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Jiang-Lan Li, Ying-Jia Cheng, Chi Zhang, Han Cheng, Jun Feng, Ren-Xi Zhuo, Xuan Zeng, Xian-Zheng Zhang
To overcome drug resistance, efficient cancer therapeutic strategies using combination of small-molecule drugs and macromolecule drugs are highly desired. However, due to their significant differences in molecular weight and size, it is difficult to load them simultaneously in one vector and to release them individually. Here, a biodegradable organosilica based core/shell-structured nanocapsule was designed and used as a dual stimuli-responsive drug vector to solve this problem. Biodegradable organosilica shell coated outside the macromolecule model drug "core" would be disrupted by high glutathione (GSH) levels inside tumor cells, resulting in the escape of the entrapped drugs...
January 19, 2018: ACS Applied Materials & Interfaces
Mohd Anuar Mohd Firdaus, Annika Agatz, Mark E Hodson, Omar S A Al-Khazrajy, Alistair B A Boxall
Nanopesticides are novel plant protection products offering numerous benefits. As nanoparticles behave differently from dissolved chemicals, environmental risks of these materials could differ from conventional pesticides. Here we used soil-earthworm systems to compare the fate and uptake of analytical grade bifenthrin to that of bifenthrin in traditional and nano-encapsulated formulations. Apparent sorption coefficients for bifenthrin in the nano-treatments were up to 3.8 times lower than in the non-nano treatments whereas dissipation half-lives of the nano-treatments were up to two time longer...
January 17, 2018: Environmental Toxicology and Chemistry
Ling Wang, Yitong Wang, Shuli Dong, Yongming Deng, Jingcheng Hao
In order to endow valuable responsiveness to self-assemblies of Au nanoparticles, the magnetic Au nanoparticles (Au NPs)/CTACe mixtures were firstly prepared by using emulsion self-assembly of a magnetic surfactant, C16H33(CH3)3N+[CeCl3Br]-. A versatile of morphology of self-assemblies of Au NPs could be controlled by the counterions in surfactants including [CeCl3Br]-, [FeCl3Br]- and Br- as well as solvent. In particular, magnetic counterion, [CeCl3Br]-, can induce self-grown of Au NPs in emulsion self-assembly process due to the oxidability of [CeCl3Br]-...
January 17, 2018: ACS Applied Materials & Interfaces
Dongyuan Zhao, Tiancong Zhao, Peiyuan Wang, Qin Li, Areej Abdulkareem Al-Khalaf, Wael N Hozzein, Fan Zhang, Xiaomin Li
Nanoparticle based diagnosis-therapy integrative systems represent an emerging approach to cancer treatment. However, a series of size-dependent biological barriers impede nanomedicine from clinical implementation, especially the contradiction on optimum sizes for long blood circulation and quick metabolization. Herein, we demonstrate a novel NIR induced decomposable nanocapsule. The nanocapsules are fabricated based on layer-by-layer assembly of azobenzene functionalized polymers and up/downconversion nanoparticles (U/DCNPs)...
January 16, 2018: Angewandte Chemie
Flavien Sciortino, Gaulthier Rydzek, Fabien Grasset, Myrtil L Kahn, Jonathan P Hill, Soizic Chevance, Fabienne Gauffre, Katsuhiko Ariga
Hollow nanocapsules (named Hybridosomes®) possessing a polymer/nanoparticle shell were used to covalently construct hybrid films in a one-pot fashion. The alkyne bearing organic/inorganic Hybridosomes® were reticulated with azide bearing homobifunctional polyethyleneglycol (PEG) linkers, by using an electro-click reaction on F-SnO2 (FTO) electrodes. The coatings were obtained by promoting the Cu(i)-catalyzed click reaction between alkyne and azide moieties in the vicinity of the electrode by the electrochemical generation of Cu(i) ions...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
Cédric Colomban, Carles Fuertes-Espinosa, Sébastien Goeb, Marc Sallé, Miquel Costas, Lluís Blancafort, Xavi Ribas
Here we demonstrate the benefits of using cofacial Zn-porphyrins, used as structural synthons in coordination-driven self-assembled prisms, to produce cage-like singlet oxygen photosensitizers having tuneable photosensitizing properties. In particular, we describe the photosensitizing and emission properties of palladium and copper-based supramolecular capsules 1 and 2 and demonstrate that the nature of the bridging metal nodes in these discrete self-assembled prisms strongly influence the 1O2 generation at the Zn-porphyrin centers...
