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Katherine E Zychowski, Bethany Sanchez, Rodrigo P Pedrosa, Geraldo Lorenzi-Filho, Luciano F Drager, Vsevolod Y Polotsky, Matthew J Campen
BACKGROUND AND AIMS: Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. Continuous positive airway pressure (CPAP) is a clinical therapy that maintains airway patency and mitigates several symptoms of OSA. However, it is currently unknown whether CPAP therapy also reduces the overall inflammatory potential in the circulation; to address this in an unbiased manner, we applied a novel endothelial biosensor approach, the serum cumulative inflammatory potential (SCIP) assay...
September 22, 2016: Atherosclerosis
Eva Pross, Lavinia Soussoula, Ines Seitl, Domenico Lupo, Andreas Kuhn
C-tailed membrane proteins insert into the bilayer post-translationally because the hydrophobic anchor segment leaves the ribosome at the end of translation. Nevertheless, we find here evidence that the targeting of SciP to the membrane of Escherichia coli occurs co-translationally since signal elements in the N-terminal part of the SciP protein sequence are present. Two short hydrophobic sequences were identified that targeted a green fluorescent protein-SciP fusion protein to the membrane involving the signal recognition particle...
October 9, 2016: Journal of Molecular Biology
Kenneth R Nakazawa, Natalia N Egorova, John R Power, Peter L Faries, Ageliki G Vouyouka
OBJECTIVE: As part of the Surgical Care Improvement Project (SCIP), a national quality partnership of organizations including the Centers for Medicare and Medicaid Services and the Centers for Disease Control and Prevention implemented several perioperative guidelines regarding antibiotic, venous thromboembolism (VTE), and beta-blocker prophylaxis for surgical patients. We evaluated the effect of SCIP on in-hospital surgical site infections (SSI), graft infections, VTE, myocardial infarctions (MI), cardiac complications, mortality, and length of stay following elective major vascular surgery...
August 10, 2016: Annals of Vascular Surgery
Takumi Yamamoto, Takafumi Saito, Ryohei Ishiura, Takuya Iida
Total ankle arthroplasty (TAA) is becoming popular in patients with rheumatoid arthritis (RA)-associated ankle joint degeneration. However, ankle wound complications can occur after TAA, which sometimes requires challenging reconstruction due to anatomical complexity of the ankle. Superficial circumflex iliac artery (SCIA) perforator (SCIP) flap has been reported to be useful for various reconstructions, but no case has been reported regarding a chimeric SCIP flap for complex ankle reconstruction. We report a case of complex ankle defect successfully reconstructed with a free quadruple-component chimeric SCIP flap...
September 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Elliott Bennett-Guerrero, Harold S Minkowitz, Alvaro M Segura-Vasi, Jorge E Marcet, Jennifer A White, G Ralph Corey, Kent S Allenby
BACKGROUND: Despite numerous interventions promulgated by the Surgical Care Improve Project (SCIP) and other organizations, surgical site infection (SSI) continues to be a significant medical problem. DFA-02 is a novel bioresorbable modified-release gel consisting of both gentamicin (16.8 mg/mL) and vancomycin (18.8 mg/mL) to be applied during surgical incision closure for the prevention of SSIs. The following double-blind phase 2a trial was designed to test the safety and tolerability of DFA-02...
2016: Perioperative Medicine
Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda, Klaus-Armin Nave
Schwann cell development and peripheral nerve myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2). Here we show that transcriptional repression, mediated by the zinc-finger protein Zeb2 (also known as Sip1), is essential for differentiation and myelination. Mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin membranes. Zeb2-deficient Schwann cells continuously express repressors of lineage progression...
August 2016: Nature Neuroscience
Mark S Allen, Shanda H Blackmon, Francis C Nichols, Stephen D Cassivi, William S Harmsen, Bettie Lechtenberg, Karlyn Pierson, Dennis A Wigle, K Robert Shen
BACKGROUND: There are very few randomized trials confirming the belief that prolonged urinary catheterization increases urinary tract infections, and none of these have included a comparative analysis of patients with an epidural catheter in place. The aim of this prospective randomized trial was to determine if removal of the urinary catheter within 48 hours after a thoracic operation, as required by the Surgical Care Improvement Project (SCIP) Measure 9, leads to increases in urinary tract reintervention and lower rates of urinary tract infections...
