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https://www.readbyqxmd.com/read/29131706/alzheimer-s-disease-current-status-and-future-directions
#1
Deepshikha Bhardwaj, Connie Mitra, Chandrakala Aluganti Narasimhulu, Aladdin Riad, Mitsushita Doomra, Sampath Parthasarathy
Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the brain. The presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), loss of neurons, synapses, and altered sensory perceptions, including memory loss, delineate AD. However, the cause of AD is not clearly known. Several genetic and nongenetic factors have been implicated in the disease. Of the genes, the ɛ4 allele of apolipoprotein E is the largest known genetic risk factor of AD. This review article focuses on the various genetic and other predisposing factors that account for AD, pathophysiology of the disease, and the mechanisms by which Aβ plaques and NFTs are formed and could affect AD brain...
November 13, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29090488/validation-of-keratometric-measurements-obtained-with-an-intraoperative-image-guided-system-intra-session-repeatability-and-interchangeability-with-an-optical-biometer
#2
Clara Ruiz-Belda, Fermín Rodrigo, David P Piñero
PURPOSE: To evaluate the intra-session repeatability of keratometric measurements obtained in healthy eyes with the Verion image-guided system (Alcon Laboratories Inc, Fort Worth, Texas, USA) as well as the interchangeability of such measurements with those obtained with an optical biometer (Aladdin, Topcon, Tokyo, Japan). METHODS: A total of 53 eyes of 53 patients (age 31-67 years) were enrolled in the study. All eyes received a comprehensive ophthalmologic examination including an analysis with the Verion image-guided and Aladdin systems...
October 31, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29072621/synthesis-and-2d-qsar-study-of-active-benzofuran-based-vasodilators
#3
Nagy M Khalifa, Aladdin M Srour, Somaia S Abd El-Karim, Dalia O Saleh, Mohamed A Al-Omar
A new series of 2-alkyloxy-pyridine-3-carbonitrile-benzofuran hybrids (4a-x) was synthesized. All the new derivatives were examined via the standard technique for their vasodilation activity. Some of the investigated compounds exhibited a remarkable activity, with compounds 4w, 4e, 4r, 4s, 4f and 4g believed to be the most active hits in this study with IC50 values 0.223, 0.253, 0.254, 0.268, 0.267 and 0.275 mM, respectively, compared with amiodarone hydrochloride, the reference standard used (IC50 = 0.300 mM)...
October 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29064770/managing-titanium-mesh-exposure-with-the-partial-removal-of-the-exposed-site-a-case-series-study
#4
Aladdin Al-Ardah, Abdulaziz AlHelal, Periklis Proussaefs, Bader AlBader, Abdulakareem A Al Humaidan, Jaime Lozada
This case series report aimed at evaluating the efficacy of addressing exposure of the Titanium mesh by sectioning the exposed portion of the mesh and allowing the remaining portion in place while bone maturation is complete. The use of Titanium mesh for localized alveolar ridge augmentation was evaluated with clinical and radiographic analysis. Materials and methods in the current case series report includes four consecutively treated patients where a titanium mesh was utilized as a barrier for localized alveolar ridge augmentation and exposure of the mesh occurred after the alveolar ridge augmentation procedure...
October 24, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28979276/effects-of-temperature-stresses-on-the-resistance-of-chickpea-genotypes-and-aggressiveness-of-didymella-rabiei-isolates
#5
Seid Ahmed Kemal, Sanae Krimi Bencheqroun, Aladdin Hamwieh, Muhammad Imtiaz
Chickpea (Cicer arietinum L.) is an important food and rotation crop in many parts of the world. Cold (freezing and chilling temperatures) and Ascochyta blight (Didymella rabiei) are the major constraints in chickpea production. The effects of temperature stresses on chickpea susceptibility and pathogen aggressiveness are not well documented in the Cicer-Didymella pathosystem. Two experiments were conducted under controlled conditions using chickpea genotypes and pathogen isolates in 2011 and 2012. In Experiment 1, four isolates of D...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28973844/rituximab-for-the-treatment-of-adult-onset-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura
#6
Federica Maritati, Roberta Fenoglio, Evangeline Pillebout, Giacomo Emmi, Maria L Urban, Rossana Rocco, Maria Nicastro, Monia Incerti, Matteo Goldoni, Giorgio Trivioli, Elena Silvestri, Aladdin J Mohammad, David Jayne, Per Eriksson, Mårten Segelmark, Pavel Novikov, Helen Harris, Dario Roccatello, Augusto Vaglio
OBJECTIVE: Adult-onset IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a rare systemic vasculitis characterised by IgA1-dominant deposits. The treatment of adult-onset IgAV is controversial and is based on the combination of glucocorticoids and immunosuppressive agents, but many patients have refractory or relapsing disease despite treatment. Rituximab is a B cell-depleting antibody of proven efficacy in anti-neutrophil cytoplasmic antibody-associated vasculitis. We tested the efficacy and safety of rituximab in a multicentre cohort of patients with adult-onset IgAV...
