keyword
MENU ▼
Read by QxMD icon Read
search

Actinic lesions

keyword
https://www.readbyqxmd.com/read/29351725/daylight-mediated-photodynamic-therapy-with-methyl-aminolevulinate-in-actinic-keratosis-treatment
#1
Shantel D J Demay, Kunal Sharma, Sheetal Sapra, Rahul Sapra, Priya Sapra
BACKGROUND: Research has shown daylight-mediated photodynamic therapy (PDT) for the treatment of actinic keratosis (AK) to be effective, tolerable, and convenient, with excellent patient satisfaction and cosmesis. Although success has been demonstrated in areas with similar latitudes to Switzerland and Scandinavia, this treatment has not been studied in a Canadian population. OBJECTIVES: The purpose of this study is to investigate the effectiveness, safety, and patient satisfaction of daylight-mediated methyl 5-aminolevulinate (MAL)-PDT to make recommendations for its use in Canadian practice...
January 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29351118/multiple-eyelid-cysts-apocrine-and-eccrine-hidrocystomas-trichilemmal-cyst-and-hybrid-cyst-in-a-patient-with-a-prolactinoma
#2
Lina Ma, Frederick A Jakobiec, Natalie Wolkow, Thaddeus P Dryja, Gary E Borodic
A 53-year-old man presented with smooth-domed, variegated cysts (polycystic disease) of all 4 eyelids, worse on the left side. Some of the cysts were clear, while others were creamy-white colored. In addition, multiple, very fine vesicopapules were noted along the eyelid margins. Histopathologic examination revealed a trichilemmal cyst, several pure apocrine hidrocystomas displaying multiple chambers, a hybrid cyst, and many small eccrine cysts of the deep dermis. The apocrine lesions, including the small ones at the eyelid margins, predominated...
January 18, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29350263/histological-findings-after-argon-plasma-coagulation-an-ex-vivo-study-revealing-a-possible-role-in-superficial-ablative-treatment-of-the-skin
#3
L Schmitz, S Hessam, L Scholl, S Reitenbach, M H Segert, T Gambichler, E Stockfleth, F G Bechara
Argon plasma coagulation (APC) is an electrosurgical technique which can be used to ablate skin lesions with limited invasion depth into dermal tissue. Hence, APC might be well suited for the removal of epithelial tumours. However, there are no data on the effects of APC on human skin tissue. Thus, the aim of this study was to determine the extent of epidermal and dermal damage after APC of human skin. We performed APC ex-vivo on 91 freshly resected human skin samples, which were obtained after reconstructive surgical closures in actinically damaged areas...
January 19, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29344474/corneal-myofibroma-keloid-in-a-young-patient-with-neurofibromatosis-type-2
#4
Lisa Zimmermann, Thomas Reinhard, Clemens Lange, Steffen Heegaard, Claudia Auw-Haedrich
We present a 27-year-old male patient with neurofibromatosis type 2 (NF2), facial palsy, and lagophthalmos following acoustic neuroma removal and an impressing vascularized corneal tumor, which was excised. Histology showed a fibrous tumor with small vessels, and immunohistochemistry was positive for vimentin and negative for smooth muscle actin, S100, and GFAP. We assume a corneal myofibroma (keloid), which in this case rather represents a reactive lesion. This entity has not been described before in NF2 or in facial palsy-associated lagophthalmos in general...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344318/noninvasive-long-term-monitoring-of-actinic-keratosis-and-field-cancerization-following-treatment-with-ingenol-mebutate-gel-0-015
#5
Orit Markowitz, Katie Wang, Amanda Levine, Michelle Schwartz, Sumeet Minhas, Eleanor Feldman, Daniel M Siegel
OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. SETTING: An outpatient clinic. PARTICIPANTS: Fifteen of the original 28 study patients enrolled in and who completed the extension phase...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-phosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#6
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4, and was first approved in Japan for the treatment of adult T cell leukaemia/lymphoma (ATLL), followed by cutaneous T cell lymphoma and peripheral T cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T cell neoplasms after treatment with Mog. METHODS: We treated 7 cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29340950/dermatologic-lesions-submitted-to-an-oral-and-maxillofacial-pathology-biopsy-service-an-analysis-of-2487-cases
#7
Rekha Reddy, Liya Davidova, Indraneel Bhattacharyya, Donald M Cohen, Mohammed N Islam, Sarah G Fitzpatrick
Skin lesions are often submitted to oral and maxillofacial pathology practices. The purpose of this study is to evaluate the frequency, distribution, variability, and composition of dermatologic lesions within a large oral and maxillofacial pathology biopsy service. An IRB-approved retrospective search of skin lesions diagnosed at University of Florida oral and maxillofacial pathology biopsy service between 1994 and 2015 was performed. 2487 cases were included in the study. Gender was reported in 2466 cases, of which 59% were male and 41% female...