September 2016: Annals of Thoracic Surgery
Ana M Sánchez-Torres, María Rosa Elosúa, Ruth Lorente-Omeñaca, Lucía Moreno-Izco, Victor Peralta, Joseph Ventura, Manuel J Cuesta
Cognitive impairment in psychosis is closely related to functional outcome, so research into psychotic disorders is focusing most effort on treatments for improving cognition. New treatments must show not only an improvement on neuropsychological tests but also in co-primary measures of cognition. The cognitive assessment interview (CAI) is an interview-based measure of cognition which assesses the impact of cognitive deficits in patients' daily lives. Information obtained from patients and their relatives is integrated into a rater composite score...
October 2016: European Archives of Psychiatry and Clinical Neuroscience
Troy D Moon, Caleb B Hayes, Meridith Blevins, Melanie L Lopez, Ann F Green, Lazaro González-Calvo, Omo Olupona
BACKGROUND: Malaria remains a major threat to some 3.2 billion persons globally. Malaria contributes heavily to the overall disease burden in Mozambique and is considered endemic. A cornerstone of Mozambique's vector control strategy has been to strive for universal coverage of insecticide-treated nets (ITN). METHODS: The study is a population-based cross-sectional survey of female heads-of-household in Zambézia Province, Mozambique conducted during August-September, 2010 and April-May, 2014...
2016: Malaria Journal
Thomas B Bemenderfer, Nigel L Rozario, Charity G Moore, Madhav A Karunakar
BACKGROUND: Perioperative myocardial infarctions and cardiac complications are leading causes of mortality after noncardiac surgery. In an effort to improve patient safety, the Surgical Care Improvement Project (SCIP) implemented guidelines concerning administration of β-blockers therapy aimed to reduce cardiac complications. METHODS: The Nationwide Inpatient Sample was queried for 759,819 elective total knee arthroplasties performed from 2003 to 2011. Incidence of cardiac complications, mortality, and risk factors for cardiac complications was determined before and after SCIP implementation...
September 2016: Journal of Arthroplasty
Sharon Manne, Laura Mee, Abraham Bartell, Stephen Sands, Deborah A Kashy
OBJECTIVE: Providing care to one's child during and after a hematopoietic stem cell transplant (HSCT) is a universally stressful experience, but few psychological interventions have been developed to reduce caregiver distress. The goal of this study was to test the efficacy of a brief cognitive-behavioral intervention delivered to primary caregivers. METHOD: Two hundred eighteen caregivers were assigned either best-practice psychosocial care (BPC) or a parent social-cognitive intervention program (P-SCIP)...
May 2016: Journal of Consulting and Clinical Psychology
Chunyue Ma, Zhuowei Tian, Evagelos Kalfarentzos, Yixin Zhang, Zhiyuan Zhang, Din Lam, Chenping Zhang, Yue He
OBJECTIVES: With microvascular reconstruction, different perforator flaps have been introduced for the treatment of head and neck defects. In light of this, the superficial circumflex iliac artery perforator (SCIP) flap was assessed for reconstruction after partial and hemiglossectomy. STUDY DESIGN: A total number of nine patients who received SCIP flap reconstruction for tongue defects were included in this study. Details on clinical features were collected, and postoperative functions and esthetic results were analyzed...
April 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Yue He, Shufang Jin, Zhuowei Tian, Zao Fang, Chunyue Ma, Xiaofeng Tao, Yixin Zhang, Weiliu Qiu, Zhiyuan Zhang, Chenping Zhang
PURPOSE: To assess the feasibility of superficial circumflex iliac artery perforator (SCIP) flap for oral maxillofacial reconstruction and evaluate computed tomography angiography (CTA) and color Doppler sonography (CDS) in mapping superficial circumflex iliac artery (SCIA) and its perforators. MATERIAL AND METHODS: Fifteen patients were carried out surgery. Perforator identification and the relationship between SCIA, deep circumflex iliac artery (DCIA) and superficial inferior epigastric artery (SIEA) were performed preoperatively and intra-operatively...
