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Skin hyperpigmentation

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https://www.readbyqxmd.com/read/28101465/nanostructured-lipid-carrier-for-topical-application-of-n-acetyl-glucosamine
#1
Lavin Aliasgharlou, Saeed Ghanbarzadeh, Hamideh Azimi, Mohammad Hossein Zarrintan, Hamed Hamishehkar
: Purpose: Hyperpigmentation occurs when melanin is overproduced in certain spots on the skin and is one of the most challenging skin conditions to treat. Although it is usually harmless, for cosmetic reasons, it is dreadfully bothersome to those who undergo it. It was reported that N-acetyl-glucosamine (NAGA) prevents melanin synthesis and alters the expression of numerous genes related to pigmentation. In spite of these advantages, NAGA cannot be employed in topical formulations due to its extremely polar characteristics...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28099615/do-you-know-this-syndrome-dyspigmentation-along-the-blaschko-lines-caused-by-trisomy-7-mosaicism
#2
Miguel Pinto de Gouveia, Inês Coutinho, Vera Teixeira, Renata d'Oliveira, Margarida Venâncio, Ana Moreno
Dyspigmentation along the Blaschko lines is strongly suggestive of a mosaic skin disorder. We report a 9-year-old male patient who presented with swirls and streaks of both hypo and hyperpigmentation involving the entire body. Additionally, he had hypertrichosis, musculoskeletal and minor neurodevelopment abnormalities but no intellectual disability. Cultured fibroblast displayed trisomy 7 mosaicism, which can explain this pigmentary phenotype. Widespread dyspigmentation associated with involvement of other organs should prompt systemic examination to detect additional anomalies and genetic evaluation should be considered, even with normal fetal karyotype...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28097306/universal-trichloroacetic-acid-peel-technique-for-light-and-dark-skin
#3
Nabil Fanous, Shadi Zari
Importance: Despite their great potential, medium and deep trichloroacetic acid peels are underused in light-skinned patients and are rarely used in darker-skinned patients because of the widespread fear of pigmentary complications and scarring. This concern has led many physicians to opt for the use of lighter types of peels (glycolic acid peel, Jessner peel, etc) and different lasers and intense light technologies. Trichloroacetic acid peels have been described in numerous publications...
January 12, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28095579/development-and-clinical-assessment-of-a-comprehensive-product-for-pigmentation-control-in-multiple-ethnic-populations
#4
Elizabeth T Makino, Kuniko Kadoya, Monya L Sigler, Peter D Hino, Rahul C Mehta
BACKGROUND: Pigmentary changes in people of different ethnic origins are controlled by slight variations in key biological pathways leading to different outcomes from the same treatment. It is important to develop and test products for desired outcomes in varying ethnic populations. OBJECTIVES: To develop a comprehensive product (LYT2) that affects all major biological pathways controlling pigmentation and test for clinical efficacy and safety in different ethnic populations...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095558/clinical-evaluation-of-a-4-hydroquinone-1-retinol-treatment-regimen-for-improving-melasma-and-photodamage-in-fitzpatrick-skin-types-iii-vi
#5
Marta I Rendon, Sylvia Barkovic
The bene ts of monotherapy with hydroquinone for melasma and retinoids for photodamaged skin is well established. Here we report results of a hydroquinone skincare regimen designed for melasma treatment combined with a cosmetic retinol cream on subjects presenting with both melasma and facial photodamage in a 24-week study. Improvement in melasma and photodamage ef cacy pa- rameters of melasma pigmentation intensity and melasma area and severity index (MASI), as well as overall photodamage and mottled hyperpigmentation were found by week 4, the rst post-baseline time point...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095556/combination-therapy-for-acne-scarring-personal-experience-and-clinical-suggestions
#6
Lucija Kroepfl, Jason J Emer
Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095549/treatment-of-facial-photodamage-with-mass-market-topical-products-vs-non-ablative-fractional-laser
#7
Hilary Reich, Irmina Wallander, Lacie Schulte, Molly Goodier, Brian Zelickson
METHODS: In this split-face, evaluator-blinded study, 18 subjects were randomly assigned to receive either the SSR or NFL treatments on each side of the face. For the SSR facial sides subjects followed two morning-evening regimens. On the NFL sides subjects were treated 3 times with the 1927-nm laser at 4-week intervals. Three physician evaluators were asked to rate hyperpigmentation, global photoaging, and ne lines and wrinkles for each side of the face at baseline and at 3 months using a 5-point scale...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28050350/diffuse-skin-hyperpigmentation-associated-with-chronic-minocycline-use-in-a-patient-with-prosthetic-joint-infection
#8
Hadi Berbari, Elie F Berbari, Irene G Sia
Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors associated with minocycline-induced cutaneous pigmentation (MICH) will be reviewed.