October 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28973836/general-and-abdominal-obesity-as-risk-factors-for-late-life-mobility-limitation-after-total-knee-or-hip-replacement-for-osteoarthritis-among-women
#7
Aladdin H Shadyab, Wenjun Li, Charles B Eaton, Andrea Z LaCroix
OBJECTIVE: To investigate associations of body mass index (BMI), waist circumference (WC), and waist-hip ratio (WHR) with survival to age 85 with mobility limitation or death before age 85 among older women with total knee (TKR) or total hip (THR) replacement for osteoarthritis. METHODS: This was a prospective study of women (aged 65-79 years at baseline) from the Women's Health Initiative recruited during 1993-1998 and followed through 2012. Women's Health Initiative data were linked to Medicare claims data to determine TKR (n=1,867) and THR (n=944) for osteoarthritis...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28955485/long-term-patient-survival-in-a-swedish-population-based-cohort-of-patients-with-anca-associated-vasculitis
#8
Caroline Heijl, Aladdin J Mohammad, Kerstin Westman, Peter Höglund
OBJECTIVES: Patients with antineutrophil cytoplasmatic antibodies-associated vasculitides (AAV) exhibit higher mortality than the general population. In the current study, we assessed whether cluster affiliation based on clinical presentation might predict mortality. METHODS: With case record review, the outcomes for a population-based cohort of patients diagnosed with AAV in southern Sweden (catchment area of 0.7 million inhabitants) between 1997 and 2010 were assessed...
2017: RMD Open
https://www.readbyqxmd.com/read/28939832/inherent-humic-substance-promotes-microbial-denitrification-of-landfill-leachate-via-shifting-bacterial-community-improving-enzyme-activity-and-up-regulating-gene
#9
Shanshan Dong, Mu Li, Yinguang Chen
Microbial denitrification is the main pathway for nitrogen removal of landfill leachate. Although humic substances (HSs) have been reported in landfill leachate, the effects of HS on denitrification process of activated sludge for leachate treatment are still unknown. In this study, we adopted SAHA as the model HS to study the effects of HS on the denitrification of landfill leachate. After long-term operation at 10 mg/L of Shanghai Aladdin Humic Acid (SAHA), the final nitrate concentration and nitrite accumulation were much lower than the control (5...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845411/leech-therapy-for-treating-priapism-case-report
#10
Sayed Aladdin Asgari, Sadeq Rostami, Mojtaba Teimoori
Priapism is well-defined by persistent, painful penile erection which happens without sexual stimulation. Currently, the hirudotherapy is practiced to treat venous congestion and subsequent compartment syndrome. Here we will report a case of a male with priapism treated by leeches. The case was a 26 yr old young single male referred to the Razi Hospital Emergency Department, Guilan University of Medical Sciences, Rasht, Iran due to long-time spontaneous erections. The patient had no history of mental disorders, trauma or sickle cell anemia...
July 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28831342/diagnostic-accuracy-of-lymphoscintigraphy-for-lymphedema-and-analysis-of-false-negative-tests
#11
Aladdin H Hassanein, Reid A Maclellan, Frederick D Grant, Arin K Greene
Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. Diagnosis is made by history and physical examination and confirmed with lymphoscintigraphy. The purpose of this study was to assess the accuracy of lymphoscintigraphy for the diagnosis of lymphedema and to determine characteristics of patients with false-negative tests. METHODS: Individuals referred to our lymphedema program with "lymphedema" between 2009 and 2016 were analyzed. Subjects were assessed by history, physical examination, and lymphoscintigraphy...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28827482/insulin-neuritis-and-effect-of-pregabalin
#12
Yasser Aladdin, Thomas Jeerakathil, Zaeem A Siddiqi
INTRODUCTION: Insulin neuritis (IN) is a rare condition that results in acute painful neuropathy. It occurs classically in patients with diabetes mellitus with uncontrolled sugar levels who are started on insulin therapy leading to a precipitous normalization of blood sugar levels. The condition is heralded by severe and generalized burning pain along with significant weight loss and mood issues. The diagnosis is mainly clinical and the etiology of IN remains obscure. METHODS AND RESULTS: We report on 2 cases who developed acute and excruciating neuropathic pain after institution of insulin therapy for poorly controlled diabetes mellitus...
