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https://www.readbyqxmd.com/read/28922261/the-effect-of-gluten-free-diet-on-clinical-symptoms-and-the-intestinal-mucosa-of-patients-with-potential-celiac-disease
#1
Roberta Mandile, Valentina Discepolo, Serena Scapaticci, Maria Rosaria Del Vecchio, Maria Antonia Maglio, Luigi Greco, Riccardo Troncone, Renata Auricchio
In this prospective study, we evaluated the effect of gluten free diet (GFD) in a cohort of 65 children with potential celiac disease (PCD). Patients received GFD for signs/symptoms (N = 47) or parents' choice (N = 18). Most frequent signs/symptoms were low Body Mass Index (BMI) (36%), recurrent abdominal pain (34%) and diarrhea (19%). Of the 35/47 patients followed-up on GFD, only 54% (19/35) showed a complete clinical response. In 9/65 patients an intestinal biopsy was also performed after at least one year of GFD...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28917107/effects-of-coffee-processing-residues-on-anaerobic-microorganisms-and-corresponding-digestion-performance
#2
Juan Pablo Rojas-Sossa, Mariana Murillo-Roos, Lidieth Uribe, Lorena Uribe-Lorio, Terence Marsh, Niels Larsen, Rui Chen, Alberto Miranda, Kattia Solís, Werner Rodriguez, Dana Kirk, Wei Liao
The objective of this study was to delineate the effects of different coffee processing residues on the anaerobic microbes and corresponding digestion performance. The results elucidated that mucilage-rich feed enhanced the accumulation of methanogens, which consequently led to better digestion performance of biogas production. Fifty percent more methane and up to 3 times more net energy (heat and electricity) output were achieved by the digestion of the mucilage-rich feed (M3). The microbial community and statistical analyses further elucidated that different residues in the feed had significant impact on microbial distribution and correspondingly influenced the digestion performance...
August 19, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28912485/serial-millisecond-crystallography-for-routine-room-temperature-structure-determination-at-synchrotrons
#3
Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S Doré, Tian Geng, Robert M Cooke, Mengning Liang, Andrea E Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O Steinmetz, Meitian Wang, Jörg Standfuss
Historically, room-temperature structure determination was succeeded by cryo-crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector and high frame-rate detector allows typical crystallographic experiments to be performed at room-temperature. Using a crystal scanning approach, we determine the high-resolution structure of the radiation sensitive molybdenum storage protein, demonstrate soaking of the drug colchicine into tubulin and native sulfur phasing of the human G protein-coupled adenosine receptor...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#4
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28901010/habitat-use-of-the-european-mudminnow-umbra-krameri-and-association-with-other-fish-species-in-a-disconnected-danube-side-arm
#5
M Sehr, H Keckeis
Fish assemblages along the longitudinal course of an old, disconnected and modified side arm of the Danube floodplain downstream of Vienna, Austria, as well as habitat structure, hydro-morphological and hydro-chemical factors, were investigated in order to analyse the key environmental determinants of the European mudminnow Umbra krameri. Generally, U. krameri was the most abundant species in the system. It occurred in disconnected ditches, ponds and pools with dense reed belts and comparatively low nutrient content, indicating its natural association with marsh habitats...
September 12, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28898599/transcriptomic-basis-of-metamorphic-competence-in-the-salt-marsh-dwelling-polychaete-capitella-teleta
#6
Robert Burns, Jan Pechenik
Marine invertebrate larvae typically take hours to weeks after being released into the plankton before becoming "competent" to metamorphose. The mechanisms that govern this transition between the precompetent and metamorphically competent states are unknown. We studied gene expression patterns in precompetent and competent larvae of the salt-marsh-dwelling polychaete worm Capitella teleta (Blake, Grassle & Eckelbarger, 2009)-a species in which precompetent larvae are unusually easy to distinguish from competent larvae-to determine differences in gene expression associated with the onset of metamorphic competence...
June 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28894523/correlation-between-cut-off-level-of-tissue-transglutaminase-antibody-and-marsh-classification
#7
Sumeet Kaur, Seema Gupta, Bela Goyal, Jasbinder Kaur
No abstract text is available yet for this article.
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28893865/roc-king-onwards-intraepithelial-lymphocyte-counts-distribution-role-in-coeliac-disease-mucosal-interpretation
#8
Kamran Rostami, Michael N Marsh, Matt W Johnson, Hamid Mohaghegh, Calvin Heal, Geoffrey Holmes, Arzu Ensari, David Aldulaimi, Brigitte Bancel, Gabrio Bassotti, Adrian Bateman, Gabriel Becheanu, Anna Bozzola, Antonio Carroccio, Carlo Catassi, Carolina Ciacci, Alexandra Ciobanu, Mihai Danciu, Mohammad H Derakhshan, Luca Elli, Stefano Ferrero, Michelangelo Fiorentino, Marilena Fiorino, Azita Ganji, Kamran Ghaffarzadehgan, James J Going, Sauid Ishaq, Alessandra Mandolesi, Sherly Mathews, Roxana Maxim, Chris J Mulder, Andra Neefjes-Borst, Marie Robert, Ilaria Russo, Mohammad Rostami-Nejad, Angelo Sidoni, Masoud Sotoudeh, Vincenzo Villanacci, Umberto Volta, Mohammad R Zali, Amitabh Srivastava
OBJECTIVES: Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens. DESIGN: The study was designed at the International Meeting on Digestive Pathology, Bucharest 2015...
