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https://www.readbyqxmd.com/read/29245181/revealing-a-new-mode-of-sensitization-induced-by-mechanical-circulatory-support-devices-impact-of-anti-at1-r-antibodies
#1
X Zhang, J Mirocha, T Aintablian, S Dimbil, J Moriguchi, F Arabia, J A Kobashigawa, N L Reinsmoen
BACKGROUND: Increased levels of angiotensin II type 1 receptor (AT1 R) antibody have been shown to be associated with allograft rejection. This study aims to determine the rate of development of antibody to AT1 R after Mechanical Circulatory Support Device (MCS) implantation, and if development of strong binding AT1 R antibodies is associated with survival. METHODS: 88 patients who had one MCS implantation were accessed based on serum availability. MCS in this cohort included pneumatic bilateral paracorporeal ventricular assist device, continuous flow left ventricular assist device, and total artificial heart...
December 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29244074/the-heart-regulates-the-endocrine-response-to-heart-failure-cardiac-contribution-to-circulating-neprilysin
#2
Mattia Arrigo, Nicolas Vodovar, Hélène Nougué, Malha Sadoune, Chris J Pemberton, Pamela Ballan, Pierre-Olivier Ludes, Nicolas Gendron, Alain Carpentier, Bernard Cholley, Philippe Bizouarn, Alain Cohen-Solal, Jagmeet P Singh, Jackie Szymonifka, Christian Latremouille, Jane-Lise Samuel, Jean-Marie Launay, Julien Pottecher, A Mark Richards, Quynh A Truong, David M Smadja, Alexandre Mebazaa
Aims: Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results: Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6...
December 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29240626/first-report-of-biventricular-percutaneous-impella-ventricular-assist-device-use-in-pediatric-patients
#3
Javier J Lasa, Daniel A Castellanos, Susan W Denfield, William J Dreyer, Sebastian C Tume, Henri Justino, Athar M Qureshi
There is a growing interest in the use of percutaneously delivered ventricular assist devices (PVAD) in the pediatric patient population. A 16 year old female and 18 year old male both status post heart transplantation presented with evidence of graft rejection and acute severe global systolic and diastolic heart failure necessitating hemodynamic catheterization and inotropic support. Both underwent percutaneous Impella CP LVAD (Abiomed, Danvers, MA) placement with close monitoring of right ventricular function...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29235399/reviewing-the-use-of-ventricular-assist-devices-in-the-elderly-where-do-we-stand-today
#4
Nandini Nair, Enrique Gongora
Implantation of left ventricular assist devices (LVADS) in older patients appears to be an attractive option in the wake of donor shortage and increasing incidence and prevalence of end stage heart failure. Since the inception of the artificial heart program half a century ago tremendous progress in research and development has led to utilization of more sophisticated devices. VADs have therefore emerged as a successful therapy for extending life with meaningful quality. Areas covered: This review will address the use of LVADS as a bridge to transplantation, destination therapy and comparison of LVAD therapy with alternate list heart transplantation in the elderly population...
December 13, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29232303/totally-endoscopic-cardiac-surgery-for-atrial-septal-defect-repair-on-beating-heart-without-robotic-assistance-in-25-patients
#5
Quang-Huy Dang, Ngoc-Thanh Le, Cong-Huu Nguyen, Dac-Dai Tran, Do-Hung Nguyen, Trung-Hieu Nguyen, Thi-Hai-Linh Ngo
OBJECTIVE: The aim of the study was to investigate the effectivity and safety of totally endoscopic cardiac surgery without robotic assistance for atrial septal defect (ASD) closure on beating hearts. METHODS: Twenty-five patients (adults/children: 15/10) underwent ASD closure using nonrobotically assisted totally endoscopic approach on beating heart. Three 5-mm trocars and one 12-mm trocar were used, only the superior vena cava is snared, filling the pleural and pericardial cavities with CO2, and the heart was beating during the surgery...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29231482/-optimal-acupoint-combination-of-transcutaneous-electrical-stimulation-in-artificial-abortion-operation
#6
Chong Chen, Wenxia Xie, Zedong Wang, Linchai Zeng, Pei Liu, Chunli Li
OBJECTIVE: To observe the clinical effects on analgesia, tranquilization and prevention of abortion syndrome of artificial abortion operation treated with transcutaneous electrical acupoint stimulation (TEAS) with different acupoint combination and explore the optimal acupoint combination of TEAS in artificial abortion operation. METHODS: Two hundred patients intended to artificial operation were randomized into No.1 group[Sanyinjiao (SP 6) + Zusanli (ST 36)], No...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29223792/prediction-of-persistent-hemodynamic-depression-after-carotid-angioplasty-and-stenting-using-artificial-neural-network-model
