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https://www.readbyqxmd.com/read/29668114/-%C3%AE-2-adrenoceptors-inhibit-neutrophil-extracellular-traps-in-human-polymorphonuclear-leukocytes
#1
Franca Marino, Angela Scanzano, Laura Pulze, Monica Pinoli, Emanuela Rasini, Alessandra Luini, Raffaella Bombelli, Massimiliano Legnaro, Magda de Eguileor, Marco Cosentino
This study tests the hypothesis that in isolated human polymorphonuclear leukocytes (PMN) adrenergic ligands can affect neutrophil extracellular trap (NET) formation. We have previously shown that, in PMN, adrenaline (A), through the activation of adrenergic receptors (AR), reduces stimulus-dependent cell activation; we have, therefore, planned to investigate if AR are involved in NET production. PMN were obtained from venous blood of healthy subject. The ability of adrenergic ligands to affect reactive oxygen species (ROS) production, NET production, and cell migration was investigated in cells cultured under resting conditions or after activation with N-formyl-methionyl-leucyl-phenylalanine (fMLP), LPS, or IL-8...
April 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29668113/molecular-dynamics-analysis-of-charge-transport-in-ionic-liquid-electrolytes-containing-added-salt-with-mono-di-and-trivalent-metal-cations
#2
José Manuel Vicent-Luna, Eneko Azaceta, Said Hamad, José Manuel Ortiz-Roldán, Ramón Tena-Zaera, Sofía Calero, Juan Antonio Anta
Among many other applications, room-temperature ionic liquids (ILs) are used as electrolytes for storage and energy-conversion devices. In this work, we investigate, at the microscopic level, the structural and dynamical properties of 1-methyl-1-butyl-pyrrolidinium bis(trifluoromethanesulfonyl) imide [C4 PYR]+ [Tf2 N]- IL-based electrolytes for metal-ion batteries. We carried out molecular dynamics simulations of electrolytes mainly composed of [C4 PYR]+ [Tf2 N]- IL with the addition of Mn+ -[Tf2 N]- metal salts (M=Li+ , Na+ , Ni2+ , Zn2+ , Co2+ , Cd2+ , and Al3+ , n=1, 2, and 3) dissolved in the IL...
April 18, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29668110/phenylbutyl-isoselenocyanate-induces-reactive-oxygen-species-to-inhibit-androgen-receptor-and-to-initiate-p53-mediated-apoptosis-in-lncap-prostate-cancer-cells
#3
Wei Wu, Deepkamal Karelia, Kartick Pramanik, Shantu G Amin, Arun K Sharma, Cheng Jiang, Junxuan Lu
Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. To explore its potential attributes against prostate cancer, we treated human LNCaP prostate cancer cells with ISC-4 and examined their apoptosis responses, and interrogated the signaling mechanisms through pharmacological and siRNA knockdown approaches. Our results show that ISC-4 was more potent at inducing apoptosis than its sulfur analog phenylbutyl isothiocyanate (PBITC) without suppressing protein kinase AKT Ser473 phosphorylation...
April 18, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29667909/losartan-does-not-decrease-renal-oxygenation-and-norepinephrine-effects-in-rats-after-resuscitated-haemorrhage
#4
Sofia Jönsson, Jacqueline M Melville, Mediha Becirovic-Agic, Michael Hultström
Renin-angiotensin-system blockers are thought to increase the risk of acute kidney injury after surgery and haemorrhage. We found that Losartan does not cause renal cortical hypoxia after haemorrhage in rats because of decreased renal vascular resistance, but did not evaluate resuscitation. AIM: Study Losartan´s effect on renal cortical and medullary oxygenation, and norepinephrine´s vasopressor effect in a model of resuscitated haemorrhage. METHOD: After seven days Losartan (60 mg/kg/day) or control treatment, male Wistar rats were haemorrhaged 20 % of the blood volume and resuscitated with Ringer's Acetate...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667856/low-oxygen-environment-facilitates-embryo-availability-for-older-ovarian-responders-pors
#5
Mingzhao Li, Zhibin Li, Juanzi Shi
We aimed to investigate the different effects of low oxygen (5% O2 ) and atmospheric oxygen (20% O2 ) on in vitro fertilization for older poor ovarian responders (PORs). We selected 1080 older PORs who met two criteria: (i) advanced maternal age (≥40) and (ii) an abnormal ovarian reserve test. All the patients used the ultra-short term protocols with GnRH agonist and recombinant FSH for controlled ovarian hyperstimulation (COH). About 506 cycles were performed in the incubators with 5% O2 and 574 cycles were performed in the incubators with 20% O2 ...
