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ocular pemphigoid

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https://www.readbyqxmd.com/read/29921954/incidence-clinical-features-and-diagnosis-of-cicatrising-conjunctivitis-in-australia-and-new-zealand
#1
Samantha Bobba, Connor Devlin, Nick Di Girolamo, Denis Wakefield, Peter McCluskey, Elsie Chan, Mark Daniell, Stephanie Watson
AIMS: This study aimed to determine the incidence, clinical features and management of cicatrising conjunctivitis in Australia and New Zealand, also enabling comparison with data from the United Kingdom. METHODS: A prospective surveillance study was conducted over 17 months via the Australian and New Zealand Ophthalmic Surveillance Unit with a one-year follow-up period. Practicing ophthalmologists on the Surveillance Unit's database were asked to report recently diagnosed cases of cicatrising conjunctivitis on a monthly basis...
June 19, 2018: Eye
https://www.readbyqxmd.com/read/29789014/a-review-of-scoring-systems-for-ocular-involvement-in-chronic-cutaneous-bullous-diseases
#2
REVIEW
Brendon W H Lee, Jeremy C K Tan, Melissa Radjenovic, Minas T Coroneo, Dedee F Murrell
BACKGROUND: Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity. The objectives of this report were, firstly, to document the prevalence and severity of ocular involvement in EB/AIBD...
May 22, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29780948/adrenocorticotropic-hormone-analogue-as-novel-treatment-regimen-in-ocular-cicatricial-pemphigoid
#3
Yael Sharon, David S Chu
Purpose: To report the clinical outcome of a patient with ocular cicatricial pemphigoid, treated with adrenocorticotropic hormone gel. Observations: A 75-year-old female with a biopsy proven ocular cicatricial pemphigoid (OCP) presented with bilateral conjunctival inflammation, fornix shortening, subepithelial fibrosis and corneal scarring. The patient was previously treated with topical steroids, topical cyclosporine and lubricating drops, and had undergone several amniotic membrane transplants due to recurrent corneal erosions...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780924/disseminated-nocardiosis-with-retinal-abscess-in-a-patient-treated-for-bullous-pemphigoid
#4
Sidharth Puri, Amir Hadayer, Andrea Breaux, Charles C Barr
Purpose: To report a case of disseminated Nocardiosis with retinal and intracranial lesions. Observations: A 49-year-old woman immunosuppressed because of treatment given for bullous pemphigoid presented with altered mental status and multiple intracranial lesions on imaging. The patient was found to have multiple retinal lesions in both eyes, including a subretinal abscess in the right eye. The patient underwent brain biopsy, confirming Nocardia farcinica histopathologically and in culture...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29672212/incidence-and-clinical-characteristics-of-ocular-involvement-in-mucous-membrane-pemphigoid
#5
Gloria H Hong, Irfan R Khan, Amde Selassie Shifera, Chinwenwa Okeagu, Jennifer E Thorne
PURPOSE: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement. METHODS: Retrospective chart review of 162 biopsy-proven MMP patients. RESULTS: At presentation, 109 of 162 MMP patients (67.3%) had ocular involvement and 53 patients did not. Of the 53 patients without ocular involvement at presentation followed up to 22 years, the risk of developing ocular MMP was 0...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29602451/-autologous-serum-tears-long-term-treatment-in-dry-eye-syndrome
#6
M Beylerian, M Lazaro, J Magalon, J Veran, A Darque, F Grimaud, N Stolowy, H Beylerian, F Sabatier, L Hoffart
INTRODUCTION: Dry eye disease is a multifactorial pathology of the ocular surface. The high incidence of this pathology, as well as its significant impact on quality of life and vision and its financial cost, makes it a real public health problem. While the treatment of mild cases is generally simple and effective, treatment of severe forms is often disappointing. The use of autologous serum tears (AST) represents a therapeutic alternative for the most severe cases. The purpose of our study is to evaluate the efficacy of long-term AST treatment in patients with severe dry eye disease refractory to conventional treatment or secondary to systemic diseases such as Sjögren's syndrome or Graft versus Host disease (GVH), or ocular pathologies such as neurotrophic keratitis, chemical burns and ocular cicatricial pemphigoid...
March 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29577102/a-case-with-corneal-perforation-due-to-bacterial-concretion-derived-from-lacrimal-canaliculitis
#7
Sho Ishikawa, Naoko Kato
Purpose: To report a case with corneal perforation, presumably due to ocular cicatricial pemphigoid (OCP) and bacterial concretion derived from lacrimal canaliculitis. Observations: A patient with OCP demonstrated adherence of concretion to the cornea of her right eye. She also demonstrated canaliculitis in this eye. We removed a whitish precipitate from the bottom of the corneal ulcer. When we flushed her lacrimal pathway, a marked amount of bacterial concretion and dense mucosa were refluxed from both puncta on the right side...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29547128/is-gliclazide-a-new-antidiabetic-drug-implicated-in-the-pathogenesis-of-ocular-mucous-membrane-pemphigoid
#8
Emanuele Cozzani, Giovanni Di Zenzo, Margherita Cioni, Sanja Javor, Marco Altieri, Luca Anselmi, Aurora Parodi
No abstract text is available yet for this article.
March 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29524251/a-case-of-subepidermal-autoimmune-bullous-disease-with-autoantibodies-against-200-and-290-kda-antigens
#9
LETTER
M Sawada, T Hida, H Ujiie, H Iwata, H Uhara
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29517945/management-of-ocular-cicatricial-pemphigoid-with-intravenous-immunoglobulin-monotherapy
#10
Lina Ma, Caiyun You, Mikhail Hernandez, Arash Maleki, Andres Lasave, Alexander Schmidt, Andrew Stephenson, Thongzen Zhao, Stephen Anesi, C Stephen Foster
PURPOSE: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP). METHODS: A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. IVIg infusion was 2g/kg/cycle administered in 3 consecutive days monthly. RESULTS: Of 512 OCP patients, 17 patients (34 eyes) treated with IVIg monotherapy were identified...