#7
Jin Pyeong Jeon, Chulho Kim, Byoung-Doo Oh, Sun Jeong Kim, Yu-Seop Kim
OBJECTIVES: To assess and compare predictive factors for persistent hemodynamic depression (PHD) after carotid artery angioplasty and stenting (CAS) using artificial neural network (ANN) and multiple logistic regression (MLR) or support vector machines (SVM) models. PATIENTS AND METHODS: A retrospective data set of patients (n=76) who underwent CAS from 2007 to 2014 was used as input (training cohort) to a back-propagation ANN using TensorFlow platform. PHD was defined when systolic blood pressure was less than 90mmHg or heart rate was less 50 beats/min that lasted for more than one hour...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29222320/anticoagulation-with-vads-and-ecmo-walking-the-tightrope
#8
REVIEW
Leslie Raffini
The evolution of devices for mechanical circulatory support (MCS), including ventricular assist devices (VADs) for patients with heart failure and extracorporeal membrane oxygenation (ECMO) for patients with acute cardiac or respiratory failure, has improved survival for subsets of critically ill children and adults. The devices are intricate and complex, allowing blood to bypass the heart or lungs (or both). As blood flows through these artificial devices, normal hemostasis is disrupted, coagulation is promoted, and in the absence of anticoagulation, a thrombus may form in the device, resulting in device failure or embolic stroke...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29203032/detection-and-prediction-of-driver-drowsiness-using-artificial-neural-network-models
#9
Charlotte Jacobé de Naurois, Christophe Bourdin, Anca Stratulat, Emmanuelle Diaz, Jean-Louis Vercher
Not just detecting but also predicting impairment of a car driver's operational state is a challenge. This study aims to determine whether the standard sources of information used to detect drowsiness can also be used to predict when a given drowsiness level will be reached. Moreover, we explore whether adding data such as driving time and participant information improves the accuracy of detection and prediction of drowsiness. Twenty-one participants drove a car simulator for 110min under conditions optimized to induce drowsiness...
December 1, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29198868/an-interagency-registry-for-mechanically-assisted-circulatory-support-intermacs-analysis-of-hospitalization-functional-status-and-mortality-after-mechanical-circulatory-support-in-adults-with-congenital-heart-disease
#10
Ari Cedars, Christina Vanderpluym, Devin Koehl, Ryan Cantor, Shelby Kutty, James K Kirklin
BACKGROUND: Adult congenital heart disease (ACHD) prevalence is increasing worldwide, with advanced heart failure (HF) as a leading cause of death. Limited data are available on durable mechanical circulatory support (MCS) in ACHD patients. METHODS: ACHD patients from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database were identified and propensity matched with non-ACHD patients using risk factors from the INTERMACS Seventh Annual Report...
November 17, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29196674/artificial-controlled-model-of-blood-circulation-system-for-adhesive-evaluation
#11
Sang-Myung Jung, Goo Yong Chung, Hwa Sung Shin
Since there are several casualties due to uncontrolled bleeding resulting from simple injury to surgery, effective styptic or vessel adhesives are important; however, their development is limited by the lack of standardized systems to evaluate potential compounds. The current study outlines the development of an aorta styptic evaluation system, comprising of decellularized swine aorta tissue and a heart pump-mimicking system. Although the cells in the swine aorta were removed, the structural stability of the aorta was sustained due to the maintenance of the extracellular matrix...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29191294/evolving-areas-in-heart-transplantation
#12
REVIEW
Brittany N Weber, Jon A Kobashigawa, Michael M Givertz
It has been 50 years since Dr. Christiaan Barnard performed the first human-to-human heart transplant in December 1967 in South Africa. Remarkable progress has been made since that time, including changes in surgical techniques, immunosuppression, donor and recipient selection, and post-transplant care. In this paper, we provide a perspective on the changing face of heart transplantation and highlight key evolving areas. Topics that are covered include advances in immunosuppression, screening for acute and chronic rejection, cardiac allograft vasculopathy, and ongoing advancements in cardiac replacement therapy, including xenotransplantation, stem-cell research, tissue engineering, and the total artificial heart...
