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https://www.readbyqxmd.com/read/27932884/a-randomized-trial-of-aripiprazole-vs-blonanserin-for-the-treatment-of-acute-schizophrenia-and-related-disorders
#1
Taro Kishi, Yuki Matsuda, Shinji Matsunaga, Tomohiko Mukai, Masatsugu Moriwaki, Hideaki Tabuse, Kiyoshi Fujita, Nakao Iwata
OBJECTIVE: There has been no direct comparison of aripiprazole and blonanserin for schizophrenia treatment. We conducted a 24-week, rater-masked, randomized trial of aripiprazole (6-30 mg/d) vs blonanserin (4-24 mg/d) in schizophrenia patients who were not taking any antipsychotic medication for more than 2 weeks before enrollment (UMIN000011194). METHODS: The primary outcome measure for efficacy was improvement of Positive and Negative Syndrome Scale (PANSS) total score at week 24...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27930499/prevalence-and-risk-factors-of-prolonged-corrected-qt-interval-among-children-and-adolescents-treated-with-antipsychotic-medications-a-long-term-follow-up-in-a-real-world-population
#2
Inmaculada Palanca-Maresca, Belén Ruiz-Antorán, Gustavo Adolfo Centeno-Soto, Maria Azul Forti-Buratti, Ana Siles, Ana Usano, Cristina Avendaño-Solá
PURPOSE: This study aimed to describe the prevalence of corrected QT (QTc) interval disorders and the possible predisposing factors in children and adolescents treated with antipsychotic (AP) medications in a real-world population with a long-term follow-up. METHODS: Data were obtained from the SafEty of NeurolepTics in Infancy and Adolescence (SENTIA) registry (https://sentia.es). The SENTIA includes patients younger than 18 years who are currently taking or initiating treatment with AP medications and have agreed to participate in the registry...
December 7, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27930496/obsessive-compulsive-symptoms-associated-with-aripiprazole-treatment-in-bipolar-disorder-a-case-report
#3
Prashant Gupta, Rishab Gupta, Yatan Pal Singh Balhara
No abstract text is available yet for this article.
December 7, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27930495/risk-of-gambling-disorder-and-impulse-control-disorder-with-aripiprazole-pramipexole-and-ropinirole-a-pharmacoepidemiologic-study
#4
Mahyar Etminan, Mohit Sodhi, Ali Samii, Ric M Procyshyn, Michael Guo, Bruce C Carleton
BACKGROUND: Recently, the US Food and Drug Administration issued a warning regarding the potential risk of gambling disorder, but large epidemiologic studies are lacking. METHODS: We used a large health claims database from the United States and conducted a nested case-control study. Cases were defined as subjects newly diagnosed with gambling disorder or impulse control disorder. For each case, 10 controls were selected and matched to cases by age and follow-up time and calendar time...
December 7, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929269/aripiprazole-vs-placebo-or-haloperidol-for-schizophrenia
#5
Shahriar Zehtabchi
No abstract text is available yet for this article.
December 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27927736/multidimensional-assessment-of-functional-outcomes-in-schizophrenia-results-from-qualify-a-head-to-head-trial-of-aripiprazole-once-monthly-and-paliperidone-palmitate
#6
Steven G Potkin, Jean-Yves Loze, Carlos Forray, Ross A Baker, Christophe Sapin, Timothy Peters-Strickland, Maud Beillat, Anna-Greta Nylander, Peter Hertel, Simon Nitschky Schmidt, Anna Eramo, Karina Hansen, Dieter Naber
BACKGROUND: QUALIFY was a 28-week, randomized, open-label, head-to-head trial that assessed improvements across multiple measures in stable patients with schizophrenia with aripiprazole once-monthly 400 mg vs paliperidone palmitate. METHODS: Secondary effectiveness assessments included physician-rated readiness for work using the Work Readiness Questionnaire, the Clinical Global Impression-Severity and Clinical Global Impression-Improvement scales, and quality of life with the rater-blinded Heinrichs-Carpenter Quality of Life Scale...
