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https://www.readbyqxmd.com/read/28821985/impact-of-processing-methods-on-urinary-biomarkers-analysis-in-neonates
#1
Michelle C Starr, David J Askenazi, Stuart L Goldstein, James W MacDonald, Theo K Bammler, Zahra Afsharinejad, Patrick D Brophy, Sandra E Juul, Dennis E Mayock, Sangeeta R Hingorani
BACKGROUND: In neonates, the validation of urinary biomarkers to diagnose acute kidney injury is a rapidly evolving field. The neonatal population poses unique challenges when assessing the collection, storage, and processing of urinary samples for biomarker analysis. Given this, establishing optimal and consistent sample processing in this population for meaningful use in ongoing clinical trials is important. METHODS: Urine from a cohort of 19 hospitalized neonatal intensive care unit patients enrolled in the Preterm Erythropoietin Neuroprotection Trial (Clinical Trial NCT01378273) was collected for biomarker analysis by indirect techniques using Fisher-brand cotton balls placed in the diapers...
August 19, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28821017/the-location-of-australian-buruli-ulcer-lesions-implications-for-unravelling-disease-transmission
#2
Arvind Yerramilli, Ee Laine Tay, Andrew J Stewardson, Peter G Kelley, Emma Bishop, Grant A Jenkin, Mike Starr, Janine Trevillyan, Andrew Hughes, N Deborah Friedman, Daniel P O'Brien, Paul D R Johnson
BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. METHODS: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28803718/total-neoadjuvant-therapy-a-shifting-paradigm-in-locally-advanced-rectal-cancer-management
#3
REVIEW
Aaron J Franke, Hiral Parekh, Jason S Starr, Sanda A Tan, Atif Iqbal, Thomas J George
Colorectal carcinoma is the second leading cause of cancer-related deaths in the United States, with rectal cancer accounting for approximately one-third of newly diagnosed cases, thus representing a major socioeconomic health burden. Although minimally invasive procedures (ie, transanal excision) may be appropriate for a subset of patients with small, superficially invasive tumors, a more comprehensive trimodality approach with neoadjuvant chemoradiotherapy, total mesorectal excision, and systemic chemotherapy is recommended for medically operable patients with nonmetastatic, locally advanced rectal cancer (LARC)...
June 27, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28798487/epitaxial-thin-films-of-pyrochlore-iridate-bi2-xir2-yo7-%C3%AE-structure-defects-and-transport-properties
#4
W C Yang, Y T Xie, W K Zhu, K Park, A P Chen, Y Losovyj, Z Li, H M Liu, M Starr, J A Acosta, C G Tao, N Li, Q X Jia, J J Heremans, S X Zhang
While pyrochlore iridate thin films are theoretically predicted to possess a variety of emergent topological properties, experimental verification of these predictions can be obstructed by the challenge in thin film growth. Here we report on the pulsed laser deposition and characterization of thin films of a representative pyrochlore compound Bi2Ir2O7. The films were epitaxially grown on yttria-stabilized zirconia substrates and have lattice constants that are a few percent larger than that of the bulk single crystals...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28768411/larval-red-drum-sciaenops-ocellatus-sublethal-exposure-to-weathered-deepwater-horizon-crude-oil-developmental-and-transcriptomic-consequences
#5
Elvis Genbo Xu, Alex J Khursigara, Jason Magnuson, E Starr Hazard, Gary Hardiman, Andrew J Esbaugh, Aaron P Roberts, Daniel Schlenk
The Deepwater Horizon (DWH) incident resulted in extensive oiling of the pelagic zone and shoreline habitats of many commercially important fish species. Exposure to the water-accommodated fraction (WAF) of oil from the spill causes developmental toxicity through cardiac defects in pelagic fish species. However, few studies have evaluated the effects of the oil on near-shore estuarine fish species such as red drum (Sciaenops ocellatus). Following exposure to a certified weathered slick oil (4.74 μg/L ∑PAH50) from the DWH event, significant sublethal impacts were observed ranging from impaired nervous system development [average 17 and 22% reductions in brain and eye area at 48 h postfertilization (hpf), respectively] to abnormal cardiac morphology (100% incidence at 24, 48, and 72 hpf) in red drum larvae...
