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Atomoxetine

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https://www.readbyqxmd.com/read/27911044/utilization-of-stimulants-and-atomoxetine-for-attention-deficit-hyperactivity-disorder-among-5-4-million-children-using-population-based-longitudinal-data
#1
Kari Furu, Øystein Karlstad, Helga Zoega, Jaana E Martikainen, Shahram Bahmanyar, Helle Kieler, Anton Pottegård
Use of stimulants to treat Attention-deficit/hyperactivity disorder (ADHD) has increased over the past two decades and varies substantially between countries. The objective of this multinational population-based study was to examine utilization of ADHD drugs (stimulants and atomoxetine) including co-medication with other psychothropic drugs in the entire child population in the five Nordic countries. We included longitudinal data on dispensed ADHD drugs from five Nordic prescription registers during 2008-2012; which in 2012 comprised 48,296 individuals among 5...
December 2, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27866408/prescribing-patterns-for-attention-deficit-hyperactivity-disorder-medications-among-children-and-adolescents-in-korea-2007-2011
#2
Inmyung Song, Ju-Young Shin
OBJECTIVES: This study analyzed the prevalence of attention deficit hyperactivity disorder (ADHD) medication use among children and adolescents in Korea between January 1, 2007 and December 31, 2011. METHODS: Using the Korea National Health Insurance claims database, we identified patients between one and 17 years of age who had at least one medical claim for the diagnosis of ADHD (International Classification of Diseases, 10th revision: F90.0). The annual prevalence of ADHD diagnoses was calculated, using national census data from Statistics Korea on the population aged between one and 17 years as the denominator...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27864240/new-horizons-in-orthostatic-hypotension
#3
REVIEW
James Frith, Steve W Parry
BACKGROUND: orthostatic hypotension (OH) is a common disabling condition associated with increased morbidity and mortality. Much of the evidence available is derived from younger populations with chronic neurological disease leading to uncertainty for the diagnosis and management of older people. OBJECTIVE: to provide an overview of recent and emerging evidence for the diagnosis, management and prognosis of OH in older persons. METHODS: a narrative review of recent studies, emerging therapies and relevant regulatory updates...
November 17, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27859666/effectiveness-of-atomoxetine-and-methylphenidate-for-problematic-online-gaming-in-adolescents-with-attention-deficit-hyperactivity-disorder
#4
Jeong Ha Park, Young Sik Lee, Ji Hyun Sohn, Doug Hyun Han
OBJECTIVE: There is a high prevalence of problematic online gaming in adolescents with attention deficit hyperactivity disorder (ADHD). In the current study, we compared the effectiveness of atomoxetine (ATM) and methylphenidate (MPH) on problematic online gaming in adolescents with ADHD. METHODS: We recruited 86 adolescents diagnosed with ADHD together with Internet gaming disorder. These participants were divided into two treatment groups: 44 participants were treated with MPH for 12 weeks, and 42 participants were treated with ATM for 12 weeks...
November 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27858723/safety-and-improvement-of-movement-function-after-stroke-with-atomoxetine-a%C3%A2-pilot-randomized-trial
#5
Andrea Ward, Cheryl Carrico, Elizabeth Powell, Philip M Westgate, Laurie Nichols, Anne Fleischer, Lumy Sawaki
BACKGROUND: Intensive, task-oriented motor training has been associated with neuroplastic reorganization and improved upper extremity movement function after stroke. However, to optimize such training for people with moderate-to-severe movement impairment, pharmacological modulation of neuroplasticity may be needed as an adjuvant intervention. OBJECTIVE: Evaluate safety, as well as improvement in movement function, associated with motor training paired with a drug to upregulate neuroplasticity after stroke...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27857045/long-term-pharmacotherapy-by-methylfenidate-or-atomoxetine-dat-1-10-10-adhd-children-in-correlation-with-results-of-the-imaging-methods
#6
(no author information available yet)
OBJECTIVES: ADHD is one of the most significant diagnostic units in child and adolescent psychiatry. The occurrence in children is 5-6% and 50-80% continued to adult age. The presence of individual genes (polymorphism) on particular symptoms and processes in ADHD are not known. It is estimated that ADHD symptoms are up to 80% to genetic. The higher density of resultant DAT 1 protein was observed in ADHD patients in comparison with controls. The question was if DAT 1 10/10 predicted bad prognoses in long term therapy...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27845858/atomoxetine-related-change-in-sluggish-cognitive-tempo-is-partially-independent-of-change-in-attention-deficit-hyperactivity-disorder-inattentive-symptoms
#7
Keith McBurnett, David Clemow, David Williams, Miguel Villodas, Linda Wietecha, Russell Barkley
OBJECTIVES: To evaluate effects of atomoxetine versus placebo on sluggish cognitive tempo (SCT) and determine factors affecting improvement of SCT in children with attention-deficit/hyperactivity disorder (ADHD) with dyslexia (ADHD+D) or dyslexia only. METHODS: This is a post hoc analysis of a 16-week placebo-controlled, double-blind randomized phase of a previously reported atomoxetine study in children aged 10-16 years with ADHD+D, Dyslexia-only, or ADHD-only (no placebo arm)...
