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https://www.readbyqxmd.com/read/28533751/docetaxel-loaded-nanoparticles-assembled-from-%C3%AE-cyclodextrin-calixarene-giant-surfactants-physicochemical-properties-and-cytotoxic-effect-in-prostate-cancer-and-glioblastoma-cells
#1
Laura Gallego-Yerga, Inmaculada Posadas, Cristina de la Torre, Jesús Ruiz-Almansa, Francesco Sansone, Carmen Ortiz Mellet, Alessandro Casnati, José M García Fernández, Valentín Ceña
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module undergo self-assembly in aqueous media to afford core-shell nanospheres or nanocapsules, depending on the nanoprecipitation protocol, with high docetaxel (DTX) loading capacity. The blank and loaded nanoparticles have been fully characterized by dynamic light scattering (DLS), ζ-potential measurements and cryo-transmission electron microscopy (cryo-TEM). The data are compatible with the distribution of the drug between the nanoparticle core and the shell, where it is probably anchored by inclusion of the DTX aromatic moieties in βCD cavities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28526346/release-study-and-inhibitory-activity-of-thyme-essential-oil-loaded-chitosan-nanoparticles-and-nanocapsules-against-foodborne-bacteria
#2
M Sotelo-Boyás, Z Correa-Pacheco, S Bautista-Baños, Y Gómez Y Gómez
The antibacterial property of thyme essential oil due to different volatile compounds, has been well documented in the literature. To overcome the high volatility of essential oil components, encapsulation has emerged as a new alternative. In this work, chitosan and thyme essential oil-loaded chitosan nanoparticles (TEO-CSNPs) and nanocapsules (TEO-CSNCs) were prepared by nanoprecipitation and nanoencapsulation, respectively. The morphology, encapsulation efficiency, release kinetics, and inhibitory activity were evaluated...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28523490/ivermectin-lipid-based-nanocarriers-as-novel-formulations-against-head-lice
#3
Gabriela Ullio-Gamboa, Santiago Palma, Jean Pierre Benoit, Daniel Allemandi, María Inés Picollo, Ariel Ceferino Toloza
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability...
May 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28521992/tragacanth-nanocapsules-containing-chamomile-extract-prepared-through-sono-assisted-w-o-w-microemulsion-and-uv-cured-on-cotton-fabric
#4
Soraya Ghayempour, Majid Montazer
Encapsulation is the best method to protect the plant extracts against volatility and instability in the presence of air, light, moisture and high temperatures. Nevertheless, application of encapsulated plant extracts on the textiles requires a low-temperature and high rate processing to avoid from breaking or destroying of capsules. The present paper represents application of nanocapsules prepared by ultrasound irradiation assisted W/O/W microemulsion method on the cotton fabric through UV curing method. The surface and structure of nanocapsules and treated cotton fabric using FESEM and FT-IR indicated the spherical nanocapsules with size of 60-80nm stabilized on the fabric surface in a film layer feature...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28521578/improved-photostability-and-cytotoxic-effect-of-coenzyme-q10-by-its-association-with-vitamin-e-acetate-in-polymeric-nanocapsules
#5
Natháli S Pegoraro, Juliane Mattiazzi, Elita F da Silveira, Juliana H Azambuja, Elizandra Braganhol, Letícia Cruz
The present study showed the development of nanocapsules containing the association of the coenzyme Q10 and vitamin E acetate and the evaluation of their effect on in vitro cells culture of malignant glioma and melanoma. In order to investigate if nanocapsules are able to protect coenzyme Q10 from degradation under UVC radiation, a photostability study was carried out. For this, three concentrations of vitamin E acetate were evaluated (1, 2 or 3%). Nanocapsules presented suitable physicochemical characteristics and were able to protect coenzyme Q10 from photodegradation...
May 18, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28517963/novel-strategies-in-vaccine-design-can-nanocapsules-help-prevent-and-treat-hepatitis-b
#6
Stephan Gehring, Anette Pietrzak-Nguyen, Michael Fichter, Katharina Landfester
No abstract text is available yet for this article.
