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Female urinary dysfunction

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https://www.readbyqxmd.com/read/28106785/ketamine-analog-methoxetamine-induced-inflammation-and-dysfunction-of-bladder-in-rats
#1
Qiang Wang, Qinghui Wu, Junpeng Wang, Yang Chen, Guihao Zhang, Jiawei Chen, Jie Zhao, Peng Wu
The novel synthetic psychoactive ketamine analog methoxetamine is reportedly being used for recreational purposes. As ketamine use can result in urinary dysfunction, we conducted the present study to investigate how methoxetamine affects the bladder. A cystometry investigation showed that female Sprague-Dawley rats experienced increased micturition frequency bladder dysfunction after receiving a daily intraperitoneal injection of 30 mg/kg methoxetamine or ketamine for periods of 4 or 12 weeks. Histologic examinations of rat bladder tissue revealed damaged urothelium barriers, as well as evidence of inflammatory cell infiltration and matrix deposition...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098112/autosomal-dominant-polycystic-kidney-disease-study-of-clinical-characteristics-in-an-indian-population
#2
Sanjay Vikrant, Anupam Parashar
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary form of kidney disease. Clinical data on this multisystem disorder are scarce from developing countries. We conducted a prospective observational study of the clinical profile of ADPKD patients at a single center over a period of six years. A total of 208 patients were studied. Majority were male (60.6%) and the mean age was 45.8 ± 14.5 years. About 61.5% had early stage (Stages 1-3) of chronic kidney disease (CKD) and 38.5% had advanced CKD (Stages 4 and 5)...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28091440/nocturnal-enuresis-in-school-aged-children-with-sickle-cell-anemia-any-relationship-with-hyposthenuria
#3
C I Eneh, A N Ikefuna, H U Okafor, S N Uwaezuoke
BACKGROUND: Reports show that children with sickle-cell anemia (SCA) have a tendency for nocturnal enuresis when compared with their counterparts with normal hemoglobin. Although nocturnal enuresis in SCA has been attributed to several factors including tubular and even bladder dysfunction, its relationship with hyposthenuria has been questioned in some studies. AIM: The study aims to determine the relationship of hyposthenuria with nocturnal enuresis seen in school-aged children with SCA...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28087237/what-is-the-real-impact-of-urinary-incontinence-on-female-sexual-dysfunction-a-case-control-study
#4
Mariana Rhein Felippe, Joao Paulo Zambon, Marcia Eli Girotti, Juliana Schulze Burti, Claudia Rosenblatt Hacad, Lina Cadamuro, Fernando Almeida
INTRODUCTION: Urinary incontinence (UI) has been associated with negative effects on women's sexuality. Women's sexuality and sexual function are a complex issue, and the role of UI is not completely clear. AIM: To assess the impact of UI on female sexual function by comparing this population with a control group of continent women. METHODS: We performed a case-control study from August 2012 to September 2013. We evaluated continent and incontinent women (age range = 30-70 years) for their sexuality...
January 10, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28058715/body-mass-index-based-evaluation-of-6-year-outcomes-after-transobturator-tension-free-vaginal-tape-for-female-urinary-incontinence
#5
Ahmet Salvarcı, Recai Gurbuz
INTRODUCTION: The long-term results will be presented according to the body mass index (BMI) rates for transobturator tension-free vaginal. METHODS: Three hundred nineteen female patients were evaluated (2008-2014). Their incontinence was classified according to the Stamey classification. The International Consultation on Incontinence Questionnaire-Short form was filled in before and after surgery. The Pelvic Organ Prolapse quantification system was utilized. The Female Sexual Function Index and the International Index of Erectile Functions were asked to be filled in...
