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Detrusor muscle

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https://www.readbyqxmd.com/read/29306925/calcium-sensitization-mechanisms-in-detrusor-smooth-muscles
#1
REVIEW
Irfan Anjum
The contraction of detrusor smooth muscles depends on the increase in intracellular calcium. The influx of calcium from the plasma membrane calcium channels and calcium release from the sarcoplasmic reticulum give rise to intracellular calcium. Under the pathophysiological conditions, the increased sensitivity of regulatory and contractile proteins to calcium also plays an important role in maintaining the spontaneous detrusor smooth muscle activity. Many proteins have been identified to play a role in calcium sensitization...
January 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29306638/rectus-abdominis-detrusor-myoplasty-radm-for-acontractile-hypocontractile-bladder-in-spinal-cord-injury-patients-preliminary-report
#2
Pawan Agarwal, Shabbir Husain, Sudesh Wankhede, D Sharma
BACKGROUND: Urinary bladder dysfunction in the form of acontractile/hypocontractile bladder is very common after spinal cord injury and it may lead to recurrent urinary tract infection (UTI), stones formation, and deteriorating renal function. Conventionally, these patients evacuate their bladders by life-long clean intermittent catheterization (CIC) or an indwelling catheter (IC). For these patients, another option is to use innervated skeletal muscle wrap around the bladder to augment detrusor function and voluntary evacuation of bladder...
December 14, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#3
Jonathan J Crook, Charly Brouillard, Pedro Irazoqui, Thelma Lovick
Objective Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29284441/expression-of-cannabinoid-1-and-2-receptors-and-the-effects-of-cannabinoid-1-and-2-receptor-agonists-on-detrusor-overactivity-associated-with-bladder-outlet-obstruction-in-rats
#4
Sung Dae Kim, Kang Jun Cho, Joon Chul Kim
BACKGROUND: This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats. METHODS: Male Sprague Dawley rats were randomly assigned to four groups (n = 10) in each group. The control group comprised sham-operated rats. A animals in the BOO, CB1 agonist and CB2 agonist groups all underwent BOO surgery. Three weeks postoperatively, cystometrography (CMG) was performed on all rats...
December 29, 2017: BMC Urology
https://www.readbyqxmd.com/read/29279882/new-therapeutic-directions-to-treat-underactive-bladder
#5
REVIEW
Toby C Chai, Tambudzai Kudze
Underactive bladder (UAB) is a term used to describe a constellation of symptoms that is perceived by patients suggesting bladder hypocontractility. Urodynamic measurement that suggest decreased contractility of the bladder is termed detrusor underactivity (DUA). Regulatory approved specific management options with clinically proven ability to increase bladder contractility do not currently exist. While DUA specific treatments presumably will focus on methods to increase efficiency of bladder emptying capability relying on augmenting the motor pathway in the micturition reflex, other approaches include methods to augment the sensory (afferent) contribution to the micturition reflex which could result in increased detrusor contractility...
December 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29241311/a-larger-detrusor-wall-thickness-increases-the-risk-of-non-muscle-invasive-bladder-cancer-recurrence-and-progression-result-from-a-multicenter-observational-study
#6
Antonio Cicione, Stefano Manno, Giuseppe Ucciero, Francesco Cantiello, Rocco Damiano, Estevao Lima, Alessandro Posti, Filippo Balloni, Cosimo DE Nunzio
BACKGROUND: Recent experimental study showed a higher incidence of bladder cancer in presence of bladder detrusor muscle thickening. The aim of this study is to assess whether a higher detrusor muscle thickness (DWT) may be a risk factor of recurrence of non-muscle invasive urothelial bladder cancer (NMIBC). METHODS: Men with histologically-confirmed diagnosis of NMIBC were prospectively enrolled in 4 centers between December 2015 and April 2017. DWT was measured by ultrasound and DWT>2...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29237956/utility-of-the-laminin-immunohistochemical-stain-in-distinguishing-invasive-from-noninvasive-urothelial-carcinoma
#7
Dinesh Pradhan, Milon Amin, Shveta Hooda, Rajiv Dhir, Sheldon Bastacky, Anil V Parwani
BACKGROUND: To study the utility of the laminin immunostain in distinguishing invasive from noninvasive urothelial carcinoma (UC). The distinction is difficult but clinically significant as it can affect the decision to administer intravesical Bacillus Calmette-Guerin or can even lead to cystectomy. MATERIALS AND METHODS: Representative sections of the transurethral resection of bladder tumor specimens from 25 cases of formalin-fixed paraffin-embedded invasive UCs and 25 cases of noninvasive UCs were selected for immunohistochemical (IHC) staining with laminin (Ventana, Oro Valley, AZ, USA)...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29234540/bipolar-plasma-kinetic-enucleation-of-non-muscle-invasive-bladder-cancer-initial-experience-with-a-novel-technique
#8
Ahmed A Abotaleb, Wael S Kandeel, Basheer Elmohamady, Yasser A Noureldin, Waleed El-Shaer, Ahmed Sebaey
