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https://www.readbyqxmd.com/read/28732861/fabrication-and-characterization-of-hollow-starch-nanoparticles-by-gelation-process-for-drug-delivery-application
#1
Jie Yang, Fang Li, Man Li, Shuangling Zhang, Jing Liu, Caifeng Liang, Qingjie Sun, Liu Xiong
Hollow nanoparticles (HNPs) have been widely regarded as controlled drug carriers owing to their advantages, such as high drug-loading efficiency and superior control over drug delivery and release. In this study, a facile and efficient strategy has been exploited for preparation of hollow starch nanoparticles (HSNPs) via a sacrificial hard-template process using gelled starch as the shell. These nanocapsules have been characterized through various techniques, including transmission electron microscopy, differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectroscopy...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28724950/nanocapsules-containing-neem-azadirachta-indica-oil-development-characterization-and-toxicity-evaluation
#2
Tatiane Pasquoto-Stigliani, Estefânia V R Campos, Jhones L Oliveira, Camila M G Silva, Natalia Bilesky-José, Mariana Guilger, Johann Troost, Halley C Oliveira, Renata Stolf-Moreira, Leonardo F Fraceto, Renata de Lima
In this study, we prepared, characterized, and performed toxicity analyses of poly(ε-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The nanocapsules showed a mean size distribution around 400 nm, with polydispersity below 0.2 and were stable for 120 days. Cytotoxicity and genotoxicity results showed an increase in toxicity of the oleic acid + neem formulations according to the amount of oleic acid used. The minimum inhibitory concentrations demonstrated that all the formulations containing neem oil were active...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723214/electrokinetic-manipulation-integrated-plasmonic-photonic-hybrid-raman-nanosensors-with-dually-enhanced-sensitivity
#3
Chao Liu, Zheng Wang, Erwen Li, Zexi Liang, Swapnajit Chakravarty, Xiaochuan Xu, Alan X Wang, Ray T Chen, Donglei Fan
To detect biochemicals with ultrahigh sensitivity, efficiency, reproducibility, and specificity has been the holy grail in the development of nanosensors. In this work, we report an innovative type of photonic-plasmonic hybrid Raman nanosensor integrated with electrokinetic manipulation by rational design, which offers dual mechanisms that enhance the sensitivity for molecule detection directly in solution. For the first time, we integrate large arrays of synthesized plasmonic nanocapsules with densely surface distributed silver (Ag) nanoparticles (NPs) on lithographically patterned photonic crystal slabs via electric-field assembling...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#4
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28715200/unraveling-the-single-nanometer-thickness-of-shells-of-vesicle-templated-polymer-nanocapsules
#5
Andrew George Richter, Sergey A Dergunov, Mariya D Kim, Sergey N Shmakov, Sai Venkatesh Pingali, Volker S Urban, Yun Liu, Eugene Pinkhassik
The recent emergence of vesicle-templated nanocapsules as a viable platform for diverse applications has heightened the need for detailed structural characterization of nanocapsule shells and for better understanding of surfactant-mediated directed assembly of nanomaterials. Information on the thickness is a critical structural parameter of nanocapsules, where the shell plays a crucial role providing mechanical stability and control of permeability. Here we used small-angle neutron scattering (SANS) to determine the thickness of freestanding and surfactant-stabilized nanocapsules...
July 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28715021/graphitic-nanocapsules-design-synthesis-and-bioanalytical-applications
#6
REVIEW
Ding Ding, Yiting Xu, Yuxiu Zou, Long Chen, Zhuo Chen, Weihong Tan
Graphitic nanocapsules are emerging nanomaterials which are gaining popularity along with the development of carbon nanomaterials. Their unique physical and chemical properties, as well as good biocompatibility, make them desirable agents for biomedical and bioanalytical applications. Through rational design, integrating graphitic nanocapsules with other materials provides them with additional properties which make them versatile nanoplatforms for bioanalysis. In this feature article, we present the use and performance of graphitic nanocapsules in a variety of bioanalytical applications...
