keyword
https://read.qxmd.com/read/38532901/a-6-year-old-with-childhood-absence-epilepsy-and-motor-hyperactivity
#1
JOURNAL ARTICLE
Stéphane Auvin
A case study of a child with childhood absence epilepsy and hyperactivity introduces the discussion around the psychiatric diagnosis, differential considerations, and pharmacologic treatment options for ADHD/hyperactivity in children with epilepsy. Most of the time, ADHD in children with epilepsy is an inattentive form. The assessment emphasizes the need to differentiate ADHD symptoms from other psychiatric comorbidities. This is also crucial to evaluate when symptoms emerged, their impact on daily life, and if it could be a potential medication side effect...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38506810/attention-deficit-hyperactivity-disorder-medications-and-work-disability-and-mental-health-outcomes
#2
JOURNAL ARTICLE
Heidi Taipale, Jakob Bergström, Katalin Gèmes, Antti Tanskanen, Lisa Ekselius, Ellenor Mittendorfer-Rutz, Magnus Helgesson
IMPORTANCE: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have comorbid psychiatric conditions. Relatively little is known about how specific ADHD medications are associated with overall treatment outcomes among these patients. OBJECTIVE: To investigate the association of the use of specific ADHD medications with hospitalization outcomes and work disability among adolescents and adults with ADHD. DESIGN, SETTING, AND PARTICIPANTS: This nationwide register-based cohort study identified individuals (aged 16-65 years) with ADHD from Swedish nationwide registers of inpatient health care, specialized outpatient health care, sickness absence, and disability pension during the years 2006 to 2021...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38504095/individualized-atomoxetine-response-and-tolerability-in-children-with-adhd-receiving-different-dosage-regimens-the-need-for-cyp2d6-genotyping-and-therapeutic-drug-monitoring-to-dance-together
#3
JOURNAL ARTICLE
Hong-Li Guo, Dan-Dan Wu, Di Fu, Yue Li, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Wei-Rong Fang, Jing Xu, Ya-Hui Hu, Qian-Qi Liu, Feng Chen
Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to investigate the link between the efficacy and tolerability of atomoxetine in children with ADHD and plasma atomoxetine concentrations based on their CYP2D6 genotypes; (2) to offer TDM reference range recommendations for atomoxetine based on the CYP2D6 genotypes of children receiving different dosage regimens...
March 19, 2024: Translational Psychiatry
https://read.qxmd.com/read/38488615/erratum-the-combination-of-aroxybutynin-and-atomoxetine-in-the-treatment-of-obstructive-sleep-apnea-mariposa-a-randomized-controlled-trial
#4
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38477521/recent-updates-on-treatment-patterns-in-patients-with-treated-attention-deficit-hyperactivity-disorders-from-a-nationwide-real-world-database-in-south-korea
#5
JOURNAL ARTICLE
Yoon Cho, Ah-Young Kim, Sukhyang Lee, Hankil Lee
The prevalence of attention-deficit/hyperactivity disorder (ADHD) is steadily increasing across Korea. We analyzed ADHD patients with ADHD medications (Rx) characteristics and treatment patterns compared to patients without Rx and identified the differences between pediatric-/adult- and active-/transient-patients with Rx. Using a nationwide claims dataset from 2020 to 2021, we conducted a prevalence-based cross-sectional study and analyzed the recent patients' characteristics and patterns among ADHD patients...
March 11, 2024: International Clinical Psychopharmacology
https://read.qxmd.com/read/38472614/pictures-at-an-exhibition-a-commentary-on-benn-robinson-2024
#6
JOURNAL ARTICLE
Barry Setlow, Matthew R Burns
No abstract text is available yet for this article.
March 12, 2024: Cognitive, Affective & Behavioral Neuroscience
https://read.qxmd.com/read/38465816/-attention-deficit-hyperactivity-disorder-in-adults
#7
JOURNAL ARTICLE
L S Chutko, S Yu Surushkina, E A Yakovenko, D V Cherednichenko
The article presents a review of scientific publications devoted to the study of the characteristics of the clinical picture and the dynamics of the main symptoms in adult patients with attention deficit hyperactivity disorder (ADHD). The authors present current data on the prevalence of this disease, leading clinical manifestations and the most common comorbid pathology. Research data on the impact of ADHD in adulthood on educational and professional activities are presented, and the economic and criminological aspects of ADHD are considered...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38436168/genotoxic-and-genoprotective-effects-of-some-antipsychotic-drugs-methylphenidate-and-atomoxetine-on-human-lymphocytes-and-hepg2-cells
#8
JOURNAL ARTICLE
S K Sezer, S Yuksel, I Ucuz
OBJECTIVE: Aripiprazole, risperidone, atomoxetine, and methylphenidate are drugs commonly prescribed for many psychiatric conditions and can be used alone or in combination in children and adolescents. This study aimed to investigate comparatively the possible genotoxic effects or genoprotective potentials of these drugs on human lymphocytes and HepG2 cells. MATERIALS AND METHODS: Cytotoxicity analysis was performed with the cell viability test on human lymphocytes and HepG2 cells, and half-maximal inhibitory concentration (IC50) values of the drugs were determined, and three different doses (¼ IC50, ½ IC50, and IC50) were applied for genetic analysis...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38432409/attention-deficit-hyperactivity-disorder-in-pregnancy-and-the-postpartum-period
#9
REVIEW
Olivia Scoten, Katarina Tabi, Vanessa Paquette, Prescilla Carrion, Deirdre Ryan, Nevena V Radonjic, Elizabeth A Whitham, Catriona Hippman
Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder that frequently persists into adulthood, with 3% of adult women having a diagnosis of ADHD. Many women are diagnosed and treated during their reproductive years, resulting in management implications across pregnancy and postpartum. We know from clinical practice that ADHD symptoms frequently become challenging to manage during the perinatal period, requiring additional support and attention. There is often uncertainty among healthcare providers regarding the management of ADHD in the perinatal period, particularly the safety of pharmacotherapy for the developing fetus...
