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Janeen H Trembley, Betsy T Kren, Md Joynal Abedin, Rachel I Vogel, Claire M Cannon, Gretchen M Unger, Khalil Ahmed
Protein kinase CK2 demonstrates increased protein expression relative to non-transformed cells in the majority of cancers that have been examined. The elevated levels of CK2 are involved in promoting not only continued proliferation of cancer cells but also their resistance to cell death; thus, CK2 has emerged as a plausible target for cancer therapy. Our focus has been to target CK2 catalytic subunits at the molecular level using RNA interference (RNAi) strategies to achieve their downregulation. The delivery of oligonucleotide therapeutic agents warrants that they are protected and are delivered specifically to cancer cells...
February 21, 2017: Pharmaceuticals
Ping Huang, Yu Chen, Han Lin, Luodan Yu, Linlin Zhang, Liying Wang, Yufang Zhu, Jianlin Shi
Based on the intrinsic features of high stability and unique multifunctionality, inorganic nanoparticles have shown remarkable potentials in combating cancer, but their biodegradability and biocompatibility are still under debate. As a paradigm, this work successfully demonstrates that framework organic-inorganic hybridization can endow the inorganic mesoporous silica nanocarriers with unique tumor-sensitive biodegradability and high biocompatibility. Based on a "chemical homology" mechanism, molecularly organic-inorganic hybridized hollow mesoporous organosilica nanocapsules (HMONs) with high dispersity and sub-50 nm particle dimension were constructed in mass production...
February 15, 2017: Biomaterials
Marwa Elewa, Nadica Maltar-Strmečki, Mohamed M Said, Hosam A El Shihawy, Mohamed El-Sadek, Juliane Frank, Simon Drescher, Malte Drescher, Karsten Mäder, Dariush Hinderberger, Peter Imming
A hydrophilic tris(tetrachlorotriaryl)methyl (tetrachloro-TAM) radical labelled 50% with (13)C at the central carbon atom was prepared. The mixture of isotopologue radicals was characterised by continuous wave and pulsed X-band electron paramagnetic spectroscopy (EPS). For the pharmaceutical and medical applications planned, the quantitative influence of oxygen, viscosity, temperature and pH on EPR line widths was studied in aqueous buffer, DMSO, water-methanol and water-glycerol mixtures. Under in vivo conditions, pH can be disregarded...
February 17, 2017: Physical Chemistry Chemical Physics: PCCP
Aritz Perez Ruiz de Garibay, Cinzia Spinato, Rebecca Klippstein, Maxime Bourgognon, Markus Martincic, Elzbieta Pach, Belén Ballesteros, Cécilia Ménard-Moyon, Khuloud T Al-Jamal, Gerard Tobias, Alberto Bianco
This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty amino-functionalized CNTs [SWCNT-NH2 (1)] or samarium chloride-filled amino-functionalized CNTs with [SmCl3@SWCNT-mAb (3)] or without [SmCl3@SWCNT-NH2 (2)] Cetuximab functionalization were tested. Conjugates were added to RAW 264.7 or PBMC cells in a range of 1 μg/ml to 100 μg/ml for 24 h. Cell viability and IL-6/TNFα production were determined by flow cytometry and ELISA...
February 15, 2017: Scientific Reports
Ju E Morozova, V V Syakaev, Ya V Shalaeva, A M Ermakova, I R Nizameev, M K Kadirov, A D Voloshina, V V Zobov, I S Antipin, A I Konovalov
The association of cetylpyridinium chloride (CPC) micelles in the presence of octaacetated tetraphenyleneoxymethylcalix[4]resorcinarene (CR) leads to the formation of unusual spherical supramolecular nanoparticles (SNPs). Within the range of CR/CPC molar ratios from 10/1 to 1/10 (except for 1/8), CR, acting as a counterion, decreases the critical micelle concentration of CPC by one order of magnitude and leads to the formation of SNPs with an average hydrodynamic radius of 164 nm and an average zeta potential of -60 mV...
February 15, 2017: Soft Matter
Carine F Souza, Matheus D Baldissera, Luciana F Cossetin, Daiane F Dalla Lana, Silvia G Monteiro
Oxidative stress has been considered as a pathological mechanism that contributes to initiation and progression of cardiac injury during the Trypanosoma evansi infection. In this sense, the natural compounds with antioxidant and free radical scavenger abilities, such the Achyrocline satureioides essential oil loaded in nanocapsules (AS-NC), may be considered important approach to minimize the cardiac damage. Thus, the aim of this study was to investigate whether AS-NC treatment is able to prevents or reduce the cardiac oxidative damage in infected rats with T...
