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PET/CT, colorectal metastases

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https://www.readbyqxmd.com/read/29249594/anatomic-versus-metabolic-tumor-response-assessment-after-radioembolization-treatment
#1
Jennifer M J Jongen, Charlotte E N M Rosenbaum, Manon N G J A Braat, Maurice A A J van den Bosch, Daniel Y Sze, Onno Kranenburg, Inne H M Borel Rinkes, Marnix G E H Lam, Andor F van den Hoven
PURPOSE: To assess applicability of metabolic tumor response assessment on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) after radioembolization (RE) in patients with colorectal liver metastases (CRLM) by comparison with one-dimensional size-based response assessment on MR imaging. MATERIALS AND METHODS: This prospective cohort study comprised 38 patients with CRLM undergoing RE. MR imaging and 18F-FDG PET/CT imaging were performed at baseline, 1 month (n = 38), and 3 months (n = 21)...
December 14, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29204427/natural-killer-cells-activity-in-a-metastatic-colorectal-cancer-patient-with-complete-and-long-lasting-response-to-therapy
#2
Alessandro Ottaiano, Maria Napolitano, Monica Capozzi, Salvatore Tafuto, Antonio Avallone, Stefania Scala
Here we report a case of a 70-year-old man who received adjuvant chemotherapy with fluorouracile, folinic acid and oxaliplatin after a left hemicolectomy for a stage IIIb adenocarcinoma in May 2009. During follow-up he de-veloped abdominal lymphnodes metastases evidenced by positron emission tomography- computed tomography (PET-CT) scan and increase of carcinoembryonic antigen (CEA) level. Chemotherapy with capecitabine, oxaliplatin and bevacizumab was started in April 2012. Restaging showed a complete response and normalization of CEA...
November 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29196021/advanced-imaging-to-predict-response-to-chemotherapy-in-colorectal-liver-metastases-a-systematic-review
#3
REVIEW
Rianne C J Beckers, Doenja M J Lambregts, Max J Lahaye, Sheng-Xiang Rao, Kelly Kleinen, Cecile Grootscholten, Geerard L Beets, Regina G H Beets-Tan, Monique Maas
BACKGROUND: The assessment of colorectal liver metastases (CRLM) after treatment with chemotherapy is challenging due to morphological and/or functional change without changes in size. The aim of this review was to assess the value of FDG-PET, FDG-PET-CT, CT and MRI in predicting response to chemotherapy in CRLM. METHODS: A systematic review was undertaken based on PRISMA statement. PubMed and Embase were searched up to October 2016 for studies on the accuracy of PET, PET-CT, CT and MRI in predicting RECIST or metabolic response to chemotherapy and/or survival in patients with CRLM...
November 28, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29120905/fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-pet-ct-can-predict-prognosis-in-patients-with-colorectal-cancer-after-curative-surgical-resection
#4
Jeong Won Lee, Moo-Jun Baek, Tae Sung Ahn, Sang Mi Lee
OBJECTIVE: This study investigated the relationship of fluorine-18-fluorodeoxyglucose (F-FDG) uptake of bone marrow (BM) on PET/computed tomography (PET/CT) with clinicopathologic factors and survival in patients with colorectal cancer. PATIENTS AND METHODS: The study retrospectively included 226 patients with colorectal cancer who underwent F-FDG PET/CT for staging workup and treated with curative surgical resection. The maximum F-FDG uptake of primary cancer (Tmax) and mean F-FDG uptake of BM [BM standardized uptake value (SUV)] were derived from PET/CT images...
November 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29034693/role-of-18-f-fdg-pet-ct-vs-ct-scan-in-patients-with-pulmonary-metastases-previously-operated-on-for-colorectal-liver-metastases
#5
Victor Lopez-Lopez, Ricardo Robles, Roberto Brusadin, Asuncion López Conesa, Juan Torres, Domingo Perez Flores, Jose Luis Navarro, Pedro Jose Gil, Pascual Parrilla
OBJECTIVE: There is currently no conclusive scientific evidence available regarding the role of the (18)F-FDG PET/CT for detecting pulmonary metastases from colorectal cancer (PMCRC) in patients operated on for colorectal liver metastases (CRLM). In the follow up of patients who underwent surgery for CRLM, we compare CT-scan and (18)F-FDG PET/CT in patients with PMCRC. METHODS: We designed the study prospectively performing an (18)F-FDG PET/CT on all patients operated on for CRLM where the CT-scan detected PMCRC during the follow up...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29026950/the-prognostic-value-of-18-f-fdg-pet-ct-prior-to-liver-transplantation-for-nonresectable-colorectal-liver-metastases
#6
Harald Grut, Svein Dueland, Pål Dag Line, Mona Elisabeth Revheim
PURPOSE: The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29025986/-18-f-fluorodeoxyglycose-avid-thyroid-incidentalomas-the-importance-of-contextual-interpretation
#7
David A Pattison, Michael Bozin, Alexandra Gorelik, Michael S Hofman, Rodney J Hicks, Anita Skandarajah
Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). This study aims to assess the overall and thyroid cancer specific survival in a large cohort of patients with FDG-avid TI with long-term follow-up to assess the validity of this approach...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28964611/incidental-detection-of-colorectal-lesions-by-fdg-pet-ct-scans-in-melanoma-patients
#8
Christopher J Young, Assad Zahid, Ian Choy, John F Thompson, Robyn P M Saw
BACKGROUND: Increased use of PET/CT scans in oncology patients has raised detection of Colorectal incidentalomas (CIs). The frequency and diagnostic outcomes of identifying these lesions in melanoma patients have not previously been studied. This studies primary objective was to determine the prevalence of CIs found on PET/CT scans in melanoma patients. The secondary objectives were to correlate the PET/CT findings with the pathology found at colonoscopy, and identify which patients were referred for colonoscopy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28916623/efficacy-of-radioembolization-with-holmium-166-microspheres-in-salvage-patients-with-liver-metastases-a-phase-2-study
#9
Jip F Prince, Maurice A A J van den Bosch, J F W Nijsen, Maarten L J Smits, Andor F van den Hoven, Stavros Nikolakopoulos, Frank J Wessels, Rutger C G Bruijnen, Manon Braat, Bernard A Zonnenberg, Marnix Lam
Rationale: Radioembolization of liver malignancies with holmium-166 (166Ho) microspheres has been shown safe in a phase 1 dose-escalation study. The purpose of this study was to investigate the efficacy of 166Ho radioembolization. Methods: In this prospective single-arm study, 56 patients were enrolled, all with liver metastases refractory to systemic therapy and ineligible for surgical resection. Radioembolization was performed with a projected average absorbed dose of 60 Gy to the liver (equal to 3.8 GBq/kg liver tissue)...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28815337/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-as-an-objective-substitute-for-ct-morphologic-response-criteria-in-patients-undergoing-chemotherapy-for-colorectal-liver-metastases
#10
Yujiro Nishioka, Ryuji Yoshioka, Wataru Gonoi, Toshitaka Sugawara, Shuntaro Yoshida, Masaji Hashimoto, Junichi Shindoh
PURPOSE: The computed tomography (CT) morphologic response of colorectal liver metastases (CLM) after chemotherapy is reportedly correlated with pathologic response and survival outcomes of patients undergoing surgery. However, they are rather subjective criteria and not evaluable without adequate quality of contrast-enhanced CT images. This study sought the potential use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) as an objective substitute for predicting pathological viability of CLM after chemotherapy...
August 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28760464/low-accuracy-of-computed-tomography-and-positron-emission-tomography-to-detect-lung-and-lymph-node-metastases-of-colorectal-cancer
#11
Francesco Guerrera, Stéphane Renaud, Mickaël Schaeffer, Victor Nigra, Paolo Solidoro, Nicola Santelmo, Pier Luigi Filosso, Pierre-Emmanuel Falcoz, Enrico Ruffini, Alberto Oliaro, Gilbert Massard
BACKGROUND: Minimally invasive surgery, stereotactic radiotherapy, and radiofrequency ablation are commonly proposed in the case of pulmonary colorectal-metastasis as alternatives to conventional open surgery. Preoperative imaging assessment by computed tomography (CT) scan and fluorodeoxyglucose positron emission tomography (FDG-PET) are critical to guide oncologic radical treatment. Our aim was to investigate the accuracy of CT and FDG-PET for the evaluation of the number of pulmonary colorectal metastases and thoracic lymph nodal involvement (LNI)...
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28695424/flt-pet-for-early-response-evaluation-of-colorectal-cancer-patients-with-liver-metastases-a-prospective-study
#12
Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind, Andreas Kjaer
BACKGROUND: Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study was to evaluate whether FLT-PET can be used for the early evaluation of treatment response in colorectal cancer patients (CRC) with liver metastases. Patients with metastatic CRC having at least one measurable (>1 cm) liver metastasis receiving first-line chemotherapy were included...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28681367/expandable-metallic-stent-for-endobronchial-metastasis-from-colorectal-cancer-reports-of-2-cases
#13
Tomoki Nakamura, Takayuki Tajima, Takashi Ogimi, Hiroshi Miyakita, Miho Nitta, Kazunori Myojin, Sakurako Tajiri, Ichiro Kobayashi, Takayuki Nishi, Sotaro Sadahiro, Hideo Shimada
In recent years, there have been many reports about the efficacy of stenting for central bronchial stenosis. When central bronchial stenosis is due to metastasis of a malignant tumor to the trachea and/or bronchi (endobronchial metastasis: EM), it is classified as "narrow EM" and "broad EM." [1] We managed two patients in whom bilateral stent placement was required for narrow and broad EM arising from colorectal cancer. Case 1: In September 2011, a 66-year-old man underwent low anterior resection for advanced colorectal cancer associated with unresectable liver metastasis...
