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https://www.readbyqxmd.com/read/29345004/epidermal-permeability-barrier-function-and-sphingolipid-content-in-the-skin-of-sphingomyelin-synthase-2-deficient-mice
#1
Koji Nomoto, Yurina Itaya, Ken Watanabe, Tadashi Yamashita, Toshiro Okazaki, Yoshihiro Tokudome
BACKGROUND: Sphingomyelin synthase (SMS) is an enzyme that generates sphingomyelin (SM) from ceramide (CER) and phosphatidylcholine. SM in the epidermis is a precursor of CER, an important lipid for epidermal permeability barrier function. However, the physiological role of SMS in skin is unclear. OBJECTIVES: To uncover the function of SMS in skin, we investigated sphingolipid metabolism enzyme activity in skin, SM content in the epidermis, CER content in the stratum corneum (SC) and transepidermal water loss (TEWL) as an indicator of barrier function in SMS2-knockout (KO) mice...
January 17, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29321002/comparison-of-nuisance-parameters-in-pediatric-versus-adult-randomized-trials-a-meta-epidemiologic-empirical-evaluation
#2
Ben Vandermeer, Ingeborg van der Tweel, Marijke C Jansen-van der Weide, Stephanie S Weinreich, Despina G Contopoulos-Ioannidis, Dirk Bassler, Ricardo M Fernandes, Lisa Askie, Haroon Saloojee, Paola Baiardi, Susan S Ellenberg, Johanna H van der Lee
BACKGROUND: We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former. METHODS: In this meta-epidemiologic empirical evaluation we examined meta-analyses from the Cochrane Database of Systematic-Reviews, with at least one pediatric-RCT and at least one adult-RCT. Within each meta-analysis of binary efficacy-outcomes, we calculated the pooled-control-group event-rate (CER) across separately all pediatric and adult-trials, using random-effect models and subsequently calculated the control-group event-rate risk-ratio (CER-RR) of the pooled-pediatric-CERs vs...
January 10, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29320678/effect-of-ceramide-tail-length-on-the-structure-of-model-stratum-corneum-lipid-bilayers
#3
Timothy C Moore, Remco Hartkamp, Christopher R Iacovella, Annette L Bunge, Clare McCabe
Lipid bilayers composed of non-hydroxy sphingosine ceramide (CER NS), cholesterol (CHOL), and free fatty acids (FFAs), which are components of the human skin barrier, are studied via molecular dynamics simulations. Since mixtures of these lipids exist in dense gel phases with little molecular mobility at physiological conditions, care must be taken to ensure that the simulations become decorrelated from the initial conditions. Thus, we propose and validate an equilibration protocol based on simulated tempering, in which the simulation takes a random walk through temperature space, allowing the system to break out of metastable configurations and hence become decorrelated from its initial configuration...
January 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29310285/silver-nanoparticles-as-matrix-for-maldi-fticr-ms-profiling-and-imaging-of-diverse-lipids-in-brain
#4
Ming Guan, Zhen Zhang, Shilei Li, Jian'an Liu, Lu Liu, Hui Yang, Yangyang Zhang, Tie Wang, Zhenwen Zhao
Owing to the diversity of lipids, profiling and imaging multiple classes of lipids in one analysis by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is a great challenge. In this work, polyvinylpyrrolidone (PVP) capped silver nanoparticles (AgNPs) was used as the matrix for MALDI MSI for the first time to simultaneously analyze 10 classes of lipids from the brain. This analysis included fatty acids and their derivatives, sterols, CPAs, LPA and PAs, LPE and PEs, LPC and PCs, PS, Cers, SMs, and MAGs and DAGs, and other small metabolites...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29303361/outcomes-research-examining-treatments-quality-of-life-and-costs-in-her2-negative-and-triple-negative-metastatic-breast-cancer-a-systematic-literature-review
#5
Monika Parisi, Corey Pelletier, Dasha Cherepanov, Michael S Broder
AIM: With the aggregation of real-world data in healthcare, opportunities for outcomes research are growing. In this study, we summarize published literature examining comparative effectiveness research (CER), treatment patterns, quality of life (QoL) and costs in HER2-negative and triple-negative (TN) metastatic breast cancer (mBC). METHODS: PubMed (2010-January 2016) and four conferences (2013-January 2016) were searched using MeSH/keywords, including mBC, QoL, morbidity and therapeutics...
