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rheumatoid arthritis mimicking

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https://www.readbyqxmd.com/read/28331122/an-autopsy-case-report-of-adult-t-cell-leukemia-accompanied-by-rheumatoid-arthritis-mimicking-diffuse-panbronchiolitis
#1
Tomoko Shiraishi, Hiroshi Ishimoto, Kentaro Akata, Toshinori Kawanami, Kazuhiro Yatera, Hiroshi Mukae
A 50-year-old female with a history of chronic sinusitis and rheumatoid arthritis visited our department with repetitive lower respiratory tract infections of Pseudomonas aeruginosa. Her chest CT showed diffuse panbronchiolitis-like pulmonary lesions, her blood examination revealed atypical lymphocytes, and she was serologically positive for anti-human T-lymphotrophic virus type 1 (HTLV-1) antibody. Her rheumatoid arthritis had been well-controlled after biological agent treatment followed by anti-inflammatory analgesic treatment...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28323130/monocyte-activation-drives-preservation-of-membrane-thiols-by-promoting-release-of-oxidised-membrane-moieties-via-extracellular-vesicles
#2
K É Szabó-Taylor, E Á Tóth, A M Balogh, B W Sódar, L Kádár, K Pálóczi, N Fekete, A Németh, X Osteikoetxea, K V Vukman, M Holub, É Pállinger, Gy Nagy, P G Winyard, E I Buzás
The redox state of cellular exofacial molecules is reflected by the amount of available thiols. Furthermore, surface thiols can be considered as indicators of immune cell activation. One group of thiol containing proteins, peroxiredoxins, in particular, have been associated with inflammation. In this study, we assessed surface thiols of the U937 and Thp1 monocyte cell lines and primary monocytes in vitro upon inflammatory stimulation by irreversibly labelling the cells with a fluorescent derivative of maleimide...
March 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28274876/hypotonic-stress-promotes-atp-release-reactive-oxygen-species-production-and-cell-proliferation-via-trpv4-activation-in-rheumatoid-arthritis-rat-synovial-fibroblasts
#3
Fen Hu, Zhenhai Hui, Wei Wei, Jianyu Yang, Ziyuan Chen, Bu Guo, Fulin Xing, Xinzheng Zhang, Leiting Pan, Jingjun Xu
Rheumatoid arthritis (RA) is a chronic and systemic autoimmune-disease with complex and unclear etiology. Hypotonicity of synovial fluid is a typical characteristic of RA, which may play pivotal roles in RA pathogenesis. In this work, we studied the responses of RA synovial fibroblasts to hypotonic stress in vitro and further explored the underlying mechanisms. Data showed that hyposmotic solutions significantly triggered increases in cytosolic calcium concentration ([Ca(2+)]c) of synoviocytes. Subsequently, it caused rapid release of ATP, as well as remarkable production of intracellular reactive oxygen species (ROS)...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28169339/dna-methylation-governs-the-dynamic-regulation-of-inflammation-by-apoptotic-cells-during-efferocytosis
#4
Clare A Notley, Christine K Jordan, Jenny L McGovern, Mark A Brown, Michael R Ehrenstein
Efficient clearance of apoptotic cells (AC) is pivotal in preventing autoimmunity and is a potent immunosuppressive stimulus. However, activation of cells prior to apoptosis abolishes their immunoregulatory properties. Here we show using the antigen-induced model of arthritis that the degree of DNA methylation within AC confers their immunomodulatory plasticity. DNA isolated from resting and activated AC mimicked their respective immune effects. Demethylation of DNA abrogated the protective effect of AC whereas remethylation of AC DNA reversed the effects of activation and restored the ability to inhibit inflammation...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27974664/aggregatibacter-actinomycetemcomitans-induced-hypercitrullination-links-periodontal-infection-to-autoimmunity-in-rheumatoid-arthritis
#5
Maximilian F Konig, Loreto Abusleme, Jesper Reinholdt, Robert J Palmer, Ricardo P Teles, Kevon Sampson, Antony Rosen, Peter A Nigrovic, Jeremy Sokolove, Jon T Giles, Niki M Moutsopoulos, Felipe Andrade
A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites of disease initiation. The common occurrence of periodontal dysbiosis in RA suggests that oral pathogens may trigger the production of disease-specific autoantibodies and arthritis in susceptible individuals. We used mass spectrometry to define the microbial composition and antigenic repertoire of gingival crevicular fluid in patients with periodontal disease and healthy controls...
December 14, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27964706/low-dose-methotrexate-ld-mtx-in-rheumatology-practice-a-most-widely-misunderstood-drug
#6
REVIEW
Anand N Malaviya
Methotrexate (MTX) was synthesised as a folate antagonist for use in treating childhood leukaemia in 1940s. Gubner and colleagues in 1953 used several log-order lower doses of MTX that mimicked the anti-inflammatory properties of cortisone. They used it successfully in treating rheumatoid arthritis (RA). Their work was however overlooked because the Nobel Prize winning drug cortisone held sway in those days. With increasing awareness of the adverse effects of cortisone, interest was rekindled in discovering 'steroid-sparing' drugs...
