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https://www.readbyqxmd.com/read/28329927/-lagged-effects-of-diurnal-temperature-range-on-mortality-in-66-cities-in-china-a-time-series-study
#1
Y Q Zhao, L J Wang, Y Luo, P Yin, Z J Huang, T Liu, H L Lin, J P Xiao, X Li, W L Zeng, W J Ma, M G Zhou
Objective: To estimate the effect of daily diurnal temperature range (DTR) on mortality in different areas in China. Methods: A time series study using the data collected from 66 areas in China was conducted, and Meta-analysis was used to analyze the estimates of associations between DTR and daily mortality. Modifying effects of extremely low and high DTR-mortality relationship by season and socioeconomic status (SES) were also evaluated respectively. Cumulative excess risk (CER) was used as an index to evaluate the effects...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28320857/regulation-of-very-long-acyl-chain-ceramide-synthesis-by-acyl-coa-binding-protein
#2
Natalia Santos Ferreira, Hanne Engelsby, Ditte Neess, Samuel L Kelly, Giora Volpert, Alfred H Merrill, Anthony H Futerman, Nils J Faergeman
Ceramide and more complex sphingolipids constitute a diverse group of lipids, which serve important roles as structural entities of biological membranes and as regulators of cellular growth, differentiation, and development. Thus, ceramides are vital players in numerous diseases including metabolic and cardiovascular diseases as well as neurological disorders. Here we show that acyl coenzyme A binding protein (ACBP) potently facilitates very-long acyl chain ceramide synthesis. ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold...
March 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28319722/bisphenol-s-exposure-modulate-macrophage-phenotype-as-defined-by-cytokines-profiling-global-metabolomics-and-lipidomics-analysis
#3
Chao Zhao, Zhi Tang, Jiacheng Yan, Jing Fang, Hailin Wang, Zongwei Cai
As an important structural analogue of bisphenol A (BPA), bisphenol S (BPS) has been used as alternatives to BPA in industrialized production. However, the immunotoxicity of BPS remains poorly understood. As a critical model in inflammatory responses, macrophages are used to explore the immunotoxic potential and mechanisms of BPS at environmentally relevant concentrations in our study. Here, we are combining molecular toxicology and mass spectrometry (MS)-based global metabolomics and lipidomics study together to estimate the variation of cytokines profiling and metabolism characteristic following BPS exposure...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28297799/-a-serum-lipidomic-study-of-patients-with-non-alcoholic-fatty-liver-disease
#4
R X Yang, C X Hu, Y Q Mi, W L Sun, G Y Chen, Q Pan, F Shen, G W Xu, J G Fan
Objective: To investigate the serum lipidomic profile in patients with nonalcoholic fatty liver disease (NAFLD), and to analyze the lipid metabolism characteristics of NAFLD. Methods: The subjects were divided into control group (23 patients) and pathologically confirmed NAFLD group (42 patients), and ultra-high-performance liquid chromatography-tandem mass spectrometry was used to measure serum lipidomic metabolites. The partial least squares-discriminant analysis (PLS-DA) model was established to analyze the differences in lipid metabolism with reference to the univariate analysis...
February 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28258370/characterization-and-genetic-mapping-of-the-%C3%AE-diketone-deficient-eceriferum-b-barley-mutant
#5
Qin Zhou, Chao Li, Kohei Mishina, Jiecai Zhao, Jiwei Zhang, Ruijun Duan, Xiaoying Ma, Aidong Wang, Qianxiang Meng, Takao Komatsuda, Guoxiong Chen
The barley eceriferum-b.2 (cer-b.2) mutant produces glossy leaf sheaths and is deficient in the cuticular wax component 14,16-hentriacontanedione. The mutated gene maps to a 1.3-cM interval on chromosome 3HL flanked by the genes MLOC_10972 and MLOC_69561. The cuticular wax coating of leaves and stems in many grass species is responsible for the plants' glaucous appearance. A major component of the wax is a group of β-diketone compounds. The barley eceriferum-b.2 (cer-b.2) mutant produces glossy leaf sheaths and is deficient for the compound 14,16-hentriacontanedione...
