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Transdermal laser

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https://www.readbyqxmd.com/read/27917779/low-pressure-sequential-compression-of-lower-limbs-enhances-forearm-skin-blood-flow
#1
Guy Amah, Sebastian Voicu, Philippe Bonnin, Nathalie Kubis
PURPOSE: We investigated whether forearm skin blood flow could be improved when a multilayer pulsatile inflatable suit was applied at a low pressure to the lower limbs and abdomen. We hypothesized that a non-invasive purely mechanical stimulation of the lower limbs could induce remote forearm blood flow modifications. METHODS: The pulsatile suit induced a sequential compartmentalized low compression (65 mmHg), which was synchronized with each diastole of the cardiac cycle with each phase evolving centripetally (lower limbs to abdomen)...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27914995/transdermal-skin-patch-based-on-reduced-graphene-oxide-a-new-approach-for-photothermal-triggered-permeation-of-ondansetron-across-porcine-skin
#2
Florina Teodorescu, Gurvan Quéniat, Catherine Foulon, Marie Lecoeur, Alexandre Barras, Samia Boulahneche, Mohmaed Salah Medjram, Thomas Hubert, Amar Abderrahmani, Rabah Boukherroub, Sabine Szunerits
The development of a skin-mounted patch capable of controlled transcutaneous delivery of therapeutics through thermal activation provides a unique solution for the controlled release of active principles over long-term periods. Here, we report on a flexible transdermal patch for photothermal triggered release of ondansetron (ODS), a commonly used drug for the treatment of chemotherapy-induced nausea and vomiting and used as model compound here. To achieve this, a dispersion of ODS-loaded reduced graphene oxide (rGO-ODS) nanosheets were deposited onto Kapton to produce a flexible polyimide-based patch...
November 30, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27877042/effects-of-carbopol-%C3%A2-934-proportion-on-nanoemulsion-gel-for-topical-and-transdermal-drug-delivery-a-skin-permeation-study
#3
Yin Zheng, Wu-Qing Ouyang, Yun-Peng Wei, Shahid Faraz Syed, Chao-Shuang Hao, Bo-Zhen Wang, Yan-Hong Shang
Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol(®) 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27854332/fractional-co%C3%A2-laser-pretreatment-facilitates-transdermal-delivery-of-two-vitamin-c-derivatives
#4
Chien-Yu Hsiao, Hsin-Ching Sung, Sindy Hu, Yau-Li Huang, Chun-Hsun Huang
BACKGROUND: Topical vitamin C derivatives have been used to treat melasma and used as a skin whitener. The aim of this study was to compare skin histology and permeation of l-ascorbic acid 2-phosphate sesquimagnesium salt (MAP-1) and magnesium l-ascorbic acid-2-phosphate (MAP-2) after fractional CO₂ laser pretreatment. METHODS: The effect of fractional laser treatment on porcine skin was examined by scanning electron microscopy and confocal laser scanning electron microscopy...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27833475/noninvasive-transdermal-vaccination-using-hyaluronan-nanocarriers-and-laser-adjuvant
#5
Ki Su Kim, Hyemin Kim, Yunji Park, Won Ho Kong, Seung Woo Lee, Sheldon J J Kwok, Sei Kwang Hahn, Seok Hyun Yun
Vaccines are commonly administered by injection using needles. Although transdermal microneedles are less-invasive promising alternatives, needle-free topical vaccination without involving physical damage to the natural skin barrier is still sought after as it can further reduce needle-induced anxiety and simply administration. However, this long-standing goal has been elusive since the intact skin is impermeable to most macromolecules. Here, we show an efficient, non-invasive transdermal vaccination in mice by employing two key innovations: first, the use of hyaluronan (HA) as vaccine carriers and, second, non-ablative laser adjuvants...
April 19, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27822034/promotion-of-the-transdermal-delivery-of-protein-drugs-by-n-trimethyl-chitosan-nanoparticles-combined-with-polypropylene-electret
#6
Ye Tu, Xinxia Wang, Ying Lu, He Zhang, Yuan Yu, Yan Chen, Junjie Liu, Zhiguo Sun, Lili Cui, Jing Gao, Yanqiang Zhong
We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27818244/the-effect-of-pulse-duration-power-and-energy-of-fractional-er-yag-laser-for-transdermal-delivery-of-differently-sized-fitc-dextrans
#7
Barbara Zorec, Dejan Škrabelj, Marko Marinček, Damijan Miklavčič, Nataša Pavšelj
We studied fractional Er:YAG laser to enhance transdermal drug delivery of compounds possessing different molecular weights: FITC-dextrans (or FD) with average molecular weights of 4, 10 and 20kDa. Vertical glass Franz diffusion cells were used to study molecular transport through dermatomed porcine skin and histological analysis of laser-treated skin was performed after treatment with different laser pulse protocols. We were comparing different pulse durations at constant or varying pulse energies. We found that the energy of the delivered pulses mostly dictates the size/depth of laser-created microchannels, while the duration of the pulses dictates the extent of thermally altered tissue...
