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https://www.readbyqxmd.com/read/29678975/incidence-of-superficial-venous-thrombosis-in-primary-care-and-risk-of-subsequent-venous-thromboembolic-sequelae-a-retrospective-cohort-study-performed-with-routine-healthcare-data-from-the-netherlands
#1
Geert-Jan Geersing, Selma Cazemier, Frans Rutten, David A Fitzmaurice, Arno W Hoes
OBJECTIVES: Recent studies in referred populations of patients with superficial venous thrombosis (SVT) report risks of venous thromboembolic (VTE) sequelae (deep vein thrombosis or pulmonary embolism) as high as 25%. Likely, these estimates are lower in non-referred patients, but large-scale population-based studies are lacking. We aimed to estimate the incidence rate of SVT in primary care and quantify its risk of VTE sequelae. DESIGN: A retrospective cohort study, using International Classification of Primary Care coding (K94...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677415/acute-ischemic-stroke-in-a-young-woman-with-no-known-risk-factors
#2
Noureldin Abdelhamid, Salman Farooq, Amrou Sarraj
INTRODUCTION: We aim to highlight a potentially morbid consequence of foam-sclerotherapy for the treatment of varicose veins. CASE REPORT: We report a case of a 41-year-old woman with no significant medical history who presented to the emergency department with sudden onset of focal neurologic deficits. She had undergone varicose vein treatment with foam sclerotherapy 2 days prior. Magnetic resonance imaging of the brain showed acute cerebellar infarct. Computed tomography angiography was unremarkable...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29671380/removal-of-benign-superficial-masses-using-the-trivex-system-preliminary-clinical-results
#3
Sheng-Jun Duan, Run-Zhu Jiang, Ying-Xin Zhang, Hua-Shui Liu, Nai-Shun Zhang, Shi-Ye Zhang
BACKGROUND AND OBJECTIVE: Transilluminated powered phlebectomy using the TriVex system is a new procedure for minimally invasive varicose vein surgery. We used the TriVex system for the removal of benign superficial subcutaneous soft tissue masses, and we also achieved satisfactory clinical effects. The objective of this study was to explore the feasibility, benefits, and technique-related complications of using the TriVex system for the removal of benign superficial masses as a novel and minimally invasive surgical technique...
April 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29663392/sushi-repeat-containing-protein-x-linked-2-a-novel-phylogenetically-conserved-hypothalamo-pituitary-protein
#4
Mehwish Anwer, Tamuna Bolkvadze, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Tuomas Rauramaa, Ville Leinonen, Erwin A van Vliet, Dick F Swaab, Annakaisa Haapasalo, Stina Leskelä, Nea Bister, Tarja Malm, Synnöve Carlson, Eleonora Aronica, Asla Pitkänen
Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel protein associated with language development, synaptic plasticity, tissue remodeling, and angiogenesis. We investigated the expression and spatial localization of SRPX2 in normal mouse, rat, monkey, and human brain using in situ hybridization and immunohistochemistry. Antibody specificity was determined using in vitro siRNA based silencing of SRPX2. Cell type-specific expression was verified by double-labeling with oxytocin or vasopressin. Western blot was used to detect SRPX2 protein in rat and human plasma and cerebrospinal fluid...
April 16, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29660929/ecchymosis-a-novel-sign-in-patients-with-varicose-veins
#5
Ertan Yetkin, Mehmet Ileri, Johannes Waltenberger
BACKGROUND: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. MATERIALS AND METHODS: Four hundred and ninety four patients who had been diagnosed as having varicose vein or chronic venous insufficiency either by clinical examination or Doppler ultrasonography were included in the study...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660117/polymorphisms-of-genes-involved-in-inflammation-and-blood-vessel-development-influence-the-risk-of-varicose-veins
#6
A Shadrina, Y Tsepilov, M Smetanina, E Voronina, E Seliverstov, E Ilyukhin, A Kirienko, I Zolotukhin, M Filipenko
Heredity plays an important role in the etiology of varicose veins (VVs). However, the genetic basis underlying this condition remains poorly understood. Our aim was to replicate top association signals from genome-wide association studies (GWAS) for VVs of lower extremities using two independent datasets - our sample of ethnic Russian individuals (709 cases and 278 controls) and a large cohort of British residents from UK Biobank (10,861 cases and 397,594 controls). Associations of polymorphisms rs11121615, rs6712038, rs507666, rs966562, rs7111987, rs6062618, and rs6905288 were validated in the UK Biobank individuals at a Bonferroni-corrected significance level...
