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https://www.readbyqxmd.com/read/27926976/are-cytokines-useful-biomarkers-to-determine-disease-severity-in-neonates-with-congenital-diaphragmatic-hernia
#1
Thomas Schaible, Janine Reineke, Ludwig Gortner, Dominik Monz, Regine Schaffelder, Erol Tutdibi
Background This study investigates plasma cytokine levels in neonates with the more common left-sided congenital diaphragmatic hernia (CDH) and correlates them with severity of disease indicated by position of the liver. An intrathoracic part of liver is associated with higher need for extracorporeal membrane oxygenation (ECMO) and higher risk for chronic lung disease (CLD). Methods A total of 28 newborns with CDH were subdivided by their liver position in partially intrathoracic (n = 16) and only abdominal (n = 12) position...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926959/-the-history-of-oxygen-from-its-discovery-to-its-implementation-as-medical-therapy
#2
N Koehler, M Goubeaud, O Hildebrandt, A K Sohrabi, U Koehler
No abstract text is available yet for this article.
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27926944/targeting-neutrophils-to-prevent-malaria-associated-acute-lung-injury-acute-respiratory-distress-syndrome-in-mice
#3
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R D' Império Lima, José M Alvarez, Silvia Portugal, Claudio R F Marinho, Sabrina Epiphanio
Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926857/a-lon-clpp-proteolytic-axis-degrades-complex-i-to-extinguish-ros-production-in-depolarized-mitochondria
#4
Kenneth Robert Pryde, Jan Willem Taanman, Anthony Henry Schapira
Mitochondrial dysfunction is implicated in numerous neurodegenerative disorders and in Parkinson's disease (PD) in particular. PINK1 and Parkin gene mutations are causes of autosomal recessive PD, and these respective proteins function cooperatively to degrade depolarized mitochondria (mitophagy). It is widely assumed that impaired mitophagy causes PD, as toxic reactive oxygen species (ROS)-producing mitochondria accumulate and progressively drive neurodegeneration. Instead, we report that a LON-ClpP proteolytic quality control axis extinguishes ROS in depolarized mitochondria by degrading the complex I ROS-generating domain...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926636/feasibility-and-outcomes-of-fetoscopic-tracheal-occlusion-for-severe-left-diaphragmatic-hernia
#5
Michael A Belfort, Oluyinka O Olutoye, Darrell L Cass, Olutoyin A Olutoye, Christopher I Cassady, Amy R Mehollin-Ray, Alireza A Shamshiraz, Stephanie M Cruz, Timothy C Lee, David G Mann, Jimmy E Espinoza, Stephen E Welty, Caraciolo J Fernandes, Rodrigo R Ruano
OBJECTIVE: To evaluate feasibility and initial outcomes of fetoscopic tracheal occlusion for severe diaphragmatic hernia compared with a historical cohort who had not received fetal tracheal occlusion. METHODS: Outcomes in a prospective observational cohort who underwent fetoscopic tracheal occlusion for severe fetal left diaphragmatic hernia without associated anomalies were compared with our historical nontreated cohort of matched fetuses of similar severity. Fetuses were classified using the same ultrasonography and magnetic resonance imaging methodology-prospectively in the fetoscopic tracheal occlusion group and retrospectively in the historical nontreated cohort...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926513/mael-is-essential-for-cancer-cell-survival-and-tumorigenesis-through-protection-of-genetic-integrity
#6
Su-Hyeon Kim, Eun-Ran Park, Eugene Cho, Won-Hee Jung, Ju-Yeon Jeon, Hyun-Yoo Joo, Kee-Ho Lee, Hyun-Jin Shin
Germ line-specific genes are activated in somatic cells during tumorigenesis, and are accordingly referred to as cancer germline genes. Such genes that act on piRNA (Piwi-interacting RNA) processing play an important role in the progression of cancer cells. Here, we show that the spermatogenic transposon silencer maelstrom (Mael), a piRNA-processing factor, is required for malignant transformation and survival of cancer cells. A specific Mael isoform was distinctively overexpressed in diverse human cancer cell lines and its depletion resulted in cancer-specific cell death, characterized by apoptosis and senescence, accompanied by an increase in reactive oxygen-species and DNA damage...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925778/treating-hypoxemia-with-supplemental-oxygen-same-game-different-rules
#7
Darryl Y Sue
No abstract text is available yet for this article.
