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https://www.readbyqxmd.com/read/29718144/genomic-surveillance-reveals-diversity-of-multidrug-resistant-organism-colonization-and-infection-a-prospective-cohort-study-in-liver-transplant-recipients
#1
Nenad Macesic, Angela Gomez-Simmonds, Sean B Sullivan, Marla J Giddins, Samantha A Ferguson, Gautam Korakavi, David Leeds, Sarah Park, Kevin Shim, Madeleine G Sowash, Melanie Hofbauer, Ryan Finkel, Yue Hu, Jared West, Nora C Toussaint, William G Greendyke, Benjamin A Miko, Marcus R Pereira, Susan Whittier, Elizabeth C Verna, Anne-Catrin Uhlemann
Background: Multidrug-resistant organisms (MDROs) are an important cause of morbidity and mortality after solid organ transplantation. We aimed to characterize MDRO colonization dynamics and infection in liver transplant (LT) recipients through innovative use of active surveillance and whole-genome sequencing (WGS). Methods: We prospectively enrolled consecutive adult patients undergoing LT from March 2014 to March 2016. Fecal samples were collected at multiple timepoints from time of enrollment to 12 months posttransplant...
April 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29658220/-multiresistant-bacteria-practical-aspects-for-doctors-working-in-ambulatory-practice
#2
Sarah Masson-Roy, Stephan Harbarth
Although preventive measures against the transmission of multidrug-resistant organisms (MDROs) are well established and protocolized in hospital settings, their implementation in private ambulatory practice are rarely addressed. Despite what is sometimes communicated, the risk of transmission of this type of bacteria outside of a hospital environment is real. Standard precautions are the key to minimizing this risk. In a number of situations in the ambulatory setting, MDRO screening (nasal or rectal) is needed and recommended...
April 11, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29619291/mrsa-prevalence-among-patient-transport-staff-in-hamburg
#3
Anja Schablon, Olaf Kleinmüller, Albert Nienhaus, Claudia Peters
Introduction: Patient transport employees frequently come into contact with multidrug-resistant organisms (MDROs) and therefore are at a greater risk of infection than the general population. These pathogens pose a significant challenge for employees of patient transport services since they can spread over long distances through patient transfers. To date, little is known about the occupational risk of MRSA infection in patient transport settings. Methods: A cross-sectional study was conducted to investigate the prevalence of MRSA in patient transport personnel, including taxi drivers, as well as the potential risk factors for MRSA colonization...
2018: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/29588324/wisconsin-microbiome-study-a-cross-sectional-investigation-of-dietary-fibre-microbiome-composition-and-antibiotic-resistant-organisms-rationale-and-methods
#4
Shoshannah Eggers, Kristen Mc Malecki, Paul Peppard, Julie Mares, Daniel Shirley, Sanjay K Shukla, Keith Poulsen, Ronald Gangnon, Megan Duster, Ashley Kates, Garret Suen, Ajay K Sethi, Nasia Safdar
INTRODUCTION: Prevention of multidrug-resistant organism (MDRO) infections, such as those caused by methicillin-resistant Staphylococcus aureus , vancomycin-resistant enterococci, fluoroquinolone-resistant Gram-negative bacteria and Clostridium difficile is crucial. Evidence suggests that dietary fibre increases gut microbial diversity, which may help prevent colonisation and subsequent infection by MDROs. The aim of the Winning the War on Antibiotic Resistance (WARRIOR) project is to examine associations of dietary fibre consumption with the composition of the gut microbiota and gut colonisation by MDROs...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29580299/a-systematic-review-of-the-burden-of-multidrug-resistant-healthcare-associated-infections-among-intensive-care-unit-patients-in-southeast-asia-the-rise-of-multidrug-resistant-acinetobacter-baumannii
#5
Nattawat Teerawattanapong, Pornpansa Panich, Disorn Kulpokin, Siriwat Na Ranong, Khachen Kongpakwattana, Atibodi Saksinanon, Bey-Hing Goh, Learn-Han Lee, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
OBJECTIVETo summarize the clinical burden (cumulative incidence, prevalence, case fatality rate and length of stay) and economic burden (healthcare cost) of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDROs) among patients in intensive care units (ICUs) in Southeast Asia.DESIGNSystematic review.METHODSWe conducted a comprehensive literature search in PubMed, EMBASE, CINAHL, EconLit, and the Cochrane Library databases from their inception through September 30, 2016. Clinical and economic burdens and study quality were assessed for each included study...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29577058/infectious-diseases-consultation-reduces-30-day-and-1-year-all-cause-mortality-for-multidrug-resistant-organism-infections
#6
Jason P Burnham, Margaret A Olsen, Dustin Stwalley, Jennie H Kwon, Hilary M Babcock, Marin H Kollef