March 2016: Journal of Cranio-maxillo-facial Surgery
Xin Chen, Jae Woong Wang, Adele Salin-Cantegrel, Rola Dali, Stefano Stifani
Somatic motor neurons in the hypoglossal nucleus innervate tongue muscles controlling vital functions such as chewing, swallowing and respiration. Formation of functional hypoglossal nerve circuits depends on the establishment of precise hypoglossal motor neuron maps correlating with specific tongue muscle innervations. Little is known about the molecular mechanisms controlling mammalian hypoglossal motor neuron topographic map formation. Here we show that combinatorial expression of transcription factors Runx1, SCIP and FoxP1 defines separate mouse hypoglossal motor neuron groups with different topological, neurotransmitter and calcium-buffering phenotypes...
December 19, 2015: Brain Structure & Function
Christine V Kinnier, Mila H Ju, Thomas Kmiecik, Cindy Barnard, Terri Halverson, Anthony D Yang, Joseph Caprini, Lindsey Kreutzer, Karl Y Bilimoria
BACKGROUND: Postoperative venous thromboembolism (VTE) is important clinically, and VTE quality metrics are used in public reporting and pay-for-performance programs. However, current VTE outcome measures are not valid due to surveillance bias, and the Surgical Care Improvement Project (SCIP-VTE-2) process measure only requires prophylaxis within 24 hours of surgery. OBJECTIVES: We sought to (1) develop a novel measure of VTE prophylaxis that requires early ambulation, mechanical prophylaxis, and chemoprophylaxis throughout the hospitalization, and (2) compare hospital performance on the SCIP-VTE-2 process measure to this novel measure...
February 2016: Medical Care
Caroline Vintergaard Ott, Anne Juul Bjertrup, Johan Høy Jensen, Henrik Ullum, René Sjælland, Scot E Purdon, Eduard Vieta, Lars V Kessing, Kamilla W Miskowiak
BACKGROUND: Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. METHOD: Participants (n=53) with UD in partial or full remission and healthy control persons (n=103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures...
January 15, 2016: Journal of Affective Disorders
S Strobbe, K Van Landuyt, P Delaere, V Vander Poorten, C Vanclooster
BACKGROUND: The superficial circumflex iliac artery perforator (SCIP) flap, which is the most recent advance in free flap surgery, is described as an evolution of the conventional free groin flap. It has been applied to limb and penile reconstruction. The SCIP flap is versatile and has many advantages, but there are few reports on the application of the SCIP flap to head and neck defects. CASE REPORT: We used a SCIP flap for reconstruction after resection of an oral malignant tumor in two women, aged 43 and 55 years, who presented between 2010 and 2012 with squamous cell carcinoma of the right floor of the mouth and tongue...
2015: B-ENT
Michael N Jones
No abstract text is available yet for this article.
September 2015: Behavior Research Methods
Hidehiko Yoshimatsu, Takumi Yamamoto, Nobuko Hayashi, Motoi Kato, Takuya Iida, Isao Koshima
Free flap reconstruction of the foot and ankle can be challenging in that it must fulfill functional and esthetic demands. Injury of this region is often associated with fractures, and muscle flaps are sometimes preferred. Here we present a case of the use of superficial circumflex iliac artery (SCIA) chimeric flap for reconstruction of ankle complex wound. A 78-year-old lady sustained open fractures of the left distal tibia, fibula, and talus, with a 10 × 6 cm(2) soft-tissue defect over the lateral aspect of her left ankle due to an automobile accident...
October 29, 2015: Microsurgery
Takuya Iida, Takumi Yamamoto, Hidehiko Yoshimatsu, Naho Abe, Masato Tsuchiya, Naho Nemoto, Shoji Watanabe
Although a superficial circumflex iliac artery perforator (SCIP) flap has recently been widely used owing to its various advantages, reports on its use in the pediatric population are limited. A case of a supermicrosurgical reconstruction of a soft tissue defect of the ankle associated with the congenital deficiency of the tibia using a free sensate SCIP flap in a 1-year-old child has been presented. The correction of the valgus deformity of the ankle resulted in a soft tissue defect, which required flap coverage...
March 2016: Microsurgery
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