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https://www.readbyqxmd.com/read/28915706/the-role-of-autophagy-in-hepatocellular-carcinoma-friend-or-foe
#1
REVIEW
Lian Liu, Jia-Zhi Liao, Xing-Xing He, Pei-Yuan Li
Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell's components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Basal autophagy acts as a tumor suppressor by maintaining genomic stability in normal cells...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915290/lifting-the-lower-face-with-an-absorbable-polydioxanone-pdo-thread
#2
Kian Karimi, Alexandra Reivitis
Traditional rejuvenation techniques include chemical peels, rhytidectomy of the skin, laser resurfacing, injection of dermal fillers and neurotoxins, and invasive surgical procedures. Patients with brow ptosis, jowl formation, and deepening nasolabial folds currently seek antiaging procedures with no incisions and minimal downtime such as thread-lifting with barbed sutures. The present report describes a case in which polydioxanone threads were used to lift the lower third of a patient's face. Fillers were used to supplement the results achieved by the thread lift because often, when tissue has been lifted, volume deficits are revealed, which can be corrected with dermal fillers...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28910861/antioxidative-and-antiaging-activities-and-component-analysis-of-lespedeza-cuneata-g-don-extracts-fermented-with-lactobacillus-pentosus
#3
Joon Seob Seong, Song Hua Xuan, So Hyun Park, Keon Soo Lee, Young Min Park, Soo Nam Park
Lespedeza cuneata G. Don is a traditional herb that has been shown to associate with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells...
September 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28900534/resveratrol-enriched-rice-attenuates-uvb-ros-induced-skin-aging-via-downregulation-of-inflammatory-cascades
#4
Lalita Subedi, Taek Hwan Lee, Hussain Mustatab Wahedi, So-Hyeon Baek, Sun Yeou Kim
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28860713/metformin-a-review-of-its-potential-indications
#5
REVIEW
Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian, Qian Huang
Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years, in addition to glucose lowering, several studies have presented evidence suggesting some potential role for metformin, such as antitumor effect, antiaging effect, cardiovascular protective effect, neuroprotective effect or an optional treatment for polycystic ovary syndrome. This paper will critically review the role of metformin to provide reference for doctors and researchers.
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28834114/galangin-suppresses-h2-o2-induced-aging-in-human-dermal-fibroblasts
#6
Su-Ying Wen, Jia-Yi Chen, Yueh-Shan Weng, Ritu Aneja, Chih-Jung Chen, Chih-Yang Huang, Wei-Wen Kuo
Human skin aging is a progressive process that includes intrinsic aging and extrinsic photodamage, both of which can cause an accumulation of reactive oxygen species (ROS), resulting in dermal fibrosis dysfunction and wrinkle formation. Galangin is a flavonoid that exhibits anti-inflammatory and antioxidative potential. Previous studies have reported that galangin has antioxidative activity against ROS-mediated stress. The aim of the present study is to determine the antiaging effects of galangin on dermal fibroblasts exposed to H2 O2 ...
August 18, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28831286/standardized-kaempferia-parviflora-extract-inhibits-intrinsic-aging-process-in-human-dermal-fibroblasts-and-hairless-mice-by-inhibiting-cellular-senescence-and-mitochondrial-dysfunction
#7
Ji-Eun Park, Seon Wook Woo, Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang
Intrinsic skin aging is a complex biological phenomenon mainly caused by cellular senescence and mitochondrial dysfunction. This study evaluated the inhibitory effect of Kaempferia parviflora Wall ex. Baker ethanol extract (KPE) on H2O2-stimulated cellular senescence and mitochondrial dysfunction both in vitro and in vivo. KPE significantly increased cell growth and suppressed senescence-associated β-galactosidase activation. KPE inhibited the expression of cell-cycle inhibitors (p53, p21, p16, and pRb) and stimulated the expression of cell-cycle activators (E2F1 and E2F2)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28768895/p16-ink4a-and-senescence-associated-%C3%AE-galactosidase-can-be-induced-in-macrophages-as-part-of-a-reversible-response-to-physiological-stimuli
#8
Brandon M Hall, Vitaly Balan, Anatoli S Gleiberman, Evguenia Strom, Peter Krasnov, Lauren P Virtuoso, Elena Rydkina, Slavoljub Vujcic, Karina Balan, Ilya I Gitlin, Katerina I Leonova, Camila R Consiglio, Sandra O Gollnick, Olga B Chernova, Andrei V Gudkov
Constitutive p16(Ink4a) expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16(Ink4a)-positive cell killing to the eradication of accumulated SCs. However, detection of p16(Ink4a)/SAβG-positive macrophages in the adipose tissue of old mice and in the peritoneal cavity of young animals following injection of alginate-encapsulated SCs has raised concerns about the exclusivity of these markers for SCs...
