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Gallbladder dyskinesia

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https://www.readbyqxmd.com/read/27521713/gallbladder-disease-in-children
#1
David H Rothstein, Carroll M Harmon
Biliary disease in children has changed over the past few decades, with a marked rise in incidence-perhaps most related to the parallel rise in pediatric obesity-as well as a rise in cholecystectomy rates. In addition to stone disease (cholelithiasis), acalculous causes of gallbladder pain such as biliary dyskinesia, also appear to be on the rise and present diagnostic and treatment conundrums to surgeons.
August 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27472474/biliary-dyskinesia-in-children-a-systematic-review
#2
Neha Santucci, Sunny Z Hussain, Carroll M Harmon, Julie H Schiavo, Paul E Hyman
OBJECTIVES: Cholecystectomy rates for biliary dyskinesia in children are rising in the United States, but not in other countries. Biliary dyskinesia is a validated functional gallbladder disorder in adults, requiring biliary colic in the diagnosis. In contrast, most studies in children require upper abdominal pain, absent gallstones on ultrasound and an abnormal gallbladder ejection fraction (GBEF) on cholecystokinin-stimulated cholescintigraphy for diagnosis. We aimed to systematically review existing literature in biliary dyskinesia in children, determine the validity and reliability of diagnostic criteria, GBEF, and to assess outcomes following cholecystectomy...
July 28, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27158759/cystoisospora-belli-infection-of-the-gallbladder-in-immunocompetent-patients-a-clinicopathologic-review-of-18-cases
#3
Keith K Lai, Hannah E Goyne, David Hernandez-Gonzalo, Kennon A Miller, Marion Tuohy, Gary W Procop, Laura W Lamps, Deepa T Patil
Cystoisospora belli, previously known as Isospora belli, is an obligate intracellular coccidian parasite that is most often associated with gastrointestinal disease in immunocompromised patients. In this study, we detail the clinicopathologic features of 18 cases of Cystoisospora infection affecting the gallbladder in immunocompetent individuals and compare them with a control group. Each case was reviewed for cholecystitis (none, acute, chronic), epithelial disarray, presence of intraepithelial lymphocytes (none, rare [≤5 per 20 epithelial cells], present [>5 per 20 epithelial cells]), architectural distortion, intramucosal eosinophilia, and mural thickening/serositis...
August 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27049778/pilot-randomized-controlled-trial-of-laparoscopic-cholecystectomy-vs-active-nonoperative-therapy-for-the-treatment-of%C3%A2-biliary%C3%A2-dyskinesia
#4
Bryan K Richmond, Caresse Grodman, Jerri Walker, Scott Dean, Edward H Tiley, Roland E Hamrick, Kristen Statler, Mary Emmett
BACKGROUND: Despite widespread adoption by the surgical community, high-quality prospective data supporting the practice of laparoscopic cholecystectomy (LC) for the treatment of biliary dyskinesia (BD) are lacking. STUDY DESIGN: Adult patients meeting criteria for diagnosis of BD (Rome III symptoms, normal ultrasound, gallbladder ejection fraction < 38%) were randomized to either LC or a trial of nonoperative (NO) therapy with a low-dose neuromodulator (amitriptyline 25 mg/day)...
June 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26409755/implications-of-gallbladder-cholesterolosis-and-cholesterol-polyps
#5
Saif Dairi, Andrew Demeusy, Anne M Sill, Shirali T Patel, Gopal C Kowdley, Steven C Cunningham
BACKGROUND: The clinical significance of cholesterolosis has not been well established but there are some provocative, if not robust, studies of the role it may play in the pathophysiology of pancreatitis and biliary dyskinesia, as well as hypercholesterolemia. Our aim was to take advantage of a very large cholecystectomy (CCY) database to support or refute these potentially important reported associations. MATERIALS AND METHODS: A retrospective review of 6868 patients who underwent CCY from 2001-2013 was performed...
