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https://www.readbyqxmd.com/read/28429623/schema-therapy-for-personality-disorders-in-older-adults-a-multiple-baseline-study
#1
Arjan C Videler, Sebastiaan P J van Alphen, Rita J J van Royen, Christina M van der Feltz-Cornelis, Gina Rossi, Arnoud Arntz
OBJECTIVE: No studies have been conducted yet into the effectiveness of treatment of personality disorders in later life. This study is a first test of the effectiveness of schema therapy for personality disorders in older adults. METHOD: Multiple-baseline design with eight cluster C personality disorder patients, with a mean age of   69. After a baseline phase with random length, schema therapy was given during the first year, followed by follow-up sessions during six months...
April 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28428048/multi-center-machine-learning-in-imaging-psychiatry-a-meta-model-approach
#2
Petr Dluhoš, Daniel Schwarz, Wiepke Cahn, Neeltje van Haren, René Kahn, Filip Španiel, Jiří Horáček, Tomáš Kašpárek, Hugo Schnack
One of the biggest problems in automated diagnosis of psychiatric disorders from medical images is the lack of sufficiently large samples for training. Sample size is especially important in the case of highly heterogeneous disorders such as schizophrenia, where machine learning models built on relatively low numbers of subjects may suffer from poor generalizability. Via multicenter studies and consortium initiatives researchers have tried to solve this problem by combining data sets from multiple sites. The necessary sharing of (raw) data is, however, often hindered by legal and ethical issues...
April 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28427332/interrater-and-test-retest-reliability-and-validity-of-the-norwegian-version-of-the-bestest-and-mini-bestest-in-people-with-increased-risk-of-falling
#3
Charlotta Hamre, Pernille Botolfsen, Gro Gujord Tangen, Jorunn L Helbostad
BACKGROUND: The Balance Evaluation Systems Test (BESTest) was developed to assess underlying systems for balance control in order to be able to individually tailor rehabilitation interventions to people with balance disorders. A short form, the Mini-BESTest, was developed as a screening test. The study aimed to assess interrater and test-retest reliability of the Norwegian version of the BESTest and the Mini-BESTest in community-dwelling people with increased risk of falling and to assess concurrent validity with the Fall Efficacy Scale-International (FES-I), and it was an observational study with a cross-sectional design...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28424654/emerging-approaches-for-validating-and-managing-multiple-sclerosis-relapse
#4
REVIEW
Elizabeth A Mills, Ali Mirza, Yang Mao-Draayer
The autoimmune disease multiple sclerosis (MS) is characterized by relapses in the majority of patients. A definitive clinical diagnosis of relapse in MS can be complicated by the presence of an infection or comorbid disorder. In this mini-review, we describe efforts to develop enhanced imaging techniques and biomarker detection as future tools for relapse validation. There is emerging evidence of roles for meningeal inflammation, sex hormones, comorbid metabolic or mood disorders, and a dysregulated immune profile in the manifestation and severity of relapse...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28423058/accurate-phenotyping-reconciling-approaches-through-bayesian-model-averaging
#5
Carla Chia-Ming Chen, Jonathan Macgregor Keith, Kerrie Lee Mengersen
Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understanding the genetic composition of the diseases. Various statistical approaches have been proposed for phenotype definition; however our previous studies have shown that differences in phenotypes estimated using different approaches have substantial impact on subsequent analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28421867/symptom-related-attributional-biases-in-schizophrenia-and-bipolar-disorder
#6
Nicole Sanford, Todd S Woodward
INTRODUCTION: Biases in causal attributions and evidence integration have been implicated in delusions, but have not been investigated simultaneously to examine additive or multiplicative effects. It was hypothesised that paranoid delusions would correlate with self-serving and personalising biases ("defence" model of paranoia), particularly when these biases were disconfirmed. METHODS: Constrained principal component analysis was used to investigate differences between schizophrenia patients (paranoid vs...
April 19, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28410607/aprecisekure-an-approach-of-precision-medicine-in-a-rare-disease
#7
Ottavia Spiga, Vittoria Cicaloni, Andrea Bernini, Andrea Zatkova, Annalisa Santucci
BACKGROUND: Alkaptonuria (AKU; OMIM:203500) is a classic Mendelian genetic disorder described by Garrod already in 1902. It causes urine to turn black upon exposure to air and also leads to ochronosis as well as early osteoarthritis. Our objective is the implementation of a Precision Medicine (PM) approach to AKU. We present here a novel ApreciseKUre database facilitating the collection, integration and analysis of patient data in order to create an AKU-dedicated "PM Ecosystem" in which genetic, biochemical and clinical resources can be shared among registered researchers...
