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Continuous flow left ventricular assist device

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https://www.readbyqxmd.com/read/27885993/arterial-pulsatility-under-phasic-left-ventricular-assist-device-support
#1
Selim Bozkurt, Sjoerd van Tuijl, Frans N van de Vosse, Marcel C M Rutten
The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27867617/bleeding-in-continuous-flow-left-ventricular-assist-device-recipients-an-acquired-vasculopathy
#2
EDITORIAL
Snehal R Patel, Sasa Vukelic, Ulrich P Jorde
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27863356/left-ventricular-assist-devices-and-gastrointestinal-evaluation-results-of-a-consecutive-case-series
#3
Sultan Alotaibi, Raimund Erbel, Till Neumann
AIMS: To evaluate the benefit of preoperative gastrointestinal endoscopic evaluation in patients undergoing continuous flow left ventricular assist devices (CF-LVADs) implantation. METHODS AND RESULTS: A retrospective review of all fifty-three patients undergoing CF-LVADs at West-German Heart and Vascular Center, University of Duisburg-Essen was performed. A routine preoperative esophagogastroduodenoscopy was performed in seven patients to assess gastrointestinal (GI) bleeding...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861429/clinical-implications-of-physiological-flow-adjustment-in-continuous-flow-left-ventricular-assist-devices
#4
Vakhtang Tchantchaleishvili, Jessica G Y Luc, Caitlin M Cohan, Kevin Phan, Laila Hübbert, Steven W Day, H Todd Massey
There is increasing evidence for successful management of end-stage heart failure with continuous-flow left ventricular assist device (CF-LVAD) technology. However, passive flow adjustment at fixed CF-LVAD speed is susceptible to flow balancing issues as well as adverse hemodynamic effects relating to the diminished arterial pulse pressure and flow. With current therapy, flow cannot be adjusted with changes in venous return, which can vary significantly with volume status. This limits the performance and safety of CF-LVAD...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27858326/left-ventricular-assist-devices-impact-hospital-resource-utilization-without-affecting-patient-mortality-in-gastrointestinal-bleeding
#5
Feng Li, Alice Hinton, Alan Chen, Nishaki K Mehta, Samer Eldika, Cheng Zhang, Hisham Hussan, Darwin L Conwell, Somashekar G Krishna
BACKGROUND: Left ventricular assist devices (LVADs) are being utilized for management of end-stage heart failure and require systemic anticoagulation. Gastrointestinal bleeding (GIB) is one of the most common adverse events following LVAD implantation. AIM: To investigate the impact of continuous-flow (CF) LVAD implants on outcomes of patients admitted with GIB. METHODS: This is a cross-sectional study utilizing the Nationwide Inpatient Sample in the CF-LVAD era from 2010 to 2012...
November 17, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27852651/emergency-procedures-for-patients-with-a-continuous-flow-left-ventricular-assist-device
#6
Juliane Vierecke, Martin Schweiger, David Feldman, Evgenij Potapov, Friedrich Kaufmann, Lorenzo Germinario, Roland Hetzer, Volkmar Falk, Thomas Krabatsch
The number of ventricular assist devices (VADs) being implanted for terminal heart failure is rising at an exponential rate. These implanted patients have a decreased mortality, but still have significant morbidities, as the prevalence of these patients increases in the community. When VAD patients are discharged to home, they will very likely require emergency medical services (EMSs) and emergency medical doctors (EDs) with their future care. The interface of these patients with the community would suggest an increasing prevalence of encounters requiring the need for acute medical care...
November 15, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27836023/coagulation-factor-abnormalities-related-to-discordance-between-anti-factor-xa-and-activated-partial-thromboplastin-time-in-patients-supported-with-continuous-flow-left-ventricular-assist-devices
#7
Sirtaz Adatya, Roy Sunny, Megan J Fitzpatrick, Monica Colvin, Thennapan Thennapan, Ranjit John, Nicole Dodge Zantek, Marc Pritzker, Peter Eckman, Nir Uriel
BACKGROUND: High levels of discordance between activated partial thromboplastin time (aPTT) and anti-factor Xa (anti-FXa) have been reported in patients with continuous-flow left ventricular assist devices (CF-LVADs). We sought to determine the biochemical basis for discordance by simultaneous measurement of coagulation factors with aPTT and anti-FXa. METHODS: Consecutive CF-LVAD patients admitted for intravenous unfractionated heparin (IV-UFH) therapy were studied...
November 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27816511/does-small-size-matter-with-continuous%C3%A2-flow-devices-analysis-of-the-intermacs-database-of-adults-with-bsa%C3%A2-%C3%A2-1-5-m-2
#8
Farhan Zafar, Chet R Villa, David L Morales, Elizabeth D Blume, David N Rosenthal, James K Kirklin, Angela Lorts
OBJECTIVES: This study investigated how small patient size affects clinical outcomes in patients implanted with a continuous flow left ventricular assist device (CFLVAD). BACKGROUND: The development of smaller CFLVADs has allowed ventricular assist device (VAD) use in anatomically smaller patients; however, limited outcome data exist regarding CFLVAD use in patients with a body surface area (BSA) ≤1.5 m(2). METHODS: All CFLVAD patients entered in the Interagency Registry for Mechanically Assisted Circulatory Support registry April 2008 to September 2013 and with BSA data were included...