August 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28764372/influence-of-sample-preparation-on-the-transformation-of-low-density-to-high-density-amorphous-ice-an-explanation-based-on-the-potential-energy-landscape
#6
Nicolas Giovambattista, Francis W Starr, Peter H Poole
Experiments and computer simulations of the transformations of amorphous ices display different behaviors depending on sample preparation methods and on the rates of change of temperature and pressure to which samples are subjected. In addition to these factors, simulation results also depend strongly on the chosen water model. Using computer simulations of the ST2 water model, we study how the sharpness of the compression-induced transition from low-density amorphous ice (LDA) to high-density amorphous ice (HDA) is influenced by the preparation of LDA...
July 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28764335/effects-of-a-bound-substrate-layer-on-the-dynamics-of-supported-polymer-films
#7
Wengang Zhang, Jack F Douglas, Francis W Starr
It is widely appreciated that an attractive polymer-substrate interaction can slow relaxation in thin supported polymer films and polymer nanocomposites. Recent measurements and simulations on nancomposites have indicated that this slowing of polymer dynamics occurs more strongly near a highly attractive particle surface where a "bound" layer having a much lower mobility can form, strongly influencing the thermodynamics and dynamics of the film. Here we use molecular simulations to show that a bound interfacial layer having a very similar nature arises in thin supported polymer films when the polymer-polymer attraction is stronger than the polymer-polymer interaction strength...
July 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28763405/suspected-pediatric-influenza-risk-stratification-algorithm-a-clinical-decision-tool
#8
Patrick D Evers, Michelle Starr, Michael J McNeil, Laura OʼNeill, Andrea Posa, Timothy Savage, Russell Migita
BACKGROUND AND OBJECTIVES: Influenza causes significant annual burden among children. Current guidelines recommend empiric treatment for a broadly defined group of children at high risk for influenza complications, resulting in overtreatment or costly viral testing. This study creates an algorithm for clinicians to risk stratify children with influenza-like illness (ILI) according to likelihood of influenza infection. METHODS: A retrospective analysis was performed on 818 children seen in the emergency department from November 2012 to April 2013 for ILI...
August 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28759970/a-novel-assessment-and-profiling-of-multidimensional-apathy-in-alzheimer-s-disease
#9
Ratko Radakovic, John M Starr, Sharon Abrahams
BACKGROUND: Apathy is a complex multidimensional syndrome frequently reported in Alzheimer's disease (AD) and is associated with impaired awareness. Here we present a psychometrically robust method to profile apathy in AD. OBJECTIVES: To determine the validity and reliability of a multidimensional apathy measure, the Dimensional Apathy Scale (DAS), and explore the apathy subtype profile and its associations in AD. METHODS: 102 people with AD and 55 healthy controls were recruited...
July 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28746705/risk-of-suicide-attempt-among-soldiers-in-army-units-with-a-history-of-suicide-attempts
#10
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Paul D Bliese, Alan M Zaslavsky, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Murray B Stein
Importance: Mental health of soldiers is adversely affected by the death and injury of other unit members, but whether risk of suicide attempt is influenced by previous suicide attempts in a soldier's unit is unknown. Objective: To examine whether a soldier's risk of suicide attempt is influenced by previous suicide attempts in that soldier's unit. Design, Setting, and Participants: Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS), this study identified person-month records for all active-duty, regular US Army, enlisted soldiers who attempted suicide from January 1, 2004, through December 31, 2009 (n = 9650), and an equal-probability sample of control person-months (n = 153 528)...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28736080/the-effect-of-ankle-foot-orthosis-alignment-on-walking-in-individuals-treated-for-traumatic-lower-extremity-injuries
#11
Starr E Brown, Elizabeth Russell Esposito, Jason M Wilken
Limb salvage surgeries are performed to treat a variety of lower limb pathologies and traumatic injuries. Individuals who have undergone limb salvage surgeries may require an ankle foot orthosis (AFO) to compensate for limb impairments and restore walking ability. Understanding the effects of AFO design parameters on gait biomechanics is important to refine AFO prescription criteria. In this study sagittal plane kinematic and kinetic data, muscle activity and alignment preference were examined as individuals treated for traumatic lower extremity injuries (N=12) walked over level ground with Plantarflexed (PF), Neutral, and Dorsiflexed (DF) aligned AFOs...
