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https://www.readbyqxmd.com/read/29047931/black-phosphorus-flakes-covered-microfiber-for-q-switched-ytterbium-doped-fiber-laser
#1
Ke-Xun Huang, Bao-Le Lu, Diao Li, Xin-Yuan Qi, Hao-Wei Chen, Na Wang, Zeng-Run Wen, Jin-Tao Bai
We demonstrate a passively Q-switched ytterbium-doped fiber laser based on black phosphorus (BP) flakes covered microfiber. The BP saturable absorber is fabricated by sandwiching a microfiber between two pieces of polydimethylsiloxane supported BP flakes film, which is prepared by the mechanical exfoliation method. In this case the BP flakes can be well protected from the action of air and moisture. By incorporating BP flakes covered microfiber into a ytterbium-doped ring fiber laser, stable and reliable Q-switched operation at 1064 nm can be realized via interaction between few-layers BP flakes and the evanescent field of the laser...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047400/observation-of-the-influences-of-diosgenin-on-aging-ovarian-reserve-and-function-in-a-mouse-model
#2
Mingjie Shen, Cong Qi, Yan-Ping Kuang, Yang Yang, Qi-Feng Lyu, Hui Long, Zhi-Guang Yan, Ying-Yu Lu
BACKGROUND: The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN: This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio group and were fed a single dose of diosgenin (200 mg/kg/day) suspended in 0.3% CMC. Twenty mice were assigned to the DHEA group and were fed a single dose of DHEA (1...
October 18, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29047106/extracellular-5-nucleotidase-cd73-promotes-human-breast-cancer-cells-growth-through-akt-gsk-3%C3%AE-%C3%AE-catenin-cyclind1-signaling-pathway
#3
Jiangang Yu, Xue Wang, Qi Lu, Jigang Wang, Luying Li, Xiaohong Liao, Wei Zhu, Lei Lv, Xiuling Zhi, Jerry Yu, Yiting Jin, Qiang Zou, Zhouluo Ou, Xiuping Liu, Ping Zhou
To identify the role and to explore the mechanism of extracellular 5'-nucleotidase (CD73) in human breast cancer growth, CD73 expression was measured firstly in breast cancer tissues and cell lines, and then interfered with or over-expressed by recombinant lentivirus in cell lines. Impacts of CD73 on breast cancer cell proliferation and cell cycle were investigated with colony formation assay, CCK-8 and flow cytometry. The relationship between CD73 and AKT/GSK-3β/β-catenin pathway was assessed with adenosine, adenosine 2A receptor antagonist (SCH-58261), adenosine 2A receptor agonist (NECA), CD73 enzyme inhibitor (APCP) and Akt inhibitor (MK-2206)...
October 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29046290/re-establishing-brain-networks-in-patients-with-esrd-after-successful-kidney-transplantation
#4
Hui Juan Chen, Jiqiu Wen, Rongfeng Qi, Jianhui Zhong, U Joseph Schoepf, Akos Varga-Szemes, Virginia W Lesslie, Xiang Kong, Yun Fei Wang, Qiang Xu, Zhe Zhang, Xue Li, Guang Ming Lu, Long Jiang Zhang
BACKGROUND AND OBJECTIVES: Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging...
October 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29043861/nasobiliary-drainage-can-reduce-the-incidence-of-post-ercp-pancreatitis-after-papillary-large-balloon-dilation-plus-endoscopic-biliary-sphincterotomy-a-randomized-controlled-trial
#5
Qiang Huang, Feng Shao, Chen Wang, Wei Qi, Lu Jun Qiu, Zheng Liu
BACKGROUND AND AIMS: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be reduced following endoscopic papillary balloon dilation with the placement of an endoscopic nasobiliary drainage (ENBD) catheter. The aim of this study was to determine whether the placement of an ENBD reduces the risk of post-ERCP pancreatitis following endoscopic papillary large balloon dilation together with endoscopic biliary sphincterotomy. METHODS: A total of 160 patients with bile duct stones were randomly assigned (1:1) to an ENBD group or no-ENBD group...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29042996/il-32%C3%AE-promotes-integrin-%C3%AE-v%C3%AE-6-expression-through-the-activation-of-nf-%C3%AE%C2%BAb-in-hscs
#6
Hongcan Liu, Xingfei Pan, Hong Cao, Xin Shu, Haixia Sun, Jianxi Lu, Jiayin Liang, Ka Zhang, Fengqin Zhu, Gang Li, Qi Zhang
Hepatic stellate cell (HSC) activation is important in the pathogenesis of liver fibrosis. However, the molecular mechanism of HSC activation is not completely understood. In the present study, it was demonstrated that interleukin-32γ (IL-32γ) is capable of enhancing intefgrin αvβ6 expression by inducing integrin αvβ6 promoter activity in a dose-dependent manner in HSCs. Furthermore, it was determined that nuclear factor κB (NF-κB) activation is required for IL-32γ-induced integrin αvβ6 expression...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040874/surface-functionalized-exosomes-as-targeted-drug-delivery-vehicles-for-cerebral-ischemia-therapy
#7
Tian Tian, Hui-Xin Zhang, Chun-Peng He, Song Fan, Yan-Liang Zhu, Cui Qi, Ning-Ping Huang, Zhong-Dang Xiao, Zu-Hong Lu, Bakhos A Tannous, Jun Gao
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been conjugated to the exosome surface by an easy, rapid, and bio-orthogonal chemistry...