February 6, 2017: Microbial Pathogenesis
Chen Zhang, Rahul S Patil, Chong Liu, Charles L Barnes, Jerry L Atwood
Two-dimensional framework of nickel-seamed hexameric metal-organic nanocapsules have been synthesized by connecting the tailed hydroxyl groups of C-propan-3-ol pyrogallol[4]arene with adjacent hexameric capsules via nickel-hydroxyl coordination. In addition, functionalization of nanocapsules with multiple pyridine molecules at the capsule surface prevents them from assembling into hierar-chical structures and leads to the formation of discrete nickel-seamed pyrogallol[4]arene nanocapsules. This work shows that surface functionalization of nanocapsules is an effective and innovative method of controlling the assembly of these nanometric building blocks...
February 8, 2017: Journal of the American Chemical Society
Haotian Sun, Iven Yarovoy, Meghan Capeling, Chong Cheng
Recently, co-delivery of siRNA and anticancer drugs has drawn much attention in the treatment of drug-resistant cancers. Drug resistance is exhibited by cancer cells, which limits the efficacy of chemotherapy. When siRNA and anticancer drugs are delivered into cancer cells simultaneously, the siRNA is expected to silence the genes related to drug resistance, decreasing the drug efflux pumps and activating the cell's apoptosis pathways. In a timeframe following the release of siRNA, the accumulation of the co-delivered anti-cancer drug inside of the cancer cells will increase, resulting in promoted chemotherapeutic effects...
April 2017: Topics in Current Chemistry (Journal)
M Feng, L-X Zhong, Z-Y Zhan, Z-H Huang, J-P Xiong
OBJECTIVE: The aim of present work was to prepare resveratrol-loaded lipid-core-nanocapsule (RSV-LNC) and to characterize its ability to target the colon cancer cells. MATERIALS AND METHODS: The lipid-core nanocapsule was prepared by precipitation method. The nanoparticle was prepared and evaluated regarding physical, chemical and biological parameters. RESULTS: The average size of optimized nanocapsule was ~159 nm with a uniform size distribution index of 0...
January 2017: European Review for Medical and Pharmacological Sciences
Luiza A Frank, Paula S Chaves, Camilo M D'Amore, Renata V Contri, Alejandro G Frank, Ruy C R Beck, Adriana R Pohlmann, Andreia Buffon, Silvia S Guterres
The human papillomavirus (HPV) infection, which is strongly related to cervical cancer, can be reduced by the topical application of imiquimod. Some strategies have been used to increase the adhesion and penetration of drugs through the vaginal mucosa. Two of them are the development of mucoadhesive semisolid formulations and the development of polymeric nanocarriers. In this paper, we hypothesize that the combined use of these two strategies results in a better performance of the formulation to retain imiquimod into the vaginal tissue...
February 1, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Anamarija Ćurić, Jan Peter Möschwitzer, Gert Fricker
Treatment of cryptococcal meningitis with antifungals such as itraconazol is difficult due their low concentration in the brain. Therefore, drug carriers with high payload are highly desired. But, generation of itraconazole loaded poly(butyl cyanoacrylate) nanoparticles with higher drug load, for instance more than 20% drug, is challenging. In present study we were able to generate novel highly loaded itraconazole poly(butyl cyanoacrylate) nanocapsules containing up to 99% (w/w) itraconazole and 1% polymer (w/w)...
January 31, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Pauline Resnier, Natacha Galopin, Yann Sibiril, Anne Clavreul, Jérôme Cayon, Alessandro Briganti, Pierre Legras, Anne Vessières, Tristan Montier, Gérard Jaouen, Jean-Pierre Benoit, Catherine Passirani
Metastatic melanoma has been described as a highly aggressive cancer with low sensibility to chemotherapeutic agents. New types of drug, such as metal-based drugs (ferrocifens) have emerged and could represent an alternative for melanoma treatment since they show interesting anticancer potential. Furthermore, molecular analysis has evidenced the role of apoptosis in the low sensibility of melanomas and especially of the key regulator, Bcl-2. The objective of this study was to combine two strategies in the same lipid nanocapsules (LNCs): i) gene therapy to modulate anti-apoptotic proteins by the use of Bcl-2 siRNA, and ii) ferrocifens as a new type of anticancer agent...
January 31, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Tiffany C Kwong, Farouk Nouizi, Yuting Lin, Jaedu Cho, Yue Zhu, Uma Sampathkumaran, Gultekin Gulsen
Previously, we reported on the spatial resolution and quantitative accuracy of temperature-modulated fluorescence tomography (TM-FT) using simulation studies. TM-FT is a novel fully integrated multimodality imaging technique that combines fluorescence diffuse optical tomography (FT) with focused ultrasound. Utilizing unique thermo-reversible fluorescent nanocapsules (ThermoDots), TM-FT provides high-resolution cross-sectional fluorescence images in thick tissue (up to 6 cm). Focused ultrasound and temperature-sensitive ThermoDots are combined to provide accurate localization of these fluorescent probes and functional a priori information to constrain the conventional FT reconstruction algorithm...
