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https://www.readbyqxmd.com/read/29792883/plasma-n-glycan-signatures-associate-with-features-of-inflammatory-bowel-diseases
#1
Florent Clerc, Mislav Novokmet, Viktoria Dotz, Karli R Reiding, Noortje de Haan, Guinevere S M Kammeijer, Hans Dalebout, Marco R Bladergroen, Frano Vukovic, Erdmann Rapp, Stephan R Targan, Gildardo Barron, Natalia Manetti, Anna Latiano, Dermot P B McGovern, Vito Annese, Gordan Lauc, Manfred Wuhrer
BACKGROUND & AIMS: Biomarkers are needed for early detection of Crohn's disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex post-translational modification of proteins that affects their structure and activity. We compared plasma N-glycosylation profiles between patients with CD or UC and healthy individuals (controls). METHODS: We analyzed the total plasma N-glycomes of 2635 patients with inflammatory bowel diseases and 996 controls by mass spectrometry with a linkage-specific sialic acid derivatization technique...
May 21, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29792017/correlations-of-serum-cystatin-c-and-hs-crp-with-vascular-endothelial-cell-injury-in-patients-with-active-systemic-lupus-erythematosus
#2
Dong Gao, Juan Shao, Waishu Jin, Xiujuan Xia, Yan Qu
BACKGROUND: To investigate the correlations of serum cystatin C and high-sensitivity C-reactive protein (hs-CRP) with vascular endothelial cell injury in patients with active systemic lupus erythematosus (SLE). METHODS: A total of 80 patients with SLE treated in our hospital from January 2016 to September 2017 were selected and randomly divided into stable-stage group (n=40) and active-stage group (n=40) using a random number table. The expressions of cystatin C and hs-CRPin stable and active stages were compared, and the inner diameters of brachial artery and levels of vascular endothelial growth factors in stable and active stages were also compared...
May 22, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29791301/the-significance-of-interleukin-6-in-the-early-detection-of-surgical-site-infections-after-definitive-operation-for-gastrointestinal-fistulae
#3
Dongming Zhang, Jianan Ren, Mohamed-Omar Arafeh, Robert G Sawyer, Qiongyuan Hu, Xiuwen Wu, Gefei Wang, Guosheng Gu, Jiang Hu, Mingzhang Li
BACKGROUND: Surgical site infections (SSIs) are among the most common complications after definitive treatment for intestinal fistulae. Serum inflammatory markers including white blood cell count (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), as well as procalcitonin (PCT) have been used to help diagnosis post-operative complications. OBJECTIVE: The goal of this study was to assess the clinical value of inflammatory markers, specifically IL-6, in predicting SSIs after intestinal fistulae resection...
May 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29791075/erythrocyte-sedimentation-rate-measured-using-microhemagglutination-is-not-elevated-in-monoclonal-gammopathy-compared-with-other-diseases
#4
M Kim, Y-S Ju, E J Lee, E Lee, K Jeon, J Lee, H J Kang, H-S Kim, J-S Lee, H J Kim, Y K Lee
BACKGROUND: The erythrocyte sedimentation rate (ESR) as measured using the Westergren method is extremely elevated in patients with monoclonal gammopathy (MG) owing to the abundance of positively charged paraproteins. However, it has not been determined if the ESR is likewise high in patients with MG when measured using alternate ESR methods. METHODS: The ESR was measured using both the modified Westergren and microhemagglutination method (TEST1) in 36 patients with MG and in 159 individuals with other diseases...
May 23, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29791055/high-birth-weight-was-associated-with-increased-radial-artery-intima-thickness-but-not-with-other-investigated-cardiovascular-risk-factors-in-adulthood
#5
I W Johnsson, T Naessén, F Ahlsson, J Gustafsson
AIM: This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40. METHODS: We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at least 4,500g, and compared them with 27 controls selected by the Swedish National Board of welfare with birth weights within ±1 standard deviations scores and similar ages and gender. The study included body mass index (BMI), blood pressure, lipid profile, haemoglobin A1c (HbA1c), C-reactive protein (CRP) and high frequency ultrasound measurements of intima-media thickness, intima thickness and intima:media ratio of the carotid and radial arteries...