November 15, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27828696/current-and-investigational-medication-delivery-systems-for-treating-attention-deficit-hyperactivity-disorder
#8
Rakesh Jain, Alain Katic
OBJECTIVE: To review currently available formulations and emphasize unmet needs in the pharmacologic management of attention-deficit/hyperactivity disorder (ADHD). DATA SOURCES: Publications and clinical trials were identified through PubMed and ClinicalTrials.gov, respectively. A Web-based search identified prescribing information for approved agents for treating ADHD, along with relevant guidelines and diagnostic criteria. STUDY SELECTION: The following search terms were used: (1) ADHD or attention-deficit/hyperactivity disorder or ADD or attention deficit hyperactivity disorder and/or (2) amphetamine or methylphenidate or atomoxetine or guanfacine or clonidine...
August 18, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27817164/comparative-treatment-patterns-healthcare-resource-utilization-and-costs-of-atomoxetine-and-long-acting-methylphenidate-among-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-in-germany
#9
Peter Greven, Vanja Sikirica, Yaozhu J Chen, Tammy G Curtice, Charles Makin
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) imposes a substantial burden on patients and their families. OBJECTIVE: A retrospective, propensity score-matched cohort study compared treatment patterns, healthcare resource utilization (HRU) and costs among children/adolescents with ADHD aged 6-17 years at treatment initiation (index) in Germany who received atomoxetine (ATX) or long-acting methylphenidate (LA-MPH) monotherapy. METHODS: Patients received at least one prescription for their index medication (ATX/LA-MPH) during 2006-2010; the first prescription marked the index date...
November 5, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27817163/psychotropic-medication-use-among-insured-children-with-autism-spectrum-disorder
#10
Jeanne M Madden, Matthew D Lakoma, Frances L Lynch, Donna Rusinak, Ashli A Owen-Smith, Karen J Coleman, Virginia P Quinn, Vincent M Yau, Yinge X Qian, Lisa A Croen
This study examined psychotropic medication use among 7901 children aged 1-17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5 %) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2 %), antipsychotics (20.5 %), and antidepressants (17.8 %). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7...
November 5, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27816979/evaluation-of-the-potential-pharmacokinetic-interaction-between-atomoxetine-and-fluvoxamine-in-healthy-volunteers
#11
Ioana Todor, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ana-Maria Gheldiu, Corina Briciu
BACKGROUND/AIMS: Attention deficit hyperactivity disorder (ADHD) is frequently associated with other psychiatric pathologies. Therefore, the present study investigated a possible pharmacokinetic interaction between atomoxetine (ATX), a treatment option for ADHD, and an antidepressant, namely, fluvoxamine (FVX). METHODS: Designed as an open-label, non-randomized clinical trial, the study included 2 periods. In period 1 (reference), each subject received ATX 25 mg (single-dose), whereas in period 2 (test), all subjects were given a combination of ATX 25 mg + FVX 100 mg, following a 6-day pretreatment regimen with the enzymatic inhibitor...
November 5, 2016: Pharmacology
https://www.readbyqxmd.com/read/27810613/use-of-atomoxetine-and-suicidal-ideation-in-children-and-adolescents-results-of-an-observational-cohort-study-within-general-practice-in-england
#12
M Davies, A Coughtrie, D Layton, S A S Shakir
AIM: To investigate the association between atomoxetine, a drug used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and suicidal ideation, within a cohort of 2-18-year-old patients in England. METHODS: The study was conducted using the observational cohort technique of Modified prescription event monitoring (M-PEM). Patients prescribed atomoxetine were identified from dispensed prescriptions issued by primary care physicians. A customised postal GP questionnaire was used to capture outcome data for suicidal ideation...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27790483/effect-of-poly-unsaturated-fatty-acids-administration-on-children-with-attention-deficit-hyperactivity-disorder-a-randomized-controlled-trial
#13
Puneet Anand, Ankur Sachdeva
INTRODUCTION: Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder of childhood. Studies have indicated nutritional deficiencies, particularly Poly Unsaturated Fatty Acids (PUFA) deficiency in these children and have suggested supplementation with PUFA for clinical improvement. AIM: The present study aimed at evaluating the effect of PUFA administration in Indian children with ADHD. SETTINGS AND DESIGN: The study was conducted in the paediatrics and psychiatry departments of a tertiary care hospital...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27788566/prescribing-patterns-for-attention-deficit-hyperactivity-disorder-adhd-medications-among-children-and-adolescents-in-korea-2007-2011
#14
Inmyung Song, Ju Young Shin
Objectives: This study analyzed the prevalence of attention deficit hyperactivity disorder (ADHD) medication users among children and adolescents in Korea between January 1, 2007 and December 31, 2011. Methods: Using the Korea National Health Insurance claims database, we identified the patients aged between 1 and 17 years who had at least one medical claim for the diagnosis of ADHD (ICD-10: F90.0). The annual prevalence of ADHD diagnosis was calculated, using national census data from the Statistics Korea on the population aged between 1 and 17 years as the denominator...