December 29, 2016: Urologia
https://www.readbyqxmd.com/read/28039004/localized-inhibition-of-p2x7r-at-the-spinal-cord-injury-site-improves-neurogenic-bladder-dysfunction-by-decreasing-urothelial-p2x3r-expression-in-rats
#6
Alvaro Munoz, Iman K Yazdi, Xiufeng Tang, Carolina Rivera, Nima Taghipour, Robert G Grossman, Timothy B Boone, Ennio Tasciotti
AIMS: Reestablishment of bladder function in patients with spinal cord injury (SCI) is a clinical priority. Our objectives were to determine whether SCI-localized inhibition of purinergic P2X7 receptors (P2X7R) improve bladder function by decreasing afferent signals mediated by urothelial P2X3R. MAIN METHODS: Systemic inhibition of P2X7R may improve locomotion in rodent SCI models; however, beneficial effects on bladder function and its physiological mechanisms have not been evaluated...
December 27, 2016: Life Sciences
https://www.readbyqxmd.com/read/28005595/pelvic-floor-ultrasound-a-review
#7
Hans Peter Dietz
Female pelvic floor dysfunction encompasses a number of prevalent conditions and includes pelvic organ prolapse, urinary and fecal incontinence, obstructed defecation, and sexual dysfunction. In most cases neither etiology nor pathophysiology are well understood. Imaging has great potential to enhance both research and clinical management capabilities, and to date this potential is underutilized. Of the available techniques such as x-ray, computed tomography, magnetic resonance imaging, and ultrasound, the latter is generally superior for pelvic floor imaging, especially in the form of perineal or translabial imaging...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27990783/radiation-exposure-during-videourodynamics-establishing-risk-factors
#8
Benjamin M Brucker, Lysanne Campeau, Eva Fong, Sidhartha Kalra, Nirit Rosenblum, Victor W Nitti
OBJECTIVES: The use of fluoroscopy during urodynamics can be helpful in the evaluation of patients with lower urinary tract dysfunction. However, fluoroscopy introduces the potential hazards of ionizing radiation, including malignancy. In this study we analyzed the data for radiation exposure during videourodynamic study (VUDS) at our center; we have also tried to establish the factors associated with increased exposure to radiation during VUDS. METHODS: We reviewed all VUDS from August 2010 to May 2011...
December 19, 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/27986585/sexual-functioning-of-men-and-women-with-severe-obesity-before-bariatric-surgery
#9
Kristine J Steffen, Wendy C King, Gretchen E White, Leslee L Subak, James E Mitchell, Anita P Courcoulas, David R Flum, Gladys Strain, David B Sarwer, Ronette L Kolotkin, Walter Pories, Alison J Huang
BACKGROUND: Obesity may impair sexual function through multiple mechanisms, but little is known about sexual dysfunction among adults with severe obesity seeking bariatric procedures. OBJECTIVES: To describe sexual function and associated factors before bariatric surgery. SETTING: Ten U.S. clinical facilities. METHODS: Before bariatric surgery, 2225 of 2458 Longitudinal Assessment of Bariatric Surgery-2 study participants (79% female, median age 45 years and median body mass index 46 kg/m(2)) completed a survey about sexual function over the past month...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27965420/microalbuminuria-in-subjects-with-copd-relationship-to-the-new-version-of-global-initiative-for-chronic-obstructive-lung-disease-staging
#10
Fulsen Bozkus, Nursel Dikmen, Anil Samur
BACKGROUND: Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality for any reason and of cardiovascular events. Recent research on the management of COPD has focused more on comorbidities, including cardiovascular events. The objective of this study was to investigate the incidence of microalbuminuria and whether it is associated with physiological and clinical features in a subject group that was classified in line with the new version of the Global Initiative for Chronic Obstructive Lung Disease stages...