July 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28718931/army-soldiers-and-suicidal-thoughts-the-impact-of-negative-relationship-dynamics-moderated-by-the-dissolution-of-romantic-relationships
#12
Heather A Love, Jared A Durtschi, Lauren M Ruhlmann, Briana S Nelson Goff
Suicide among United States active-duty Army soldiers rapidly increased over the past two decades. Using a sample of 322 soldiers from the Army STARRS study, the researchers examined if romantic relationship factors (i.e., hostile disagreements and relationship distress) were linked with suicidal thoughts in Army soldiers, and if these associations were moderated by a recent separation or divorce. Hostile disagreements and relational distress were both significantly associated with higher rates of suicidal ideation...
July 18, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28717517/knowledge-mapping-visualization-analysis-of-the-military-health-and-medicine-papers-published-in-the-web-of-science-over-the-past-10%C3%A2-years
#13
Xuan-Ming Zhang, Xuan Zhang, Xu Luo, Hai-Tao Guo, Li-Qun Zhang, Ji-Wei Guo
BACKGROUND: Military medicine is a research field that seeks to solve the medical problems that occur in modern war conditions based on public medicine theory. METHODS: We explore the main research topics of military health and medical research in the web of science™ core collection (WoSCC) from 2007 to 2016, and the goal of this work is to serve as a reference for orientation and development in military health and medicine. Based on CiteSpace III, a reference co-citation analysis is performed for 7921 papers published in the WoSCC from 2007 to 2016...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28715967/hyperthermia-enhanced-targeted-drug-delivery-using-magnetic-resonance-guided-focussed-ultrasound-a-pre-clinical-study-in-a-genetic-model-of-pancreatic-cancer
#14
Navid Farr, Yak-Nam Wang, Samantha D'Andrea, Frank Starr, Ari Partanen, Kayla M Gravelle, Jeannine S McCune, Linda J Risler, Stella G Whang, Amy Chang, Sunil R Hingorani, Donghoon Lee, Joo Ha Hwang
PURPOSE: The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate of just 8%. Here, we evaluate the ability to enhance targeted drug delivery using mild hyperthermia in combination with the systemic administration of a low-temperature sensitive liposomal formulation of doxorubicin (LTSL-Dox) using a relevant model for pancreas cancer. MATERIALS AND METHODS: Experiments were performed in a genetically engineered mouse model of pancreatic cancer (KPC mice: LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre)...
July 17, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28715669/the-contributions-of-numerical-acuity-and-non-numerical-stimulus-features-to-the-development-of-the-number-sense-and-symbolic-math-achievement
#15
Ariel Starr, Nicholas K DeWind, Elizabeth M Brannon
Numerical acuity, frequently measured by a Weber fraction derived from nonsymbolic numerical comparison judgments, has been shown to be predictive of mathematical ability. However, recent findings suggest that stimulus controls in these tasks are often insufficiently implemented, and the proposal has been made that alternative visual features or inhibitory control capacities may actually explain this relation. Here, we use a novel mathematical algorithm to parse the relative influence of numerosity from other visual features in nonsymbolic numerical discrimination and to examine the strength of the relations between each of these variables, including inhibitory control, and mathematical ability...
July 14, 2017: Cognition
https://www.readbyqxmd.com/read/28703280/the-oregonheart-total-artificial-heart-design-and-performance-on-a-mock-circulatory-loop
#16
Jeremy Glynn, Howard Song, Bryan Hull, Stanley Withers, Jill Gelow, James Mudd, Albert Starr, Richard Wampler
Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles between two positions to provide pulsatile, alternating blood flow to the systemic and pulmonary circulations without artificial valves. Flow rates and pressures generated by the TAH are controlled by adjusting rotor speed, cycle frequency, and the proportion of each cycle spent pumping to either circulation...