October 27, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27798492/associations-of-preimplant-red-blood-cell-distribution-width-with-clinical-outcomes-among-individuals-with-left-ventricular-assist-devices
#9
P Elliott Miller, Brian A Houston, Andrea L C Schneider, Aaron L Bush, Glenn J Whitman, Gerin R Stevens, Ryan J Tedford, Stuart D Russell
Left ventricular assist devices (LVADs) are increasingly used for end-stage heart failure. However, post-LVAD complications are potentially devastating and remain unpredictable. The red blood cell distribution width (RDW) is a predictor of adverse events in patients with heart failure but has not been studied in the LVAD population. We reviewed laboratory results and clinical outcomes for all continuous flow LVADs implanted from 2004 to June 2014 (N = 188). Cox proportional hazards models adjusted for demographic, cardiovascular, and laboratory variables were used to assess association of preimplant RDW tertiles with mortality, gastrointestinal bleed, infection, pump thrombosis, and stroke more than 1 year of follow-up...
November 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27782305/pulse-oximeter-derived-blood-pressure-measurement-in-patients-with-a-continuous-flow-left-ventricular-assist-device
#10
Yaron Hellman, Adnan S Malik, Kathleen A Lane, Changyu Shen, I-Wen Wang, Thomas C Wozniak, Zubair A Hashmi, Sarah D Munson, Jeanette Pickrell, Marco A Caccamo, Irmina Gradus-Pizlo, Azam Hadi
Currently, blood pressure (BP) measurement is obtained noninvasively in patients with continuous flow left ventricular assist device (LVAD) by placing a Doppler probe over the brachial or radial artery with inflation and deflation of a manual BP cuff. We hypothesized that replacing the Doppler probe with a finger-based pulse oximeter can yield BP measurements similar to the Doppler derived mean arterial pressure (MAP). We conducted a prospective study consisting of patients with contemporary continuous flow LVADs...
October 26, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27780579/intra-aortic-balloon-pumps-and-continuous-flow-left-ventricular-assist-devices-don-t-let-balloon-pumps-overstay-their-welcome
#11
EDITORIAL
Kevin G Soucy, Steven C Koenig, Mark S Slaughter
No abstract text is available yet for this article.
September 24, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27779786/positive-impact-of-continuous-flow-left-ventricular-assist-device-implantation-on-glycemic-control-in-patients-with-type-2-diabetes-mellitus-and-advanced-chronic-systolic-heart-failure
#12
Debbie C Yen, Mara H Watson, Lindsey D Burgess, Maragatha Kuchibhatla, Chetan B Patel, Kristen B Campbell, Alyssa K Vora
STUDY OBJECTIVE: To evaluate the impact of continuous-flow left ventricular assist device (LVAD) implantation on glycemic control in patients with type 2 diabetes mellitus and advanced chronic systolic heart failure. DESIGN: Retrospective medical record review. SETTING: Large, academic, tertiary and quaternary care hospital. PATIENTS: Eighty-three adults with type 2 diabetes mellitus and advanced chronic systolic heart failure who underwent implantation of a continuous-flow LVAD between July 1, 2008, and June 30, 2013...
October 25, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27773451/discriminatory-performance-of-positive-urine-hemoglobin-for-detection-of-significant-hemolysis-in-patients-with-continuous-flow-left-ventricular-assist-devices
#13
Michael V Gavalas, Alexander Breskin, Melana Yuzefpolskaya, Andrew Eisenberger, Francesco Castagna, Ryan T Demmer, Margaret Flannery, A Reshad Garan, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Veli K Topkara, Paolo C Colombo
BACKGROUND: Serum lactate dehydrogenase (LDH) is the standard measure for detection of hemolysis and thus surveillance for device thrombosis in patients on continuous-flow left ventricular assist device (CF-LVAD) support. Significant hemolysis has been defined as LDH ≥600 IU/L. However, LDH testing requires phlebotomy, precluding frequent home monitoring. Simple dipstick urinalysis (UA) for urine hemoglobin (U-Hb) overcomes this limitation. This study correlated U-Hb and LDH levels and evaluated the performance of UA for detection of significant hemolysis in patients with CF-LVADs...
September 13, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27765670/ventricular-assist-device-therapy-in-older-patients-with-heart-failure-characteristics-and-outcomes
#14
Ju H Kim, Ramesh Singh, Francis D Pagani, Shashank S Desai, Nicholas A Haglund, Shannon M Dunlay, Simon Maltais, Keith D Aaronson, John M Stulak, Mary E Davis, Christopher T Salerno, Jennifer A Cowger, Palak Shah
BACKGROUND: Limited data exist on outcomes in patients ≥70 years of age supported with the use of continuous-flow left ventricular assist devices (LVADs). METHODS: Data on 1149 continuous-flow LVAD recipients was queried from the Mechanical Circulatory Support Research Network. Groups were assigned based on age: ≥70 years ("older patients") and <70 years. The primary outcome was survival at one-year based on age grouping. RESULTS: Compared with younger patients (54...