October 26, 2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27755221/dihydroxyphenylglycol-as-a-biomarker-of-norepinephrine-transporter-inhibition-by-atomoxetine-human-model-to-assess-central-and-peripheral-effects-of-dosing
#15
Peter R Bieck, Mark Leibowitz, D Richard Lachno, Edouard Ledent, Robert Padich, Stan Jhee
To assess the primary metabolite of norepinephrine, 3,4-dihydroxyphenylglycol (DHPG), as a sensitive biomarker for norepinephrine transporter (NET) function and the relationship of DHPG measured peripherally and centrally, NET was antagonized with 80 mg/d atomoxetine for 18 days. Twelve healthy subjects were treated with atomoxetine in an open-label, multiple-dose exploratory study. Plasma atomoxetine reached steady state by day 6, and the pharmacokinetic results demonstrated availability of atomoxetine to the central nervous system...
October 15, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27748724/atomoxetine-successfully-addresses-double-sphincteric-incontinence-in-a-child-with-attention-deficit-hyperactivity-disorder
#16
Ahmed Naguy
No abstract text is available yet for this article.
September 29, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27744551/differential-roles-for-cortical-versus-sub-cortical-noradrenaline-and-modulation-of-impulsivity-in-the-rat
#17
Abigail Benn, Emma S J Robinson
RATIONALE: Atomoxetine is a noradrenaline re-uptake inhibitor licensed for the treatment of adult and childhood attention deficit hyperactivity disorder. Although atomoxetine has established efficacy, the mechanisms which mediate its effects are not well understood. OBJECTIVES: In this study, we investigated the role of cortical versus sub-cortical noradrenaline by using focal dopamine beta hydroxylase-saporin-induced lesions, to the prefrontal cortex (n = 16) or nucleus accumbens shell (n = 18)...
October 15, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27738872/an-evaluation-on-the-efficacy-and-safety-of-treatments-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-comparison-of-multiple-treatments
#18
Ying Li, Jie Gao, Shu He, Yan Zhang, Qiwei Wang
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders. We carried out this comparison of multiple treatments based on sufficient data in attempt to evaluate the efficacy and safety of ADHD medication for children and adolescents. PubMed, Embase and the Cochrane Database were used to search for relevant articles. Changes in the ADHD Rating Scale (ADHD-RS) scores and the Conners' Parent Rating Scale-Revised (CPRS) scores were used as outcomes for efficacy. Withdrawals due to all-cause, adverse effects and lack of efficacy were defined as primary outcomes evaluating the safety of such medications...
October 13, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27721971/efficacy-of-atomoxetine-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-patients-with-common-comorbidities-in-children-adolescents-and-adults-a-review
#19
Shari L Hutchison, Jaswinder K Ghuman, Harinder S Ghuman, Irina Karpov, James M Schuster
Attention-deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed mental health disorders and is associated with higher incidence of comorbid oppositional or conduct, mood, anxiety, pervasive developmental, and substance-use disorders. Comorbid mental health conditions may alter the presence of symptoms and treatment of ADHD. Atomoxetine (ATX), a nonstimulant medication for the treatment of ADHD, may be prescribed for individuals with ADHD and comorbid conditions despite some risk for certain undesirable side effects and lower effectiveness for the treatment of ADHD than stimulants...
October 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27673638/drug-drug-interaction-of-paroxetine-and-atomoxetine-in-different-cyp2d6-genotypes
#20
Y H Kim, J W Bae, C H Jeong, K S Chun, I S Kim, C G Jang, S Y Lee
No abstract text is available yet for this article.
October 6, 2016: Clinical Therapeutics
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