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endoleak biomarker

Joseph V Moxon, Eugene Ng, Sharon M Lazzaroni, Margaret Boult, Ramesh Velu, Robert A Fitridge, Jonathan Golledge
OBJECTIVE: Endoleak is a common complication of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) but can be detected only through prolonged follow-up with repeated aortic imaging. This study examined the potential for circulating matrix metalloproteinase 9 (MMP9), osteoprotegerin (OPG), D-dimer, homocysteine (HCY), and C-reactive protein (CRP) to act as diagnostic markers for endoleak in AAA patients undergoing elective EVAR. METHODS: Linear mixed-effects models were constructed to assess differences in AAA diameter after EVAR between groups of patients who did and did not develop endoleak during follow-up, adjusting for potential confounders...
August 23, 2017: Journal of Vascular Surgery
A Ascoli Marchetti, G Pratesi, L Di Giulio, M Battistini, R Massoud, A Ippoliti
INTRODUCTION: The aim of our study is to verify the role of metalloproteinases in endovascular repair (EVAR) and OPEN surgery treatment for abdominal aortic aneurysm (AAA). Postoperatively, these enzymes could represent an important biomarker to adapt diagnostic tests and further investigations during follow-up. MATERIAL AND METHOD: From 2004 to 2008, 55 patients were considered with AAA. Of these, 33 patients (mean age: 70.1 years), (mean AAA diameter: 5.4cm) were treated with OPEN surgery (group A) and 22 (mean age: 74...
February 2017: Journal de Médecine Vasculaire
Rolf Alexander Jánosi, Riccardo Gorla, Konstantinos Tsagakis, Philipp Kahlert, Michael Horacek, Florian Bruckschen, Daniel-Sebastian Dohle, Heinz Jakob, Thomas Schlosser, Holger Eggebrecht, Eduardo Bossone, Raimund Erbel
PURPOSE: To analyze an 11-year single-center experience of treating complicated penetrating aortic ulcer (PAU) using thoracic endovascular aortic repair (TEVAR). METHODS: This study included 63 consecutive patients (mean age 69.1±11.5 years; 40 men) with complicated PAU (42 symptomatic, 22 with rupture) who underwent TEVAR between 2002 and 2013. The PAUs were located in the aortic arch (n=11), the descending thoracic aorta (n=43), and the thoracoabdominal aorta (n=9)...
February 2016: Journal of Endovascular Therapy
Balachundar Subramaniam, Nina Singh, Christopher Roscher, John G T Augoustides
Patients with an abdominal aortic aneurysm (AAA) could benefit from earlier diagnosis to improve long-term outcomes. Candidate serum biomarkers for earlier AAA diagnosis include D-dimer, fibrinogen, low-density lipoprotein, high-density lipoprotein, lipoprotein(a), and the proteolytic enzymes known as matrix metalloproteinases. Furthermore, biomarkers such as brain natriuretic peptide significantly stratify perioperative risk in AAA repair. Statins significantly improve outcomes after AAA repair. They may also significantly slow AAA growth to allow pharmacologic arrest of AAA development...
October 2012: Journal of Cardiothoracic and Vascular Anesthesia
Niharika Kamat, Kim Lien-Thi Nguyen-Ehrenreich, Steven H Hsu, Alex P Ma, Irene Sinn, Leslie Coleman, Julie Tai
PURPOSE: To develop an ex-vivo arterial perfusion model to evaluate vascular responses to bare metal stents (BMS) and drug-eluting stents (DES) in porcine carotid arteries. MATERIALS AND METHODS: Porcine carotid arteries with BMS or DES were cultured under hemodynamic stimuli for 24 hours and 72 hours. Vascular responses of arteries with stents were assessed by cellular functionality and gene expression and compared with a noninjured (NI) control group at each time point...
February 2011: Journal of Vascular and Interventional Radiology: JVIR
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