2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27921239/cardiac-involvement-in-rheumatoid-arthritis-mimicking-sarcoidosis-on-fdg-pet-ct-and-mr-imaging
#7
Daniel Juneau, Joao R Inacio, Girish Dwivedi, Carole Dennie
No abstract text is available yet for this article.
December 5, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27882124/-5r-5-hydroxytriptolide-lldt-8-prevents-collagen-induced-arthritis-through-opg-rank-rankl-signaling-in-a-rat-model-of-rheumatoid-arthritis
#8
Ji-Zhou Zeng, Li-Feng Ma, Hai Meng, Hao-Miao Yu, Ya-Kui Zhang, Ai Guo
(5R)-5-hydroxytriptolide (LLDT-8) extracts from Tripterygium have anti-inflammatory, antineoplastic and immunity adjustment functions. The present study used a collagen-induced arthritis (CIA) model to evaluate whether LLDT-8 prevents collagen-induced arthritis, and investigated the signaling underlying this. Male Sprague-Dawley rats were induced to generate CIA, mimicking rheumatoid arthritis (RA). The presence of arthritis was determined using RA progression scores. The inflammatory cytokines interleukin (IL)-1β, IL-6 and nuclear factor-κB were detected using enzyme-linked immunosorbent assay kits...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27731553/clinical-spectrum-of-chikungunya-in-bikaner-north-western-india-in-2006-and-follow-up-of-patients-for-five-years
#9
L A Gauri, Ashok Thaned, Q Fatima, H Yadav, A Singh, H P Jaipal, A Chaudhary
OBJECTIVE: To find out clinical and laboratory profile of patients of chikungunya outbreak in 2006 in Bikaner (North-West Rajasthan) and follow up of chikungunya patients for 5 years. METHODS: Study was conducted among 50 chikungunya patients. For this study the inclusion criteria was clinical presentation consistent with chikungunya virus infection (e.g. abrupt onset of fever and/or polyarthralgia) and laboratory confirmation of chikungunya virus infection by IgM-capture ELISA...
March 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27419896/b-cell-lymphoma-mimicking-rheumatoid-arthritis
#10
M A Cosatti, C N Pisoni, J L Altuve, C Lorente
Non Hodking´s lymphoma (NHL) may involve bones but synovial involvement is uncommon. We describe a patient who presented with polyarthritis, sicca symptoms and rash suggestive of rheumatoid arthritis. An atypical skin rash prompted skin and synovial biopsies. A diagnosis of synovial and skin malignant large B-cell lymphoma anaplastic subtype was performed. Chemotherapy with dexamethasone, vincristine and rituximab was started. Following treatment the patient had complete resolution of cutaneous and articular lymphoma manifestations...
2016: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/27366177/rat-bite-fever-resembling-rheumatoid-arthritis
#11
Ripa Akter, Paul Boland, Peter Daley, Proton Rahman, Nayef Al Ghanim
Rat bite fever is rare in Western countries. It can be very difficult to diagnose as blood cultures are typically negative and a history of rodent exposure is often missed. Unless a high index of suspicion is maintained, the associated polyarthritis can be mistaken for rheumatoid arthritis. We report a case of culture-positive rat bite fever in a 46-year-old female presenting with fever and polyarthritis. The clinical presentation mimicked rheumatoid arthritis. Infection was complicated by discitis, a rare manifestation...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/27354158/mesenchymal-stem-cells-alleviate-experimental-rheumatoid-arthritis-through-microrna-regulated-i%C3%AE%C2%BAb-expression
#12
Xin Yan, Yurong Cen, Qin Wang
Previous studies have demonstrated that mesenchymal stem cell (MSC) transplantation reduces the severity of collagen-induced arthritis (CIA) in mice, which is a model for rheumatoid arthritis (RA) in humans. However, the underlying molecular mechanisms remain ill-defined. Here, we showed that MSC transplantation reduced the activities of NF-κB signaling and decreased microRNA-548e (miR-548e) levels in the joint tissue in CIA-mice, seemingly through activation of transforming growth factor β receptor signaling...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27118745/burning-vasculitis
#13
Priyanka Chadha, Dorian Hobday, Edmund Fitzgerald O'Connor, David D'Cruz
We present the case of a 69-year-old man who was found collapsed close to a heat source and admitted to hospital for severe sepsis. He was also found to have widespread blistering and ulceration of his right leg; however, a history was unobtainable due to reduced consciousness levels. The leg lesions had the initial appearance of mixed depth burns and a management plan was made to transfer the patient to a burns unit for debridement. It was subsequently noted that the patient had a previous diagnosis of seropositive erosive rheumatoid arthritis...
April 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26997007/postural-striatal-deformities-in-parkinson-s-disease-are-these-rare
#14
REVIEW
Sanjay Pandey, Hitesh Garg
Parkinson`s disease (PD) is the most common neurodegenerative disease and is characterized by tremor, rigidity and akinesia. Diagnosis is clinical in the majority of the patients. Patients with PD may have stooped posture but some of them develop different types of postural and striatal deformities. Usually these deformities are more common in atypical parkinsonian disorders such as progressive supranuclear palsy and multisystem atrophy. But in many studies it has been highlighted that these may also be present in approximately one third of PD patients leading to severe disability...
