyethylene 40 (PEG 40) stearate...
February 5, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29404508/sofosbuvir-induced-steven-johnson-syndrome-in-a-patient-with-hepatitis-c-virus-related-cirrhosis
#15
Nipun Verma, Shreya Singh, Gitesh Sawatkar, Virendra Singh
Sofosbuvir is an imperative drug used in treatment regimens for hepatitis C virus (HCV). It is considered relatively safe with fewer adverse effects than other treatments. Here, we report a rare and potentially serious, dermatologic, adverse effect following the use of sofosbuvir. A 35-year-old man with genotype 3-related HCV cirrhosis presented with decompensated ascites and jaundice following 7 weeks of therapy with peginterferon alpha-2a and oral ribavirin. After peginterferon withdrawal and stabilization, oral sofosbuvir and ribavirin were started; 10 days later, he developed itching over the trunk and legs, followed by multiple papules and vesicles over an erythematous base...
January 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29401124/skin-burn-associated-with-photochemotherapy
#16
Emre Gazyakan, Christoph Hirche, Holger Engel, Ulrich Kneser, Amir K Bigdeli
OBJECTIVE: psoralen and ultraviolet A (PUVA) phototherapy (PT) has become a standard treatment for several severe skin diseases. Photosensitization is done by oral psoralen intake. In minor cases, PUVA can lead to skin changes like erythema and hyperpigmentation. However, it can also lead to severe burn injuries when exposed to extensive UV light. This makes the treatment in a burn center inevitable. METHODS: We report the clinical observation of a 38-year-old man presenting with an extensive burn injury caused by sun tanning after PUVA PT...
February 2, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29399291/sageretia-thea-fruit-extracts-rich-in-methyl-linoleate-and-methyl-linolenate-downregulate-melanogenesis-via-the-akt-gsk3%C3%AE-signaling-pathway
#17
Gyeong-A Ko, Sabina Shrestha, Somi Kim Cho
BACKGROUND/OBJECTIVES: Sageretia thea is traditionally used as a medicinal herb to treat various diseases, including skin disorders, in China and Korea. This study evaluated the inhibitory effect of Sageretia thea fruit on melanogenesis and its underlying mechanisms in B16F10 mouse melanoma cells. The active chemical compounds in anti-melanogenesis were determined in Sageretia thea. MATERIALS/METHODS: Solvent fractions from the crude extract were investigated for anti-melanogenic activities...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29399257/oxygeneo%C3%A2-a-unique-three-in-one-treatment-of-exfoliation-infusion-and-oxygenation-via-the-bohr-effect-and-tripollar%C3%A2-radiofrequency-for-skin-rejuvenation
#18
Deanna Diaz, Metavee Boonsiri, Joyce Okawa, Denise Dekranes, Chérie M Ditre
Background: Oxygenation of the skin has been shown to improve cell growth and cell biosynthesis, which can subsequently improve the skin's appearance.1,2 However, the majority of skin oxygenation techniques are invasive.3,4 A noninvasive skin oxygenation treatment, also known as a carboxytherapy facial, with TriPollar® radiofrequency device has emerged called OxyGeneo™, which is provided by the geneO+™ skin care platform (Pollogen Ltd., Tel Aviv, Israel). Objective: This study addresses the clinical effectiveness of the aforementioned noninvasive skin oxygenation treatment on skin texture, fine lines/wrinkles, and skin pigmentation over an eight-week time period...
November 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29386836/asymptomatic-hyperpigmentation-without-preceding-inflammation-as-a-clinical-feature-of-citrus-fruits-induced-phytophotodermatitis
#19
Ji Young Choi, Shinwon Hwang, Si-Hyung Lee, Sang Ho Oh
Phytophotodermatitis is a condition that occurs by contact with plants containing phototoxic agents such as furocoumarins and psoralens with subsequent ultraviolet exposure. Phytophotodermatitis typically presents as sharply defined erythematous patches with occasional blistering, sometimes accompanied with pain or itching sensation. In some cases, however, sudden appearance of asymptomatic hyperpigmentation can be the only clinical finding of phytophotodermatitis. Here, we present two patients with sudden development of asymptomatic pigmentation on their hand without preceding inflammation by the contact with citrus fruits containing photosensitizers and subsequent exposure to strong sunlight...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29386416/childhood-cerebral-x-linked-adrenoleukodystrophy-with-atypical-neuroimaging-abnormalities-and-a-novel-mutation
#20
M Muranjan, S Karande, S Sankhe, S Eichler
Childhood cerebral X-linked adrenoleukodystrophy (XALD) typically manifests with symptoms of adrenocortical insufficiency and a variety of neurocognitive and behavioral abnormalities. A major diagnostic clue is the characteristic neuroinflammatory parieto-occipital white matter lesions on magnetic resonance imaging. This study reports a 5-year 10-month old boy presenting with generalized skin hyperpigmentation since 3 years of age. Over the past 9 months, he had developed right-sided hemiparesis and speech and behavioral abnormalities, which had progressed over 5 months to bilateral hemiparesis...
January 2018: Journal of Postgraduate Medicine
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