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Leonardo Q S Lopes, Cayane G Santos, Rodrigo de Almeida Vaucher, Renata P Raffin, Aleksandro S da Silva, Dilmar Baretta, Ana Paula Maccari, Laura Caroline D D Giombelli, Andreia Volpato, Jessyka Arruda, Cecília de Ávila Scheeren, Bernardo Baldisserotto, Roberto C V Santos
Glycerol Monolaurate (GML) is a compound with known antimicrobial potential, however it is not much used due to its low solubility in water and high melting point. The nanoencapsulation of some drugs offers several advantages such as improved stability and solubility in water. The present study aimed to produce, characterize, and evaluate the ecotoxicity of GML nanocapsules. The nanocapsules were produced and presented a mean diameter of 210nm, polydispersity index of 0.044, and zeta potential of -23.4mV. The electron microscopy images showed the nanometric size and spherical shape...
January 19, 2017: Ecotoxicology and Environmental Safety
Janina Jiang, Guangchao Liu, Valerie A Kickhoefer, Leonard H Rome, Lin-Xi Li, Stephen J McSorley, Kathleen A Kelly
Chlamydia trachomatis genital infection is the most common sexually transmitted bacterial disease, causing a significant burden to females due to reproductive dysfunction. Intensive screening and antibiotic treatment are unable to completely prevent female reproductive dysfunction, thus, efforts have become focused on developing a vaccine. A major impediment is identifying a safe and effective adjuvant which induces cluster of differentiation 4 (CD4) cells with attributes capable of halting genital infection and inflammation...
January 19, 2017: Vaccines
Viridiana Gisela Llera-Rojas, L Alicia Del Real, Néstor Mendoza-Muñoz, Luz María Melgoza-Contreras, David Quintanar-Guerrero
Nanocapsules (NCs) are submicron-sized core shell systems which present important advantages such as improvement of drug efficacy and bioavailability, prevention of drug degradation, and provision of controlled-release delivery. The available methods for NC production require expensive recovery and purification steps which compromised the morphology of nanocapsules. Industrial applications of NCs have been avoided due to the aforementioned issues. In this study, we developed a new method based on a modified self automicroemulsifying drug delivery system (SMEDDS) for in situ NCs production within the gastrointestinal tract...
January 20, 2017: Drug Development and Industrial Pharmacy
Urszula Bazylińska, Jadwiga Pietkiewicz, Joanna Rossowska, Grzegorz Chodaczek, Andrzej Gamian, Kazimiera A Wilk
The authors examine properties of daunorubicin (DNR)-loaded oil-core multilayer nanocapsules prepared via layer-by-layer approach with different polyelectrolyte (PE) coatings such as a standard one (containing polysodium 4-styrenesulphonate/poly(diallyldimethyl-ammonium) chloride) and a polysaccharide-based shell (dextran/chitosan), in regard to the outer layer of poly-l-glutamic acid (PGA) grafted with polyethylene glycol (PGA-g-PEG). The nanocarriers are obtained on a cationic nanoemulsion template (stabilized by dicephalic-type surfactant, N,N-bis[3,30-(trimethylammonio)propyl]-dodecanamide dimethylsulfate) and layered with the PE shell of different thicknesses resulting in average size of 150 nm in diameter (as shown by dynamic light scattering, scanning electron microscopy and cryogenic-transmission electron microscopy, and atomic force microscopy)...
January 17, 2017: Macromolecular Bioscience
Xibo Yan, Pierre Alcouffe, Guillaume Sudre, Laurent David, Julien Bernard, Francois Ganachaud
Formation of O/W surfactant-free microemulsions from water/oil/acetone ternary systems is exploited to construct precisely-defined shell-functionalized core-loaded nanocapsules with tunable diameters (ranging from 50 to 190 nm) in one step.
January 12, 2017: Chemical Communications: Chem Comm
Fernanda C Flores, Roberta S Rosso, Letícia Cruz, Ruy C R Beck, Cristiane B Silva
Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems presented a nanometric size around 155nm for uncoated nanoparticles and 162nm for those with the cationic coating, with negative and positive zeta potential values, respectively. Both nanosuspensions showed drug content close to theoretical values (1mgmL(-1)), association efficiency close to 100% (HPLC) and were able to control tioconazol release. The developed formulations showed in vitro antifungal activity (agar diffusion method) against C...
