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Detrusor muscle

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https://www.readbyqxmd.com/read/29764932/distribution-of-mast-cell-subtypes-in-interstitial-cystitis-implications-for-novel-diagnostic-and-therapeutic-strategies
#1
Shabana T Malik, Brian R Birch, David Voegeli, Mandy Fader, Vipul Foria, Alan J Cooper, Andrew F Walls, Bashir A Lwaleed
AIMS: To identify the presence and geographical distribution of mast cell (MC) subtypes: MCT (tryptase positive-chymase negative) and MCTC (tryptase positive-chymase positive) in bladder tissue. METHODS: Bladder tissue was obtained from patients with painful bladder syndrome/interstitial cystitis (n=14) and normal histology from University Hospital Southampton tissue bank. Sequential tissue slices were immunohistochemically stained for MC subtypes using anti-MC tryptase (for MCT and MCTC ) and anti-MC chymase (for MCTC )...
May 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29732215/a-ligamentous-explanation-for-overactive-bladder-symptoms-as-defined-by-international-continence-society-in-the-female
#2
REVIEW
Peter Petros
The International Continence Society (ICS) committee has defined overactive bladder (OAB) as "a syndrome characterized by symptoms of urgency, with or without urgency incontinence, usually with increased daytime frequency and nocturia (increased night time urination). The term OAB can only be used if there is no proven infection or other obvious pathology". Though the ICS gives no anatomical basis for OAB, it is suggested that the cause is from the detrusor itself. In this review, urodynamic evidence is presented that OAB in the female may be a prematurely activated but normal micturition reflex, as predicted by the Integral Theory...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29732213/association-between-detrusor-muscle-function-and-level-of-the-spinal-cord-injury
#3
Maryam Kooshesh, Mahdi Safdarian, Abolghasem Nikfallah, Alexander R Vaccaro, Vafa Rahimi-Movaghar
Introduction: Traumatic spinal cord injury (TSCI) is among the most severe disabilities with an estimation of 2.5 million people affected worldwide. The purpose of this study was to investigate the association between detrusor muscle function and the level of the spinal cord injury. Material and methods: All patients with TSCI who underwent urodynamic evaluation at the Brain and Spinal Injury Research Center (BASIR) of Imam Khomeini hospital complex from March 2014 to March 2016 were retrospectively entered in this cross-sectional study...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29704028/contractile-responses-in-intact-and-mucosa-denuded-human-ureter-a-comparison-with-urinary-bladder-detrusor-preparations
#4
Melanie Roedel, Ursula Ravens, Michael Kasper, Manfred P Wirth, Thomas A Jepps, Stefan Propping
Human proximal and distal ureter tissues were studied to clarify whether the presence of mucosa affects contractile responses. In histological studies, human ureter was compared with urinary bladder (detrusor). Contractions in response to high KCl solution, phenylephrine, and carbachol were measured in intact and mucosa-denuded strips of human ureter. Tissue sections of human bladder and ureter were used for histological staining. Thirty-four percent of the ureter strips contracted spontaneously with highly variable patterns, and this was affected neither by mucosa nor by proximal or distal tissue origin...
