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https://www.readbyqxmd.com/read/28229990/clinical-analysis-of-postpartum-hemorrhage-requiring-massive-transfusions-at-a-tertiary-center
#1
Jun Hu, Zhu-Ping Yu, Peng Wang, Chun-Yan Shi, Hui-Xia Yang
BACKGROUND: The reports on massive transfusions (MTs) in obstetrics have recently been an increasing trend. We aimed to define the clinical features, risk factors, main causes, and outcomes of MTs due to severe postpartum hemorrhage (PPH) and the frequency trends over the past 10 years. METHODS: We retrospectively analyzed the data of 3552 PPH patients who were at ≥28 weeks of gestation in the Obstetric Department of Peking University First Hospital from January 2006 to February 2015...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28213385/effectiveness-of-acarbose-in-treating-elderly-patients-with-diabetes-with-postprandial-hypotension
#2
Jie Zhang, Lixin Guo
: : Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose...
February 17, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28195653/duration-of-second-stage-of-labour-at-term-and-pushing-time-risk-factors-for-postpartum-haemorrhage
#3
Emelie Looft, Marija Simic, Mia Ahlberg, Jonathan M Snowden, Yvonne W Cheng, Olof Stephansson
BACKGROUND: Prolonged labour is associated with increased risk of postpartum haemorrhage (PPH), but the role of active pushing time and the relation with management during labour remains poorly understood. METHODS: A population-based cohort study from electronic medical record data in the Stockholm-Gotland Region, Sweden. We included 57 267 primiparous women with singleton, term gestation, livebirths delivered vaginally in cephalic presentation in 2008-14. We performed multivariable Poisson regression to estimate the association between length of second stage, pushing time, and PPH (estimated blood loss >500 mL during delivery), adjusting for maternal, delivery, and fetal characteristics as potential confounders...
March 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28195406/synthesis-biological-evaluations-and-molecular-docking-studies-on-dna-binding-interaction-of-platinum-ii-rollover-complexes-containing-phosphorus-donor-ligands
#4
Masood Fereidoonnezhad, Maryam Niazi, Mahnaz Shahmohammadi Beni, Shima Mohammadi, Zeinab Faghih, Zahra Faghih, Hamid R Shahsavari
A series of cyclometalated rollover complexes [PtMe(κ²N,C-bipyO-H)(L)], 2a-2c, bipyO-H = cyclometalated 2,2'-bipyridine N-oxide, L = PCy₃ (2a), PPh₂py (2-(diphenylphosphino)pyridine, 2b), P(OPh)₃ (2c), was synthesized by reacting of complex [PtMe(κ²N,C-bipyO-H)(SMe₂)], 1, with various monodentate phosphine and phosphite ligands. These complexes were characterized by means of NMR spectroscopy and the structures of 2a confirmed by single-crystal X-ray diffraction. 1 was treated with bis(diphenylphosphino)methane (dppm) in a 1 : 1 ratio to give corresponding complex [PtMe(κ²N,C-bipyO-H)(η¹P-dppm)], 3b, in which dppm ligand acts as a monodentate pendant ligand...