December 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29163251/consumer-neuroscience-based-metrics-predict-recall-liking-and-viewing-rates-in-online-advertising
#13
Jaime Guixeres, Enrique Bigné, Jose M Ausín Azofra, Mariano Alcañiz Raya, Adrián Colomer Granero, Félix Fuentes Hurtado, Valery Naranjo Ornedo
The purpose of the present study is to investigate whether the effectiveness of a new ad on digital channels (YouTube) can be predicted by using neural networks and neuroscience-based metrics (brain response, heart rate variability and eye tracking). Neurophysiological records from 35 participants were exposed to 8 relevant TV Super Bowl commercials. Correlations between neurophysiological-based metrics, ad recall, ad liking, the ACE metrix score and the number of views on YouTube during a year were investigated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163195/members-of-bitter-taste-receptor-cluster-tas2r143-tas2r135-tas2r126-are-expressed-in-the-epithelium-of-murine-airways-and-other-non-gustatory-tissues
#14
Shuya Liu, Shun Lu, Rui Xu, Ann Atzberger, Stefan Günther, Nina Wettschureck, Stefan Offermanns
The mouse bitter taste receptors Tas2r143, Tas2r135, and Tas2r126 are encoded by genes that cluster on chromosome 6 and have been suggested to be expressed under common regulatory elements. Previous studies indicated that the Tas2r143/Tas2r135/Tas2r126 cluster is expressed in the heart, but other organs had not been systematically analyzed. In order to investigate the expression of this bitter taste receptor gene cluster in non-gustatory tissues, we generated a BAC (bacterial artificial chromosome) based transgenic mouse line, expressing CreERT2 under the control of the Tas2r143 promoter...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162279/clinical-decision-support-of-radiotherapy-treatment-planning-a-data-driven-machine-learning-strategy-for-patient-specific-dosimetric-decision-making
#15
Gilmer Valdes, Charles B Simone, Josephine Chen, Alexander Lin, Sue S Yom, Adam J Pattison, Colin M Carpenter, Timothy D Solberg
BACKGROUND AND PURPOSE: Clinical decision support systems are a growing class of tools with the potential to impact healthcare. This study investigates the construction of a decision support system through which clinicians can efficiently identify which previously approved historical treatment plans are achievable for a new patient to aid in selection of therapy. MATERIAL AND METHODS: Treatment data were collected for early-stage lung and postoperative oropharyngeal cancers treated using photon (lung and head and neck) and proton (head and neck) radiotherapy...
November 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29158992/hrv-derived-data-similarity-and-distribution-index-based-on-ensemble-neural-network-for-measuring-depth-of-anaesthesia
#16
Quan Liu, Li Ma, Ren-Chun Chiu, Shou-Zen Fan, Maysam F Abbod, Jiann-Shing Shieh
Evaluation of depth of anaesthesia (DoA) is critical in clinical surgery. Indices derived from electroencephalogram (EEG) are currently widely used to quantify DoA. However, there are known to be inaccurate under certain conditions; therefore, experienced anaesthesiologists rely on the monitoring of vital signs such as body temperature, pulse rate, respiration rate, and blood pressure to control the procedure. Because of the lack of an ideal approach for quantifying level of consciousness, studies have been conducted to develop improved methods of measuring DoA...
2017: PeerJ
https://www.readbyqxmd.com/read/29154707/objective-evaluation-of-the-systemic-effects-of-topical-application-of-1-atropine-sulfate-ophthalmic-solution-in-healthy-horses
#17
Rita F Wehrman, Anne J Gemensky-Metzler, Ashley E Zibura, Amelia B Nyhart, Heather L Chandler
OBJECTIVE To determine the safety of topical administration of 1% atropine ophthalmic solution in healthy horses by objectively measuring gastrointestinal transit time. DESIGN Randomized, masked, controlled crossover study. ANIMALS 6 adult geldings. PROCEDURES Horses were randomly assigned (3/group) to first receive topical treatment of the left eye with 1% atropine or artificial tears solution; the right eye was left untreated. After 24 hours of treatment every 6 hours, 200 nontoxic beads were administered to each horse via nasogastric intubation and treatment frequency was decreased to every 12 hours for 4 more days...
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29153213/-circulatory-assistance-an-alternative-to-heart-transplantation
#18
Jean-Christian Roussel, Thomas Sénage
Circulatory assistance is developing as a treatment for patients with end-stage heart failure. There are two alternative devices: a univentricular circulatory assist pump, or a total artificial heart. It is used to bridge the time to transplantation and, increasingly, as a definitive alternative to a heart transplant.
November 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29149978/perioperative-prophylaxis-for-total-artificial-heart-transplantation
#19
H E Chambers, P Pelish, F Qiu, D F Florescu
BACKGROUND: Practice variation regarding perioperative antimicrobial prophylaxis in total artificial heart transplantations (TAH-t) across institutions is unknown. The aim of our survey was to assess the current practices for prevention of infection in TAH-t recipients among different programs. METHODS: An electronic survey was sent to programs that implant Syncardia TAH (Syncardia Systems, Tuscon, Ariz, USA). Proportions were analyzed for categorical variables; means and SDs were analyzed for continuous variables...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29148548/acrylate-based-materials-for-heart-valve-scaffold-engineering
#20
Rosaria Santoro, Seshasailam Venkateswaran, Francesco Amadeo, Rong Zhang, Maura Brioschi, Anthony Callanan, Marco Agrifoglio, Cristina Banfi, Mark Bradley, Maurizio Pesce
Calcific aortic valve disease (CAVD) is the most frequent cardiac valve pathology. Its standard treatment consists of surgical replacement either with mechanical (metal made) or biological (animal tissue made) valve prostheses, both of which have glaring deficiencies. In the search for novel materials to manufacture artificial valve tissue, we have conducted a high-throughput screening with subsequent up-scaling to identify non-degradable polymer substrates that promote valve interstitial cells (VICs) adherence/growth and, at the same time, prevent their evolution toward a pro-calcific phenotype...
November 17, 2017: Biomaterials Science
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