July 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28702169/exome-sequencing-reveals-independent-sgcd-deletions-causing-limb-girdle-muscular-dystrophy-in-boston-terriers
#17
Melissa L Cox, Jacquelyn M Evans, Alexander G Davis, Ling T Guo, Jennifer R Levy, Alison N Starr-Moss, Elina Salmela, Marjo K Hytönen, Hannes Lohi, Kevin P Campbell, Leigh Anne Clark, G Diane Shelton
BACKGROUND: Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described in several breeds of dogs, but the responsible mutations are unknown. The clinical presentation in dogs is characterized by marked muscle weakness and atrophy in the shoulder and hips during puppyhood. METHODS: Following clinical evaluation, the identification of the dystrophic histological phenotype on muscle histology, and demonstration of the absence of sarcoglycan-sarcospan complex by immunostaining, whole exome sequencing was performed on five Boston terriers: one affected dog and its three family members and one unrelated affected dog...
2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28697784/exome-sequencing-reveals-independent-sgcd-deletions-causing-limb-girdle-muscular-dystrophy-in-boston-terriers
#18
Melissa L Cox, Jacquelyn M Evans, Alexander G Davis, Ling T Guo, Jennifer R Levy, Alison N Starr-Moss, Elina Salmela, Marjo K Hytönen, Hannes Lohi, Kevin P Campbell, Leigh Anne Clark, G Diane Shelton
BACKGROUND: Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described in several breeds of dogs, but the responsible mutations are unknown. The clinical presentation in dogs is characterized by marked muscle weakness and atrophy in the shoulder and hips during puppyhood. METHODS: Following clinical evaluation, the identification of the dystrophic histological phenotype on muscle histology, and demonstration of the absence of sarcoglycan-sarcospan complex by immunostaining, whole exome sequencing was performed on five Boston terriers: one affected dog and its three family members and one unrelated affected dog...
July 11, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28697317/management-of-malignant-bowel-obstruction-associated-with-gi-cancers
#19
Aaron J Franke, Atif Iqbal, Jason S Starr, Rajesh M Nair, Thomas J George
For many patients with GI malignancies, the seeding of the abdominal cavity with tumor cells, called peritoneal carcinomatosis, is a common mode of metastases and disease progression. Prognosis for patients with this aspect of their disease remains poor, with high disease-related morbidity and complications. Uniform and proven practices that provide optimal palliative care and quality of life for these patients are needed. The objective of this review is to critically assess the current literature regarding palliative strategies in the management of peritoneal carcinomatosis and associated symptoms in patients with advanced GI cancers...
July 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28696945/correction-the-complex-genetics-of-gait-speed-genome-wide-meta-analysis-approach
#20
Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L Lunetta, Jennifer A Smith, John D Eicher, Rotem Vered, Joris Deelen, Alice M Arnold, Aron S Buchman, Toshiko Tanaka, Jessica D Faul, Maria Nethander, Myriam Fornage, Hieab H Adams, Amy M Matteini, Michele L Callisaya, Albert V Smith, Lei Yu, Philip L De Jager, Denis A Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J Launer, Davis S Knopman, Neeta Parimi, Stephen T Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P Mooijaart, David C Liewald, Jeanine J Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J Verlinden, Dan Mellström, Jos N van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J Tranah, Andre G Uitterlinden, David R Weir, Wei Zhao, John M Starr, Andrew D Johnson, M Arfan Ikram, David A Bennett, Steven R Cummings, Ian J Deary, Tamara B Harris, Sharon L R Kardia, Thomas H Mosley, Velandai K Srikanth, Beverly G Windham, Ann B Newman, Jeremy D Walston, Gail Davies, Daniel S Evans, Eline P Slagboom, Luigi Ferrucci, Douglas P Kiel, Joanne M Murabito, Gil Atzmon
No abstract text is available yet for this article.
July 7, 2017: Aging
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