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https://www.readbyqxmd.com/read/27932624/allele-rs2010963-c-of-the-vegfa-gene-is-associated-with-the-decreased-risk-of-primary-varicose-veins-in-ethnic-russians
#1
Alexandra S Shadrina, Mariya A Smetanina, Ekaterina A Sokolova, Darya V Shamovskaya, Kseniya S Sevost'ianova, Andrey I Shevela, Evgenii Y Soldatsky, Evgenii I Seliverstov, Marina Y Demekhova, Oleg A Shonov, Evgeny A Ilyukhin, Elena N Voronina, Ilya V Pikalov, Igor A Zolotukhin, Alexander I Kirienko, Maxim L Filipenko
OBJECTIVE: To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. METHODS: Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease...
December 8, 2016: Phlebology
https://www.readbyqxmd.com/read/27932281/nutcracker-syndrome-a-rare-cause-of-left-flank-pain-that-can-also-manifest-as-unexplained-pelvic-pain
#2
Jean-Marie Berthelot, Frédéric Douane, Yves Maugars, Eric Frampas
Nutcracker syndrome (NCS) is symptomatic unilateral renal venous hypertension due to compression of the left renal vein between the superior mesenteric artery and aorta (anterior NCS) or between the aorta and spine (posterior NCS). The left ovarian or spermatic vein empties into the left renal vein and is an additional site of venostasis in about half the cases of NCS. The presenting symptom of NCS in about half the cases is atypical left flank pain suggesting a disorder of the lower ribs or thoracolumbar spinal junction, particularly as the pain worsens with standing and increased lumbar lordosis...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27932203/neural-connection-supporting-endogenous-5-hydroxytryptamine-influence-on-autonomic-activity-in-medial-prefrontal-cortex
#3
Hao-Qiang Zhang, Yong Zhang, Lin Liu, Jin-Lian Li, Ya-Cheng Lu, Ying-Ying Yu, Hui Li, Ting Zhang, Ying-Shing Chan, Fu-Xing Zhang, Yun-Qing Li
5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities...
December 1, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27930505/increased-membrane-localization-of-pannexin1-in-human-corneal-synaptosomes-causes-enhanced-stimulated-atp-release-in-chronic-diabetes-mellitus
#4
Hao Cui, Ying Liu, Limin Qin, Liqiang Wang, Yifei Huang
In the present study, we investigated the potential changes in the corneal nerve terminals in non-insulin-dependent diabetes mellitus of moderate duration. The dissected corneas were subjected to a protocol of ultracentrifugation to obtain synaptosomes of sensory nerve terminals. Within these nerve varicosities, 2 major mechanisms were examined, viz., alterations of the mechanosensitive channel pannexin1 and ATP release on stimulation of these terminals. We hypothesized that altered cellular location and function of the pannexin channel may contribute to altered mechanosensitivity of the cornea, which in turn may affect wound healing and primary visual function of the cornea...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928633/rna-processing-body-p-body-dynamics-in-mesophyll-protoplasts-re-initiating-cell-division
#5
Dilbag S Bhullar, Michael B Sheahan, Ray J Rose
The ability of plants to regenerate lies in the capacity of differentiated cells to reprogram and re-enter the cell cycle. Reprogramming of cells requires changes in chromatin organisation and gene expression. However, there has been less focus on changes at the post transcription level. We have investigated P-bodies, sites of post transcriptional gene regulation, in plant cell reprogramming in cultured mesophyll protoplasts; by using a YFP-VARICOSE (YFP-VCSc) translational fusion. We showed an early increase in P-body number and volume, followed by a decline, then a subsequent continued increase in P-body number and volume as cell division was initiated and cell proliferation continued...
December 7, 2016: Protoplasma
https://www.readbyqxmd.com/read/27923637/hypothalamic-neuronal-origin-of-neuropeptide-y-npy-or-cocaine-and-amphetamine-regulated-transcript-cart-fibers-projecting-to-the-tuberomammillary-nucleus-of-the-rat
#6
Eun Y Lee, Young G Hwang, Hyun S Lee
Based on the importance of tuberomammillary nucleus (TMN) as a target for feeding/arousal-related functions, we aimed in the present study to investigate hypothalamic neuronal origin of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) fibers projecting to the histaminergic nucleus. In the first series of experiments, we examined NPY (or CART) fiber distribution within the boundary of adenosine deaminase (ADA)-immunoreactive (ir) TMN regions; extensive NPY (or CART)-ir axon terminals were observed in E4 (TMMd), E3 (TMMv), and E2 (TMVr) subdivisions...