February 14, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28182668/cross-sectional-study-of-mode-of-delivery-and-maternal-and-perinatal-outcomes-in-mainland-china
#5
Lei Hou, Susan Hellerstein, Allison Vitonis, Liying Zou, Yan Ruan, Xin Wang, Weiyuan Zhang
BACKGROUND: Cesarean delivery (CD) rates have risen globally with nearly 50% of the non-indicated CDs worldwide in China and Brazil. In China's One Child Policy era (1979-2015) most deliveries were women having their only child. Family size is a major determinant of the safety of medically non-indicated CD or CD on maternal request. The goal of this study is to document CD rates, indications, and analyze the relative safety of non-indicated CD compared to SVD and intrapartum CD. METHODS: Univariate and multivariate logistic regression analyses of the association between mode of delivery and short-term maternal and perinatal outcomes were performed on a cross-section of all deliveries at 39 hospitals in 14 provinces of China in 2011, presented as adjusted odds ratio (aOR), 99% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28182160/curcumin-coordinated-nanoparticles-with-improved-stability-for-reactive-oxygen-species-responsive-drug-delivery-in-lung-cancer-therapy
#6
Cheng-Qiong Luo, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Bao-An Chen, Liang Jin, Hu-Lin Jiang
BACKGROUND: The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. MATERIALS AND METHODS: We synthesized a highly biocompatible 4-(hydroxymethyl) phenylboronic acid (HPBA)-modified poly(ethylene glycol) (PEG)-grafted poly(acrylic acid) polymer (PPH) and fabricated a Cur-coordinated ROS-responsive nanoparticle (denoted by PPHC) based on the interaction between boronic acid and Cur...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28176919/management-of-obstetric-postpartum-hemorrhage-a-national-service-evaluation-of-current-practice-in-the-uk
#7
Bassel H Al Wattar, Jennifer A Tamblyn, William Parry-Smith, Mathew Prior, Helen Van Der Nelson
BACKGROUND: Postpartum hemorrhage (PPH) continues to be one of the major causes of maternal mortality and morbidity in obstetrics. Variations in practice often lead to adverse maternity outcomes following PPH. Our objective was to assess the current practice in managing PPH in the UK. METHODS: We performed a national multicenter prospective service evaluation study over one calendar month and compared the current performance to national standards for managing PPH...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28167311/simulation-training-program-for-midwives-to-manage-postpartum-hemorrhage-a-randomized-controlled-trial
#8
Chiho Kato, Yaeko Kataoka
PURPOSE: To explore the effectiveness of a simulation training program for midwives in performance and knowledge for the management of postpartum hemorrhage (PPH). METHODS: The study design was a randomized controlled trial. Midwives working at one obstetrics ward in an urban area were randomly assigned to simulation training program or no training. This "simulation program" included pre study e-learning and simulation. Inclusion criteria were midwives who: 1) had two or three years of clinical experience, 2) worked in an obstetrics ward, and 3) had experience with birth assistance...
January 20, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28159274/immunomodulatory-activity-of-protein-hydrolysates-derived-from-virgibacillus-halodenitrificans-sk1-3-7-proteinase
#9
Tidarat Toopcham, Jurriaan J Mes, Harry J Wichers, Jirawat Yongsawatdigul
Modulation of inflammation-related immune response on THP-1 macrophages of protein hydrolysates derived from tilapia mince, casein and pea protein, were investigated. The protein substrates were hydrolyzed by Virgibacillus halodenitrificans SK1-3-7 proteinase. The degree of hydrolysis (DH) of casein was observed to be the highest throughout the course of hydrolysis. When challenging THP-1 macrophages, tilapia mince hydrolysate (TMH) enhanced innate immunity through induction of IL-1β and COX-2 expression. Anti-inflammatory activity was observed in casein hydrolysate (CH) and pea protein hydrolysate (PPH) by attenuating lipopolysaccharide- (LPS) induced pro-inflammatory gene expression in THP-1 macrophages...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28149307/a-novel-atraumatic-tourniquet-technique-for-excessive-bleeding-during-cesarean-sections
#10
Baris Buke, Emre Canverenler, Hatice Akkaya, Fuat Akercan