February 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26140885/hida-scan-with-ejection-fraction-is-over-utilized-in-the-management-of-biliary-dyskinesia
#6
Amanda H Eckenrode, Joseph A Ewing, Jennifer Kotrady, Allyson L Hale, Dane E Smith
Patients with upper abdominal pain, nausea, and vomiting are often evaluated with ultrasound to diagnose symptomatic cholelithiasis or cholecystitis. With a normal ultrasound, a hepatobiliary iminodiacetic acid (HIDA) scan with ejection fraction (EF) is recommended to evaluate gallbladder function. The purpose of this study was to evaluate whether the HIDA scan with EF was appropriately utilized in considering cholecystectomy. Over 18 months, we performed 1533 HIDA scans with EF. After exclusion, 1501 were analyzable, 438 of whom underwent laparoscopic cholecystectomy...
July 2015: American Surgeon
https://www.readbyqxmd.com/read/26065551/chronic-cholecystitis-with-cystoisospora-belli-in-an-immunocompetent-patient
#7
Hideo Takahashi, Gavin A Falk, Michael Cruise, Gareth Morris-Stiff
A 47-year-old woman presented with a history of vague abdominal pain for several years, which worsened over the past 2 months, with pain more prominent in the right upper quadrant. She also had a history of peptic ulcer disease. The ultrasound scan of right upper quadrant revealed normal gallbladder and oesophagogastroduodenoscopy was unremarkable. A (99m)technetium labelled hepato iminodiacetic acid (HIDA) scan with cholecystokinin provocation demonstrated a decreased gallbladder ejection fraction (EF) of 32%...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/25761535/suprahepatic-gallbladder
#8
REVIEW
Jacob A Hessey, Laura Halpin, Kerri A Simo
INTRODUCTION: Suprahepatic gallbladders have been reported in the literature dating back to 1965. However, their etiology and consequences remain unclear. METHODS: A case of a patient being treated for biliary dyskinesia with an incidental finding of suprahepatic gallbladder is presented along with a literature review on the causes, effects, and management of a suprahepatic gallbladder. DISCUSSION: Patient underwent a robotic-assisted laparoscopic cholecystectomy without complications and had an uneventful recovery...
July 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/25588803/management-of-gallbladder-dyskinesia-patient-outcomes-following-positive-%C3%A2-%C3%A2-mtechnetium-tc-labelled-hepatic-iminodiacetic-acid-hida-scintigraphy-with-cholecystokinin-cck-provocation-and-laparoscopic-cholecystectomy
#9
R V Dave, S Pathak, A J Cockbain, J P Lodge, A M Smith, F U Chowdhury, G J Toogood
AIMS: To evaluate clinical outcomes in patients with typical biliary pain, normal ultrasonic findings, and a positive (99m)technetium (Tc)-labelled hepatic iminodiacetic acid analogue (HIDA) scintigraphy with cholecystokinin (CCK) provocation indicating gallbladder dyskinesia, as per Rome III criteria, undergoing laparoscopic cholecystectomy (LC). METHODS AND MATERIALS: Consecutive patients undergoing LC for gallbladder dyskinesia were identified retrospectively...
April 2015: Clinical Radiology
https://www.readbyqxmd.com/read/25502153/cholecystectomy-for-biliary-dyskinesia-in-gastroparesis-mimic-or-misfortune
#10
Salman Nusrat, Sultan Mahmood, Donald Kastens, Klaus Bielefeldt
OBJECTIVES: Biliary dyskinesia and gastroparesis are associated with upper abdominal discomfort and dyspeptic symptoms in the absence of structural abnormalities. We hypothesized that the similarity in symptoms would trigger testing and surgical treatment for biliary abnormalities in a significant number of patients, with refractory symptoms ultimately demonstrating impairment of gastric function. METHODS: The study was designed as a retrospective review of patients seen between April 1, 2008 and December 31, 2009...
