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Pelvic nerve afferent & efferent nerve

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https://www.readbyqxmd.com/read/29618971/novel-neurostimulation-of-autonomic-pelvic-nerves-overcomes-bladder-sphincter-dyssynergia
#1
Wendy Yen Xian Peh, Roshini Mogan, Xin Yuan Thow, Soo Min Chua, Astrid Rusly, Nitish V Thakor, Shih-Cheng Yen
The disruption of coordination between smooth muscle contraction in the bladder and the relaxation of the external urethral sphincter (EUS) striated muscle is a common issue in dysfunctional bladders. It is a significant challenge to overcome for neuromodulation approaches to restore bladder control. Bladder-sphincter dyssynergia leads to undesirably high bladder pressures, and poor voiding outcomes, which can pose life-threatening secondary complications. Mixed pelvic nerves are potential peripheral targets for stimulation to treat dysfunctional bladders, but typical electrical stimulation of pelvic nerves activates both the parasympathetic efferent pathway to excite the bladder, as well as the sensory afferent pathway that causes unwanted sphincter contractions...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29575690/clarification-of-the-innervation-of-the-bladder-external-urethral-sphincter-and-clitoris-a-neuronal-tracing-study-in-female-mongrel-hound-dogs
#2
Mary F Barbe, Sandra M Gomez-Amaya, Danielle M Salvadeo, Neil S Lamarre, Ekta Tiwari, Shalonda Cook, Connor P Glair, Daniel H Jang, Rachel M Ragheb, Akaash Sheth, Alan S Braverman, Michael R Ruggieri
Many studies examining the innervation of genitourinary structures focus on either afferent or efferent inputs, or on only one structure of the system. We aimed to clarify innervation of the bladder, external urethral sphincter (EUS) and clitoris. Retrograde dyes were injected into each end organ in female dogs. Spinal cord, mid-bladder, and spinal, caudal mesenteric, sympathetic trunk and pelvic plexus ganglia were examined for retrograde dye-labeled neurons. Neurons retrogradely labeled from the bladder were found primarily in L7-S2 spinal ganglia, spinal cord lateral zona intermedia at S1-S3 levels, caudal mesenteric ganglia, T11-L2 and L6-S2 sympathetic trunk ganglia, and pelvic plexus ganglia...
March 25, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#3
J J Crook, C B J Brouillard, P P Irazoqui, T A Lovick
OBJECTIVE: Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29279880/pathophysiology-of-the-underactive-bladder
#4
REVIEW
Naoki Aizawa, Yasuhiko Igawa
Underactive bladder (UAB), which has been described as a symptom complex suggestive of detrusor underactivity, is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy, reduced sensation on filling, and slow stream often with storage symptoms. Several causes such as aging, bladder outlet obstruction, diabetes mellitus, neurologic disorders, and nervous injury to the spinal cord, cauda equine, and peripheral pelvic nerve have been assumed to be responsible for the development of UAB...
December 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27322010/a-novel-single-compartment-in-vitro-model-for-electrophysiological-research-using-the-perfluorocarbon-fc-770
#5
M Choudhary, F Clavica, R van Mastrigt, E van Asselt
Electrophysiological studies of whole organ systems in vitro often require measurement of nerve activity and/or stimulation of the organ via the associated nerves. Currently two-compartment setups are used for such studies. These setups are complicated and require two fluids in two separate compartments and stretching the nerve across one chamber to the other, which may damage the nerves. We aimed at developing a simple single compartment setup by testing the electrophysiological properties of FC-770 (a perfluorocarbon) for in vitro recording of bladder afferent nerve activity and electrical stimulation of the bladder...
June 20, 2016: Physiological Research
https://www.readbyqxmd.com/read/27265789/a-three-dimensional-nerve-map-of-human-bladder-trigone
#6
J Todd Purves, Laura Spruill, Eric Rovner, Elyse Borisko, Alden McCants, Elizabeth Mugo, Ainsley Wingard, Thomas C Trusk, Thierry Bacro, Francis M Hughes
AIM: Central efferent and afferent neural pathways to and from the human urinary bladder are well-characterized, but the location and arborization of these nerves as they traverse the serosa, muscularis, and urothelial layers are not clearly defined. The purpose of this study was to create a three dimensional map of the innervation of the human bladder trigone from the extrinsic perivesical adventitial nerve trunks to the urothelium. METHODS: A male and a female human bladder were harvested from fresh frozen cadavers and fixed in formalin...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/26491706/impact-of-bioelectronic-medicine-on-the-neural-regulation-of-pelvic-visceral-function
#7
William C de Groat, Changfeng Tai
Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a U.S. Food and Drug Administered (FDA)-approved therapy for treating disorders of the pelvic viscera, including urinary urgency, urgency-frequency, nonobstructive urinary retention and fecal incontinence. The technique is also being tested experimentally for its efficacy in treating interstitial cystitis, chronic constipation and pelvic pain. The goal of neuromodulation is to suppress abnormal visceral sensations and involuntary reflexes and restore voluntary control...