March 3, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28253529/comparative-effectiveness-research-in-musculoskeletal-imaging
#6
Shadpour Demehri, Michael P Recht, Christoph I Lee
The primary goal of comparative effectiveness research (CER) is to define the optimal choice among alternative diagnostic and interventional strategies for a given clinical scenario among major stakeholders in the health care system. In an era where health care decision makers are demanding greater evidence of improved patient outcomes from the use of medical technologies, musculoskeletal (MSK) imagers must be more engaged in generating quality CER. We provide an overview of CER and its expanding role in U...
February 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28251853/uplc-qqq-ms-based-lipidomics-approach-to-characterize-lipid-alterations-in-inflammatory-macrophages
#7
Jae Won Lee, Hyuck Jun Mok, Dae-Young Lee, Seung Cheol Park, Geum-Soog Kim, Seung-Eun Lee, Young-Seob Lee, Kwang Pyo Kim, Hyung Don Kim
In this study, UPLC-QqQ/MS-based lipidomics was applied to profile various lipids from RAW264.7 macrophages treated with different concentrations of lipopolysaccharide (LPS). The degree of inflammation increased with the LPS concentration. To elucidate the altered lipid metabolism of inflammatory macrophages, we targeted to analyze 25 lipid classes from LPS-treated RAW264.7 cells. As a result, 523 lipid species were successfully profiled by using the optimal UPLC and MRM. Statistical data analyses such as PCA, PLS-DA, and HCA differentiated five RAW264...
March 2, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28235361/nanoporous-polymer-films-of-cyanate-ester-resins-designed-by-using-ionic-liquids-as-porogens
#8
Alexander Fainleib, Alina Vashchuk, Olga Starostenko, Olga Grigoryeva, Sergiy Rogalsky, Thi-Thanh-Tam Nguyen, Daniel Grande
Novel nanoporous film materials of thermostable cyanate ester resins (CERs) were generated by polycyclotrimerization of dicyanate ester of bisphenol E in the presence of varying amounts (from 20 to 40 wt%) of an ionic liquid (IL), i.e., 1-heptylpyridinium tetrafluoroborate, followed by its quantitative extraction after complete CER network formation. The completion of CER formation and IL extraction was assessed using gel fraction content determination, FTIR, (1)H NMR, and energy-dispersive X-ray spectroscopy (EDX)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28230380/effects-of-6-hydroxyceramides-on-the-thermotropic-phase-behavior-and-permeability-of-model-skin-lipid-membranes
#9
Andrej Kováčik, Michaela Šilarová, Petra Pullmannová, Jaroslav Maixner, Kateřina Vávrová
Ceramides (Cer) based on 6-hydroxysphingosine are important components of the human skin barrier, the stratum corneum. Although diminished concentrations of 6-hydroxyCer have been detected in skin diseases such as atopic dermatitis, our knowledge on these unusual sphingolipids, which have only been found in the skin, is limited. In this work, we investigate the biophysical behavior of N-lignoceroyl-6-hydroxysphingosine (Cer NH) in multilamellar lipid membranes composed of Cer/free fatty acids (FFAs) (C16-C24)/cholesterol/cholesteryl sulfate...
March 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28225091/phase-separation-in-ceramide-np-containing-lipid-model-membranes-neutron-diffraction-and-solid-state-nmr
#10
Annett Schroeter, Sören Stahlberg, Barbora Školová, Stefan Sonnenberger, Adina Eichner, Daniel Huster, Kateřina Vávrová, Thomas Hauß, Bodo Dobner, Reinhard H H Neubert, Alexander Vogel
The stratum corneum is the outermost layer of the skin and protects the organism against external influences as well as water loss. It consists of corneocytes embedded in a mixture of ceramides, fatty acids, and cholesterol in a molar ratio of roughly 1 : 1 : 1. The unique structural and compositional arrangement of these stratum corneum lipids is responsible for the skin barrier properties. Many studies investigated the organization of these barrier lipids and, in particular, the exact conformation of ceramides...
