keyword
MENU ▼
Read by QxMD icon Read
search

Detrusor muscle

keyword
https://www.readbyqxmd.com/read/28627603/role-of-stem-cell-factor-in-the-regulation-of-icc-proliferation-and-detrusor-contraction-in-rats-with-an-underactive-bladder
#1
Jianli Feng, Jin Gao, Shan Zhou, Yuanfeng Liu, Yu Zhong, Yong Shu, Ming Sen Meng, Jiaqiang Yan, Danning Sun, Qiang Fang, Daodong Sun
Stem cell factor (SCF) is critical in regulating the proliferation, differentiation and function of the interstitial cells of Cajal (ICCs), which are closely associated with smooth muscle dysfunction. The present study aimed to examine the effect of SCF on ICC proliferation and detrusor contraction in rats with an underactive bladder. Sprague‑Dawley rats were divided into four groups comprising control, control+SCF, detrusor underactivity (DU), and DU+SCF groups. The ICC count was determined using immunofluorescence; serum levels of SCF were determined using an enzyme‑linked immunosorbent assay; mRNA and protein levels of c‑kit and SCF in tissues were assessed using reverse transcription‑quantitative polymerase chain reaction and western blot analyses, respectively...
June 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28596838/botulinum-neurotoxins-serotypes-a-and-b-induce-paralysis-of-mouse-striated-and-smooth-muscles-with-different-potencies
#2
Jacquie Maignel-Ludop, Marion Huchet, Johannes Krupp
To address the scarcity of direct comparison of botulinum neurotoxin serotypes activity on smooth versus striatal muscle, we have studied the action of BoNT/A1 and BoNT/B1 on ex vivo preparations of both muscle types. We have set up and characterized a model of neurogenic contractions in the isolated mouse bladder, and used this model to explore the effects of the two serotypes on contractions evoked by electrical field stimulation. Both toxins were also tested in the mouse phrenic nerve hemidiaphragm assay, to compare their potency in smooth versus striated muscle...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28593170/increased-detrusor-collagen-is-associated-with-detrusor-overactivity-and-decreased-bladder-compliance-in-men-with-benign-prostatic-obstruction
#3
Carlos H S Bellucci, Wesley de O Ribeiro, Thiago S Hemerly, José de Bessa, Alberto A Antunes, Katia R M Leite, Homero Bruschini, Miguel Srougi, Cristiano M Gomes
BACKGROUND: This study aimed to investigate the relationship between detrusor collagen content and urodynamic parameters in men with benign prostatic obstruction. MATERIAL AND METHODS: Nineteen consecutive patients undergoing open prostatectomy for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) were evaluated. Urodynamic tests were performed in all patients. BOO and detrusor contractility were assessed with the BOO index (BOOI) and the bladder contractility index (BCI), respectively...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28587917/home-urodynamic-pressures-and-volume-measurement-for-the-neurogenic-bladder-initial-validation-study
#4
Guy Hidas, Tandis Soltani, John Billimek, Blake Selby, Maryellen S Kelly, Gordon McLorie, Elias Wehbi, Antoine E Khoury
AIMS: To evaluate the ability of a bladder pressure/volume diary (PVD) to identify patients at risk for elevated intravesical pressures. METHODS: Clean intermittent catheterization (CIC) dependent patients used ruler-based manometry to measure intravesical pressures prior to leakage or scheduled drainage at home. We prospectively collected clinical, urodynamic (UDS), and PVD data in patients with spina bifida who were optimized on anticholinergic therapy and on CIC...
June 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28587421/effect-of-suo-quan-wan-on-the-bladder-function-of-aging-rats-based-on-the-%C3%AE-adrenoceptor
#5
Yi-Fei Xu, Zhi-Jian Liang, Zhao-Jin Kuang, Jie-Jun Chen, Jun Wu, Xiang-E Lu, Wei-Wen Jiang, Ping-Long Fan, Li-Yao Tang, Yi-Tao Li, Ping Huang, Hong-Ying Cao
Suo Quan Wan (SQW) has been used to treat lower urinary tract symptoms (LUTS) in elderly patients for hundreds of years in China. β-adrenoceptors (β-ARs), particularly β3-adrenoceptor (β3-AR), was reported to be important in the bladder dysfunction of the elderly. The present study was conducted to explore the effect of β-AR, and particularly the β3-adrenoceptor, in aging rat bladder function in vitro and to test the therapeutic effect of SQW on LUTS in an aging rat model based on the β3-adrenoceptor...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28546038/-pathophysiology-of-detrusor-underactivity-in-the-elderly
#6
J Kerdraon, B Peyronnet, X Gamé, B Fatton, R Haddad, C Hentzen, C Jeandel, P Mares, M Mezzadri, A-C Petit, G Robain, J-M Vetel, G Amarenco
AIM: The aim of this study was to review the evidence regarding the pathophysiology of detrusor underactivity in the elderly. METHODS: A literature review was conducted in July 2016 using the Medline/Pubmed database limiting the search to works in English or French. RESULTS: The prevalence of detrusor underactivity has been reported to range from 8% to 48% depending on the definition used and the age of the population studied. Current data suggest that aging may itself be a causative factor of detrusor underactivity through myogenic dysfunctions (ultrastructural degeneration of the detrusor muscle) and neurogenic dysfunctions (by degeneration of efferent but mostly afferent innervation mechanisms)...