January 22, 2015: Bioelectronic Medicine
https://www.readbyqxmd.com/read/24825353/urethral-sensation-following-reconstructive-pelvic-surgery
#8
M G Abernethy, C Davis, L Lowenstein, E R Mueller, L Brubaker, K Kenton
INTRODUCTION AND HYPOTHESIS: Most urethral neuromuscular function data focus on efferent rather than afferent innervation. We aimed to determine if changes exist in urethral afferent nerve function before and after reconstructive pelvic surgery (RPS). Secondarily, we compared afferent urethral innervation in women with and without stress urinary incontinence undergoing RPS. METHODS: Participants underwent current perception threshold (CPT) and urethral anal reflex (UAR) testing prior to surgery and again post-operatively...
November 2014: International Urogynecology Journal
https://www.readbyqxmd.com/read/24481868/cyclophosphamide-induced-alterations-of-the-micturition-reflex-in-a-novel-in-situ-urinary-bladder-model-in-the-anesthetized-rat
#9
Patrik Aronsson, Thomas Carlsson, Michael Winder, Gunnar Tobin
AIMS: Cyclophosphamide-induced cystitis alterations have been reported to occur both at efferent and afferent level in the micturition reflex arc. In particular, the stretching of the bladder wall causing urothelial release of ATP has been proposed as one of the pivotal mechanisms causing these alterations. To evaluate functional changes at efferent and afferent levels of the micturition reflex following cyclophosphamide treatment we have applied a novel in situ half bladder rat model...
April 2015: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/24047648/the-use-of-botulinum-toxin-for-the-treatment-of-urologic-pain
#10
REVIEW
Andrew Russell, Rajesh Kavia, Prokar Dasgupta, Arun Sahai
PURPOSE OF REVIEW: Botulinum toxin injections into the bladder have become established in the management of refractory detrusor overactivity and overactive bladder. Mechanism of action of the toxin appears to involve both efferent and afferent nerve pathways, as well as having an antinociceptive effect. Over the years, several reports of its use in refractory bladder pain syndrome and interstitial cystitis have emerged. We review the literature with a view to assessing efficacy and adverse events in this setting...
November 2013: Current Opinion in Urology
https://www.readbyqxmd.com/read/23737201/neural-control-of-renal-function
#11
REVIEW
Edward J Johns, Ulla C Kopp, Gerald F DiBona
The kidney is innervated with efferent sympathetic nerve fibers that directly contact the vasculature, the renal tubules, and the juxtaglomerular granular cells. Via specific adrenoceptors, increased efferent renal sympathetic nerve activity decreases renal blood flow and glomerular filtration rate, increases renal tubular sodium and water reabsorption, and increases renin release. Decreased efferent renal sympathetic nerve activity produces opposite functional responses. This integrated system contributes importantly to homeostatic regulation of sodium and water balance under physiological conditions and to pathological alterations in sodium and water balance in disease...
April 2011: Comprehensive Physiology
https://www.readbyqxmd.com/read/23720131/a-novel-in-situ-urinary-bladder-model-for-studying-afferent-and-efferent-mechanisms-in-the-micturition-reflex-in-the-rat
#12
Patrik Aronsson, Thomas Carlsson, Michael Winder, Gunnar Tobin
AIMS: The search for new animal models to investigate both efferent and afferent levels of the micturition reflex, to better understand urinary dysfunctions, is of great importance. Therefore in this study we developed and characterized, by comparisons with a conventional whole bladder model, a novel in situ model. METHODS: The urinary bladder was carefully prepared and separated, via a midline incision, into two halves all the way to the urethra in pentobarbitone and medetomidine anesthetized male rats...
June 2014: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/23408032/renal-sensory-and-sympathetic-nerves-reinnervate-the-kidney-in-a-similar-time-dependent-fashion-after-renal-denervation-in-rats
#13
Jan Mulder, Tomas Hökfelt, Mark M Knuepfer, Ulla C Kopp
Efferent renal sympathetic nerves reinnervate the kidney after renal denervation in animals and humans. Therefore, the long-term reduction in arterial pressure following renal denervation in drug-resistant hypertensive patients has been attributed to lack of afferent renal sensory reinnervation. However, afferent sensory reinnervation of any organ, including the kidney, is an understudied question. Therefore, we analyzed the time course of sympathetic and sensory reinnervation at multiple time points (1, 4, and 5 days and 1, 2, 3, 4, 6, 9, and 12 wk) after renal denervation in normal Sprague-Dawley rats...
April 15, 2013: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/22886730/neural-pathways-of-somatic-and-visceral-reflexes-of-the-external-urethral-sphincter-in-female-rats
#14
C F Pastelín, R Juárez, M S Damaser, Y Cruz
The external urethral sphincter (EUS) plays a crucial role in maintaining urinary continence. The activity of the EUS is modulated by bladder and urethra sensory neurons. However, a complete understanding of the somatic or visceral sources that modulate the EUS is lacking. The aims of the present study were to characterize the response of the EUS to perineal skin, genital, rectal, and urethral mechanical stimulation, as well as to determine the peripheral neural pathways of the reflex. EUS reflex electromyographic activity (EMG), innervation of pelvic and perineal structures, and the anatomy of afferent and efferent nerves were determined in anesthetized female rats...