January 16, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29339694/aortic-%C3%AE-smooth-muscle-actin-expressions-in-aortic-disorders-and-coronary-artery-disease-an-immunohistochemical-study
#8
Shi Min Yuan, Ning Wu
OBJECTIVE: The is to report immunohistochemical observations of aortic α-smooth muscle actin (SMA) expressions in patients with aortic aneurysm, acute aortic dissection, and coronary artery disease and to discuss phenotypic switching of smooth muscle cells (SMCs) of these lesions. METHODS: Forty-nine consecutive patients scheduled for surgical treatment for acute type A aortic dissection (20 patients), aortic aneurysm (9 patients), and coronary artery disease (20 patients) were included...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29331035/noninvasive-optical-spectroscopy-for-identification-of-non-melanoma-skin-cancer-pilot-study
#9
David J Carpenter, Mirabelle B Sajisevi, Nikita Chapurin, Clifford Scott Brown, Tracy Cheng, Gregory M Palmer, Daniel S Stevenson, Caroline L Rao, Russell P Hall, Charles R Woodard
OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. For each skin lesion, provider pre-biopsy probability of malignancy was compared to histolopathologic diagnosis...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29324470/fibroma-like-pecoma-a-tuberous-sclerosis-complex-related-lesion
#10
Ana B Larque, Richard L Kradin, Ivan Chebib, G Petur Nielsen, Martin K Selig, Elizabeth A Thiele, Anat Stemmer-Rachamimov, Miriam A Bredella, Pawel Kurzawa, Vikram Deshpande
Perivascular epithelioid cell tumor (PEComa), mesenchymal tumors morphologically characterized by epithelioid cells, coexpress melanocytic and muscle markers. Herein, we describe a heretofore-undescribed tuberous sclerosis complex (TSC)-related neoplasm, morphologically resembling a soft tissue fibroma-like lesion, but showing an immunophenotype resembling PEComa. We identified 3 soft tissue fibroma-like lesions in individuals with TSC. We also evaluated 6 TSC-related periungual fibroma as well as a range of non-TSC fibroma-like lesions (n=19)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29322431/daylight-photodynamic-therapy-versus-5-fluorouracil-for-the-treatment-of-actinic-keratosis-a-case-series
#11
Gaston Nestor Galimberti
INTRODUCTION: The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. METHODS: Five male subjects (mean age 70 years) with grade I-III AK on the face/scalp were enrolled...
January 10, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29316785/intracellular-peptide-self-assembly-a-biomimetic-approach-for-in-situ-nano-drug-preparation
#12
Wei Du, Xiaomu Hu, Weichen Wei, Gaolin Liang
Most of the nano-drugs are pre-prepared by encapsulating or loading the drugs with nano-carriers (e.g., dendrimers, liposomes, micelles, and polymeric nanoparticles). However, besides the low bioavailability and fast excretion of the nano-drugs in vivo, nano-carriers often exhibit in vitro and in vivo cytotoxicity, oxidative stress, and inflammation. Self-assembly is a ubiquitous process in biology where it plays important roles and underlies the formation of a wide variety of complex biological structures...
January 9, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29314300/low-grade-fibromyxoid-sarcoma-arising-within-the-median-nerve
#13
Amy A Swanson, Caterina Giannini, Andrew L Folpe, Daniel L Van Dyke, Kimberly K Amrami, William A Michalak, Rachael A Vaubel
We report a case of low-grade fibromyxoid sarcoma arising within the median nerve. A 31-year-old woman presented with symptoms of carpal tunnel syndrome and an enlarging mass in her right palm over 1 year. MRI demonstrated a mass associated with the right median nerve with solid and cystic components. At surgery, the mass was located within the epineurium, could be bluntly dissected from the nerve fascicles, and was suspected to be a schwannoma. A 3.4 cm, tan-pink, glistening, smooth, homogenous mass was submitted to pathology...