May 22, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28539337/altered-expression-and-modulation-of-the-two-pore-domain-k2p-mechano-gated-potassium-channel-trek-1-in-overactive-human-detrusor
#7
Ricardo H Pineda, Balachandar Nedumaran, Joseph A Hypolite, Xiao-Qing Pan, Shandra Wilson, Randall B Meacham, Anna P Malykhina
Background Detrusor overactivity (DO) is the abnormal response of the urinary bladder to physiological stretch during the filling phase of the micturition cycle. The mechanisms of bladder smooth muscle compliance upon the wall stretch are poorly understood. We previously reported that the function of normal detrusor is regulated by TREK-1, a member of the mechano-gated subfamily of two-pore domain potassium (K2P) channels. In the present study, we aimed to identify the changes in expression and function of TREK-1 channels under pathological conditions associated with DO, evaluate the potential relationship between TREK-1 channels and cytoskeletal proteins in the human bladder, and test the possibility of modulation of TREK-1 channel expression by small RNAs...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#8
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28537696/electron-microscopic-changes-of-detrusor-in-benign-enlargement-of-prostate-and-its-clinical-correlation
#9
Sher Singh Yadav, Rohit Bhattar, Lokesh Sharma, Gautam Banga, Trilok Chandra Sadasukhi
AIMS: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. MATERIAL AND METHODS: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28511871/effect-of-distigmine-on-the-contractile-response-of-guinea-pig-urinary-bladder-to-electrical-field-stimulation
#10
Keisuke Obara, Yurina Kobayashi, Daisuke Chino, Yoshio Tanaka
Distigmine bromide (distigmine) is a reversible carbamate group cholinesterase (ChE) inhibitor. Although mainly used clinically for the treatment of myasthenia gravis, distigmine is also indicated for detrusor underactivity in Japan. According to the pharmacological classification of distigmine, its therapeutic effect against detrusor underactivity appears to be produced by enhanced urinary bladder smooth muscle (UBSM) contractility due to an increased concentration of acetylcholine between parasympathetic nerve endings and UBSM cells...
May 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28506097/a-computational-model-of-the-ca-2-transients-and-influence-of-buffering-in-guinea-pig-urinary-bladder-smooth-muscle-cells
#11
Vijay Dave, Rohit Manchanda
Many cellular events including electrical activity and muscle contraction are regulated and coordinated by intracellular [Formula: see text] concentration ([[Formula: see text]][Formula: see text]. In detrusor smooth muscle (DSM) cells, [[Formula: see text]]i is normally maintained at very low levels and rises transiently during signalling processes as a result of (i) influx from the extracellular space (mainly via L-type and T-type [Formula: see text] channels) and (ii) [Formula: see text] release from sarcoplasmic reticulum (SR) into the cytoplasm...
April 20, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28490527/reversible-plasticity-of-detrusor-smooth-muscle-evidence-for-a-key-role-of-slipping-actomyosin-crossbridges-in-the-control-of-urinary-bladder-compliance
#12
https://www.readbyqxmd.com/read/28437806/potential-of-bryophyllum-pinnatum-as-a-detrusor-relaxant-an-in-vitro-exploratory-study
#13
Simon Bachmann, Cornelia Betschart, Julia Gerber, Karin Fürer, Mónica Mennet, Matthias Hamburger, Olivier Potterat, Ursula von Mandach, Ana Paula Simões-Wüst
An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl...
April 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28419532/electromyography-in-the-assessment-and-therapy-of-lower-urinary-tract-dysfunction-in-adults
#14
REVIEW
Jan Krhut, Roman Zachoval, Peter F W M Rosier, Beth Shelly, Peter Zvara
AIM: To present the teaching module "Electromyography in the assessment and therapy of lower urinary tract dysfunction in adults." This teaching module embodies a presentation, in combination with this manuscript. This manuscript serves as a scientific background review; the evidence base made available on ICS website to summarize current knowledge and recommendations. METHODS: This review has been prepared by a Working Group of The ICS Urodynamics Committee. The methodology used included comprehensive literature review, consensus formation by the members of the Working Group, and review by members of the ICS Urodynamics Committee core panel...