May 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28514833/antinociceptive-effect-of-%C3%AE-bisabolol-in-nanocapsules
#7
Gisele Façanha Diógenes Teixeira, Antonio Eufrásio Vieira-Neto, Flávio Nogueira da Costa, Angelo Roncalli Alves E Silva, Adriana Rolim Campos
This study aimed to develop and to evaluate the antinociceptive effect of a drug delivery system containing (-)-α-bisabolol (BISA). Nanocapsules containing BISA (BISA-NC) were prepared using acetylated galatomannan. Particle size distribution was determined by atomic force microscopy, zeta potential measurement and photon correlation spectroscopy. Corneal nociception was induced by topical application of 5M NaCl and the nociceptive behavior was characterized by eye wiping in mice. Molecular docking was conducted on the TRPV1 channel...
May 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28512018/nanoencapsulation-of-a-glucocorticoid-improves-barrier-function-and-anti-inflammatory-effect-on-monolayers-of-pulmonary-epithelial-cell-lines
#8
Lucas A Rigo, Cristiane S Carvalho-Wodarz, Adriana R Pohlmann, Silvia S Guterres, Nicole Schneider-Daum, Claus-Michael Lehr, Ruy C R Beck
The anti-inflammatory effect of polymeric deflazacort nanocapsules (NC-DFZ) was investigated, and possible improvement of epithelial barrier function using filter grown monolayers of A549 and Calu-3 using as models was assessed. NC prepared from poly(ε-caprolactone) (PCL) had a mean size around 200 nm, slightly negative zeta potential (∼ - 8 mV), and low polydispersity index (< 0.10). Encapsulation of DFZ had an efficiency of 85%. No cytotoxic effects were observed at particle concentration of 9.85 x 10(11) NC/ml, which was therefore chosen to evaluate the effect of NC-DFZ at 1% (w/v) of PCL and 0...
May 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28511536/biomimetic-silica-nanocapsules-for-tunable-sustained-release-and-cargo-protection
#9
Guang-Ze Yang, David Wibowo, Jung-Ho Yun, Lianzhou Wang, Anton Peter J Middelberg, Chun-Xia Zhao
Silica nanocapsules have attracted tremendous interest for encapsulation, protection and controlled release of various cargoes due to their unique hierarchical core-shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargo-protection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dual-templating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components...
May 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28510533/coordination-polymer-nanocapsules-prepared-using-metal-organic-framework-templates-for-ph-responsive-drug-delivery
#10
Tang Lei, Jiafu Shi, Xiaoli Wang, Shaohua Zhang, Hong Wu, Hongfan Sun, Zhongyi Jiang
A facile, efficient and versatile approach is presented to synthesize pH-responsive nanocapsules (~120 nm) by combining the advantages of metal-organic frameworks (MOFs) and metal-organic thin films. The ZIF-8 nanoparticles are used as templates on which a thin film coating of Iron(III)-catechol complexes is derived from the coordination between dopamine-modified alginate (AlgDA) and Iron(III) ions. After the templates removal, nanocapsules with a pH-responsive wall are obtained. Doxorubicin (Dox), a typical anticancer drug, is first immobilized in ZIF-8 frameworks through coprecipitation and then encapsulated in nanocapsules after the removal of ZIF-8...
May 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28499793/ciprofloxacin-loaded-lipid-core-nanocapsules-as-mucus-penetrating-drug-delivery-system-intended-for-the-treatment-of-bacterial-infections-in-cystic-fibrosis
#11
Afra Torge, Stefanie Wagner, Paula S Chaves, Edilene G Oliveira, Silvia S Guterres, Adriana R Pohlmann, Alexander Titz, Marc Schneider, Ruy C R Beck
Treatment of bacterial airway infections is essential for cystic fibrosis therapy. However, effectiveness of antibacterial treatment is limited as bacteria inside the mucus are protected from antibiotics and immune response. To overcome this biological barrier, ciprofloxacin was loaded into lipid-core nanocapsules (LNC) for high mucus permeability, sustained release, and antibacterial activity. Ciprofloxacin-loaded LNC with a mean size of 180nm showed a by 50% increased drug permeation through mucus. In antibacterial growth assays, the drug in the LNC had similar minimum inhibitory concentrations as the free drug in P...