September 11, 2017: Gut
https://www.readbyqxmd.com/read/28892863/mercury-in-wintering-american-black-ducks-anas-rubripes-downstream-from-a-point-source-on-the-lower-penobscot-river-maine-usa
#9
Kelsey M Sullivan, A Dianne Kopec
Waterfowl wintering along the lower Penobscot River, Maine continue to be exposed to elevated Hg concentrations from the HoltraChem chlor-alkali plant that operated along the river between 1967 and 2000. In American black ducks (Anas rubripes) total Hg in duck breast muscle increased with residence time on contaminated marshes, reaching means of 0.82±0.21μg/g ww (wet weight) by the end of the fall hunting season, and prompting Maine to issue a human consumption advisory on duck breast muscle. Methyl Hg comprised over 99% of the total Hg in breast muscle...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28892190/parasitemia-due-to-sarcocystis-neurona-like-infection-in-a-clinically-ill-domestic-cat
#10
Nina C Zitzer, Antoinette E Marsh, Mary Jo Burkhard, M Judith Radin, Maxey L Wellman, Maria Jugan, Valerie Parker
An 8-year-old, 6-kg, male neutered Domestic Shorthair cat was presented to The Ohio State University Veterinary Medical Center (OSU-VMC) for difficulty breathing. Physical examination and thoracic radiographs indicated pneumonia, a soft-tissue mass in the left caudal lung lobe, and diffuse pleural effusion. The effusion was classified as modified transudate. Rare extracellular elongated (~5-7 μm × 1-2 μm) zoites with a central round to oval-shaped purple to deep purple vesicular nucleus with coarsely stippled chromatin and light blue cytoplasm were seen on a peripheral blood smear...
September 11, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28889146/celiac-disease-in-saudi-children-evaluation-of-clinical-features-and-diagnosis
#11
Anjum Saeed, Asaad Assiri, Hebah Assiri, Anhar Ullah, Mohsin Rashid
 Objectives: To characterize the clinical presentations and diagnosis including serological tests and histopathological findings in children with celiac disease. Methods: All children (less than 18 years) with confirmed celiac disease diagnosed over a 6 year period at a private tertiary care health care center in Riyadh,  Saudi Arabia were studied retrospectively. Information collected included demographics, clinical presentation and diagnostic modalities with serology and small intestinal histology reported by Marsh grading...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28888960/complete-genome-sequence-of-endophyte-bacillus-flexus-klbmp-4941-reveals-its-plant-growth-promotion-mechanism-and-genetic-basis-for-salt-tolerance
#12
Tian-Tian Wang, Peng Ding, Pan Chen, Ke Xing, Juan-Luan Bai, Wen Wan, Ji-Hong Jiang, Sheng Qin
Bacillus flexus KLBMP 4941 is a halotolerant endophyte isolated from the halophyte Limonium sinense. This strain can improve host seedling growth under salt stress conditions. We here report the complete genome information of endophyte KLBMP 4941. It has a circular chromosome and two plasmids for a total genome 4,104,242 bp in size with a G+C content of 38.09%. Genes related to plant growth promotion (PGP), such as those associated with nitrogen fixation, siderophore, spermidine, and acetoin synthesis were found in the KLBMP 4941 genome...
September 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28883717/assessing-balance-through-the-use-of-a-low-cost-head-mounted-display-in-older-adults-a-pilot-study
#13
Santiago J Saldana, Anthony P Marsh, W Jack Rejeski, Jack K Haberl, Peggy Wu, Scott Rosenthal, Edward H Ip
INTRODUCTION: As the population ages, the prevention of falls is an increasingly important public health problem. Balance assessment forms an important component of fall-prevention programs for older adults. The recent development of cost-effective and highly responsive virtual reality (VR) systems means new methods of balance assessment are feasible in a clinical setting. This proof-of-concept study made use of the submillimeter tracking built into modern VR head-mounted displays (VRHMDs) to assess balance through the use of visual-vestibular conflict...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28883435/a-massive-tsunami-promoted-gene-flow-and-increased-genetic-diversity-in-a-near-threatened-plant-species
#14
Kako Ohbayashi, Yoshikuni Hodoki, Natsuko I Kondo, Hidenobu Kunii, Masakazu Shimada
The magnitude and frequency of disturbances affect species diversity and spatial distributions, but the direct effects of large-scale disturbances on genetic diversity are poorly understood. On March 11, 2011, the Great Tohoku Earthquake in Japan caused a massive tsunami that resulted in substantial alteration of community compositions. Populations of a near-threatened tidal marsh Carex rugulosa inhabiting brackish sandbars was also affected. We found four out of six remnant C. rugulosa populations along the Pacific Ocean had become completely extinct...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882138/a-dual-therapy-of-off-pump-temporary-left-ventricular-extracorporeal-device-and-amniotic-stem-cell-for-cardiogenic-shock
#15
Toshinobu Kazui, Phat L Tran, Tia R Pilikian, Katie M Marsh, Raymond Runyan, John Konhilas, Richard Smith, Zain I Khalpey
BACKGROUND: Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. CASE PRESENTATION: This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient...