December 13, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27935651/epidemiology-of-diabetic-kidney-disease-in-adult-patients-with-type-1-diabetes-in-italy-the-amd-annals-initiative
#11
Antonio Pacilli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
BACKGROUND: Patients with type 1 diabetes mellitus are at increased risk of death. This risk appears to be modulated by kidney dysfunction. Aim of this study was to evaluate the prevalence of diabetic kidney disease (DKD), its traits and clinical correlates in a large sample of patients with type 1 diabetes. METHODS: Clinical data of 20,464 patients with type 1 diabetes were extracted from electronic medical records. Estimated glomerular filtration rate (eGFR) and increased urinary albumin excretion were considered...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27924379/relationship-between-pelvic-floor-muscle-strength-and-sexual-dysfunction-in-postmenopausal-women-a-cross-sectional-study
#12
Maíra de Menezes Franco, Patricia Driusso, Kari Bø, Daniela Cristina Carvalho de Abreu, Lucia Alves da Silva Lara, Ana Carolina Japur de Sá Rosa E Silva, Cristine Homsi Jorge Ferreira
INTRODUCTION AND HYPOTHESIS: The prevalence of sexual dysfunction in postmenopausal women is high. Theoretically pelvic floor muscle (PFM) strength could influence sexual function, but to date there is scant evidence on this topic. The aim of this study was to evaluate the relationship between PFM strength and sexual function in postmenopausal women. The relationship between reported urinary incontinence (UI) and sexual dysfunction was also investigated. METHODS: This was a cross-sectional study including 113 postmenopausal women...
December 6, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27913261/typical-symptoms-of-normal-pressure-hydrocephalus-caused-by-choroid-plexus-papilloma-in-the-cerebellopontine-angle
#13
Hiroshi Ito, Yukiko Nakahara, Masatou Kawashima, Jun Masuoka, Tatsuya Abe, Toshio Matsushima
BACKGROUND: Choroid plexus papillomas (CPPs) are rare benign intracranial tumors. We report a rare case of CPP manifesting with typical symptoms of normal-pressure hydrocephalus rather than obstructive hydrocephalus. CASE DESCRIPTION: A 45-year-old woman presented with a 6-year history of headache and typical symptoms of normal-pressure hydrocephalus, including gait disturbance, urinary incontinence, and cognitive dysfunction, in addition to the more common symptoms of CPP, such as lower cranial nerve dysfunctions and ataxia...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27887914/practical-and-functional-classification-of-the-double-urethra-a-variable-complex-and-fascinating-malformation-observed-in-20-patients
#14
M Lima, F Destro, M Maffi, D Persichetti Proietti, G Ruggeri
INTRODUCTION: Urethral duplication is a rare and variable malformation of the urinary tract, with non-univocal and complex management. In addition, different classification schemes have been proposed, but none have considered all the possible variants. OBJECTIVE: To report experience with the management of 20 urethral duplication patients and propose a classification of this anomaly. MATERIALS AND METHODS: A retrospective analysis collecting information regarding 20 patients (Table) with urethral duplication treated at a single institution over the past 40 years...
November 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887601/protocol-for-a-prospective-randomized-study-on-neurophysiological-assessment-of-lower-urinary-tract-function-in-a-healthy-cohort
#15
Stéphanie van der Lely, Martina Stefanovic, Melanie R Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D Liechti, Martin Schubert, Thomas M Kessler, Ulrich Mehnert
BACKGROUND: Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproducible assessment of afferent nerve function of the lower urinary tract are missing. Previous studies showed first feasibility results of sensory evoked potential recordings following electrical stimulation of the lower urinary tract in healthy subjects and patients. Nevertheless, a refinement of the methodology is necessary...
November 25, 2016: BMC Urology
https://www.readbyqxmd.com/read/27828991/loss-of-mecp2-causes-urological-dysfunction-and-contributes-to-death-by-kidney-failure-in-mouse-models-of-rett-syndrome
#16
Christopher S Ward, Teng-Wei Huang, José A Herrera, Rodney C Samaco, Meagan R Pitcher, Alan Herron, Steven A Skinner, Walter E Kaufmann, Daniel G Glaze, Alan K Percy, Jeffrey L Neul
Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of acquired skills during development, autonomic dysfunction, and an increased risk for premature lethality. Clinical experience identified a subset of individuals with RTT that present with urological dysfunction including individuals with frequent urinary tract infections, kidney stones, and urine retention requiring frequent catheterization for bladder voiding. To determine if urologic dysfunction is a feature of RTT, we queried the Rett Syndrome Natural History Study, a repository of clinical data from over 1000 individuals with RTT and found multiple instances of urological dysfunction...