January 5, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29302875/sham-feeding-with-bacon-does-not-alter-transit-time-or-complete-examination-rate-during-small-bowel-capsule-endoscopy
#6
David Prichard, George Ou, Cherry Galorport, Robert Enns
BACKGROUND: During capsule endoscopy (CE) studies, the complete examination rate (CER) can be increased by prolonging capsule battery life or reducing gastric transit time (GTT) and/or small bowel transit time (SBTT). However, despite enhanced battery life, 10% of studies remain incomplete. Previously studied interventions to reduce SBTT and enhance CER have produced conflicting results. We hypothesize that this may be a consequence of an insufficiently potent stimulus of small bowel motility...
January 4, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29297991/application-of-lipidomics-to-reveal-differences-in-facial-skin-surface-lipids-between-males-and-females
#7
Le Cui, Cong-Fen He, Lin-Na Fan, Yan Jia
PURPOSE: To analyze and compare differences in facial skin surface lipids (SSL) between 18- to 25-year-old males and females. METHODS: Ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) technology was used to measure the facial SSL composition of 18- to 25-year-old males and females. Measurement results were combined with the orthogonal projections to latent structures discriminant analysis (OPLS-DA) model for analysis and comparisons, and differences in lipids with significance were selected...
January 3, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29276392/integrative-analysis-of-lncrnas-and-mirnas-with-coding-rnas-associated-with-cerna-crosstalk-network-in-triple-negative-breast-cancer
#8
Naijun Yuan, Guijuan Zhang, Fengjie Bie, Min Ma, Yi Ma, Xuefeng Jiang, Yurong Wang, Xiaoqian Hao
Triple negative breast cancer (TNBC) is a particular subtype of breast malignant tumor with poorer prognosis than other molecular subtypes. Currently, there is increasing focus on long non-coding RNAs (lncRNAs), which can act as competing endogenous RNAs (ceR-NAs) and suppress miRNA functions involved in post-transcriptional regulatory networks in the tumor. Therefore, to investigate specific mechanisms of TNBC carcinogenesis and improve treatment efficiency, we comprehensively integrated expression profiles, including data on mRNAs, lncRNAs and miRNAs obtained from 116 TNBC tissues and 11 normal tissues from The Cancer Genome Atlas...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29274292/butyrate-and-docosahexaenoic-acid-interact-in-alterations-of-specific-lipid-classes-in-differentiating-colon-cancer-cells
#9
Zuzana Tylichová, Josef Slavík, Miroslav Ciganek, Petra Ovesná, Pavel Krčmář, Nicol Straková, Miroslav Machala, Alois Kozubík, Jiřina Hofmanová, Jan Vondráček
Docosahexaenoic acid (DHA) and sodium butyrate (NaBt) exhibit a number of interactive effects on colon cancer cell growth, differentiation or apoptosis; however, the molecular mechanisms responsible for these interactions and their impact on cellular lipidome are still not fully clear. Here, we show that both dietary agents together induce dynamic alterations of lipid metabolism, specific cellular lipid classes and fatty acid composition. In HT-29 cell line, a model of differentiating colon carcinoma cells, NaBt supported incorporation of free DHA into non-polar lipids and their accumulation in cytoplasmic lipid droplets...
December 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29247062/cerr-a-single-domain-regulatory-protein-of-the-luxr-family-promotes-the-cerecidin-production-and-immunity-in-bacillus-cereus
#10
Li Zhang, Kunling Teng, Jian Wang, Zheng Zhang, Jie Zhang, Shutao Sun, Lili Li, Xiaopan Yang, Jin Zhong
Cerecidins are small lantibiotics from Bacillus cereus that were obtained using a semi-in vitro biosynthesis strategy and showed prominent antimicrobial activities against certain Gram-positive bacteria. However, the parental strain B. cereus As 1.1846 is incapable of producing cerecidins, most probably due to the transcriptional repression of the cerecidin gene cluster. Located in the cerecidin gene cluster, cerR encodes a putative response regulator protein that belongs to LuxR-family transcriptional regulators...
