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https://www.readbyqxmd.com/read/28934825/the-potential-roles-of-melf-pattern-microvessel-density-and-vegf-expression-in-survival-of-patients-with-endometrioid-endometrial-carcinoma-a-morphometrical-and-immunohistochemical-analysis-of-100-cases
#1
Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam Pranjol, Daniil Rudolfovich Petrenyov, Eldar Arkadievich Nadyrov, Oleg Gennadievich Savchenko
BACKGROUND: In this study, we hypothesized that microcystic, elongated, fragmented (MELF)-pattern, vascular endothelial growth factor (VEGF) expression by cancer cells and microvessel density of cancer stroma may be associated with progression of endometrioid adenocarcinoma. METHODS: The study used data from the Belarus Cancer Registry and archival histological material of 100 patients with retrospectively known good (survival) and poor (disease progression and death) outcomes...
September 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28934822/stent-placement-for-benign-esophageal-leaks-perforations-and-fistulae-a-clinical-prediction-rule-for-successful-leakage-control
#2
Emo E van Halsema, Wouter F W Kappelle, Bas L A M Weusten, Robert Lindeboom, Mark I van Berge Henegouwen, Paul Fockens, Frank P Vleggaar, Manon C W Spaander, Jeanin E van Hooft
Background and study aims Sealing esophageal leaks by stent placement allows healing in 44 % - 94 % of patients. We aimed to develop a prediction rule to predict the chance of successful stent therapy. Patients and methods In this multicenter retrospective cohort study, patients with benign upper gastrointestinal leakage treated with stent placement were included. We used logistic regression analysis including four known clinical predictors of stent therapy outcome. The model performance to predict successful stent therapy was evaluated in an independent validation sample...
September 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28934803/two-interesting-cases-of-meralgia-paraesthetica
#3
Christopher David Jones, Luke Guiot, Mark Portelli, Timothy Bullen, Paul Skaife
Meralgia paraesthetica (MP) is a condition originally described by Bernhardt in 1878 and was eventually named by Roth in 1895. It is caused by compression of the lateral femoral cutaneous nerve (LFCN) resulting in varying types of discomfort. Severity of the symptoms can range from mildly uncomfortable to painfully disabling. In this article we discuss 2 patients with a LFCN injury occurring as a result of laparoscopic ventral rectopexy (LVR). The first patient is a 46-year-old female who reported pain and dysesthesia in the left groin and the anterolateral thigh, 2 days post LCR...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934802/intravertebral-vacuum-cleft-and-its-varied-locations-within-osteoporotic-vertebral-compression-fractures-effect-on-therapeutic-efficacy
#4
Weibo Yu, Xiaobing Jiang, De Liang, Zhensong Yao, Ting Qiu, Linqiang Ye, Shuncong Zhang, Daxiang Jin
BACKGROUND: Previous studies have reported a high incidence of re-collapse of the augmented vertebrae after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fractures (OVCFs) with intravertebral vacuum cleft (IVC) during long-term follow-up. Previous IVC might be considered an important predisposing factor for re-collapse, but the prior studies could not find a significant correlation. OBJECTIVE: To determine the incidence and distribution characteristics of IVCs and to further assess IVCs in their varied locations...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934798/clinical-course-of-cervical-percutaneous-epidural-neuroplasty-in-single-level-cervical-disc-disease-with-12-month-follow-up
#5
Chang Hyun Oh, Gyu Yeul Ji, Dong Ah Shin, Pyung Goo Cho, Seung Hwan Yoon
BACKGROUND: Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after PEN in cervical disc disease is not well-documented. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cervical PEN for single-level cervical disc disease...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934786/long-term-cost-utility-of-spinal-cord-stimulation-in-patients-with-failed-back-surgery-syndrome
#6
S Harrison Farber, Jing L Han, Aladine A Elsamadicy, Qasim Hussaini, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Shivanand P Lad
BACKGROUND: Failed back surgery syndrome (FBSS) is a cause of significant morbidity for up to 40% of patients following spine surgery, and is estimated to cost almost $20 billion. Treatment options for these patients currently include conventional medical management (CMM), repeat operation, or spinal cord stimulation (SCS). Much of the published data regarding cost effectiveness of SCS comprise smaller scale randomized controlled trials (RCTs) rather than large databases capturing practices throughout the US...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934764/assessment-of-training-capacity-in-new-zealand-general-practices-a-stocktake-in-the-lower-north-island-and-south-island
#7
Samantha A Murton, Susan Rh Pullon
AIM: General practices are providing clinically-based training for rapidly increasing numbers of medical (and other health professional) trainees. This study investigated capacity and intention of general practices to additionally teach junior doctors (now required to undertake community-based attachments by the New Zealand Medical Council) alongside current trainees in their service. METHODS: A web-based/telephone survey of all general practices was developed and administered November 2015-April 2016...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934761/comparison-between-mri-and-pathology-in-the-assessment-of-tumour-regression-grade-in-rectal-cancer
#8
Francesco Sclafani, Gina Brown, David Cunningham, Andrew Wotherspoon, Larissa Sena Teixeira Mendes, Svetlana Balyasnikova, Jessica Evans, Clare Peckitt, Ruwaida Begum, Diana Tait, Josep Tabernero, Bengt Glimelius, Susana Roselló, Janet Thomas, Jacqui Oates, Ian Chau
BACKGROUND: Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. METHODS: mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes. RESULTS: One hundred ninety-one patients were included...
