Mandeep R Mehra, Ivan Netuka, Nir Uriel, Jason N Katz, Francis D Pagani, Ulrich P Jorde, Finn Gustafsson, Jean M Connors, Peter Ivak, Jennifer Cowger, John Ransom, Aditya Bansal, Koji Takeda, Richa Agarwal, Mirnela Byku, Michael M Givertz, Abbas Bitar, Shelley Hall, Daniel Zimpfer, J David Vega, Manreet K Kanwar, Omar Saeed, Daniel J Goldstein, Rebecca Cogswell, Farooq H Sheikh, Matthew Danter, Yuriy Pya, Anita Phancao, John Henderson, Daniel L Crandall, Kartik Sundareswaran, Edward Soltesz, Jerry D Estep
IMPORTANCE: Left ventricular assist devices (LVADs) enhance quality and duration of life in advanced heart failure. The burden of nonsurgical bleeding events is a leading morbidity. Aspirin as an antiplatelet agent is mandated along with vitamin K antagonists (VKAs) with continuous-flow LVADs without conclusive evidence of efficacy and safety. OBJECTIVE: To determine whether excluding aspirin as part of the antithrombotic regimen with a fully magnetically levitated LVAD is safe and decreases bleeding...
November 11, 2023: JAMA