December 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29234684/changes-in-the-diaphragm-lipid-content-after-administration-of-streptozotocin-and-high-fat-diet-regime
#11
Bartlomiej Lukaszuk, Agnieszka Miklosz, Malgorzata Zendzian-Piotrowska, Beata Wojcik, Jan Gorski, Adrian Chabowski
The diaphragm is a dome-shaped skeletal muscle indispensable for breathing. Its activity contributes up to 70% of the total ventilatory function at rest. In comparison to other skeletal muscles, it is distinguished by an oxidative phenotype and uninterrupted cyclic contraction pattern. Surprisingly, the research regarding diaphragm diabetic phenotype particularly in the light of lipid-induced insulin resistance is virtually nonexistent. Male Wistar rats were randomly allocated into 3 groups: control, streptozotocin-induced (STZ) type-1 diabetes, and rodents fed with high-fat diet (HFD)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29228775/effects-of-ceramide-and-dihydroceramide-stereochemistry-at-c-3-on-the-phase-behavior-and-permeability-of-skin-lipid-membranes
#12
Andrej Kovacik, Petra Pullmannová, Jaroslav Maixner, Katerina Vavrova
Ceramides (Cer) are key components of the skin permeability barrier. Sphingosine-based CerNS and dihydrosphingosine-based CerNdS (dihydroCer) have two chiral centers; however, the importance of the correct stereochemistry in the skin barrier Cer is unknown. We investigated the role of the configuration at C-3 of CerNS and CerNdS in the organization and permeability of model skin lipid membranes. Unnatural L-threo-CerNS and L-threo-CerNdS with 24-C acyl chains were synthesized and, along with their natural D-erythro isomers, incorporated into membranes composed of major stratum corneum lipids (Cer, free fatty acids, cholesterol and cholesteryl sulfate)...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29216917/unexpected-profile-of-sphingolipid-contents-in-blood-and-bone-marrow-plasma-collected-from-patients-diagnosed-with-acute-myeloid-leukemia
#13
Marzena Wątek, Bonita Durnaś, Tomasz Wollny, Marcin Pasiarski, Stanisław Góźdź, Michał Marzec, Anna Chabowska, Przemysław Wolak, Małgorzata Żendzian-Piotrowska, Robert Bucki
BACKGROUND: Impaired apoptotic pathways in leukemic cells enable them to grow in an uncontrolled way. Moreover, aberrations in the apoptotic pathways are the main factor of leukemic cells drug resistance. METHODS: To assess the presence of potential abnormalities that might promote dysfunction of leukemic cells growth, HPLC system was used to determine sphingosine (SFO), sphinganine (SFA), sphingosine-1-phosphate (S1P) and ceramide (CER) concentration in the blood collected from patients diagnose with acute myeloblastic leukemia (AML; n = 49) and compare to values of control (healthily) group (n = 51)...
December 8, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29196503/sphingolipid-regulation-of-lung-epithelial-cell-mitophagy-and-necroptosis-during-cigarette-smoke-exposure
#14
Kenji Mizumura, Matthew J Justice, Kelly S Schweitzer, Sheila Krishnan, Irina Bronova, Evgeny V Berdyshev, Walter C Hubbard, Yael Pewzner-Jung, Anthony H Futerman, Augustine M K Choi, Irina Petrache
The mechanisms by which lung structural cells survive toxic exposures to cigarette smoke (CS) are not well defined but may involve proper disposal of damaged mitochondria by macro-autophagy (mitophagy), processes that may be influenced by pro-apoptotic ceramide (Cer) or its precursor dihydroceramide (DHC). Human lung epithelial and endothelial cells exposed to CS exhibited mitochondrial damage, signaled by phosphatase and tensin homolog-induced putative kinase 1 (PINK1) phosphorylation, autophagy, and necroptosis...
December 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29186823/the-subcellular-distribution-of-alpha-tocopherol-in-the-adult-primate-brain-and-its-relationship-with-membrane-arachidonic-acid-and-its-oxidation-products
#15
(no author information available yet)
The relationship between α-tocopherol, a known antioxidant, and polyunsaturated fatty acid (PUFA) oxidation, has not been directly investigated in the primate brain. This study characterized the membrane distribution of α-tocopherol in brain regions and investigated the association between membrane α-tocopherol and PUFA content, as well as brain PUFA oxidation products. Nuclear, myelin, mitochondrial, and neuronal membranes were isolated using a density gradient from the prefrontal cortex (PFC), cerebellum (CER), striatum (ST), and hippocampus (HC) of adult rhesus monkeys (n = 9), fed a stock diet containing vitamin E (α-, γ-tocopherol intake: ~0...