December 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27921060/klippel-trenaunay-syndrome-of-the-rectosigmoid-colon-presenting-as-severe-anemia
#7
Eula Plana Tetangco, Hafiz Muhammad Sharjeel Arshad, Rogelio Silva
A 23-year-old female with Klippel-Trenaunay syndrome presented with abdominal pain and severe anemia. Colonoscopy revealed diffuse venous congestion extending circumferentially from the midsigmoid to the rectum, with multiple large varicosities. This case emphasizes that Klippel-Trenaunay syndrome may have visceral manifestations beyond the classic presentation, which can be a significant source of morbidity and mortality.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27919934/development-and-validation-of-risk-prediction-model-for-venous-thromboembolism-in-postpartum-women-multinational-cohort-study
#8
Alyshah Abdul Sultan, Joe West, Matthew J Grainge, Richard D Riley, Laila J Tata, Olof Stephansson, Kate M Fleming, Catherine Nelson-Piercy, Jonas F Ludvigsson
OBJECTIVE:  To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). DESIGN:  Cohort study. SETTING:  Records from England based Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and data from Sweden based registry. PARTICIPANTS:  All pregnant women registered with CPRD-HES linked data between 1997 and 2014 and Swedish medical birth registry between 2005 and 2011 with postpartum follow-up...
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27919609/randomised-controlled-trial-potential-benefit-of-a-footplate-neuromuscular-electrical-stimulation-device-in-patients-with-chronic-venous-disease
#9
R Ravikumar, K J Williams, A Babber, T R A Lane, H M Moore, A H Davies
OBJECTIVES: Chronic venous disease (CVD) is common, affecting a quarter of the population. Current conservative methods of treatment aim to prevent progression of disease by reducing ambulatory venous pressure. Neuromuscular electrical stimulation (NMES) refers to the use of electrical impulses to elicit muscle contraction. This pilot randomised controlled trial investigates the effect of a footplate NMES device (REVITIVE) on venous flow parameters, limb oedema, and quality of life outcome measures in patients with CVD...
December 2, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27913269/the-structure-organisation-and-perioperative-management-of-ambulatory-surgery-and-anaesthesia-in-france-methodology-of-the-sfar-opera-study
#10
Pierre Albaladejo, Frédéric Aubrun, Charles-Marc Samama, Laurent Jouffroy, Marc Beaussier, Dan Benhamou, Pauline Romegoux, Kristina Skaare, Jean Luc Bosson, Claude Ecoffey
The organization of health care establishments and perioperative care are essential for ensuring the quality of care and safety of patients undergoing outpatient surgery. In order to correctly inventory these organizations and practices, in 2013-2014, the French Society of Anaesthesia and Intensive Care organized an extensive practical survey in French ambulatory surgery units entitled the "OPERA" study (Organisation PERiopératoire de l'anesthésie en chirurgie Ambulatoire). From among all of the ambulatory surgery centres listed by the Agences Régionales de Santé [Regional Health Agencies, France], 206 public and private centres were randomly selected...
November 29, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27898181/endovenous-ablation-therapy-laser-or-radiofrequency-or-foam-sclerotherapy-versus-conventional-surgical-repair-for-short-saphenous-varicose-veins
#11
REVIEW
Sharath Chandra Vikram Paravastu, Margaret Horne, P Dominic F Dodd
BACKGROUND: Short (or small) saphenous vein (SSV) varices occur as a result of an incompetent sapheno-popliteal junction, where the SSV joins the popliteal vein, resulting in reflux in the SSV; they account for about 15% of varicose veins. Untreated varicose veins may sometimes lead to ulceration of the leg, which is difficult to manage. Traditionally, treatment was restricted to surgery or conservative management. Since the 1990s, however, a number of minimally invasive techniques have been developed; these do not normally require a general anaesthetic, are day-case procedures with a quicker return to normal activities and avoid the risk of wound infection which may occur following surgery...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27885298/klippel-trenaunay-syndrome-a-case-report
#12
R K Sah, S Sharma, S Ghimire, B B Bagale, M Kayastha, R H Chapagain
Klippel-Trenaunaysyndrome(KTS) is a rare congenital condition usually presenting with port wine stains, excessive growth of bones and soft tissue and varicose veins which most commonly occurs in the legs, but it also may affect the arms, face, head, or internal organs. We report a case of term male neonate with clinical findings of Port-wine stain, multiple cystic swellings with ultrasonographic findings suggestive of vascular malformations and limb abnormalities in the form ofsoft tissue hypertrophy of right upper limb, polydactyly of right hand and syndactyly of left hand consistent withKlippel-Trenaunay syndrome...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27878794/varicosities-of-the-lower-extremity-new-approaches-cosmetic-or-therapeutic-needs
#13
Luca Spinedi, Heiko Uthoff, Sasan Partovi, Daniel Staub
Varicose veins of the lower extremity (VVLE) are a frequently encountered vascular disorder in the general population. The general view that VVLE are a non-serious disease with primarily aesthetic impact is a common misconception, as the disease can have a significant negative impact on generic and disease-specific quality of life. Further, VVLE may be associated with potentially threatening clinical conditions, such as chronic venous ulceration, venous thromboembolism and haemorrhage from ruptured varicose veins...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27870929/a-clinical-study-of-cutaneous-changes-in-pregnancy
#14
Vinitha V Panicker, Najeeba Riyaz, P K Balachandran
BACKGROUND/OBJECTIVE: Pregnant women experience a myriad of physiological and metabolic changes that affect different organ systems in the body. Cutaneous and appendageal alterations that manifest during pregnancy are largely modulated by hormonal, immunologic, and metabolic factors. Detailed reports encompassing physiological changes and specific dermatoses of pregnancy and effects of various dermatoses on pregnant women are scanty in literature. This study was conducted to examine in detail both physiological changes and specific dermatoses...