December 8, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27914279/identification-and-quantification-of-4-methylethcathinone-4-mec-and-3-4-methylenedioxypyrovalerone-mdpv-in-hair-by-lc-ms-ms-after-chronic-administration
#7
Jean Claude Alvarez, Isabelle Etting, Emuri Abe, Antoine Villa, Nicolas Fabresse
4-Methylethcathinone (4-MEC) and 3,4-methylenedioxypyrovalerone (MDPV) are synthetic cathinones. The objective of this study was to develop a method in order to measure these compounds in hair of a patient. After decontamination, 20mg of hair were grinded and incubated in phosphate buffer pH 5.0 in presence of 100ng of MDMA-d5 used as internal standard. Double basic liquid-liquid extraction was performed. Samples were separated on a 1.9μm Hypersil GOLD PFP column (100×2.1mm) using gradient elution. Compounds were detected by a LCQ TSQ Vantage XP triple-quadrupole mass spectrometer...
November 24, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27911814/distinct-cortical-and-striatal-actions-of-a-%C3%AE-arrestin-biased-dopamine-d2-receptor-ligand-reveal-unique-antipsychotic-like-properties
#8
Nikhil M Urs, Steven M Gee, Thomas F Pack, John D McCorvy, Tama Evron, Joshua C Snyder, Xiaobao Yang, Ramona M Rodriguiz, Emiliana Borrelli, William C Wetsel, Jian Jin, Bryan L Roth, Patricio O'Donnell, Marc G Caron
The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunction. In this study, we investigate the potential for newly developed β-arrestin2 (βarr2)-biased D2R partial agonists to simultaneously target hyper- and hypodopaminergia. Using neuron-specific βarr2-KO mice, we show that the antipsychotic-like effects of a βarr2-biased D2R ligand are driven through both striatal antagonism and cortical agonism of D2R-βarr2 signaling...
December 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27895084/prescription-preferences-in-antipsychotics-and-attitude-towards-the-pharmaceutical-industry-in-belgium
#9
Stijn Cleymans, Manuel Morrens, Chris Bervoets
OBJECTIVES: The number of antipsychotic prescriptions are increasing rapidly worldwide, a trend which is mainly driven by the steep rise in second-generation antipsychotic (SGA) prescriptions. However, the success of SGA, compared with the older first-generation antipsychotics (FGAs), cannot be explained by evidence. Several studies concluded on equal efficacy of FGA and SGA on positive, negative and cognitive symptoms of schizophrenia. Next to that, the influence of the pharmaceutical industry on prescription behaviour has drawn considerable interest...
November 28, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27893286/cessation-of-nocturnal-enuresis-with-aripiprazole
#10
Saliha Kılınç, Arzu Hergüner, Sabri Hergüner
No abstract text is available yet for this article.
November 28, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27879654/early-antipsychotic-treatment-in-juvenile-rats-elicits-long-term-alterations-to-the-dopamine-neurotransmitter-system
#11
Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Prescription of antipsychotic drugs (APDs) to children has substantially increased in recent years. Whilst current investigations into potential long-term effects have uncovered some alterations to adult behaviours, further investigations into potential changes to neurotransmitter systems are required. The current study investigated potential long-term changes to the adult dopamine (DA) system following aripiprazole, olanzapine and risperidone treatment in female and male juvenile rats. Levels of tyrosine hydroxylase (TH), phosphorylated-TH (p-TH), dopamine active transporter (DAT), and D₁ and D₂ receptors were measured via Western blot and/or receptor autoradiography...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27875914/second-generation-antipsychotics-in-real-life-paediatric-patients-adverse-drug-reactions-and-clinical-outcomes-of-drug-switch
#12
Concetta Rafaniello, Marco Pozzi, Simone Pisano, Carmen Ferrajolo, Silvana Bertella, Liberata Sportiello, Carla Carnovale, Maria Giuseppa Sullo, Dario Cattaneo, Marta Gentili, Renata Rizzo, Antonio Pascotto, Elisa Mani, Laura Villa, Maria Pia Riccio, Serena Sperandeo, Renato Bernardini, Carmela Bravaccio, Emilio Clementi, Massimo Molteni, Francesco Rossi, Sonia Radice, Annalisa Capuano
OBJECTIVE: Gap in knowledge on benefit/risk ratio of second generation antipsychotics (SGA) in the paediatric population represents a challenge for the scientific community. This study aims to analyse all suspected adverse drug reactions (ADRs) to SGA observed during the study period; compare the safety profiles of risperidone and aripiprazole; evaluate the effect of switching from risperidone to aripiprazole or to a first generation antipsychotic (FGA). METHODS: Prospective analysis of spontaneously reported ADRs concerning 184 paediatric outpatients between 2012 and 2014...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27874070/waterborne-aripiprazole-blunts-the-stress-response-in-zebrafish
#13
Heloísa Helena de Alcantara Barcellos, Fabiana Kalichak, João Gabriel Santos da Rosa, Thiago Acosta Oliveira, Gessi Koakoski, Renan Idalencio, Murilo Sander de Abreu, Ana Cristina Varrone Giacomini, Michele Fagundes, Cristiane Variani, Mainara Rossini, Angelo L Piato, Leonardo José Gil Barcellos
Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#14
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#15
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27866695/does-formulation-matter-a-systematic-review-and-meta-analysis-of-oral-versus-long-acting-antipsychotic-studies
#16
REVIEW
Giovanni Ostuzzi, Irene Bighelli, Ryuhei So, Toshi A Furukawa, Corrado Barbui
Recently, many authors highlighted the potential advantages of a broader prescription of long-acting injectable antipsychotics (LAIs) based on various assumptions, including favorable pharmacokinetic features. In this systematic review, data from randomized controlled trials comparing LAIs versus the oral formulation of the same antipsychotic were meta-analyzed in order to ascertain whether the route of administration may be associated with a different efficacy and tolerability profile. Of 21 included studies, 18 contributed to the meta-analysis, providing data for risperidone, olanzapine, aripiprazole, zuclopenthixol, fluphenazine and haloperidol...
