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Saphenous vein

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https://www.readbyqxmd.com/read/28932824/factor-viia-interaction-with-epcr-modulates-the-hemostatic-effect-of-rfviia-in-hemophilia-therapy-mode-of-its-action
#1
Shiva Keshava, Jagan Sundaram, Anuradha Rajulapati, Charles Esmon, Usha Pendurthi, L Vijaya Mohan Rao
Recent studies established that clotting factor VIIa (FVIIa) binds endothelial cell protein C receptor (EPCR). It has been speculated that FVIIa interaction with EPCR might augment the hemostatic effect of rFVIIa in therapeutic conditions. The present study is carried out to investigate the mechanism by which FVIIa interaction with EPCR contributes to the hemostatic effect of rFVIIa in hemophilia therapy. Active-site inhibited FVIIa, which is capable of binding to EPCR but has no ability to activate factor X, reduced the concentration of rFVIIa required to correct the bleeding following the saphenous vein injury in mouse hemophilia model systems...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/28932398/mid-calf-level-as-a-puncture-site-is-not-safe-enough-for-thermal-ablation-of-the-small-saphenous-vein
#2
Soner Sanioglu, Halit Yerebakan, Ali Ozgen, Huseyin O Ozdemir, Nurcan K Sancar, Mustafa B Farsak
BACKGROUND: Endovenous thermal ablation of the small saphenous vein carries a risk for sural nerve injury. Ablation above mid-calf level is recommended to avoid it. However, this strategy could not eradicate this complication. We present our results of consecutive 30 small saphenous vein thermal ablations which are performed after ultrasonographic identification of the sural nerve. METHODS: We studied 26 consecutive subjects with a total of 30 limbs. Ablation was performed proximal to the risk point by a 1470-nm diode laser...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28931249/v3-vertebral-artery-to-anterior-inferior-cerebellar-artery-bypass-with-saphenous-vein-graft-for-vertebrobasilar-ischemia-3-dimensional-operative-video
#3
Arnau Benet, Xuequan Feng, Michael T Lawton
No abstract text is available yet for this article.
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28927755/protein-kinase-ck2-inhibition-suppresses-neointima-formation-via-a-proline-rich-homeodomain-dependent-mechanism
#4
K S Wadey, B A Brown, G B Sala-Newby, P-S Jayaraman, K Gaston, S J George
Neointimal hyperplasia is a product of VSMC replication and consequent accumulation within the blood vessel wall. In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH) could suppress VSMC proliferation. Both silencing and pharmacological inhibition of CK2 with K66 antagonised replication of isolated VSMCs. SiRNA-induced knockdown as well as ectopic overexpression of proline-rich homeodomain indicated that PRH disrupts cell cycle progression...
September 16, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28927554/catheter-foam-sclerotherapy-of-the-great-saphenous-vein-with-perisaphenous-tumescence-infiltration-and-saphenous-irrigation
#5
Attilio Cavezzi, Giovanni Mosti, Fausto Campana, Lorenzo Tessari, Luca Bastiani, Simone U Urso
OBJECTIVES: This was a prospective observational study to assess the short- to mid-term efficacy and safety of catheter foam sclerotherapy (CFS) of the great saphenous vein (GSV), including peri-saphenous tumescence infiltration (PST) and intra-saphenous saline irrigation (ISI), in combination with phlebectomy of the varicose tributaries. METHODS: Eighty-eight limbs in 82 patients (19 male, 63 female, mean age 55.7 years) affected by varices related to GSV incompetence were submitted to CFS of the refluxing GSV segment after PST and ISI, combined with phlebectomy of the varicose tributaries...
September 15, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28912938/comparison-of-endovenous-laser-and-radiofrequency-ablation-in-treating-varices-in-the-same-patient
#6
Orhan Bozoglan, Bulent Mese, Erdinc Eroglu, Hasan Cetin Ekerbiçer, Alptekin Yasim
Introduction: To compare endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) in different legs in the same individual in patients with venous insufficiency. Methods: Sixty patients with bilateral saphenous vein insufficiency were included. EVLA or RFA was applied to one of the patient's legs and RFA or EVLA to the other leg. Results: EVLA and RFA complications were hyperemia at 20.7% and 31.0%, ecchymosis at 31.0% and 51.7% and edema at 27.6% and 65.5%, respectively. The rate of recanalization was 6...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28905682/management-of-post-traumatic-phlegmasia-cerulea-dolens-via-right-to-left-femoral-vein-to-femoral-vein-bypass-palma-procedure
#7
Anahita Dua, Jennifer Heller, Cheong Lee
Phlegmasia cerulea dolens (PCD) is a rare condition resulting from venous occlusion that impairs arterial flow. We report a rare case of post-traumatic PCD after ligation of the iliac vein with successful treatment by right-to-left femoral vein to femoral vein bypass using left great saphenous vein (Palma procedure). The clinical presentation, diagnostic process, and approach to management along with a literature review on the operative management of PCD are presented in this case report.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28905300/p2x7r-antagonism-after-subfailure-overstretch-injury-of-blood-vessels-reverses-vasomotor-dysfunction-and-prevents-apoptosis
#8
Weifeng Luo, Daniel Feldman, Reid McCallister, Colleen Brophy, Joyce Cheung-Flynn
Human saphenous vein (HSV) is harvested and prepared prior to implantation as an arterial bypass graft. Injury and the response to injury from surgical harvest and preparation trigger cascades of molecular events and contribute to graft remodeling and intimal hyperplasia. Apoptosis is an early response after implantation that contributes the development of neointimal lesions. Here, we showed that surgical harvest and preparation of HSV leads to vasomotor dysfunction, increased apoptosis and downregulation of the phosphorylation of the anti-apoptotic protein, Niban...