November 3, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27778355/skin-pre-ablation-and-laser-assisted-microjet-injection-for-deep-tissue-penetration
#8
Hun-Jae Jang, Seonggu Yeo, Jack J Yoh
BACKGROUND AND AIMS: For conventional needless injection, there still remain many unresolved issues such as the potential for cross-contamination, poor reliability of targeted delivery dose, and significantly painstaking procedures. As an alternative, the use of microjets generated with Er:YAG laser for delivering small doses with controlled penetration depths has been reported. In this study, a new system with two stages is evaluated for effective transdermal drug delivery. First, the skin is pre-ablated to eliminate the hard outer layer and second, laser-driven microjet penetrates the relatively weaker and freshly exposed epidermis...
October 25, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27771484/in-vivo-skin-penetration-of-macromolecules-in-irritant-contact-dermatitis
#9
Mona M A Abdel-Mottaleb, Alf Lamprecht
Recently, a selective preferential accumulation of polymeric nanoparticles (in the size range around 100nm) has been observed in the follicular system of dermatitis skin. The present investigation aimed at clearly investigating the effect of irritant contact dermatitis on the barrier permeability for colloidal systems below this size range, namely quantum dots and hydrophilic macromolecules. Irritant dermatitis was induced in mice and the penetrability of quantum dots (5nm) and hydrophilic dextran molecules has been tracked in both healthy and inflamed skin using confocal laser scanning microscopy...
October 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27624669/non-ablative-fractional-laser-to-facilitate-transdermal-delivery
#10
Sindhu S Ganti, Ajay K Banga
The advances in laser technology have led to its rapidly expanding applications in dermatology. This study aims at the novel use of a non-ablative fractional laser to enhance transdermal permeation of diclofenac sodium and sumatriptan succinate. The effects of the laser on skin were characterized visually with dye binding, scanning electron microscopy, pore permeability index, and histology. In vitro transdermal permeation of drugs through laser treated and untreated human dermatomed skin was analyzed over 24 h and quantified by HPLC...
November 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27622085/clinical-assessment-of-the-safety-and-effectiveness-of-nonablative-fractional-laser-combined-with-transdermal-delivery-of-botulinum-toxin-a-in-treating-periocular-wrinkles
#11
Xing Fan, Yue Yin, Shiping Wang, Tong Li, Ping Xue, Qing Yang, Qiaoxin Ma
The upper and lower eyelids are traditionally contraindicated for subcutaneous botulinum toxin A (BTX) injection because of possible complications. We assessed the clinical safety and effectiveness of nonablative fractional laser (NAFL) combined with transdermal delivery of BTX in the treatment of periocular wrinkles. Thirty patients who had periocular wrinkles were treated with 1,565-nm NAFL in combination in the left periocular area and normal saline in the corresponding area of the right eye. VISIA skin detector was used to photograph and compare the changes induced by treatment...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27599202/a-novel-effective-method-for-the-assessment-of-microvascular-function-in-male-patients-with-coronary-artery-disease-a-pilot-study-using-laser-speckle-contrast-imaging
#12
J P Borges, G O Lopes, V Verri, M P Coelho, P M C Nascimento, D A Kopiler, E Tibirica
Evaluation of microvascular endothelial function is essential for investigating the pathophysiology and treatment of cardiovascular and metabolic diseases. Although laser speckle contrast imaging technology is well accepted as a noninvasive methodology for assessing microvascular endothelial function, it has never been used to compare male patients with coronary artery disease with male age-matched healthy controls. Thus, the aim of this study was to determine whether laser speckle contrast imaging could be used to detect differences in the systemic microvascular functions of patients with established cardiovascular disease (n=61) and healthy age-matched subjects (n=24)...
September 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27544847/-epigallocatechin-gallate-egcg-nanoethosomes-as-a-transdermal-delivery-system-for-docetaxel-to-treat-implanted-human-melanoma-cell-tumors-in-mice
#13
Bingwu Liao, Hao Ying, Chenhuan Yu, Zhaoyang Fan, Weihua Zhang, John Shi, Huazhong Ying, Nagaiya Ravichandran, Yongquan Xu, Junfeng Yin, Yongwen Jiang, Qizhen Du
(-)-Epigallocatechin-3-O-gallate (EGCG), a versatile natural product in fresh tea leaves and green tea, has been investigated as a preventative treatment for cancers and cardiovascular disease. The objective of this study was to develop EGCG-nanoethosomes for transdermal delivery and to evaluate them for treating subcutaneously implanted human melanoma cell tumors. EGCG-nanoethosomes, composed of 0.2% EGCG, 2% soybean phosphatidylcholine, 30% ethanol, 1% Tween-80 and 0.1% sugar esters, were prepared and characterized using laser transmission electron microscopy...