May 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29790794/association-of-morning-blood-pressure-surge-with-carotid-intima-media-thickness-and-cardiac-dysfunction-in-patients-with-cardiac-syndrome-x
#6
Ragab A Mahfouz, Mohammad Goda, Islam Galal, Mohamed S Ghareb
Background & hypothesis: We hypothesized that exaggerated morning blood pressure surge, may contribute in cardiac dysfunction and arterial stiffness in patients with cardiac syndrome X. Thus we investigated the impact of morning blood pressure surge on cardiac function and carotid intima-media thickness in subjects with cardiac syndrome X. METHODS: We studied patients with cardiac syndrome X using ambulatory blood pressure monitoring and investigated the association of morning blood pressure surge with carotid intima thickness, left atrial volume index and left ventricular filling (E/e')...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790215/attenuated-nitric-oxide-bioavailability-in-systemic-sclerosis-evidence-from-the-novel-assessment-of-passive-leg-movement
#7
Heather L Clifton, Daniel R Machin, H Jonathan Groot, Tracy M Frech, Anthony J Donato, Russell S Richardson, D Walter Wray
NEW FINDINGS: What is the central question of this study? Do systemic sclerosis (SSc) patients exhibit impaired nitric oxide (NO)-mediated vascular function of the lower limb, and are these decrements correlated with plasma biomarkers for inflammation and oxidative stress? What is the main finding and its importance? Findings indicate impaired NO-mediated vascular function, linked to the incidence of digital ulcers, and a milieu of inflammation and oxidative stress. However, the absence of significant correlations between individual biomarkers and blood flow responses suggests the vasculopathy observed in SSc may not be solely the result of derangements in the redox balance or inflammatory signaling...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29790109/value-of-three-dimensional-speckle-tracking-echocardiography-to-assess-left-ventricular-function-in-hyperuricemia-patients
#8
Xiaojie Zhang, Qing Lu, Zhuojun Zhang, Yongle Chen, Yanan Wang, Youngshi Wang, Zheng Li, Lindi Jiang
To assess the value of three-dimensional speckle tracking echocardiography (3D STE) in evaluating the left ventricular (LV) function in hyperuricemia patients. We enrolled 15 healthy controls and 40 hyperuricemia patients and collected and analyzed full-volume 3D STE images of the left ventricle in the apical four-chamber heart view. Laboratory tests and 3D STE parameters, including left ventricular ejection fraction, left ventricular end-diastolic volume, left ventricular end-systolic volume, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS), were compared between hyperuricemia patients and healthy controls...
May 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29789900/associations-of-sensitive-cardiac-troponin-i-with-left-ventricular-morphology-function-and-prognosis-in-end-stage-renal-disease-patients-with-preserved-ejection-fraction
#9
Kenichiro Otsuka, Koki Nakanishi, Kenei Shimada, Haruo Nakamura, Hitoshi Inanami, Hiroki Nishioka, Kohei Fujimoto, Noriaki Kasayuki, Minoru Yoshiyama
Sensitive cardiac troponin I (cTnI) predicts all-cause and cardiovascular mortality in various clinical settings. However, its clinical significance in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF) has not been fully elucidated. This study investigated the association of cTnI with LV morphology and function, and its long-term outcome in HD patients with preserved LVEF. This prospective study consists of 96 HD patients with preserved LVEF (69 ± 8 years and 63% male) who underwent two-dimensional echocardiographic examination and biomarker tests including cTnI, brain natriuretic peptide, and high-sensitive C-reactive protein...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29789774/pilot-study-of-dose-response-effects-of-exercise-on-change-in-c-reactive-protein-cortisol-and-health-related-quality-of-life-among-cancer-survivors
#10
Jeanette M Ricci, Victoria Flores, Isabela Kuroyama, Arash Asher, Heather P Tarleton
Fatigue, stress, and depression contribute to poor health-related quality of life (HRQoL) among cancer survivors. This study examined the effects of combined aerobic and resistance training (CART) on HRQoL and biomarkers of stress. Cancer survivors ( n  = 76, 91% female, 39% breast cancer, 32% gynecologic cancer) were enrolled in CART for three 60-min sessions, weekly, for 26 weeks. Participants completed the National Institutes of Health's Patient Reported Outcomes Measurement Information System (NIH PROMIS) fatigue assessment and the SF-36...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29789606/the-prognostic-value-of-systemic-inflammation-in-patients-undergoing-surgery-for-colon-cancer-comparison-of-composite-ratios-and-cumulative-scores
#11
Ross D Dolan, Stephen T McSorley, James H Park, David G Watt, Campbell S Roxburgh, Paul G Horgan, Donald C McMillan
INTRODUCTION: The systemic inflammatory response has been proven to have a prognostic value. There are two methods of assessing the systemic inflammatory response composite ratios (R) and cumulative scores (S). The aim of this study was to compare the prognostic value of ratios and scores in patients undergoing surgery for colon cancer. METHODS: Patients were identified prospectively in a single surgical unit. Preoperative neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, CRP (C) and albumin (A) levels were recorded...
