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https://www.readbyqxmd.com/read/28538466/increasing-research-capacity-in-a-safety-net-setting-through-an-academic-clinical-partnership
#1
J Margo Brooks Carthon, Sara Holland, Kerry Gamble, Helyn Rothwell, Darcy Pancir, Jim Ballinghoff, Linda Aiken
Safety net settings care for a disproportionate share of low-resource patients often have fewer resources to invest in nursing research. To address this dilemma, an academic-clinical partnership was formed in an effort to increase nursing research capacity at a safety net setting. Penn Presbyterian Medical Center and the Center for Health Outcomes and Policy Research located at the University of Pennsylvania partnered researchers and baccalaureate-prepared nurses in an 18-month research skill development program...
June 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28534539/sepsis-prophylactic-antibiotic-for-prostate-biopsy-the-carbapenem-gamble
#2
Deepak K Pruthi, Michael A Liss
No abstract text is available yet for this article.
May 23, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28531824/is-subclinical-gambling-really-subclinical
#3
Jeremiah Weinstock, Laura M April, Selmi Kallmi
Gambling disorder and substance use disorders (SUD) overlap in terms of etiology and diagnostic constructs (e.g., preoccupation, loss of control), yet diagnostic thresholds for the disorders are different. Currently, endorsing 2-3 gambling disorder criteria does not warrant a diagnosis while endorsing 2-3 SUD criteria does. The aim of this study was to examine whether subclinical gamblers (i.e., endorsing 2-3 gambling disorder criteria) experience psychosocial dysfunction equivalent to individuals who are diagnosed with mild severity SUD (i...
May 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28528231/neurocognitive-dysfunction-in-problem-gamblers-with-co-occurring-antisocial-personality-disorder
#4
Austin W Blum, Eric W Leppink, Jon E Grant
OBJECTIVES: Problem gamblers with symptoms of antisocial personality disorder (ASPD) may represent a distinct problem gambling subtype, but the neurocognitive profile of individuals affected by both disorders is poorly characterized. METHOD: Non-treatment-seeking young adults (18-29years) who gambled ≥5 times in the preceding year were recruited from the general community. Problem gamblers (defined as those meeting ≥1 DSM-5 diagnostic criteria for gambling disorder) with a lifetime history of ASPD (N=26) were identified using the Mini International Neuropsychiatric Interview (MINI) and compared with controls (N=266) using questionnaire-based impulsivity scales and objective computerized neuropsychological tasks...
May 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28527216/effects-of-healthy-aging-and-mild-cognitive-impairment-on-a-real-life-decision-making-task
#5
Marie-Theres Pertl, Thomas Benke, Laura Zamarian, Margarete Delazer
In this study, we investigated the effects of age and of mild cognitive impairment (MCI) on decision making under risk by adopting a task representing real-life health-related situations and involving complex numerical information. Moreover, we assessed the relationship of real-life decision making to other cognitive functions such as number processing, executive functions, language, memory, and attention. For this reason, we compared the performance of 19 healthy, relatively younger adults with that of 18 healthy older adults as well as the performance of the 18 healthy older adults with that of 17 patients with MCI...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28524791/sagittal-craniosynostosis-a-utility-outcomes-study
#6
Victoria Kuta, P Daniel McNeely, Simon Walling, Michael Bezuhly
OBJECTIVE Sagittal craniosynostosis results in a characteristic scaphocephalic head shape that is typically corrected surgically during a child's 1st year of life. The authors' objective was to determine the potential impact of being born with sagittal craniosynostosis by using validated health state utility assessment measures. METHODS An online utility assessment was designed to generate health utility scores for scaphocephaly, monocular blindness, and binocular blindness using standardized utility assessment tools, namely the visual analog scale (VAS) and the standard gamble (SG) and time trade-off (TTO) tests...
May 19, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28523287/modeling-risky-decision-making-in-nonhuman-animals-shared-core-features
#7
Sarah R Heilbronner
Understanding the neural mechanisms of risky decision-making is critical to developing appropriate treatments for psychiatric disorders, problem gambling, and addiction to drugs of abuse. Probing neurobiological mechanisms requires the use of nonhuman animal models (particularly rhesus macaques, rats, and mice). However, there is considerable variation across species in risk preferences. Nevertheless, there are shared core features of risky decision-making present across species. As demonstrated with a wide variety of behavioral paradigms, modulators of risk preference observed in humans are readily replicated in model species...