October 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27540293/improved-skin-permeation-of-methotrexate-via-nanosized-ultradeformable-liposomes
#14
Alam Zeb, Omer Salman Qureshi, Hyung-Seo Kim, Ji-Hye Cha, Hoo-Seong Kim, Jin-Ki Kim
The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27526697/ethosomes-as-vesicles-for-effective-transdermal-delivery-from-bench-to-clinical-implementation
#15
Nida Akhtar, Anurag Verma, Kamla Pathak
BACKGROUND: Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. A number of efforts have been put forward to find ways to get therapeutic actives overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have been investigated for its potential where high proportion of ethanol enables them to ameliorate transdermal delivery of several drugs in comparison to other carriers...
August 13, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27492948/influence-of-sonophoresis-on-transdermal-drug-delivery-of-hydrophilic-compound-loaded-lipid-nanocarriers
#16
Worranan Rangsimawong, Praneet Opanasopit, Theerasak Rojanarata, Suwannee Panomsuk, Tanasait Ngawhirunpat
The effect of sonophoresis on the transdermal drug delivery of sodium fluorescein (NaFI)-loaded lipid nanocarriers such as liposomes (LI), niosomes (NI) and solid lipid nanoparticles (SLN) was investigated by confocal laser scanning microscopy (CLSM), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results showed that SN decreased the skin penetration of NaFI-loaded SLN (6.32-fold) and NI (1.79-fold), while it increased the penetration of NaFI-loaded LI (5.36-fold)...
August 30, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27491379/preparation-and-evaluation-of-novel-hydrogel-based-on-polysaccharide-isolated-from-bletilla-striata
#17
Xiuming Cui, Xingying Zhang, Ye Yang, Chengxiao Wang, Chaoyu Zhang, Gang Peng
Natural polysaccharides are highly valued and extensively applied in drug delivery system for their desirable physical properties and unique bioactivities. In this work, natural polysaccharides from Bletilla striata (BSP) were successfully extracted and incorporated with Carbopol 940 to prepare hydrogels. Rheological behavior, skin permeation properties and bioactivities of the BSP hydrogels were evaluated. The rheological test showed the better viscoelasticity and physical strength of BSP gels from Carbopol gel...
August 4, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27453793/impact-of-cosmetic-lotions-on-nanoparticle-penetration-through-ex-vivo-c57bl-6-hairless-mouse-and-human-skin-a-comparison-study
#18
Samreen Jatana, Linda M Callahan, Alice P Pentland, Lisa A DeLouise
Understanding the interactions of nanoparticles (NPs) with skin is important from a consumer and occupational health and safety perspective, as well as for the design of effective NP-based transdermal therapeutics. Despite intense efforts to elucidate the conditions that permit NP penetration, there remains a lack of translatable results from animal models to human skin. The objectives of this study are to investigate the impact of common skin lotions on NP penetration and to quantify penetration differences of quantum dot (QD) NPs between freshly excised human and mouse skin...
March 2016: Cosmetics
https://www.readbyqxmd.com/read/27419471/clinical-effect-of-ablative-fractional-laser-assisted-topical-anesthesia-on-human-skin-a-randomized-pilot-study
#19
Tian Tian, Yaojia Luo, Tianling Jiang, Yuxi Dong, Aijiao Yu, Hongduo Chen, Xinghua Gao, Yuanhong Li
BACKGROUND AND OBJECTIVES: Most topical medications need a long time to penetrate into the skin owing to the stratum corneum (SC) barrier. The fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser has the ability to disrupt the SC and assist in the delivery of topical drugs to penetrate into the skin. This study was intended to determine whether pretreatment with a painless fractional Er:YAG laser could assist transdermal delivery of topical anesthesia. MATERIALS AND METHODS: In 22 healthy female subjects, three 4 × 3 cm regions on the right forearm were randomized to: fractional laser plus topical lidocaine cream (Group LaserAnes), sham irradiation plus topical anesthesia (Group Anes), and sham irradiation plus sham anesthesia (Group Con)...
August 5, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27389611/transdermal-thiol-acrylate-polyethylene-glycol-hydrogel-synthesis-using-near-infrared-light
#20
Solchan Chung, Hwangjae Lee, Hyung-Seok Kim, Min-Gon Kim, Luke P Lee, Jae Young Lee
Light-induced polymerization has been widely applied for hydrogel synthesis, which conventionally involves the use of ultraviolet or visible light to activate a photoinitiator for polymerization. However, with these light sources, transdermal gelation is not efficient and feasible due to their substantial interactions with biological systems, and thus a high power is required. In this study, we used biocompatible and tissue-penetrating near infrared (NIR) light to remotely trigger a thiol-acrylate reaction for efficient in vivo gelation with good controllability...
August 7, 2016: Nanoscale
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