December 2014: Southern Medical Journal
https://www.readbyqxmd.com/read/25457533/hepatobiliary-phase-of-gadoxetic-acid-enhanced-mr-in-patients-suspected-of-having-gallbladder-dyskinesia-comparison-with-hepatobiliary-scintigraphy
#11
COMPARATIVE STUDY
Jeong Kyong Lee, Yookyung Kim, Sangmin Lee, Ji Eun Park
OBJECTIVE: To compare hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (HMR) and hepatobiliary scintigraphy (HBS) for evaluation of cystic duct patency and gallbladder contractility in patients suspected of having gallbladder dyskinesia. MATERIALS AND METHODS: Eighteen patients underwent HMR and HBS. Cystic duct patency and gallbladder ejection fraction (GBEF) were compared to determine a significant difference between HMR and HBS. RESULTS: HMR and HBS had 15 concordant and 3 discordant results for cystic duct patency...
January 2015: Clinical Imaging
https://www.readbyqxmd.com/read/25366951/the-therapeutic-activity-of-sulphate-bicarbonate-calcium-magnesiac-mineral-water-in-the-functional-disorders-of-the-biliary-tract
#12
G Mennuni, L Petraccia, M Fontana, S Nocchi, E Stortini, M Romoli, E Esposito, F Priori, M Grassi, A Geraci, A Serio, A Fraioli
BACKGROUND AND AIM: Functional disorders of the biliary tract involve gallbladder and sphincter of Oddi and cause pain and/or digestive troubles. In this context, in addition to pharmacological treatments, an important role is played by the use of sodium-sulphate and sulphate-bicarbonate mineral waters that, because of their composition into ions macro and trace elements, can stimulate the release or modulate the activity of some neurohumoral regulators of the digestive process. We want to do a study on the effects of hydropinotherapy with a sulphate-bicarbonate-calcium-magnesium mineral water in patients suffering from pain and other symptoms caused by biliary dyskinesias, biliary sand (without gallstones), or following a cholecystectomy (post-cholecystectomy syndromes)...
2014: La Clinica Terapeutica
https://www.readbyqxmd.com/read/25354374/successful-treatment-of-gallbladder-dyskinesia-by-laparascopic-cholecystectomy-report-of-a-case
#13
Takamitsu Sasaki, Daisuke Kato, Satoshi Shinya, Ryo Nakashima, Hironari Shiwaku, Kanefumi Yamashita, Yuichi Yamashita
A 75-year-old woman entered the hospital emergency room complaining of severe epigastric pain. She had experienced similar repeated abdominal pain for some time. Biliary tract dyskinesia was suspected based on the Roma III criteria. When drip infusion cholangiography-CT with egg yolk load was performed, the contraction rate of the gallbladder before and after applying the load was as low as 33.5%. Upon biliary tract scintigraphy, biliary excretion into the intestinal tract was found to be normal, but after the egg yolk load, the biliary excretion rate in the gallbladder decreased to 14...
November 2014: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/25278145/gallbladder-dysfunction-how-much-longer-will-it-be-controversial
#14
REVIEW
Naeem Goussous, Gopal C Kowdley, Neeraj Sardana, Ethan Spiegler, Steven C Cunningham
BACKGROUND: Motility disorders of the biliary tree [biliary dyskinesia, including both gallbladder dysfunction (GBD), and sphincter of Oddi dysfunction] are difficult to diagnose and to treat. SUMMARY: There is controversy in the literature in particular regarding the criteria that should be used to select patients for cholecystectomy (CCY) in cases of suspected GBD. The current review covers the history, diagnosis, and treatment of GBD. Key Messages: Only >85% of patients with suspected GBD have relief following CCY, a much lower rate than the nearly 100% success rate following CCY for gallstone disease...
2014: Digestion
https://www.readbyqxmd.com/read/25193389/cholecystectomy-for-biliary-dyskinesia-how-did-we-get-there
#15
REVIEW
Klaus Bielefeldt, Shreyas Saligram, Susan L Zickmund, Anwar Dudekula, Mojtaba Olyaee, Dhiraj Yadav
BACKGROUND: The focus of biliary dyskinesia (BD) shifted within the last 30 years, moving from symptoms after cholecystectomy (CCY) to symptoms with morphological normal gallbladder, but low gallbladder ejection fraction. METHODS: We searched the pubmed database to systematically review studies focusing on the diagnosis and treatment of gallbladder dysfunction. RESULTS: Impaired gallbladder contraction can be found in about 20% of healthy controls and an even higher number of patients with various other disorders...
