keyword
MENU ▼
Read by QxMD icon Read
search

Oxygenator

keyword
https://www.readbyqxmd.com/read/29458170/downregulation-of-metabotropic-glutamate-receptor-5-inhibits-hepatoma-development-in-a-neurotoxin-rotenone-induced-parkinson-s-disease-model
#1
Xiao Xu Bai, Li Gu, Hui Min Yang, Shao Song Xi, Ning Xia, Song Zhang, Hong Zhang
Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5 ) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo. We found that conditioned media derived from MN9D dopaminergic neuronal cells by rotenone-induced toxicity inhibited the growth, migration, invasion and promoted apoptosis of Hepa1-6 cells, which corresponded with decreased expression of mGlu5 ...
February 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29458159/strawberry-extracts-efficiently-counteract-inflammatory-stress-induced-by-the-endotoxin-lipopolysaccharide-in-human-dermal-fibroblast
#2
Massimiliano Gasparrini, Francesca Giampieri, Tamara Y Forbes-Hernandez, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, JiaoJiao Zhang, Josè L Quiles, Bruno Mezzetti, Stefano Bompadre, Maurizio Battino
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458150/pink1-protects-auditory-hair-cells-and-spiral-ganglion-neurons-from-cisplatin-induced-ototoxicity-via-inducing-autophagy-and-inhibiting-jnk-signaling-pathway
#3
Qianqian Yang, Gaoying Sun, Haiyan Yin, Hongrui Li, Zhixin Cao, Jinghan Wang, Meijuan Zhou, Haibo Wang, Jianfeng Li
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) gene encodes a serine/threonine kinase, which acts as a molecular sensor of mitochondrial health necessary for mitochondrial quality control. The present study was designed to examine whether PINK1 expressed in C57BL/6 murine cochlea and HEI-OC1 cells and, if so, to investigate the possible mechanisms underlying the action of PINK1 in cisplatin-induced death of sensory hair cells (HCs) and spiral ganglion neurons (SGNs) in vitro. The expression pattern of PINK1, formation of parkin particles, and autophagy were determined by immunofluorescent staining...
February 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29458114/severity-dependent-influence-of-isocapnic-hypoxia-on-reaction-time-is-independent-of-neurovascular-coupling
#4
Hannah G Caldwell, Geoff B Coombs, Michael M Tymko, Daniela Nowak-Flück, Philip N Ainslie
With exposure to acute normobaric hypoxia, global cerebral oxygen delivery is maintained via increases in cerebral blood flow (CBF); therefore, regional and localized changes in oxygen tension may explain neurocognitive impairment. Neurovascular coupling (NVC) is the close temporal and regional relationship of CBF to changes in neural activity and may aid in explaining the localized CBF response with cognitive activation. High-altitude related cognitive impairment is likely affected by hypocapnic cerebral vasoconstriction that may influence regional CBF regulation independent of hypoxia...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458113/poorer-positive-affect-in-response-to-self-paced-exercise-among-the-obese
#5
Hassan M Elsangedy, Paulo H D Nascimento, Daniel G S Machado, Kleverton Krinski, Sarah J Hardcastle, Sérgio G DaSilva
We aimed to investigate the association between body mass index (BMI) and affective response, ratings of perceived exertion (RPE), and physiological responses during self-paced exercise. Sixty-six women were divided into three groups accordingly with the BMI: obese (n = 22: 33.5 ± 8.5 yr; 34.9 ± 4.1 kg∙m-2 ), overweight (n = 22: 34.8 ± 8.6 yr; 26.4 ± 1.3 kg∙m-2 ), and normal-weight (n = 22: 30.8 ± 9.3 yr; 22.0 ± 1.6 kg∙m-2 ). They underwent a graded exercise test and a 20-min self-paced walking session on a treadmill...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458045/aldose-reductase-inhibitor-fidarestat-prevents-doxorubicin-induced-endothelial-cell-death-and-dysfunction
#6
Himangshu Sonowal, Pabitra Pal, Kirtikar Shukla, Ashish Saxena, Satish K Srivastava, Kota V Ramana
Despite doxorubicin (Dox) being one of the most widely used chemotherapy agents for breast, blood and lung cancers, its use in colon cancer is limited due to increased drug resistance and severe cardiotoxic side effects that increase mortality associated with its use at high doses. Therefore, better adjuvant therapies are warranted to improve the chemotherapeutic efficacy and to decrease cardiotoxicity. We have recently shown that aldose reductase inhibitor, fidarestat, increases the Dox-induced colon cancer cell death and reduces cardiomyopathy...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29458041/role-of-superoxide-ion-formation-in-hypothermia-rewarming-induced-contractile-dysfunction-in-cardiomyocytes
#7
Niccole Schaible, Young Soo Han, Torkjel Tveita, Gary C Sieck
Rewarming following accidental hypothermia is associated with circulatory collapse due primarily to impaired cardiac contractile (systolic) function. Previously, we found that reduced myofilament Ca2+ sensitivity underlies hypothermia/rewarming (H/R)-induced cardiac contractile dysfunction. This reduced Ca2+ sensitivity is associated with troponin I (cTnI) phosphorylation. We hypothesize that H/R induces reactive oxygen species (ROS) formation in cardiomyocytes, which leads to cTnI phosphorylation and reduced myofilament Ca2+ sensitivity...