September 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28934681/simultaneous-determination-of-gentiopicroside-and-its-two-active-metabolites-in-rat-plasma-by-lc-ms-ms-and-its-application-in-pharmacokinetic-studies
#9
Kai Xiong, Tingting Gao, Tong Zhang, Zhengtao Wang, Han Han
Gentiopicroside is a natural secoiridoid glycoside that may require metabolic activation to exert pharmacological effects. In this study, two active metabolites of gentiopicroside (M1 and M2) were isolated from rat urines and identified with our previous method. Most importantly, a fast, sensitive and selective ultra high-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously determine gentiopicroside and its two metabolites in rat plasma. The analytes and internal standard (swertiamarin) were separated on an ACQUITY UPLC(®) BEH C18 column (2...
September 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28934673/an-analysis-of-chemicals-and-other-constituents-found-in-produced-water-from-hydraulically-fractured-wells-in-california-and-the-challenges-for-wastewater-management
#10
Emily A Chittick, Tanja Srebotnjak
As high-volume hydraulic fracturing (HF) has grown substantially in the United States over the past decade, so has the volume of produced water (PW), i.e., briny water brought to the surface as a byproduct of oil and gas production. According to a recent study (Groundwater Protection Council, 2015), more than 21 billion barrels of PW were generated in 2012. In addition to being high in TDS, PW may contain hydrocarbons, PAH, alkylphenols, naturally occurring radioactive material (NORM), metals, and other organic and inorganic substances...
September 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934636/museum-based-programs-for-socially-isolated-older-adults-understanding-what-works
#11
Carolyn Todd, Paul M Camic, Bridget Lockyer, Linda J M Thomson, Helen J Chatterjee
This paper presents research findings that help to understand how museum programs created opportunities to enhance wellbeing and health, and changed experiences of social isolation in older adults. The research conceptualized how program elements enabled both individual experiences and relational processes to occur. These components operated within a context that was enriched by the museum as a place to support wellbeing and enhance social interaction. To meaningfully support socially isolated older people as part of local public health strategies, museums need to be accessible and engaging places that purposively support social interaction by involving people and objects, participating in multiple sessions over time, that are facilitated by skilled and knowledgeable staff...
September 18, 2017: Health & Place
https://www.readbyqxmd.com/read/28934631/picometer-scale-atom-position-analysis-in-annular-bright-field-stem-imaging
#12
Peng Gao, Akihito Kumamoto, Ryo Ishikawa, Nathan Lugg, Naoya Shibata, Yuichi Ikuhara
We study the effects of specimen mistilt on the picometer-scale measurement of local structure by combing experiment and simulation in annular bright-field scanning transmission electron microscopy (ABF-STEM). A relative distance measurement method is proposed to separate the tilt effects from the scan noise and sample drift induced image distortion. We find that under a typical experimental condition a small specimen tilt (∼6 mrad) in 25 nm thick SrTiO3 along [001] causes 11.9 pm artificial displacement between O and Sr/TiO columns in ABF image, which is more than 3 times of scan noise and sample drift induced image distortion ∼3...