May 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28499089/nanoencapsulation-of-aloe-vera-in-synthetic-and-naturally-occurring-polymers-by-electro-hydrodynamic-processing-of-interest-in-food-technology-and-bioactive-packaging
#12
Sergio Torres-Giner, Sabina Wilkanowicz, Beatriz Meléndez-Rodríguez, Jose M Lagaron
This work originally reports on the use of electro-hydrodynamic processing (EHDP) to encapsulate Aloe vera (AV) (Aloe barbadensis Miller) using both synthetic polymers, i.e. polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVOH), and naturally occurring polymers, i.e. barley starch (BS), whey protein concentrate (WPC) and maltodextrin. The AV leaf juice was used as the water-based solvent for EHDP and the resultant biopolymer solution properties were evaluated to determine their effect on the process. Morphological analysis revealed that, at the optimal processing conditions, synthetic polymers mainly produced fiber-like structures while naturally occurring polymers generated capsules...
May 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28496322/photoresponsive-nanocapsulation-of-cobra-neurotoxin-and-enhancement-of-its-central-analgesic-effects-under-red-light
#13
Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye
Cobra neurotoxin (CNT), a peptide isolated from snake venom of Naja naja atra, shows central analgesic effects in our previous research. In order to help CNT pass through blood-brain barrier (BBB) and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28488697/selective-c70-encapsulation-by-a-robust-octameric-nanospheroid-held-together-by-48-cooperative-hydrogen-bonds
#14
Grzegorz Markiewicz, Anna Jenczak, Michał Kołodziejski, Julian J Holstein, Jeremy K M Sanders, Artur R Stefankiewicz
Self-assembly of multiple building blocks via hydrogen bonds into well-defined nanoconstructs with selective binding function remains one of the foremost challenges in supramolecular chemistry. Here, we report the discovery of a enantiopure nanocapsule that is formed through the self-assembly of eight amino acid functionalised molecules in nonpolar solvents through 48 hydrogen bonds. The nanocapsule is remarkably robust, being stable at low and high temperatures, and in the presence of base, presumably due to the co-operative geometry of the hydrogen bonding motif...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28482541/liquid-formulation-containing-doxorubicin-loaded-lipid-core-nanocapsules-cytotoxicity-in-human-breast-cancer-cell-line-and-in-vitro-uptake-mechanism
#15
Michelli B Antonow, Ana Carolina C Asbahr, Paula Raddatz, Aline Beckenkamp, Andréia Buffon, Sílvia S Guterres, Adriana R Pohlmann
Cancer is a major public health problem in the world, being breast cancer the most frequent cancer affecting women. Despite advances in detection and treatment, mortality rates remain high. Therefore, new approaches for breast cancer treatments are necessary. In this study, our objective was to develop a liquid formulation containing doxorubicin-loaded lipid-core nanocapsules (DOX-LNC), to evaluate the in vitro antiproliferative activity and to determine the nanocapsules uptake by MCF-7 cells. Lipid-core nanocapsules (LNC), blank formulation, and DOX-LNC, proposed treatment, were prepared by self-assembling using the solvent displacement method...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482463/nanoencapsulation-of-lutein-and-its-effect-on-mice-s-declarative-memory
#16
Jéssica Thaís do Prado Silva, Júlia Maria Tonin Geiss, Sara Marchesan Oliveira, Evelyne da Silva Brum, Sara Cristina Sagae, Daniela Becker, Fernanda Vitória Leimann, Rafael Porto Ineu, Gustavo Petri Guerra, Odinei Hess Gonçalves