January 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/26909742/methotrexate-and-its-therapeutic-antagonists-caffeine-and-theophylline-target-a-motogenic-t-cell-mechanism-driven-by-thrombospondin-1-tsp-1
#15
Toomas Talme, Eva Bergdahl, Karl-Gösta Sundqvist
Methotrexate (MTX) is a widely used treatment for inflammatory diseases such as rheumatoid arthritis and psoriasis, based on the concept that it is immunosuppressive. Its mechanism of action, however, remains unclear, although it is thought to depend on adenosine. Caffeine and theophylline, which have several targets including adenosine receptors, have been shown to suppress the beneficial clinical effects of MTX. Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1)...
May 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26886813/rampant-infections-of-bone-marrow-stem-cell-niches-as-triggers-for-spondyloarthropathies-and-rheumatoid-arthritis
#16
REVIEW
Jean-Marie Berthelot, Jean Sibilia
Tropheryma Whipplei can induce rheumatism mimicking SpA or RA, but even more rampant bacterial/viral infections in epiphyseal bones could also contribute to the onset of RA and SpA. Indeed, as bone marrow stem cell niches are enriched in Tregs and myeloid derived suppressor cells, these areas are favourable for the persistence of quiescent viruses and/or dormant bacteria. This review focuses on the possibility that such silent infections of bone marrow stem cell niches might contribute to the pathogenesis of SpA and RA, at least during their onset...
March 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26848119/granulocyte-colony-stimulating-factor-g-csf-plays-an-important-role-in-immune-complex-mediated-arthritis
#17
Anne D Christensen, Claus Haase, Andrew D Cook, John A Hamilton
Neutrophils are an abundant cell type in many chronic inflammatory diseases such as rheumatoid arthritis (RA); however, their contribution to the pathology of RA has not been widely studied. A key cytokine involved in neutrophil development and function is granulocyte-colony stimulating factor (G-CSF). In this study we used the K/BxN serum-transfer arthritis (STA) model, mimicking the effector phase of RA, to investigate the importance of G-CSF in arthritis development and its relation to neutrophils. Here, we show for the first time in this model that G-CSF levels are increased both in the serum and in inflamed paws of arthritic mice and importantly that G-CSF blockade leads to a profound reduction in arthritis severity, as well as reduced numbers of neutrophils in blood...
May 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26834222/assessment-of-the-new-2012-eular-acr-clinical-classification-criteria-for-polymyalgia-rheumatica-a-prospective-multicenter-study
#18
Gulsen Ozen, Nevsun Inanc, Ali Ugur Unal, Seda Bas, Gezmis Kimyon, Bunyamin Kisacik, Ahmet Mesut Onat, Sadiye Murat, Havva Keskin, Meryem Can, Alperen Mengi, Necati Cakir, Ayse Balkarli, Veli Cobankara, Neslihan Yilmaz, Ayten Yazici, Atalay Dogru, Mehmet Sahin, Ali Sahin, Kevser Gok, Soner Senel, Omer Nuri Pamuk, Sema Yilmaz, Ozun Bayindir, Kenan Aksu, Yonca Cagatay, Lutfi Akyol, Mehmet Sayarlioglu, Gozde Yildirim-Cetin, Sule Yasar-Bilge, Ilker Yagci, Sibel Zehra Aydin, Fatma Alibaz-Oner, Pamir Atagunduz, Haner Direskeneli
OBJECTIVE: To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study. METHODS: Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR...
May 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26783440/poncet-s-disease-mimicking-rheumatoid-arthritis-in-a-patient-with-suspected-crohn-s-disease
#19
Miguel Ariza-Prota, Ana Pando-Sandoval, Marta García-Clemente, Pere Casan
Poncet's disease is a rarely reported entity with an unknown pathogenesis. However, because it has a very favorable prognosis with antituberculosis drugs, we believe it should be considered as a differential diagnosis for patients with fever and polyarthritis of unknown cause, particularly if active tuberculosis is suspected.
January 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/26651929/-mycobacterium-avium-tumoral-infection-mimicking-a-lung-adenocarcinoma-a-potential-diagnostic-pitfall
#20
A A Fiogbe, G Liistro, D Hoton, T Pieters
INTRODUCTION: The incidence of atypical mycobacterial infection in Europe is estimated at one case per 100,000 persons/year. Despite the low incidence of Mycobacterium avium infection, it can result in a nodular lesion simulating lung cancer. We report a case of atypical mycobacteriosis, mimicking lung cancer, which led to a lobectomy. CASE REPORT: It was a right pulmonary upper lobe nodule found in a 63-year-old COPD patient, partially nephrectomized for renal carcinoma, and weekly treated by methotrexate for rheumatoid arthritis...
April 2016: Revue de Pneumologie Clinique
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