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28688395/assessing-the-accuracy-of-integral-equation-theories-for-nano-sized-hydrophobic-solutes-in-water
#7
Takatoshi Fujita, Takeshi Yamamoto
Integral equation theories provide an efficient route for computing the solvation free energy (SFE) of molecular systems in water. The accuracy of those theories is usually tested against small molecules via comparison of SFE with reference data. However, tests against larger molecules in the nanometer regime are scarce in literature despite recent applications to such systems. Here, we thus study the accuracy and validity of a commonly used integral equation theory, namely, a three-dimensional reference interaction site model (3D-RISM), by considering the following problems: (1) solvation of a small to large Lennard-Jones particle, (2) binding of planar hydrophobic systems with varying size and hydrophobicity, and (3) self-assembly of amphiphilic molecules into a nanocapsule...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28684908/%C3%AE-bisabolol-loaded-lipid-core-nanocapsules-reduce-lipopolysaccharide-induced-pulmonary-inflammation-in-mice
#8
Ana Paula L D'Almeida, Maria T Pacheco de Oliveira, Éverton T de Souza, Diego de Sá Coutinho, Bianca T Ciambarella, Cristiano R Gomes, Thatiana Terroso, Sílvia S Guterres, Adriana R Pohlmann, Patrícia Mr Silva, Marco A Martins, Andressa Bernardi
Acute respiratory distress syndrome (ARDS) is a severe clinical condition of respiratory failure due to an intense inflammatory response with different etiologies. Despite all efforts, therapy remains limited, and ARDS is still associated with high mortality and morbidity. Plants can provide a vast source of active natural products for the discovery of new drugs. α-bisabolol (α-bis), a constituent of the essential oil from chamomile, has elicited pharmacological interest. However, the molecule has some limitations to its biological application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28684364/polyarginine-nanocapsules-a-versatile-nanocarrier-with-potential-in-transmucosal-drug-delivery
#9
Ana Gonzalez-Paredes, Dolores Torres, María José Alonso
The objective of this work was to investigate the potential utility of nanocapsules composed of an oily core decorated with a single polyarginine (PARG), or double PARG/polyacrylic acid (PAA) layer as oral peptide delivery carrier. A step-by-step formulation optimization process was designed, which involved the study of the influence of the surfactants, oils and polymer shells (PARG of different molecular weight and PAA) on the nanocapsules physicochemical properties, peptide loading efficiency, stability in simulated intestinal fluids (SIF) and capacity to enhance the permeability of the intestinal epithelium...
July 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28681900/tile-based-self-assembly-of-a-triple-helical-polysaccharide-into-cell-wall-like-mesoporous-nanocapsules
#10
Chaoxi Wu, Xiaoying Wang, Jianjing Wang, Zhen Zhang, Zhiping Wang, Yifei Wang, Shunqing Tang
Tile-based self-assembly is a robust system in the construction of three-dimensional DNA nanostructures but it has been rarely applied to other helical biopolymers. β-Glucan is an immunoactive natural polymer which exists in a triple helical conformation. Herein, we report that β-glucan, after modification using two types of short chain acyl groups, can self-assemble into tiles with inactivated sticky ends at the interface of two solvents. These tiles consist of a single layer of helices laterally aligned, and the sticky ends can be activated when a few acyl groups at the ends are removed; these tiles can further pack into mesoporous nanocapsules, in a similar process as the sticky DNA tiles pack into complex polyhedral nano-objects...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28679052/controlling-encapsulation-of-charged-molecules-in-vesicle-templated-nanocontainers-through-electrostatic-interactions-with-the-bilayer-scaffold
#11
Mariya D Kim, Sergey A Dergunov, Eugene Pinkhassik
This work addresses the challenge of creating hollow nanocapsules with controlled amount of encapsulated molecules. Such nanocontainers or nanorattle-like structures represent an attractive platform for building functional devices, including nanoreactors and nano sensors. By taking advantage of electrostatic attraction between oppositely charged cargo molecules and the surface of templating bilayer of catanionic vesicles, formed by mixing single-tailed cationic and anionic surfactants, we were able to achieve substantial increase of the local concentration of molecules inside the vesicle-templated nanocapsules...