April 16, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29652086/five-year-follow-up-of-a-randomized-clinical-trial-comparing-open-surgery-foam-sclerotherapy-and-endovenous-laser-ablation-for-great-saphenous-varicose-veins
#7
S Vähäaho, K Halmesmäki, A Albäck, E Saarinen, M Venermo
BACKGROUND: New treatment methods have challenged open surgery as a treatment for great saphenous vein (GSV) insufficiency, the most common being ultrasound-guided foam sclerotherapy (UGFS) and endovenous laser ablation (EVLA). This study evaluated the long-term results of surgery, EVLA and UGFS in the treatment of GSV reflux. METHODS: Patients with symptomatic GSV reflux were randomized to undergo either open surgery, EVLA or UGFS. The main outcome measure was the occlusion rate of the GSV at 5 years after operation...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29650024/vglut1-or-vglut2-mrna-positive-neurons-in-spinal-trigeminal-nucleus-provide-collateral-projections-to-both-the-thalamus-and-the-parabrachial-nucleus-in-rats
#8
Chun-Kui Zhang, Zhi-Hong Li, Yu Qiao, Ting Zhang, Ya-Cheng Lu, Tao Chen, Yu-Lin Dong, Yun-Qing Li, Jin-Lian Li
The trigemino-thalamic (T-T) and trigemino-parabrachial (T-P) pathways are strongly implicated in the sensory-discriminative and affective/emotional aspects of orofacial pain, respectively. These T-T and T-P projection fibers originate from the spinal trigeminal nucleus (Vsp). We previously determined that many vesicular glutamate transporter (VGLUT1 and/or VGLUT2) mRNA-positive neurons were distributed in the Vsp of the adult rat, and most of these neurons sent their axons to the thalamus or cerebellum. However, whether VGLUT1 or VGLUT2 mRNA-positive projection neurons exist that send their axons to both the thalamus and the parabrachial nucleus (PBN) has not been reported...
April 12, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29642798/a-retrospective-study-of-a-new-n-butyl-2-cyanoacrylate-glue-ablation-catheter-incorporated-with-application-guiding-light-for-the-treatment-of-venous-insufficiency-twelve-month-results
#9
Turhan Yavuz, Altay Nihat Acar, Huseyin Aydın, Evren Ekingen
Objective This study aims to present the early results of a retrospective study of the use of novel n-butyl-2-cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins. Methods Patients with lower limb venous insufficiency were treated with n-butyl-2-cyanoacrylate (VenaBlock Venous Closure System) between April 2016 and July 2016. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C4b) and great saphenous vein reflux lasting longer than 0...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29628617/varicose-veins-and-lower-extremity-venous-insufficiency
#10
REVIEW
Eric DePopas, Matthew Brown
Lower extremity venous insufficiency and varicose veins are common conditions, affecting up to 25% of women. Herein, we review the pathophysiology of lower extremity venous insufficiency and varicose veins, the epidemiology of varicose veins, clinical diagnosis, and ultrasonographic diagnosis. We also discuss treatment rationale, algorithms, and techniques, with a focus on endovenous great saphenous vein ablation.
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29628609/management-of-chronic-deep-vein-thrombosis-in-women
#11
REVIEW
Rulon L Hardman
Chronic deep vein thrombosis (DVT) affects hundreds of thousands of women in the United States. Chronic DVT can lead to pain, edema, venous ulcers, and varicosities. While there are limited data regarding the management of chronic DVT, several interventional radiology groups aggressively treat chronic DVT to aid patient symptom resolution. Recanalization of occluded veins and venous stenting re-establishes deep vein flow and decreases venous hypertension.
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29619902/risk-factors-of-overactive-bladder-syndrome-and-its-relation-to-sexual-function-in-menopausal-women
#12
Sevil Hakimi, Elham Aminian, Sakineh Mohammad- Alizadeh Charandabi, Parvin Bastani, Marzieh Mohammadi
BACKGROUND: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. METHODS: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire...
February 2018: Urologia
https://www.readbyqxmd.com/read/29616754/venous-insufficiency-differences-in-the-content-of-trace-elements-a-preliminary-report
#13
Agnieszka Rusak, Ewa Karuga-Kuźniewska, Benita Wiatrak, Maria Szymonowicz, Mateusz Stolarski, Małgorzata Radwan-Oczko, Rafał J Wiglusz, Paweł Pohl, Zbigniew Rybak
BACKGROUND: Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Our results show that insufficient veins have different levels of some trace elements: magnesium, calcium, manganese, and silicon compared to control samples. This study could lead to a better understanding of the molecular causes of venous insufficiency and may help to develop better methods of treatment...
