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Annabelle Cikankowitz, Anne Clavreul, Clément Tétaud, Laurent Lemaire, Audrey Rousseau, Nicolas Lepareur, Djamel Dabli, Francis Bouchet, Emmanuel Garcion, Philippe Menei, Olivier Couturier, François Hindré
Internal radiation strategies hold great promise for glioblastoma (GB) therapy. We previously developed a nanovectorized radiotherapy that consists of lipid nanocapsules loaded with a lipophilic complex of Rhenium-188 (LNC(188)Re-SSS). This approach resulted in an 83 % cure rate in the 9L rat glioma model, showing great promise. The efficacy of LNC(188)Re-SSS treatment was optimized through the induction of a T-cell immune response in this model, as it is highly immunogenic. However, this is not representative of the human situation where T-cell suppression is usually encountered in GB patients...
October 25, 2016: Journal of Neuro-oncology
Nial J Wheate, Kristie-Ann Dickson, Ryung Rae Kim, Alireza Nematollahi, René B Macquart, Veysel Kayser, Guocan Yu, W Bret Church, Deborah J Marsh
Pillar[n]arenes are a new family of nanocapsules that have shown application in a number of areas, but because of their poor water solubility their biomedical applications are limited. Recently, a method of synthesizing water-soluble pillar[n]arenes was developed. In this study, carboxylated pillar[n]arenes (WP[n], n = 6 or 7) have been examined for their ability to form host-guest complexes with compounds relevant to drug delivery and biodiagnostic applications. Both pillar[n]arenes form host-guest complexes with memantine, chlorhexidine hydrochloride, and proflavine by (1)H nuclear magnetic resonance and modeling...
October 21, 2016: Journal of Pharmaceutical Sciences
Ming Ma, Fei Yan, Minghua Yao, Zijun Wei, Dongliang Zhou, Heliang Yao, Hairong Zheng, Hangrong Chen, Jianlin Shi
Entirely differing from the common templating-based multistep strategy in fabricating multifunctional hollow mesoporous silica nanoparticles (HMSNs), a facile and template-free synthetic strategy has been established in constructing a unique hollow/mesoporous organosilica nanocapsule concurrently encapsulating both isopentyl acetate (PEA) liquid and superparamagnetic iron oxides inside (denoted as PEA@OSNCs). This novel material exhibits ultrasmall and uniform particle size (~82 nm), high surface area (~534 m2 g-1) and excellent colloidal stability in aqueous solution...
October 24, 2016: ACS Applied Materials & Interfaces
Shuai Jiang, Beatriz Chiyin Ma, Jonas Reinholz, Qifeng Li, Junwei Wang, Kai A I Zhang, Katharina Landfester, Daniel Crespy
Materials with a hierarchical structure often demonstrate superior properties with combined and even synergistic effects of multiple functions. Herein, we report the design of a new class of material with a multicompartment nanofibrous structure as a promising candidate for antibacterial wound dressing and functional textile applications. The design consists in first synthesizing nanocapsules loaded with functional payloads and subsequently embedding the nanocapsules into polymer nanofibers by using colloid-electrospinning technique...
October 18, 2016: ACS Applied Materials & Interfaces
Seshasailam Venkateswaran, Orlando David Henrique Dos Santos, Emma Scholefield, Annamaria Lilienkampf, Peter J Gwynne, David G Swann, Kevin Dhaliwal, Maurice P Gallagher, Mark Bradley
Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating...
August 28, 2016: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Bo Tian, Qiuhong Wang, Qianqian Su, Wei Feng, Fuyou Li
Triplet-triplet annihilation (TTA)-based upconversion nanocapsules (UCNCs) have great potential in biological and medical applications. However, there are numerous unresolved issues with respect to the safety of these novel nanomaterials. In this work, for the first time, we studied the in vivo biodistribution of UCNCs which were synthesized by co-loading platinum (II)-tetraphenyl-tetrabenzoporphyrin (PtTPBP) and boron dipyrromethene derivative (BDP) into bovine serum albumin (BSA)-stabilized soybean oil droplets, and systematically assessed the potential toxicity of UCNCs both in vitro and in vivo...
October 8, 2016: Biomaterials
Rui Tang, Ziwen Jiang, Moumita Ray, Singyuk Hou, Vincent M Rotello
We report an effective intracellular delivery strategy for proteins of high molecular weight using AuNP stabilized capsules. This strategy provides direct delivery to the cytosol, avoiding endosomal entrapment.