Lutein is a xanthophyll carotenoid widely known by its biological properties and low toxicity. When located in the brain, lutein may inhibit damage mechanisms, acting in neural cells maintenance. However, this carotenoid is very sensitive to external agents such as heat, light, pH and oxidation, besides presenting low absorption in gastrointestinal tract due its low solubility in water. Encapsulation procedures have shown promising results to increase lutein stability and bioavailability. In this work, lutein was encapsulated in polyvinylpyrrolidone (PVP) matrix by the dissolution in common solvent method...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28477394/a-spontaneous-structural-transition-of-u24pp12-clusters-triggered-by-alkali-counterion-replacement-in-dilute-solution
#17
Yunyi Gao, Mateusz Dembowski, Jennifer E S Szymanowski, Wenbin Yin, Steven S C Chuang, Peter C Burns, Tianbo Liu
A transition between two isomers involving the change of main skeleton structure of a well-defined, rigid molecular cluster [(UO2)24(O2)24(P2O7)12]48- (U24Pp12) is achieved by simply introducing proper alkali cations in its dilute aqueous solution. The two isomers, Li/Na-{U24Pp12} and Na/K-{U24Pp12}, as typical macroions, can accurately choose among different alkali countercations based on their hydrated sizes. The preferred K+ and Rb+ ions have suitable sizes to be incorporated into the proper windows on {U24Pp12} nanocapsules, leading to the unique structural transition, as supported by the thermodynamic results from the ITC studies and the gradual shift of the-yl oxygen peak from the IR measurements...
May 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28476970/synthesis-and-characterisation-of-peg-modified-chitosan-nanocapsules-loaded-with-thymoquinone
#18
Suresh Kumar Vignesh Kumar, Ponnuswamy Renuka Devi, Saru Harish, Eswaran Hemananthan
Thymoquinone (TQ), a major bioactive compound of Nigella sativa seeds has several therapeutic properties. The main drawback in bringing TQ to therapeutic application is that it has poor stability and bioavailability. Hence a suitable carrier is essential for TQ delivery. Recent studies indicate biodegradable polymers are potentially good carriers of bioactive compounds. In this study, polyethylene glycol (PEG) modified chitosan (Cs) nanocapsules were developed as a carrier for TQ. Aqueous soluble low molecular weight Cs and PEG was selected among different biodegradable polymers based on their biocompatibility and efficacy as a carrier...
February 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28465075/carbon-nanotube-capsules-enhance-the-in-vivo-efficacy-of-cisplatin
#19
Adem Guven, Gabriel J Villares, Susan G Hilsenbeck, Alaina Lewis, John D Landua, Lacey E Dobrolecki, Lon J Wilson, Michael T Lewis
Over the past few years, numerous nanotechnology-based drug delivery systems have been developed in an effort to maximize therapeutic effectiveness of conventional drug delivery, while limiting undesirable side effects. Among these, carbon nanotubes (CNTs) are of special interest as potential drug delivery agents due to their numerous unique and advantageous physical and chemical properties. Here, we show in vivo favorable biodistribution and enhanced therapeutic efficacy of cisplatin (CDDP) encapsulated within ultra-short single-walled carbon nanotube capsules (CDDP@US-tubes) using three different human breast cancer xenograft models...
April 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28463424/preparation-of-magnesium-seamed-c-alkylpyrogallol-4-arene-nanocapsules-with-varying-chain-lengths
#20
Chen Zhang, Rahul S Patil, Tao Li, Charles L Barnes, Simon J Teat, Jerry L Atwood
Novel supramolecular nanocapsules based on metal-directed assembly have captured tremendous interest due to their applications in fields such as catalysis, selective gas adsorption, and biomedicine. Functionalization of metal-organic nanocapusles (MONCs) by using organic ligands with different pendant groups affords more complexity to the structure and may lead to novel properties. In this work, we report the solvothermal synthesis of a group of magnesium-based metal-organic nanocapsules (MONCs) using C-alkylpyrogallol[4]arenes with varying alkyl chain lengths...
May 2, 2017: Chemistry: a European Journal
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