April 4, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29615874/structural-and-molecular-properties-of-insect-type-ii-motor-axon-terminals
#14
Bettina Stocker, Christina Bochow, Christine Damrau, Thomas Mathejczyk, Heike Wolfenberg, Julien Colomb, Claudia Weber, Niraja Ramesh, Carsten Duch, Natalia M Biserova, Stephan Sigrist, Hans-Joachim Pflüger
A comparison between the axon terminals of octopaminergic efferent dorsal or ventral unpaired median neurons in either desert locusts ( Schistocerca gregaria ) or fruit flies ( Drosophila melanogaster ) across skeletal muscles reveals many similarities. In both species the octopaminergic axon forms beaded fibers where the boutons or varicosities form type II terminals in contrast to the neuromuscular junction (NMJ) or type I terminals. These type II terminals are immunopositive for both tyramine and octopamine and, in contrast to the type I terminals, which possess clear synaptic vesicles, only contain dense core vesicles...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29607234/large-vaginal-varicosities-in-the-setting-of-pregnancy-without-known-hepatic-or-vascular-risks-a-case-report-and-review-of-the-literature
#15
Mark Sueyoshi, Steven Clevenger, Elaine Hart
Pregnancy may cause the onset of vaginal or vulvar varicosities that may be a concern for hemorrhage risk during childbirth. A 38-year-old female G4P1112 at 34 weeks and 1 day was referred to an outpatient OB/Gyn clinic for evaluation of a large vaginal mass. The referring provider had concern for malignancy. Lesions of the vulva were biopsied and found to be benign. For two months prior to presentation, she was experiencing discomfort with walking, yellow vaginal discharge, and dysuria. Treatment with fluconazole showed no improvement...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29593847/the-crosstalk-between-autonomic-nervous-system-and-blood-vessels
#16
REVIEW
Yulan Sheng, Li Zhu
The autonomic nervous system (ANS), comprised of two primary branches, sympathetic and parasympathetic nervous system, plays an essential role in the regulation of vascular wall contractility and tension. The sympathetic and parasympathetic nerves work together to balance the functions of autonomic effector organs. The neurotransmitters released from the varicosities in the ANS can regulate the vascular tone. Norepinephrine (NE), adenosine triphosphate (ATP) and Neuropeptide Y (NPY) function as vasoconstrictors, whereas acetylcholine (Ach) and calcitonin gene-related peptide (CGRP) can mediate vasodilation...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29588300/episodes-of-extreme-lower-leg-pain-caused-by-intraosseous-varicose-veins
#17
Elisa S Rezaie, Mario Maas, Chantal M A M van der Horst
We present a case of a 67-year-old man with episodes of extreme pain of the right lower extremity that prevented him from walking and sleeping. The patient had a history of varices in both legs. Physical examination showed a pretibial varix of the right leg inferiorly from a painful spot. X-ray of the right lower leg showed a cortex disruption at this spot. MRIs confirmed the disruption of the cortex of the right tibia and demonstrated an intraosseous vessel. The diagnosis intraosseous varices was made and the vein was surgically resected...
March 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29582749/is-radiofrequency-ablation-of-varicose-veins-a-valuable-option-a-systematic-review-of-the-literature-with-a-cost-analysis
#18
Thomas G Poder, Jean-François Fisette, Suzanne K Bédard, Marc-Antoine Despatis
BACKGROUND: Since the 1990s, new techniques for the treatment of varicose veins have emerged, including radiofrequency ablation (RFA) and laser treatment. We performed a study to compare the safety, efficacy and outcomes of RFA compared to those of open surgery and laser ablation for the treatment of varicose veins. We also carried out a cost analysis of RFA compared to open surgery to assess whether RFA could help free up operating room time by being performed in an outpatient context...
April 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29577902/identification-of-aberrant-circular-rna-expression-and-its-potential-clinical-value-in-primary-great-saphenous-vein-varicosities
#19
Wan Zhang, Li Li, Yi Si, Zhenyu Shi, Ting Zhu, Shunjiu Zhuang, Weiguo Fu
This study aimed to identify aberrant circRNA expression in primary great saphenous vein varicosities (PGSVVs) and investigate its potential clinical significance. High-throughput sequencing was applied to analyze the differential expression of circRNAs in three paired vein samples of PGSVVs and a control group. Computational bioinformatics analyses, including gene ontology (GO) analysis and encyclopedia of genes and genomes (KEGG) pathway analysis, were performed to further enrich microRNA data. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to verify the selected aberrant circRNAs in all vein samples, and a receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic and potential clinical significance...
March 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29574743/-morphological-evidence-for-novel-enteric-neuronal-circuitry-in-guinea-pig-distal-colon
#20
D J Smolilo, M Costa, T J Hibberd, D A Wattchow, N J Spencer
The gastrointestinal (GI) tract is unique compared to all other internal organs; it is the only organ with its own nervous system and its own population of intrinsic sensory neurons, known as intrinsic primary afferent neurons (IPANs). How these IPANs form neuronal circuits with other functional classes of neurons in the enteric nervous system (ENS) is incompletely understood. We used a combination of light microscopy, immunohistochemistry and confocal microscopy to examine the topographical distribution of specific classes of neurons in the myenteric plexus of guinea-pig colon, including putative IPAN's, with other classes of enteric neurons...
March 25, 2018: Journal of Comparative Neurology
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