Objective: To assess the effectiveness and safety of bipolar plasma kinetic energy for en bloc enucleation of non-muscle-invasive bladder cancer (NMIBC). Patients and methods: In all, 46 patients diagnosed with suspected NMIBC were included. All patients were diagnosed using ultrasonography, computed tomography, and diagnostic cystoscopy, and then underwent bipolar plasma kinetic enucleation of bladder tumour (PKEBT). At the end of the procedure, all patients had a single-dose (40 mg in 40 mL saline) intravesical installation of mitomycin C (<6 h after bipolar PKEBT)...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29221474/increased-expression-of-neuregulin-1-in-the-urothelium-of-rat-bladder-with-partial-bladder-outlet-obstruction
#9
Seung Woo Yang, Seong Woo Jeong, Ki Hak Song
BACKGROUND: This study determined whether changes in the expression of neuregulin (NRG) 1, erbB2 tyrosine kinase (ErbB2) and the M2 muscarinic receptor in the urothelium and detrusor muscle of the rat bladder were associated with partial bladder outlet obstruction (PBOO). METHODS: Male Sprague-Dawley rats (body weight 250-300 g) were used and subdivided into control (n = 10) and PBOO groups (n = 20). PBOO was induced for 21 days, and the expression of NRG1, ErbB2 and M2 muscarinic receptor mRNA and protein was evaluated using reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting, respectively...
December 8, 2017: BMC Urology
https://www.readbyqxmd.com/read/29211339/%C3%AE-3-adrenoceptor-agonists-inhibit-carbachol-evoked-ca2-oscillations-in-murine-detrusor-myocytes
#10
Caoimhin S Griffin, Eamonn Bradley, Mark A Hollywood, Noel G McHale, Keith D Thornbury, Gerard P Sergeant
OBJECTIVE: To test if carbachol-evoked Ca2+ oscillations in freshly isolated murine detrusor myocytes were affected by β3-adrenoceptor modulators. MATERIAL & METHODS: Isometric tension recordings were made from strips of murine detrusor and intracellular Ca2+ measurements were made from isolated detrusor myocytes using confocal microscopy. Transcriptional expression of β-AR sub-types in detrusor strips and isolated detrusor myocytes was assessed using RT-PCR and real-time quantitative PCR...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29201908/effect-of-a-carbohydrate-rich-diet-on-rat-detrusor-smooth-muscle-contractility-an-experimental-study
#11
Mustafa Suat Bolat, Sırrı S Bilge, Ekrem Akdeniz, Onder Cinar, Fatih Firat, Arzu Erdal Agri, Mustafa Bakirtas, Omer Alici, Fikret Erdemir
Objectives: We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats. Materials and Methods: Sprague-Dawley rats were randomized into two groups. The control group received regular food and water. The study group received carbohydrate-rich diet for six weeks. The rats' detrusor muscle was isolated for pharmacological and histopathological examinations. Results: In the control and study groups, mean body weights were 431...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29178500/identifying-unique-subtypes-of-spinal-afferent-nerve-endings-within-the-urinary-bladder-of-mice
#12
Nick J Spencer, Sarah Greenheigh, Melinda Kyloh, Tim J Hibberd, Harman Sharma, Luke Grundy, Stuart M Brierley, Andrea M Harrington, Elizabeth A Beckett, Simon J Brookes, Vladimir P Zagorodnyuk
Spinal afferent neurons are responsible for the transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach conscious sensations from visceral organs to the central nervous system. Although the location of the nerve cell bodies of spinal afferents is well known to reside in dorsal root ganglia (DRG), the morphology and location of peripheral nerve endings of spinal afferents that transduce sensory stimuli into action potentials is poorly understood. The individual nerve endings of spinal afferents that innervate the urinary bladder have never been unequivocally identified in any species...
November 27, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29166277/the-influence-of-doxazosin-on-the-contractility-of-the-urinary-bladder-in-female-pigs-with-experimentally-induced-cystitis
#13
W Markiewicz, A Bossowska, E Lepiarczyk, M Majewski, P Radziszewski, A Wiśniewska, J J Jaroszewski
The present in vitro study investigated the influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis. Fifteen juvenile female piglets (18-20 kg body weight) were randomly assigned into three groups (n=5 animals each): i) control (clinically healthy animals, without doxazosin treatment), ii) animals with induced inflammation of the urinary bladder, but without doxazosin treatment (experimental group I) and iii) animals with inflamed bladder, treated orally with doxazosin (0...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29112292/a-kit-ligand-stem-cell-factor-as-a-possible-mediator-inducing-overactive-bladder
#14
Yasue Kubota, Takashi Hamakawa, Satoshi Osaga, Atsushi Okada, Shuzo Hamamoto, Noriyasu Kawai, Kenjiro Kohri, Takahiro Yasui
OBJECTIVE: To investigate whether c-kit ligand, stem cell factor (SCF) affects the biological behavior of overactive bladder (OAB) and discuss the role of SCF as a possible mediator inducing OAB. MATERIALS AND METHODS: First, we performed an immunohistochemical study to examine the localization of SCF in the guinea pig and human bladder. Next, urinary SCF levels were measured in patients with OAB and in control subjects to evaluate a potential biomarker for the diagnosis of OAB...