Background: Multidrug-resistant organism (MDRO) infections are associated with high mortality and readmission rates. Infectious diseases (ID) consultation improves clinical outcomes for drug-resistant Staphylococcus aureus bloodstream infections. Our goal was to determine the association between ID consultation and mortality following various MDRO infections. Methods: This study was conducted with a retrospective cohort (January 1, 2006-October 1, 2015) at an academic tertiary referral center...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29562944/long-term-impact-of-universal-contact-precautions-on-rates-of-multidrug-resistant-organisms-in-icus-a-comparative-effectiveness-study
#7
E Yoko Furuya, Bevin Cohen, Haomiao Jia, Elaine L Larson
OBJECTIVETo evaluate the impact of universal contact precautions (UCP) on rates of multidrug-resistant organisms (MDROs) in intensive care units (ICUs) over 9 yearsDESIGNRetrospective, nonrandomized observational studySETTINGAn 800-bed adult academic medical center in New York CityPARTICIPANTSAll patients admitted to 6 ICUs, 3 of which instituted UCP in 2007METHODSUsing a comparative effectiveness approach, we studied the longitudinal impact of UCP on MDRO incidence density rates, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and carbapenem-resistant Klebsiella pneumoniae...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29533544/severe-infections-caused-by-multidrug-resistant-non-fermentative-bacilli-in-southern-poland
#8
Agnieszka Chmielarczyk, Monika Pobiega, Grzegorz Ziółkowski, Monika Pomorska-Wesołowska, Dorota Romaniszyn, Lech Krawczyk, Jadwiga Wójkowska-Mach
BACKGROUND: The impact of multidrug-resistant organisms (MDROs), including non-fermentative bacilli (NFBs), is rising and underestimated, especially in intensive care units (ICUs). The growing prevalence of multidrug resistance (MDR) and extensive drug resistance (XDR) is challenging for clinicians, as the treatment options are limited. OBJECTIVES: The purpose of this study was to analyze the extent of the epidemiological problem of multidrugresistant, extensively drug-resistant and pandrug-resistant (PDR) non-fermentative bacilli isolated from pneumonia and bloodstream infections (BSIs) in patients hospitalized in southern Poland...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29530709/predominance-of-methicillin-resistant-staphylococcus-aureus-in-the-residents-and-environments-of-long-term-care-facilities-in-taiwan
#9
Chia-Ying Liu, Chih-Cheng Lai, Hsiu-Tzy Chiang, Min-Chi Lu, Ling-Fang Wang, Tsai-Ling Tsai, Mei-Yu Kang, Yi-Ni Jan, Yi-Ting Lo, Wen-Chien Ko, Shu-Hui Tseng, Chun-Ming Lee, Po-Ren Hsueh
BACKGROUND/PURPOSE: This study investigated the distribution and persistence of multidrug resistant organisms (MDROs) including methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and multidrug-resistant Acinetobacter baumannii (MDRAB) in six long-term care facilities (LTCFs). METHODS: We investigated the distribution of MDROs in residents of six LTCFs and their environments from January to December 2016 (intervention period)...
February 21, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29485019/role-of-hand-hygiene-ambassador-and-implementation-of-directly-observed-hand-hygiene-among-residents-in-residential-care-homes-for-the-elderly-in-hong-kong
#10
Vincent C C Cheng, Hong Chen, Shuk-Ching Wong, Jonathan H K Chen, Wing-Chun Ng, Simon Y C So, Tuen-Ching Chan, Sally C Y Wong, Pak-Leung Ho, Lona Mody, Felix H W Chan, Andrew T Y Wong, Kwok-Yung Yuen
OBJECTIVEMultidrug-resistant organisms (MDROs) are increasingly reported in residential care homes for the elderly (RCHEs). We assessed whether implementation of directly observed hand hygiene (DOHH) by hand hygiene ambassadors can reduce environmental contamination with MDROs.METHODSFrom July to August 2017, a cluster-randomized controlled study was conducted at 10 RCHEs (5 intervention versus 5 nonintervention controls), where DOHH was performed at two-hourly intervals during daytime, before meals and medication rounds by a one trained nurse in each intervention RCHE...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29467368/culture-free-bacterial-detection-and-identification-from-blood-with-rapid-phenotypic-antibiotic-susceptibility-testing
#11
Xuyang Shi, Usha Kadiyala, J Scott VanEpps, Siu-Tung Yau
The current culture-based approach for the diagnosis of bloodstreams infection is incommensurate with timely treatment and curbing the prevalence of multi-drug resistant organisms (MDROs) due to its long time-to-result. Bloodstream infections typically involve extremely low (e.g., <10 colony-forming unit (CFU)/mL) bacterial concentrations that require a labor-intensive process and as much as 72 hours to yield a diagnosis. Here, we demonstrate a culture-free approach to achieve rapid diagnosis of bloodstream infections...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29417921/setting-a-research-agenda-in-prevention-of-healthcare-associated-infections-hais-and-multidrug-resistant-organisms-mdros-outside-of-acute-care-settings
#12
Charlesnika T Evans, Robin L Jump, Sarah L Krein, Suzanne F Bradley, Christopher J Crnich, Kalpana Gupta, Eli N Perencevich, Mark W Vander Weg, Daniel J Morgan
No abstract text is available yet for this article.
