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https://www.readbyqxmd.com/read/29643543/-airway-foreign-body-caused-by-aspiration-of-artificial-nasal-sponge-a-case-report
#1
T X Fu, X Wang, M L Liu
57-year-old male was admitted to hospital for severe headache and seizure attacks on November 6th, 2016. After radiology and spinal fluid examination, he was diagnosed with viral encephalitis and treated with antiviral medicine, antibiotics and mannitol, but he was in sustained unconsciousness and weak in expectorating. The patient was given oxygen through artificial nasal after bedside tracheotomy. At 1:00 am on January 12th, 2016, there was a sudden drop in blood pressure, heart rate and oxygen saturation with left lung breath sounds slightly lower than the other side...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29628695/medical-textiles-in-orthopedics-an-overview
#2
REVIEW
Raju Vaishya, Amit Kumar Agarwal, Manish Tiwari, Abhishek Vaish, Vipul Vijay, Yash Nigam
The use of textile in the medical field is not new; this has given rise to a new branch known as medical textiles. These are being used to repair or replace various other musculoskeletal tissues. The most common uses of biomaterials are to create aseptic conditions for protection, general health care, and hygiene including bedding and clothing, surgical gowns, face masks, head and shoe covers, sterilization wraps, suture anchors, fiber cast and braces/orthotics. These are also used as materials for preparation of wipes, swabs, wound dressings, bandages, gauzes, plasters, pressure garments, orthopedic belts and for new applications, such as heart valves, vascular grafts, artificial veins, artificial ligaments, artificial joints, artificial skin, and artificial cartilage...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628472/hcn4-overexpressing-mouse-embryonic-stem-cell-derived-cardiomyocytes-generate-a-new-rapid-rhythm-in-rats-with-bradycardia
#3
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F Kusano, Hiroshi Ito
A biological pacemaker is expected to solve the persisting problems of an artificial cardiac pacemaker including short battery life, lead breaks, infection, and electromagnetic interference. We previously reported HCN4 overexpression enhances pacemaking ability of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) in vitro. However, the effect of these cells on bradycardia in vivo has remained unclear. Therefore, we transplanted HCN4-overexpressing mESC-CMs into bradycardia model animals and investigated whether they could function as a biological pacemaker...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29623383/-mechanical-circulatory-support-in-terminal-heart-failure
#4
REVIEW
M Derwall, A Moza, A Brücken
BACKGROUND: After exhaustion of all conservative measures in the treatment of acute and chronic heart insufficiency, there is the possibility to temporarily or permanently support or replace the pump performance of the heart by mechanical circulatory support (MCS) systems. OBJECTIVE: Presentation of the most important cardiac support systems for intensive care medicine, their indications and important risk factors. MATERIAL AND METHODS: Critical review of device manufacturer's specifications, current research and expert opinions...
April 5, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29616367/anatomical-study-of-the-cleveland-clinic-continuous-flow-total-artificial-heart-in-adult-and-pediatric-configurations
#5
Kiyotaka Fukamachi, Jamshid H Karimov, Nicole A Byram, Gengo Sunagawa, Raymond Dessoffy, Takuma Miyamoto, David J Horvath
The purpose of this study was to assess the smallest possible body sizes of patients in whom the Cleveland Clinic continuous-flow total artificial heart for adult (CFTAH) and pediatric configurations (P-CFTAH) can fit. One of the most critical dimensions is the vertebra-to-sternum distance at the junction of the right atrium to the inferior vena cava (V-S distance). Our previous CFTAH anatomical fitting study suggested that the CFTAH would fit patients of V-S distance ≥ 7.5 cm and the P-CFTAH of V-S distance ≥ 5...
April 3, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29603482/3d-image-fusion-of-whole-heart-dynamic-cardiac-mr-perfusion-and-late-gadolinium-enhancement-intuitive-delineation-of-myocardial-hypoperfusion-and-scar
#6
Jochen von Spiczak, Manoj Mannil, Sebastian Kozerke, Hatem Alkadhi, Robert Manka
BACKGROUND: Since patients with myocardial hypoperfusion due to coronary artery disease (CAD) with preserved viability are known to benefit from revascularization, accurate differentiation of hypoperfusion from scar is desirable. PURPOSE: To develop a framework for 3D fusion of whole-heart dynamic cardiac MR perfusion and late gadolinium enhancement (LGE) to delineate stress-induced myocardial hypoperfusion and scar. STUDY TYPE: Prospective feasibility study...
March 30, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29602426/use-of-berlin-heart-ventricular-assist-devices-as-a-total-artificial-heart
#7
Hideyuki Kato, Sanjiv K Gandhi
No abstract text is available yet for this article.