Objective. Controlling excessive bleeding in cesarean sections which may cause a life-threatening event even under well-prepared conditions. We used a novel atraumatic tourniquet technique to temporary arrest blood flow through the uterine and ovarian vessels and compare with other techniques. Toothless vascular clamps were used as clamp. Methods. Tourniquet technique performed postpartum hemorrhage (PPH) cases (19 out of 37) were compared with 18 other cases with PPH. Results. The difference between preoperative and postoperative hemoglobin values was significantly lower in the study group as well as the number of blood products needed during and after surgery...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28108900/a-case-study-of-ciliary-detachment-with-primary-pulmonary-hypertension
#11
Zhuolei Feng, Li Dong, Junxian Cao, Jie Bai, Ming-Ming Yang, Yi Zheng, Daohong Lin
PURPOSE: To introduce a case of ciliary detachment with primary pulmonary hypertension (PPH). METHODS: The clinical manifestations of a case of ciliary detachment with PPH were addressed by comprehensive examination including ultrasound biological microscope (UBM), intraocular pressure, color fundus photographs, fluorescence fundus angiography (FFA). In addition, echocardiography is used to measure primary pulmonary pressure. RESULTS: When the echocardiography displayed a systolic pulmonary arterial pressure of 106 mmHg, UBM exhibited ciliochoroidal detachment, as well as peripheral retinal effusion and non-perfusion areas in FFA...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28107460/the-incidence-of-postpartum-hemorrhage-in-pregnant-women-with-placenta-previa-a-systematic-review-and-meta-analysis
#12
Dazhi Fan, Qing Xia, Li Liu, Shuzhen Wu, Guo Tian, Wen Wang, Song Wu, Xiaoling Guo, Zhengping Liu
BACKGROUND: The global burden of postpartum hemorrhage (PPH) in women with placenta previa is a major public health concern. Although there are different reports on the incidence of PPH in different countries, to date, no research has reviewed them. OBJECTIVE: The aim of this study was to calculate the average point incidence of PPH in women with placenta previa. METHODS: A systematic review and meta-analysis of observational studies estimating PPH in women with placenta previa was conducted through literature searches in four databases in Jul 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28099749/a-systematic-review-of-maternal-near-miss-and-mortality-due-to-postpartum-hemorrhage
#13
REVIEW
Salome Maswime, Eckhart Buchmann
BACKGROUND: Postpartum hemorrhage (PPH) is the principal direct cause of maternal mortality worldwide. Analysis of maternal near miss could increase understanding of survival among women with life-threatening PPH. OBJECTIVES: To determine the near-miss ratio and maternal mortality index for PPH globally. SEARCH STRATEGY: A prevalence systematic review was conducted of English-language articles published from 1995 to 2014. Suitable articles were identified from the Scopus, PubMed, Embase, and Grey Literature databases...
January 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28096189/suppressor-of-overexpression-of-co-1-negatively-regulates-dark-induced-leaf-degreening-and-senescence-by-directly-repressing-pheophytinase-and-other-senescence-associated-genes-in-arabidopsis
#14
Junyi Chen, Xiaoyu Zhu, Jun Ren, Kai Qiu, Zhongpeng Li, Zuokun Xie, Jiong Gao, Xin Zhou, Benke Kuai
Although the biochemical pathway of chlorophyll (Chl) degradation has been largely elucidated, how Chl is rapidly yet coordinatedly degraded during leaf senescence still remains elusive. Pheophytinase (PPH) is the enzyme for catalyzing the removal of phytol group from Phein a, and PPH expression is significantly induced during leaf senescence. To elucidate the transcriptional regulation of PPH, we used yeast one-hybrid system to screen for its trans-regulators. SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1), a key flowering pathway integrator, was initially identified as one of the putative trans-regulators of PPH...
January 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28090594/effects-of-tranexamic-acid-on-platelet-function-and-thrombin-generation-etaplat-woman-trial-sub-study
#15
Kastriot Dallaku, Haleema Shakur, Ian Roberts, Phil Edwards, Danielle Beaumont, Maria Delius, Braun Siegmund, Orion Gliozheni, Ilir Tasha, Saimir Cenameri, Ulrich Mansmann
Background. Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid (TXA) has the potential to reduce bleeding and a large randomized placebo controlled trial of its effect in women with PPH (The WOMAN trial) is underway. TXA might also affect coagulation factors and platelets.  Objectives. To examine the effect of TXA on thrombin generation, platelet function, fibrinogen, D-dimer and coagulation factors in women with PPH.  Methods. We will conduct a sub-study within the WOMAN trial...