January 5, 2017: European Journal of Pharmaceutical Sciences
Sreedevi Krishnakumar, Karical R Gopidas
A simple method for covalent functionalization of Fréchet-type dendron nanoparticles (FDN) by tris-bipyridylruthenium(II) is described. Covalent functionalization is achieved by chemically reducing the diazo derivative of a ruthenium(II) bipyridine complex in the presence of FDNs wherein the radical species generated gets covalently linked to the nanoparticle surface. Simplicity, rapidity and robustness are the advantages offered by the present approach. The nanoparticles, post functionalization, were characterized by transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDX), thermogravimetric analysis (TGA), and IR, UV-visible, and NMR spectroscopic techniques...
January 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Balasubramanian Sivakumar, Ravindran Girija Aswathy, Rebeca Romero-Aburto, Trevor Mitcham, Keith A Mitchel, Yutaka Nagaoka, Richard R Bouchard, Pulickel M Ajayan, Toru Maekawa, Dasappan Nair Sakthikumar
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics...
January 6, 2017: Biomaterials Science
Ryoma Teranishi, Ryota Matsuki, Eiji Yuba, Atsushi Harada, Kenji Kono
For the delivery of doxorubicin (DOX), pH and redox dual responsive hollow nanocapsules were prepared through the stabilization of polymer vesicles, which spontaneously formed from polyamidoamine dendron-poly(l-lysine) (PAMAM dendron-PLL), by the introduction of disulfide (SS) bonds between PLLs. The SS-bonded nanocapsules exhibited a very slow release of DOX under an extracellular environment because the cationic PLL membrane acted as an electrostatic barrier against the protonated DOX molecules. However, increasing the glutathione concentration to the intracellular level facilitated the immediate release of DOX through the collapse of nanocapsules by the spontaneous cleavage of SS bonds...
December 30, 2016: Pharmaceutics
Adamo Riccardo Petosa, Faraz Rajput, Olivia Selvam, Carolin Öhl, Nathalie Tufenkji
Nanotechnology is increasingly important in the agricultural sector, with novel products being developed to heighten crop yields and increase pesticide efficacy. Herein, the transport potential of different polymeric nanocapsules (nCAPs) developed as pesticide delivery vehicles was assessed in model soil systems. The nCAPs examined are (i) poly(acrylic acid)-based (nCAP1), (ii) poly(methacrylic acid)-ran-poly(ethyl acrylate) copolymer-based (nCAP2), (iii) poly(methacrylic acid-ran-styrene) copolymer-based (nCAP3), and (iv) poly(methacrylic acid-ran-butylmethacrylate)-based (nCAP4)...
December 19, 2016: Water Research
Neetu Chauhan, Neeraj Dilbaghi, Madhuban Gopal, Rajesh Kumar, Ki-Hyun Kim, Sandeep Kumar
Accelerated use of pesticides in cutting edge agriculture prompted us to explore smart nanoformulations to subside the consumption of these perilous chemicals. Polymer nanocapsules carrying a fungicide, hexaconazole were developed through ionotropic gelation method utilizing chitosan and tripolyphosphate (TPP). The nanocapsules were characterized by photon correlation spectroscope (PCS), transmission electron microscope (TEM), and Fourier transform infra-red (FTIR) spectroscope. Nanocapsules were optimized for size and high encapsulation efficiency using central composite design (CCD) software...
December 26, 2016: International Journal of Biological Macromolecules
Sandeep Kumar, Gaurav Bhanjana, Ritesh Kumar Verma, Dinesh Dhingra, Neeraj Dilbaghi, Ki-Hyun Kim
OBJECTIVES: Present modalities for the diagnosis and treatment of diabetes still suffer from certain limitations such as erratic absorption, need of high dose, poor sensitivity or specificity, resistance, substantial morbidity and mortality, long-term complications, and patient-to-patient variability with lifetime treatment. METHODS: This study focused on the development of a water-in-oil-in-water metformin nanoemulsion as an effective method in diabetes treatment...
February 2017: Journal of Pharmacy and Pharmacology
Zhenwei Tong, Dong Yang, Zhen Li, Yanhu Nan, Fei Ding, Yichun Shen, Zhongyi Jiang
Inspired by the orderly stacked nanostructure and highly integrated function of thylakoids in a natural photosynthesis system, multishell g-C3N4 (MSCN) nanocapsule photocatalysts have been prepared by SiO2 hard template with different shell layers. The resultant triple-shell g-C3N4 (TSCN) nanocapsules display superior photocatalysis performance to single-shell and double-shell counterparts owing to excellent visible-light harvesting and electron transfer properties. Specially, with the increase of the shell layer number, light harvesting is greatly enhanced...