April 28, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29664135/clinical-outcomes-of-detrusor-underactivity-in-female-with-advanced-pelvic-organ-prolapse-following-vaginal-pelvic-reconstructive-surgery
#5
Tsia-Shu Lo, Sandy Chua, Ma Clarissa Uy-Patrimonio, Chuan C Kao, Chih H Lin
AIM: To determine the impact of vaginal pelvic reconstructive surgery (PRS) on detrusor underactivity (DU) patients having advanced pelvic organ prolapse (POP). METHODS: A retrospective study of patients who underwent PRS for advanced POP (POP-Q ≥ 3) with DU. Data regarding preoperative evaluation, surgical procedure, and post-operative management were collated. Patients were considered to have DU when detrusor pressure at maximum flow (Pdet Qmax ) was ≤10 cmH2 0 and peak flow rate (Qmax ) of ≤12 mL/s...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29643467/potential-orphan-drug-therapy-of-intravesical-liposomal-onabotulinumtoxin-a-for-ketamine-induced-cystitis-by-mucosal-protection-and-anti-inflammation-in-a-rat-model
#6
Wei-Chia Lee, Chia-Hao Su, You-Lin Tain, Cheng-Nan Tsai, Chun-Chieh Yu, Yao-Chi Chuang
Ketamine abusers may develop ulcerative cystitis and severe lower urinary tract symptoms, which is a medical dilemma. Recently, researchers have found the endemic of ketamine-induced cystitis worldwide. The intravesical administration of liposome-encapsulated onabotulinumtoxinA (Lipotoxin) might facilitate the healing of the damaged urothelium from liposomes, and reduce the urinary symptoms by onabotulinumtoxinA-induced chemo-denervation. Using female Sprague-Dawley rats, we investigated the effects of Lipotoxin on ketamine-induced cystitis...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29603776/selective-bladder-denervation-for-overactive-bladder-oab-syndrome-from-concept-to-healing-outcomes-using-the-ovine-model
#7
James Fugett, Lynette Phillips, Emily Tobin, Eric Whitbrook, Haydon Bennett, Joshua Shrout, James E Coad
AIMS: We evaluated a Selective Bladder Denervation (SBD) device, which uses radiofrequency ablation, for the treatment of overactive bladder syndrome in terms of its nerve denervation, ablation characteristics, and post-treatment healing. METHODS: Using the SBD device, eight fresh extirpated ovine bladder trigones were treated (90°C set point for 60 s) and nitroblue tetrazolium viability stained to characterize the ablation. In addition, 12 trigones were treated in vivo with three adjacent ablations and divided into survival cohorts: Day 7, Day 30, and Day 90 to assess the ablations and their associated healing...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29568364/efficacy-of-different-spinal-nerve-roots-for-neuromodulation-of-micturition-reflex-in-rats
#8
Jianshu Ni, Xiaohu Wang, Nailong Cao, Jiemin Si, Baojun Gu
Electrical stimulation of peripheral nerves controlling the bladder is an alternative, nondestructive medical treatment for urinary incontinence and retention. In this study, we aimed to identify the most efficient sensory and motor spinal nerve roots involved in the micturition reflex. Unilateral L5-S2 dorsal and ventral roots were electrically stimulated, and bladder reflex contractions were recorded under isovolumetric conditions. Repeated stimulation of the L6 and S1 dorsal roots not only abolished bladder reflex contractions but also induced a poststimulation inhibitory effect, whereas repeated stimulation of the L5 and S2 dorsal roots had no effect...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29551457/highly-specific-detection-of-muscarinic-m3-receptor-g-protein-interaction-and-intracellular-trafficking-in-human-detrusor-using-proximity-ligation-assay-pla
#9
Mandy Berndt-Paetz, Luise Herbst, Annett Weimann, Andreas Gonsior, Jens-Uwe Stolzenburg, Jochen Neuhaus
PURPOSE: Muscarinic acetylcholine receptors (mAChRs) regulate a number of important physiological functions. Alteration of mAChR expression or function has been associated in the etiology of several pathologies including functional bladder disorders (e.g bladder pain syndrome/interstitial cystitis - BPS/IC). In a previous study we found specific mAChR expression patterns associated with BPS/IC, while correlation between protein and gene expression was lacking. Posttranslational regulatory mechanisms, e...
March 15, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29532875/store-operated-calcium-channels-are-associated-with-diabetic-cystopathy-in-streptozotocin%C3%A2-induced-diabetic-rats
#10
Sen Yang, Dongwen Wang, Xiaoming Cao, Xuhui Zhang, Xiaobin Yuan, Tiancheng Yang, Yang Mi
Store operated calcium channels (SOCCs) have been suggested to play a critical role in many diabetic complications. Diabetic cystopathy (DCP) is common in patients with diabetes, but the role of SOCCs in DCP is still unclear. The aim of the present study was to investigate the role of SOCCs in DCP with streptozocin (STZ)‑induced diabetic rats. Specifically, the authors investigated whether SOCCs were altered in streptozocin (STZ)‑induced diabetic rats and, if so, how this may contribute to the contraction of bladder detrusor strips and the intracellular Ca2+ concentration of bladder smooth muscle cells in diabetic rats...