November 18, 2016: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/27860055/comparative-reproductive-biology-and-pollinator-specificity-among-sympatric-gomesa-orchidaceae-oncidiinae
#15
E R Pansarin, I Alves-Dos-Santos, L M Pansarin
The incredible pollination mechanisms displayed by orchid flowers has inspired biologists over the centuries. Based on the intriguing flower structures the relation among orchid species and their pollinators has been frequently regarded as very specialized. Given that visits on flowers pollinated by oil-collecting bees are regularly rare and in Oncidiinae the flowers frequently atract exclusively species that act as effective pollinators, the comparative reproductive biology and pollinator specificity of two sympatric Gomesa (G...
November 11, 2016: Plant Biology
https://www.readbyqxmd.com/read/27856418/spinal-afferent-nerve-endings-in-visceral-organs-recent-advances
#16
Nick J Spencer, Vladimir P Zagorodnyuk, Simon J Brookes, Tim James Hibberd
Spinal afferent neurons play a major role in detection and transduction of painful stimuli from internal (visceral) organs. Recent technical advances have made it possible to visualize the endings of spinal afferent axons in visceral organs. Although it is well known that the sensory nerve cell bodies of spinal afferents reside within dorsal root ganglia (DRG), identifying their endings in internal organs has been especially challenging because of a lack of techniques to distinguish them from endings of other extrinsic and intrinsic neurons (sympathetic, parasympathetic and enteric)...
November 17, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27853341/effect-of-the-wide-spread-use-of-endovenous-laser-ablation-on-the-treatment-of-varicose-veins-in-japan-a-large-scale-single-institute-study
#17
Masatoshi Jibiki, Tetsuro Miyata, Sachiko Futatsugi, Mitsumasa Iso, Yasutaka Sakanushi
Background and aims: In Japan, stripping under general anesthesia, lumbar anesthesia and tumescent local anesthesia has been used in the treatment of primary varicose veins due to saphenous vein insufficiency. However endovenous laser ablation (EVLA) using a 980 nm diode laser has received National Health Insurance (NHI) coverage in 2011, while EVLA using a 1470 nm diode laser with a radial 2-ring fiber has received coverage in 2014. As a result, the use of EVLA has become widespread in Japan. We herein report on the results of varicose veins treatment at our hospital...
October 1, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27837181/results-of-ultrasound-guided-foam-sclerotherapy-of-the-great-saphenous-vein-with-new-parameters-of-the-technique
#18
A Baeshko, N Shestak, S Korytko
AIM: To report the outcome of a series of patients with chronic venous disease due to incompetence of the great saphenous vein (GSV) managed by ultrasound-guided foam sclerotherapy (USGFS). DESIGN: Controlled clinical trial with maximum 5-year follow-up of results of USGFS of the GSV with new parameters of the procedure. MATERIALS AND METHODS: This research analyzes the results of USGFS of the GSV (395 GSV) and its tributaries in 326 patients with varicose veins of the lower extremities over the period from January 2009 to January 2014 with the following parameters of the procedure: 60° limb elevation, calf bandage, and cooled foam injection...
November 11, 2016: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27825178/ruscus-genus-a-rich-source-of-bioactive-steroidal-saponins
#19
Milena Masullo, Cosimo Pizza, Sonia Piacente
The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher's broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp...
November 8, 2016: Planta Medica
https://www.readbyqxmd.com/read/27822503/levels-of-cocaine-and-amphetamine-regulated-transcript-in-vagal-afferents-in-the-mouse-are-unaltered-in-response-to-metabolic-challenges
#20
Xuefeng Yuan, Ying Huang, Sarita Shah, Hua Wu, Laurent Gautron
Cocaine- and amphetamine-regulated transcript (CART) is one of the most abundant neuropeptides in vagal afferents, including those involved in regulating feeding. Recent observations indicate that metabolic challenges dramatically alter the neuropeptidergic profile of CART-producing vagal afferents. Here, using confocal microscopy, we reassessed the distribution and regulation of CART(55-102) immunoreactivity in vagal afferents of the male mouse in response to metabolic challenges, including fasting and high-fat-diet feeding...
September 2016: ENeuro
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