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https://www.readbyqxmd.com/read/28337539/homer1-vesl-1-in-the-rat-esophagus-focus-on-myenteric-plexus-and-neuromuscular-junction
#1
J Zimmermann, W L Neuhuber, M Raab
Homer1, a scaffolding protein of the postsynaptic density (PSD), enriched at excitatory synapses is known to anchor and modulate group I metabotropic glutamate receptors (mGluRs) and different channel- and receptor-proteins. Homer proteins are expressed in neurons of different brain regions, but also in non-neuronal tissues like skeletal muscle. Occurrence and location of Homer1 and mGluR5 in myenteric plexus and neuromuscular junctions (NMJ) of rat esophagus have yet not been characterized. We located Homer1 and mGluR5 immunoreactivity (-iry) in rat esophagus and focused on myenteric neurons, intraganglionic laminar endings (IGLEs) and NMJs, using double- and triple-label immunohistochemistry and confocal laser scanning microscopy...
March 23, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28335122/treatment-of-varicose-veins-by-asval-results-at-10-years
#2
Paul Pittaluga, Sylvain Chastanet
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28332006/prenatal-nicotine-exposure-decreases-the-release-of-dopamine-in-the-medial-frontal-cortex-and-induces-atomoxetine-responsive-neurobehavioral-deficits-in-mice
#3
Tursun Alkam, Takayoshi Mamiya, Nami Kimura, Aya Yoshida, Daisuke Kihara, Yuki Tsunoda, Yuki Aoyama, Masayuki Hiramatsu, Hyoung-Chun Kim, Toshitaka Nabeshima
Increased risk of attention-deficit/hyperactivity disorder (AD/HD) is partly associated with the early developmental exposure to nicotine in tobacco smoke. Emerging reports link tobacco smoke exposure or prenatal nicotine exposure (PNE) with AD/HD-like behaviors in rodent models. We have previously reported that PNE induces cognitive behavioral deficits in offspring and decreases the contents of dopamine (DA) and its turnover in the prefrontal cortex (PFC) of offspring It is well known that the dysfunction of DAergic system in the brain is one of the core factors in the pathophysiology of AD/HD...
March 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28329637/dermatological-screening-of-an-elderly-population-the-rotterdam-study
#4
Martijn G H Sanders, Joris A C Verkouteren, Luba M Pardo
BackgroundThe recent WHO burden of disease project showed that the non-fatal skin disease related burden is high, but also that prevalence rates of many common skin diseases are not well documented. The aim of this study is to give an overview of (untreated) skin diseases in a population based sample of elderly.MethodsIn 2010, a full body skin examination (FBSE) was embedded in the Rotterdam Study, a prospective population based cohort study of an elderly white-skinned population in the Netherlands. The examination was conducted by a dermatology-trained physician and focused on most common skin diseases (e...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322084/fine-structure-and-synaptology-of-the-nitrergic-neurons-in-medial-septum-of-the-rat-brain
#5
Katalin Halasy, Balázs Szőke, Gergely Janzsó
The nitrergic neuron population and certain aspects of their connectivity (peptidergic inputs, co-localization with GABA, synaptic target distribution) were studied in the medial septum of the rat brain. The histochemical localization of NADPH diaphorase and immunohistochemical identification of nNOS at light and electron microscopic level was applied. Double-labeling experiments with galanin and leucine enkephalin, moreover the postembedding GABA immunogold staining was also carried out. NADPH diaphorase- and nNOS-immunopositive neurons could be identified inside the borders of medial septum...
