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Nanocapsule

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https://www.readbyqxmd.com/read/29778890/dual-photoacoustic-ultrasound-multi-parametric-imaging-from-passion-fruit-like-nano-architectures
#1
Paolo Armanetti, Salvador Pocoví-Martínez, Alessandra Flori, Cinzia Avigo, Domenico Cassano, Luca Menichetti, Valerio Voliani
Ultrasound (US) imaging is a well-established diagnostic technique to image soft tissues in real time, while photoacoustic (PA) is an emerging imaging technique employed to collect molecular information. Integration of PA and US imaging provides complementary information enhancing diagnostic accuracy without employing ionizing radiations. The development of contrast agents able to combine PA and US features is pivotal to improve the significance of PAUS imaging and for PAUS-guided treatment of neoplasms. Here, we demonstrate in relevant ex-vivo models that disassembling passion fruit-like nano-architectures (pfNAs) can be employed in PAUS imaging...
May 17, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29778782/acyclovir-lipid-nanocapsules-gel-for-oromucosal-delivery-a-preclinical-evidence-of-efficacy-in-the-chicken-pouch-membrane-model
#2
Darine Abozaid, Alyaa Ramadan, Heba Barakat, Nawal Khalafallah
The study aimed to develop a patient-friendly acyclovir gel with improved efficacy in viral mouth infections, in response to patients' need for an intraoral acyclovir product. Acyclovir was loaded in lipid nanocapsules in gel form, and formulae were evaluated for oromucosal delivery. Lipid nanocapsules were prepared by the phase inversion method. Formulae were optimized to achieve maximum acyclovir entrapment and minimum acyclovir precipitation. Colloidal properties, and pharmaceutical performance indicators were assessed...
May 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29771175/tamoxifen-citrate-loaded-chitosan-gellan-nanocapsules-for-breast-cancer-therapy-development-characterisation-and-in-vitro-cell-viability-study
#3
Pankaj Kumar Kathle, Nivedita Gautam, Karthikeyan Kesavan
The objective of this study was to evaluate the potential of Chitosan-Gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen Citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by FT-IR, DSC and XRD to investigate any interaction between drug and excipients. Physicochemical parameters, in vitro drug release and release kinetic were studied. In vitro cell viability study using Michigan Cancer Foundation-7 (MCF-7) breast cancer cells was also investigated...
May 17, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29768877/decoration-of-a-poly-methyl-vinyl-ether-co-maleic-anhydride-shelled-selol-nanocapsule-with-folic-acid-increases-its-activity-against-different-cancer-cell-lines-in-vitro
#4
Rayane Ganassin, Ludmilla Regina de Souza, Karen Rapp Py-Daniel, João Paulo Figueiró Longo, Janaína Moreira Coelho, Mosar Correa Rodrigues, Cheng-Shi Jiang, Jinsong Gu, Paulo César de Morais, Ewa Mosiniewicz-Szablewska, Piotr Suchocki, Sônia Nair Báo, Ricardo Bentes Azevedo, Luis Alexandre Muehlmann
Due to the low therapeutic index of different chemotherapeutic drugs used for cancer treatment, the development of new anticancer drugs remains an intense field of research. A recently developed mixture of selenitetriacylglycerides, selol, was shown to be active against different cancer cells in vitro. As this compound is highly hydrophobic, it was encapsulated, in a previous study, into poly(methyl vinyl ether-co-maleic anhydride)-shelled nanocapsules in order to improve its dispersibility in aqueous media...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29765045/hybrid-nanostructured-particles-via-surfactant-free-double-miniemulsion-polymerization
#5
Yongliang Zhao, Junli Liu, Zhi Chen, Xiaomin Zhu, Martin Möller
Double emulsions are complex fluid systems, in which droplets of a dispersed liquid phase contain even smaller dispersed liquid droplets. Particularly, water-in-oil-in-water double emulsions provide significant advantages over simple oil-in-water emulsions for microencapsulation, such as carrier of both aqueous and oily payloads and sustained release profile. However, double emulsions are thermodynamically unstable systems consisting typically of relatively large droplets. Here we show that nanoscale water-in-oil-in-water double emulsions can be prepared by adding a silica precursor polymer, hyperbranched polyethoxysiloxane, to the oil phase without any additional surfactants...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29762622/charge-switchable-nanocapsules-with-multistage-ph-responsive-behaviours-for-enhanced-tumour-targeted-chemo-photodynamic-therapy-guided-by-nir-mr-imaging