February 16, 2018: Cryobiology
https://www.readbyqxmd.com/read/29458008/trefoil-factor-2-promotes-type-2-immunity-and-lung-repair-through-intrinsic-roles-in-hematopoietic-and-non-hematopoietic-cells
#8
Li-Yin Hung, Taylor K Oniskey, Debasish Sen, Matthew F Krummel, Andrew E Vaughan, Noam A Cohen, De'Broski R Herbert
Trefoil factors are small secreted proteins that regulate tissue integrity and repair at mucosal surfaces, particularly in the gastrointestinal tract. However, their relative contribution(s) to controlling baseline lung function or the extent of infection-induced lung injury are unknown issues. Using irradiation bone marrow chimeras, we found that Trefoil factor 2 (TFF2) produced from both hematopoietic- and non-hematopoietic-derived cells is essential for host protection, proliferation of alveolar type 2 cells, and restoration of pulmonary gas exchange following infection with the hookworm parasite Nippostrongylus brasiliensis...
February 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29458000/evidence-for-a-mitochondrial-atp-regulated-potassium-channel-in-human-dermal-fibroblasts
#9
Piotr Bednarczyk, Anna Kicinska, Michal Laskowski, Bogusz Kulawiak, Rafal Kampa, Agnieszka Walewska, Milena Krajewska, Wieslawa Jarmuszkiewicz, Adam Szewczyk
Mitochondrial ATP-regulated potassium channels are present in the inner membrane of the mitochondria of various cells. In the present study, we show for the first time mitochondrial ATP-regulated potassium channels in human dermal fibroblast cells. Using the patch-clamp technique on the inner mitochondrial membrane of fibroblasts, we detected a potassium channel with a mean conductance equal to 100 pS in symmetric 150 mM KCl. The activity of this channel was inhibited by a complex of ATP/Mg2+ and activated by potassium channel openers such as diazoxide or BMS 191095...
February 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29457973/pyrazole-tetrazole-hybrid-bearing-the-trinitromethyl-fluorodinitromethyl-or-difluoroamino-dinitromethyl-groups-high-performance-energetic-materials
#10
Aleksei B Sheremetev, Igor L Dalinger, Nikita V Muravyev, Kyrill Yu Suponitsky, Aleksandr V Kormanov
High nitrogen compounds have acquired great scientific interest and technological importance because of their unique energy content, and they find diverse applications in many fields of science and technology. Understanding of structure-property relationship trends as well as how to modify them is of paramount importance for their further improvement. Herein, we have used installation of oxygen-rich modules, C(NO2)3, C(NO2)2F or C(NO2)2NF2, to a endothermic framework, that is combination of nitropyrazole unit and tetrazole ring, as a way to design novel energetic compounds...