2016: PloS One
https://www.readbyqxmd.com/read/27824705/correlation-between-echodefecography-and-3-dimensional-vaginal-ultrasonography-in-the-detection-of-perineal-descent-in-women-with-constipation-symptoms
#17
Sthela M Murad-Regadas, Francisco Sergio Pinheiro Regadas, Lusmar V Rodrigues, Adjra da Silva Vilarinho, Guilherme Buchen, Livia Olinda Borges, Lara B Veras, Mariana Murad da Cruz
BACKGROUND: Defecography is an established method of evaluating dynamic anorectal dysfunction, but conventional defecography does not allow for visualization of anatomic structures. OBJECTIVE: The purpose of this study was to describe the use of dynamic 3-dimensional endovaginal ultrasonography for evaluating perineal descent in comparison with echodefecography (3-dimensional anorectal ultrasonography) and to study the relationship between perineal descent and symptoms and anatomic/functional abnormalities of the pelvic floor...
December 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27807040/a-combined-intervention-of-zinc-multiple-micronutrients-and-albendazole-does-not-ameliorate-environmental-enteric-dysfunction-or-stunting-in-rural-malawian-children-in-a-double-blind-randomized-controlled-trial
#18
Alfred Z Wang, Robert J Shulman, Audrey H Crocker, Chrissie Thakwalakwa, Kenneth M Maleta, Sridevi Devaraj, Mark J Manary, Indi Trehan
BACKGROUND: Environmental enteric dysfunction (EED) and linear growth stunting affect many rural agrarian children in the developing world and contribute to the persistently high rates of stunting that are observed worldwide. Effective interventions to consistently ameliorate EED are lacking. OBJECTIVE: We tested whether a bundle of safe and affordable interventions would decrease EED and stunting over 12-24 wk in a cohort of rural Malawian children 12-35 mo old...
January 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27797333/-the-effect-of-sulodexide-on-placental-mitochondria-function-in-rats-with-experimental-preeclampsia
#19
T A Popova, V N Perfilova, G A Zhakupova, V E Verovsky, O V Ostrovskij, I N Tyurenkov
Substitution of drinking water for 1.8% NaCl in pregnant rats caused a pronounced increase in arterial pressure by 24,3% and urinary protein by 117% to day 21 of pregnancy. State 4 respiration of isolated placental mitochondria in the group of negative control was 3- and 1.5-fold higher with malate/glutamate and succinate as substrates than in placental mitochondria isolated from uncomplicated pregnant animals. This led to a decrease of the respiratory control ratio. These results suggest that development of experimental preeclampsia is accompanied by mitochondrial dysfunction through uncoupling of oxidative phosphorylation...
July 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27794188/impaired-contractility-of-the-circular-striated-urethral-sphincter-muscle-may-contribute-to-stress-urinary-incontinence-in-femal-zucker-fatty-rats
#20
Yung-Chin Lee, Guiting Lin, Guifang Wang, Amanda Reed-Maldonado, Zhihua Lu, Lin Wang, Lia Banie, Tom F Lue
AIM: Obesity has been an independent risk factor for female stress urinary incontinence (SUI), the mechanism of this association remains unknown. The aim of this study is to validate the hypothesis that urethral dysfunction is a possible contributor to SUI in obese women. METHODS: Ten Zucker Fatty (ZF) (ZUC-Lepr(fa) 185) and 10 Zucker Lean (ZL) (ZUC-Lepr(fa) 186) female rats at 12-week-old were used in this experiment. The urethral sphincter rings were harvested from the bladder neck through to the most proximal 2/3 regions...
October 29, 2016: Neurourology and Urodynamics
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