March 8, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29596993/immune-modulation-by-silencing-cd80-and-cd86-production-in-dendritic-cells-using-small-hairpin-rna-to-reduce-heart-transplant-rejection
#8
Zhiqiang Yang, Yujian Liu, Xiaolei Zhou
RNA interference (RNAi) plays a potential role in organ transplantation. Small hairpin RNA (shRNA) is an artificial RNA molecule with a tight hairpin turn that can be used to silence the expression of a target gene. We constructed shRNA targeting on the cluster of differentiation 80 (CD80, B7-1) and the cluster of differentiation 86 (CD86, B7-2) and transfected it into dendritic cells (DCs). Fluorescence real-time PCR and flow cytometry confirmed the gene-silencing effect. Interleukin-2 (IL-2) mRNA expression level decreased in T cells that were cocultured with pB7-shRNA-transfected DCs...
March 26, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29596920/the-involvement-of-sympathetic-nervous-system-in-essence-of-chicken-facilitated-physiological-adaption-and-circadian-resetting
#9
Yinhua Ni, Lingyan Ma, Tao Wu, Ai Lin Lim, Wanjing Zhang, Luna Yang, Yoshihiro Nakao, Zhengwei Fu
AIM: The impact of the sympathetic nervous system (SNS) on the regulation of circadian rhythm and physiological functions is still not clear. Previous studies have found that essence of chicken (EC) supplementation facilitated the physiological adaption and circadian resetting in rats subjected to jet lag. Herein, the effects of SNS on the circadian clock and the hypothesis that EC-induced acceleration of circadian resetting is dependent on the SNS are investigated. MAIN METHODS: Male Wistar rats with superior cervical ganglionectomy (SCGx) were used to investigate the role of the SNS in circadian rhythm and physiological functions...
March 26, 2018: Life Sciences
https://www.readbyqxmd.com/read/29588591/immobilization-of-a-carbon-nanomaterial-based-localized-drug-release-system-using-a-bispecific-material-binding-peptide
#10
Katsutoshi Kokubun, Sachiko Matsumura, Masako Yudasaka, Sumio Iijima, Kiyotaka Shiba
Introduction: Inorganic materials are widely used in medical devices, such as artificial hearts, vessels, and joints, in stents, and as nanocarriers for drug-delivery systems. Carbon nanomaterials are of particular interest due to their biological inertness and their capability to accommodate molecules. Several attempts have been proposed, in which carbon nanomaterials are used as nanocarriers for the systemic delivery of drugs. Materials and methods: We developed a drug-delivery system in which oxidized single-walled carbon nanohorns (oxSWNHs) were immobilized on a titanium (Ti) surface using material-binding peptides to enable localized drug delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29578100/wisdom-of-artificial-crowds-feature-selection-in-untargeted-metabolomics-an-application-to-the-development-of-a-blood-based-diagnostic-test-for-thrombotic-myocardial-infarction
#11
Patrick J Trainor, Roman V Yampolskiy, Andrew P DeFilippis
INTRODUCTION: Heart disease remains a leading cause of global mortality. While acute myocardial infarction (colloquially: heart attack), has multiple proximate causes, proximate etiology cannot be determined by a blood-based diagnostic test. We enrolled a suitable patient cohort and conducted a non-targeted quantification of plasma metabolites by mass spectrometry for developing a test that can differentiate between thrombotic MI, non-thrombotic MI, and stable disease. A significant challenge in developing such a diagnostic test is solving the NP-hard problem of feature selection for constructing an optimal statistical classifier...
March 22, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29574625/the-cluster-re-6-se-8-i-6-3-penetrates-biological-membranes-drug-like-properties-for-cns-tumor-treatment-and-diagnosis
#12
Lisbell D Estrada, Elizabeth Duran, Matias Cisterna, Cesar Echeverria, Zhiping Zheng, Vincenzo Borgna, Nicolas Arancibia-Miranda, Rodrigo Ramírez-Tagle
Tumorigenic cell lines are more susceptible to [Re6 Se8 I6 ]3- cluster-induced death than normal cells, becoming a novel candidate for cancer treatment. Still, the feasibility of using this type of molecules in human patients remains unclear and further pharmacokinetics analysis is needed. Using coupled plasma optical emission spectroscopy, we determined the Re-cluster tissue content in injected mice, as a biodistribution measurement. Our results show that the Re-cluster successfully reaches different tissues, accumulating mainly in heart and liver...