March 1, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38416571/effect-of-biofeedback-intervention-on-neurological-characteristics-of-children-with-attention-deficit-hyperactivity-disorder
#10
JOURNAL ARTICLE
Cai Zhang, Xiaoxuan Zhou, Nanfei Hu, Lin Xu
Objective: To evaluate the effects of biofeedback intervention on the neurological characteristics of children with attention deficit hyperactivity disorder (ADHD). Methods: 150 children aged 6 to 12 years with ADHD were divided into two groups according to the treatment method. The atomoxetine group received atomoxetine drug treatment, and the combined treatment group received EEG biofeedback therapy. Continuous performance Test (CPT), SNAP-IV and WFIRS-P were used to assess attention and behavior, and functional magnetic resonance imaging (fMRI) was used to observe changes in brain activity...
February 28, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38397275/atomoxetine-treatment-of-attention-deficit-hyperactivity-disorder-symptoms-in-3-6-year-old-children-with-autism-spectrum-disorder-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Hamza A Alsayouf, Osama Alsarhan, Wael Khreisat, Azhar Daoud
Atomoxetine is indicated for the management of attention deficit/hyperactivity disorder (ADHD) in children and adolescents aged 6 to 18 years. Few studies have assessed the safety and tolerability of atomoxetine in younger patients. This retrospective cohort study included 133 children aged 3-6 years who were diagnosed with ADHD comorbid with autism spectrum disorder (ASD). The primary endpoint was the evaluation of the safety profile of atomoxetine. In total, 50 patients (37.6%) experienced adverse events (AEs), which led to treatment discontinuation in 23 patients (17...
January 26, 2024: Children
https://read.qxmd.com/read/38357032/comorbidity-of-attention-deficit-hyperactivity-disorder-in-a-patient-with-epilepsy-staring-down-the-challenge-of-inattention-versus-nonconvulsive-seizures
#12
REVIEW
Derryl J Miller, Hannah Komanapalli, David W Dunn
Epilepsy is a heterogeneous disorder of recurrent seizures which often is comorbid with anxiety, depression, attention deficit hyperactivity disorder (ADHD), intellectual disability (ID), and other psychiatric manifestations. Treating both epilepsy and behavioral symptoms from psychiatric disorders can result in polypharmacy with interactions of medications leading to both worsened efficacy of antiseizure medications due to psychotropic effects and worsening of psychiatric symptoms due to antiseizure medication side effects...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38341903/pharmacological-treatment-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#13
REVIEW
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
OBJECTIVE: Summarize the evidence on drug therapies for obstructive sleep apnea. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. PubMed, Embase, Scopus, Web of Science, SciELO, LILACS, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched on February 17th, 2023. A search strategy retrieved randomized clinical trials comparing the Apnea-Hypopnea Index (AHI) in pharmacotherapies...
2024: Clinics
https://read.qxmd.com/read/38294169/continuation-of-treatment-in-children-with-adhd-a-multicenter-turkish-sample-study
#14
JOURNAL ARTICLE
Saliha Baykal, Cansu Çobanoğlu Osmanlı, Abdullah Bozkurt, Bedia Sultan Önal, Berkan Şahin, Müge Karaçizmeli, Ayşegül Öz Gazi, Koray Karabekiroğlu
OBJECTIVES: The aim of this study was to investigate the variables that may affect treatment continuation in children aged 6 to 12 years who were newly diagnosed with ADHD. METHODS: A total of 132 children diagnosed with ADHD and their parents participated in the study. Sociodemographic and clinical risk factors affecting continuation of treatment were examined using logistic regression analysis. RESULTS: Multiple model examination revealed that greater age increased the risk of treatment discontinuation 1...
