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https://www.readbyqxmd.com/read/28547933/hybrid-approach-using-laparoscopy-and-transanal-minimally-invasive-surgery-to-treat-rectal-cancer-with-invasion-to-the-seminal-vesicles
#1
Takuya Yamaguchi, Minoru Imai, Dai Uematsu
We treated a 64-year-old man for rectal cancer with direct invasion to the seminal vesicles and no distant metastases by complete resection with laparoscopy and transanal minimally invasive surgery (TAMIS). We inserted the TAMIS device into the anal canal to above the anorectal ring and dissected to prostate level. High ligation of the inferior mesenteric artery and vein was performed by standard medial laparoscopy. The sigmoid and descending colon were mobilized, and in the postrectal space, we dissected to the space made by TAMIS...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547814/electrical-stimulation-structurally-affects-the-tissues-of-the-rectum-and-anus-of-nulliparous-rats
#2
Hugo Alves de Sousa, Maria da Glória da Silva, Keyla de Paula Barbosa, Leonora Maciel de Souza Vianna, Yolanda Galindo Pacheco, José Roberto Pimenta de Godoy, Selma Aparecida Souza Kuckelhaus
Considering that the muscles of the anus perform a critical role in maintaining continence, losses in their structure can negatively affect the physiological control of the intestinal contents. Anorectal electro-stimulation (ARES) has been reported to have a positive effect on the functionality of treated patients, but how ARES affects the structural tissues of the anorectal segment remains unknown. Because the study of how ARES structurally affects human tissues is not possible, this study aimed to clarify these effects in a murine model, which has a similar anorectal segment (structure and physiology) to humans...
May 26, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28542568/nesfatin-1-like-peptide-is-a-novel-metabolic-factor-that-suppresses-feeding-and-regulates-whole-body-energy-homeostasis-in-male-wistar-rats
#3
Kavishankar Gawli, Naresh Ramesh, Suraj Unniappan
Nucleobindin-1 has high sequence similarity to nucleobindin-2, which encodes the anorectic and metabolic peptide, nesfatin-1. We previously reported a nesfatin-1-like peptide (NLP), anorectic in fish and insulinotropic in mice islet beta-like cells. The main objective of this research was to determine whether NLP is a metabolic regulator in male Wistar rats. A single intraperitoneal (IP) injection of NLP (100 μg/kg BW) decreased food intake and increased ambulatory movement, without causing any change in total activity or energy expenditure when compared to saline-treated rats...
2017: PloS One
https://www.readbyqxmd.com/read/28539683/stubborn-rectal-prolapse-in-systemic-sclerosis
#4
Sven Petersen, Alexander Tobisch, Gero Puhl, Ina Kötter, Uwe Wollina
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder. Anorectal involvement might typically cause fecal incontinence and rarely rectal prolapse. Here we report three female patients, who were admitted with a mean history of 10 years suffering from SSc. All patients presented with the initial symptom of anal incontinence, in all cases this was associated with rectal intussusception or rectal prolapse. The three women faced prolapse recurrence, independent of the initial procedure. After surgical removal of the prolapse, the incontinence remained...
2017: Reumatologia
https://www.readbyqxmd.com/read/28537946/gastrointestinal-manifestations-of-pelvic-floor-disorders-in-adolescents-a-diagnostic-framework-for-the-general-practitioner
#5
Anita Kochikar Pai, Sonia Arora Ballal
PURPOSE OF REVIEW: Pelvic floor disorders (PFDs) can present with gastrointestinal complaints in the adolescent patient, and identification of PFDs is aided by clues in the history and physical examination apparent to the knowledgeable clinician. The aim of this article is to provide a framework for the diagnostic evaluation of the adolescent patient with a PFD and introduce management strategies. RECENT FINDINGS: Patients with PFDs can present with gastrointestinal symptoms, including abdominal pain, constipation, incomplete evacuation, and fecal incontinence or nongastrointestinal complaints around genitourinary symptoms or sexual health...