March 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29523366/repeat-transurethral-resection-in-non-muscle-invasive-bladder-cancer-a-systematic-review
#11
REVIEW
Marcus G K Cumberbatch, Beat Foerster, James W F Catto, Ashish M Kamat, Wassim Kassouf, Ibrahim Jubber, Shahrokh F Shariat, Richard J Sylvester, Paolo Gontero
CONTEXT: Initial treatment for most bladder cancers (BCs) involves transurethral resection (TUR) or tumours. Often more cancer is found after the initial treatment in around half of patients, requiring a second resection. Repeat transurethral resection (reTUR) is recommended for high-risk, non-muscle-invasive bladder cancer (NMIBC) to remove any residual disease and improve cancer outcomes. OBJECTIVE: To systematically review the practice and therapeutic benefit of an early reTUR for high-risk NMIBC...
March 6, 2018: European Urology
https://www.readbyqxmd.com/read/29519236/progressive-bladder-remodeling-due-to-bladder-outlet-obstruction-a-systematic-review-of-morphological-and-molecular-evidences-in-humans
#12
Ferdinando Fusco, Massimiliano Creta, Cosimo De Nunzio, Valerio Iacovelli, Francesco Mangiapia, Vincenzo Li Marzi, Enrico Finazzi Agrò
BACKGROUND: Bladder outlet obstruction is a common urological condition. We aimed to summarize available evidences about bladder outlet obstruction-induced molecular and morphological alterations occurring in human bladder. METHODS: We performed a literature search up to December 2017 including clinical and preclinical basic research studies on humans. The following search terms were combined: angiogenesis, apoptosis, bladder outlet obstruction, collagen, electron microscopy, extracellular matrix, fibrosis, hypoxia, histology, inflammation, innervation, ischemia, pressure, proliferation, remodeling, suburothelium, smooth muscle cells, stretch, urothelium...
March 9, 2018: BMC Urology
https://www.readbyqxmd.com/read/29513744/acute-radiation-impacts-contractility-of-guinea-pig-bladder-strips-affecting-mucosal-detrusor-interactions
#13
Bronagh M McDonnell, Paul J Buchanan, Kevin M Prise, Karen D McCloskey
Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue. This study aimed to investigate the acute impact of ionizing radiation on the contractility of bladder strips and identify the radiation-sensitivity of the mucosa vs the detrusor. Guinea-pig bladder strips (intact or mucosa-free) received ex vivo sham or 20Gy irradiation and were studied with in vitro myography, electrical field stimulation and Ca2+-fluorescence imaging...
2018: PloS One
https://www.readbyqxmd.com/read/29489983/pelvic-floor-muscle-training-for-overactive-bladder-symptoms-a-prospective-study
#14
Fátima Fitz, Marair Sartori, Manoel João Girão, Rodrigo Castro
INTRODUCTION: Pelvic floor muscle training (PFMT) involves the contraction of the puborectal, anal sphincter and external urethral muscles, inhibiting the detrusor contraction, what justify its use in the treatment of overactive bladder (OAB) symptoms. OBJECTIVE: To verify the effects of isolated PFMT on the symptoms of OAB. METHOD: Prospective clinical trial with 27 women with mixed urinary incontinence (MUI), with predominance of OAB symptoms and loss ≥ 2 g in the pad test...
December 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29482891/early-experimental-results-of-using-a-novel-delivery-carrier-hyaluronan-phosphatidylethanolamine-ha-pe-which-may-allow-simple-bladder-instillation-of-botulinum-toxin-a-as-effectively-as-direct-detrusor-muscle-injection
#15
Mohamed Galal El Shatoury, Ling DeYoung, Eva Turley, Arjang Yazdani, Sumit Dave
INTRODUCTION: Botulinum toxin A (BTX-A) is a neurotoxin that inhibits acetylcholine release by cleaving cytosolic synaptosome-associated protein 25 (SNAP-25) and results in bladder relaxation. A BTX-A intravesical injection has been established as an effective option for treating detrusor overactivity. STUDY DESIGN: Sixty female Sprague Dawley rats were equally divided into control and experimental groups. Control Groups 1 to 3 received: BTX-A 10 units + saline instillation; hyaluronan-phosphatidylethanolamine (HA-PE) 0...