September 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28765251/severe-infection-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#13
Aladdin J Mohammad, Mårten Segelmark, Rona Smith, Martin Englund, Jan-Åke Nilsson, Kerstin Westman, Peter A Merkel, David R W Jayne
OBJECTIVE: To compare the rate of severe infections after the onset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with the rate in the background population, and to identify predictors of severe infections among patients with AAV. METHODS: The study cohort was 186 patients with AAV diagnosed from 1998 to 2010, consisting of all known cases in a defined population in southern Sweden. For each patient, 4 age-and sex-matched reference subjects were randomly chosen from the background population...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28765242/pulmonary-involvement-in-antineutrophil-cytoplasmic-antibodies-anca-associated-vasculitis-the-influence-of-anca-subtype
#14
Aladdin J Mohammad, Kristian H Mortensen, Judith Babar, Rona Smith, Rachel B Jones, Daiki Nakagomi, Pasupathy Sivasothy, David R W Jayne
OBJECTIVE: To describe pulmonary involvement at time of diagnosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), as defined by computed tomography (CT). METHODS: Patients with thoracic CT performed on or after the onset of AAV (n = 140; 75 women; granulomatosis with polyangiitis, n = 79; microscopic polyangiitis MPA, n = 61) followed at a tertiary referral center vasculitis clinic were studied. Radiological patterns of pulmonary involvement were evaluated from the CT studies using a predefined protocol, and compared to proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA specificity...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28675421/associations-between-self-reported-physical-activity-and-physical-performance-measures-over-time-in-postmenopausal-women-the-women-s-health-initiative
#15
MULTICENTER STUDY
Deepika R Laddu, Betsy C Wertheim, David O Garcia, Robert Brunner, Erik Groessl, Aladdin H Shadyab, Scott B Going, Michael J LaMonte, Brad Cannell, Meryl S LeBoff, Jane A Cauley, Cynthia A Thomson, Marcia L Stefanick
OBJECTIVES: To examine prospective associations between changes in physical activity (PA) and changes in physical performance measures (PPMs) over 6 years in older women. DESIGN: Prospective cohort study. SETTING: Forty clinical centers in the United States. PARTICIPANTS: Women aged 65 and older (mean age 69.8) enrolled in the Women's Health Initiative Clinical Trials with gait speed, timed chair stand, grip strength, and self-reported recreational PA data assessed at baseline (1993-98) and follow-up Years 1, 3, and 6 (N = 5,092)...
October 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28552815/leisure-time-physical-activity-and-leukocyte-telomere-length-among-older-women
#16
Aladdin H Shadyab, Michael J LaMonte, Charles Kooperberg, Alexander P Reiner, Cara L Carty, Todd M Manini, Lifang Hou, Chongzhi Di, Caroline A Macera, Linda C Gallo, Richard A Shaffer, Sonia Jain, Andrea Z LaCroix
BACKGROUND: Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults. METHODS: In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28521723/hiv-aids-securitization-outcomes-and-current-challenges
#17
Aladdin H Shadyab, Braden R Hale, Richard A Shaffer
BACKGROUND: The securitization (i.e., framing of a health issue as a security threat) of HIV/AIDS by the United Nations Security Council in 2000 changed the belief that HIV/AIDS is only a health issue. Although now accepted that HIV/AIDS represents a security threat, the consequences of securitization are still not widely established. METHODS: The purpose of this paper was to present an evidence-based review of the outcomes and current challenges associated with HIV/AIDS securitization in the context of national security...
May 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28521721/the-importance-of-military-conscripts-for-surveillance-of-human-immunodeficiency-virus-infection-and-risk-behavior-in-thailand
#18
Kenrad Nelson, Ram Rangsin
BACKGROUND: The epidemic of human immunodeficiency virus (HIV) infection in Thailand began in 1988 among injection drug users (IDUs) in Bangkok. It soon spread to other populations, especially female sex workers (FSWs) and men attending STD clinics. Routine serologic surveillance for HIV began among military conscripts in 1991. The HIV seroprevalence data from military conscripts provided national surveillance data, since the entire population of 21 year old men were conscripted for 2 years' service in the military by a random process during which 10% of men were selected...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28521716/building-a-successful-military-to-military-partnership-through-confronting-hiv-the-u-s-nigeria-experience
#19
Darrell E Singer, Robbie Nelson, C M Smith, Tahir O Umar, Ogbonnaya Simon Njoku
The Nigerian Ministry of Defence-Walter Reed Army Institute of Research partnership was established in 2004 in response to the growing HIV/AIDS epidemic in Nigeria. Here we discuss the emergence of HIV in Nigeria, highlighting the initial barriers to treatment delivery, and outline the origins of the international military-to-military partnership developed to confront the disease. With financial support from the United States President's Plan for AIDS Relief and Nigerian Government Counterpart Funding, we demonstrate how this program led to a successful and sustainable response in the fight against HIV in Nigeria...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28498154/pediatric-to-adult-transition-and-medication-adherence-in-patients-with-inflammatory-bowel-disease
#20
Jayson Jeganathan, Cheng Hiang Lee, Antony Rahme, Darren K Tiao, Celine Weston, Shoma Dutt, Annabel Magoffin, Vu Kwan, Aladdin Alswaifi, Peter H Katelaris, Kevin J Gaskin, Edward V OʼLoughlin, Rupert W Leong
BACKGROUND: Medication nonadherence is common in inflammatory bowel disease and is associated with poor outcomes. There has been no study on pediatric-to-adult transition as a risk factor for nonadherence in inflammatory bowel disease, which has been demonstrated in other diseases. We aimed to assess whether transitioned (TR) patients have higher nonadherence rates than young adults (YAs) diagnosed in adulthood. METHODS: Consecutive ambulatory subjects were prospectively recruited and completed the validated Medication Adherence Reporting Scale (MARS), with the primary outcome being adherence differences between group age-matched TR and YA groups...
July 2017: Inflammatory Bowel Diseases
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