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Urinary retention fatigue

R Wells, A Tonkin
Patients with autonomic dysfunction may present with a variety of seemingly unrelated symptoms, both generalised and involving specific systems, including fatigue, difficulty concentrating, orthostatic intolerance, palpitations, constipation or diarrhoea, early satiety, urinary retention or incontinence and erectile dysfunction. Failure to connect the diverse symptoms with a single underlying mechanism may lead to incorrect diagnoses, inappropriate interventions and frustration on the part of both doctors and patients...
October 2016: Internal Medicine Journal
Gregor Habl, Matthias Uhl, Sonja Katayama, Kerstin A Kessel, Gencay Hatiboglu, Boris Hadaschik, Lutz Edler, Diana Tichy, Malte Ellerbrock, Thomas Haberer, Maja B Wolf, Heinz-Peter Schlemmer, Jürgen Debus, Klaus Herfarth
PURPOSE: The purpose of this study was to compare safety and feasibility of proton therapy with that of carbon ion therapy in hypofractionated raster-scanned irradiation of the prostate, in a prospective randomized phase 2 trial. METHODS AND MATERIALS: In this trial, 92 patients with localized prostate cancer were enrolled. Patients were randomized to receive either proton therapy (arm A) or carbon ion therapy (arm B) and treated with a total dose of 66 Gy(relative biological effectiveness [RBE]) administered in 20 fractions (single dose of 3...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
K Milinis, A Tennant, C A Young
OBJECTIVES: HASH(0x3e8ffd8) DESIGN: Cross-sectional survey. SETTING: A convenience sample of people with MS routinely attending an appointment with their local MS service. PARTICIPANTS: 701 patients with clinically definite MS. MAIN OUTCOME MEASURES: Demographic details were obtained and patients completed a battery of measures including spasticity (Multiple Sclerosis Spasticity Scale - 88), fatigue (Neurological Fatigue Index - MS), urinary dysfunction (Qualiveen-SF), pain (Neuropathic Pain Scale), mood disorder (Hospital Anxiety and Depression Scale), disability (World Health Organisation Disability Assessment Schedule) and QOL (Leeds Multiple Sclerosis QOL Scale)...
January 2016: Multiple Sclerosis and related Disorders
Jose F Echaiz, Candice Cass, Jeffrey P Henderson, Hilary M Babcock, Jonas Marschall
BACKGROUND: Correlations between symptom documentation in medical records and patient self-report (SR) vary depending on the condition studied. Patient symptoms are particularly important in urinary tract infection (UTI) diagnosis, and this correlation for UTI symptoms is currently unknown. METHODS: This is a cross-sectional survey study in hospitalized patients with Escherichia coli bacteriuria. Patients were interviewed within 24 hours of diagnosis for the SR of UTI symptoms...
September 1, 2015: American Journal of Infection Control
Hubert Kübler, Birgit Scheel, Ulrike Gnad-Vogt, Kurt Miller, Wolfgang Schultze-Seemann, Frank Vom Dorp, Giorgio Parmiani, Christian Hampel, Steffen Wedel, Lutz Trojan, Dieter Jocham, Tobias Maurer, Gerd Rippin, Mariola Fotin-Mleczek, Florian von der Mülbe, Jochen Probst, Ingmar Hoerr, Karl-Josef Kallen, Thomas Lander, Arnulf Stenzl
BACKGROUND: CV9103 is a prostate-cancer vaccine containing self-adjuvanted mRNA (RNActive®) encoding the antigens PSA, PSCA, PSMA, and STEAP1. This phase I/IIa study evaluated safety and immunogenicity of CV9103 in patients with advanced castration-resistant prostate-cancer. METHODS: 44 Patients received up to 5 intra-dermal vaccinations. Three dose levels of total mRNA were tested in Phase I in cohorts of 3-6 patients to determine a recommended dose. In phase II, 32 additional patients were treated at the recommended dose...
2015: Journal for Immunotherapy of Cancer
David Delman, Xianming Peng, Daniel C Zedek, Valerie Jewells, Nizar Chahin, Silva Markovic-Plese
IMPORTANCE: This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM). REPORT: A 40year-old Caucasian female presented with 6months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate...
January 15, 2015: Journal of Neuroimmunology
Ronald C Chen, Peter Chang, Richard J Vetter, Himansu Lukka, William A Stokes, Martin G Sanda, Deborah Watkins-Bruner, Bryce B Reeve, Howard M Sandler
The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee convened four working groups to recommend core sets of patient-reported outcomes to be routinely incorporated in clinical trials. The Prostate Cancer Working Group included physicians, researchers, and a patient advocate. The group's process included 1) a systematic literature review to determine the prevalence and severity of symptoms, 2) a multistakeholder meeting sponsored by the NCI to review the evidence and build consensus, and 3) a postmeeting expert panel synthesis of findings to finalize recommendations...