September 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28894060/-redo-off-pump-coronary-artery-bypass-for-postoperative-vein-graft-stenosis-of-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-report-of-a-case
#9
Taro Minamida, Takashi Sugiki, Masamichi Itou, Yasuhiro Kamikubo, Makoto Takahira
Bland-White-Garland (BWG) syndrome (anomalous origin of the left coronary artery from the pulmonary artery) is a rare disease which may result in myocardial infarction, congestive heart failure or sometimes death during the early infantile period. We present a 57-year-old female with BWG syndrome. At the age of 20, she was diagnosed with BWG syndrome and underwent coronary artery bypass grafting of a saphenous vein to the proximal portion of the anterior descending branch of the left coronary artery and ligation of the anomalous artery...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28893152/a-new-percutaneous-technique-n-butyl-cyanoacrylate-adhesive-for-the-treatment-of-giant-saphenous-vein-insufficiency
#10
Mehmet Senel Bademci, Kaptanıderya Tayfur, Gökhan Ocakoglu, Serkan Yazman, Muhammet Akyüz, Haydar Yasa
Background We have made a retrospective evaluation of the results of the cyanoacrylate ablation technique which has recently started to be used in the treatment of giant saphenous vein insufficiency today and in which tumescent anesthesia is not required. Methods Giant saphenous vein was treated in 50 patients between September 2015 and September 2016 by using endovenous cyanoacrylate ablation. In the procedure, tumescent anesthesia and varsity socks were not used. Control duplex ultrasound evaluation was performed in the post-procedural 1st, 6th and 12th months...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28892412/expert-review-on-the-venaseal%C3%A2-system-for-endovenous-cyano-acrylate-adhesive-ablation-of-incompetent-saphenous-trunks-in-patients-with-varicose-veins
#11
Yee Lai Lam, Marianne De Maeseneer, James Lawson, Gert Jan de Borst, Doeke Boersma
The treatment of incompetent truncal veins has been innovated by the introduction of minimally invasive non-thermal non-tumescent (NTNT) techniques. One of these consists of the use of cyanoacrylate glue to occlude the vein lumen by means of the VenaSeal device. Areas covered: This expert-review aims to evaluate NTNT ablation of incompetent saphenous trunks using the VenaSeal device. Expert commentary: Cyanoacrylate adhesive embolization of incompetent truncal veins using the VenaSeal device is a safe and efficacious innovative technique...
September 11, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28890062/national-utilization-and-outcomes-of-redo-lower-extremity-bypass-vs-endovascular-intervention-after-previous-failed-bypass-redo-lower-extremity-bypass-superior-to-endovascular-intervention
#12
J Hunter Mehaffey, Alexander Shannon, Robert B Hawkins, Anna Fashandi, Margret C Tracci, Irving L Kron, Gilbert R Upchurch, William P Robinson
BACKGROUND: Redo Lower extremity bypass (LEB) and infrainguinal endovascular intervention (IEI) are options to treat critical limb ischemia after a failed prior lower extremity bypass but the utilization and outcomes of each are poorly described. The purpose of this study was to compare 30-day Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) after LEB and IEI in patients with a failed prior ipsilateral LEB and determine risk factors for each composite outcome...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28884387/genome-wide-dna-methylation-patterns-in-coronary-heart-disease
#13
X Wang, A-H Liu, Z-W Jia, K Pu, K-Y Chen, H Guo
BACKGROUND: To better understand the molecular mechanisms of atherosclerosis, we conducted a comparative analysis of DNA methylation patterns in right coronary arteries in the area of advanced atherosclerotic plaques (CAP), great saphenous vein (GSV), and internal mammary artery (IMA) of patients affected by coronary heart disease. METHODS: DNA methylation data (accession number E‑GEOD-62867) were divided into three paired groups: CAP vs. IMA, CAP vs. GSV, and IMA vs...