April 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29667838/general-synthetic-strategy-for-libraries-of-supported-multicomponent-metal-nanoparticles
#6
Hui Yang, Siobhan J Bradley, Xin Wu, Andrew Chan, Geoffrey I N Waterhouse, Thomas Nann, Jian Zhang, Paul E Kruger, Shengqian Ma, Shane G Telfer
Nanoparticles comprising three or more different metals are challenging to prepare. General methods that tackle this challenge are highly sought after as multicomponent metal nanoparticles display favorable properties in applications such as catalysis, biomedicine, and imaging. Herein, we report a practical and versatile approach for the synthesis of nanoparticles composed of up to four different metals. This method relies on the thermal decomposition of nanostructured composite materials assembled from platinum nanoparticles, a metal-organic framework (ZIF-8), and a tannic acid coordination polymer...
April 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29667835/oxygen-release-induced-chemomechanical-breakdown-of-layered-cathode-materials
#7
Linqin Mu, Ruoqian Lin, Rong Xu, Lili Han, Sihao Xia, Dimosthenis Sokaras, James Steiner, Tsu-Chien Weng, Dennis Nordlund, Marca M Doeff, Yijin Liu, Kejie Zhao, Huolin L Xin, Feng Lin
Chemical and mechanical properties interplay on the nanometric scale and collectively govern the functionalities of battery materials. Understanding the relationship between the two can inform the design of battery materials with optimal chemomechanical properties for long-life lithium batteries. Herein, we report a mechanism of nanoscale mechanical breakdown in layered oxide cathode materials, originating from oxygen release at high states of charge under thermal abuse conditions. We observe that the mechanical breakdown of charged Li1-xNi0...
April 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29667813/a-sensitive-water-soluble-reversible-optical-probe-for-hg-2-detection
#8
Sayani Das, Anindita Sarkar, Ananya Rakshit, Ankona Datta
We report the serendipitous discovery of an optical mercury sensor while trying to develop a water-soluble manganese probe. The sensor is based on a pentaaza macrocycle conjugated to a hemicyanine dye. The pentaaza macrocycle earlier designed in our group was used to develop photoinduced electron transfer (PET)-based "turn-on" fluorescent sensors for manganese. (1) In an attempt to increase the water-solubility of the manganese sensors we changed the dye from BODIPY to hemicyanine. The resultant molecule qHCM afforded a distinct reversible change in the absorption features and a concomitant visible color change upon binding to Hg2+ ions, leading to a highly water-soluble mercury sensor with a 10 ppb detection limit...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29667810/highly-stable-thin-film-transistors-based-on-indium-oxynitride-semiconductor
#9
Hyoung-Do Kim, Jong Heon Kim, Kyung Park, Yun Chang Park, Sunkook Kim, Yong Joo Kim, Jozeph Park, Hyun-Suk Kim
In this study, the properties of indium oxynitride (InON) semiconductor films grown by reactive radio frequency sputtering were examined both experimentally and theoretically. Also, thin film transistors (TFTs) incorporating InON as the active layer were evaluated for the first time. It is found that InON films exhibit high stability upon prolonged exposure to air, and the corresponding TFTs are more stable when subjected to negative bias illumination stress (NBIS), compared to devices based on indium oxide (In2O3) or zinc oxynitride (ZnON) semiconductors...