April 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28406663/neuropsychological-correlates-of-theory-of-mind-deficits-in-patients-with-multiple-sclerosis
#8
Simona Raimo, Luigi Trojano, Simona Pappacena, Raffaella Alaia, Daniele Spitaleri, Dario Grossi, Gabriella Santangelo
BACKGROUND: Theory of mind (ToM) is the ability to understand and interpret another person's beliefs, intentions (cognitive ToM) and emotions (affective ToM). OBJECTIVE: To explore affective and cognitive ToM and their neuropsychological correlates in patients affected by multiple sclerosis (MS). MATERIAL AND METHOD: Forty MS patients and 40 matched control individuals underwent tasks assessing cognitive (the ToM Pictures Sequencing Task and the Advanced Test of ToM) and affective ToM (the Reading the Mind in the Eyes Task and the Emotion Attribution Task), in both verbal and nonverbal modality, a comprehensive neuropsychological battery, and questionnaires for behavioral disorders...
April 13, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28406266/the-3-year-course-of-multiple-substance-use-disorders-in-the-united-states-a-national-longitudinal-study
#9
Sean Esteban McCabe, Brady T West
OBJECTIVE: To examine the 3-year course of multiple co-occurring substance use disorders (SUDs) based on longitudinal survey data from a large, nationally representative sample. METHODS: National estimates of the prevalence of DSM-IV SUDs were derived by analyzing data from structured, face-to-face diagnostic interviews as part of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), which collected data from a large, nationally representative sample of noninstitutionalized US adults at 2 waves (2001-2002 and 2004-2005; N = 34,653)...
April 11, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28403981/management-of-the-multiple-symptoms-of-irritable-bowel-syndrome
#10
REVIEW
Magnus Simrén, Hans Törnblom, Olafur S Palsson, William E Whitehead
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. A stepwise management approach is advocated for patients with IBS. For a substantial proportion of patients with mild symptoms, general management principles, including making a confident diagnosis and offering explanation, reassurance, and dietary and lifestyle advice, are sufficient. However, many patients continue to have moderate-to-severe symptoms and are not satisfied solely with this approach. In these patients, use of pharmacotherapy on the basis of the predominant symptom (constipation, diarrhoea, pain, or bloating) or combination of symptoms is the next step...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403587/tadalafil-once-daily-narrative-review-of-a-treatment-option-for-female-sexual-dysfunctions-fsd-in-midlife-and-older-women
#11
Chiara Borghi, Lucio Dell'Atti
Female Sexual Disorders (FSD) include a complex, multidimensional, individual experience that can change as an individual age, suggesting that these problems are caused by multiple factors including psychosocial factors, personal relationships, pathologic changes caused by diseases, and pharmacologic influences. Menopause is an important time for middle aged women and postmenopausal physiological changes could have a significant role in the development of FSD. Few is still known about their correct definition and treatment...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28398986/living-with-symptoms-of-attention-deficit-hyperactivity-disorder-in-adulthood-a-systematic-review-of-qualitative-evidence
#12
Merete B Bjerrum, Preben U Pedersen, Palle Larsen
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) relates to four dimensions of behavior: inattentiveness, restlessness, impulsiveness and hyperactivity. Symptoms affect multiple areas of daily life such as academic performance and social functioning. Despite the negative effects of ADHD, people diagnosed with ADHD do not necessarily regard themselves as being impaired. However, it is unclear how adults with ADHD experience and manage their symptoms. OBJECTIVES: To identify and synthesize the best available evidence on how adults experience living with ADHD...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28395207/brief-cognitive-behavioral-therapy-for-insomnia-delivered-to-depressed-veterans-receiving-primary-care-services-a-pilot-study
#13
Wilfred R Pigeon, Jennifer Funderburk, Todd M Bishop, Hugh F Crean
BACKGROUND: Depression and insomnia are treatable, often co-occur and are common among primary care patients. Treatments designed for primary care must be brief, effective and ideally have the potential to address multiple symptoms. A brief form of cognitive behavioral therapy for insomnia (CBT-I) was piloted among depressed primary care patients with insomnia some of whom endorsed suicidal ideation. METHODS: Veterans Affairs primary care patients were randomized to either CBT-I or sleep hygiene...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28394031/degeneration-of-rapid-eye-movement-sleep-circuitry-underlies-rapid-eye-movement-sleep-behavior-disorder
#14
REVIEW
Dillon McKenna, John Peever
During healthy rapid eye movement sleep, skeletal muscles are actively forced into a state of motor paralysis. However, in rapid eye movement sleep behavior disorder-a relatively common neurological disorder-this natural process is lost. A lack of motor paralysis (atonia) in rapid eye movement sleep behavior disorder allows individuals to actively move, which at times can be excessive and violent. At first glance this may sound harmless, but it is not because rapid eye movement sleep behavior disorder patients frequently injure themselves or the person they sleep with...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28390442/a-first-step-toward-integrating-schema-theory-in-geriatric-psychiatry-a-delphi-study
#15
M J H Legra, F R J Verhey, S P J van Alphen
BACKGROUND: Schematherapy (ST) is an effective therapy for personality disorders (PD's) in adults, however, empirical research into ST in older adults is limited. The manifestation of schemas over the life course is unclear. Besides, long-term patterns of schemas in old age and whether schemas change during the aging process remain unknown. METHODS: We performed a Delphi study involving a group meeting of nine experts in the field of ST in older adults. RESULTS: Full consensus was achieved that schemas vary later in life, and that this is due to biopsychosocial factors...