March 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28317330/long-term-risk-of-venous-thromboembolism-recurrence-after-isolated-superficial-vein-thrombosis
#6
Jean-Philippe Galanaud, Marie-Antoinette Sevestre, Gilles Pernod, Susan R Kahn, Céline Genty, Hugo Terrisse, Dominique Brisot, Jean-Luc Gillet, Isabelle Quéré, Jean-Luc Bosson
BACKGROUND: Isolated superficial vein thrombosis (iSVT) (without concomitant deep vein thrombosis (DVT) or pulmonary embolism (PE)) is a frequent event but available data on long-term outcomes are scarce and retrospective. Therefore, we aimed to determine prospectively the risk and type of venous thromboembolic (VTE) recurrence after iSVT and compare it with that of proximal DVT. METHODS: Using data from the prospective, multicentre, observational, OPTIMEV study, we assessed at three years and after anticoagulants were stopped, the incidence and the type of VTE recurrence (iSVT/DVT/PE) of patients with a first objectively confirmed iSVT without cancer (n=285) and compared this to patients with a first proximal DVT without cancer (n=262)...
March 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28316983/endovenous-laser-ablation-of-varicose-veins-preserves-biological-properties-of-vascular-endothelium-and-modulates-proinflammatory-agent-profile-more-favorably-than-classic-vein-stripping
#7
Paweł Uruski, Krzysztof Aniukiewicz, Justyna Mikuła-Pietrasik, Patrycja Sosińska, Andrzej Tykarski, Krzysztof Książek, Zbigniew Krasiński
Here we compared effect of serum from varicose patients undergoing endovenous laser ablation (EVLA) and classic vein stripping (CVS) on biological properties of endothelial cells and on the local and systemic profiles of proinflammatory agents. Results showed that serum from EVLA patients improved proliferation and reduced senescence and oxidative stress in the endothelial cells, as compared with the serum from CVS patients. These effects were related to a suppressed activity of TGF-β1, the level of which in the serum from the EVLA patients was decreased...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28316323/a-rare-cause-of-upper-gastrointestinal-hemorrhage-chronic-thrombosis-of-the-splenic-artery
#8
Sevtap Arslan, Mehmet Ruhi Onur, Erhan Akpınar
Upper gastrointestinal bleeding (UGIB) represents one of the most serious conditions of the gastrointestinal tract with a mortality rate of 10%. The main cause of UGIB is peptic ulcer, accounting for 28%-59% of cases. A rare cause of UGIB is submucosal arterial collaterals, which develop after splenic artery thrombosis. UGIB secondary to gastric submucosal collateral arteries should be considered in patients with endoscopic appearance of varicose veins in the absence of portal hypertension. Computed tomography angiography (CTA) is the only fast and noninvasive definitive imaging technique for such patients...
March 17, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28300675/the-morphofunctional-changes-in-the-wall-of-varicose-veins
#9
Jeļena Birdina, Māra Pilmane, Artūrs Ligers
INTRODUCTION: Varicose vein (VV) disease is a frequently occurring pathology of the lower extremities. Although the pathogenesis of varicosity development is not clearly defined, the final common pathway leading to chronic venous insufficiency is the development of venous hypertension, which is associated with severe changes in the venous wall. The aim of this study was to clarify the histological and immunohistochemical changes in great saphenous veins in chronic venous insufficiency...
March 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28284885/predictors-of-recanalization-for-incompetent-great-saphenous-veins-treated-with-cyanoacrylate-glue
#10
Yiu Che Chan, Yuk Law, Grace C Cheung, Stephen W Cheng
PURPOSE: To determine predictors of recanalization in patients treated with endovenous cyanoacrylate. METHODS: Follow-up by serial clinical and duplex examinations was performed at 1 week, 1 month, 6 months, 12 months, and 24 months of 108 legs in 55 patients (21 men, median age 65 y) with primary varicose veins treated with endovenous cyanoacrylate. Cox regression analysis was used to examine venous characteristics before the procedure: diameter of great saphenous vein (GSV), treatment length of GSV, presence of incompetent perforators, clinical severity of varicose vein, and experience of operator as predictors of recanalization...