July 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28678551/nano-encapsulated-metformin-curcumin-in-plga-peg-inhibits-synergistically-growth-and-htert-gene-expression-in-human-breast-cancer-cells
#12
Raana Farajzadeh, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Shahrzad Javidfar, Javid Lotfi-Attari, Hadi Sadeghzadeh, Vahid Shafiei-Irannejad, Nosratollah Zarghami
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen of nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met and Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) and evaluated for their therapeutic efficacy. The morphology and dynamic light scattering (DLS) analyses were carried out to optimize the nanoformulations. Drug release study was performed using dialysis method and then the cytotoxic and inhibitory effect of individual and combined drugs on expression level of hTERT in T47D breast cell line were evaluated using MTT assay and qPCR, respectively...
July 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28678264/self-assembled-nanocapsules-in-water-a-molecular-mechanistic-study
#13
Hang Xiao, Xiaoyang Shi, Xi Chen
The self-assembly mechanism of one-end-open carbon nanotubes (CNTs) suspended in an aqueous solution was studied by molecular dynamics simulations. It was shown that two one-end-open CNTs with different diameters can coaxially self-assemble into a nanocapsule. The nanocapsules formed were stable in aqueous solution under ambient conditions, and the pressure inside the nanocapsule was much higher than the ambient pressure due to the van der Waals interactions between the two parts of the nanocapsule. The effects of the normalized radius difference, normalized inter-tube distance and aspect ratio of the CNT pairs were systematically explored...
July 5, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28663087/superiority-of-aromatase-inhibitor-and-cyclooxygenase-2-inhibitor-combined-delivery-hyaluronate-targeted-versus-pegylated-protamine-nanocapsules-for-breast-cancer-therapy
#14
Ahmed O Elzoghby, Shaimaa K Mostafa, Maged W Helmy, Maha A ElDemellawy, Salah A Sheweita
Despite several reports have revealed the beneficial effect of co-administration of COX-2 inhibitors with aromatase inhibitors in managing postmenopausal breast cancer; no nanocarriers for such combined delivery have been developed till now. Therefore, protamine nanocapsules (PMN-NCs) have been developed to co-deliver letrozole (LTZ) that inhibits aromatase-mediated estrogen biosynthesis and celecoxib (CXB) that synergistically inhibits aromatase expression. Inspired by the CD44-mediated tumor targeting ability of hyaluronate (HA), we developed HA-coated PMN-NCs (HA-NCs) via electrostatic layer-by-layer assembly...
June 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28653597/lipid-core-nanocapsules-increase-the-oral-efficacy-of-quercetin-in-cutaneous-leishmaniasis
#15
A J Sousa-Batista, F S Poletto, C I M S Philipon, S S Guterres, A R Pohlmann, B Rossi-Bergmann
New oral treatments are needed for all forms of leishmaniasis. Here, the improved oral efficacy of quercetin (Qc) and its penta-acetylated derivative (PQc) was evaluated in cutaneous leishmaniasis after encapsulation in lipid-core nanocapsules (LNCs) of poly(ε-caprolactone). Leishmania amazonensis-infected BALB/c mice were given 51 daily oral doses of free drugs (16 mg kg-1) or LNC-loaded drugs (0·4 mg kg-1). While treatment with free Qc reduced the lesion sizes and parasite loads by 38 and 71%, respectively, LNC-Qc produced 64 and 91% reduction, respectively...