April 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#10
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29667659/correction-copper-mediated-regioselective-c-h-etherification-of-naphthylamides-with-arylboronic-acids-using-water-as-an-oxygen-source
#11
Subhasish Roy, Sourav Pradhan, Tharmalingam Punniyamurthy
Correction for 'Copper-mediated regioselective C-H etherification of naphthylamides with arylboronic acids using water as an oxygen source' by Subhasish Roy et al., Chem. Commun., 2018, DOI: 10.1039/c8cc02158a.
April 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29667555/synthesis-cytotoxicity-and-antioxidant-activity-of-new-analogues-of-rc-121-synthetic-derivatives-of-somatostatin
#12
Diana Wesselinova, Emilia D Naydenova, S Staykova, I G Goshev, L Vezenkov
BACKGROUND: Based on the structure of RC-121 (D-Phe-c (Cys-Tyr-D-Trp-Lys-Val-Cys)-Thr-NH2, - synthetic derivatives of somatostatin), some analogs were synthesized and tested for in vitro cytotoxic and antioxidant activity. OBJECTIVES: The new analogs were modifyed at position 5 with Dap (diaminopropanoic acid), Dab (diaminobutanoic acid) and Orn and at position 6 with the unnatural amino acids Tle (t-leucine). METHODS: The in vitro cytotoxic effects of the substances were investigated against a panel of human tumor cell lines HT-29 (human colorectal cancer cell line), MDA-MB-23 (human breast cancer cell line), Hep G-2 (human hepatocellular carcinoma cell line) and HeLa (cervical cancer cell line)...
April 17, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29667461/oxygen-inhalation-of-heart-disease-patients-at-home
#13
Shanshan An, Wenwen Yu, Fan Feng, Qiuyun Liu
No abstract text is available yet for this article.
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29667418/granulatosides-d-e-and-other-polar-steroid-compounds-from-the-starfish-choriaster-granulatus-their-immunomodulatory-activity-and-cytotoxicity
#14
Natalia V Ivanchina, Alla A Kicha, Timofey V Malyarenko, Sofiya D Ermolaeva, Ekaterina A Yurchenko, Evgeny A Pislyagin, Chau Van Minh, Pavel S Dmitrenok
Two new steroid glycosides, granulatosides D (1) and E (2), belonging to the group of bi- and monoglycosides of polyhydroxysteroids, respectively, were isolated from the ethanolic extract of the starfish Choriaster granulatus along with thirteen previously known glycosides of polyhydroxysteroids (3-15) and one steroid heptaol (16). The structures of the new compounds were elucidated by extensive NMR and ESIMS techniques. Cytotoxic and immunomodulatory activities of compounds 1, 3-8, and 10-16 using murine splenocytes and peritoneal macrophages were studied...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29667363/a-rechargeable-high-temperature-molten-salt-iron-oxygen-battery
#15
Cheng Peng, Chengzhi Guan, Jun Lin, Shiyu Zhang, Hongliang Bao, Yu Wang, Guoping Xiao, George Zheng Chen, Jianqiang Wang
The energy and power density of conventional batteries are far lower than their theoretical expectations, primarily because of the slow reaction kinetics in the battery that is often working under ambient conditions. Here we describe a low-cost and high-temperature rechargeable iron-oxygen battery containing a cascade bi-phase electrolyte of molten carbonate and solid oxide. This new design merges the merits of solid oxide fuel cell and molten metal-air battery, offering significantly improved battery reaction kinetics and hence the power capability without compromising the energy capacity...