March 8, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28277860/conservative-treatment-of-pelvic-congestion-syndrome-indications-and-opportunities
#11
S G Gavrilov, O O Turischeva
This brief review describes conservative treatment methods for pelvic venous congestion. The authors present an analysis of the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs), ergot alkaloid derivatives, hormonal agents, venoprotective agents, and compression therapy in the treatment of varicose disease of the pelvic veins (VDPV), as well as indications for medical therapy. The paucity of studies addressing this topic and the need for large multidisciplinary studies to explore the opportunities for non-surgical treatment of VDPV are highlighted...
March 3, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28267111/blind-sided-by-cosmetic-vein-sclerotherapy-a-case-of-ophthalmic-arterial-occlusion
#12
Meena Arunakirinathan, Robbie J E Walker, Noor Hassan, Sally Ameen, Saad Younis
PURPOSE: Cosmetic vein sclerotherapy is increasingly used to treat varicose veins because of its effectiveness and adherence with British Pharmacopoeia specifications. We present the first documented case of ophthalmic artery occlusion resulting in panocular ischemia secondary to intravascular injection of sodium tetradecyl sulfate sclerosant in a young healthy women seeking treatment for prominent facial veins in her forehead. METHODS: The patient presented with unilateral sudden loss of vision...
March 6, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28265131/medical-treatment-for-postthrombotic-syndrome
#13
REVIEW
Federico Silva Palacios, Suman Wasan Rathbun
Deep vein thrombosis (DVT) is a prevalent disease. About 20 to 30% of patients with DVT will develop postthrombotic syndrome (PTS) within months after the initial diagnosis of DVT. There is no gold standard for diagnosis of PTS, but clinical signs include pitting edema, hyperpigmentation, phlebectatic crown, venous eczema, and varicose veins. Several scoring systems have been developed for diagnostic evaluation. Conservative treatment includes compression therapy, medications, lifestyle modification, and exercise...
March 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28255445/a-failure-of-preoperative-duplex-imaging-to-diagnose-a-lower-extremity-venous-aneurysm-in-a-patient-with-severe-chronic-venous-insufficiency
#14
Roy Wesley Jones, Godfrey Ross Parkerson, Mary Ottinger, Eduardo Rodriguez, Brian Park
OBJECTIVE: We present a case of recurrent bilateral lower extremity venous stasis ulcers in association with a superficial venous aneurysm at the right saphenofemoral junction that was misdiagnosed on preoperative duplex scanning. METHODS: A 53-year-old female presented to our clinic with 6-year history of bilateral lower extremity venous stasis ulcers. Her past medical history was significant for refractory venous stasis ulcers of the bilateral lower extremities present for 6 years and morbid obesity...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28255210/postpartum-varicose-veins-supplementation-with-pycnogenol-or-elastic-compression-a-12-month-follow-up
#15
Gianni Belcaro, Mark Dugall, Roberta Luzzi, Edmondo Ippolito, M Rosaria Cesarone
This open registry aimed to evaluate the clinical evolution of postpartum varicose veins (VVs), in healthy women after the second pregnancy, how these veins regain shape and competence, and possible treatments. The registry included two groups of women: (1) those who used elastic compression stockings, and (2) who used an oral venotonic agent (Pycnogenol, 100 mg/d). A total of 12 evaluation targets were established. Minor symptoms were scored in an analogue scale line. A visual analogue scale line evaluated the overall satisfaction relative to elastic compression or Pycnogenol...
March 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28249260/standing-posture-at-work-does-not-increase-the-risk-of-varicose-vein-in-health-care-providers-in-taiwan
#16
Hsin-Kai Huang, Shih-Feng Weng, Shih-Bin Su, Jhi-Joung Wang, How-Ran Guo, Chien-Chin Hsu, Chien-Cheng Huang, Hung-Jung Lin
OBJECTIVE: This study compared the risk of varicose vein (VV) among physicians, non-physician health care providers (HCPs), and general population. SUBJECTS AND METHODS: The Taiwan National Health Insurance Research Database was used to identify 28,844 physicians, 26,099 non-physician HCPs, and age- and sex-matched identical number of patients from the general population. Using logistic regression analyses, the VV risk between physicians and general population, non-physician HCPs and general population, physicians and non-physician HCPs, and among physician specialists was compared by tracing their medical history between 2007 and 2011...