March 24, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29571345/total-artificial-heart-as-rescue-therapy-for-primary-graft-failure-in-an-infant
#13
Luke A Ziegler, Sandeep Sainathan, Victor O Morell, Mahesh S Sharma
An infant unable to be weaned from cardiopulmonary bypass after orthotopic heart transplantation was cannulated for extracorporeal membrane oxygenation. During the next 3 days, allograft failure and intracardiac thrombosis necessitated cardiectomy. To provide acute mechanical circulatory support, artificial atrial chambers were constructed with Gore-Tex conduits and PediMag centrifugal pumps were connected to each by Berlin Heart EXCOR cannulae. The PediMag pumps were subsequently exchanged for 10-mL Berlin Heart EXCOR pumps...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29564151/analysis-of-trends-and-prospects-regarding-stents-for-human-blood-vessels
#14
Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo, Joon Woo Lee
Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Stents are classified into vascular and non-vascular stents...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29560553/development-of-an-off-the-shelf-tissue-engineered-sinus-valve-for-transcatheter-pulmonary-valve-replacement-a-proof-of-concept-study
#15
Sarah E Motta, Emanuela S Fioretta, Petra E Dijkman, Valentina Lintas, Luc Behr, Simon P Hoerstrup, Maximilian Y Emmert
Tissue-engineered heart valves with self-repair and regeneration properties may overcome the problem of long-term degeneration of currently used artificial prostheses. The aim of this study was the development and in vivo proof-of-concept of next-generation off-the-shelf tissue-engineered sinus valve (TESV) for transcatheter pulmonary valve replacement (TPVR). Transcatheter implantation of off-the-shelf TESVs was performed in a translational sheep model for up to 16 weeks. Transapical delivery of TESVs was successful and showed good acute and short-term performance (up to 8 weeks), which then worsened over time most likely due to a non-optimized in vitro valve design...
March 20, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29549933/antiphospholipid-antibodies-and-heart-valve-disease-in-systemic-lupus-erythematosus
#16
Daniel Ruiz, Jim C Oates, Diane L Kamen
Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE). Nested case-control study was conducted with 70 patients with SLE selected from a longitudinal database based on levels of aPL and presence or absence of valve disease by echocardiogram. Valvular abnormalities observed were regurgitation (52), other (14), artificial valves (4), stenosis (2), thickening (2) and no Libman-Sacks endocarditis (0). The mitral valve was the most commonly affected (30 abnormalities), followed by the tricuspid (20 abnormalities)...
March 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29549733/combining-deep-residual-neural-network-features-with-supervised-machine-learning-algorithms-to-classify-diverse-food-image-datasets
#17
Patrick McAllister, Huiru Zheng, Raymond Bond, Anne Moorhead
Obesity is increasing worldwide and can cause many chronic conditions such as type-2 diabetes, heart disease, sleep apnea, and some cancers. Monitoring dietary intake through food logging is a key method to maintain a healthy lifestyle to prevent and manage obesity. Computer vision methods have been applied to food logging to automate image classification for monitoring dietary intake. In this work we applied pretrained ResNet-152 and GoogleNet convolutional neural networks (CNNs), initially trained using ImageNet Large Scale Visual Recognition Challenge (ILSVRC) dataset with MatConvNet package, to extract features from food image datasets; Food 5K, Food-11, RawFooT-DB, and Food-101...
February 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29549728/cardio-supportive-devices-vrd-dcc-device-and-patches-for-advanced-heart-failure-a-review-summary-of-state-of-the-art-and-future-directions
#18
REVIEW
Muhammad Naveed, Lei Han, Ghulam Jilany Khan, Sufia Yasmeen, Reyaj Mikrani, Muhammad Abbas, Li Cunyu, Zhou Xiaohui
Congestive heart failure (CHF) is a complicated pathophysiological syndrome, leading cause of hospitalization as well as mortalities in developed countries wherein an irregular function of the heart leads to the insufficient blood supply to the body organs. It is an accumulative slackening of various complications including myocardial infarction (MI), coronary heart disease (CAD), hypertension, valvular heart disease (VHD) and cardiomyopathy; its hallmarks include hypertrophy, increased interstitial fibrosis and loss of myocytes...
March 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29546810/total-artificial-heart-implantation-in-a-young-marfan-syndrome-patient
#19
Prashant Rao, Jack B Keenan, Taufiek K Rajab, Samuel Kim, Richard Smith, Orazio Amabile, Zain Khalpey
INTRODUCTION: Cardiovascular complications represent the leading cause of morbidity and mortality in patients with Marfan syndrome. Here, we describe a unique case where a total artificial heart was implanted in a young Marfan syndrome woman. METHODS: A 22-year-old postpartum African American female with Marfan syndrome developed multiple severe valve dysfunction and biventricular failure that was refractory to medical management. She previously had a Bentall procedure for Type A aortic dissection and repair of a Type B dissection...
March 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29540261/stroke-thromboembolism-and-bleeding-in-patients-with-atrial-fibrillation-according-to-the-ehra-valvular-heart-disease-classification
#20
Arnaud Bisson, Alexandre Bodin, Nicolas Clementy, Anne Bernard, Dominique Babuty, Gregory Y H Lip, Laurent Fauchier
AIMS: We compared thromboembolic (TE) and bleeding risks in patients with atrial fibrillation (AF) according to the new 'Evaluated Heartvalves, Rheumatic or Artificial' (EHRA) valve classification. METHODS: Patients were divided into 3 categories: (i) EHRA type 1 corresponds to the previous 'valvular' AF patients, with either rheumatic mitral valve stenosis or mechanical prosthetic heart valves; (ii) EHRA type 2 includes AF patients with other valvular heart disease (VHD) and valve bioprosthesis or repair; and (iii) 'non-VHD controls' i...
March 7, 2018: International Journal of Cardiology
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