November 17, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27861318/prediction-of-an-optimal-dose-of-aripiprazole-in-the-treatment-of-schizophrenia-from-plasma-concentrations-of-aripiprazole-plus-its-active-metabolite-dehydroaripiprazole-at-week-1
#17
Goyo Nagai, Kazuo Mihara, Akifumi Nakamura, Kenji Nemoto, Shoko Kagawa, Takeshi Suzuki, Tsuyoshi Kondo
BACKGROUND: It has been suggested that a plasma trough concentration of aripiprazole plus its active metabolite, dehydroaripiprazole of 225 ng/mL is a threshold for a good therapeutic response in the treatment of acutely exacerbated patients with schizophrenia. The present study investigated whether or not an optimal dose of aripiprazole could be predicted from these concentrations at week 1. METHODS: The subjects were 26 inpatients with schizophrenia, who received aripiprazole once a day for three weeks...
November 16, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27854086/a-review-of-differences-in-clinical-characteristics-between-tardive-syndrome-induced-or-improved-by-aripiprazole-treatment
#18
Yen-Wen Chen, Ping-Tao Tseng
INTRODUCTION: Tardive syndrome is a troublesome complication secondary to the long-term usage of antipsychotic medication. At present, there is a lack of effective treatment for tardive syndrome. Aripiprazole has been used in the treatment of tardive syndrome, with some reports of a good response. However, other reports have suggested that tardive syndrome can actually be induced by aripiprazole. The aim of current study was to investigate whether aripiprazole is beneficial or harmful for the treatment of tardive syndrome in specific patients...
September 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27828697/aripiprazole-induced-hyperlipidemia-an-update
#19
Caroline Tarraf, Wadih J Naja
OBJECTIVE: To review the literature on the metabolic side effects of aripiprazole. Three cases of aripiprazole-induced hypertriglyceridemia are also presented. DATA SOURCES: A search was conducted of English-language articles and abstracts (meta-analyses, randomized controlled trials, clinical trials, naturalistic open-label trials, reviews, and case reports) published up to August 31, 2014, in electronic databases (PubMed, MEDLINE). STUDY SELECTION: Free-text and MeSH search keywords included aripiprazole, cholesterol, triglyceride, lipid profile, hyperlipidemia, and hypercholesterolemia and their differing terminations and combinations...
August 25, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27825323/prolactin-related-adverse-events-and-change-in-prolactin-levels-in-pediatric-patients-given-antipsychotics-for-schizophrenia-and-schizophrenia-spectrum-disorders-a-systematic-review
#20
Eric Druyts, Michael J Zoratti, Kabirraaj Toor, Ping Wu, Salmaan Kanji, Kiran Rabheru, Edward J Mills, Kristian Thorlund
BACKGROUND: Second-generation antipsychotics are commonly prescribed for pediatric patients with schizophrenia and schizophrenia spectrum disorders despite their lack of approval for use in children. Although considered a safer alternative to first-generation antipsychotics, there is evidence to suggest that second-generation antipsychotics may be associated with some adverse events as well as an increase in prolactin levels. The purpose of this review is to examine the risk of prolactin-related adverse events in pediatric patients using antipsychotics and to quantify changes in prolactin for this population...
November 9, 2016: BMC Pediatrics
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