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27925730/intrinsic-ferromagnetism-in-the-diluted-magnetic-semiconductor-co-tio_-2
#8
H Saadaoui, X Luo, Z Salman, X Y Cui, N N Bao, P Bao, R K Zheng, L T Tseng, Y H Du, T Prokscha, A Suter, T Liu, Y R Wang, S Li, J Ding, S P Ringer, E Morenzoni, J B Yi
Here we present a study of magnetism in Co_{0.05}Ti_{0.95}O_{2-δ} anatase films grown by pulsed laser deposition under a variety of oxygen partial pressures and deposition rates. Energy-dispersive spectrometry and transmission electron microscopy analyses indicate that a high deposition rate leads to a homogeneous microstructure, while a very low rate or postannealing results in cobalt clustering. Depth resolved low-energy muon spin rotation experiments show that films grown at a low oxygen partial pressure (≈10^{-6}  torr) with a uniform structure are fully magnetic, indicating intrinsic ferromagnetism...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925576/comparison-of-oxygen-transfer-parameters-and-oxygen-demands-in-bioreactors-operated-at-low-and-high-dissolved-oxygen-levels
#9
Richard O Mines, Matthew C Callier, Benjamin J Drabek, André J Butler
The proper design of aeration systems for bioreactors is critical since it can represent up to 50% of the operational and capital cost at water reclamation facilities. Transferring the actual amount of oxygen needed to meet the oxygen demand of the wastewater requires α- and β-factors, which are used for calculating the actual oxygen transfer rate (AOTR) under process conditions based on the standard oxygen transfer rate (SOTR). The SOTR is measured in tap water at 20°C, 1 atmospheric pressure, and 0 mg L(-1) of dissolved oxygen (DO)...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27925481/mitochondrial-ros-uncoupled-from-atp-synthesis-determine-endothelial-activation-for-both-physiological-recruitment-of-patrolling-cells-and-pathological-recruitment-of-inflammatory-cells
#10
Xinyuan Li, Pu Fang, William Y Yang, Kylie Chan, Muriel Lavallee, Keman Xu, Tracy Gao, Hong Wang, Xiaofeng Yang
Mitochondrial reactive oxygen species (mtROS) are signaling molecules, which drive inflammatory cytokine production and T cell activation. In addition, cardiovascular diseases, cancers, and autoimmune diseases all share a common feature of increased mtROS level. Both mtROS and ATP are produced as a result of electron transport chain activity, but it remains enigmatic whether mtROS could be generated independently from ATP synthesis. A recent study shed light on this important question and found that, during endothelial cell (EC) activation, mtROS could be upregulated in a proton leak-coupled, but ATP synthesis-uncoupled manner...