December 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28088109/carbetocin-versus-oxytocin-for-prevention-of-post-partum-haemorrhage-at-caesarean-section-in-the-united-kingdom-an-economic-impact-analysis
#16
Helen A van der Nelson, Tim Draycott, Dimitrios Siassakos, Christopher W H Yau, Anthony J Hatswell
OBJECTIVE: To determine the economic impact of the introduction of carbetocin for the prevention of postpartum haemorrhage (PPH) at caesarean section, compared to oxytocin. STUDY DESIGN: The model is a decision tree conducted from a UK National Health Service perspective. 1500 caesarean sections (both elective and emergency) were modelled over a 12 month period. Efficacy data was taken from a published Cochrane meta-analysis, and costs from NHS Reference costs, the British National Formulary and the NHS electronic Medicines Information Tool...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28088108/hemostatic-effect-of-intrauterine-balloon-for-postpartum-hemorrhage-with-special-reference-to-concomitant-use-of-holding-the-cervix-procedure-matsubara
#17
Manabu Ogoyama, Hironori Takahashi, Rie Usui, Yosuke Baba, Hirotada Suzuki, Akihide Ohkuchi, Shigeki Matsubara
OBJECTIVE: The intrauterine balloon (Balloon) has recently been widely used to achieve hemostasis for postpartum hemorrhage (PPH). We concomitantly used a novel method, "holding the cervix", with the Balloon to prevent Balloon prolapse and achieve hemostasis. We aimed to clarify the following three factors: 1) hemostatic success rate of Balloon use for PPH, 2) effect of holding the cervix on Balloon prolapse, and, 3) the rate of bleeding after Balloon insertion, possibly predictive of Balloon failure...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28087319/biliary-fistula-after-pancreaticoduodenectomy-data-from-1618-consecutive-pancreaticoduodenectomies
#18
Stefano Andrianello, Giovanni Marchegiani, Giuseppe Malleo, Tommaso Pollini, Deborah Bonamini, Roberto Salvia, Claudio Bassi, Luca Landoni
BACKGROUND: Biliary fistula (BF) occurs in 3-8% of patients following pancreaticoduodenectomy (PD). It usually pursues a benign course, but rarely may represent a life-threatening event. STUDY DESIGN: Data from 1618 PDs were collected prospectively. BF was defined as the presence of bile stained fluid from drains by post-operative day 3 and confirmed by sinogram in the majority of cases. Three classifications were validated. RESULTS: BF occurred in 58 (3...
January 11, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28086822/assessment-of-quality-of-care-among-in-patients-with-postpartum-haemorrhage-and-severe-pre-eclampsia-at-st-francis-hospital-nsambya-a-criteria-based-audit
#19
Alfred Lumala, Peter Sekweyama, Andrew Abaasa, Humphrey Lwanga, Romano Byaruhanga
BACKGROUND: The maternal mortality ratio of Uganda is still high and the leading causes of maternal mortality are postpartum haemorrhage (PPH), severe pre-eclampsia and eclampsia. Criteria-based audit (CBA) is a way of improving quality of care that has not been commonly used in low income countries. This study aimed at finding out the quality of care provided to patients with these conditions and to find out if the implementation of recommendations from the audit cycle resulted in improvement in quality of care...
January 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28072700/is-prophylactic-tranexamic-acid-administration-effective-and-safe-for-postpartum-hemorrhage-prevention-a-systematic-review-and-meta-analysis
#20
REVIEW
Chunbo Li, Yuping Gong, Lingling Dong, Bingying Xie, Zhiyuan Dai
BACKGROUND: To assess the efficacy and safety of tranexamic acid (TA) in reducing blood loss and lowering transfusion needs for patients undergoing caesarean section (CS) or vaginal delivery (VD). METHODS: An electronic literature search of PubMed, EMBASE, OVID, Cochrane library, Scopus, Central, and Clinical trials.gov was performed to identify studies that evaluating the usage of TA in CS or VD. The methodological quality of included trials was assessed and data extraction was performed...
January 2017: Medicine (Baltimore)
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