November 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29109130/effects-of-electroacupuncture-at-bl33-on-detrusor-smooth-muscle-activity-in-a-rat-model-of-urinary-retention
#15
Xiaoxu Liu, Kun Liu, Mujun Zhi, Qian Mo, Xinyan Gao, Zhishun Liu
BACKGROUND: Detrusor smooth muscle (DSM) underactivity may lead to urinary retention (UR). Electroacupuncture (EA) at BL33 may be effective in improving DSM contractions. OBJECTIVES: This study aimed to investigate: (1) the effect of EA at BL33; and (2) the effect of different manipulation methods at BL33 on the modulation of DSM contractions in UR rats. METHODS: 30 male Sprague-Dawley rats were anaesthetised with urethane and modelled by urethral outlet obstruction...
November 6, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29100756/trpv1-alterations-in-urinary-bladder-dysfunction-in-a-rat-model-of-stz-induced-diabetes
#16
Bizhan R Sharopov, Kseniya L Gulak, Igor B Philyppov, Anna V Sotkis, Yaroslav M Shuba
AIMS: More than half of diabetic patients experience voiding disorder termed diabetic urinary bladder dysfunction (DBD). Here we have investigated how the alterations in transient receptor potential vanilloid 1 (TRPV1) ion channel expressed in bladder-innervating afferents may contribute to DBD pathogenesis. MAIN METHODS: The rat model of streptozotocin (STZ)-induced diabetes was used. The functional profile of TRPV1 in retrogradely labeled afferent, bladder-innervating dorsal root ganglia (DRG) neurons was examined using patch clamp...
October 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/29092859/urinary-bladder-hypertrophy-is-susceptible-in-male-but-protected-in-female-romk-bartter-s-mouse
#17
Jun-Mo Kim, Shuhua Xu, Xiaoyun Guo, Haiyan Hu, Ke Dong, Tong Wang
The renal outer medullary potassium channel (ROMK; Kir1.1) plays an important role in Na(+) and K(+) homeostasis. ROMK knockout mice (KO) show a similar phenotype to Bartter's syndrome of salt wasting and dehydration due to reduced Na-2Cl-K-cotransporter activity but not in ROMK1 KO. ROMK KO mice also show hydronephrosis; however, the mechanism of this phenotype has not been understood. We have previously demonstrated a gender-sex difference in hydronephrosis and PGE2 production in ROMK KO mouse. In this study we compared the gender-sex difference in bladder hypertrophy and hydronephrosis in ROMK KO mice...
November 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29060454/a-computational-model-of-intracellular-calcium-oscillations-in-urinary-bladder-smooth-muscle-cells
#18
Suranjana Gupta, Avni Majawadia, Rohit Manchanda
This paper presents a computational model for calcium (Ca(2+)) oscillations in detrusor smooth muscle (DSM) cells. The proposed model simulates the temporal profile of oscillations by incorporating various cellular and subcellular components. The cellular components include calcium influx via membrane and the plasma membrane calcium ATPase (PMCA) pump. The subcellular components include ryanodine receptors (RyRs), inositol 1, 4, 5 trisphosphate receptors (IP3Rs) and the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29039043/layer-dependent-role-of-collagen-recruitment-during-loading-of-the-rat-bladder-wall
#19
Fangzhou Cheng, Lori A Birder, F Aura Kullmann, Jack Hornsby, Paul N Watton, Simon Watkins, Mark Thompson, Anne M Robertson
In this work, we re-evaluated long-standing conjectures as to the source of the exceptionally large compliance of the bladder wall. Whereas these conjectures were based on indirect measures of loading mechanisms, in this work we take advantage of advances in bioimaging to directly assess collagen fibers and wall architecture during biaxial loading. A custom biaxial mechanical testing system compatible with multiphoton microscopy was used to directly measure the layer-dependent collagen fiber recruitment in bladder tissue from 9 male Fischer rats (4 adult and 5 aged)...
October 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29031900/resveratrol-improved-detrusor-fibrosis-induced-by-mast-cells-during-progression-of-chronic-prostatitis-in-rats
#20
Yi He, Huizhi Zeng, Yang Yu, Jiashu Zhang, Qi Liu, Bo Yang
To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. Experiments of bladder pressure and volume test in rats are used to investigate the effect of resveratrol on urinary dysfunction in CP rats. To assess tissue fibrosis, picrosirius red staining is performed...
October 12, 2017: European Journal of Pharmacology
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