July 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28680207/rectal-carcinoma-metastases-to-multiple-skeletal-muscles-role-of-f-18-fdg-pet-ct
#14
Meghana Prabhu, Sunil Hejjaji Venkataramarao Nalini Raju, Hemant Sachani
Rectal carcinoma with metastasis to skeletal muscle is rare. So far, 16 cases of skeletal muscle metastasis from colorectal carcinoma have been documented of which only 5 were rectal carcinomas.([1]) We discuss here the case of a 69-year old male, a known case of mucinous adenocarcinoma status post neoadjuvant chemoradiotherapy and abdomino perineal resection, who presented with low backache 4 months post surgery. He was found to have metastasis to multiple skeletal muscles without the involvement of common sites, such as liver and lung...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28670185/presentation-of-unusual-tracheal-metastasis-on-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-after-9-years-in-postnephrectomy-patient-of-renal-cell-carcinoma-a-case-report-and-review-of-literature
#15
Rahul Vithalrao Parghane, Ashwani Sood, Kim Vaiphei, Ashutosh Nath Aggarwal, Bhagwant Rai Mittal
Tracheal metastases from renal cell carcinoma (RCC) are extremely rare. Most common primary malignancy metastasizing to this unusual location usually comes from lung region while it is rare to have tracheal metastases from nonpulmonary malignancies such as breast, thyroid, colorectal carcinoma, and melanoma. The lesions detected on fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) scan, especially in the head and neck region, soft tissue, and muscular compartment during follow-up of RCC patients raise the possibility of metastatic lesions in these regions, though rarely encountered...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28625649/investigation-of-patterns-of-nodal-metastases-in-braf-mutant-lung-cancer
#16
S H McEvoy, D F Halpenny, A Viteri-Jusué, S A Hayes, A J Plodkowski, G J Riely, M S Ginsberg
Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). A recent study identified a highly unusual pattern of metastatic spread to axLN in patients with BRAF mutated colorectal cancer (CRC). The purpose of the study is to assess the incidence of axLN metastases in BRAF mutated NSCLC. Baseline computed tomography (CT) imaging at diagnosis and all follow up CTs of patients with BRAF mutated NSCLC treated at our institution were retrospectively reviewed by two radiologists for evidence of axLN metastases...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28571704/percutaneous-radiofrequency-ablation-of-lung-metastases-from-colorectal-carcinoma-under-c-arm-cone-beam-ct-guidance
#17
G Amouyal, S Pernot, C Déan, B Cholley, F Scotté, M Sapoval, O Pellerin
PURPOSE: The aim of this study was to assess the feasibility, safety and efficacy of percutaneous radiofrequency ablation of lung metastases from colorectal carcinoma using C-arm cone beam computed tomography (CBCT) guidance. MATERIAL AND METHODS: This single-center prospective observational study was performed from August 2013 to August 2016, and included consecutive patients referred for radiofrequency ablation of lung metastases from colorectal cancer. Radiofrequency ablation procedures were performed under C-arm CBCT guidance...
May 29, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28536968/clinical-and-imaging-based-prognostic-factors-in-radioembolisation-of-liver-metastases-from-colorectal-cancer-a-retrospective-exploratory-analysis
#18
Kathy P Willowson, Aimee R Hayes, David L H Chan, Michael Tapner, Elizabeth J Bernard, Richard Maher, Nick Pavlakis, Stephen J Clarke, Dale L Bailey
BACKGROUND: The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [(90)Y]-resin microspheres and to explore possible clinical and imaging derived prognostic factors. METHODS: FDG PET/CT was used to measure response of individual lesions to a measured absorbed dose, derived from post-treatment (90)Y PET imaging. Predicted dose was also derived from planning [(99m)Tc]-MAA SPECT data...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28525451/metastases-from-colorectal-cancer-avid-on-68ga-psma-pet-ct
#19
Lise Hangaard, Mads Ryø Jochumsen, Mikkel Holm Vendelbo, Kirsten Bouchelouche
Ga-PSMA PET/CT is currently used for detection of prostate cancer including metastases, even at low prostate-specific antigen values. A grown number of reports have shown increased uptake of PSMA in neovessels of nonprostatic malignancies including lung cancer, and recently a case report has demonstrated increased PSMA uptake in colorectal adenocarcinoma. In this case report, we demonstrate increased Ga-PMSA uptake on PET/CT in metastases from previously treated colon adenocarcinoma, and it illustrates the importance of histology of suspicious lesions on Ga-PSMA PET/CT...
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28490986/image-guided-sbrt-for-multiple-liver-metastases-with-exactrac-%C3%A2-adaptive-gating
#20
Carmen Rubio, Ovidio Hernando-Requejo, Daniel Zucca Aparicio, María ALlona Krauel, Mercedes López Gonzalez, Juan María Pérez, Emilio Sánchez Saugar, Pedro Fernández Letón
AIM: To report the outcome and toxicity of sequential stereotactic body radiotherapy (SBRT) for multiple liver metastases in patients treated with ExacTrac Adaptive Gating. BACKGROUND: In selected patients with a limited number of liver metastases, SBRT has been evaluated as a safe and effective treatment, with minimal toxicity and high rates of local control. MATERIALS AND METHODS: From April 2008 to October 2013, 21 patients with multiple (3-14) liver metastases (n = 101) were treated sequentially with SBRT at our institution...
March 2017: Reports of Practical Oncology and Radiotherapy
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