February 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28213743/development-of-cer-001-preclinical-dose-selection-through-to-phase-i-clinical-findings
#11
Constance H Keyserling, Ronald Barbaras, Renee Benghozi, Jean-Louis Dasseux
BACKGROUND: CER-001 comprises recombinant human apolipoprotein A-I complexed with phospholipids that mimics natural, nascent, pre-β high-density lipoprotein (HDL). We present animal model data showing dose-dependent increases in cholesterol efflux with CER-001 and its subsequent elimination by reverse lipid transport, together with inhibition of atherosclerotic plaque progression. We report the first phase I study results with CER-001 in humans, starting at 0.25 mg/kg, which is 1/80th of the safe dose (20 mg/kg) established in 4-week multiple-dose animal studies dosed every second day...
February 17, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28213406/mitochondria-regulated-formation-of-endothelial-extracellular-vesicles-shifts-the-mediator-of-flow-induced-vasodilation
#12
Julie K Freed, Matthew J Durand, Brian Robert Hoffmann, John C Densmore, Andrew S Greene, David D Gutterman
In order to examine the effect of endothelial-derived extracellular vesicles (eEVs) on the mechanism of flow-induced dilation (FID) composition, formation, and functional effects on the mechanism of FID were examined from two different eEV subtypes, one produced from ceramide, the other from plasminogen-activator inhibitor 1 (PAI-1). Using videomicroscopy, internal diameter changes in response to increases in flow were measured in human adipose resistance arteries acutely exposed (30min) to eEVs derived from cultured endothelial cells exposed to ceramide or PAI-1...
February 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28210705/gastric-esd-may-be-useful-as-accurate-staging-and-decision-of-future-therapeutic-strategy
#13
Ai Fujimoto, Osamu Goto, Toshihiro Nishizawa, Yasutoshi Ochiai, Joichiro Horii, Tadateru Maehata, Teppei Akimoto, Satoshi Kinoshita, Seiji Sagara, Motoki Sasaki, Toshio Uraoka, Naohisa Yahagi
Background and study aims We sometimes perform gastric endoscopic submucosal dissection (ESD) for total pathologic diagnosis when preoperative diagnosis is difficult. In the present study we analyzed the treatment outcomes and adverse events of diagnostic ESD for early gastric cancer (EGC). Patients and methods We conducted a retrospective analysis of 18 consecutive cases of EGC in 18 patients with a suspected out-of-indication diagnosis who underwent diagnostic ESD, between June 2010 and November 2014...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28202334/synthesis-of-specifically-deuterated-ceramide-ap-c18-and-its-biophysical-characterization-using-neutron-diffraction
#14
Stefan Sonnenberger, Adina Eichner, Thomas Hauß, Annett Schroeter, Reinhard H H Neubert, Bodo Dobner
The very heterogeneous group of ceramides is known to be mandatory for proper barrier functions of the outermost layer of mammalian skin, referred to as stratum corneum (SC). The synthesis of a specifically deuterated ceramide [AP]-C18 variant is described. The synthesized ceramide contains the racemic forms of the α hydroxy fatty acid. For the biophysical implementation, the received diastereomeric ceramide was applied in a neutron diffraction experiment. Therefore, a SC lipid model membrane was prepared containing the described ceramide (CER), cholesterol (CHOL), stearic acid (SA), and cholesterol sulfate (ChS) in a ratio of 55/25/15/5wt%...
February 12, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28196533/assessment-of-complementary-feeding-of-canadian-infants-effects-on-microbiome-oxidative-stress-a-randomized-controlled-trial
#15
Wafaa Qasem, Meghan B Azad, Zakir Hossain, Elnaz Azad, Sarah Jorgensen, Sandra Castillo San Juan, Chenxi Cai, Ehsan Khafipour, Trust Beta, L Jackson Roberts, James Friel
BACKGROUND: The World Health Organization recommends exclusive breastfeeding until 6 months followed by introduction of iron-rich complementary foods (CFs). The aim of this study was to determine the impact of different iron-rich CFs on infant gut inflammation and microbiota. METHODS: Eighty-seven exclusively breastfed infants were randomly assigned to receive one of the following as their first CF: iron-fortified cereal (Cer), iron-fortified cereal with fruit (Cer + Fr), or meat (M)...