February 19, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29457971/visible-light-photocatalysis-does-it-make-a-difference-in-organic-synthesis
#11
Leyre Marzo, Santhosh K Pagire, Oliver Reiser, Burkhard König
Visible light photocatalysis has evolved over the last decade into a widely used method in organic synthesis. For many important transformations, such as cross-coupling reactions, alpha-amino functionalizations, cycloadditions, ATRA reactions, or fluorinations, photocatalytic variants have been reported. In this review, we try to compare classical and photocatalytic procedures for selected classes of reactions and highlight their advantages and limitations. In many cases, the photocatalytic reactions proceed at milder reaction conditions, typically at room temperature, and stoichiometric reagents are replaced by simple oxidants or reductants, like air oxygen or amines...
February 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29457905/computational-investigation-on-the-influence-of-halogen-atoms-on-the-photophysical-properties-of-tetraphenylporphyrin-and-its-zinc-ii-complexes
#12
Bruna Clara De Simone, Gloria Mazzone, Nino Russo, Emilia Sicilia, Marirosa Toscano
How the tetraphenylporphyrin (TPP) and its zinc (II) complex (ZnTPP) photophysical properties (adsorption energies, singlet-triplet energy gap and spin orbit coupling contributions) can change due to the presence of an increasing number of heavy atoms in their molecular structures has been investigated by means of density functional theory and its time dependent formulation. Results show as the increase of the atomic mass of the substituted halogen strongly enhances the spin-orbit coupling values allowing a more efficient singlet-triplet intersystem crossing...
February 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29457897/macrocyclic-oligofurans-a-computational-study
#13
Or Dishi, Ori Gidron
Macrocyclic oligothiophenes (nCT) have been extensively explored for their unique optical and electronic properties, while their oxygen containing analogs, macrocyclic oligofurans (nCF), are not known. In this work, macrocyclic oligofurans bearing 5 to 16 units (5CF-16CF) are studied theoretically at the B3LYP/6-311G(d) level. We find that small macrocycles (6CF-8CF) exhibit planar or nearly-planar geometries, low strain energies, low HOMO-LUMO gaps, and strong π-conjugation as also reflected in their Raman spectra...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29457884/unique-biochemical-and-sequence-features-enable-blub-to-destroy-flavin-and-distinguish-blub-from-the-flavin-monooxygenase-superfamily
#14
Amrita B Hazra, David P Ballou, Michiko E Taga
Vitamin B12 (cobalamin) is an essential micronutrient for humans that is synthesized only by a subset of bacteria and archaea. The aerobic biosynthesis of 5,6-dimethylbenzimidazole, the lower axial ligand of cobalamin is catalyzed by the "flavin destructase" enzyme BluB, which fragments reduced flavin mononucleotide following its reaction with oxygen to yield this ligand. BluB shares sequence and structural similarity with the flavin oxidoreductase superfamily, yet the flavin destruction process has remained elusive...
February 19, 2018: Biochemistry
https://www.readbyqxmd.com/read/29457883/mapping-the-h-nox-hk-binding-interface-in-vibrio-cholerae-by-hydrogen-deuterium-exchange-mass-spectrometry
#15
Yirui Guo, Anthony T Iavarone, Matthew M Cooper, Michael A Marletta
Heme-nitric oxide/oxygen binding (H-NOX) proteins are a group of hemoproteins that bind diatomic gas ligands such as nitric oxide (NO) and oxygen (O2 ). H-NOX proteins typically regulate histidine kinases (HK) located within the same operon. It has been reported that NO-bound H-NOXs inhibit cognate histidine kinase autophosphorylation in bacterial H-NOX/HK complexes, however, a detailed mechanism of NO-mediated regulation of the H-NOX/HK activity remains unknown. In this study, the binding interface of Vibrio cholerae (Vc) H-NOX/HK complex was characterized by hydrogen/deuterium exchange mass spectrometry (HDX-MS) and further validated by mutagenesis, leading to a new model for NO-dependent kinase inhibition...