October 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29040860/organics-removal-nitrogen-removal-and-n2o-emission-in-subsurface-wastewater-infiltration-systems-amended-with-without-biochar-and-sludge
#8
Yafei Sun, Shiyue Qi, Fanping Zheng, Linli Huang, Jing Pan, Yingying Jiang, Wanyuan Hou, Lu Xiao
Organics removal, nitrogen removal, N2O emission and nitrogen removal functional gene abundances in four subsurface wastewater infiltration systems (SWISs), named SWIS A (no intermittent aeration without biochar and sludge), SWIS B (no intermittent aeration with biochar and sludge), SWIS C (intermittent aeration without biochar and sludge), SWIS D (intermittent aeration with biochar and sludge) were investigated. Intermittent aeration enhanced chemical oxygen demand (COD), ammonia nitrogen (NH4(+)-N), total nitrogen (TN) removal and the abundances of nitrogen removal functional genes (amoA, nxrA, napA, narG, nirS, nirK, qnorB and nosZ) compared to non-aerated SWISs...
October 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040727/whole-genome-sequencing-of-african-dogs-provides-insights-into-adaptations-against-tropical-parasites
#9
Yan-Hu Liu, Lu Wang, Tao Xu, Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Hu Yang, Adeniyi C Adeola, Oscar J Sanke, Newton O Otecko, Meng Wang, Yaping Ma, Olaogun S Charles, Mikkel-Holger S Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J Hansen, Carlos Fernandes, Philippe Gaubert, Jane Budd, Philip M Dawuda, Eli Knispel Rueness, Lubin Jiang, Weiwei Zhai, M T P Gilbert, Min-Sheng Peng, Xiaopeng Qi, Guo-Dong Wang, Ya-Ping Zhang
Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion...
October 10, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29040359/a-rank-based-algorithm-of-differential-expression-analysis-for-small-cell-line-data-with-statistical-control
#10
Xiangyu Li, Hao Cai, Xianlong Wang, Lu Ao, You Guo, Jun He, Yunyan Gu, Lishuang Qi, Qingzhou Guan, Xu Lin, Zheng Guo
To detect differentially expressed genes (DEGs) in small-scale cell line experiments, usually with only two or three technical replicates for each state, the commonly used statistical methods such as significance analysis of microarrays (SAM), limma and RankProd (RP) lack statistical power, while the fold change method lacks any statistical control. In this study, we demonstrated that the within-sample relative expression orderings (REOs) of gene pairs were highly stable among technical replicates of a cell line but often widely disrupted after certain treatments such like gene knockdown, gene transfection and drug treatment...
October 13, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29038810/planarization-of-b20-clusters-by-si-and-c-atom-substitution
#11
Qi Liang Lu, Qi Quan Luo, Yi De Li, Shou Guo Huang
An optimization strategy combining a global semi-empirical quantum mechanical search and all-electron density functional theory was adopted to determine the lowest energy structures of B19Si and B19C clusters. The planarization of a B20 cluster by Si and C atom substitution was observed. The structural transition was from the double-ring tubular B20 to an almost perfect planar B19Si and a quasi-planar bowl B19C. B19Si possessed a geometry with a central B atom surrounded by a six-membered ring and a 13-atom outer ring...
October 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29035371/lncrna-mir100hg-derived-mir-100-and-mir-125b-mediate-cetuximab-resistance-via-wnt-%C3%AE-catenin-signaling
#12
Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L Franklin, Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee, Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan, Robert J Coffey
De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known genetic events linked to cetuximab resistance...
