Ellen Singleton, Oskar Hansson, Yolande A L Pijnenburg, Renaud La Joie, William G Mantyh, Pontus Tideman, Erik Stomrud, Antoine Leuzy, Maurits Johansson, Olof Strandberg, Ruben Smith, Evi Berendrecht, Bruce L Miller, Leonardo Iaccarino, Lauren Edwards, Amelia Strom, Emma E Wolters, Emma Coomans, Denise Visser, Sandeep S V Golla, Hayel Tuncel, Femke Bouwman, John Cornelis Van Swieten, Janne M Papma, Bart van Berckel, Philip Scheltens, Anke A Dijkstra, Gil D Rabinovici, Rik Ossenkoppele
OBJECTIVE: The clinical phenotype of the rare behavioural variant of Alzheimer's disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using positron emission tomography (PET) and postmortem examination. METHODS: For the tau PET study, seven amyloid-β positive bvAD patients underwent [18 F]flortaucipir or [18 F]RO948 PET...
April 13, 2021: Journal of Neurology, Neurosurgery, and Psychiatry