October 14, 2016: Nanoscale
Wuxiao Ding, Masaru Aoyagi, Mitsutoshi Masuda, Masaki Kogiso
A novel lipid nanocapsule with high physical stability and the ability to undergo a water-responsive morphological change was prepared using a facile method from inexpensive and simple materials such as a glycylglycine-containing lipid and zinc acetate. The zinc-coordinated nanocapsule is comprised of solid bilayer membranes, which are stabilized by polyglycine-II type hydrogen-bond network and Zn-lipid coordination resulting in a high thermal stability in the dry state. The nanocapsules can easily encapsulate guest molecules such as methylene blue in the hollow space by dissolving the molecules in ethanol during preparation...
October 12, 2016: Journal of Oleo Science
Stefanie U Frick, Matthias P Domogalla, Grit Baier, Frederik R Wurm, Volker Mailaender, Katharina Landfester, Kerstin Steinbrink
A major demand on immunotherapy is the direct interference with specific immune cells in vivo. In contrast to antibody-engineered nanoparticles to control dendritic cells function, targeting of T cells for biomedical applications still remains an obstacle as they disclose reduced endocytic activities. Here, by coupling the cytokine interleukin-2 (IL-2) to the surface of hydroxyethyl starch nanocapsules we demonstrated a direct and specifc T cell targeting in vitro and in vivo by IL-2 receptor mediated internalization...
October 10, 2016: ACS Nano
Lungile Nomcebo Thwala, Ana Beloqui, Noemi Stefania Csaba, David González-Touceda, Sulay Tovar, Carlos Dieguez, Maria Jose Alonso, Véronique Préat
Single-layer protamine and double layer polysialic acid (PSA)/protamine nanocapsules (NCs) were designed in order to be used as carriers to facilitate the transport of macromolecules across the intestinal epithelium. The rational for the design of these NCs was based on that protamine is a non-toxic yet potent cell-penetrating peptide, capable of translocating protein cargos through cell membranes, while PSA is a low molecular weight polysaccharide used to enhance the stability of macromolecules and nanocarriers...
October 6, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
He Feng, Lei Wang, Lu Zhao, Chungui Tian, Peng Yu, Honggang Fu
The exploration of low-cost and highly efficient non-platinum electrocatalysts for the oxygen reduction reaction (ORR) is vital for renewable systems. Herein, we report a novel non-platinum electrocatalyst consisting of B and N separately co-doped graphitic carbon encapsulated Fe/Fe3C nanoparticles (BNGFe), which were synthesized from a facile method by adopting melamine, iron nitrate and boric acid as the precursors. In this synthesis, the N atoms in melamine first bond with the iron ions in iron nitrate, which could prevent the formation of BN covalent bonds during the subsequent pyrolysed process, resulting in the formation of effective B and N separately co-doped graphitic carbon encapsulated on the Fe/Fe3C nanoparticles...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
Laura De Matteis, Maria Alleva, Inés Serrano-Sevilla, Sonia García-Embid, Grazyna Stepien, María Moros, Jesús M de la Fuente
The tunability of the properties of chitosan-based carriers opens new ways for the application of drugs with low water-stability or high adverse effects. In this work, the combination of a nanoemulsion with a chitosan hydrogel coating and the following poly (ethylene glycol) (PEG) grafting is proven to be a promising strategy to obtain a flexible and versatile nanocarrier with an improved stability. Thanks to chitosan amino groups, a new easy and reproducible method to obtain nanocapsule grafting with PEG has been developed in this work, allowing a very good control and tunability of the properties of nanocapsule surface...
September 30, 2016: Marine Drugs
Soraya Ghayempour, Majid Montazer
Herbal products have been widely used due to good antimicrobial, fragrance and medical properties. Essential oils and fragrances can be applied on the textile substrates as micro/nanocapsules to prolong lifetime by controlling the release rate. The present review tries to give a general overview on the application of micro/nanoencapsulated essential oils on the textile substrates to achieve aromatherapy textiles. These are divided into four diverse categories as the following: antimicrobial, perfumed, mosquito-repellent and medical textiles...