November 5, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27925468/the-prediction-of-radiofrequency-ablation-zone-volume-using-vascular-indices-of-3-dimensional-volumetric-color-doppler-ultrasound-in-an-in-vitro-blood-perfused-bovine-liver-model
#11
Samuel Chang, Anthony C Lanctot, Martin D McCarter, Katherine M Roberts, Deborah H Glueck, Gerald D Dodd
OBJECTIVE: To determine the most reliable predictor of radiofrequency (RF) ablation zone volume among 3D volumetric color Doppler vascular indices in in-vitro blood-perfused bovine liver model. METHODS: 3D color Doppler volume data of the local hepatic parenchyma were acquired from 37 areas of 13 bovine livers connected to in-vitro oxygenated blood perfusion system. Doppler vascular indices of vascularization index (VI), flow index (FI), and vascularization-flow index (VFI) were obtained from the volume data using a 3D volume analysis software...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27925460/nir-mediated-nanohybrids-of-upconversion-nanophosphors-and-fluorescent-conjugated-polymers-for-high-efficiency-antibacterial-performance-based-on-fluorescence-resonance-energy-transfer
#12
Junting Li, Qi Zhao, Feng Shi, Chenghui Liu, Yanli Tang
A novel nanohybrid comprised of upconversion nanophosphors (UCNPs) and fluorescent conjugated polymers (PFVCN) is rationally fabricated. The new UCNP/PFVCN nanohybrids combine the excellent antibacterial ability of PFVCN and the near IR (NIR) absorbing property of UCNPs, which allows for NIR-mediated antibacterial through the effective fluorescence resonance energy transfer from UCNPs to PFVCN accompanied with generation of reactive oxygen species to kill bacteria.
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27925430/pulmonary-hypertension-as-estimated-by-doppler-echocardiography-in-adolescent-and-adult-patients-with-cystic-fibrosis-and-their-relationship-with-clinical-lung-function-and-sleep-findings
#13
Bruna Ziegler, Christiano Perin, Fernanda Cano Casarotto, Simone Chaves Fagondes, Sérgio Saldanha Menna-Barreto, Paulo de Tarso Roth Dalcin
BACKGROUND: In cystic fibrosis (CF) patients, end stage of pulmonary disease is characterized by pulmonary hypertension (PH), hypoxemia, decrease in exercise tolerance and sleep quality. OBJECTIVE: To evaluate the association between clinical, lung function, sleep quality and polysomnographic variables with PH in CF patients aged 16 years or older. METHODS: In a cross-sectional study, 51 clinically stable CF patients underwent a clinical evaluation, an overnight polysomnography and answered sleep questionnaires (Pittsburgh Sleep Quality Index - PSQI and Epworth sleepiness scale - ESS)...
December 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27925413/mechanism-of-water-oxidation-catalysed-by-a-mononuclear-manganese-complex-py2n-tbu-2mn-h2o-2-2
#14
Yingying Li, Ke Ye, Per E M Siegbahn, Rong-Zhen Liao
The design and synthesis of biomimetic Mn complexes to catalyze oxygen evolution is a very appealing goal since water oxidation in nature employs manganese. A mononuclear Mn complex 1 [LMnII(H2O)2]2+ (L=Py2N(tBu)2) was recently reported to catalyze water oxidation electrochemically with an applied potential of 1.23 V at pH=12.2 in aqueous solution. Density functional calculations have here been performed to elucidate the mechanism of water oxidation promoted by this catalyst. The calculations showed that 1 can readily lose two protons and one electron with the production of 2 [LMnIII(OH)2]+, which then undergoes two sequential proton-coupled electron transfer processes to afford 4 [LMnVOO]+...
December 7, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27925403/heterogeneously-catalyzed-aerobic-oxidation-of-5-hydroxymethylfurfural-to-2-5-furandicarboxylic-acid-with-manganese-dioxide
#15
Eri Hayashi, Tasuku Komanoya, Keigo Kamata, Michikazu Hara
A simple non-precious metal catalyst system based on cost-effective and ubiquitously available MnO2, NaHCO3, and molecular oxygen was used to convert 5-hydroxymethylfurfural to 2,5-difurandicarboxylic acid as a bioplastics precursor in 91% yield. The MnO2 catalyst could be recovered by simple filtration and reused several times. The present system was also applicable to the aerobic oxidation of other biomass-derived substrates and the gram-scale oxidation of HMF to FDCA, in which 2.36 g (86% yield) of the analytically pure FDCA could be isolated...