January 3, 2017: ACS Nano
Jingyu Ran, Lihua Xiao, Weidang Wu, Yike Liu, Wei Qiu, Jianming Wu
Hollow poly(dopamine) (PDA) nanocapsules and yolk-structured PDA nanocomposites were prepared by an aqueous one-pot synthesis method utilizing zeolitic imidazolate framework-8 (ZIF-8) nanocrystals as a sacrificial template without any special etchant. The resulting PDA nanocapsules show negligible cytotoxicity in HeLa cells after incubation for 48 h at various doses, which implies their potential as candidates for practical applications in drug transport and targeting.
February 3, 2017: Nanotechnology
Nancy L Benner, Xiaoyu Zang, Daniel C Buehler, Valerie A Kickhoefer, Michael E Rome, Leonard H Rome, Paul A Wender
Vault nanoparticles represent promising vehicles for drug and probe delivery. Innately found within human cells, vaults are stable, biocompatible nanocapsules possessing an internal volume that can encapsulate hundreds to thousands of molecules. They can also be targeted. Unlike most nanoparticles, vaults are nonimmunogenic and monodispersed and can be rapidly produced in insect cells. Efforts to create vaults with modified properties have been, to date, almost entirely limited to recombinant bioengineering approaches...
January 3, 2017: ACS Nano
Camila S Ritter, Matheus D Baldissera, Thirssa H Grando, Carine F Souza, Michele R Sagrillo, Ana Paula T da Silva, Rafael N Moresco, Naiara S Guarda, Aleksandro S da Silva, Lenita M Stefani, Silvia G Monteiro
The aim of this study was to evaluate whether the treatment with Achyrocline satureioides essential oil-loaded in nanocapsules (AS-NC) is able to protect the hepatic tissue against cytotoxic damage caused by Trypanosoma evansi. Thus, the rats were divided into four groups (n = 6 per group): uninfected/saline, uninfected/AS-NC, infected/saline, and infected/AS-NC. At day 4 post-infection (PI), the animals were euthanized and liver and sera samples were collected to perform the hepatic cell viability assay, and to determine seric levels of reactive oxygen species (ROS) and nitric oxide metabolites (NOx)...
December 25, 2016: Microbial Pathogenesis
Sergey A Dergunov, Alibek T Khabiyev, Sergey N Shmakov, Mariya D Kim, Nasim Ehterami, Mary Clare Weiss, Vladimir B Birman, Eugene Pinkhassik
Nanoreactors were created by entrapping homogeneous catalysts in hollow nanocapsules with 200 nm diameter and semipermeable nanometer-thin shells. The capsules were produced by the polymerization of hydrophobic monomers in the hydrophobic interior of the bilayers of self-assembled surfactant vesicles. Controlled nanopores in the shells of nanocapsules ensured long-term retention of the catalysts coupled with the rapid flow of substrates and products in and out of nanocapsules. The study evaluated the effect of encapsulation on the catalytic activity and stability of five different catalysts...
December 27, 2016: ACS Nano
T Hatahet, M Morille, A Shamseddin, A Aubert-Pouëssel, J M Devoisselle, S Bégu
Quercetin is a plant flavonoid with strong antioxidant and antiinflammatory properties interesting for skin protection. However, its poor water solubility limits its penetration and so its efficiency on skin. For this purpose, quercetin lipid nanocapsules were formulated implementing phase inversion technique wherein several modifications were introduced to enhance quercetin loading. Quercetin lipid nanocapsules were formulated with two particle size range, (50nm and 20nm) allowing a drug loading of 18.6 and 32mM respectively...
December 21, 2016: International Journal of Pharmaceutics
Adryana Clementino, Mellissa Batger, Gabriela Garrastazu, Michele Pozzoli, Elena Del Favero, Valeria Rondelli, Bianca Gutfilen, Thiago Barboza, Maria B Sukkar, Sergio A L Souza, Laura Cantù, Fabio Sonvico
PURPOSE: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration in view of an improved delivery of the statins to the brain...
2016: International Journal of Nanomedicine
María L Zambrano-Zaragoza, David Quintanar-Guerrero, Alicia Del Real, Elizabeth Piñon-Segundo, José F Zambrano-Zaragoza
The main aim of this work was to evaluate the effect of the β-carotene release rate from nanocapsules incorporated into a xanthan gumcoating on the physical and physicochemical properties of fresh-cut melon (var. cantaloupe). Several coatings were studied: xanthan gum alone (XG), xanthan gum combined with nanocapsules (Ncs/XG), xanthan gum combined with nanospheres (Nsp/XG), nanocapsules (Ncs), and nanospheres (Nsp), all of which were compared to untreated fresh-cut melon in order to determine their preservation efficiency...
February 10, 2017: Carbohydrate Polymers
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