September 7, 2017: Herz
https://www.readbyqxmd.com/read/28878880/greater-saphenous-vein-anomaly-and-aneurysm-with-subsequent-pulmonary-embolism
#14
Truong Ma, Craig Kornbau
Venous aneurysms often present as painful masses. They can present either in the deep or superficial venous system. Deep venous system aneurysms have a greater risk of thromboembolism. Though rare, there have been case reports of superficial aneurysms and thrombus causing significant morbidity such as pulmonary embolism. We present a case of an anomalous greater saphenous vein connection with an aneurysm and thrombus resulting in a pulmonary embolism. This is the only reported case of an anomalous greater saphenous vein connection with aneurysm and thrombus, which eventually led to a pulmonary embolism...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28877099/risk-of-pulmonary-embolism-in-patients-with-isolated-great-saphenous-vein-thrombus
#15
Akshya Gupta, Vijay Pandya, Timothy Baran, Vikram S Dogra
Risks associated with isolated great saphenous vein (GSV) thrombosis remain controversial. The purpose of this study is to identify the risk of pulmonary embolism (PE) in patients with isolated GSV thrombosis, particularly those with thrombus within 3 cm of the sapheno-femoral junction. A retrospective chart review of color flow Doppler lower extremity venous ultrasound examinations from an academic hospital from 2011 to 2016 was conducted. Seventy-eight patients were identified as having acute thrombus in their GSV and were then further stratified based on the presence or absence of concomitant deep venous thrombosis (DVT)...
September 4, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28876423/thrombosed-aneurysm-of-saphenous-vein-coronary-artery-bypass-grafting
#16
Rodolfo Mendes Queiroz, Rogério Nastri, Marcus Antônio Ferez, Mauro José Brandão da Costa, Claudio Benedini Laguna, Marcus Vinicius Nascimento Valentin
We describe the case of a male patient, aged 76 years, referred for cardiac investigation due to retrosternal chest pain and dyspnea. He had a history of acute myocardial infarction and angioplasties in the last 30 years, including a saphenous vein coronary artery bypass grafting (SVCABG). Echocardiogram showed hypoechoic oval formation near the right ventricle, suggesting a pericardial cyst. Computed angiotomography revealed a predominantly fusiform and thrombosed aneurysmal dilation of the SVCABG to the right coronary artery...
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28866037/very-late-restenosis-of-a-bvs-implanted-in%C3%A2-a-degenerated-saphenous-vein-graft
#17
Juan Gabriel Córdoba-Soriano, Antonio Gutiérrez-Díez, Arsenio Gallardo López, Jesús Jiménez-Mazuecos
No abstract text is available yet for this article.
August 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28865843/activation-and-inflammation-of-the-venous-endothelium-in-vein-graft-disease
#18
REVIEW
Alexander O Ward, Massimo Caputo, Gianni D Angelini, Sarah J George, Mustafa Zakkar
The long saphenous vein is the most commonly used conduit in coronary artery bypass graft (CABG) surgery when bypassing multiple diseased arteries; however, its use is complicated by the development of vascular inflammation, intimal hyperplasia and accelerated atherosclerosis leading to compromised graft efficacy. Despite refinement of surgical techniques to improve graft patency, late vein graft failure remains a significant problem. Moreover, there is a lack of pharmacological interventions proven to be effective in the treatment of late vein graft failure...
August 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28860790/evaluation-of-pain-during-endovenous-laser-ablation-of-the-great-saphenous-vein-with-ultrasound-guided-femoral-nerve-block
#19
Abdullah M Al Wahbi
BACKGROUND: Endoluminal laser ablation is now considered the method of choice for treating greater saphenous vein insufficiency. General anesthesia and peripheral nerve blocks with sedation have the risk of post-procedural delay in discharge and prolonged immobilization with the risk of deep vein thrombosis. The main pain experienced by patients during the procedure is during the laser ablation and the multiple needle punctures given along and around the great saphenous vein. The aim of our study was to evaluate the safety and efficacy of blocking the femoral nerve only under ultrasound-guidance without sedation, to reduce or prevent pain during injectable tumescent anesthesia in endovenous laser ablation of the greater saphenous vein...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28856946/spontaneous-hit-syndrome-post-knee-replacement-surgery-with-delayed-recovery-of-thrombocytopenia-a-case-report-and-literature-review
#20
Dilli Ram Poudel, Sushil Ghimire, Rashmi Dhital, Daniel A Forman, Theodore E Warkentin
Recently published reports have established a heparin-induced thrombocytopenia (HIT)-mimicking thromboembolic disorder without proximate heparin exposure, called spontaneous HIT syndrome. Although the pathophysiology remains unclear, anti-platelet factor 4 (PF4)/heparin antibodies possibly triggered by exposure to knee cartilage glycosaminoglycans or other non-heparin polyanions found on bacterial surfaces and nucleic acids have been postulated. We present a 53-year-old female receiving antithrombotic prophylaxis with aspirin following right total knee replacement surgery (without perioperative or any previous lifetime heparin exposure) who acutely presented with high-risk pulmonary embolism (PE) and right great saphenous vein thrombophlebitis on postoperative day (POD) 14; her platelet count at presentation was 13 × 10(9)/L...
September 2017: Platelets
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