April 18, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28417339/expression-and-function-of-the-small-conductance-ca-2-activated-k-channel-is-decreased-in-urinary-bladder-smooth-muscle-cells-from-female-guinea-pig-with-partial-bladder-outlet-obstruction
#15
Ning Li, Honglin Ding, Xiaoning He, Zizheng Li, Yili Liu
PURPOSE: Overactive bladder (OAB), usually accompanied by partial bladder outlet obstruction (PBOO), is associated with detrusor overactivity (DO) which is related to the increased urinary bladder smooth muscle (UBSM) cells excitability. Small-conductance Ca(2+)-activated K(+) (SK) channels play a constitutive regulatory role of UBSM excitability and contractility. PBOO is associated with the decreased SK channels mRNA expression and the attenuated regulative effect of SK channels on UBSM contractility...
July 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28413135/a-systematic-review-of-the-diagnosis-and-treatment-of-patients-with-neurogenic-hyperactivity-of-the-detrusor-muscle
#16
A Borau, J M Adot, M Allué, S Arlandis, D Castro, M Esteban, J Salinas
BACKGROUND: Neurogenic detrusor hyperactivity (NDH) is a urodynamic observation characterised by involuntary detrusor contractions during the filling phase that are caused by an underlying neurological disease. The common and severe complications that can result from NDH warrant the preparation of healthcare protocols for the proper management of patients with NDH. OBJECTIVE: The aim of this study is to standardise the criteria for the decision-making process in the management of patients with diagnosed or suspected NDH, providing personalised medical care...
April 13, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28398951/challenges-in-pathologic-staging-of-bladder-cancer-proposals-for-fresh-approaches-of-assessing-pathologic-stage-in-light-of-recent-studies-and-observations-pertaining-to-bladder-histoanatomic-variances
#17
REVIEW
Gladell P Paner, Rodolfo Montironi, Mahul B Amin
The paradigm of pathologic stage (pT) categorization in bladder cancer remains the depth of invasion into the different histologic layers of the bladder wall. However, the approaches to assigning pT stage category toward an enhanced outcome stratification have been marked by challenges and innovations, due in part to our growing appreciation of the surprisingly perplexing bladder histoanatomy. Upstaging of pT1 tumors after radical cystectomy is substantial and underscores the potential value of pT1 substaging in transurethral resection (TUR) specimens...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28396595/p2y6-deficiency-increases-micturition-frequency-and-attenuates-sustained-contractility-of-the-urinary-bladder-in-mice
#18
Satoru Kira, Mitsuharu Yoshiyama, Sachiko Tsuchiya, Eiji Shigetomi, Tatsuya Miyamoto, Hiroshi Nakagomi, Keisuke Shibata, Tsutomu Mochizuki, Masayuki Takeda, Schuichi Koizumi
The role of the P2Y6 receptor in bladder function has recently attracted a great deal of attention in lower urinary tract research. We conducted this study to determine contributions of the P2Y6 receptor in lower urinary tract function of normal phenotypes by comparing P2Y6-deficient mice and wild-type mice. In in vivo experiments, P2Y6-deficient mice had more frequent micturition with smaller bladder capacity compared to wild-type mice; however, there was no difference between these groups in bladder-filling pressure/volume relationships during cystometry under decerebrate, unanaesthetized conditions...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394495/effect-of-naftopidil-on-bladder-microcirculation-in-a-rat-model-of-bladder-outlet-obstruction
#19
Tsuyoshi Majima, Tokunori Yamamoto, Yasuhito Funahashi, Shun Takai, Yoshihisa Matsukawa, Masaki Yoshida, Momokazu Gotoh
OBJECTIVES: To evaluate the effect of naftopidil on bladder capillary blood flow using bladder outlet obstruction model rats. METHODS: Female Sprague-Dawley rats were divided into three groups: control group, bladder-outlet-obstruction group, and bladder-outlet-obstruction + naftopidil group. Bladder-outlet-obstruction surgery was performed in the bladder-outlet-obstruction and bladder-outlet-obstruction + naftopidil groups. The control group received sham-operation...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28381080/bladder-endometriosis-a-summary-of-current-evidence
#20
Carlo Saccardi, Amerigo Vitagliano, Pietro Litta
Bladder endometriosis is a specific form of endometriosis characterized by the presence of endometrial glands and stroma in the detrusor muscle. Such disease may involve different sites of the bladder, most frequently the base and the dome, with various grade of infiltration. Bladder nodules typically coexists with other localizations of deep pelvic endometriosis, resulting in a wide variety of abdominal and urinary symptoms that may be overlooked by clinicians. In spite of advances in understanding the genetic and molecular development of endometriosis, the clinical approach to bladder lesions is very challenging and may require the use of different diagnostic tools in order to set up a comprehensive diagnostic workup and direct towards the most appropriate treatment...
April 4, 2017: Minerva Ginecologica
keyword
keyword
48180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"