December 7, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27925402/two-new-oxygen-containing-biomarkers-isolated-from-the-chinese-maoming-oil-shale-by-silica-gel-column-chromatography-and-preparative-gas-chromatography
#16
Xiangyun Zhang, Hong Lu, Jing Liao, Caiming Tang, Guoying Sheng, Ping'an Peng
Two biomarkers, 5,9-dimethyl-6-isopropyl-2-decanone (1) and 4,9,11-trimethyl-6-isopropyl-2-dodecanone (2), were isolated from Chinese Maoming Oil Shale by silica gel column chromatography and preparative gas chromatography. Their structures were elucidated by using spectroscopic techniques. This article is protected by copyright. All rights reserved.
December 7, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27925400/hydrothermal-carbon-enriched-with-oxygenated-groups-from-biomass-glucose-as-an-efficient-carbocatalyst
#17
Guodong Wen, Bolun Wang, Congxin Wang, Jia Wang, Zhijian Tian, Robert Schlögl, Dang Sheng Su
Metal-free carbocatalysts enriched with specific oxygenated groups with different morphology and size were synthesized from glucose by hydrothermal carbonization, in which cheap and widely available biomass could be converted into functionalized carbon using an environmentally benign process. The hydroxy- and carbonyl-enriched hydrothermal carbon (HTC) could be used in nitrobenzene reduction, and higher conversion was obtained on the sphere morphology with smaller size. In the Beckmann rearrangement of cyclohexanone oxime, carboxyl-enriched HTC exhibited superior performance compared with conventional solid acid (such as HY and HZSM-5), on which the strong acid sites and weak Lewis acid sites lead to high selectivity for the side product...
December 7, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27925393/intensive-care-unit-icu-readmission-after-major-lung-resection-prevalence-patterns-and-mortality
#18
Jae Jun Jung, Jong Ho Cho, Tae Hee Hong, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Jae Ill Zo
BACKGROUND: The aim of this study was to identify risk factors associated with mortality in patients re-admitted to an intensive care unit (ICU) after initial recovery from major lung resection. METHODS: We retrospectively reviewed the case records of all patients who underwent major lung resection between February 2011 and May 2013. A total of 1916 patients underwent major resection surgery for various lung diseases, 63 (3.3%) of which required ICU admission after initial recovery...
December 7, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27925379/cu-oh-2-coco3-oh-2-%C3%A2-nh2-o-core-shell-heterostructure-nanowire-array-an-efficient-3d-anodic-catalyst-for-oxygen-evolution-and-methanol-electrooxidation
#19
Lisi Xie, Chun Tang, Kunyang Wang, Gu Du, Abdullah M Asiri, Xuping Sun
A Cu(OH)2 @CoCO3 (OH)2 ·nH2 O (CCHH) core-shell heterostructure nanowire array acts as robust 3D oxygen evolution reaction catalyst. It needs overpotential of 270 mV to drive 50 mA cm(-2) in 1.0 m KOH, outperforming CCHH nanowire array on copper foam and most reported Co-based oxygen evolution reaction catalysts in alkaline media. It is also efficient for methanol electrooxidation.
December 7, 2016: Small
https://www.readbyqxmd.com/read/27925316/functional-species-encapsulated-in-nitrogen-doped-porous-carbon-as-a-highly-efficient-catalyst-to-oxygen-reduction-reaction
#20
Li Song, Tao Wang, Yiou Ma, Hairong Xue, Hu Guo, Xiaoli Fan, Wei Xia, Hao Gong, Jianping He
The scarcity, high cost and poor stability of precious metal-based electrocatalysts have stimulated the development of novel non-precious metal catalysts to oxygen reduction reaction (ORR) for the use in fuel cells and metal-air batteries. Here, we in-situ fabricated a hybrid material (Co-W-C/N) with functional species (tungsten carbide and cobalt nanoparticles) encapsulated in N-doped porous carbon framework, through a facile multi-constituents co-assembly method combined with subsequent annealing treatment...
December 7, 2016: Chemistry: a European Journal
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