December 30, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29478198/transurethral-en-bloc-resection-with-bipolar-button-electrode-for-non-muscle-invasive-bladder-cancer
#16
Junfeng Zhang, Longsheng Wang, Shiyu Mao, Mengnan Liu, Wentao Zhang, Ziwei Zhang, Yadong Guo, Bisheng Huang, Yang Yan, Yong Huang, Xudong Yao
PURPOSE: Transurethral resection of bladder tumor (TURBT) using a wire loop is considered the gold standard for staging and treating non-muscle invasive bladder cancer (NMIBC). TURBT is associated with serious disadvantages that facilitate tumor recurrence. The present study evaluated the safety and efficacy of the bipolar button electrode for en bloc resection of NMIBC. METHODS: From January 2013 to July 2016, 82 consecutive patients newly diagnosed with NMIBC received transurethral en bloc resection with bipolar button electrode...
April 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29464320/comparative-immunohistochemical-characterization-of-interstitial-cells-in-the-urinary-bladder-of-human-guinea-pig-and-pig
#17
Clara Steiner, Thomas Gevaert, Roman Ganzer, Dirk De Ridder, Jochen Neuhaus
Interstitial cells (ICs) are thought to play a functional role in urinary bladder. Animal models are commonly used to elucidate bladder physiology and pathophysiology. However, inter-species comparative studies on ICs are rare. We therefore analyzed ICs and their distribution in the upper lamina propria (ULP), the deeper lamina propria (DLP) and the detrusor muscular layer (DET) of human, guinea pig (GP) and pig. Paraffin slices were examined by immunohistochemistry and 3D confocal immunofluorescence of the mesenchymal intermediate filament vimentin (VIM), alpha-smooth muscle actin (αSMA), platelet-derived growth factor receptor alpha (PDGFRα) and transient receptor potential cation channel A1 (TRPA1)...
February 20, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29427331/the-role-of-the-mucosa-in-modulation-of-evoked-responses-in-the-spinal-cord-injured-rat-bladder
#18
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Fabliha Mahmood, Maryrose P Sullivan, Rosalyn M Adam
AIMS: Mounting evidence indicates that a variety of factors released from the urothelium or suburothelium can modulate smooth muscle activity. Although the relationship between the mucosa and smooth muscle has been investigated, little is known about the pathophysiologic changes in detrusor-mucosa interactions in neurogenic bladders. The goal of the study was to determine the impact of the mucosa on evoked responses in spinal cord injured (SCI) bladders. METHODS: Urinary bladders were obtained from 6wk SCI rats or age-matched uninjured controls...
February 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29423307/the-importance-of-the-bulbocavernosus-reflex
#19
REVIEW
Jean Gabriel Previnaire
The BCR consists of the contraction of the bulbocavernosus muscle in response to squeezing the glans penis or clitoris, and is mediated through the pudendal nerve. In case of a complete lesion, the presence of BCR is indicative of intact S2-S4 spinal reflex arcs and loss of supraspinal inhibition, determining an upper motor neuron (UMN) lesion, its absence a lower motor neuron (LMN) lesion. The BCR further helps distinguish conus medullaris from cauda equina syndromes. Sensory or motor function in the most caudal sacral segments, not BCR, defines the sacral sparing as part of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29406911/anti-cholinergic-medications-for-bladder-dysfunction-worsen-cognition-in-persons-with-multiple-sclerosis
#20
Sarah A Morrow, Heather Rosehart, Alp Sener, Blayne Welk
Bladder dysfunction is common in persons with MS (PwMS), often due to detrusor muscle overactivity. Anticholinergic medications are considered the first line treatment for bladder dysfunction and are known to worsen cognition in healthy older adults and in persons with dementia. Yet, it is not known if these medications have the same effect on PwMS. Thus, the Objective of this prospective matched-cohort study was to determine if anticholinergic medications affect objective measures of cognition in PwMS. We recruited PwMS starting either oxybutynin or tolterodine (cases)...
February 15, 2018: Journal of the Neurological Sciences
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