May 19, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28537567/intraoperative-neuromonitoring-of-hypogastric-plexus-branches-during-surgery-for-rectal-cancer-preliminary-report
#6
Piotr Wałęga, Michał Romaniszyn, Maciej Wałęga, Jarosław Szymon Świrta, Wojciech Nowak
AIM: The aim of this study was to present our preliminary experience with intraoperative neuromonitoring during rectal resection. MATERIALS AND METHODS: We qualified 4 patients (2 women, 2 men; age 42 - 53 years) with rectal cancer for surgery with intraoperative neuromonitoring. In all patients, functional tests of the anorectal area were performed before surgery. Action potentials from the sphincter complex in response to nerve fiber stimulation were recorded with electrodes implanted before surgery...
April 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28534327/-modified-stapled-transanal-rectal-resection-combined-with-perioperative-pelvic-floor-biofeedback-therapy-in-the-treatment-of-obstructed-defecation-syndrome
#7
Lei Chen, Fanqi Meng, Tongsen Zhang, Yinan Liu, Shuang Sha, Si Chen, Jiandong Tai
OBJECTIVE: To investigate the clinical efficacy and safety of modified stapled transanal rectal resection (STARR) combined with perioperative pelvic floor biofeedback therapy (POPFBFT) in treating obstructed defecation syndrome (ODS). METHODS: Thirty female ODS patients underwent modified STARR (resection and suture was performed in rectocele with one staple) combined with POPFBFT in Department of Colorectal and Anal Surgery, The First Hospital of Jilin university from October 2013 to March 2015...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28528713/sociodemographics-and-the-impact-of-a-colostomy-to-indigent-families-and-children-with-colorectal-disorders-in-honduras
#8
W Krois, A J M Dingemans, P X Hernández, M L Metzelder, J Craniotis Rios, C A Reck-Burneo
INTRODUCTION: To describe the social impact of a colostomy on indigent families and affected children with anorectal malformations (ARM) or Hirschsprung's disease (HD) in San Pedro Sula, Honduras, we specifically targeted very low-income households that attended an international medical brigade for ARM and HD in 2016. METHODS: The impact of a colostomy on the families and children's daily life was analyzed by personal interviews with a questionnaire. RESULTS: Twenty families with children were included in the study...
May 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28528588/anorectal-swabs-as-a-marker-of-male-to-male-sexual-exposure-in-sti-surveillance-systems
#9
F H Ampt, C El Hayek, P A Agius, A L Bowring, N Bartnik, C VAN Gemert, C K Fairley, E P F Chow, C S Bradshaw, N Stephens, M S C Lim, M E Hellard
Identification of priority populations such as men who have sex with men (MSM) is important in surveillance systems to monitor trends of sexually transmitted infections (STIs). We explored using routinely collected non-behavioural data as a means to establish MSM status in surveillance by assessing anorectal swab as a marker of male-to-male sexual exposure. We used chlamydia testing data from a sexual health clinic, 2007-2012. Men reporting any male sexual partner(s) in the previous 12 months were considered MSM...
May 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28523401/functional-and-quality-of-life-outcomes-following-obstetric-anal-sphincter-injury-oasi-does-the-grade-of-injury-affect-outcomes
#10
Lisa Ramage, Clarence Yen, Shengyang Qiu, Constantinos Simillis, Christos Kontovounisios, Paris Tekkis, Emile Tan
INTRODUCTION AND HYPOTHESIS: The aim of this study was to compare functional and quality of life data in patients with increasing grades of obstetric anal sphincter injury (OASI) presenting to a tertiary colorectal pelvic floor clinic within 24 months of delivery. METHODS: Prospective data were collected from the patients for the period 2009-2016 and included data on functional outcomes and motor anorectal manometry parameters. The instruments used for the evaluation of functional outcomes were the Birmingham Bowel and Urinary Symptoms Questionnaire, the Wexner Incontinence Score, Short Form 36, and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire...