May 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29789582/the-concordance-between-upper-and-lower-respiratory-microbiota-in-children-with-mycoplasma-pneumoniae-pneumonia
#12
Wenkui Dai, Heping Wang, Qian Zhou, Xin Feng, Zhiwei Lu, Dongfang Li, Zhenyu Yang, Yanhong Liu, Yinhu Li, Gan Xie, Kunling Shen, Yonghong Yang, Yuejie Zheng, Shuaicheng Li
In recent years, the morbidity of Mycoplasma pneumoniae pneumonia (MPP) has dramatically increased in China. An increasing number of studies indicate that an imbalance in the respiratory microbiota is associated with respiratory infection. We selected 28 hospitalized patients infected with M. pneumoniae and 32 healthy children. Nasopharyngeal (NP) and oropharyngeal (OP) swabs were collected from healthy children, whereas NP, OP and bronchoalveolar lavage (BAL) specimens were collected from patients. Microbiota analysis was performed on all microbial samples using 16 S ribosomal RNA (16 S rRNA) sequencing...
May 23, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29789355/hdl-functionality-and-cardiovascular-outcome-among-non-dialysis-chronic-kidney-disease-patients
#13
Kathrin Untersteller, Sabine Meissl, Markus Trieb, Insa Emrich, Adam Zawada, Michael Holzer, Eva Knuplez, Danilo Fliser, Gunnar Heine, Gunther Marsche
Cardiovascular disease remains the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD profoundly affects high-density lipoprotein (HDL) composition and functionality, but if abnormal HDL independently contributes to cardiovascular events in CKD patients remains elusive. In the present study, we assessed whether compositional and functional properties of HDL predict cardiovascular outcome among 526 non-dialysis CKD patients who participate in the CARE FOR HOMe study. We measured HDL cholesterol, the content of HDL-associated pro-inflammatory serum amyloid A (SAA) and activities of the HDL enzymes paraoxonase and lipoprotein associated phospholipase A2 (Lp-PLA2)...
May 22, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29788487/the-effects-of-metformin-and-weight-loss-on-biomarkers-associated-with-breast-cancer-outcomes
#14
Ruth E Patterson, Catherine R Marinac, Dorothy D Sears, Jacqueline Kerr, Sheri J Hartman, Lisa Cadmus-Bertram, Adriana Villaseñor, Shirley W Flatt, Suneeta Godbole, Hongying Li, Gail A Laughlin, Jesica Oratowski-Coleman, Barbara A Parker, Loki Natarajan
Background: This study investigated the effects of metformin and weight loss on biomarkers associated with breast cancer prognosis. Methods: Overweight/obese postmenopausal breast cancer survivors (n = 333) were randomly assigned to metformin vs placebo and to a weight loss intervention vs control (ie, usual care). The 2 × 2 factorial design allows a single randomized trial to investigate the effect of two factors and interactions between them. Outcomes were changes in fasting insulin, glucose, C-reactive protein (CRP), estradiol, testosterone, and sex-hormone binding globulin (SHBG)...
May 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29788448/inhibition-of-endothelial-progenitor-cells-may-explain-the-high-cardiovascular-event-rate-in-patients-with-rheumatoid-arthritis
#15
Mohamad Adawi, Nina Pastuck, Golan Saaida, Rizak Sirchan, Abdalla Watad, Arnon Blum
Background: Rheumatoid arthritis (RA) patients may suffer cardiovascular (CV) events much more than the general population, and CV disease is the leading cause of death in patients with RA. Our hypothesis was that impaired function of endothelial progenitor cells may contribute to endothelial dysfunction and the clinical CV events of patients with RA. Methods: 27 RA patients (9 males and 18 females) with an active disease and 13 healthy subjects who served as the control group (9 males and 4 females) were enrolled to this prospective study...
