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Skin hyperpigmentation

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https://www.readbyqxmd.com/read/29663691/an-evaluation-of-the-antiaging-properties-of-strawberry-hydrolysate-treatment-enriched-with-l-ascorbic-acid-applied-with-microneedle-mesotherapy
#1
Agata Markiewicz, Malwina Zasada, Anna Erkiert-Polguj, Marzena Wieckowska-Szakiel, Elzbieta Budzisz
BACKGROUND: Mature skin is characterized by a loss of elasticity, hyperpigmentation, and dehydration. L-ascorbic acid stimulates the synthesis of collagen type I, inhibits melanogenesis, and helps to maintain correct skin hydration. Combining microneedle mesotherapy with the application of preparations rich in vitamin C results in better therapeutic effects due to the improved absorption of active substances. The study evaluates the effectiveness of the application of strawberry hydrolysate enriched with L-ascorbic acid using microneedle mesotherapy...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29663460/treatment-of-atrophic-acne-scarring-with-fractional-micro-plasma-radio-frequency-in-chinese-patients-a-prospective-study
#2
Ting Lan, Yan Xiao, Li Tang, Michael R Hamblin, Rui Yin
BACKGROUND: Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infections, and prolonged erythema make these treatments unsatisfactory especially for Asians. Fractional micro-plasma radio-frequency is a novel technology that produces minor ablation to the epidermis to promote rapid re-epithelialization, while the radio-frequency evoked thermal effect can stimulate regeneration and remodeling of dermal fibroblasts...
April 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29661122/lymphocytic-mural-folliculitis-resembling-epitheliotropic-lymphoma-in-tigers-panthera-tigris
#3
Mee-Ja M Sula, Linda A Frank, Edward C Ramsay
A striking form of lymphocytic mural folliculitis is described in 6 tigers ( Panthera tigris). Clinically, all tigers exhibited regionally extensive chronic, variably waxing and waning alopecia with minimal scaling and crusting most pronounced over the head, neck, and shoulders. More severely affected tigers exhibited marked hyperpigmentation and lichenification. Pruritus was not a feature. Tigers generally lacked signs of systemic illness and clinical pathology findings were unremarkable. Histologic examination of skin biopsies revealed infiltrative lymphocytic mural folliculitis extending the length of the hair follicle...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29660917/medical-compression-stockings-reduce-hypertension-of-nailfold-capillaries-at-the-toe-of-patients-with-chronic-venous-insufficiency1
#4
Anja Oelert, Manuela Kittel, Martin Hahn, Hermann Haase, Michael Jünger
In five patients who suffered from chronic venous insufficiency clinical stage C4 (n = 3) and C6 (n = 2) the capillary blood pressure was measured twice by means of invasive direct cannulation of nailfold capillaries of the toe. During one measurement course the patients wore below knee medical compression stockings (40 mmHg) during the other they did not have compression therapy. With the patient in supine position, the CP was investigated by the servo-nulling technique under resting conditions and under dynamic conditions: the calf-muscle/ankle joint venous pump was simulated by means of inflating a blood pressure cuff, which surrounded the mid lower leg, to 60 mmHg for 60 s...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29659405/the-safety-and-efficacy-of-treatment-with-a-1-927-nm-diode-laser-with-and-without-topical-hydroquinone-for-facial-hyperpigmentation-and-melasma-in-darker-skin-types
#5
Monique J Vanaman Wilson, Isabela T Jones, Joanna Bolton, Lisa Larsen, Sabrina Guillen Fabi
BACKGROUND: The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery. OBJECTIVE: To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V. METHODS: Forty adults underwent 4 laser treatments at 2-week intervals and were randomized to daily application of 2% HQ cream or moisturizer...
April 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29658945/experience-with-ok-432-in-lymphatic-vascular-malformations-in-a-hospital-from-northern-mexico
#6
Jorge Alberto Cantú Reyes, Erik Antonio Mier Escurra, Joel Cázares Rangel, Julieta Rodríguez De Ita, Jan Lammel Lindemann, Luis Francisco Rendón García, Boris José Chacón López
Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6000 to -16000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK-432 are being studied...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29657669/dual-effect-of-photobiomodulation-on-melasma-downregulation-of-hyperpigmentation-and-enhanced-solar-resistance-a-pilot-study
#7
Daniel Barolet
Overview. Melasma is a resistant, sun-induced facial hyperpigmentation capable of remaining present for decades with ensuing psychological distress. Treatment is difficult and focuses on an array of measures to reduce skin hyperpigmentation resulting from triggered hyperactive melanocytes. The pathogenesis of melanoma is not clearly understood but it has been reported that some growth factors and specific cell-signaling pathways are involved. Objective. The objective of the current study was to evaluate the use of pulsed photobiomodulation to modulate melasma via the regulation of gene expression pertaining to skin pigmentation...