October 16, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29035305/nir-rapid-assessments-of-blumea-balsamifera-ai-na-xiang-in-china
#13
Fu-Lai Yu, Na Zhao, Zhi-Sheng Wu, Mei Huang, Dan Wang, Ying-Bo Zhang, Xuan Hu, Xiao-Lu Chen, Lu-Qi Huang, Yu-Xin Pang
Blumea balsamifera (Ai-na-xiang) is used as an important plant source of natural borneol, which is widely used in the pharmaceutical industry. The aim of this study was to establish the methods based on near infrared (NIR) spectroscopy for determining the geographical origin of B. balsamifera, as well as developing a method for the quantitative rapid analysis of the active pharmaceutical ingredients (APIs). A total of 109 samples were collected from China in 2013 and arbitrarily divided into calibration and prediction sets using the Kennard-Stone algorithm...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29034992/combined-prognostic-value-of-pretreatment-anemia-and-cervical-node-necrosis-in-patients-with-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy-a-large-scale-retrospective-study
#14
Lu-Lu Zhang, Guan-Qun Zhou, Yi-Yang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
This study investigated the combined prognostic value of pretreatment anemia and cervical node necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC). Retrospective review of 1302 patients with newly diagnosed nonmetastatic NPC treated with intensity-modulated radiotherapy (IMRT) ± chemotherapy. Patients were classified into four groups according to anemia and CNN status. Survival was compared using the log-rank test. Independent prognostic factors were identified using the Cox proportional hazards model...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29033840/hydrogen-sulfide-inhibits-cigarette-smoke-induced-endoplasmic-reticulum-stress-and-apoptosis-in-bronchial-epithelial-cells
#15
Fan Lin, Chengcheng Liao, Yun Sun, Jinsheng Zhang, Weiwei Lu, Yu Bai, Yixuan Liao, Minxia Li, Xianqiang Ni, Yuelong Hou, Yongfen Qi, Yahong Chen
Background: Apoptosis of lung structural cells contributes to the process of lung damage and remodeling in chronic obstructive pulmonary disease (COPD). Our previous studies demonstrated that exogenous hydrogen sulfide (H2S) can reduce the lung tissue pathology score, anti-inflammation and anti-oxidation effects in COPD, but the effect of H2S in regulating cigarette smoke (CS) induced bronchial epithelial cell apoptosis and the underlying mechanisms are not clear. Objectives: To investigate the effect of H2S on CS induced endoplasmic reticulum stress (ERS) and bronchial epithelial cell apoptosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033786/wnt5a-promotes-cortical-neuron-survival-by-inhibiting-cell-cycle-activation
#16
Li Zhou, Di Chen, Xu-Ming Huang, Fei Long, Hua Cai, Wen-Xia Yao, Zhong-Cheng Chen, Zhi-Jian Liao, Zhe-Zhi Deng, Sha Tan, Yi-Long Shan, Wei Cai, Yu-Ge Wang, Ri-Hong Yang, Nan Jiang, Tao Peng, Ming-Fan Hong, Zheng-Qi Lu
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis have not been determined. We find that Wnt5a acts as a mediator of cortical neuron survival, and Aβ42 promotes cortical neuron apoptosis by downregulating the expression of Wnt5a. Cell-cycle activation is mediated by the reduced inhibitory effect of Wnt5a in Aβ42 treated cortical neurons...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29032923/is-it-necessary-to-dissect-the-posterior-lymph-nodes-along-the-splenic-vessels-during-total-gastrectomy-with-d2-lymphadenectomy-for-advanced-gastric-cancer
#17
Jian-Xian Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin
BACKGROUND: D2 lymphadenectomy including No.10 lymph nodes (LNs) is the standard procedure for treating advanced gastric cancer (AGC) via total gastrectomy. However, there was no research focusing on the posterior LN dissection along the splenic vessels (No.10p LNs). This study is performed to assess the effect of dissecting No.10p LNs. METHODS: We analyzed 404 consecutive gastric cancer patients who underwent laparoscopic total gastrectomy (LTG) with D2 lymphadenectomy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29032163/massively-parallel-sequencing-on-human-cleavage-stage-embryos-to-detect-chromosomal-abnormality
#18
Zhi Zhou, Yanlin Ma, Qi Li, Yu Zhang, Yuanhua Huang, Zhihua Tu, Ning Ma, Minghong Li, Jun Wang, Jian Li, Weiying Lu
PURPOSE: Next-generation sequencing technology like MPS has recently been introduced to perform comprehensive chromosome screening on human trophectoderm samples for preimplantation embryo assessment. However, the potential of MPS in chromosome analysis of single cell from blastomeres has not yet been investigated. METHODS: In this study, 12 couples underwent MPS analysis, including 9 balanced translocation carriers and 3 carriers of numerical chromosomal abnormalities...
October 12, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29029394/long-non-coding-rna-h19-induces-hippocampal-neuronal-apoptosis-via-wnt-signaling-in-a-streptozotocin-induced-rat-model-of-diabetes-mellitus
#19
Yu-Hao Zhao, Tie-Feng Ji, Qi Luo, Jin-Lu Yu
Defects in hippocampal synaptic plasticity and disorders of memory and learning are the central nervous system complications of diabetes mellitus (DM). Here, we used a streptozotocin-induced rat DM model to investigate the effects of long non-coding RNA H19 (lncRNA H19) on learning and memory and apoptosis of hippocampal neurons, and the involvement of the Wnt signaling. Our data demonstrate that lncRNA H19 is highly expressed in rats with DM. Over-expression of lncRNA H19 increased positioning navigation latency in DM rats and decreased duration of space exploration...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028009/extended-polar-decomposition-method-of-mueller-matrices-for-turbid-media-in-reflection-geometry
#20
Ji Qi, Honghui He, Hui Ma, Daniel S Elson
The polar decomposition method for Mueller matrices proposed by Lu-Chipman has been demonstrated and validated for many applications. However, in some situations, e.g., when analyzing the Mueller matrix of birefringent turbid media with Mie-sized scatterers acquired in reflection geometry, the method may suffer from limitations due to the assumptions required by this method. Here we extend the Lu-Chipman method and show that it can provide more reasonable results for these situations. The method has been validated experimentally with turbid phantoms...
October 15, 2017: Optics Letters
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