May 16, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29788240/predictors-and-management-of-loss-of-response-to-vedolizumab-in-inflammatory-bowel-disease
#16
Eugenia Shmidt, Gursimran Kochhar, Justin Hartke, Prianka Chilukuri, Joseph Meserve, Khadija Chaudrey, Jenna L Koliani-Pace, Robert Hirten, David Faleck, Morris Barocas, Michelle Luo, Karen Lasch, Brigid S Boland, Siddharth Singh, Niels Vande Casteele, Sashidhar Varma Sagi, Monika Fischer, Shannon Chang, Matthew Bohm, Dana Lukin, Keith Sultan, Arun Swaminath, David Hudesman, Nitin Gupta, Sunanda Kane, Edward V Loftus, William J Sandborn, Corey A Siegel, Bruce E Sands, Jean-Frederic Colombel, Bo Shen, Parambir S Dulai
Background: We quantified loss of response (LOR) to vedolizumab (VDZ) in clinical practice and assessed the effectiveness of VDZ dose intensification for managing LOR. Methods: Retrospective review (May 2014-December 2016) of a prospectively maintained inflammatory bowel disease (IBD) registry. Kaplan-Meier estimates were used to determine rates of LOR to VDZ . Independent predictors of LOR were identified using univariate and multivariable Cox proportional hazard regression...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788156/systemic-inflammation-markers-after-simplification-to-atazanavir-ritonavir-plus-lamivudine-in-virologically-suppressed-hiv-1-infected-patients-atlas-m-substudy
#17
Simone Belmonti, Francesca Lombardi, Eugenia Quiros-Roldan, Alessandra Latini, Antonella Castagna, Alberto Borghetti, Gianmaria Baldin, Arturo Ciccullo, Roberto Cauda, Andrea De Luca, Simona Di Giambenedetto
Background: Biomarkers of systemic inflammation predict non-AIDS events and overall mortality in virologically suppressed HIV-1-infected patients. Objectives: To determine whether switching to a dual antiretroviral maintenance therapy was associated with modification of biomarkers of systemic inflammation as compared with continuation of successful standard triple therapy. Methods: In this substudy of the randomized ATLAS-M trial, we compared in virologically suppressed patients the impact at 1 year of simplification to a dual therapy with atazanavir/ritonavir plus lamivudine versus maintaining atazanavir/ritonavir plus two NRTI triple therapy on markers of systemic inflammation...
April 17, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29788058/modeling-immunization-to-infliximab-in-children-with-crohn-s-disease-using-population-pharmacokinetics-a-pilot-study
#18
Antoine Petitcollin, Oriane Leuret, Camille Tron, Florian Lemaitre, Marie-Clémence Verdier, Gilles Paintaud, Guillaume Bouguen, Stéphanie Willot, Eric Bellissant, David Ternant
Background: Antidrug antibodies (ADAs) dramatically increase infliximab clearance and are responsible for underexposure to the drug, leading to treatment failure. This pilot study aimed at developing a population pharmacokinetic model to detect and describe an early increase in infliximab clearance due to ADA. Methods: Twenty children with Crohn's disease (CD) were followed for 1 year or until treatment failure. Infliximab trough concentration, ADA, C-reactive protein (CRP), and Paediatric Crohn's Disease Activity Index (PCDAI) were recorded at each visit...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787958/altered-tryptophan-catabolite-concentrations-in-major-depressive-disorder-and-associated-changes-in-hippocampal-subfield-volumes
#19
Kelly Doolin, Kelly A Allers, Sina Pleiner, Andre Liesener, Chloe Farrell, Leonardo Tozzi, Erik O'Hanlon, Darren Roddy, Thomas Frodl, Andrew Harkin, Veronica O'Keane
BACKGROUND: Tryptophan depletion is a well-replicated biological finding in Major Depressive Disorder (MDD). The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the pathogenesis of depression. IDO expression is driven by inflammatory cytokines, providing a putative link between inflammation and neuropathology. This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC)...
May 19, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29787929/association-between-the-ratio-of-serum-arachidonic-acid-to-eicosapentaenoic-acid-and-the-presence-of-depressive-symptoms-in-a-general-japanese-population-the-hisayama-study
#20
Mao Shibata, Tomoyuki Ohara, Daigo Yoshida, Jun Hata, Naoko Mukai, Hiroyuki Kawano, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya
BACKGROUND: Epidemiological evidence suggests that fish consumption and intake of n-3 polyunsaturated fatty acids (PUFA)-namely, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)-confer protection against depression. However, few studies have addressed the influence of the balance between n-3 PUFA and n-6 PUFA in the human body on depression. METHODS: A total of 2,529 community-dwelling Japanese residents aged ≥ 40 years were assessed for depressive symptoms (defined as a score of 16 points or more on the Center for Epidemiologic Studies Depression Scale [CES-D]) in 2007...
May 14, 2018: Journal of Affective Disorders
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