April 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29642467/proton-partial-breast-irradiation-detailed-description-of-acute-clinico-radiologic-effects
#8
Valentina Ovalle, Eric A Strom, Simona Shaitelman, Karen Hoffman, Richard Amos, George Perkins, Welela Tereffe, Benjamin D Smith, Michael Stauder, Wendy Woodward
Introduction: Accelerated partial breast irradiation (APBI) with protons results in a very different acute effect profile than standard whole breast irradiation. We reviewed our initial experience with proton APBI and felt that a detailed description of these effects were needed to permit a common tool to compare experience with this developing technology. Methods: Sixty sequential patients treated with proton APBI on a prospective protocol were evaluated and 43 patients with a minimum six-month follow-up underwent detailed photographic and radiologic analysis...
April 7, 2018: Cancers
https://www.readbyqxmd.com/read/29642438/sesamol-inhibited-melanogenesis-by-regulating-melanin-related-signal-transduction-in-b16f10-cells
#9
Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. However, overproduction of melanin, in addition to altering the appearance of skin, may lead to skin disorders such as melasma, solar lentigo, and postinflammatory hyperpigmentation...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29630166/phytophotodermatitis-induced-by-wild-parsnip
#10
Abigail L Walling, Hobart W Walling
Phytophotodermatitis results when skin is exposed to ultraviolet light after previous contact with a phototoxic compound. Wild parsnip (Pastinia sativa), a member of the Umbelliferae family, is an invasive plant species introduced to North America as a root vegetable. Although cultivated less commonly today, the plant is increasingly found growing wild in prairies and roadsides. The stems and leaves contain furocoumarins, which upon activation by UV light interact with oxygen. Resultant reactive oxygen species induce tissue damage manifesting initially as blistering and later as hyperpigmentation...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29623194/case-report-dermoscopic-features-of-oral-lichen-planus-the-evolution-of-mucoscopy
#11
Sidharth Sonthalia, Sangeeta Varma, Abhijeet Kumar Jha, Deepak Jakhar, Feroze Kaliyadan
Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. However, the dermoscopic features of oral lichen planus with hand-held or videodermoscopy remain to be elucidated...
2018: F1000Research
https://www.readbyqxmd.com/read/29623021/biochemical-aspects-of-mammalian-melanocytes-and-the-emerging-role-of-melanocyte-stem-cells-in-dermatological-therapies
#12
REVIEW
Sharique A Ali, Ishrat Naaz
Skin color in animals is richer than human beings and is determined by different types of pigments. Melanin is the key pigment responsible for the diverse pigmentation found in animal and human skin, hair, and eyes. Melanin pigment is synthesized by melanocytes and is consecutively transferred to adjacent keratinocytes; here, it acts as an internal sunscreen to defend from ultraviolet (UV) damage. Any defect in the process of melanocytes development and/or melanin synthesis results in esthetic problem of abnormal pigmentation...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29621941/anti-melanogenic-effects-of-resorcinol-are-mediated-by-suppression-of-camp-signaling-and-activation-of-p38-mapk-signaling
#13
Mingyeong Kang, See-Hyoung Park, Sae Woong Oh, Seung Eun Lee, Ju Ah Yoo, Youn Hwa Nho, Sukyeon Lee, Byung Seok Han, Jae Youl Cho, Jongsung Lee
In this study, we investigated the inhibitory mechanisms of resorcinol in B16F10 mouse melanoma cells. We found that resorcinol reduced both the melanin content and tyrosinase activity in these cells. In addition, resorcinol suppressed the expression of melanogenic gene microphthalmia-associated transcriptional factor (MITF) and its downstream target genes tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. In addition, we found that resorcinol reduced intracellular cAMP levels and protein kinase A (PKA) activity, and increased phosphorylation of the p38 mitogen-activated protein kinase (MAPK)...
April 5, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29616617/formulation-of-chitosan-patch-incorporating-artocarpus-altilis-heartwood-extract-for-improving-hyperpigmentation
#14
Jutatip Kwankaew, Preeyawass Phimnuan, Sombat Wanauppathamkul, Jarupa Viyoch
Artocarpus altilis heartwood extract contains the bioactive compound artocarpin which exhibits melanogenesis inhibitory activity. However, the extract has poor solubility which affects the skin permeability of the compound. A chitosan hydrogel patch incorporating A. altilis heartwood extract was formulated to enhance the delivery of an amount of artocarpin sufficient for depigmenting the skin. The extract was prepared as an o/w microemulsion before blending with an aqueous solution of chitosan. The hydrogel patch was formulated by blending in a 1:1 ratio by weight of 4% w/w chitosan solution and 0...
