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Skin hyperpigmentation

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https://www.readbyqxmd.com/read/28823078/sesquiterpenes-from-fruits-of-torilis-japonica-with-inhibitory-activity-on-melanin-synthesis-in-b16-cells
#1
Da Hye Song, Yang Hee Jo, Jong Hoon Ahn, Seon Beom Kim, Cheong-Yong Yun, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong Lee
Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28805937/new-data-on-hyperpigmentation-disorders
#2
REVIEW
S Schalka
Recently visible light (VL) and vascularization triggered by infrared light (IR) play a role in hyperpigmentation disorders of the skin. The aim of this article is to provide an update on the aetiology of hyperpigmentation disorders and means of prevention against UV, visible (VL) and infrared light (IR). The author conducted a literature review of the most recent data about hyperpigmentation disorders and means of prevention and protection. VL impacts on pigmentation, especially in individuals with phototype III, IV or V and also causes the production of Reactive Oxygen Species (ROS), erythema and DNA damage through ROS production as well as photodermatoses...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28792112/a-pilot-study-of-treatment-of-striae-distensae-with-variable-square-pulse-erbium-yag-laser-resurfacing
#3
Rungsima Wanitphakdeedecha, Walailak Meeprathom, Woraphong Manuskiatti
BACKGROUND: Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. Various laser treatments have been employed to remove the epidermis and cause dermal wound and heating with subsequent dermal collagen remodeling. OBJECTIVE: To determine the efficacy and safety of a variable square pulse Erbium: YAG (VSP Er:YAG) laser for the treatment of striae in skin phototypes III-IV. METHODS: Twenty-one women with SD were treated monthly for 2 months with VSP Er:YAG laser resurfacing using a 7-mm spot size...
August 9, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28790335/involvement-of-transient-receptor-potential-cation-channel-member-a1-activation-in-the-irritation-and-pain-response-elicited-by-skin-lightening-reagent-hydroquinone
#4
Yan Tai, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, Boyi Liu
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Here we demonstrate that HQ is an activator of the peripheral irritant receptor transient receptor potential (TRP) cation channel member A1 (TRPA1)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759110/effects-of-early-combinatorial-treatment-of-autologous-split-thickness-skin-grafts-in-red-duroc-pig-model-using-pulsed-dye-laser-and-fractional-co2-laser
#5
J Kevin Bailey, Britani N Blackstone, Danielle M DeBruler, Jayne Y Kim, Molly E Baumann, Kevin L McFarland, Folasade O Imeokparia, Dorothy M Supp, Heather M Powell
BACKGROUND AND OBJECTIVE: The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studies report positive outcomes following PDL or FX CO2 therapy, a number of studies have reported no benefit or worsening of the scar following treatment. The objective of this study was to directly compare the efficacy of PDL, FX CO2 , and PDL + FX CO2 laser therapy in reducing scarring post burn injury and autografting in a standardized animal model...
July 31, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28752785/localized-pigmentation-disorder-after-subcutaneous-pegylated-interferon-beta-1a-injection
#6
Giancarlo Coghe, Laura Atzori, Jessica Frau, Giuseppe Fenu, Lorena Lorefice, Maria Giovanna Marrosu, Eleonora Cocco
We report the case of a 42-year-old female patient who developed peculiar skin lesions due to subcutaneous polyethylene glycol (PEG) interferon beta-1a. The dermatological examination showed hypochromic macules that had coalesced into a 10-cm-diameter patch. On the abdomen injection sites, there was a greyish diffuse hyperpigmentation arranged irregularly in annular macules. Fungal infection, vitiligo and pityriasis alba were excluded. After 6 months, the lesions had worsened. This is the first case of localized pigmentation disorder reported with interferon beta, and while the clinical findings are not ascribable to vitiligo or interferon-related facial/mucosal hyperpigmentation, they may partially share the underlining mechanisms...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28749546/familial-progressive-hyperpigmentation-a-family-resurvey-and-ultrastructural-skin-investigation
#7
Tingmei Wang, Hongwen Li, Yingying Dong, Man Hu, Qiuyun She, Yunhua Deng
Familial progressive hyperpigmentation (FPH) is an autosomal dominant genodermatosis characterized by hyperpigmented patches that increase in size and number with age. Since its initial description in an African-American family in 1971, only a few cases of FPH have been documented. A three-generation family with FPH in central China has also been reported. Here, we resurveyed that Chinese FPH family for a few unusual features including delayed age of onset and non-involvement of ocular and oral mucosae. Electron microscopic examination of skin from the proband of the family showed that there were more melanosomes in lesional keratinocytes than in perilesional keratinocytes...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28748967/melanocytic-nevi-and-non-neoplastic-hyperpigmentations