2017: IDCases
https://www.readbyqxmd.com/read/28032173/clinical-outcomes-and-complications-associated-with-fractional-lasers-a-review-of-730-patients
#9
Steven R Cohen, Ashley Goodacre, Soobin Lim, Jennifer Johnston, Cory Henssler, Brian Jeffers, Ahmad Saad, Tracy Leong
BACKGROUND: Fractional lasers were introduced to provide increased safety, while maintaining high efficacy and patient satisfaction. Patients with virtually all Fitzpatrick skin types could be safely treated using a wide spectrum of wavelengths and a broad array of skin conditions, and aging could be addressed. Although safety studies have been reported for ablative CO2 and erbium lasers, surprisingly few data are available on adverse events and complications associated with fractional lasers...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28029781/aryl-hydrocarbon-receptor-activation-contributes-to-benzanthrone-induced-hyperpigmentation-via-modulation-of-melanogenic-signaling-pathways
#10
Sabiya Abbas, Shamshad Alam, Krishna P Singh, Mahadeo Kumar, Shailendra K Gupta, Kausar M Ansari
Benzanthrone (BA), an oxidized polycyclic aromatic hydrocarbon (PAH), has been found to be a potential health threat to occupational workers involved in dye manufacturing factories. It has been observed that occupational workers become exposed to BA either during manufacturing, pulverization, or storage and developed various kinds of skin diseases like contact dermatitis, itching, erythema, roughness, and foremost, hyperpigmentation. It has been shown that some environmental organic pollutants (POPs) like dioxins, furans, and polychlorinated biphenyls (PCBs) may act as ligands for the aryl hydrocarbon receptor (AhR) and regulate hyperpigmentation...
January 12, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28017864/modifying-effects-of-carboxyl-group-on-the-interaction-of-recombinant-s100a8-a9-complex-with-tyrosinase
#11
Fatemeh NematiNiko, Koorosh Goodarzvand Chegini, Hamideh Asghari, Abbas Amini, Nematollah Gheibi
Tyrosinase is a determinant enzyme for modulating melanin production as its abnormal activity can result in an increased amount of melanin. Reduction of tyrosinase activity has been targeted for preventing and healing hyperpigmentation of skin, such as melanoma and age related spots. The aim of this systematic study is to investigate whether recombinant S100A8/A9 and its modified form reduce the activity of mushroom tyrosinase (MT) through changing its structure. Recombinant His-Tagged S100A8 and S100A9 are expressed in Escherichia coli BL21 (DE3) and modified using Woodward's reagent K which is a carboxyl group modifier...
December 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28009316/-efficacy-of-combined-use-of-antioxidative-and-phototherapy-in-the-treatment-of-vitiligo
#12
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, Ts Tsiskarishvili, L Chitanava
Despite of numerous investigations, carried out practically in all countries of the world for the study of vitiligo and the search for its new effective therapies, pathogenic mechanisms of vitiligo are still poorly understood, and the proposed treatments are not perfect. One of the most accepted theories of the pathogenesis of vitiligo is an oxidative stress theory, according to which a series of biochemical anomalies cause oxidative stress, leading to accumulation of melanocytotoxic substances and inhibition of natural processes of detoxification with subsequent destruction of melanocytes in vitiligo focus...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28003921/bullous-dermatosis-in-an-end-stage-renal-disease-patient-a-case-report-and-literature-review
#13
Zeenat Yousuf Bhat, Marwan Abu Minshar, Nashat Imran, Andrew Thompson, Yahya Osman Malik
Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27999648/comparison-of-long-pulsed-alexandrite-laser-and-topical-tretinoin-ammonium-lactate-in-axillary-acanthosis-nigricans-a-case-series-of-patients-in-a-before-after-trial
#14
Amirhoushang Ehsani, Pedram Noormohammadpour, Azadeh Goodarzi, Mostafa Mirshams Shahshahani, Seyede Pardis Hejazi, Elhamsadat Hosseini, Arghavan Azizpour
BACKGROUND: Acanthosis nigricans (AN) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. Treatment of AN is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. The goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for treatment of axillary-AN. METHODS: Fifteen patients with bilateral axillary-AN were studied in Razi Hospital, Tehran, Iran...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27999131/melanoderma-uncommon-presentation-of-a-common-condition
#15
Priyadarshini Gunaseelan, Sarveswari Narasingarajan, Shriraam Mahadevan
A 64-year-old man presented with blackish pigmentation of skin and tongue for more than 2 years that did not improve with local remedies. He had no history of comorbid medical or surgical illnesses. General examination showed severe hyperpigmentation of skin and mucosa and also showed anaemia. Systemic examination was unremarkable except for Romberg sign and mild hyperreflexia. Adrenal insufficiency was ruled out by normal cortisol levels and haemogram showed macrocytosis with hypersegmented neutrophils suggestive of severe vitamin B12 deficiency which confirmed by low serum B12 levels...