July 2014: Journal of the National Cancer Institute
Karim Fizazi, Christophe Massard, Petri Bono, Robert Jones, Vesa Kataja, Nicholas James, Jorge A Garcia, Andrew Protheroe, Teuvo L Tammela, Tony Elliott, Leena Mattila, John Aspegren, Annamari Vuorela, Peter Langmuir, Mika Mustonen
BACKGROUND: ODM-201 is a novel androgen receptor (AR) inhibitor designed to block the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuclear translocation. This trial assessed ODM-201's safety, pharmacokinetics, and activity in men with metastatic castration-resistant prostate cancer. METHODS: The ARADES trial is an open-label phase 1-2 trial undertaken in 23 hospitals across Europe and USA with ongoing long-term follow-up...
August 2014: Lancet Oncology
Nancy Carter, Patricia A Miller, Brittany R Murphy, Victoria J Payne, Denise Bryant-Lukosius
PURPOSE/OBJECTIVES: To examine healthcare providers' (HCPs') perceptions of the supportive care needs of men with advanced prostate cancer (APC). RESEARCH APPROACH: A qualitative, descriptive study. SETTING: Healthcare facilities caring for men with APC in a south-central region of Ontario. PARTICIPANTS: 19 nurses, physicians, and allied health providers who cared for men with APC in outpatient settings. METHODOLOGIC APPROACH: Interviews and focus groups...
July 1, 2014: Oncology Nursing Forum
Linda A Wietecha, Dustin D Ruff, Albert J Allen, Laurence L Greenhill, Jeffrey H Newcorn
OBJECTIVE: Examine how different dosing schedules and recent stimulant therapy effect incidence, time to onset, and duration of common treatment-emergent adverse events (TEAEs) during atomoxetine treatment. METHOD: Post hoc analyses including safety data (open-ended questions) from 22 pediatric and 3 adult atomoxetine trials (1998-2009) in patients with attention-deficit/hyperactivity disorder. Most common TEAEs were determined by incidence rates and frequency of consumer and clinician inquiries...
December 2013: Journal of Clinical Psychiatry
M Hensel, J Frenzel, M Späker, E Keil, N Reinhold
BACKGROUND: In view of the development of innovative and non-traumatic surgical techniques, postoperative pain management should be carried out depending on the invasiveness of the intervention. In the present study two analgesic strategies were compared in patients undergoing minimally invasive hysterectomy: epidural analgesia (EDA) and intravenous patient-controlled analgesia (iv-PCA). MATERIAL AND METHODS: For this prospective case controlled study 60 women with benign uterine diseases undergoing vaginal hysterectomy (VH) or laparoscopically assisted vaginal hysterectomy (LAVH) were enrolled...
October 2013: Der Anaesthesist
Eustachio Nettis, Pantalea Delle Donne, Elisabetta Di Leo, Gian Franco Calogiuri, Antonio Ferrannini, Angelo Vacca
INTRODUCTION: Rupatadine fumarate is a second-generation antihistamine provided with a potent, long-lasting and balanced in vivo dual platelet-activating factor (PAF) and histamine antagonist activity and it uniquely combines both activities at a high level of potency. Rupatadine has a rapid onset of action and a long-lasting effect, so a once-daily dosing is permitted, moreover is well tolerated by young adults and the elders. Rupatadine does not present the side effects of first-generation H1-antihistamines, such as somnolence, fatigue, headache, impaired memory and learning, sedation, increased appetite, dry mouth, dry eyes, visual disturbances, constipation, urinary retention and erectile dysfunction...
September 2013: Expert Opinion on Pharmacotherapy
Cheryl L Petersen, Bradd G Hemker, Richard D Jacobson, Anne B Warwick, Safwan S Jaradeh, Michael E Kelly
Paraneoplastic syndromes may affect the central and peripheral nervous system of adults and children with cancer. Neurological symptoms may resolve with treatment of the underlying neoplasm. We report the case of a child with Wilms tumor who presented with generalized weakness, fatigue, ptosis, hypokinesis, dysarthria, urinary retention, facial diplegia, ophthalmoplegia, and autonomic dysfunction. Routine electrodiagnostic testing, including repetitive nerve stimulation, was normal. Clinical features and stimulation single-fiber electromyogram were consistent with a neuromuscular junction transmission disorder, likely Lambert-Eaton myasthenic syndrome...
