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https://www.readbyqxmd.com/read/29691736/metastatic-melanoma-to-the-colon-rectum-and-anus-a-50-year-experience
#1
Jin-Soo Park, Kheng-Seong Ng, Robyn P M Saw, John F Thompson, Christopher J Young
BACKGROUND: Melanoma metastatic to the large bowel (colon, rectum, and anus) is rarely diagnosed, with more than 95% of large bowel metastases identified post-mortem. The incidence, natural history, and survival rates of patients with large bowel melanoma metastases are poorly documented in the literature. OBJECTIVE: This study aimed to identify the incidence, clinical characteristics, and survival of patients with large bowel melanoma metastases. METHODS: A review was undertaken of all patients with melanoma treated over a 50-year period (1964-2014) at a tertiary referral center...
April 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29691614/catheter-embolization-of-type-ii-congenital-extrahepatic-portosystemic-shunt-with-hematochezia-a-case-series-and-review-of-the-literature
#2
Bo Zhang, Ke-Tong Wu, Lin Li, Hai-Yang Lai
Hematochezia is a rare clinical presentation of congenital extrahepatic portosystemic shunt (CEPS). We describe a series of three patients with type II CEPS presenting as hematochezia that were treated by catheter embolization, followed by a brief review of published articles. Hematochezia of the patients was due to the giant inferior mesenteric vein, superior rectal vein and colonic varices. The catheter embolization was successfully accomplished in all of the patients. After a mean follow-up of 27 months, no serious adverse effects were observed...
April 24, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29691261/serum-vancomycin-concentrations-after-oral-and-intracolonic-vancomycin-administration-in-a-patient-with-colonic-discontinuity-and-severe-clostridium-difficile-infection
#3
Katja Wilke, Sina Helbig, Katja de With
PURPOSE: A case of detectable systemic vancomycin levels after oral vancomycin administration but not after intracolonic administration in a patient with colonic discontinuity and severe Clostridium difficile infection (CDI) is reported. SUMMARY: A 63-year-old woman who had recently undergone pancreas-kidney transplantation developed severe CDI after 13 days of meropenem therapy for presumed urosepsis. Meropenem was stopped immediately, and treatment with oral vancomycin (250 mg every 6 hours) was started...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29688465/low-incidence-of-dysplasia-and-colorectal-cancer-observed-among-inflammatory-bowel-disease-patients-with-prolonged-colonic-diversion
#4
Weston Bettner, Anthony Rizzo, Steven Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Alyssa Parian, Maryam Kherad Pezhouh, Joanna Melia, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
Background: In inflammatory bowel disease (IBD), many scenarios call for fecal diversion, leaving behind defunctionalized bowel. The theoretical risk of colorectal cancer (CRC) in this segment is frequently cited as a reason for resection. To date, no studies have characterized the incidence of neoplasia in the diverted colorectal segments of IBD patients. Methods: A retrospective cohort analysis was conducted for IBD patients identified through a tertiary care center pathology database...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29687077/efficacy-and-outcomes-of-intrathecal-analgesia-as-part-of-an-enhanced-recovery-pathway-in-colon-and-rectal-surgical-patients
#5
Amit Merchea, Jenna K Lovely, Adam K Jacob, Dorin T Colibaseanu, Scott R Kelley, Kellie L Mathis, Grant M Spears, Marianne Huebner, David W Larson
Purpose: Multimodal analgesia is an essential component of an enhanced recovery pathway (ERP). An ERP that includes the use of single-injection intrathecal analgesia (IA) has been shown to decrease morbidity and cost and shorten length of stay (LOS). Limited data exist on safety, feasibility, and the optimal IA regimen. Our objective was to characterize the efficacy, safety, and feasibility of IA within an ERP in a cohort of colorectal surgical patients. Methods: We performed a retrospective review of all consecutive patients aged ≥ 18 years who underwent open or minimally invasive colorectal surgery from October 2012 to December 2013...
2018: Surgery Research and Practice
https://www.readbyqxmd.com/read/29685609/comparison-of-4-commercially-available-group-b-streptococcus-molecular-assays-using-remnant-rectal-vaginal-enrichment-broths
#6
Ryan F Relich, Rebecca J Buckner, Christopher L Emery, Thomas E Davis
The incidence of neonatal Group B streptococcal (GBS) disease has significantly declined since the widespread implementation of prenatal screening of expectant mothers for urogenital and gastrointestinal tract GBS colonization. Screening methods have evolved from exclusively culture-based approaches to more rapid and highly sensitive molecular methods. We chose to evaluate the performance of 4 commercially available GBS molecular tests for detection of GBS colonization using 299 antepartum rectal-vaginal specimens submitted to our laboratory for routine GBS screening...