#8
C Clemente
This is the first of three chapters that will be progressively published on Pathologica as updating activity of the Italian Study Group of Dermatopathology (GISD), Italian Society of Pathology and Cytology (SIAPeC IAP). The first chapter concerns non-neoplastic hyperpigmented skin lesions and nevi, the second will address the topics of dysplastic nevus, borderline and low malignant potential melanocytic proliferations and the third melanoma in its variants and differential diagnoses with a supplement on the immunohistochemistry and molecular support to diagnostic and prognostic definition of nevi and melanomas...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28746258/treatment-of-facial-acne-scarring-with-fractional-carbon-dioxide-laser-in-asians-a-retrospective-analysis-of-efficacy-and-complications
#9
Harumi Ochi, Lixian Tan, Wee Ping Tan, Chee Leok Goh
BACKGROUND: Fractional carbon dioxide (CO2) laser resurfacing unites the idea of fractional photothermolysis with an ablative 10,600-nm wavelength. This technology permits effective treatment of acne scarring, with shorter recovery and a decreased side effect profile as compared to traditional CO2 laser resurfacing. OBJECTIVE: The aims of this study were to study the efficacy and safety of fractional CO2 laser for acne scars in Asian patients. METHODS: This was a retrospective study of all patients treated with the fractional CO2 laser for facial acne scarring between January 2, 2008, and December 31, 2010, at the National Skin Centre, Singapore...
September 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28745006/nevus-of-ota-oculodermal-melanocytosis-in-a-dog
#10
Pedro Malho, Anita Shea, David Donaldson
A 5-year-old, female, spayed Rhodesian Ridgeback presented with ocular melanocytosis and skin hyperpigmentation involving the distribution of the first and second divisions of the trigeminal nerve on the right side of the face. The dermatomal pattern of the hyperpigmentation was similar to nevus of Ota or oculodermal melanocytosis reported in humans. This condition has been associated with increased risk of developing secondary glaucoma and melanoma transformation in skin, ocular, orbital tissues, and the central nervous system...
July 25, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28733999/retinyl-propionate-and-climbazole-combination-demonstrates-clinical-improvement-to-the-appearance-of-hyperpigmentation-and-deep-wrinkling-with-minimal-irritation
#11
Stacy Hawkins, Jean Adamus, Chung-Yi Chiang, Edwin Covell, Jaime O'Leary, Jian-Ming Lee
OBJECTIVE: To evaluate a combination of retinyl propionate and climbazole (RPC) compared to 0.1% retinol for its efficacy, tolerance and aging appearance. METHOD: Forty-five healthy Caucasian females, ages 40-70, with moderately photodamaged facial skin, were recruited for a 16 week randomized, double-blind, IRB approved facial study. The efficacy of RPC treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split-face product application...
July 22, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28728861/-vitiligo-occurring-on-dermal-melanocytosis-nevus-of-ota-in-a-dark-skinned-patient
#12
K-C Ahogo, I-P Gbery, B Vagamon, O-A Ouattara, K-A Kouassi, H-S Kourouma, Y-I Kouassi
BACKGROUND: Nevus of Ota is a rare disease most frequently found in Asians. It presents clinically as a bluish gray hyperpigmentation of one side of the face. Transformation into melanoma and glaucoma are the main risks. The appearance of vitiligo lesions with poliosis within a nevus of Ota is exceptional. PATIENTS AND METHODS: A 22-year-old female patient with a nevus of Ota consulted for depigmentation of the eyelashes. Physical examination revealed hyperpigmentation in the right orbitofrontal part of her face, achromic macules and eyelash poliosis...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#13
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28712336/clinical-and-histological-studies-of-suborbital-wrinkles-treated-with-fractional-bipolar-radiofrequency
#14
Jun Huang, Wenyou Yu, Zhen Zhang, Xiaodong Chen, Ewelina Biskup
Fractional bipolar radiofrequency (FRF) has been well established for facial rejuvenation, but there is no report showing its efficacy for the treatment of suborbital wrinkles. The aim of this study was to investigate and objectively evaluate the clinical efficacy and side effects of FRF for the treatment of suborbital wrinkles, including observation of histological changes of the suborbital skin along the therapy. 32 female patients with suborbital wrinkles underwent 3 sessions of FRF at 3-week intervals with a follow-up period of 6 months after treatment...