January 9, 2018: Chemistry: a European Journal
Catiúscia P de Oliveira, Sabrina L Büttenbender, Willian A Prado, Aline Beckenkamp, Ana C Asbahr, Andréia Buffon, Silvia S Guterres, Adriana R Pohlmann
Methotrexate is a folic acid antagonist and its incorporation into nanoformulations is a promising strategy to increase the drug antiproliferative effect on human breast cancer cells by overexpressing folate receptors. To evaluate the efficiency and selectivity of nanoformulations containing methotrexate and its diethyl ester derivative, using two mechanisms of drug incorporation (encapsulation and surface functionalization) in the in vitro cellular uptake and antiproliferative activity in non-tumoral immortalized human keratinocytes (HaCaT) and in human breast carcinoma cells (MCF-7)...
January 4, 2018: Nanomaterials
Chuang Gao, Xiaolong Liang, Shanyan Mo, Nisi Zhang, Desheng Sun, Zhifei Dai
A dual-in-dual synergistic strategy was proposed based on the self-assembly of combinatorial nanocapsules (NCs) from Janus camptothecin-floxuridine (CF) conjugate and near infrared absorber of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) by introducing PEGylated phospholipid of DSPE-PEG2000 to help NCs escape the rapid clearance from the bloodstream. Due to the use of amphiphilic CF and DiR themselves to form liposome-like nanocapsules, the obtained CF-DiR NCs owned significantly high loading content, stable co-delivery drug combinations, no premature release and excellent photothermal conversion efficiency...
January 4, 2018: ACS Applied Materials & Interfaces
Lu Yang, Wenfang Deng, Chang Cheng, Yueming Tan, Qingji Xie, Shouzhuo Yao
Herein, carbon dots (CDs)-encapsulated breakable organosilica nanocapsules (BONs) were facilely prepared and used as advanced fluorescent labels for ultrasensitive detection of Staphylococcus Aureus (S. Aureus). CDs were entrapped in organosilica shells by co-hydrolyzation of tetraethylorthosilicate and bis[3-(triethoxysilyl)propyl]disulfide to form core-shell CDs@BONs, where hundreds of CDs are encapsulated in each nanocapsule. Immunofluorescent nanocapsules, i.e. anti-S. Aureus antibody-conjugated CDs@BONs were prepared to specifically recognize S...
January 4, 2018: ACS Applied Materials & Interfaces
Chen Zhang, Kanishka Sikligar, Rahul S Patil, Charles L Barnes, Gary A Baker, Jerry L Atwood
We present here the preparation of a M18L6 hexameric metal-organic nanocapsule using a pyrogallol[3]resorcin[1]arene mixed macrocycle. The introduction of resorcinol moieties within the assembly leads to the formation of two open windows. This study demonstrates that introducing defects into the existing structure of nanocapsules may act as an effective method to tailor the composition and geometry, and introduce new properties.
January 4, 2018: Chemical Communications: Chem Comm
Hassan Nehme, Patrick Saulnier, Alyaa A Ramadan, Viviane Cassisa, Catherine Guillet, Matthieu Eveillard, Anita Umerska
Bacterial antibiotic resistance is an emerging public health problem worldwide; therefore, new therapeutic strategies are needed. Many studies have described antipsychotic compounds that present antibacterial activity. Hence, the aims of this study were to evaluate the in vitro antibacterial activity of antipsychotics belonging to different chemical families, to assess the influence of their association with lipid nanocapsules (LNCs) on their antimicrobial activity as well as drug release and to study the uptake of LNCs by bacterial cells...
2018: PloS One
Giuseppe Granata, Grazia M L Consoli, Raffaella Lo Nigro, Corrada Geraci
Ferulic, caffeic, sinapic, and coumaric acids, belonging to the class of hydroxycinnamic acids (HAs), are bioactive polyphenols widespread in the plant kingdom and present in the human diet. Due to their biological properties and effects in the prevention of various diseases associated with oxidative stress, HAs can be exploited for attractive nutraceutical applications. Starting from this and in order to increase bioaccessibility, we encapsulated HAs in lipid-core nanocapsules (NCs) based on a biodegradable and biocompatible poly(ε-caprolactone) polymer...
April 15, 2018: Food Chemistry
Zhaogang Teng, Chunyan Wang, Yuxia Tang, Wei Li, Lei Bao, Xuehua Zhang, Xiaodan Su, Fan Zhang, Junjie Zhang, Shouju Wang, Dongyuan Zhao, Guangming Lu
Mesoporous solids have been widely used in various biomedical areas such as drug delivery and tumor therapy. Although deformability has been recognized as a prime important characteristic influencing cellular uptake, the synthesis of deformable mesoporous solids is still a great challenge. Herein, deformable thioether-, benzene-, and ethane-bridged hollow periodic mesoporous organosilica (HPMO) nanocapsules have successfully been synthesized for the first time by a preferential etching approach. The prepared HPMO nanocapsules possess uniform diameters (240-310 nm), high surface areas (up to 878 m2g-1), well-defined mesopores (2...