December 20, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27987313/assessment-of-egf-receptor-ligand-expression-in-gastric-carcinoma-and-in-lesional-skin-of-paraneoplastic-acanthosis-nigricans-a-case-report
#16
E Moreno-Artero, E Querol, M Ivars, I Sola, R Pío, A España
A 70-year-old male presented with hyperpigmentation and thickening of the skin, especially on the neck, axillae and groin, papillomatous thickening of the mucosa of the mouth and lips which presented a "stone path-like" morphology and cutaneous and palmoplantar thickening with marked accentuation of skin dermatoglyphic patterns ("tripe-palms") (Fig 1). The lesions had started one year previously and were accompanied by generalized pruritus, intense asthenia on mild exertion and weight loss. This article is protected by copyright...
December 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27983977/inhibition-of-tyrosinase-activity-and-melanin-production-by-the-chalcone-derivative-1-2-cyclohexylmethoxy-6-hydroxy-phenyl-3-4-hydroxymethyl-phenyl-propenone
#17
Byung-Hak Kim, Kyoung Chan Park, Jeong Ho Park, Chung Gi Lee, Sang-Kyu Ye, Jung Youl Park
Abnormal accumulation of melanin pigments in the skin can be lead to hyperpigmentation disorders and melanoma. Melanin biosynthesis is ultimately regulated by the rate-limiting enzyme tyrosinase. In the present study, we synthesized chalcone derivatives and identified 1-(2-cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone (chalcone-21) as an anti-melanogenic substance in B16F10 melanoma cells. Chalcone-21 strongly inhibited cellular melanin production and tyrosinase activity in B16F10 melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH) or protoporphyrin IX...
October 27, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27982166/randomized-trial-of-radiofrequency-ablation-versus-conventional-surgery-for-superficial-venous-insufficiency-if-you-don-t-tell-they-won-t-know
#18
Cynthia de Almeida Mendes, Alexandre de Arruda Martins, Juliana Maria Fukuda, José Ben-Hur Ferraz Parente, Marco Antonio Soares Munia, Alexandre Fioranelli, Marcelo Passos Teivelis, Andrea Yasbek Monteiro Varella, Roberto Augusto Caffaro, Sergio Kuzniec, Nelson Wolosker
OBJECTIVES: This study compared radiofrequency ablation versus conventional surgery in patients who had not undergone previous treatment for bilateral great saphenous vein insufficiency, with each patient serving as his own control. METHOD: This was a randomized controlled trial that included 18 patients and was carried out between November 2013 and May 2015. Each of the lower limbs of each patient was randomly assigned to undergo either radiofrequency ablation or conventional surgery...
November 1, 2016: Clinics
https://www.readbyqxmd.com/read/27981619/familial-progressive-hyperpigmentation-cutaneous-mastocytosis-and-gastrointestinal-stromal-tumor-as-clinical-manifestations-of-mutations-in-the-c-kit-receptor-gene
#19
Tatiana Piqueres-Zubiaurre, Zuriñe Martínez de Lagrán, Ricardo González-Pérez, Amaia Urtaran-Ibarzabal, Guiomar Perez de Nanclares
BACKGROUND: Familial progressive hyperpigmentation (FPH) is an autosomal dominant disorder characterized by the appearance of hyperpigmented patches on the skin from early infancy that increase in size and number with age. METHODS: We report the clinical and molecular studies of an 11-year-old boy who had areas of hyperpigmentation since birth that had spread across his body as irregular hyperpigmented macules and papules, and include relevant history in family members...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27973642/laser-treatments-for-postinflammatory-hyperpigmentation-a-systematic-review
#20
Oma Agbai, Iltefat Hamzavi, Jared Jagdeo
Importance: Lasers are gaining interest as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma given the risk for laser-induced or exacerbated PIH. Objective: To assess the clinical evidence for the use of lasers in the treatment of PIH. Evidence Review: A systematic review was performed by searching PubMed databases from January 1, 1990, through May 31, 2016. Included studies involved laser treatment for PIH with the degree of pigmentation as a measure of outcome...
December 14, 2016: JAMA Dermatology
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