July 2017: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29608215/prospective-study-of-removing-solar-lentigines-in-asians-using-a-novel-dual-wavelength-and-dual-pulse-width-picosecond-laser
#15
Kei Negishi, Hirotaka Akita, Yukiko Matsunaga
OBJECTIVES: Quality-switched (QS) lasers are known to be an effective treatment for removing solar lentigines, however, high incidence of post-inflammatory hyperpigmentation (PIH) is a concern in darker skin types. The objective of this study was to evaluate the efficacy and safety of a dual-wavelength and dual-pulse width picosecond Nd:YAG laser for removing solar lentigines in Asians. METHODS: This was a prospective, IRB-approved study. Twenty cases with solar lentigines on the face were enrolled for treatment and evaluated at 1- and 3-month after the final treatment...
April 2, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29604530/double-cross-finger-flaps-from-the-middle-to-the-index-or-ring-finger-a-case-series-of-4-patients-with-an-emphasis-on-donor-finger-morbidity
#16
Omar M Al-Qattan, Abdulaziz A Almobarak, Mohammad M Al-Qattan
INTRODUCTION: The use of two cross finger flaps from one digit has not been previously reported and the technique raises concerns regarding donor finger morbidity. In this paper, the authors report on a case series of double cross fingers flaps harvested from the middle finger to reconstruct large defects in the adjacent index or ring finger; with an emphasis on documenting morbidity in the donor middle finger. METHODS: A total of four cases of double cross finger flaps were retrospectively reviewed...
March 26, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29601620/multi-center-double-blind-vehicle-controlled-clinical-trial-of-an-alpha-and-beta-defensin-containing-anti-aging-skin-care-regimen-with-clinical-histopathologic-immunohistochemical-photographic-and-ultrasound-evaluation
#17
Amy Taub, Vivian Bucay, Gregory Keller, Jay Williams, Darius Mehregan
BACKGROUND/OBJECTIVES: Anti-aging strategies utilizing stem cells are in the forefront. Alpha and beta defensins are natural immune peptides that have been shown to activate an LGR6-positive stem cell locus in the hair follicle, identified as the source of most new epidermal cells during acute wound healing. We investigated the ability of biomimetic alpha and beta defensin molecules, supplemented with supportive cosmetic ingredients, formulated into three skin care products, at improving the structure and function of aging skin...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29600693/photodynamic-therapy-for-esthetic-cosmetic-indications
#18
Wolfgang G Philipp-Dormston
Photodynamic therapy (PDT) is a well-established, non-invasive treatment for a variety of dermatologic disorders, including actinic keratosis. Furthermore, PDT results in marked improvements in the signs of skin aging, although currently there are no standardized guidelines for PDT in skin rejuvenation. Two types of PDT are available: conventional-PDT (c-PDT) and the newly introduced daylight-PDT (DL-PDT). Both require a topical photosensitizer, a light source and oxygen, and both are comparable regarding safety and efficacy for treatment of photo-induced skin aging...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29581746/utility-of-dermoscopy-for-evaluating-the-therapeutic-efficacy-of-tacrolimus-ointment-plus-308-nm-excimer-laser-combination-therapy-in-localized-vitiligo-patients
#19
Lu-Mei Wang, Wan-Jiao Lu, Jing-Tao Yuan, Bi-Bing Zeng, Dan Li, Feng Zhang, Jun-Jie Li
The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled and received combination therapy for 12 weeks. The condition of the skin lesions was monitored by dermoscopy and visual observation. At the initial visit, skin lesions were observed in 61 progressive and 19 stable patients...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29573885/use-of-bilaminar-grafts-as-life-saving-interventions-for-severe-burns-a-single-center-experience
#20
Johnny Ionut Efanov, Bianief Tchiloemba, Antoine Duong, Annie Bélisle, Ali Izadpanah, Edouard Coeugniet, Michel Alain Danino
BACKGROUND: Skin coverage remains a significant hurdle in large-sized burns. Recent advances have allowed to grow Bilaminar Cultured Skin Autografts (BCSGs) from patients' own donor sites. The aim of this study was to report long-term outcomes in patients with large-sized burns having received BCSGs. METHODS: Nine patients received BCSGs from January 2010 to May 2015. Except one patient who died during hospitalization, all patients were contacted. Four agreed to partake in the study...
March 21, 2018: Burns: Journal of the International Society for Burn Injuries
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