May 18, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28516189/improving-the-rigour-of-vacterl-screening-for-neonates-with-anorectal-malformations
#11
Richard John England, Bala Eradi, Govind V Murthi, Jonathan Sutcliffe
PURPOSE: Screening investigations for the vertebral, anorectal, cardiac, tracheo-oesophageal, renal and limb (VACTERL) association form an important part of the management of neonates with anorectal malformations (ARMs). We developed a proforma to define investigations and indications for referral. The aim of the current study was to determine if the proforma could improve screening rigour. METHODS: Four centres performed a 3-year retrospective audit of neonates with ARM...
May 17, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28506816/ghrelin-suppresses-cholecystokinin-cck-peptide-yy-pyy-and-glucagon-like-peptide-1-glp-1-in-the-intestine-and-attenuates-the-anorectic-effects-of-cck-pyy-and-glp-1-in-goldfish-carassius-auratus
#12
Ayelén Melisa Blanco, Juan Ignacio Bertucci, Ana Isabel Valenciano, María Jesús Delgado, Suraj Unniappan
Ghrelin is an important gut-derived hormone with an appetite stimulatory role, while most of the intestinal hormones, including cholecystokinin (CCK), peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), are appetite-inhibitors. Whether these important peptides with opposing roles on food intake interact to regulate energy balance in fish is currently unknown. The aim of this study was to characterize the putative crosstalk between ghrelin and CCK, PYY and GLP-1 in goldfish (Carassius auratus). We first determined the localization of CCK, PYY and GLP-1 in relation to ghrelin and its main receptor GHS-R1a (growth hormone secretagogue 1a) in the goldfish intestine by immunohistochemistry...
May 18, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28505117/hiv-enhancing-and-hiv-inhibiting-properties-of-cationic-peptides-and-proteins
#13
REVIEW
Alexander M Cole, Amy L Cole
Cationic antimicrobial peptides and proteins have historically been ascribed roles in innate immunity that infer killing of microbial and viral pathogens and protection of the host. In the context of sexually transmitted HIV-1, we take an unconventional approach that questions this paradigm. It is becoming increasingly apparent that many of the cationic polypeptides present in the human genital or anorectal mucosa, or human semen, are capable of enhancing HIV-1 infection, often in addition to other reported roles as viral inhibitors...
May 15, 2017: Viruses
https://www.readbyqxmd.com/read/28501111/laparoscopic-dissection-and-division-of-distal-fistula-in-boys-with-rectourethral-fistula
#14
Chen Wang, Mei Diao, Long Li, Shuli Liu, Zheng Chen, Xu Li, Wei Cheng
BACKGROUND: Congenital rectourethral fistula (RUF) is the most common form of anorectal malformations found in boys. The aim of this study is to review our experience with dissection and division of distal fistula using laparoscopic surgery in the management of RUF, especially rectourethral bulbar fistula. METHODS: One hundred and two consecutive boys with congenital RUF who underwent conventional or single-incision laparoscopic surgery between July 2008 and June 2015 were enrolled in the study...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28494458/improvement-of-anal-function-by-adipose-derived-stem-cell-sheets
#15
Yusuke Inoue, Fumihiko Fujita, Izumi Yamaguchi, Hiroko Kinoe, Daisuke Kawahara, Yusuke Sakai, Tamotsu Kuroki, Susumu Eguchi
AIM: One of the most troublesome complications of anal preserving surgery is anal sphincter dysfunction. The aim of this study was to evaluate functional recovery after implantation of adipose-derived stem cell (ADSC) sheets, novel biotechnology, for an anal sphincter resection animal model. METHODS: Eighteen female Sprague-Dawley rats underwent removal of the nearest half of the internal and external anal sphincter muscle. Nine rats received transplantation with ADSC sheets to the resected area while the remaining rats received no transplantation...