January 31, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38286618/combination-pharmacological-therapy-targeting-multiple-mechanisms-of-sleep-apnoea-a-randomised-controlled-cross-over-trial
#15
JOURNAL ARTICLE
Scott A Sands, Jinny Collet, Laura K Gell, Nicole Calianese, Lauren B Hess, Daniel Vena, Ali Azarbarzin, Suzanne M Bertisch, Shane Landry, Luke Thomson, Simon A Joosten, Garun S Hamilton, Bradley A Edwards
RATIONALE: Acetazolamide and atomoxetine-plus-oxybutynin ('AtoOxy') can improve obstructive sleep apnoea (OSA) by stabilising ventilatory control and improving dilator muscle responsiveness respectively. Given the different pathophysiological mechanisms targeted by each intervention, we tested whether AtoOxy-plus-acetazolamide would be more efficacious than AtoOxy alone. METHODS: In a multicentre randomised crossover trial, 19 patients with moderate-to-severe OSA received AtoOxy (80/5 mg), acetazolamide (500 mg), combined AtoOxy-plus-acetazolamide or placebo at bedtime for three nights (half doses on first night) with a 4-day washout between conditions...
January 29, 2024: Thorax
https://read.qxmd.com/read/38258290/spectrophotometric-quantification-of-atomoxetine-hydrochloride-based-on-nucleophilic-substitution-reaction-with-1-2-naphthoquinone-4-sulfonic-acid-sodium-salt-nqs
#16
JOURNAL ARTICLE
Swathi Naraparaju, Padmavathi Yamjala, Soujanya Chaganti, Durga Panikumar Anumolu
OBJECTIVES: A simple, sensitive, selective, and cost-effective colorimetric method has been established for the quantitative estimation of atomoxetine hydrochloride in bulk and formulation.A simple, sensitive, selective and cost effective colorimetric method has been entrenched for the quantitative estimation of Atomoxetine hydrochloride in bulk and formulation. MATERIALS AND METHODS: It was established based on the visible reaction between atomoxetine hydrochloride and 1,2-naphthoquinone-4-sulfonic acid sodium salt in a basic medium (potassium hydroxide)...
January 19, 2024: Turkish journal of pharmaceutical sciences
https://read.qxmd.com/read/38253774/development-of-a-novel-rodent-rapid-serial-visual-presentation-task-reveals-dissociable-effects-of-stimulant-versus-nonstimulant-treatments-on-attentional-processes
#17
JOURNAL ARTICLE
Abigail Benn, Emma S J Robinson
The rapid serial visual presentation (RSVP) task and continuous performance tasks (CPT) are used to assess attentional impairments in patients with psychiatric and neurological conditions. This study developed a novel touchscreen task for rats based on the structure of a human RSVP task and used pharmacological manipulations to investigate their effects on different performance measures. Normal animals were trained to respond to a target image and withhold responding to distractor images presented within a continuous sequence...
January 22, 2024: Cognitive, Affective & Behavioral Neuroscience
https://read.qxmd.com/read/38229445/comparing-pharmacotherapies-for-adhd-in-adults-evidence-from-outcome-focused-analysis-of-food-and-drug-administration-drug-label-registration-trials
#18
JOURNAL ARTICLE
Craig B H Surman, Daniel M Walsh, Joseph B Bond
OBJECTIVE: We appraised whether FDA registration trials for ADHD pharmacotherapy in adults provides comparable information to inform treatment expectations. METHOD: Comparison of ADHD outcome measure patterns in ADHD pharmacotherapy FDA drug label source studies. RESULTS: Among stimulants, from fixed-dose titration data, amphetamine agents had numerically higher placebo-corrected symptom improvement and symptom effect sizes than methylphenidate agents...
January 16, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38219711/evidence-of-hypothalamic-pituitary-adrenal-and-gonadal-dysfunction-in-cocaine-addicted-men
#19
Karen D Ersche, Jan Stochl, Annette B Brühl, Mark Gurnell
INTRODUCTION: Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction, and impaired quality of life. However, cocaine's endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises...
January 12, 2024: European Addiction Research
https://read.qxmd.com/read/38204741/effectiveness-and-tolerability-of-combination-pharmacotherapy-with-stimulant-and-non-stimulant-in-children-with-attention-deficit-hyperactivity-disorder
#20
JOURNAL ARTICLE
Hyung Nam Park, Na Yeong Kong, Hee-Cheol Kim, Yang Tae Kim, Sung-Won Jung, Hojun Lee
OBJECTIVES: This study aimed to investigate the effectiveness and safety of combining psychostimulants and nonstimulants for patients under treatment for attention deficit hyperactivity disorder (ADHD). METHODS: The study included 96 patients aged 6-12 years who were diagnosed with ADHD, among whom 34 received combination pharmacotherapy, 32 received methylphenidate monotherapy, and 30 received atomoxetine monotherapy. Statistical analysis was conducted to compare treatment and adverse effects among groups and to analyze changes before and after combination pharmacotherapy...
January 1, 2024: Soa--chʻŏngsonyŏn chŏngsin ŭihak, Journal of child & adolescent psychiatry
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