#6
Jia Zhou, Tianliang Li, Chunlei Zhang, Junyuan Xiao, Daxiang Cui, Yingsheng Cheng
Multifunctional nanoplatforms have been developed into advanced drug delivery systems for cancer therapy. In this study, we report a charge-switchable nanocapsule with multistage pH-responsive behaviors. First, DOX-encapsulated and oleylamine-embedded hollow structures with a diameter of 132 ± 21 nm are prepared via the double emulsion method. Subsequently, the hollow structures are encompassed by Gd-DTPA-, chlorin e6 (Ce6)-, and folate (FA)-modified BSA to form tumour-targeted, dual NIR/MR imaging-guided and chemo-photodynamic therapeutic nanoplatforms...
May 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29734007/collagenase-nanocapsules-an-approach-to-fibrosis-treatment
#7
María Rocío Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L Pablos, María Vallet-Regí
Fibrosis is a common lesion in different pathologic diseases and defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. The FDA and EMA approved the use of collagenase to treat palmar fibromatosis (Dupuytren's contracture). The EMA approved additionally its use in severe Peyronie's disease, but it has been used off label in other conditions.[1,2] The approved treatment includes up to three (in palmar fibromatosis) or up to eight (in penile fibromatosis) injections followed by finger extension or penile modeling procedures, typically causing severe pain...
May 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29732888/nanoencapsulation-of-cyanidin-3-o-glucoside-enhances-protection-against-uvb-induced-epidermal-damage-through-regulation-of-p53-mediated-apoptosis-in-mice
#8
Zhaohan Liu, Yunfeng Hu, Xia Li, Zhouxiong Mei, Shi Wu, Yong He, Xinwei Jiang, Jianxia Sun, Jianbo Xiao, Liehua Deng, Weibin Bai
Excess ultraviolet (UV) radiation causes numerous forms of skin damage. The aim of the present study was to assess and compare the photoprotective effects of cyanidin-3-O-glucoside (C3G) alone and encapsulated in chitosan nanoparticles (Nano-C3G) in a UVB-induced acute photodamage mouse model. Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation. The particle size, zeta potential, entrapment efficiency, drug loading, and in vitro release in 6 days were determined. Kunming (KM) mice were treated with Nano-C3G (125, 250, 500 µM) or C3G (500 µM) after part of the dorsal skin area was dehaired, and then exposed to 2 J/cm2 of UVB...
May 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29725329/polymeric-nanocapsules-for-vaccine-delivery-influence-of-the-polymeric-shell-on-the-interaction-with-the-immune-system
#9
Mercedes Peleteiro, Elena Presas, Jose Vicente González-Aramundiz, Beatriz Sánchez-Correa, Rosana Simón-Vázquez, Noemi Csaba, María J Alonso, África González-Fernández
The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions between these systems and immunocompetent cells, we describe here a systematic in vitro and in vivo study on three types of polymeric nanocapsules (NCs). These carriers, which contained protamine (PR), polyarginine (PARG), or chitosan (CS) in the external shell, and their corresponding nanoemulsion were prepared, and their main physicochemical properties were characterized...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29722520/microbubble-triggered-spontaneous-separation-of-transparent-thin-films-from-substrates-using-evaporable-core-shell-nanocapsules
#10
Intae Son, Byungsun Lee, Jae Hong Kim, Chunho Kim, Ji Yong Yoo, Byung Wook Ahn, Jeongho Hwang, Jonghyuk Lee, Jun Hyup Lee
The spontaneous separation of a polymer thin film from a substrate is an innovative technology that will enable material recycling and reduce manufacturing cost in the film industry, and this can be applied in a wide range of applications, from optical films to wearable devices. Here, we present an unprecedented spontaneous strategy for separating transparent polymer films from substrates on the basis of micro-bubble generation using nanocapsules containing an evaporable material. The core-shell nanocapsules are prepared from poly(methyl methacrylate)-polyethyleneimine nanoparticles via the encapsulation of methylcyclohexane (MCH)...