August 2, 2017: Aging
https://www.readbyqxmd.com/read/28751929/the-preconditioning-of-berberine-suppresses-hydrogen-peroxide-induced-premature-senescence-via-regulation-of-sirtuin-1
#9
Xiaofei Zhu, Haodi Yue, Xiaofang Guo, Jingyi Yang, Jingshuo Liu, Jiangtao Liu, Ruijie Wang, Wenjuan Zhu
With a long history of application in Chinese traditional medicine, berberine (BBR) was reported to exhibit healthspan-extending properties in some age-related diseases, such as type 2 diabetes and atherosclerosis. However, the antiaging mechanism of BBR is not completely clear. By means of hydrogen peroxide- (H2O2-) induced premature cellular senescence model, we found that a low-concentration preconditioning of BBR could resist premature senescence in human diploid fibroblasts (HDFs) measured by senescence-associated β-galactosidase (SA-β-gal), accompanied by a decrease in loss of mitochondrial membrane potential and production of intracellular reactive oxygen species (ROS)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28733999/retinyl-propionate-and-climbazole-combination-demonstrates-clinical-improvement-to-the-appearance-of-hyperpigmentation-and-deep-wrinkling-with-minimal-irritation
#10
Stacy Hawkins, Jean Adamus, Chung-Yi Chiang, Edwin Covell, Jaime O'Leary, Jian-Ming Lee
OBJECTIVE: To evaluate a combination of retinyl propionate and climbazole (RPC) compared to 0.1% retinol for its efficacy, tolerance and aging appearance. METHOD: Forty-five healthy Caucasian females, ages 40-70, with moderately photodamaged facial skin, were recruited for a 16 week randomized, double-blind, IRB approved facial study. The efficacy of RPC treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split-face product application...
July 22, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28713485/micrornas-and-autophagy-fine-players-in-the-control-of-chondrocyte-homeostatic-activities-in-osteoarthritis
#11
REVIEW
Stefania D'Adamo, Silvia Cetrullo, Manuela Minguzzi, Ylenia Silvestri, Rosa Maria Borzì, Flavio Flamigni
Osteoarthritis (OA) is a debilitating degenerative disease of the articular cartilage with a multifactorial etiology. Aging, the main risk factor for OA development, is associated with a systemic oxidative and inflammatory phenotype. Autophagy is a central housekeeping system that plays an antiaging role by supporting the clearance of senescence-associated alterations of macromolecules and organelles. Autophagy deficiency has been related to OA pathogenesis because of the accumulation of cellular defects in chondrocytes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28701867/effects-of-korean-ginseng-berry-on-skin-antipigmentation-and-antiaging-via-foxo3a-activation
#12
Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Takahiko Shimizu, Jae Youl Cho, Dae Bang Seo, Song Seok Shin
BACKGROUND: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28685671/experimental-models-for-aging-and-their-potential-for-novel-drug-discovery
#13
Jaume Folch, Oriol Busquets, Miren EttchetoElena Sánchez-López, Mercè Pallàs, Carlos Beas-Zarate, Miguel Marin, Gemma Casadesus, Jordi Olloquequi, Carme Auladell, Antoni Camins
The development of antiaging drugs is an interesting area of scientific research. In order to evaluate the beneficial effects of new potential drugs, it is necessary to gather the specific knowledge on the adequate preclinical models that are available. This review focuses on invertebrate and vertebrate preclinical models used to evaluate the efficacy of antiaging compounds, with the objective to extend lifespan and health span. Dietary restriction (DR), a common experimental process to extend lifespan in all organisms, is also discussed...