May 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28493393/final-results-of-a-european-multi-centre-prospective-observational-study-of-permacol-%C3%A2-collagen-paste-injection-for-the-treatment-of-anal-fistula
#16
Pasquale Giordano, Pierpaolo Sileri, Steen Buntzen, Angelo Stuto, Joseph Nunoo-Mensah, Leonardo Lenisa, Baljit Singh, Ole Thorlacius-Ussing, Ben Griffiths, Dorin Ziyaie
AIM: Permacol(™) collagen paste (Permacol(™) paste) is an acellular cross-linked porcine dermal collagen matrix suspension for use in soft tissue repair. The use of Permacol(™) paste in the filling of anorectal fistula tract is a new sphincter-preserving method for fistula repair. The MASERATI100 study was a prospective, observational clinical study with the objective to assess the efficacy of Permacol(™) collagen paste for anal fistula repair in 100 patients. METHOD: Patients (N=100) with anal fistula were treated at ten European surgical sites with a sphincter-preserving technique using Permacol(™) paste...
May 11, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28485050/y5-receptor-signalling-counteracts-the-anorectic-effects-of-pyy3-36-in-diet-induced-obese-mice
#17
Yan-Chuan Shi, Chi Kin Ip, Felicia Reed, David A Sarruf, Birgitte S Wulff, Herbert Herzog
Peptide YY 3-36 (PYY3-36) is known as a critical satiety factor reducing food intake both in rodents and humans. While the anorexic effect of PYY3-36 is thought to be mediated mainly by the Y2 receptor, the involvement of other Y-receptors in this process has never been conclusively resolved. Amongst them the Y5 receptor (Y5R) is the most likely candidate to also be a target for PYY3-36 which is thought to counteract the anorectic effects of Y2R activation. Here we show that short term treatment of diet induced obese WT and Y5R knockout mice (Y5KO) with PYY3-36 leads to significantly reduced food intake in both genotypes, which is more pronounced in Y5R KO mice...
May 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28484399/biochemical-benefits-diagnosis-and-clinical-risks-evaluation-of-kratom
#18
REVIEW
Dimy Fluyau, Neelambika Revadigar
BACKGROUND: Kratom (Mitragyna speciosa) is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. Kratom is also known as Thom, Thang, and Biak. Its leaves and the teas brewed from them have long been used by people in that region to manage pain and opioid withdrawal and to stave off fatigue. Kratom is actually consumed throughout the world for its stimulant effects and as an opioid substitute (in form of tea, chewed, smoked, or ingested in capsules)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28484364/energy-homeostasis-in-monotremes
#19
REVIEW
Stewart C Nicol
In 1803, the French anatomist Étienne Geoffroy Saint-Hilaire decided that the newly described echidna and platypus should be placed in a separate order, the monotremes, intermediate between reptiles and mammals. The first physiological observations showed monotremes had low body temperatures and metabolic rates, and the consensus was that they were at a stage of physiological development intermediate between "higher mammals" and "lower vertebrates." Subsequent studies demonstrated that platypuses and echidnas are capable of close thermoregulation in the cold although less so under hot conditions...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28481851/what-to-do-with-lateral-nodal-disease-in-low-locally-advanced-rectal-cancer-a-call-for-further-reflection-and-research
#20
Miranda Kusters, Andrew Slater, Rebecca Muirhead, Roel Hompes, Richard J Guy, Oliver M Jones, Bruce D George, Ian Lindsey, Neil J Mortensen, Chris Cunningham
BACKGROUND: There remains a lack of international consensus on the appropriate management of lateral nodal disease. Although the East manages this more aggressively with lateral lymph node dissections, the West aims to eradicate small-volume disease with neoadjuvant chemoradiotherapy and lateral nodal disease is not considered for routine surgical treatment. However, recent studies have shown that, despite neoadjuvant treatment, a significant number of patients with lateral nodal disease develop local recurrence in the lateral compartment after total mesorectal excision...
June 2017: Diseases of the Colon and Rectum
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