March 28, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29682713/-risk-factors-of-anastomotic-leakage-after-anterior-resection-for-rectal-cancer-and-the-diagnostic-value-of-computed-tomography-signs-in-anastomotic-leakage
#7
Junling Zhang, Xiaochao Guo, Jixin Zhang, Jing Liu, Tao Wu, Pengyuan Wang, Guowei Chen, Yong Jiang, Yingchao Wu, Xin Wang
OBJECTIVE: To investigate the risk factors and computed tomography (CT) diagnostic accuracy of anastomotic leakage after resection of rectal cancer (Dixon). METHODS: This retrospective study was conducted in Peking University First Hospital from January 2013 to June 2015. A cohort of 452 patients with rectal cancer was enrolled in the study. All the patients underwent anterior resection. The relationship between clinical-pathological data (including sex, age, body mass index (BMI), presence of diabetes, hypohemoglobin (Hb<90 g/L), hypoalbuminemia (Alb<35 g/L), the distance from the lower edge of the tumors to the anus, tumor diameter, tumor differentiation, tumor TNM stage, neoadjuvant therapy status, ligation of the left colonic artery(LCA), preventive colostomy, and anastomotic leakage was analyzed retrospectively...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682709/-prevention-of-anastomotic-leakage-after-robotic-surgery-for-rectal-cancer
#8
Xiaohui Du, Xiaowei Xing
With popularity of robotic surgery system, robotic rectal cancer surgery is increasing. Precautionary measures of different perioperative periods should be taken to reduce the risk for anastomotic leakage. First, the general condition of patients should be acquainted and improved, and the risk for anastomotic leakage should be evaluated preoperatively. Preoperative neoadjuvant chemoradiotherapy may not increase the risk for anastomotic leakage after rectal surgery. The impact of routine bowel preparation to prevent anastomotic leakage needs to be verified further...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682704/-anastomotic-leakage-after-rectal-cancer-surgery-classification-and-management
#9
Pan Chi, Shenghui Huang
Many studies have focused on the identification of risk factors and prevention of anastomotic leakage following rectal cancer surgery. However, there is little knowledge regarding classification and management of anastomotic leakage in clinic. Herein, we reviewed and summarized the classification and management of anastomotic leakage after rectal cancer surgery. The relevant treatments of anastomotic leakage should be chosen based on patient's manifestation, including general and local reactions, anatomical location, and nature of the leakage (contained or free, controlled or uncontrolled leakage)...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682287/colonization-sites-in-carriers-of-esbl-producing-gram-negative-bacteria
#10
Joffrey van Prehn, Anna M Kaiser, Suzanne D van der Werff, Rosa van Mansfeld, Christina M J E Vandenbroucke-Grauls
Objective: The distribution of Extended-Spectrum Beta-Lactamase-producing Gram-negative bacteria (ESBL-GNB) colonization sites is relevant for infection control guidelines on detection and follow-up of colonization. We questioned whether it is possible to rely solely on rectal swab culture for follow-up of ESBL-GNB colonization. Methods: We retrospectively assessed ESBL-GNB colonization sites in patients in a tertiary hospital in the Netherlands. The Laboratory Information Management System was queried for all bacterial cultures obtained between January 2012 and August 2016...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#11
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29676343/histopathological-report-of-colorectal-carcinoma-resections-a-5-year-audit-in-lagos
#12
Kabir Bolarinwa Badmos, Olorunda Rotimi, Abdulrazzaq Oluwagbemiga Lawal, Adedapo O Osinowo, Mohammed Y Habeebu, Fatimah Biade Abdulkareem
Background: Complete and accurate pathology reporting of colorectal carcinoma (CRC) resection specimen is critical to clinical management of individual patients. The study aims to audit colorectal cancer histopathology reporting in Lagos between 2011 and 2015 before the adoption of the Society for Gastroenterology and Hepatology in Nigeria pro forma in 2016. Materials and Methods: All resected CRC cases were identified from the Histopathology record of our Department and that of a private Laboratory in Lagos over a 5-year from 2011 to 2015...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675892/dna-repair-protein-xpa-is-differentially-expressed-in-colorectal-cancer-and-predicts-better-prognosis
#13
Xue Feng, Jingwei Liu, Yuehua Gong, Kaihua Gou, Huaiwei Yang, Yuan Yuan, Chengzhong Xing
As an indispensable factor in DNA damage recognition step of nucleotide excision repair, XPA interacts with a series of proteins to initiate repair process. The expression characteristics of XPA in colorectal cancer (CRC) and its influence on CRC prognosis remain elusive. Tissue specimens of CRC and nontumor adjacent tissues from 283 patients were collected. XPA protein expressions were detected by immunohistochemistry staining. Nonparametric test was used to investigate the difference of XPA expression between CRC and nontumor adjacent tissues, as well as the correlation between XPA expression and clinicopathological parameters of CRC...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29668937/knockdown-of-smad7-with-a-specific-antisense-oligonucleotide-attenuates-colitis-and-colitis-driven-colonic-fibrosis-in-mice