November 26, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29182572/aberrant-lipid-metabolism-in-hepatocellular-carcinoma-revealed-by-liver-lipidomics
#16
Zhao Li, Ming Guan, Yu Lin, Xiao Cui, Yangyang Zhang, Zhenwen Zhao, Jiye Zhu
BACKGROUND: The aim of this study was to characterize the disorder of lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. The research into the disorder of lipid metabolism in HCC is very limited. Study of lipid metabolism in liver cancer tissue may have the potential to provide new insight into HCC mechanisms. METHODS: A lipidomics study of HCC based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance mass spectrometer (MALDI-FTICR MS) was performed...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29169412/-tnf-%C3%AE-regulates-the-proliferation-of-human-breast-cancer-cells-via-regulation-of-ceramide-content
#17
Yonggang Lyu, Xin Xu, Jun Yun, Jun Yi, Xin Li, Xianghua Liu, Rui Ling, Ling Wang, Jing Fan
Objective To determine whether tumor necrosis factor α (TNF-α) regulates the proliferation of MCF-7 and MDA-MB231 cells by modifying ceramide (Cer) production. Methods The optimum dosage and time of TNF-α treatment was determined at first. Immunocytochemistry combined with confocal microcopy was adopted to measure Cer content. MCF-7 and MDA-MB231 cells were treated with TNF-α (50 ng/mL) alone or combined with the interference of ASM inhibitor, desipramine (Des) or sphingosine kinase 1 (SPHK1) inhibitor, dimethylsphingosine (DMS) to investigate the role of Cer in the proliferative regulation of TNF-α on breast cancer cells...
October 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29164179/schroth-physiotherapeutic-scoliosis-specific-exercises-for-adolescent-idiopathic-scoliosis-how-many-patients-require-treatment-to-prevent-one-deterioration-results-from-a-randomized-controlled-trial-sosort-2017-award-winner
#18
Sanja Schreiber, Eric C Parent, Doug L Hill, Douglas M Hedden, Marc J Moreau, Sarah C Southon
Background: Recent randomized controlled trials (RCTs) support using physiotherapeutic scoliosis-specific exercises (PSSE) for adolescents with idiopathic scoliosis (AIS). All RCTs reported statistically significant results favouring PSSE but none reported on clinical significance. The number needed to treat (NNT) helps determine if RCT results are clinically meaningful. The NNT is the number of patients that need to be treated to prevent one bad outcome in a given period. A low NNT suggests that a therapy has positive outcomes in most patients offered the therapy...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/29161776/awareness-on-cytology-procedure-in-oral-cancer-detection-among-undergraduates-an-institutional-study
#19
Gayathri Ramesh, Rajeev Pathak, Sunita Pathak, Amrita Raj, Amit Kumar, Anuradha Katiyar
Background: The screening and the early detection of the premalignant and malignant lesions are the only means for controlling the oral cancer which is known to be one of the leading causes for mortality worldwide. Oral exfoliative cytology though not a substitute for biopsy can be a powerful tool for its early detection. Dental Surgeons can play a great role in this direction. Aims and Objectives: The present study was undertaken to assess the self-reported knowledge and attitude regarding the early detection of oral cancer and exfoliative cytology among the undergraduates of Rama Dental College, Kanpur...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29160904/three-dimensional-accuracy-of-digital-static-interocclusal-registration-by-three-intraoral-scanner-systems
#20
Kuan Yee Wong, Roxanna Jean Esguerra, Vanessa Ai Ping Chia, Ying Han Tan, Keson Beng Choon Tan
PURPOSE: Prior studies have defined the accuracy of intraoral scanner (IOS) systems but the accuracy of the digital static interocclusal registration function of these systems has not been reported. This study compared the three-dimensional (3D) accuracy of the digital static interocclusal registration of 3 IOS systems using the buccal bite scan function. MATERIALS AND METHODS: Three IOS systems compared were 3MTM True Definition Scanner (TDS), TRIOS Color (TRC), and CEREC AC with CEREC Omnicam (CER)...
November 21, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
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