May 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29713034/dynamic-actuation-of-glassy-polymersomes-through-isomerization-of-a-single-azobenzene-unit-at-the-block-copolymer-interface
#11
Mijanur Rahaman Molla, Poornima Rangadurai, Lucas Antony, Subramani Swaminathan, Juan J de Pablo, S Thayumanavan
Nature has engineered exquisitely responsive systems where molecular-scale information is transferred across an interface and propagated over long length scales. Such systems rely on multiple interacting, signalling and adaptable molecular and supramolecular networks that are built on dynamic, non-equilibrium structures. Comparable synthetic systems are still in their infancy. Here, we demonstrate that the light-induced actuation of a molecularly thin interfacial layer, assembled from a hydrophilic- azobenzene -hydrophobic diblock copolymer, can result in a reversible, long-lived perturbation of a robust glassy membrane across a range of over 500 chemical bonds...
April 30, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29692974/lipid-nanocapsules-formulation-and-cellular-activities-evaluation-of-a-promising-anticancer-agent-eapb0503
#12
Adrien Chouchou, Anne Aubert-Pouëssel, Christophe Dorandeu, Zahraa Zghaib, Pierre Cuq, Jean-Marie Devoisselle, Pierre-Antoine Bonnet, Sylvie Bégu, Carine Deleuze-Masquefa
Objective: EAPB0503, lead compound of imiqualines, presented high antitumor activities but also a very low water solubility which was critical for further preclinical studies. To apply to EAPB0503, a robust and safe lipid formulation already used for poor soluble anticancer agents for injectable administration at a concentration higher than 1 mg/mL. Materials and Methods: Physicochemical properties of EAPB0503 were determined to consider an adapted formulation. In a second time, lipid nanocapsules (LNC) formulations based on the phase-inversion process were developed for EAPB0503 encapsulation...
October 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29687130/size-dependent-endocytosis-and-a-dynamic-release-model-of-nanoparticles
#13
Ruihao Pan, Guoqiang Liu, Yongsan Li, Yen Wei, Shurun Li, Lei Tao
Polymeric nanoparticles for drug delivery are attracting broad interest along with the rapid development of biomedical and healthcare research. Here, we prepared a series of nanocapsules via electrostatic precipitation of chitosan and lecithin micelles. These nanocapsules have controlled diameters (∼25-200 nm) that only slightly changed after several lyophilization-dissolving cycles, suggesting their excellent stability for long-term storage. In cell experiments, these nanocapsules obviously reduced the cytotoxicity of encapsulated small molecules, and clearly showed size-dependent endocytosis...
April 24, 2018: Nanoscale
https://www.readbyqxmd.com/read/29679292/preparation-and-optimization-lipid-nanocapsules-to-enhance-the-antitumor-efficacy-of-cisplatin-in-hepatocellular-carcinoma-hepg2-cells
#14
Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang
This work aimed to develop and optimize several lipid nanocapsule formulations (LNCs) to encapsulate cisplatin (CDDP) for treatment of hepatocellular carcinoma. By comparing the effect of oil/surfactant ratio, lecithin content, and oil/surfactant type on LNC characteristics, two LNCs were selected as optimal formulations: HS15-LNC (Solutol HS 15/MCT/lecithin, 54.5:42.5:3%, w/w) and EL-LNC (Cremophor EL/MCT/lecithin, 54.5:42.5:3%, w/w). Both LNCs could effectively encapsulate CDDP with the encapsulation efficiency of 73...