July 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28710566/remarkable-effects-of-imatinib-in-a-family-with-young-onset-gastrointestinal-stromal-tumors-and-cutaneous-hyperpigmentation-associated-with-a-germline-kit-trp557arg-mutation-case-report-and-literature-overview
#15
S Farag, L E van der Kolk, H H van Boven, A C J van Akkooi, G L Beets, J W Wilmink, N Steeghs
Gastrointestinal stromal tumors (GISTs) occur mostly sporadically. GISTs associated with a familial syndrome are very rare and are mostly wild type for KIT and platelet-derived growth factor alpha (PDGFRA). To date 35 kindreds and 8 individuals have been described with GISTs associated with germline KIT mutations. This is the third family described with a germline p.Trp557Arg mutation in exon 11 of the KIT gene. The effect of imatinib in patients harboring a germline KIT mutation has been rarely described. Moreover, in some studies imatinib treatment was withheld considering the lack of evidence for efficacy of this treatment in GIST patients harboring a germline KIT mutation...
July 14, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28695326/anti-melanogenic-effect-of-gomisin-n-from-schisandra-chinensis-turcz-baillon-schisandraceae-in-melanoma-cells
#16
JungNo Lee, Hwa Sun Ryu, Jae-Moon Kim, Tae-Hwa Jung, Sung-Min Park, Yong-Moon Lee
Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz.) Baillon extract yielded five major compounds, β-chamigrenal, α-ylangenol, gomisin N, gomisin A, and schisandrin. The structures were identified by using (1)H-NMR and (13)C-NMR spectroscopy and comparing the spectral data with published data...
July 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28690515/a-case-of-facial-partial-unilateral-lentiginosis-treated-with-low-fluence-1-064-nm-q-switched-neodymium-doped-yttrium-aluminum-garnet-laser
#17
En Hyung Kim
Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Although treatment is not necessary, many patients with facial PUL seek medical help for cosmetic reasons. There is no established standard treatment for PUL. Conventional lasers may cause postinflammatory hyperpigmentation because keratinocytes are injured during the process. Also, scarring, long downtime, and pain are important issues. A 19-year-old patient with facial PUL was successfully treated with low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28689798/ethyl-acetate-extract-from-panax-ginseng-c-a-meyer-and-its-main-constituents-inhibit-%C3%AE-melanocyte-stimulating-hormone-induced-melanogenesis-by-suppressing-oxidative-stress-in-b16-mouse-melanoma-cells
#18
Rui Jiang, Xiao-Hao Xu, Ke Wang, Xin-Zhao Yang, Ying-Fei Bi, Yao Yan, Jian-Zeng Liu, Xue-Nan Chen, Zhen-Zhong Wang, Xiao-Li Guo, Da-Qing Zhao, Li-Wei Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener to inhibit melanin formation in China, Korea and some other Asian countries. However, the constituents and the molecular mechanisms by which they affect melanogenesis are not fully clear. AIM OF THE STUDY: The purpose of this study was to identify the active ingredient in Panax ginseng C...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28670354/psychosocial-impact-of-postinflammatory-hyperpigmentation-in-patients-with-acne-vulgaris
#19
Kavita Darji, Reena Varade, Daniel West, Eric S Armbrecht, Mary A Guo
Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation...
May 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28662511/antimelanogenic-efficacy-of-melasolv-3-4-5-trimethoxycinnamate-thymol-ester-in-melanocytes-and-three-dimensional-human-skin-equivalent
#20
John Hwan Lee, Eun-Soo Lee, Il-Hong Bae, Jeong-Ah Hwang, Se-Hwa Kim, Dae-Yong Kim, Nok-Hyun Park, Ho Sik Rho, Yong Jin Kim, Seong-Geun Oh, Chang Seok Lee
BACKGROUND/AIMS: Excessive melanogenesis often causes unaesthetic hyperpigmentation. In a previous report, our group introduced a newly synthesized depigmentary agent, Melasolv™ (3,4,5-trimethoxycinnamate thymol ester). In this study, we demonstrated the significant whitening efficacy of Melasolv using various melanocytes and human skin equivalents as in vitro experimental systems. METHODS: The depigmentary effect of Melasolv was tested in melan-a cells (immortalized normal murine melanocytes), α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 murine melanoma cells, primary normal human melanocytes (NHMs), and human skin equivalent (MelanoDerm)...
2017: Skin Pharmacology and Physiology
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