January 3, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29313389/multi-target-stool-dna-test-in-the-surveillance-of-inflammatory-bowel-disease-a-cross-sectional-cohort-study
#14
Pasquale Klepp, John B Kisiel, Milada Cvancarova Småstuen, Arne Røseth, Solveig N Andersen, Morten H Vatn, David A Ahlquist, Bjørn A Moum, Stephan Brackmann
BACKGROUND AND AIM: Colonoscopic surveillance is recommended in patients with longstanding inflammatory bowel disease (IBD) as they are at increased risk of colorectal cancer (CRC). Non-invasive surveillance may improve compliance and access. Multi-target stool DNA (MT-sDNA) has been validated for screening of sporadic CRC but has not been assessed in IBD. Our aim was to assess the performance of a MT-sDNA test in a real-life surveillance setting of patients with longstanding IBD. MATERIAL AND METHODS: A total of 192 IBD patients enrolled from two prospective cohorts submitted an EDTA buffered stool sample and underwent chromo- or white light colonoscopy...
January 9, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29311041/5-fluorouracil-chemowraps-for-the-treatment-of-multiple-actinic-keratoses
#15
Lucie Peuvrel, Mélanie Saint-Jean, Gaëlle Quereux, Anabelle Brocard, Marie Le Moigne, Cécile Frénard, Amir Khammari, Brigitte Dreno
Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29298652/astragalin-attenuates-uvb-radiation-induced-actinic-keratosis-formation
#16
Jian Zhang, Na Li, Kun Zhang, Ping Pan, Hui Zhang, Ning Li, Qiong Tian, Li Zhang, Wenli Liu, Tianyuan Gao, Xin Mu, Dengchao Feng, Wei Guo, Xiaona Ma
Actinic keratosis (AK), is the most common precancerous skin lesion induced by the excessive ultraviolet B (UVB) and is a significant threat to the public health. UVB exposure causes oxidative DNA damage and is considered to be a significant contributor to AK and subsequent development of skin cancer. Besides, activation of p38 MAPK also plays a significant role in the development of AK. In our clinical findings revealed that p38 MAPK, phospho-MSK1, and γ-H2AX were significantly highly expressed in human AK tissue than the normal healthy skin tissue...
December 29, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29290325/-adenomyoepithelioma-of-the-breast-report-of-four-cases-and-literature-review
#17
Cristina Díaz Del Arco, Lourdes Estrada Muñoz, Alejandro Pascual Martín, Adela Pelayo Alarcón, David de Pablo Velasco, Luis Ortega Medina
Adenomyoepitheliomas of the breast are infrequent tumors with a variable histological appearance, and they can mimic several epithelial, myoepithelial and biphasic lesions of the breast. We have reviewed four cases of adenomyoepithelioma of the breast diagnosed between 2005 and 2015 in our institution (Hospital Clínico San Carlos). Mean age was 57years. All lesions were solid irregular masses located in the upper quadrants (3 of them in the right breast and one in the left), with an average size of 13mm. Microscopically 2 of them were tubular and the remaining 2 were lobulated subtypes...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29285126/analysis-of-human-papilloma-virus-type-52-integration-status-in-exfoliated-cervical-cells
#18
Ke Zhang, Zhanjun Liu, Ji Li, Juan Li, Jianghong Yan, Yunchuan Su, Shuying Li, Jintao Li
To explore the significance of human papilloma virus type 52 (HPV52) infection and its integration in cells within cervical lesions, the expression levels of HPV52 were detected using polymerase chain reaction (PCR). The copy numbers of HPV52 E2, HPV52 E6 and the reference gene β-actin were determined by quantitative PCR to analyze the association between HPV52 integration and cervical lesions. HPV52 integration was analyzed by the amplification of papillomavirus oncogene transcripts. A total of 13 samples from 468 cases were positive for HPV52...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282394/treatment-of-multiple-actinic-keratosis-and-field-of-cancerization-with-topical-piroxicam-0-8-and-sunscreen-50-in-organ-transplant-recipients-a-series-of-10-cases
#19
Virginia Garofalo, Alessandra Ventura, Sara Mazzilli, Laura Diluvio, Luca Bianchi, Luca Toti, Giuseppe Tisone, Massimo Milani, Elena Campione
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282193/plantar-fibromatosis-in-a-mentally-challenged-man-treated-with-intralesional-corticosteroids
#20
Ayse Serap Karadag, Emin Ozlu, Ayse Bahar Ceyran, Mehmet Simsek, Tugba Kevser Uzuncakmak, Ilkin Zindancı, Necmettin Akdeniz
A 21-year-old mentally challenged man presented with a fixed plaque lesion on the right foot, which had been present for 10 years. Dermatologic examination revealed an erythematous, painful, firm, fixed plaque-nodular lesion on the plantar aspect of the right foot (Figure 1A). Nothing of distinction was noted from his family history or his laboratory tests. An incisional biopsy revealed parallel, regular bundles composed of uniform, plump spindle cells. Thin collagen fibers were seen in contact with and located between the spindle cells...
2017: Skinmed
keyword
keyword
48295
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"