October 1, 2012: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/22819110/cause-of-residual-urine-in-bladder-outlet-obstruction-an-experimental-study-in-the-rat
#15
Jianwen Zeng, Chuzao Pan, Chonghe Jiang, Sivert Lindström
PURPOSE: We explored the role of bladder mechanoreceptors in post-void residual urine in rats with bladder outlet obstruction. MATERIALS AND METHODS: Partial bladder outlet obstruction was induced by a urethral ligature in 11 adult female Sprague-Dawley® rats. Nine sham operated rats served as controls. The outcome was evaluated in acute experiments using α-chloralose anesthesia 6 weeks later. Bladders were catheterized for infusion, pressure recording and intravesical electrical stimulation...
September 2012: Journal of Urology
https://www.readbyqxmd.com/read/22426756/alterations-in-peripheral-purinergic-and-muscarinic-signaling-of-rat-bladder-after-long-term-fructose-induced-metabolic-syndrome
#16
Shiu-Dong Chung, Chiang-Ting Chien, Hong-Jeng Yu
PURPOSE: We explored the pathophysiologic mechanisms of long-term fructose-induced lower urinary tract symptoms (LUTS) in rats. METHODS: Male Wistar rats were fed with fructose for 3 or 6 months. Biochemical and transcystometric parameters were compared between fructose-fed and age-matched normal-diet rats. Pelvic nerve and external urethral sphincter-electromyogram activity recordings were performed to investigate fructose effects on neural control of bladders...
February 2013: European Journal of Nutrition
https://www.readbyqxmd.com/read/22271337/-sacral-neuromodulation-in-urology-development-and-current-status
#17
REVIEW
T Schwalenberg, J-U Stolzenburg, C Kriegel, A Gonsior
Sacral neuromodulation (SNM) in urology is employed to treat refractory lower urinary tract dysfunction as well as chronic pelvic pain. Electrical stimulation of the sacral afferents (S2 - S4) causes activation and conditioning of higher autonomic and somatic neural structures and thereby influences the efferents controlling the urinary bladder, the rectum and their related sphincter systems. It is therefore possible to treat overactivity as well as hypocontractility and functional bladder neck obstruction...
January 2012: Aktuelle Urologie
https://www.readbyqxmd.com/read/22215714/tonic-postganglionic-sympathetic-inhibition-induced-by-afferent-renal-nerves
#18
Tilmann Ditting, Wolfgang Freisinger, Kirsten Siegel, Christian Fiedler, Lisa Small, Winfried Neuhuber, Sonja Heinlein, Peter W Reeh, Roland E Schmieder, Roland Veelken
Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism. Anesthetized Sprague-Dawley rats were instrumented as follows: (1) arterial and venous catheters for recording of blood pressure and heart rate and drug administration; (2) left-sided renal arterial catheter for selective intrarenal administration of the TRPV1 agonist capsaicin (3...
February 2012: Hypertension
https://www.readbyqxmd.com/read/22178333/selective-plasticity-of-primary-afferent-innervation-to-the-dorsal-horn-and-autonomic-nuclei-following-lumbosacral-ventral-root-avulsion-and-reimplantation-in-long-term-studies
#19
COMPARATIVE STUDY
Lisa Wu, Jun Wu, Huiyi H Chang, Leif A Havton
Previous studies involving injuries to the nerves of the cauda equina and the conus medullaris have shown that lumbosacral ventral root avulsion in rat models results in denervation and dysfunction of the lower urinary tract, retrograde and progressive cell death of the axotomized motor and parasympathetic neurons, as well as the emergence of neuropathic pain. Root reimplantation has also been shown to ameliorate several of these responses, but experiments thus far have been limited to studying the effects of lesion and reimplantation local to the lumbosacral region...
February 2012: Experimental Neurology
https://www.readbyqxmd.com/read/22154753/a-gentle-mechanical-skin-stimulation-technique-for-inhibition-of-micturition-contractions-of-the-urinary-bladder
#20
Harumi Hotta, Koichi Masunaga, Shogo Miyazaki, Nobuhiro Watanabe, Yutaka Kasuya
Effects of gentle skin stimulation of various segmental areas on the micturition contractions of the urinary bladder were examined in anesthetized male rats. The bladder was expanded by infusing saline via urethral cannula until the bladder produced rhythmic micturition contractions as a consequence of rhythmic burst discharges of vesical pelvic efferent nerves. Gentle stimulation was applied for 1 min by slowly rolling on top of skin with an elastomer "roller". Rolling on the perineal area inhibited both micturition contractions and pelvic efferent discharges during and after stimulation...
April 3, 2012: Autonomic Neuroscience: Basic & Clinical
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