October 4, 2016: Journal of Microencapsulation
Jinxie Zhang, Xudong Zhang, Gan Liu, Danfeng Chang, Xin Liang, Xianbing Zhu, Wei Tao, Lin Mei
The inner membrane vesicle system is a complex transport system that includes endocytosis, exocytosis and autophagy. However, the details of the intracellular trafficking pathway of nanoparticles in cells have been poorly investigated. Here, we investigate in detail the intracellular trafficking pathway of protein nanocapsules using more than 30 Rab proteins as markers of multiple trafficking vesicles in endocytosis, exocytosis and autophagy. We observed that FITC-labeled protein nanoparticles were internalized by the cells mainly through Arf6-dependent endocytosis and Rab34-mediated micropinocytosis...
2016: Theranostics
Fernando Rodríguez-Serrano, Nuria Mut-Salud, Teresa Cruz-Bustos, Mercedes Gomez-Samblas, Esther Carrasco, Jose Manuel Garrido, F Javier López-Jaramillo, Francisco Santoyo-Gonzalez, Antonio Osuna
BACKGROUND: Around 20%-30% of breast cancers overexpress the proto-oncogene human epidermal growth receptor 2 (HER2), and they are characterized by being very invasive. Therefore, many current studies are focused on testing new therapies against tumors that overexpress this receptor. In particular, there exists major interest in new strategies to fight breast cancer resistant to trastuzumab (Tmab), a humanized antibody that binds specifically to HER2 interfering with its mitogenic signaling...
2016: International Journal of Nanomedicine
Benonio T Villalba, Francine R Ianiski, Ane G Vogt, Mikaela P Pinz, Angélica S Reis, Rodrigo A Vaucher, Mauro P Soares, Ethel A Wilhelm, Cristiane Luchese
This study determined whether meloxicam in nanocapsules modifies stomach and liver damage caused by free meloxicam in mice. Male Swiss mice were treated with blank nanocapsules or meloxicam in nanocapsules or free meloxicam (10 mg/kg, intragastrically, daily for five days). On the seventh day, blood was collected to determine biochemical markers (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, total bilirubin, unconjugated bilirubin, albumin and alkaline phosphatase). Stomachs and livers were removed for histological analysis...
September 21, 2016: Regulatory Toxicology and Pharmacology: RTP
Michael Fichter, Keti Piradashvili, Anette Pietrzak-Nguyen, Leah Pretsch, Gabor Kuhn, Susanne Strand, Markus Knuf, Fred Zepp, Frederik R Wurm, Volker Mailänder, Katharina Landfester, Stephan Gehring
Targeting antigen combined with adjuvants to hepatic antigen-presenting cells (APCs) is essential for the induction of intrahepatic T cellular immunity controlling and resolving viral infections of the liver. Intravenous injection of antigen-loaded nanoparticles is a promising approach for the delivery of antigens to liver APCs. Accordingly, polymeric nanocapsules (NCs) synthesized exclusively of hepatitis C virus non-structural protein 5A (NS5A) and the adjuvant monophosphoryl lipid A (MPLA) adsorbed to the nanocapsule surface were developed...
November 2016: Biomaterials
Arunkumar Ranganathan, Ravi Hindupur, Baskaran Vallikannan
Lutein-poly-(lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared (henceforth referred as lutein nanocapsules) and studied for acute, subacute oral toxicity and bioavailability of lutein in mice. Prior to examining the safety of lutein nanocapsules, particle size, zeta potential, surface morphology and interaction between lutein, PLGA and PL were studied. In acute study, mice were gavaged with a single dose of lutein nanocapsules at 0.1, 1, 10 and 100mg/kg body weight (BW) and examined for 2weeks, while in subacute study, daily mice were gavaged with a dose of 1 and 10mg/kg BW for 4weeks...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Enza Torino, Rosaria Aruta, Teresa Sibillano, Cinzia Giannini, Paolo A Netti
Phase separation of a polymer solution exhibits a peculiar behavior when induced in a nanoconfinement. The energetic constraints introduce additional interactions between the polymer segments that reduce the number of available configurations. In our work, this effect is exploited in a one-step strategy called nanoconfined-Thermally Induced Phase Separation (nc-TIPS) to promote the crystallization of polymer chains into nanocapsular structures of controlled size and shell thickness. This is accomplished by performing a quench step of a low-concentrated PLLA-dioxane-water solution included in emulsions of mean droplet size <500 nm acting as nanodomains...
2016: Scientific Reports
Md Habban Akhter, Saima Amin
Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination therapy is always preferred than single treatment modality due to poor internalization of most of the chemotherapeutics in the affected cells. Now a days, nanoparticle based drug delivery to squamous cell carcinoma is equanimous to become a leading therapeutic approach for cancer treatment...
September 6, 2016: Current Drug Delivery
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