February 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28190803/characterization-of-a-novel-rhamnose-containing-acidic-glycosphingolipid-from-the-ascidian-halocynthia-aurantium
#16
Hisao Kojima, Ryota Shinohara, Saki Itonori, Masahiro Ito
Halocynthia aurantium, an edible ascidian species belonging to Urochordata, was subjected to structural characterization of acidic glycosphingolipids to investigate these molecules in ascidians: sulfatide from Ciona intestinalis and the glucuronic acid-containing acidic glycosphingolipid from H. roretzi. Acidic glycosphingolipids containing three or five sugars were isolated from soft parts of the ascidian H. aurantium by chloroform-methanol extraction, mild-alkaline hydrolysis, precipitation with cold acetone, and subsequent column chromatography using a DEAE-Sephadex A-25 column, a Florisil column, and an Iatrobead column...
February 10, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28188720/the-effect-of-non-deuterated-and-deuterated-isopropyl-myristate-on-the-thermodynamical-and-structural-behavior-of-a-2d-stratum-corneum-model-with-ceramide-ap
#17
J S L Oliveira, S Lange, B Dobner, G Brezesinski
Isopropyl myristate (IPM) is a widely used penetration enhancer in pharmaceutical formulations, however, its mechanism of action on a molecular scale is still not completely understood. Previous work using a quaternary Stratum Corneum (SC) lipid model in bulk suggested the incorporation of isopropyl myristate into the SC lipid matrix, phase separation, and perturbation of the multilamellar lipid assembly. Here, we used 2D Langmuir monolayers of a ternary SC lipid model, containing ceramide AP C18:18, stearic acid and cholesterol in a molar ratio of [1:1:0...
February 7, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28188148/analysis-of-sphingolipids-in-human-corneal-fibroblasts-from-normal-and-keratoconus-patients
#18
Hui Qi, Shrestha Priyadarsini, Sarah E Nicholas, Akhee Sarker-Nag, Jeremy Allegood, Charles E Chalfant, Nawajes A Mandal, Dimitrios Karamichos
The pathophysiology of human keratoconus (KC), a bilateral progressive corneal disease, leading to protrusion of the cornea, stromal thinning, and scarring is not well understood. In this study we investigated a novel Sphingolipid (SPL) signaling pathway through which KC may be regulated. Using human corneal fibroblasts (HCF) and human keratoconus cells (HKC) we examined the SPL pathway modulation. Both cell types were stimulated by the three TGF-β isoforms: TGF-B1 (T1), B2 (T2), and B3 (T3). All samples were analyzed using lipidomics, and real time-PCR...
February 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28183032/manganese-neurotoxicity-and-protective-effects-of-resveratrol-and-quercetin-in-preclinical-research
#19
Maciej Gawlik, Małgorzata B Gawlik, Irena Smaga, Małgorzata Filip
BACKGROUND: Exposure to Mn results in a neurological syndrome known as manganism. METHODS: We examined how 4-week Mn exposure (20mg/kg MnCl2po, 5days/week) induces neurotoxic effects in rats. Oxidized-to-reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity, vitamin E content and caspase-3 activity were measured in several rat brain structures. Further, we examined protective effects of the polyphenols: resveratrol (R) or quercetin (QCT) against Mn-induced neurotoxicity...
April 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28177564/involving-latina-o-parents-in-patient-centered-outcomes-research-contributions-to-research-study-design-implementation-and-outcomes
#20
Mónica Pérez Jolles, Maria Martinez, San Juanita Garcia, Gabriela L Stein, Kathleen C Thomas
BACKGROUND: Comparative effectiveness research (CER) is supported by policymakers as a way to provide service providers and patients with evidence-based information to make better health-care decisions and ultimately improve services for patients. However, Latina/o patients are rarely involved as study advisors, and there is a lack of documentation on how their voices contribute to the research process when they are included as collaborators. OBJECTIVES: The purpose of this article was to contribute to the literature by presenting concrete contributions of Latina/o parent involvement to study design, implementation and outcomes in the context of a CER study called Padres Efectivos (Parent Activation)...
February 8, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
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