October 17, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27744498/central-aortic-valve-closure-successfully-treated-aortic-insufficiency-of-the-patient-with-jarvik-2000-continuous-flow-left-ventricular-assist-device-a-case-report
#15
Yoshifumi Itoda, Kan Nawata, Haruo Yamauchi, Osamu Kinoshita, Mitsutoshi Kimura, Minoru Ono
Aortic insufficiency (AI) is a significant complication of long-term support of continuous flow left ventricular assist device (CF-LVAD) for patients with end-stage heart failure. A 26-year-old female with osteogenesis imperfecta (OI) was diagnosed with dilated phase hypertrophic cardiomyopathy (d-HCM)) and was implanted with Jarvik 2000, for bridge to transplantation. AI gradually developed and surgical intervention was indicated. We performed central aortic valve closure (CAVC) instead of valve replacement 20 months after CF-LVAD implantation...
October 15, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27744088/association-of-nasal-mucosal-vascular-alterations-gastrointestinal-arteriovenous-malformations-and-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#16
Snehal R Patel, Shivank Madan, Omar Saeed, Mohammed Algodi, Anne Luke, Marc Gibber, Daniel J Goldstein, Ulrich P Jorde
OBJECTIVES: This study sought to determine whether the nasal mucosa can serve as a surrogate for evaluating arteriovenous malformations (AVMs) related gastrointestinal (GI) bleeding in patients supported by continuous flow left ventricular assist devices (CF LVADs). BACKGROUND: Bleeding from the mucosal surfaces of GI tract, particularly AVMs, is the most common complication of CF LVAD support. The pathophysiology of AVM formation during CF LVAD support is of critical interest yet poorly understood; in large part because of the length and accessibility of the GI tract...
September 29, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27737740/impact-of-ischemic-heart-failure-etiology-on-cardiac-recovery-during-mechanical%C3%A2-unloading
#17
James Wever-Pinzon, Craig H Selzman, Greg Stoddard, Omar Wever-Pinzon, Anna Catino, Abdallah G Kfoury, Nikolaos A Diakos, Bruce B Reid, Stephen McKellar, Michael Bonios, Antigone Koliopoulou, Deborah Budge, Aaron Kelkhoff, Josef Stehlik, James C Fang, Stavros G Drakos
BACKGROUND: Small-scale studies focused mainly on nonischemic cardiomyopathy (NICM) have shown that a subset of left ventricular assist device (LVAD) patients can achieve significant improvement of their native heart function, but the impact of ischemic cardiomyopathy (ICM) has not been specifically investigated. Many patients with acute myocardial infarction are discharged from their index hospitalization without heart failure (HF), only to return much later with overt HF syndrome, mainly caused by chronic remodeling of the noninfarcted region of the myocardium...
October 18, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27717495/intra-aortic-balloon-pump-therapy-negatively-affects-flow-through-a-continuous-flow-left-ventricular-assist-device
#18
Dipanjan Banerjee, Chun Choi, Richard Ha
No abstract text is available yet for this article.
September 17, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27717422/left-ventricular-assist-device-design-reduces-von-willebrand-factor-degradation-a-comparative-study-between-the-heartmate-ii-and-the-evaheart-left-ventricular-assist-system
#19
Carlo R Bartoli, Jooeun Kang, David Zhang, Jessica Howard, Michael Acker, Pavan Atluri, Tadashi Motomura
BACKGROUND: Supraphysiologic shear stress from continuous-flow left ventricular assist devices (LVADs) accelerates von Willebrand factor (vWF) degradation and predisposes patients to nonsurgical bleeding. It is unknown whether unique design characteristics of LVADs differentially affect vWF degradation. We tested the hypothesis that the centrifugal-flow EVAHEART (Evaheart, Houston, TX) left ventricular assist system (LVAS), which was designed to minimize shear stress (low operational revolutions per minute [rpm], larger flow gaps, low shear stress, flat H-Q curve), reduced vWF degradation versus the axial-flow HeartMate II (Thoratec, Pleasanton, CA) LVAD...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27707562/spanish-heart-transplantation-registry-27th-official-report-of-the-spanish-society-of-cardiology-working-group-on-heart-failure-and-heart-transplantation-1984-2015
#20
Francisco González-Vílchez, Javier Segovia Cubero, Luis Almenar, María G Crespo-Leiro, José M Arizón, Iago Sousa, Juan Delgado, Eulalia Roig, José Manuel Sobrino, José González-Costello
INTRODUCTION AND OBJECTIVES: The present article reports the characteristics and results of heart transplants in Spain since this therapeutic modality was first used in May 1984. METHODS: We describe the main features of recipients, donors, surgical procedures, and results of all heart transplants performed in Spain until December 31, 2015. RESULTS: A total of 299 cardiac transplants were performed in 2015, with the whole series comprising 7588 procedures...
October 1, 2016: Revista Española de Cardiología
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