#14
Roberta Izzo, Gerolamo Bevivino, Veronica De Simone, Silvia Sedda, Ivan Monteleone, Irene Marafini, Martina Di Giovangiulio, Angelamaria Rizzo, Eleonora Franzè, Alfredo Colantoni, Angela Ortenzi, Giovanni Monteleone
Background: In Crohn's disease (CD), the pathogenic immune response is associated with high Smad7, an inhibitor of TGF-β1 signaling. Smad7 knockdown with Mongersen, a specific antisense oligonucleotide-containing compound, restores TGF-β1 activity leading to inhibition of inflammatory signals and associates with clinical benefit in CD patients. As TGF-β1 is pro-fibrogenic, it remains unclear whether Mongersen-induced Smad7 inhibition increases the risk of intestinal fibrosis. We assessed the impact of Smad7 inhibition on the course of colitis-driven intestinal fibrosis in mice...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29667709/the-outlet-patch-gastric-heterotopia-of-the-colo-rectum-and-anus
#15
Abul Ala Syed Rifat Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam-Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth Montgomery
AIMS: Gastric heterotopia (GH) has been described throughout the gastrointestinal tract. However, the colorectal region is an extremely rare location for it. We describe the clinicopathologic features of GH of the colon, rectum, and anus. METHODS AND RESULTS: We identified 33 cases in 20 males and 13 females (median age 54 years; range, 4 months to 73 years). Sites included the rectum (N=26), anus (N=4), ileocecal junction (N=1), ascending colon (N=1) and descending colon (N=1)...
April 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#16
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29666981/an-early-life-mucosal-insult-temporarily-decreases-acute-oxazolone-induced-inflammation-in-mice
#17
Katja M Bendtsen, Peter Tougaard, Axel K Hansen
Inflammatory priming of immune cells in early life may optimize the response to a subsequent inflammatory challenge later in life. To prime the immune cells in the gut in vivo through a short inflammatory insult, we administered a low dose of dextran sulfate sodium (DSS) to 5-weeks-old BALB/c mice in the drinking water. We hypothesized that DSS-primed mice would show decreased inflammation and difference in immunological profiling, when subjected to presensitizing and oxazolone-induced colitis by rectal instillation at 9 weeks compared to non-DSS-primed control mice...
April 18, 2018: Inflammation
https://www.readbyqxmd.com/read/29666000/how-does-the-application-of-surgical-components-in-enhanced-recovery-programs-for-colorectal-surgery-change-over-time
#18
Julie Veziant, Daniel Leonard, Bruno Pereira, Karem Slim
BACKGROUND: Enhanced recovery programs (ERP) improve post-operative outcomes in proportion to how fully they are implemented. Maintaining an optimal level of application of all the ER components is thus essential. Our aim was to assess the sustainability of ER surgical components 2 years after their first implementation. METHOD: Patients undergoing elective colorectal resections were included in a prospective database. To retrospectively analyze compliance with ERP over a period of 24 months, the following components were considered: colonic preparation, surgical approach, nasogastric tube omission and absence of abdominal drainage...
April 14, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29665444/ndm-1-and-oxa-23-producing-acinetobacter-baumannii-isolated-from-intensive-care-unit-patients-in-tunisia
#19
Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker
Gastrointestinal colonization by carbapenem-resistant Acinetobacter baumannii (CRAB), is a critical step before nosocomial infection. Our objective was to evaluate CRAB intestinal carriage in patients admitted in the intensive care unit (ICU) of a Tunisian Hospital and to determine the antimicrobial resistance mechanisms involved. From December-2014 to February-2015, all 63 patients admitted at the ICU were screened for rectal CRAB-colonization upon admission and once weekly thereafter. ICU-patients who acquired a CRAB-nosocomial-infection were also included...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29663854/cyclin-dependent-kinase-1-targeting-improves-sensitivity-to-radiation-in-braf-v600e-colorectal-carcinoma-cells
#20
Girolamo Spagnoletti, Valeria Li Bergolis, Annamaria Piscazzi, Francesca Giannelli, Valentina Condelli, Lorenza Sisinni, Giuseppe Bove, Giovanni Storto, Matteo Landriscina
OBJECTIVES: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation. At present, no molecular biomarkers are available to predict response to neoadjuvant chemoradiation and select resistant tumors willing more intense therapeutic strategies. Thus, BRAF mutational status was investigated for its role in favoring resistance to radiation in colorectal carcinoma cell lines and cyclin-dependent kinase 1 as a target to improve radiosensitivity in BRAF V600E colorectal tumor cells...
April 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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