December 27, 2017: Journal of the American Chemical Society
J Liu, L Lei, F Ye, Y Zhou, Heba G R Younis, G Zhao
Self-aggregates of octenylsuccinate oat β-glucan (AOSG) have been verified as nanocapsules to load curcumin, a representative of hydrophobic phytochemicals. This study primarily investigated the stability of curcumin-loaded AOSGs over food processing, storage and digestive fluids. Curcumin in AOSGs showed better stability over storage and thermal treatment than its free form. Curcumin loaded in AOSGs stored at 4 °C in the dark exhibited higher stability than that at higher temperatures or exposed to light...
December 15, 2017: Food & Function
Yining Xu, Dario Carradori, Mireille Alhouayek, Giulio G Muccioli, Patrice D Cani, Veronique Preat, Ana Beloqui
L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete physiologically important peptides. The most characterized peptides secreted by L cells are the peptide YY (PYY) and the glucagon-like peptide (GLP) -1 and -2. These peptides are released rapidly into the circulation after oral nutrient ingestion. Recently, lipid-based nanoparticles (NP) have been described as triggers for GLP-1 secretion by L cells. NP physicochemical properties play a key role in the NP-cell interaction, and drive NP cell internalization...
December 11, 2017: Molecular Pharmaceutics
Ana Carolina Moreira Souza, Vanessa Carla Furtado Mosqueira, Ana Paula Amariz Silveira, Lidiane Rodrigues Antunes, Sylvain Richard, Homero Nogueira Guimarães, Andrea Grabe-Guimarães
Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria. The purposes of this work were to study free-ATM and ATM-loaded poly-ε-caprolactone nanocapules (ATM-NC) cardiotoxicity and oral efficacy on Plasmodium berghei-infected mice. ATM-NC was obtained by interfacial polymer deposition and ATM was associated with polymeric NC oily core. For cardiotoxicity evaluation, male black C57BL6 uninfected or P. berghei-infected mice received, by oral route twice daily/4 days, vehicle (sorbitol/carboxymethylcellulose), blank-NC, free-ATM or ATM-NC at doses 40, 80 or 120 mg kg-1...
December 10, 2017: Parasitology
Zhijuan Sun, Chenxin Cai, Fei Guo, Changhuai Ye, Yingwu Luo, Shuming Ye, Jianchao Luo, Fan Zhu, Chunyue Jiang
Immobilization of the oxygen-sensitive probes (OSPs) in the host matrix greatly impacts the performance and long-term usage of the optical dissolved oxygen sensors. In this work, fluorescent dyes, as the OSPs, were encapsulated with a crosslinked fluorinated polymer shell by interfacial confined reversible addition fragmentation chain transfer miniemulsion polymerization to fabricate oxygen sensitive polymeric nanocapsules. The location of fluorescent dyes and the fluorescent properties of the nanocapsules were fully characterized by fourier transform infrared spectrometer(FTIR), X-ray photoelectron spectrometer(XPS) and fluorescent spectrum...
December 8, 2017: Nanotechnology
Dalila Moter Benvegnú, Katiane Roversi, Raquel Cristine Silva Barcelos, Fabíola Trevizol, Camila Simonetti Pase, Hecson Jesser Segat, Verônica Tironi Dias, Ana Luiza Savian, Bruna Lopes Piccoli, Jaqueline Piccolo, Carlos Severo Dutra-Filho, Tatiana Emanuelli, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Marilise Escobar Burger
Haloperidol is a widely used antipsychotic, despite the severe motor side effects associated with its chronic use. This study was carried out to compare oral dyskinesia induced by different formulations of haloperidol-loaded nanocapsules containing caprylic/capric triglycerides, fish oil or grape seed oil (GSO) as core, as well as free haloperidol. Haloperidol-loaded lipid-core nanocapsules formulations were prepared, physicochemical characterized and administered (0.5 mg kg-1-ip) to rats for 28 days. Oral dyskinesia was evaluated acutely and subchronically and after that cell viability and free radical generation in cortex and substantia nigra...
December 5, 2017: Neurochemical Research
Xue-Qing Huang, Hong-Ye Yang, Tao Luo, Cui Huang, Franklin R Tay, Li-Na Niu
Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility...
December 6, 2017: Acta Biomaterialia
Alejandro Valderrama, Radamés Reynoso, Raúl W Gómez, Manuel Quintana, Martín Romero
First principles calculations have been performed for C60@C180 carbon double-layer endofullerenes with up to: three diatomic radioiodine molecules (131I2), two potassium radio-iodide (K131I), and three sodium radio-iodide (Na131I) inside. The plane-wave pseudopotential (PP) method within the general gradient approximation (GGA) in the framework of the density functional theory (DFT) and time-dependent DFT (TD-DFT) was used to perform geometric optimizations (GOs) and molecular dynamics (MD) at 310 K and atmospheric pressure...
December 4, 2017: Journal of Molecular Modeling
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