April 17, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29667348/defective-n-s-codoped-3d-cheese-like-porous-carbon-nanomaterial-toward-efficient-oxygen-reduction-and-zn-air-batteries
#16
Jiawei Zhu, Wenqiang Li, Shuaihu Li, Jian Zhang, Huang Zhou, Chengtian Zhang, Jianan Zhang, Shichun Mu
Developing a facile and cost-efficient method to synthesize carbon-based nanomaterials possessing excellent structural and functional properties has become one of the most attractive topics in energy conversion and storage fields. In this study, density functional theory calculation results reveal the origin of high oxygen reduction reaction (ORR) activity predominantly derived from the synergistic effect of intrinsic defects and heteroatom dopants (e.g., N, S) that modulate the bandgap and charge density distribution of carbon matrix...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667293/enhanced-in-vitro-biocompatibility-and-water-dispersibility-of-magnetite-and-cobalt-ferrite-nanoparticles-employed-as-ros-formation-enhancer-in-radiation-cancer-therapy
#17
Stefanie Klein, Melek Kızaloğlu, Luis Portilla, Hyoungwon Park, Tobias Rejek, Julian Hümmer, Karsten Meyer, Rainer Hock, Luitpold V R Distel, Marcus Halik, Carola Kryschi
Efficient magnetic reactive oxygen species (ROS) formation enhancing agents after X-ray treatment are realized by functionalizing superparamagnetic magnetite (Fe3 O4 ) and Co-ferrite (CoFe2 O4 ) nanoparticles with self-assembled monolayers (SAMs). The Fe3 O4 and CoFe2 O4 nanoparticles are synthesized using Massart's coprecipitation technique. Successful surface modification with the SAM forming compounds 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide, or (2-{2-[2-hydroxy-ethoxy]-ethoxy}-ethyl phosphonic acid provides biocompatibility and long-term stability of the Fe3 O4 and CoFe2 O4 nanoparticles in cell media...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667201/functioning-of-potassium-and-magnesium-in-photosynthesis-photosynthate-translocation-and-photoprotection
#18
Merle Tränkner, Ershad Tavakol, Bálint Jákli
Potassium (K) and magnesium (Mg) are mineral nutrients that are required in large quantities by plants. Both elements critically contribute to the process of photosynthesis and the subsequent long-distance transport of photoassimilates. If K or Mg are not present in sufficient quantities in photosynthetic tissues, complex interactions of anatomical, physiological and biochemical responses result in a reduction of photosynthetic carbon assimilation. As a consequence, excessive production of reactive oxygen species causes photooxidation of the photosynthetic apparatus and cause an up-regulation of photoprotective mechanisms...
April 18, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29667172/mapping-the-origins-of-imperial-roman-workers-1st-4th-century-ce-at-vagnari-southern-italy-using-87-sr-86-sr-and-%C3%AE-18-o-variability
#19
Matthew V Emery, Robert J Stark, Tyler J Murchie, Spencer Elford, Henry P Schwarcz, Tracy L Prowse
OBJECTIVES: We obtained the oxygen and strontium isotope composition of teeth from Roman period (1st to 4th century CE) inhabitants buried in the Vagnari cemetery (Southern Italy), and present the first strontium isotope variation map of the Italian peninsula using previously published data sets and new strontium data. We test the hypothesis that the Vagnari population was predominantly composed of local individuals, instead of migrants originating from abroad. MATERIALS AND METHODS: We analyzed the oxygen (18 O/16 O) and strontium (87 Sr/86 Sr) isotope composition of 43 teeth...
April 18, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29667162/metaunidec-high-throughput-deconvolution-of-native-mass-spectra
#20
Deseree J Reid, Jessica M Diesing, Matthew A Miller, Scott M Perry, Jessica A Wales, William R Montfort, Michael T Marty
The expansion of native mass spectrometry (MS) methods for both academic and industrial applications has created a substantial need for analysis of large native MS datasets. Existing software tools are poorly suited for high-throughput deconvolution of native electrospray mass spectra from intact proteins and protein complexes. The UniDec Bayesian deconvolution algorithm is uniquely well suited for high-throughput analysis due to its speed and robustness but was previously tailored towards individual spectra...
April 17, 2018: Journal of the American Society for Mass Spectrometry
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