January 20, 2017: Applied Optics
Dolores Melgar, Nuno A G Bandeira, Josep Bonet Avalos, Carles Bo
Keplerates are a family of anionic metal oxide spherical capsules containing up to 132 metal atoms and some hundreds of oxygen atoms. These capsules holding a high negative charge of -12 coordinate both mono-anionic and di-anionic ligands thus increasing their charge up to -42, even up to -72, which is compensated by the corresponding counter-cations in the X-ray structures. We present an analysis of the relative importance of several energy terms of the coordinate bond between the capsule and ligands like carbonate, sulphate, sulphite, phosphinate, selenate, and a variety of carboxylates, of which the overriding component is contributed by solvation/de-solvation effects...
February 3, 2017: Physical Chemistry Chemical Physics: PCCP
JinFeng Liao, XiaWei Wei, Bei Ran, JinRong Peng, Ying Qu, ZhiYong Qian
Developing multifunctional nanoparticle-based theranostic systems for personalized cancer diagnosis and treatment is highly desirable. Herein, a magnetic targeting theranostic nanocapsule (NC-SPIOs-IR820-PTX) was fabricated by hierarchically assembling superparamagnetic iron oxide nanoparticles (SPIOs), cyanine dye (IR820) and chemotherapeutic compound of paclitaxel (PTX) with poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA). The nanocapsules exhibited high stability and biocompatibility both in vitro and in vivo...
February 2, 2017: Nanoscale
Qi Tang, Li-Li Chen, Fen Wei, Wei-Lian Sun, Li-Hong Lei, Pei-Hui Ding, Jing-Yi Tan, Xiao-Tao Chen, Yan-Min Wu
BACKGROUND: 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules (15d-PGJ2-NC) on inflammatory responses and bone regeneration in local bone defect. METHODS: The study was conducted on 96 Wistar rats from June 2014 to March 2016...
2017: Chinese Medical Journal
Carles Fuertes-Espinosa, Cristina García-Simón, Edison Castro, Miquel Costas, Luis Echegoyen, Xavi Ribas
A self-assembled Cu(II) -based nanocapsule enables efficient and straightforward isolation of Sc3 N@C80 from arc-processed raw soot. The newly designed Cu(II) -based supramolecular nanocapsule 5⋅(OTf)8 was used to effectively entrap fullerenes and endohedral metallofullerenes (EMFs) with different affinities depending on their size and shape. Moreover, we took advantage of the sharply different entrapment abilities of the 5⋅(OTf)8 cage in the solid state versus in solution to encapsulate all the species with the exception of Sc3 N@C80 (both Ih and D5h isomers), which remains pure in solution...
January 30, 2017: Chemistry: a European Journal
Arthur de Castro Jorge Silva, Mariana Härter Remirão, Caroline Gomes Lucas, William Borges Domingues, Tony Silveira, Julia Dame Paschoal, Denise S Jornada, Carine Dahl Corcine, Antonio Sergio Varela Junior, Willian A Prado, Vinicius Farias Campos, Fabiana Kömmling Seixas, Silvia S Guterres, Adriana R Pohlmann, Tiago Collares
Toxicology studies have a pivotal role for selection of new nanosystems. As lipid-core nanocapsules (LNC) rise as a potential system not only for drug delivery but also for immunotherapy and gene therapy, the demand for models of toxic screening increases, and sperm arises as a promising model due to the easiness to evaluate its viability parameters. LNCs were coated with chitosan, chitosan-coated lipid-core nanocapsules (LNC-CS), in order to modify the nanocapsule surface. We evaluated the toxicity of LNC and LNC-CS after incubation with bovine sperm in different concentrations (2...
January 24, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Paula Dos Santos Chaves, Aline Ferreira Ourique, Luiza Abrahão Frank, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Ruy Carlos Ruver Beck
Carvedilol is a drug used to treat heart failure, hypertension, and coronary artery diseases . However, it has low oral bioavailability (25-35%) due to its high first-pass hepatic metabolism. The objective of this study was to develop carvedilol-loaded mucoadhesive nanocapsules as delivery systems for the sublingual administration of the drug. Nanocapsules were prepared using poly(ε-caprolactone) (CAR-LNC) and Eudragit® RS 100 (CAR-NC) as polymeric wall. In vitro interaction of formulations with mucin was performed to predict their mucoadhesion capacity...
January 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Xin Li, Lingxi Xing, Kailiang Zheng, Ping Wei, Lianfang Du, Mingwu Shen, Xiangyang Shi
Development of multifunctional nanoplatforms for tumor multimode imaging and therapy is of great necessity. Herein, we report a new type of Au nanostar (NS)-coated, perfluorohexane (PFH)-encapsulated hollow mesoporous silica nanocapsule (HMS) modified with poly(ethylene glycol) (PEG) for tumor multimode ultrasonic (US)/computed tomography (CT)/photoacoustic (PA)/thermal imaging, and photothermal therapy (PTT). HMSs were first synthesized, silanized to have thiol surface groups, and coated with gold nanoparticles via a Au-S bond...
February 22, 2017: ACS Applied Materials & Interfaces
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