March 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29378178/limbal-stem-cell-deficiency-demography-and-underlying-causes
#11
Jayesh Vazirani, Dhanyasree Nair, Swapna Shanbhag, Siva Wurity, Abhishek Ranjan, Virender Sangwan
PURPOSE: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD. DESIGN: Retrospective, multicenter case series. SETTING: Two large tertiary care ophthalmology hospitals. SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014. METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed...
April 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#12
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29341971/atopy-in-patients-with-ocular-cicatricial-pemphigoid
#13
Nazanin Ebrahimiadib, Mikhail Hernandez, Bobeck S Modjtahedi, C Ramak Roohipoor, C Stephen Foster
PURPOSE: To evaluate the presence of atopy in patients with ocular cicatricial pemphigoid (OCP). METHOD: Patient encounters between August 2005 and November 2016 at the Massachusetts Eye Research and Surgery Institute (MERSI) were searched to identify those with biopsy-proven OCP who had concurrent evidence of atopy. RESULTS: There were 230 patients with biopsy-proven OCP. Thirty-three of them were found to have clinical symptoms of atopy (asthma, hay fever, and eczema) and of these, 23 had evidence of atopy in their conjunctival biopsy specimens...
January 16, 2018: Cornea
https://www.readbyqxmd.com/read/29217149/mucous-membrane-pemphigoid-with-ocular-involvement-the-clinical-phenotype-and-its-relationship-to-direct-immunofluorescence-findings
#14
Hon Shing Ong, Jane F Setterfield, Darwin C Minassian, John K Dart
PURPOSE: This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP...
April 2018: Ophthalmology
https://www.readbyqxmd.com/read/29210839/cataract-surgery-in-ocular-surface-diseases-clinical-challenges-and-outcomes
#15
REVIEW
Virender S Sangwan, Swati Gupta, Shilpa Das
PURPOSE OF REVIEW: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. RECENT FINDINGS: Ocular surface diseases are commonly associated with corneal scarring and vascularization, conjunctival inflammation, symblepharon and forniceal shortening...
January 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29079272/modulation-of-fibroblasts-in-conjunctival-wound-healing
#16
REVIEW
Mark Zada, Ushasree Pattamatta, Andrew White
Modulating conjunctival wound healing has the potential to improve outcomes after glaucoma filtration surgery and for several ocular disorders, including ocular cicatrial pemphigoid, vernal keratoconjunctivitis, and pterygium. Although anti-inflammatories and antimetabolites have been used with success, these nonspecific agents are not without their complications. The search for novel and more targeted means to control conjunctival fibrosis without such limitations has brought much attention to the regulation of fibroblast proliferation, differentiation, extracellular matrix production, and apoptosis...
February 2018: Ophthalmology
https://www.readbyqxmd.com/read/29077176/long-term-remission-of-ocular-cicatricial-pemphigoid-off-immunomodulatory-therapy
#17
Caiyun You, Lina Ma, Stephen D Anesi, C Stephen Foster
PURPOSE: To evaluate whether long-term remission of ocular cicatricial pemphigoid (OCP) after withdrawal of immunomodulatory therapy (IMT) is possible. METHODS: A total of 34 of 464 presenting patients (66 eyes) with biopsy-proven OCP in long-term remission off IMT were identified after finishing a 2-year IMT regimen without active disease (2005-2015). Long-term remission off IMT for OCP was defined as patients withdrawn from IMT ≥1 year lacking clinically detectable progressive scarring according to Foster staging and subjective assessment...
October 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29066238/ocular-features-of-multiple-system-atrophy
#18
Maria D Garcia, Jose S Pulido, Elizabeth A Coon, John J Chen
The aim of this paper is to gain better understanding of the ocular manifestations of multiple system atrophy (MSA), a neurodegenerative disorder rarely studied in terms of its ophthalmologic features. We performed a retrospective case series (1/1/05-12/31/14) to search for patients seen at Mayo Clinic, Rochester, MN, who had mention of MSA in the medical record and an eye examination, which yielded 285 cases. Of the 285, we identified 39 cases of true MSA. Each of these 39 patients was further reviewed for ocular abnormalities potentially related to MSA...
January 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28988898/elevated-aqueous-cytokine-levels-in-eyes-with-ocular-surface-diseases
#19
Naohiko Aketa, Takefumi Yamaguchi, Teru Asato, Yukari Yagi-Yaguchi, Terumasa Suzuki, Kazunari Higa, Toshihide Kurihara, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases. DESIGN: Prospective consecutive case series. METHODS: This study includes 14 patients (aged 62.4 ± 13.7 years) with chronic-phase ocular surface diseases (4 with ocular cicatricial pemphigoid, 5 with chemical burns, 2 with a thermal burn, 2 with Stevens-Johnson syndrome, and 1 with exposure keratitis), 14 matched patients without ocular surface disease (controls with corneal scar), and 30 patients who underwent cataract surgery (healthy controls)...
December 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922328/minor-salivary-gland-transplantation-for-severe-dry-eyes
#20
Tais Hitomi Wakamatsu, Ana Estela Besteti Pires Ponce SantʼAnna, Priscila Cardoso Cristovam, Venâncio Avancini Ferreira Alves, Alda Wakamatsu, José Alvaro Pereira Gomes
Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness...
November 2017: Cornea
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