May 2013: Journal of Pediatric Hematology/oncology
Minori Matsumoto, Katsumi Shigemura, Fukashi Yamamichi, Yuzo Nakano, Hideaki Miyake, Kazushi Tanaka, Soichi Arakawa, Masato Fujisawa
A 65-year-old man with diabetes mellitus (DM) presented with an indwelling urethral catheter placed for urinary retention by his previous doctor. Thereafter, he had fever, vomiting and general fatigue. His blood examination showed severe inflammatory findings. He was diagnosed with acute prostatitis and immediately admitted to our hospital. Pelvic computerized tomography (CT) showed a prostate abscess. We performed transrectal ultrasonographic-guided puncture of the prostate abscess for drainage and blood culture was tested...
October 2012: Hinyokika Kiyo. Acta Urologica Japonica
K Yanai, B Rogala, K Chugh, E Paraskakis, A N Pampura, R Boev
OBJECTIVE: To conduct a systematic review of evidence supporting the safety profiles of frequently used oral H(1)-antihistamines (AHs) for the treatment of patients with histamine-release related allergic diseases, e.g. allergic rhinitis and urticaria, and to compare them to the safety profiles of other medications, mostly topical corticosteroids and leukotriene antagonists (LTRA). RESEARCH DESIGN AND METHODS: Systematic search of the published literature (PubMed) and of the regulatory authorities databases (EMA and FDA) for oral AHs...
April 2012: Current Medical Research and Opinion
Suki Gill, Jessica Thomas, Chris Fox, Tomas Kron, Aldo Rolfo, Mary Leahy, Sarat Chander, Scott Williams, Keen Hun Tai, Gillian M Duchesne, Farshad Foroudi
BACKGROUND: Image-guided radiotherapy (IGRT) increases the accuracy of treatment delivery through daily target localisation. We report on toxicity symptoms experienced during radiotherapy treatment, with and without IGRT in prostate cancer patients treated radically. METHODS: Between 2006 and 2009, acute toxicity data for ten symptoms were collected prospectively onto standardized assessment forms. Toxicity was scored during radiotherapy, according to the Common Terminology Criteria Adverse Events V3...
2011: Radiation Oncology
Aliza Bitton Ben-Zacharia
Symptoms management in multiple sclerosis is an integral part of its care. Accurate assessment and addressing the different symptoms provides increased quality of life among patients with multiple sclerosis. Multiple sclerosis symptoms may be identified as primary, secondary, or tertiary symptoms. Primary symptoms, such as weakness, sensory loss, and ataxia, are directly related to demyelination and axonal loss. Secondary symptoms, such as urinary tract infections as a result of urinary retention, are a result of the primary symptoms...
March 2011: Mount Sinai Journal of Medicine, New York
Yasuhide Hori, Atsushi Hirabayashi, Isao Kuromatsu
We report a case of a large vesicourethral stone resulting from a long-term indwelling urethral catheter. A 66-year-old man visited our hospital emergency room on October 24, 2006 with a chief complaint of difficult urination. Although a urethral catheter was inserted temporarily based on the diagnosis of the doctor on duty, the patient did not return to our hospital for follow-up examination. On July 10, 2008, he was wheeled into our hospital with symptoms of general fatigue, urinary retention and post-renal failure due to urethral catheter obstruction...
May 2010: Hinyokika Kiyo. Acta Urologica Japonica
Jun Tsugawa, Yoshio Tsuboi, Hirosato Inoue, Kenji Ishizuka, Shigemori Takeshita, Tatsuo Yamada
A-46-year-old woman admitted to our hospital because of numbness of bilateral lower limbs and urinary incontinence. The initial neurological examination showed sensory impairment below S1 level with urinary incontinence, indicating epicornus syndrome. Spinal MR imaging demonstrated unremarkable on conventional and enhanced images with Gd-DTPA. Cerebrospinal fluid examination revealed slightly elevated protein level without pleocytosis. Thereafter, subacute ascending myelopathy including flaccid paraparesis and urinary retention, developed...
March 2010: Brain and Nerve, Shinkei Kenkyū No Shinpo
Patricia S Goode, Mary P Fitzgerald, Holly E Richter, William E Whitehead, Ingrid Nygaard, Patricia A Wren, Halina M Zyczynski, Geoffrey Cundiff, Shawn Menefee, Judith M Senka, Xin Gao, Anne M Weber
BACKGROUND: Older participants are often excluded from clinical trials, precluding a representative sample. STUDY DESIGN: Using qualitative and quantitative methods, we examined recruitment and retention of older women with pelvic organ prolapse in two surgical trials: the randomized Colpopexy And Urinary Reduction Efforts (CARE) study and the Longitudinal Pelvic Symptoms and Patient Satisfaction After Colpocleisis cohort study. Using focus groups, we developed a questionnaire addressing factors facilitating and impeding the recruitment and retention of older study participants and administered it to research staff...
September 2008: Journal of the American College of Surgeons
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