February 28, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28246076/rac1-pharmacological-inhibition-rescues-human-endothelial-dysfunction
#17
Albino Carrizzo, Carmine Vecchione, Antonio Damato, Flavio di Nonno, Mariateresa Ambrosio, Franco Pompeo, Enrico Cappello, Luca Capocci, Mariangela Peruzzi, Valentina Valenti, Giuseppe Biondi-Zoccai, Antonino G M Marullo, Silvia Palmerio, Roberto Carnevale, Chiara C Spinelli, Annibale A Puca, Speranza Rubattu, Massimo Volpe, Junichi Sadoshima, Giacomo Frati, Sebastiano Sciarretta
BACKGROUND: Endothelial dysfunction contributes significantly to the development of vascular diseases. However, a therapy able to reduce this derangement still needs to be identified. We evaluated the effects of pharmacological inhibition of Rac1, a small GTPase protein promoting oxidative stress, in human endothelial dysfunction. METHODS AND RESULTS: We performed vascular reactivity studies to test the effects of NSC23766, a Rac1 inhibitor, on endothelium-dependent vasorelaxation of saphenous vein segments collected from 85 subjects who had undergone surgery for venous insufficiency and from 11 patients who had undergone peripheral vascular surgery...
February 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28229627/moderate-hypothermia-attenuates-%C3%AE-1-adrenoceptor-mediated-contraction-in-human-varicose-spermatic-vein-the-role-of-nitric-oxide-short-communication
#18
K E Nurullahoglu-Atalik, A Cenker
The effects of moderate hypothermia (28 °C) on the response of human varicose spermatic vein to α1-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration-response curves for phenylephrine (10(-9) to 3 × 10(-4) M) were recorded in rings with and without endothelium at 37 and 28 °C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N(G)-nitro-L-arginine methyl ester (10(-4) M) were also determined...
December 2016: Physiol Int
https://www.readbyqxmd.com/read/28219692/prevention-of-thromboembolic-complications-in-patients-with-superficial-vein-thrombosis-given-rivaroxaban-or-fondaparinux-the-open-label-randomised-non-inferiority-surprise-phase-3b-trial
#19
Jan Beyer-Westendorf, Sebastian M Schellong, Horst Gerlach, Eberhard Rabe, Jeffrey I Weitz, Katja Jersemann, Kurtulus Sahin, Rupert Bauersachs
BACKGROUND: Superficial-vein thrombosis can lead to deep-vein thrombosis and pulmonary embolism. Rivaroxaban, an oral factor Xa inhibitor, might simplify treatment compared with fondaparinux because it does not require daily subcutaneous injection and is cheaper. We compared efficacy outcomes in patients with superficial-vein thrombosis and additional risk factors given either rivaroxaban or fondaparinux to assess whether rivaroxaban is non-inferior to fondaparinux in the prevention of thromboembolic complications...
February 16, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28219004/doppler-ultrasonography-of-the-lower-extremity-arteries-anatomy-and-scanning-guidelines
#20
Ji Young Hwang
Doppler ultrasonography of the lower extremity arteries is a valuable technique, although it is less frequently indicated for peripheral arterial disease than for deep vein thrombosis or varicose veins. Ultrasonography can diagnose stenosis through the direct visualization of plaques and through the analysis of the Doppler waveforms in stenotic and poststenotic arteries. To perform Doppler ultrasonography of the lower extremity arteries, the operator should be familiar with the arterial anatomy of the lower extremities, basic scanning techniques, and the parameters used in color and pulsed-wave Doppler ultrasonography...
April 2017: Ultrasonography
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