August 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28522387/australian-private-midwives-with-hospital-visiting-rights-in-queensland-structures-and-processes-impacting-clinical-outcomes
#8
J Fenwick, H Brittain, J Gamble
BACKGROUND: Reporting the outcomes for women and newborns accessing private midwives with visiting rights in Australia is important, especially since this data cannot currently be disaggregated from routinely collected perinatal data. AIM: 1) Evaluate the outcomes of women and newborns cared for by midwives with visiting access at one Queensland facility and 2) explore private midwives views about the structures and processes contributing to clinical outcomes. METHODS: Mixed methods...
May 15, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28521912/stressing-out-in-medieval-denmark-an-investigation-of-dental-enamel-defects-and-age-at-death-in-two-medieval-danish-cemeteries
#9
Julia A Gamble, Jesper L Boldsen, Robert D Hoppa
The influence of early life stress on later life experiences has become a major focus of research in medicine and more recently in bioarchaeology. Dental enamel, which preserves a record of childhood stress events, represents an important resource for this investigation when paired with the information from adult skeletal remains, such as age at death. The purpose of this research was to use a life history approach to the exploration of sex differences in the relationship between childhood stress and adult longevity by examining accentuated striae of Retzius (AS)...
June 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28521732/the-berlin-inventory-of-gambling-behavior-screening-big-s-validation-using-a-clinical-sample
#10
Martin Wejbera, Kai W Müller, Jan Becker, Manfred E Beutel
BACKGROUND: Published diagnostic questionnaires for gambling disorder in German are either based on DSM-III criteria or focus on aspects other than life time prevalence. This study was designed to assess the usability of the DSM-IV criteria based Berlin Inventory of Gambling Behavior Screening tool in a clinical sample and adapt it to DSM-5 criteria. METHODS: In a sample of 432 patients presenting for behavioral addiction assessment at the University Medical Center Mainz, we checked the screening tool's results against clinical diagnosis and compared a subsample of n=300 clinically diagnosed gambling disorder patients with a comparison group of n=132...
May 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28517037/serum-phosphate-is-related-to-adiposity-in-healthy-adults
#11
Emma O Billington, Greg D Gamble, Sarah Bristow, Ian R Reid
BACKGROUND: Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. METHODS: Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n=323) and healthy postmenopausal women (Female Cohort 1, n=185; and Female Cohort 2, n=1471), are reported...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28515502/ismp-adverse-drug-reactions-pregabalin-induced-stuttering-nitroglycerine-induced-bradycardia-progressing-to-asystole-minocycline-induced-dress-leading-to-liver-transplantation-and-type-1-diabetes-increased-risk-of-vertebral-fractures-in-women-receiving-thiazide
#12
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515192/study-protocol-for-a-transversal-study-to-develop-a-screening-model-for-excessive-gambling-behaviours-on-a-representative-sample-of-users-of-french-authorised-gambling-websites
#13
Bastien Perrot, Jean-Benoit Hardouin, Jean-Michel Costes, Julie Caillon, Marie Grall-Bronnec, Gaëlle Challet-Bouju
INTRODUCTION: Since the legalisation of online gambling in France in 2010, gambling operators must implement responsible gambling measures to prevent excessive gambling practices. However, actually there is no screening procedure for identifying problematic gamblers. Although several studies have already been performed using several data sets from online gambling operators, the authors deplored several methodological and clinical limits that prevent scientifically validating the existence of problematic gambling behaviour...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28514235/ondansetron-does-not-reduce-withdrawal-in-patients-with-physical-dependence-on-chronic-opioid-therapy
#14
Larry F Chu, John Sun, Anna Clemenson, Matthew J Erlendson, Tom Rico, Erika Cornell, Hannah Obasi, Zahra N Sayyid, Ellen M Encisco, Jeff Yu, Jamison G Gamble, Ian Carroll, J David Clark
OBJECTIVES: Individuals taking opioids for an extended period of time may become physically dependent, and will therefore experience opioid withdrawal should they stop taking the medication. Previous work in animal and human models has shown that the serotonin (5-HT3) receptor may be implicated in opioid withdrawal. In this study, we investigated if ondansetron, a 5-HT3-receptor antagonist, could reduce the symptoms of opioid withdrawal after chronic opioid exposure in humans. METHODS: In this double-blinded, randomized, crossover study, 33 chronic back pain patients (N = 33) were titrated onto sustained-release oral morphine for 30 days...