February 19, 2018: Biochemistry
https://www.readbyqxmd.com/read/29457861/promoted-fixation-of-molecular-nitrogen-with-surface-oxygen-vacancies-on-plasmon-enhanced-tio2-photoelectrodes
#16
Chengcheng Li, Tuo Wang, Zhi-Jian Zhao, Weimin Yang, Jianfeng Li, Ang Li, Zhilin Yang, Geoffrey A Ozin, Jinlong Gong
A hundred years on energy-intensive Haber-Bosch process continuously turn the nitrogen in air into fertilizer, nourishing billions of people while causing pollution and greenhouse gas emissions. The urgency of mitigating climate change motivates people to progress towards a more sustainable way in fixing nitrogen based on clean energy. Surface oxygen vacancies (surface Ovac) hold great potential for N2 adsorption and activation, but introducing Ovac on the very surface without affecting bulk properties remains a great challenge...
February 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29457851/suppression-of-microrna-144-3p-attenuates-oxygen-glucose-deprivation-reoxygenation-induced-neuronal-injury-by-promoting-brg1-nrf2-are-signaling
#17
Yanru Li, Yongli Zhao, Mingkun Cheng, Yingjie Qiao, Yongtao Wang, Wancheng Xiong, Wei Yue
Accumulating evidence has reported that microRNA-144-3p (miR-144-3p) is highly related to oxidative stress and apoptosis. However, little is known regarding its role in cerebral ischemia/reperfusion-induced neuronal injury. Herein, our results showed that miR-144-3p expression was significantly downregulated in neurons following oxygen-glucose deprivation and reoxygenation (OGD/R) treatment. Overexpression of miR-144-3p markedly reduced cell viability, promoted cell apoptosis, and increased oxidative stress in neurons with OGD/R treatment, whereas downregulation of miR-144-3p protected neurons against OGD/R-induced injury...
February 19, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29457833/a-green-method-to-determine-vuv-185-nm-fluence-rate-based-on-hydrogen-peroxide-production-in-aqueous-solution
#18
Laxiang Yang, Mengkai Li, Wentao Li, James R Bolton, Zhimin Qiang
A mini-fluidic vacuum ultraviolet/ultraviolet (VUV/UV) photoreaction system (MVPS) was developed in our previous study. Based on the MVPS, a green method to determine VUV fluence rate has been developed using the production rate of H2 O2 when water is exposed to 185 nm VUV. The H2 O2 production followed pseudo-zero-order reaction kinetics well over the first 10 min of VUV/UV exposure. This new method was well calibrated with a standard cis-cyclooctene cis-trans photoisomerization actinometer as recommended by the International Union of Pure and Applied Chemistry...
February 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29457816/iodine-promoted-dual-oxidative-c-sp-3-h-amination-of-2-methyl-3-arylquinazolin-4-3h-ones-a-facile-route-to-1-4-diarylimidazo-1-5-a-quinazolin-5-4h-ones
#19
Kavitha Donthiboina, Hari Krishna Namballa, Siddiq Pasha Shaik, Jagadeesh Babu Nanubolu, Nagula Shankaraiah, Ahmed Kamal
An iodine promoted tandem oxidative condensation of benzylamines and 2-methylquinazolin-4-(3H)-ones was developed to yield imidazo[1,5-a]quinazolin-5(4H)-ones via dual C(sp3 )-H amination under metal free conditions in a greener way using molecular oxygen as a terminal oxidant. This tandem transformation provides an efficient approach to construct various functionalized imidazo[1,5-a]quinazolin-5(4H)-ones in a straightforward manner via a sequential amination-oxidation-annulation-aromatisation.
February 19, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29457806/enhancement-of-the-selectivity-of-mxenes-m-2-c-m-ti-v-nb-mo-via-oxygen-functionalization-promising-materials-for-gas-sensing-and-separation
#20
A Junkaew, R Arróyave
Two-dimensional graphene-like materials, namely MXenes, have been proposed as potential materials for various applications. In this work, the reactivity and selectivity of four MXenes (i.e. M2 C (M = Ti, V, Nb, Mo)) and their oxygen-functionalized forms (i.e. O-MXenes or M2 CO2 ) toward gas molecules were investigated by using the plane wave-based Density Functional Theory (DFT) calculations. Small gas molecules, which are commonly found in flue gas streams, are considered herein. Our results demonstrated that MXenes are very reactive...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
keyword
keyword
48216
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"