July 7, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28677983/aronia-berry-extract-ameliorates-the-severity-of-dextran-sodium-sulfate-induced-ulcerative-colitis-in-mice
#14
Sa-Haeng Kang, Yong-Deok Jeon, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Hyun Myung, Jong-Sung Kim, Hyun-Ju Kim, Keuk-Soo Bang, Jong-Sik Jin
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a group of inflammatory conditions of the colon and small intestine. UC is a chronic inflammatory disorder of the colon and rectum that includes intervals of acute exacerbation. Although recent studies have suggested that proinflammatory cytokines might have initiated the inflammatory responses in UC, its etiology remains unclear. Aronia berries are rich in dietary polyphenols such as phenolic acids, anthocyanins, flavonoids, and proanthocyanidins with various health benefits, including antioxidant, anti-inflammatory, and antiaging activities...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28676015/effects-of-resveratrol-and-other-polyphenols-on-sirt1-relevance-to-brain-function-during-aging
#15
F Sarubbo, S Esteban, A Miralles, D Moranta
Classically the oxidative stress and more recently inflammatory processes have been identified as the major causes of brain aging. Oxidative stress and inflammation affect each other, but there is more information about the effects of oxidative stress on aging than regarding the contribution of inflammation on it. In the intense research for methods to delay or mitigate the effects of aging, are interesting polyphenols, natural molecules synthesized by plants (e.g. resveratrol). Their antioxidant and anti-inflammatory properties become them useful molecules in the prevention of aging...
July 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28676006/carnosine-treatment-diminished-oxidative-stress-and-glycation-products-in-serum-and-tissues-of-d-galactose-treated-rats
#16
Fatih Aydin, Esra Betul Kalaz, Canan Kucukgergin, Jale Coban, Semra Dogru-Abbasoglu, Mujdat Uysal
D-galactose (GAL) has been used as an animal model for aging and antiaging studies. GAL stimulates oxidative stress and increases the formation of advanced glycation end products (AGE) in body fluids and tissues. Carnosine (CAR; β-alanil-L-histidine) exhibits antioxidant and anti-glycating properties. We investigated the effect of CAR supplementation on oxidative stress and AGE levels in serum, liver and brain tissues in GAL-treated rats. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with CAR (250 mg/kg/daily; i...
July 3, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28638409/differential-fasting-plasma-glucose-and-ketone-body-levels-in-ghrko-versus-3xtg-ad-mice-a-potential-contributor-to-aging-related-cognitive-status
#17
Chelsea M Griffith, Lauren N Macklin, Andrzej Bartke, Peter R Patrylo
Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimer's disease)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28614949/comparison-of-metrological-techniques-for-evaluation-of-the-impact-of-a-cosmetic-product-containing-hyaluronic-acid-on-the-properties-of-skin-surface
#18
Rahula Janiš, Vladimír Pata, Pavlína Egner, Jana Pavlačková, Andrea Zapletalová, Kristina Kejlová
The aim of this research was to evaluate mutual interchangeability of four principally different biometric instrumental techniques designed for objective measurement of changes in the physical, mechanical, and topographical properties of the skin surface treated with commercial antiaging cosmetic products with hyaluronic acid. The following instrumental devices were used: Visioscope PC 35, Corneometer Multiprobe Adapter MPA 6, Reviscometer RVM 600, and 3D scanner Talysurf CLI 500. The comparison of the individual methods was performed using cluster analysis...
June 14, 2017: Biointerphases
https://www.readbyqxmd.com/read/28609391/promotion-and-marketing-of-bioidentical-hormone-therapy-on-the-internet-a-content-analysis-of-websites
#19
Nese Yuksel, Laetitia Treseng, Bushra Malik, Ubaka Ogbogu
OBJECTIVE: To evaluate the quality of information presented and claims made on websites offering bioidentical hormone therapy (BHT) products or services. METHODS: A quantitative content analysis was completed on 100 websites promoting or offering BHT products or services. Websites were identified through Google search engine from September to October 2013. Search terms included "bioidentical hormone therapy" or "bioidentical progesterone," accompanied by "purchase or buy," "service," or "doctors...
October 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28607935/physical-exercise-as-an-effective-antiaging-intervention
#20
EDITORIAL
N Garatachea, A Santos-Lozano, D C Hughes, A Gómez-Cabello, I Ara
No abstract text is available yet for this article.
2017: BioMed Research International
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