September 11, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28934584/principles-and-benefits-of-explicitly-designed-medical-device-safety-architecture
#13
Brian R Larson, Paul Jones, Yi Zhang, John Hatcliff
The complexity of medical devices and the processes by which they are developed pose considerable challenges to producing safe designs and regulatory submissions that are amenable to effective reviews. Designing an appropriate and clearly documented architecture can be an important step in addressing this complexity. Best practices in medical device design embrace the notion of a safety architecture organized around distinct operation and safety requirements. By explicitly separating many safety-related monitoring and mitigation functions from operational functionality, the aspects of a device most critical to safety can be localized into a smaller and simpler safety subsystem, thereby enabling easier verification and more effective reviews of claims that causes of hazardous situations are detected and handled properly...
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28934570/htm-departments-should-operate-like-a-business-response-to-cohen
#14
Kenneth E Maddock
No abstract text is available yet for this article.
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28934568/tm-departments-should-operate-like-a-business-response-to-maddock
#15
Ted Cohen
No abstract text is available yet for this article.
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28934538/predictability-of-early-postoperative-ultrasonography-after-arthroscopic-rotator-cuff-repair
#16
Joo Han Oh, Joon Yub Kim, Sae Hoon Kim, Nam Yun Chung
The predictability of early postoperative ultrasonography (USG) for evaluating the structural integrity of repaired rotator cuffs is still unclear. The aim of this study was to compare the predictability of early USG performed 3 and 6 months postoperatively with magnetic resonance imaging (MRI) performed 1 year after arthroscopic cuff repair for structural failure. Among 213 patients who had arthroscopic rotator cuff surgery in 2013, one hundred thirty-eight patients who underwent USG between 3 and 6 months postoperatively and MRI at 1 year postoperatively were enrolled; the postoperative MRI findings were the reference standard used for the comparison...
September 21, 2017: Orthopedics
https://www.readbyqxmd.com/read/28934511/multi-drug-resistant-surgical-site-infection-due-to-mycobacterium-abscessus-complex
#17
Richa Misra, Vidhi Jain, Nidhi Tejan, Aarti Negi, Jyoti Umrao, Tapan Nirodhechand Dhole
M. abscessus complex is notoriously resistant to most antimicrobial agents. The complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. Skin and soft tissue infections due to this organism can be acquired by direct contact with contaminated material through traumatic injury, surgical wound and environmental exposure or by secondary involvement of skin/soft tissue during disseminated disease. We report a case of Mycobacterium abscessus infection recovered from a post-operative mid-line abdominal wound to illustrate the diagnostic and management difficulties encountered in such patients...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934448/cervical-spine-deformity-part-2-management-algorithm-and-anterior-techniques
#18
Lee A Tan, K Daniel Riew, Vincent C Traynelis
A sound operative plan based on solid understanding of the pathology and biomechanics is the most important part of cervical deformity correction. Many different surgical options exist for operative management of cervical spine deformities. However, selecting the correct approach that ensures the optimal clinical outcome can be challenging and often controversial. In Part 2 of this three-part review series, we discuss the pre-operative planning, management algorithm, and anterior surgical techniques for cervical deformity correction...
October 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28934394/microrna-455-3p-as-a-potential-peripheral-biomarker-for-alzheimer-s-disease
#19
Subodh Kumar, Murali Vijayan, P Hemachandra Reddy
The purpose of our study was to identify microRNAs (miRNAs) as early detectable peripheral biomarkers in Alzheimer's disease (AD). To achieve our objective, we assessed miRNAs in serum samples from AD patients and Mild cognitive impairment (MCI) subjects relative to healthy controls. We used Affymetrix microarray analysis and validated differentially expressed miRNAs using qRT-PCR. We further validated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell lines. We identified a gradual upregulation of four miRNAs: miR-455-3p, miR-4668-5p, miR-3613-3p and miR-4674...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934379/autotrophic-biorefinery-dawn-of-the-gaseous-carbon-feedstock
#20
Sai Kishore Butti, S Venkata Mohan
CO2 is a resource yet to be effectively utilized in the autotrophic biotechnology, not only to mitigate and moderate the anthropogenic influence on our climate, but also to steer CO2 sequestration for sustainable development and carbon neutral status. The atmospheric CO2 concentration has seen an exponential increase with the turn of the new millennia causing numerous environmental issues and also in a way feedstock crisis. To progressively regulate the growing CO2 concentrations and to incorporate the integration strategies to our existing CO2 capturing tools, all the influencing factors need to be collectively considered...
October 2, 2017: FEMS Microbiology Letters
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