April 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28390399/could-a-short-training-intervention-modify-opinions-about-mental-illness-a-case-study-on-french-health-professionals
#16
Murielle Villani, Viviane Kovess-Masfety
BACKGROUND: In France, negative views on schizophrenia are pervasive, even among health professionals. Prior research suggests that the level of prejudice is lower when the illness is described with the example of a specific individual. This finding highlights the importance of designing local, targeted destigmatization campaigns. The present study aims to evaluate the benefits of a short intervention offering contact with psychiatric services users on reducing the stigma about mentally ill people, among a sample of Health Administrators and Students...
April 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28381420/continuum-beliefs-and-stigmatising-beliefs-about-mental-illness-results-from-an-asian-community-survey
#17
Mythily Subramaniam, Edimansyah Abdin, Louisa Picco, Shazana Shahwan, Anitha Jeyagurunathan, Janhavi Ajit Vaingankar, Siow Ann Chong
OBJECTIVES: To establish the prevalence and correlates of continuum beliefs for five mental illnesses in a multiethnic population and to explore its association with stigma. DESIGN: A community-based, cross-sectional study. SETTING: A national study in a multiethnic Asian country. PARTICIPANTS: A comprehensive study of 3006 Singapore residents (Singapore citizens and permanent residents) aged 18-65 years who were living in Singapore at the time of the survey...
April 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28380063/type-d-personality-and-post-traumatic-stress-disorder-symptoms-among-intensive-care-unit-nurses-the-mediating-effect-of-resilience
#18
Geum-Jin Cho, Jiyeon Kang
The purpose of this study was to investigate the relationship between Type D personality and post-traumatic stress disorder (PTSD) symptoms of intensive care unit (ICU) nurses and to determine the mediating effect of resilience on this relationship. A cross-sectional survey was performed with 179 ICU nurses from 7 hospitals in Gyeong-Nam province, South Korea. The Type D personality, resilience, and PTSD symptoms of subjects were measured using a self-report questionnaire. The mediating effect was analyzed by a series of hierarchical multiple regressions...
2017: PloS One
https://www.readbyqxmd.com/read/28377808/the-outcomes-of-home-treatment-for-borderline-personality-disorder
#19
Sibel Turhan, Mark Taylor
Aims and method There is currently no trial or other scientific evidence informing the efficacy of any crisis intervention for people with borderline personality disorder (BPD). We aimed to assess the patterns of service use by patients with BPD taken on for crisis resolution and home treatment between 2010 and 2013. Patients with a diagnosis of BPD were identified and demographic and clinical data were collected. Results All patients were female, and a high proportion had recurrent presentations to crisis and home treatment services in Edinburgh...
December 2016: BJPsych Bulletin
https://www.readbyqxmd.com/read/28377012/mental-disorders-in-people-affected-by-thalidomide
#20
Alexander Niecke, Klaus Peters, Christina Samel, Kristin Forster, Markus Lüngen, Holger Pfaff, Christian Albus
BACKGROUND: More than 50 years after the withdrawal of thalidomide from the market, subsequent orthopedic damages and psychosocial impairments dominate the complaints of thalidomide-affected individuals. The aim of the study was to determine the prevalence of mental disorders in this group. METHODS: A total of 193 thalidomide-affected individuals from North Rhine-Westphalia (mean age 50.5 years, 56.5% women) underwent personal and comprehensive psychodiagnostic testing, which was based on the Structured Clinical Interview for DSM-IV disorders (SCID-I & SCID-II) and self-reporting questionnaires...
March 10, 2017: Deutsches Ärzteblatt International
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