September 7, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28881466/a-hot-lunch-for-herbivores-physiological-effects-of-elevated-temperatures-on-mammalian-feeding-ecology
#16
Phillipa K Beale, Karen J Marsh, William J Foley, Ben D Moore
Mammals maintain specific body temperatures (Tb ) across a broad range of ambient temperatures. The energy required for thermoregulation ultimately comes from the diet, and so what animals eat is inextricably linked to thermoregulation. Endothermic herbivores must balance energy requirements and expenditure with complicated thermoregulatory challenges from changing thermal, nutritional and toxicological environments. In this review we provide evidence that plant-based diets can influence thermoregulation beyond the control of herbivores, and that this can render them susceptible to heat stress...
September 7, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28875307/the-para-region-of-broad-host-range-proma-plasmids-is-a-carrier-of-mobile-genes
#17
Armando Cavalcante Franco Dias, Simone Raposo Cotta, Fernando Dini Andreote, Jan Dirk van Elsas
The ecological competences in microbiomes are driven by the adaptive capabilities present within microbiome members. Horizontal gene transfer (HGT) promoted by plasmids provides a rapid adaptive strategy to microbiomes, an interesting feature considering the constantly changing conditions in most environments. This study examined the parA locus, found in the highly promiscuous PromA class of plasmids, as the insertion site for incoming genes. A novel PCR system was designed that enabled examining insertions into this locus...
September 5, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28872635/comprehensive-analyses-of-somatic-tp53-mutation-in-tumors-with-variable-mutant-allele-frequency
#18
Alexander J Cole, Ying Zhu, Trisha Dwight, Bing Yu, Kristie-Ann Dickson, Gregory B Gard, Jayne Maidens, Susan Valmadre, Anthony J Gill, Roderick Clifton-Bligh, Deborah J Marsh
Somatic mutation of the tumor suppressor gene TP53 is reported in at least 50% of human malignancies. Most high-grade serous ovarian cancers (HGSC) have a mutant TP53 allele. Accurate detection of these mutants in heterogeneous tumor tissue is paramount as therapies emerge to target mutant p53. We used a Fluidigm Access Array™ System with Massively Parallel Sequencing (MPS) to analyze DNA extracted from 76 serous ovarian tumors. This dataset has been made available to researchers through the European Genome-phenome Archive (EGA; EGAS00001002200)...
September 5, 2017: Scientific Data
https://www.readbyqxmd.com/read/28870065/a-potential-new-threat-to-wild-life-presence-of-uv-filters-in-bird-eggs-from-a-preserved-area
#19
Daniel Molins-Delgado, Manuel Máñez, Ana Andreu, Fernando Hiraldo, Ethel Eljarrat, Damia Barcelo, M Silvia Diaz-Cruz
The present study uses bird eggs of 7 wild species as a biomonitoring tool for sunscreens occurrence. Seven UV filters (UV-Fs), including 3 hydroxy-metabolites of oxybenzone (benzophenone 3, BP3) were characterized in unhatched eggs from Doñana Natural Space (Southwestern, Spain). High frequency of detection was observed for all UV-Fs, ranging from 95% to 100%. The oxybenzone metabolite 4-hydroxybenzophenone (4HB) was ubiquitous at concentrations in the range 12.0-3,348ng g(-1) dry weight (dw). The parent compound, oxybenzone, was also present in all samples at lower concentrations (16...
September 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28869138/survival-outcomes-of-radical-prostatectomy-versus-radiotherapy-in-intermediate-risk-prostate-cancer-a-ncdb-study
#20
Sydney Marsh, Ryan W Walters, Peter T Silberstein
BACKGROUND: Studies of various prostate cancer patient cohorts found men receiving external-beam radiotherapy (EBRT) had higher mortality than men undergoing radical prostatectomy (RP). Conversely, a recent clinical trial showed no survival differences between treatment groups. We used the National Cancer Data Base (NCDB) to evaluate overall survival in intermediate-risk (T2b-T2c or Gleason 7 [grade group II or III] or prostate-specific antigen 10-20 ng/mL) prostate cancer patients undergoing EBRT with or without androgen deprivation therapy (ADT), RP, or no initial treatment...
August 9, 2017: Clinical Genitourinary Cancer
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