February 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29416463/effect-of-extended-infusion-of-meropenem-and-nebulized-amikacin-on-gram-negative-multidrug-resistant-ventilator-associated-pneumonia
#13
Mona Ahmed Ammar, Waleed Abdalla
Background: Ventilator-associated pneumonia (VAP) due to multidrug-resistant organisms (MDROs) is associated with a significant mortality in the Intensive Care Unit (ICU). The aim of this study was to compare the efficacy and safety of extended infusion of meropenem and nebulized amikacin on VAP caused by Gram-negative MDRO versus intravenous (IV) meropenem and amikacin alone. Methodology: A randomized nonblinded controlled trial was performed on ninety patients with VAP...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29298133/epidemiology-and-risk-factors-for-isolation-of-multi-drug-resistant-organisms-in-patients-with-complicated-intra-abdominal-infections
#14
Francesco M Labricciosa, Massimo Sartelli, Lilian M Abbo, Pamela Barbadoro, Luca Ansaloni, Federico Coccolini, Fausto Catena
BACKGROUND: Patients with complicated intra-abdominal infections (cIAIs) caused by multi-drug-resistant organisms (MDROs) have been identified as being at increased risk for adverse outcomes. Prompt identification and stratification of these patients is essential in the clinical management, allowing the physician timely optimization of empiric antimicrobial therapy while awaiting results of intra-operative cultures to streamline antibiotic treatment. METHODS: The study is a secondary analysis from two prospective multi-center color surveillance studies...
April 2018: Surgical Infections
https://www.readbyqxmd.com/read/29277528/determinants-of-inappropriate-empirical-antibiotic-treatment-systematic-review-and-meta-analysis
#15
REVIEW
Elena Carrara, Iris Pfeffer, Oren Zusman, Leonard Leibovici, Mical Paul
This systematic review assessed study-level determinants of non-covering (inappropriate) empirical antibiotic treatment (IEAT), focusing on the influence of study years and the prevalence of multidrug-resistant organisms (MDROs) in the study. Prospective and retrospective observational studies reporting on the association between IEAT and mortality in adult patients with microbiologically documented infections published between 2008-2016 were included. A meta-analysis of IEAT rates was conducted using a random-effects model...
April 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29262416/consensus-on-wound-antisepsis-update-2018
#16
Axel Kramer, Joachim Dissemond, Simon Kim, Christian Willy, Dieter Mayer, Roald Papke, Felix Tuchmann, Ojan Assadian
Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29248023/readmissions-with-multidrug-resistant-infection-in-patients-with-prior-multidrug-resistant-infection
#17
Jason P Burnham, Jennie H Kwon, Margaret A Olsen, Hilary M Babcock, Marin H Kollef
OBJECTIVE To determine incidence of and risk factors for readmissions with multidrug-resistant organism (MDRO) infections among patients with previous MDRO infection. DESIGN Retrospective cohort of patients admitted between January 1, 2006, and October 1, 2015. SETTING Barnes-Jewish Hospital, a 1,250-bed academic tertiary referral center in St Louis, Missouri. METHODS We identified patients with MDROs obtained from the bloodstream, bronchoalveolar lavage (BAL)/bronchial wash, or other sterile sites. Centers for Disease Control and prevention (CDC) and European CDC definitions of MDROs were utilized...
January 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29176351/bacteremia-in-patients-with-liver-cirrhosis-prevalence-and-predictors-of-multidrug-resistant-organisms
#18
Jennifer N Addo Smith, Raymond Yau, Hannah P Russo, Kimberly Putney, Alejandro Restrepo, Kevin W Garey, Amelia K Sofjan
GOALS: The objective of this study was to assess the prevalence and predictors of multidrug resistant organisms (MDRO) in cirrhotic patients with bacteremia at a large tertiary center in the United States. BACKGROUND: The epidemiology of bacteremia in patients with liver cirrhosis has not been well studied in the United States. STUDY: This case-case control study included 180 adults with liver cirrhosis hospitalized from 2011 to 2015. Case group 1 were patients with bacteremia due to a MDRO (n=30)...
November 23, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29150378/enhanced-antibacterial-effects-of-green-synthesized-zno-nps-using-aristolochia-indica-against-multi-drug-resistant-bacterial-pathogens-from-diabetic-foot-ulcer
#19
Katherin Steffy, G Shanthi, Anson S Maroky, S Selvakumar
BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value...
November 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29144223/no-touch-disinfection-methods-to-decrease-multidrug-resistant-organism-infections-a-systematic-review-and-meta-analysis
#20
Alexandre R Marra, Marin L Schweizer, Michael B Edmond
BACKGROUND Recent studies have shown that using no-touch disinfection technologies (ie, ultraviolet light [UVL] or hydrogen peroxide vapor [HPV] systems) can limit the transmission of nosocomial pathogens and prevent healthcare-associated infections (HAIs). To investigate these findings further, we performed a systematic literature review and meta-analysis on the impact of no-touch disinfection methods to decrease HAIs. METHODS We searched PubMed, CINAHL, CDSR, DARE and EMBASE through April 2017 for studies evaluating no-touch disinfection technology and the nosocomial infection rates for Clostridium difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and other multidrug-resistant organisms (MDROs)...
November 16, 2017: Infection Control and Hospital Epidemiology
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