December 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24942262/twenty-years-of-surveillance-in-rett-syndrome-what-does-this-tell-us
#16
Alison Anderson, Kingsley Wong, Peter Jacoby, Jenny Downs, Helen Leonard
BACKGROUND: The clinical characteristics of children diagnosed with Rett syndrome are well described. Survival and how these characteristics persist or change in adulthood are less well documented. This study aimed to describe overall survival and adult health in those with Rett syndrome. METHODS: Using the Kaplan-Meier method, we estimated survival of individuals registered with the Australian Rett syndrome Database (ARSD) who had been followed for up to 20 years (n = 396)...
2014: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/24874936/acalculous-cholecystitis-or-biliary-dyskinesia-for-epstein-barr-virus-gallbladder-involvement
#17
Andrew Fretzayas, Maria Moustaki, Achilleas Attilakos, Triantafillia Brozou, Polyxeni Nicolaidou
We present two patients with Epstein-Barr virus (EBV) infection related to gallbladder involvement. Such an association is already known as EBV induced acalculous cholecystitis, diagnosed on the basis of ultrasonographic findings. In our patients, radioisotopic cholescintigraphy was also performed and it showed that gallbladder was visualized in both patients in contrast to that what can be observed in cases of cholecystitis. However, the value of ejection fraction was compatible with biliary dyskinesia. We, therefore, consider that impaired gallbladder contractility in EBV infection cases may actually represent biliary dyskinesia and not acalculous cholecystitis taking into account the radioisotopic findings and the self limited course of the disorder...
2014: Prague Medical Report
https://www.readbyqxmd.com/read/24852884/pain-provocation-and-low-gallbladder-ejection-fraction-with-cck-cholescintigraphy-are-not-predictive-of-chronic-acalculous-gallbladder-disease-symptom-relief-after-cholecystectomy
#18
Michael A Edwards, Benjamin Mullenbach, Sherman M Chamberlain
INTRODUCTION: Chronic acalculous gallbladder disease (CAGD) falls within the spectrum of diseases associated with gallbladder dysmotility. Cholecystokinin-cholescintigraphy (CCK-CS) has been used to evaluate for CAGD, with a gallbladder ejection fraction (GBEF) of <35 % being indicative of gallbladder dysfunction. The reproduction of biliary colic upon administration of CCK has been cited as indicative of CAGD. Our purpose was to determine whether low GBEF or reproduction of pain during CCK-CS was predictor of surgical outcomes related to resolution of symptoms or as a correlate to gallbladder pathology...
November 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24726126/cholecystectomy-in-danish-children-a-nationwide-study
#19
Karen Oline Langballe, Linda Bardram
BACKGROUND: An increase in the frequency of cholecystectomy in children has been described during the last decades. Part of the reason is that more cholecystectomies in children are performed for dyskinesia of the gallbladder and not only for gallstone disease. We conducted the first nationwide study to describe outcome of cholecystectomies performed in children in Denmark by using data from the national Danish Cholecystectomy Database (DCD). METHODS: In the DCD, two data sources were combined: administrative data from the National Patient Registry (NPR) and clinical data entered into the secure Web site by the surgeon immediately after the operation...
April 2014: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/24716563/biliary-dyskinesia-in-pediatrics
#20
REVIEW
Arvind Srinath, Miguel Saps, Klaus Bielefeldt
Biliary dyskinesia (BD) is a diagnosis that is being made increasingly in children. It is defined by abdominal pain thought to be biliary in nature based on location and character; a completely normal gallbladder on imaging tests, typically ultrasound; and decreased gallbladder contraction in response to a pharmacological stimulus. Unlike other functional gastrointestinal disorders (FGIDs) that are treated with medications, behavioral therapy, and/or dietary modification, current clinical practice has accepted cholecystectomy as the treatment of choice for BD, which now accounts for up to 50% of cholecystectomies in children...
April 2014: Pediatric Annals
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