May 16, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28514026/gambling-with-life-masculinity-risk-and-danger-in-the-lives-of-unauthorized-migrant-roofers
#15
Sergio Chávez, Claire E Altman
BACKGROUND: This paper examines the occupational experiences of unauthorized immigrants employed in one of the most dangerous occupations in the United States: roofing. METHODS: We draw on 40 in-depth interviews with return migrants in Guanajuato, Mexico, to examine how the adoption of masculinity, dangerous working conditions, the labor market structure, and absence of legal status exacerbates injuries for unauthorized roofers. FINDINGS: Undocumented men return to Mexico injured with chronic pain, health complications, and trauma...
June 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28511259/impulse-control-disorders-and-related-complications-of-parkinson-s-disease-therapy
#16
Alexander M Lopez, Daniel Weintraub, Daniel O Claassen
Impulsive and compulsive behaviors in Parkinson's disease (PD) patients are most often attributed to dopamine agonist therapy; dysregulation of the mesocorticolimbic system accounts for this behavioral phenotype. The clinical presentation is commonly termed impulse control disorder (ICD): Behaviors include hypersexuality, compulsive eating, shopping, pathological gambling, and compulsive hobby participation. However, not all PD individuals taking dopamine agonists develop these behavioral changes. In this review, the authors focus on the similarities between the phenotypic presentation of ICDs with that of other reward-based behavioral disorders, including binge eating disorder, pathological gambling, and substance use disorders...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28506749/minority-college-students-hpv-knowledge-awareness-and-vaccination-history
#17
Sande Gracia Jones, Kayla Mathis-Gamble, Eric A Fenkl
No abstract text is available yet for this article.
April 26, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28504875/selection-of-natural-peptide-ligands-for-copper-catalyzed-azide-alkyne-cycloaddition-catalysis
#18
Allison G Aioub, Lindsay Dahora, Kelly Gamble, M G Finn
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a powerful tool for making connections in both organic reactions and biological systems. However, the use of this ligation process in living cells is limited by the toxicity associated with unbound copper ions. As an initial attempt to create peptide-based accelerating ligands capable of cellular expression, we performed synthesis and selection for such species on solid-phase synthesis beads bearing both candidate ligand and alkyne substrate...
May 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28503138/enhanced-feedback-related-negativity-in-alzheimer-s-disease
#19
Eri Nitta, Keiichi Onoda, Fuminori Ishitobi, Ryota Okazaki, Seiji Mishima, Atsushi Nagai, Shuhei Yamaguchi
Alzheimer's disease (AD), the most common cause of dementia in the elderly, results in the impairment of executive function, including that of performance monitoring. Feedback-related negativity (FRN) is an electrophysiological measure reflecting the activity of this monitoring system via feedback signals, and is generated from the anterior cingulate cortex. However, there have been no reports on FRN in AD. Based on prior aging studies, we hypothesized that FRN would decrease in AD patients. To assess this, FRN was measured in healthy individuals and those with AD during a simple gambling task involving positive and negative feedback stimuli...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28500448/bone-loss-after-denosumab-only-partial-protection-with-zoledronate
#20
Ian R Reid, Anne M Horne, Borislav Mihov, Gregory D Gamble
A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) in the spine increased 18.5% (P = 0.006), and total hip BMD by 6.9% (P = 0.03). Post-zoledronate BMDs were measured 18-23 months after treatment, and there were significant declines at each site (P spine = 0.043, P hip = 0.005). Spine BMD remained significantly above the pre-denosumab baseline (+9...
May 13, 2017: Calcified Tissue International
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