June 27, 2017: Parasitology
https://www.readbyqxmd.com/read/28651193/p-p-methoxyl-diphenyl-diselenideincorporation-into-polymeric-nanocapsules-improves-its-antinociceptive-action-physicochemical-and-behavioral-studies
#16
Marcel Henrique Marcondes Sari, Luana Mota Ferreira, Vanessa AngonesiZborowski, Paulo Cesar Oliveira Araujo, Jessica Mendes Nadal, Paulo Vitor Farago, Letícia Cruz, Cristina Wayne Nogueira
The p,p'-methoxyl-diphenyl diselenide [(OMePhSe)2] is an, organoselenium compound that elicits antinociceptive action in different, animal models of pain. However, the compound has physicochemical, Limitations that delay its clinical studies. Herein, (OMePhSe)2, nanocapsules were developed and their physicochemical properties were, analyzed using different techniques (Scanning electron microscopy with, field emissionguns, wide-angle X-ray diffractometry, fourier-transform, infrared spectroscopy, thermogravimetric analysis and differential, scanning calorimetry)...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28643777/in-situ-targeted-mri-detection-of-helicobacter-pylori-with-stable-magnetic-graphitic-nanocapsules
#17
Yunjie Li, Xiaoxiao Hu, Ding Ding, Yuxiu Zou, Yiting Xu, Xuewei Wang, Yin Zhang, Long Chen, Zhuo Chen, Weihong Tan
Helicobacter pylori infection is implicated in the aetiology of many diseases. Despite numerous studies, a painless, fast and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymatic environment of the gastric mucosa. Herein, we report the use of stable magnetic graphitic nanocapsules (MGNs), for in situ targeted magnetic resonance imaging (MRI) detection of H. pylori. Several layers of graphene as the shell effectively protect the magnetic core from corrosion while retaining the superior contrast effect for MRI in the gastric environment...
June 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28643236/multi-reservoir-phospholipid-shell-encapsulating-protamine-nanocapsules-for-co-delivery-of-letrozole-and-celecoxib-in-breast-cancer-therapy
#18
Ahmed O Elzoghby, Shaimaa K Mostafa, Maged W Helmy, Maha A ElDemellawy, Salah A Sheweita
PURPOSE: In the current work, we propose a combined delivery nanoplatform for letrozole (LTZ) and celecoxib (CXB). METHODS: Multi-reservoir nanocarriers were developed by enveloping protamine nanocapsules (PRM-NCs) within drug-phospholipid complex bilayer. RESULTS: Encapsulation of NCs within phospholipid bilayer was confirmed by both size increase from 109.7 to 179.8 nm and reduction of surface charge from +19.0 to +7.78 mV. The multi-compartmental core-shell structure enabled biphasic CXB release with initial fast release induced by complexation with phospholipid shell followed by prolonged release from oily core...
June 22, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28641543/zein-based-nanocarriers-as-potential-natural-alternatives-for-drug-and-gene-delivery-focus-on-cancer-therapy
#19
Ahmed Elzoghby, May Freag, Hadeer Mamdouh, Kadria Elkhodairy
Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28629093/novel-pemulen-pullulan-blended-hydrogel-containing-clotrimazole-loaded-cationic-nanocapsules-evaluation-of-mucoadhesion-and-vaginal-permeation
#20
Julia A de Lima, Thamiris C Paines, Mariana H Motta, Watussi B Weber, Sara S Dos Santos, Letícia Cruz, Cristiane de B da Silva
In this work, hydrogels containing clotrimazole-loaded nanocapsules were developed through the innovative association of two mucoadhesive polymers: Pemulen® TR1 and Pullulan. Furthermore, the hydrogels macroscopic characteristics, pH and spreadability were evaluated. The formulations showed homogeneous appearance and pH compatible with vaginal application (around 5.0). Similar spreadability profiles were found in hydrogels containing clotrimazole-loaded nanocapsules and in the free drug as well. Hydrogels were evaluated considering their mucoadhesive potential by the falling liquid film method and the permeation/penetration capacity through cow vaginal mucosa in Franz cell...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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