April 20, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29677755/evaluation-of-color-and-structure-of-%C3%AE-fe%C3%A2-o%C3%A2-nanocapsules-by-tuning-of-the-sio%C3%A2-morphology
#15
Ri Yu, Gye Seok An, Jae-Hwan Pee, YooJin Kim
In this study, we synthesized a core/yolk-shell α-Fe2O3@SiO2 structure by treatment of SiO2 shell with mild basic solution. Spindle shaped α-Fe2O3 nanoparticles were initially prepared as core materials and subsequently coated with silica via sol-gel method. The yolk shell of α-Fe2O3 was produced by dissolution of silica shell from core-shell type hematite in NH4OH solution. In addition, the correlation between the density and morphology of the silica coating layer and the chromaticity according to the NH4OH concentration and the etching time was confirmed...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29673839/development-of-a-macrophage-targeting-and-phagocytosis-inducing-bio-nanocapsule-based-nanocarrier-for-drug-delivery
#16
Hao Li, Kenji Tatematsu, Masaharu Somiya, Masumi Iijima, Shun' Ichi Kuroda
Macrophage hyperfunction or dysfunction is tightly associated with various diseases, such as osteoporosis, inflammatory disorder, and cancers. However, nearly all conventional drug delivery system (DDS) nanocarriers utilize endocytosis for entering target cells; thus, the development of macrophage-targeting and phagocytosis-inducing DDS nanocarriers for treating these diseases is required. In this study, we developed a hepatitis B virus (HBV) envelope L particle (i.e., bio-nanocapsule (BNC)) outwardly displaying a tandem form of protein G-derived IgG Fc-binding domain and protein L-derived IgG Fab-binding domain (GL-BNC)...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29667445/the-mechanism-of-lauric-acid-modified-protein-nanocapsules-escape-from-intercellular-trafficking-vesicles-and-its-implication-for-drug-delivery
#17
Lijuan Jiang, Xin Liang, Gan Liu, Yun Zhou, Xinyu Ye, Xiuli Chen, Qianwei Miao, Li Gao, Xudong Zhang, Lin Mei
Protein nanocapsules have exhibited promising potential applications in the field of protein drug delivery. A major issue with various promising nano-sized biotherapeutics including protein nanocapsules is that owing to their particle size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. In addition, many nano-sized biotherapeutics could be also sequestered by autophagosomes and degraded through the autolysosomal pathway...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#18
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664280/reductive-responsive-single-molecular-layer-polymer-nanocapsules-prepared-by-lateral-functionalized-pillar-5-arenes-for-targeting-anticancer-drug-delivery
#19
Shuang Fu, Yue Zhang, Qiaoxian Huang, Shuwen Guan, Ruibing Wang, Mingsong Zang, Ruizhen Tian, Shanpeng Qiao, Xin Zhang, Shengda Liu, Xiaotong Fan, Xiumei Li, Quan Luo, Chunxi Hou, Jiayun Xu, Zeyuan Dong, Junqiu Liu
Herein, a new reductive-responsive pillar[5]arene-based single-molecule layer polymer nanocapsules are constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery, but also extends the design of smart materials for biomedical applications...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29664104/self-assembled-nanodiamond-supraparticles-for-anticancer-chemotherapy
#20
Yue Yu, Masahiro Nishikawa, Ming Liu, Takahiro Tei, Sunil C Kaul, Renu Wadhawa, Minfang Zhang, Junko Takahashi, Eijiro Miyako
A nanodiamond (ND) is a promising material for drug delivery applications owing to its relatively low cost, amenability to large-scale synthesis, unique structure, and low toxicity. However, synthesizing drug-loaded ND conjugates with uniform and tunable sizes, high loading capacity, efficacy in drug delivery, and versatility in terms of surface functionalization has been challenging. Here, we show that perfluorooctanoic acid-functionalized NDs spontaneously transform into well-dispersed and biocompatible supraparticle (SP) nanoclusters...
April 17, 2018: Nanoscale
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